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https://www.readbyqxmd.com/read/28823119/determinants-of-health-related-quality-of-life-in-iranian-adults-evidence-from-a-cross-sectional-study
#1
Satar Rezaei, Mohammad Hajizadeh, Ali Kazemi, Masoud Khosravipour, Farid Khosravi, Shahab Rezaeian
Purpose: This study aimed to measure the level and determinants of health-related quality of life (HRQoL) in adults in Kermanshah province, the western region of Iran. Methods: Convenience sampling was employed to derive a sample of 998 adults 18 years and older (646 males and 352 females) in Kermanshah city. A two-part self-administered questionnaire was used for data collection. The first part designed to collect information on socio-demographic characteristics, socioeconomic status and life style factors...
August 15, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28823118/epidemiologic-characteristics-of-scrub-typhus-in-jeju-island-korea
#2
Sung Uk Lee
Purpose: Scrub typhus is the most common febrile disease in Autumn season. Jeju Island is the largest island in South Korea and has a distinctive oceanic climate. This study aimed to identify epidemiological characteristics of scrub typhus in Jeju. Methods: From January 2011 to December 2016, total 446 patients were diagnosed with scrub typhus in Jeju. Patient's personal and environmental factors that may relate to scrub typhus had been investigated and retrospectively analyzed...
August 18, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28823078/sesquiterpenes-from-fruits-of-torilis-japonica-with-inhibitory-activity-on-melanin-synthesis-in-b16-cells
#3
Da Hye Song, Yang Hee Jo, Jong Hoon Ahn, Seon Beom Kim, Cheong-Yong Yun, Youngsoo Kim, Bang Yeon Hwang, Mi Kyeong Lee
Melanin, a dark macromolecular pigment, protects skin from harmful damage. However, abnormal accumulation is responsible for hyperpigmentation disorders. Melanogenesis inhibitors have therefore become important constituents in cosmetic products for depigmentation. Torilis japonica Decandolle (Umbelliferae) is a biennial plant which is distributed in East Asia. Fruits of this plant have been used for the treatment of skin disease and inflammation. In our previous study, torilin, a major sesquiterpene of T. japonica, showed an inhibitory effect on melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells...
August 19, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28823077/comparison-of-physical-function-in-early-rheumatoid-arthritis-patients-treated-with-biologics-for-1%C3%A2-year-who-achieved-clinical-remission-or-low-disease-activity
#4
Yosuke Hattori, Daihei Kida, Atsushi Kaneko
This study aimed to evaluate whether targeting clinical remission is appropriate for suppressing physical dysfunction in patients with early rheumatoid arthritis (RA). Subjects were all 75 early RA patients (within 2 years of onset) who were continuously treated with biologics for 12 months at our hospital. We evaluated the Simplified Disease Activity Index (SDAI) and Disability Index of the Health Assessment Questionnaire (HAQ-DI) at 3, 6, and 12 months from the initiation of biologics therapy. Rates of functional remission (HAQ-DI ≤ 0...
August 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28823054/recent-advances-in-synthetic-lipopeptides-as-anti-microbial-agents-designs-and-synthetic-approaches
#5
REVIEW
Jun-Jie Koh, Shuimu Lin, Roger W Beuerman, Shouping Liu
Infectious diseases impose serious public health burdens and continue to be a global public health crisis. The treatment of infections caused by multidrug-resistant pathogens is challenging because only a few viable therapeutic options are clinically available. The emergence and risk of drug-resistant superbugs and the dearth of new classes of antibiotics have drawn increasing awareness that we may return to the pre-antibiotic era. To date, lipopeptides have been received considerable attention because of the following properties: They exhibit potent antimicrobial activities against a broad spectrum of pathogens, rapid bactericidal activity and have a different antimicrobial action compared with most of the conventional antibiotics used today and very slow development of drug resistance tendency...
