keyword
https://read.qxmd.com/read/38523387/concurrent-pyoderma-gangrenosum-and-takayasu-arteritis-in-an-infant-diagnostic-challenges-and-treatment-considerations
#21
Gülcan Özomay Baykal, Betül Sözeri
BACKGROUND: Takayasu arteritis (TA) is an uncommon chronic inflammatory and autoimmune disease primarily affecting large vessels, particularly the aorta and its branches. Skin manifestations have been documented in association with TA. Pyoderma gangrenosum (PG) is a chronic neutrophilic dermatosis characterized by destructive, necrotizing, and painful ulcers, predominantly found on the lower extremities. The coexistence of PG and TA is extremely rare, with most reported cases involving adult patients...
2024: Turkish Journal of Pediatrics
https://read.qxmd.com/read/38522472/topical-oxygen-therapy-and-singlet-oxygen-in-wound-healing-a-scoping-review
#22
REVIEW
Martina Sýkorová, Christine Joy Moffatt, Neil Stentiford, Ewa Anna Burian, Sasagaki Katsuhiro, Yang Wei
The aim of this scoping review was to provide an overview of current research into topical oxygen therapies including the under-researched singlet oxygen for wound healing. A scoping review was undertaken using five databases. After duplicates and ineligible studies were excluded, 49 studies were included for a narrative review. Out of the included 49 studies, 45 (91.8%) were published in the past 10 years (2013-2023) with 32 (65.3%) published in the past 5 years (2018-2023). Eight of the studies were systematic reviews and/or meta-analysis and 18 were RCTs...
April 2024: International Wound Journal
https://read.qxmd.com/read/38522455/investigating-low-rates-of-compliance-to-graduated-compression-therapy-for-chronic-venous-insufficiency-a-systematic-review
#23
JOURNAL ARTICLE
Elise M Stevenson, Andrea Coda, Michael D J Bourke
Chronic venous insufficiency (CVI) is a chronic lower limb progressive disorder with significant burden. Graduated compression therapy is the gold-standard treatment, but its underutilisation, as indicated in recent literature, may be contributing to the growing burden of CVI. The aim of this systematic review is to determine the reasons for poor compliance in patients who are prescribed graduated compression therapy in the management of chronic venous insufficiency. A systematic review of the literature was conducted to identify the reasons for non-compliance in wearing graduated compression therapy in the management of chronic venous insufficiency...
April 2024: International Wound Journal
https://read.qxmd.com/read/38521704/follicular-unit-grafting-in-chronic-ulcers-a-valuable-technique-for-integrated-management
#24
JOURNAL ARTICLE
Anahi Belatti, Florencia Bertarini, Virginia Pombo, Luis Mazzuoccolo, Damian Ferrario
Chronic ulcers significantly affect the quality of life of patients and impose a high cost on the healthcare system. The therapeutic management should be comprehensive, taking into consideration the etiological diagnosis of the wound and the characteristics of the wound bed when deciding on a therapeutic proposal appropriate to the healing phase, correcting factors that delay healing. During the epithelialization phase, repair techniques with grafts are recommended to shorten re-epithelialization time, improve the quality of scar tissue, and achieve adequate pain management...
March 22, 2024: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38520224/impact-of-covid-19-on-patients-undergoing-scheduled-procedures-for-chronic-venous-disease
#25
JOURNAL ARTICLE
Ethan Moore, Max V Wohlauer, James Dorosh, Mahmood Kabeil, Rafael D Malgor, Leigh A O'Banion, Gabriel Lopez-Pena, Riley Gillette, Kathryn Colborn, Robert F Cuff, Leah Lucero, Amna Ali, Issam Koleilat, Paola Batarseh, Sonia Talathi, Aksim Rivera, Misty D Humphries, Kevin Ly, Nikolai Harroun, Brigitte K Smith, Anna M Darelli-Anderson, Asad Choudhry, Eric Hammond, Michael Costanza, Vipul Khetarpaul, Ashley Cosentino, Jacob Watson, Rana Afifi, Nicolas J Mouawad, Tze-Woei Tan, Mel Sharafuddin, Judith P Quevedo, Reggie Nkansah, Palcah Shibale, Sherene Shalhub, Judith C Lin
OBJECTIVE: The COVID-19 pandemic has drastically altered the medical landscape. Various strategies have been employed to preserve hospital beds, personal protective equipment, and other resources to accommodate the surges of COVID-19 positive patients, hospital overcapacities, and staffing shortages. This has had a dramatic effect on vascular surgical practice. The objective of this study is to analyze the impact of the COVID-19 pandemic on surgical delays and adverse outcomes for patients with chronic venous disease scheduled to undergo elective operations...