August 19, 2017: Amino Acids
https://www.readbyqxmd.com/read/28823025/nanomedicine-associated-with-photodynamic-therapy-for-glioblastoma-treatment
#6
REVIEW
Leonardo B de Paula, Fernando L Primo, Antonio C Tedesco
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most recurrent and malignant astrocytic glioma found in adults. Biologically, GBMs are highly aggressive tumors that often show diffuse infiltration of the brain parenchyma, making complete surgical resection difficult. GBM is not curable with surgery alone because tumor cells typically invade the surrounding brain, rendering complete resection unsafe. Consequently, present-day therapy for malignant glioma remains a great challenge. The location of the invasive tumor cells presents several barriers to therapeutic delivery...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28823012/ratio-of-circulating-estrogen-receptors-beta-and-alpha-er%C3%AE-er%C3%AE-indicates-endoscopic-activity-in-patients-with-crohn-s-disease
#7
Pablo M Linares, Alicia Algaba, Ana Urzainqui, Mercedes Guijarro-Rojas, Rafael González-Tajuelo, Jesús Garrido, María Chaparro, Javier P Gisbert, Fernando Bermejo, Iván Guerra, Víctor Castellano, María-Encarnación Fernández-Contreras
BACKGROUND: Data supporting a role of female hormones and/or their receptors in inflammatory bowel disease (IBD) are increasing, but most of them are derived from animal models. Estrogen receptors alpha (ERα) and beta (ERβ) participate in immune and inflammatory response, among a variety of biological processes. Their effects are antagonistic, and the net action of estrogens may depend on their relative proportions. AIM: To determine the possible association between the balance of circulating ERβ and ERα (ERβ/ERα) and IBD risk and activity...
August 19, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28822983/impulsivity-in-parkinson-s-disease-is-associated-with-altered-subthalamic-but-not-globus-pallidus-internus-activity
#8
Peter Justin Rossi, Jonathan B Shute, Enrico Opri, Rene Molina, Corinna Peden, Oscar Castellanos, Kelly D Foote, Aysegul Gunduz, Michael S Okun
BACKGROUND: A significant subset of patients with Parkinson's disease (PD) suffer from impulse control disorders (ICDs). A hallmark feature of many ICDs is the pursuit of rewarding behaviours despite negative consequences. Recent evidence implicates the subthalamic nucleus (STN) and globus pallidus internus (GPi) in reward and punishment processing, and deep brain stimulation (DBS) of these structures has been associated with changes in ICD symptoms. METHODS: We tested the hypothesis that in patients with PD diagnosed with ICD, neurons in the STN and GPi would be more responsive to reward-related stimuli and less responsive to loss-related stimuli...
August 19, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28822980/principal-component-analysis-of-socioeconomic-factors-and-their-association-with-malaria-and-arbovirus-risk-in-tanzania-a-sensitivity-analysis
#9
Esha Homenauth, Debora Kajeguka, Manisha A Kulkarni
Principal component analysis (PCA) is frequently adopted for creating socioeconomic proxies in order to investigate the independent effects of wealth on disease status. The guidelines and methods for the creation of these proxies are well described and validated. The Demographic and Health Survey, World Health Survey and the Living Standards Measurement Survey are examples of large data sets that use PCA to create wealth indices particularly in low and middle-income countries (LMIC), where quantifying wealth-disease associations is problematic due to the unavailability of reliable income and expenditure data...
August 19, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28822958/therapeutic-molecules-against-type-2-diabetes-what-we-have-and-what-are-we-expecting
#10
REVIEW
Ashwini Kumar, Sudhanshu Kumar Bharti, Awanish Kumar
World Health Organization (WHO) has identified diabetes as one of the fastest growing non-communicable diseases with 422 million patients around the world in 2014. Diabetes, a metabolic disease, is characterized primarily by hyperglycemia which results in various macrovascular and microvascular complications like cardiovascular disease and neuropathies which can significantly deteriorate the quality of life. The body either does not manufactures enough insulin (type 1 diabetes or T1DM) or becomes insensitive to physiologically secreted insulin or both (type 2 diabetes or T2DM)...