March 23, 2024: Vascular
https://read.qxmd.com/read/38519847/intrarectal-formalin-treatment-for-haemorrhagic-radiation-induced-proctopathy-efficacy-and-safety
#26
JOURNAL ARTICLE
Darina Kohoutova, Ana Wilson, Caroline Gee, Ramy Elhusseiny, Linda Wanders, David Cunningham
AIM: Pelvic radiotherapy is limited by dose-dependent toxicity to surrounding organs. The aim of this prospective study was to evaluate the efficacy and safety of intrarectal formalin treatment for radiotherapy-induced haemorrhagic proctopathy (RHP) at the Royal Marsden Hospital. METHOD: Adult patients were enrolled. Haemoglobin was evaluated before and after formalin treatment. Antiplatelet and/or anticoagulation treatment and administration of transfusion were recorded...
March 22, 2024: Colorectal Disease
https://read.qxmd.com/read/38518135/fraxin-ameliorates-ulcerative-colitis-by-modulating-oxidative-stress-inflammation-and-tlr4-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#27
JOURNAL ARTICLE
Wenkai Sun, Li Hang, Liping Chen, Yun Qu, Yingchun Zhang, Zhiwei Miao, Xiaoyu Wang
OBJECTIVE: UC is a chronic gastrointestinal disorder of uncertain etiology. However, effective therapeutic drug options for UC are relatively limited. Fraxin represents a principal active constituent within the traditional Chinese medicinal herb known as Cortex Fraxini or Qinpi. Nevertheless, the impact of Fraxin on UC remains uncharted. This study aims to explore the potential of Fraxin, a key component of Cortex Fraxini, in inhibiting DSS-induced intestinal inflammation in mice and to unravel the underlying mechanisms...
March 22, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38517652/efficacy-and-safety-of-tofacitinib-for-chronic-plaque-psoriasis-and-psoriatic-arthritis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#28
JOURNAL ARTICLE
Qianqian Dai, Yanfeng Zhang, Qian Liu, Chijin Zhang
OBJECTIVES: To summarize and analyze the results of published randomized controlled trials of tofacitinib for the treatment of chronic plaque psoriasis and psoriatic arthritis(PsA) and discuss its efficacy and safety. PATIENTS AND METHODS: An exhaustive systematic search encompassing PubMed, Cochrane, Embase, and Web of Science databases was conducted up to July 2023. Studies eligible for inclusion were analyzed, organized using Review Manager version 5.4.1 (Cochrane Collaboration, Oxford, UK) and STATA 15...
March 22, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38517042/investigating-the-association-between-the-tissue-expression-of-mirna-101-jak2-stat3-with-tnf-%C3%AE-il-6-il-1%C3%AE-and-il-10-cytokines-in-the-ulcerative-colitis-patients
#29
JOURNAL ARTICLE
Qazaleh Voshagh, Amir Anoshiravani, Amin Karimpour, Golnaz Goodarzi, Sadra Samavarchi Tehrani, Ozra Tabatabaei-Malazy, Ghodratollah Panahi
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease caused by numerous factors, such as immune system dysfunction and genetic factors. MicroRNAs (miRNAs) play a crucial role in UC pathogenesis, particularly via the JAK-STAT pathway. Our aim was to investigate the association between miRNA-101 and JAK2-STAT3 signaling pathway with inflammatory cytokines in UC patients. METHODS: We enrolled 35 UC patients and 35 healthy individuals as the control group, referred to Shariati Hospital, Tehran, Iran...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38516478/the-role-of-gut-microbiome-in-the-pathogenesis-and-the-treatment-of-inflammatory-bowel-diseases
#30
REVIEW
Andrea Vidal-Gallardo, Juan E Méndez Benítez, Leticia Flores Rios, Luis F Ochoa Meza, Rodrigo A Mata Pérez, Edgar Martínez Romero, Andres M Vargas Beltran, Jose L Beltran Hernandez, Douglas Banegas, Brenda Perez, Marily Martinez Ramirez
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is a chronic condition characterized by inflammation of the gastrointestinal tract. Its exact cause is unknown, but it's thought to result from a dysregulated immune response influenced by various factors, including changes in the intestinal microbiota, diet, lifestyle, and genetics. The gut microbiome, consisting of diverse microorganisms, plays a crucial role in maintaining physiological balance, with its disruption leading to inflammatory responses typical of IBD...
February 2024: Curēus
https://read.qxmd.com/read/38515182/economic-burden-of-diabetic-foot-ulcer-a-case-of-iran
#31
JOURNAL ARTICLE
Reza Hashempour, SeyedHadi MirHashemi, Fariba Mollajafari, Soheila Damiri, Ali ArabAhmadi, Behzad Raei
BACKGROUND: Diabetic foot ulcer (DFU) is known as a serious complication of diabetes mellitus in patients with diabetes, imposing heavy medical costs on healthcare systems due to its chronic nature. patients with severe diabetic foot ulcer are often disabled to work, and some of them may even die, leading to associated productivity losses. Since no previous study has investigated the economic burden of DFU in Iran, this study is to estimate the economic burden of diabetic foot disease in Iran...
March 21, 2024: BMC Health Services Research
https://read.qxmd.com/read/38514965/characterization-of-orofacial-features-in-sclerodermatous-chronic-graft-versus-host-disease
#32
JOURNAL ARTICLE
Amal Bajonaid, Praveen Kumar Guntaka, Matthew Harper, Corey Cutler, Christine Duncan, Alessandro Villa, Hervé Y Sroussi, Sook-Bin Woo, Nathaniel S Treister
BACKGROUND: Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (alloHCT). The sclerodermatous form of cGVHD can be particularly debilitating; however, orofacial sclerodermatous involvement remains poorly described. OBJECTIVE: To characterize orofacial features of sclerodermatous cGVHD in a single center cohort of patients who underwent alloHCT. STUDY DESIGN: Retrospective data were collected from electronic medical records and analyzed descriptively...
March 21, 2024: Oral Diseases
https://read.qxmd.com/read/38514374/impact-of-foot-functionality-in-patients-with-systemic-sclerosis-cross-sectional-study
#33
JOURNAL ARTICLE
Esther Chicharro-Luna, Miguel Ángel Gracia-Vesga, Laura Ramos-Petersen, Gabriel Gijón-Nogueron
BACKGROUND: Progressive systemic sclerosis or systemic scleroderma (SS) is a chronic and rare autoimmune disease that mainly affects the skin and various internal organs. Raynaud's phenomenon and digital ulcers are some of the symptoms that affect the foot, causing a decrease in the quality of life of patients. The objective of this study is to determine the functionality of the feet in patients with SS and determine the impact on their daily lives. METHODS: A sample of 165 patients (154 women, 11 men) diagnosed with SS with a mean age of 46...
March 7, 2024: Journal of Tissue Viability
https://read.qxmd.com/read/38514338/-chinese-expert-consensus-on-multidisciplinary-decision-making-model-for-mobility-limitation-in-older-adults-2024-edition
#34
JOURNAL ARTICLE
(no author information available yet)
Mobility limitation is an age-related geriatric syndrome that is affected by multiple factors such as aging, multimorbidity, nutritional status, chronic pain, psychological and social factors, which increases the risk of adverse events such as pressure ulcers, venous thrombosis, constipation, frailty, disability, falls and death in older adults. Early identification of mobility limitation and individualized comprehensive management are of great significance to maintain the functional status and quality of life of older adults...
March 26, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38512756/helicobacter-pylori-and-gastric-cancer-an-update-in-the-literature
#35
JOURNAL ARTICLE
Doris H Toro, Aliana Bofill-Garcia, Miguel Anzalota-Del Toro
Of the chronic bacterial infections that affect humans, Helicobacter pylori (H. pylori) infection is one of the most common. It inhabits the stomachs of half of the adult human population. In Puerto Rico, a US territory, it has an overall prevalence of 33%, similar to the prevalence reported in the population of the US as a whole. Helicobacter pylori infection is responsible for mucosal inflammation that may lead to chronic gastritis, most peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma...