April 9, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28822916/wip1-dependent-modulation-of-macrophage-migration-and-phagocytosis
#11
Yiting Tang, Bing Pan, Xin Zhou, Kai Xiong, Qian Gao, Lei Huang, Ying Xia, Ming Shen, Shulin Yang, Honglin Liu, Tao Tan, Jianjie Ma, Xuehong Xu, Yulian Mu, Kui Li
Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. Controlling macrophage conversion into foam cells remains a major challenge for treatment of atherosclerotic diseases. Here, we show that Wip1, a member of the PP2C family of Ser/Thr protein phosphatases, modulates macrophage migration and phagocytosis associated with atherosclerotic plaque formation. Wip1 deficiency increases migratory and phagocytic activities of the macrophage under stress conditions. Enhanced migration of Wip1(-/-) macrophages is mediated by Rac1-GTPase and PI3K/AKT signalling pathways...
August 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28822849/cyclic-3-5-adenosine-monophosphate-camp-signaling-in-the-anterior-pituitary-gland-in-health-and-disease
#12
REVIEW
Laura C Hernández-Ramírez, Giampaolo Trivellin, Constantine A Stratakis
The cyclic 3',5'-adenosine monophosphate (cAMP) was the first among the so-called "second messengers" to be described. It is conserved in most organisms and functions as a signal transducer by mediating the intracellular effects of multiple hormones and neurotransmitters. In this review, we first delineate how different members of the cAMP pathway ensure its correct compartmentalization and activity, mediate the terminal intracellular effects, and allow the crosstalk with other signaling pathways. We then focus on the pituitary gland, where cAMP exerts a crucial function by controlling the responsiveness of the cells to hypothalamic hormones, neurotransmitters and peripheral factors...
August 16, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28822838/scavenging-reactive-oxygen-species-inhibits-status-epilepticus-induced-neuroinflammation
#13
Pallavi B McElroy, Li-Ping Liang, Brian J Day, Manisha Patel
Inflammation has been identified as an important mediator of seizures and epileptogenesis. Understanding the mechanisms underlying seizure-induced neuroinflammation could lead to the development of novel therapies for the epilepsies. Reactive oxygen species (ROS) are recognized as mediators of seizure-induced neuronal damage and are known to increase in models of epilepsies. ROS are also known to contribute to inflammation in several disease states. We hypothesized that ROS are key modulators of neuroinflammation i...
August 16, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28822835/neuroprotective-effects-of-acetyl-l-carnitine-on-lipopolysaccharide-induced-neuroinflammation-in-mice-involvement-of-brain-derived-neurotrophic-factor
#14
Filiz Kazak, Gul Fatma Yarim
Neuroinflammation is the inflammation of nervous tissue that can lead to neurodegeneration. Brain-derived neurotrophic factor (BDNF) is a neurotrophin which affects growth, function and survival of neurons, enhances the stabilization of synapses, regulates synaptic function and branching of dendrites and axons. Brain-derived neurotrophic factor is believed to be involved in the pathophysiology of central nervous system (CNS) diseases associated with neuroinflamation. The aim of this study was to investigate new protective and therapeutic effect of acetyl-L-carnitine (ALCAR) in neuroinflammation...
August 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28822833/complete-knockout-of-estrogen-receptor-alpha-is-not-directly-protective-in-murine-lupus
#15
Jennifer L Scott, Jena R Wirth, Jackie Eudaly, Phil Ruiz, Melissa A Cunningham
Systemic lupus erythematosus (SLE) is a chronic and potentially severe autoimmune disease that disproportionately affects women. Despite a known role for hormonal factors impacting autoimmunity and disease pathogenesis, the specific mechanisms of action remain poorly understood. Our laboratory previously backcrossed "estrogen receptor alpha knockout (ERαKO)" mice onto the NZM2410 lupus prone background to generate NZM/ERαKO mice. This original ERαKO mouse, developed in the mid-1990s and utilized in hundreds of published studies, is not in fact ERα null...