March 2024: Puerto Rico Health Sciences Journal
https://read.qxmd.com/read/38511527/objective-evidence-that-nerve-decompression-surgery-reduces-neuropathic-dfu-recurrence-risk-to-less-than-5
#36
JOURNAL ARTICLE
Scott Nickerson, Dwayne S Yamasaki
SCOPE AND SIGNIFICANCE Care for the diabetic foot ulcer (DFU) continues to be a frustrating challenge. Standard of care (SOC) methods are plagued by regrettable levels of delayed healing, failures to heal, recurrence risk, and association with amputations and early mortality.1 We hope to bring attention to the clinical reports observing that diabetes is frequently accompanied by nerve trunk enlargement. Local sites of compression can then occur that cause neural dysfunction and pain, but respond to surgical nerve decompression (ND) and recover a degree of normal function...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38511520/association-of-tryptophan-kynurenine-metabolites-with-healing-in-chronic-venous-leg-ulcers
#37
JOURNAL ARTICLE
Junglyun Kim, Joyce Stechmiller, Michael Weaver, Debra Lyon, Timothy J Garrett, Fan Yi, Jungmin Park, Magali Rezende de Carvalho, Debra Lynch Kelly
OBJECTIVE: Chronic wound healing is a complex process that is still not well understood. The tryptophan (TRP)-L-Kynurenine (KYN) pathway has recently been under increased scrutiny in regards to wound healing. The study applied metabolomics to elucidate the TRP-L- KYN pathway associated with wound healing in chronic venous leg ulcers (CVLUs). APPROACH: This study used a longitudinal comparative design of 60 serum samples collected from 30 older adult patients with CVLUs, receiving weekly sharp debridement at a wound clinic...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38510702/causal-relationship-between-pcsk9-inhibitor-and-primary-glomerular-disease-a-drug-target-mendelian-randomization-study
#38
JOURNAL ARTICLE
Hangyu Duan, Yue Shi, Qi Zhang, Xiujie Shi, Yifan Zhang, Jing Liu, Yu Zhang
BACKGROUND: Successive observational studies have highlighted low-density lipoprotein cholesterol (LDL-C) as a standalone risk factor for the progression of chronic kidney disease (CKD) to end-stage renal disease. Lowering LDL-C levels significantly reduces the incidence of atherosclerotic events in patients with progressive CKD. Recent research indicates that proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors not only effectively lower LDL-C levels in CKD patients but also exhibit therapeutic potential for autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and ulcerative colitis...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38507616/effectiveness-of-interventions-to-enhance-healing-of-chronic-foot-ulcers-in-diabetes-a-systematic-review
#39
JOURNAL ARTICLE
Pam Chen, Nalini Campillo Vilorio, Ketan Dhatariya, William Jeffcoate, Ralf Lobmann, Caroline McIntosh, Alberto Piaggesi, John Steinberg, Prash Vas, Vijay Viswanathan, Stephanie Wu, Fran Game
BACKGROUND: It is critical that interventions used to enhance the healing of chronic foot ulcers in diabetes are backed by high-quality evidence and cost-effectiveness. In previous years, the systematic review accompanying guidelines published by the International Working Group of the Diabetic Foot performed 4-yearly updates of previous searches, including trials of prospective, cross-sectional and case-control design. AIMS: Due to a need to re-evaluate older studies against newer standards of reporting and assessment of risk of bias, we performed a whole new search from conception, but limiting studies to randomised control trials only...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38506824/orofacial-anomalies-in-kindler-epidermolysis-bullosa
#40
JOURNAL ARTICLE
Susanne Krämer, Anna Lena Hillebrecht, Yao Wang, Mihail-Alexandru Badea, Jose Ignacio Barrios, Sorina Danescu, Ignacia Fuentes, Demet Kartal, Alfred Klausegger, Enrique Ponce de León, Reinhard Schilke, Ivelina Yordanova, Agnes Bloch-Zupan, Cristina Has
IMPORTANCE: Kindler epidermolysis bullosa is a genetic skin-blistering disease associated with recessive inherited pathogenic variants in FERMT1, which encodes kindlin-1. Severe orofacial manifestations of Kindler epidermolysis bullosa, including early oral squamous cell carcinoma, have been reported. OBJECTIVE: To determine whether hypoplastic pitted amelogenesis imperfecta is a feature of Kindler epidermolysis bullosa. DESIGN, SETTINGS, AND PARTICIPANTS: This longitudinal, 2-center cohort study was performed from 2003 to 2023 at the Epidermolysis Bullosa Centre, University of Freiburg, Germany, and the Special Care Dentistry Clinic, University of Chile in association with DEBRA Chile...
March 20, 2024: JAMA Dermatology
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