August 16, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28822808/bml-111-equilibrated-ace-angii-at1r-and-ace2-ang-1-7-mas-axis-to-protect-hepatic-fibrosis-in-rats
#16
Quandong Hu, Zhenzhen Hu, Qiongfeng Chen, Yonghong Huang, Zi Mao, Fangyun Xu, Xiaoyan Zhou
BACKGROUND: It was recently reported Lipoxins (LXs) had protective effects on fibrous diseases, and renin-angiotensin-aldosterone system (RAAS) had played vital and bidirectional roles in hepatic fibrosis. In this paper, a hepatic fibrosis model, induced by carbon tetrachloride (CCL4) in rats, was used to observe the relations between RAAS and LXs, as well as to further explore the alternative anti-fibrosis mechanisms of LXs. METHODS: The model was evaluated by morphological observations and biochemical assays...
August 16, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28822792/imaging-assessment-of-fibrodysplasia-ossificans-progressiva-qualitative-quantitative-and-questionable
#17
Mona Al Mukaddam, Chamith S Rajapakse, Robert J Pignolo, Frederick S Kaplan, Stacy E Smith
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare autosomal dominant genetic disorder of heterotopic ossification (HO) characterized by skeletal anomalies and episodic soft tissue swelling (flare-ups) that can transform into heterotopic bone. The progressive development of heterotopic bone and progressive arthropathy leads to significant limitation of mobility. This paper will review various imaging modalities used in evaluating episodic soft tissue swelling (flare-ups), heterotopic bone and skeletal anomalies...
August 16, 2017: Bone
https://www.readbyqxmd.com/read/28822768/functional-dissection-and-transport-mechanism-of-magnesium-in-plants
#18
REVIEW
Zhi Chang Chen, Wen Ting Peng, Jian Li, Hong Liao
Magnesium (Mg) is the second most abundant cation in plants, and, as such, is involved in numerous physiological and biochemical processes, including photosynthesis, enzyme activation, and synthesis of nucleic acids and proteins. Due to its relatively small ionic radius and large hydrated radius, Mg binds weakly to soil and root surfaces, and thereby is easily leached from soil. Mg deficiency not only affects crop productivity and quality, but also contributes to numerous chronic human diseases. Therefore, Mg nutrition in plants is an important issue in nutrition and food security...
August 16, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28822764/effect-of-nitric-oxide-releasing-derivative-of-indomethacin-on-prevotella-intermedia-lipopolysaccharide-induced-production-of-proinflammatory-mediators-in-murine-macrophages
#19
So-Hui Choe, Eun-Young Choi, Jin-Yi Hyeon, In Soon Choi, Sung-Jo Kim
The purpose of this study was to investigate the influences of NCX 2121, a nitric oxide (NO)-releasing derivative of indomethacin, upon the generation of proinflammatory mediators using murine macrophages activated by lipopolysaccharide (LPS) isolated from Prevotella intermedia, which is one of the pathogens implicated in periodontal diseases. Inducible NO synthase (iNOS)-derived NO, IL-1β and IL-6 as well as their relevant mRNA were significantly attenuated by NCX 2121 in RAW264.7 cells activated by P. intermedia LPS...
August 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28822761/down-regulation-of-vascular-ppar-%C3%AE-contributes-to-endothelial-dysfunction-in-high-fat-diet-induced-obese-mice-exposed-to-chronic-intermittent-hypoxia
#20
Yanan Zhang, Chunlian Zhang, Haiou Li, Jingdong Hou
Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is associated with endothelial dysfunction. The prevalence of OSA is linked to an epidemic of obesity. CIH has recently been reported to cause endothelial dysfunction in diet-induced obese animals by exaggerating oxidative stress and inflammation, but the underlying mechanism remains unclear. PPAR-γ, a ligand-inducible transcription factor that exerts anti-oxidant and anti-inflammatory effects, is down-regulated in the peripheral tissues in diet-induce obesity...
August 16, 2017: Biochemical and Biophysical Research Communications
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