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https://www.readbyqxmd.com/read/29031219/long-term-correlation-of-subthalamic-beta-band-activity-with-motor-impairment-in-patients-with-parkinson-s-disease
#1
Wolf-Julian Neumann, Franziska Staub-Bartelt, Andreas Horn, Julia Schanda, Gerd-Helge Schneider, Peter Brown, Andrea A Kühn
OBJECTIVES: To investigate the long term association of subthalamic beta activity with parkinsonian motor signs. METHODS: We recruited 15 patients with Parkinson's disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8months post-operatively using the implantable sensing enabled Activa PC+S (Medtronic). Three patients dropped out leaving 12 patients. Recordings were conducted ON and OFF levodopa at rest...
September 20, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29031207/microrna-25-inhibits-high-glucose-induced-apoptosis-in-renal-tubular-epithelial-cells-via-pten-akt-pathway
#2
Huicong Li, Xiaoguang Zhu, Junwei Zhang, Jun Shi
Diabetic nephropathy (DN) has become the major cause of end-stage renal disease (ESRD). It has been demonstrated that apoptosis of renal tubular epithelial cells induced by hyperglycemia contributes to the pathogenesis of DN. Recent researches have corroborated the critical roles of microRNAs (miRNAs) in the apoptosis of various types of cells including renal tubular epithelial cells. However, the eff ; ;ect of miRNAs on the hyperglycemia-induced apoptosis of renal tubular epithelial cells remains unclear...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031145/small-molecule-mediated-upregulation-of-ccr7-ameliorates-murine-experimental-autoimmune-encephalomyelitis-by-accelerating-t-cell-homing
#3
Xin Li, Tingting Lu, Wenwen Xue, Yixuan Wang, Qiong Luo, Huiming Ge, Renxiang Tan, Yan Shen, Qiang Xu
Impairing the infiltration of immune cells into the CNS is a promising target for suppressing the development of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Here, we found that oral administration of a synthetic small molecular compound Fc24 showed potential preventive effects on the development of EAE, including the reduction in EAE severity and a delay in the onset of the disease. Fc24 facilitated the accumulation of both CD4(+) and CD8(+) T cells within spleen and lymph nodes, while having no effect on MOG-specific T cell responses...
October 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29031144/senegenin-exerts-anti-depression-effect-in-mice-induced-by-chronic-un-predictable-mild-stress-via-inhibition-of-nf-%C3%AE%C2%BAb-regulating-nlrp3-signal-pathway
#4
Hongwei Li, Shiyi Lin, Tingting Qin, Hongyan Li, Zhanqiang Ma, Shiping Ma
Depressive disorder is a kind of affective disturbance disease. Emerging evidence has suggested that inflammation may contribute to the pathologic process of depressive disorder. Senegenin (SEN), a major bioactive constituent in Polygala tenuifolia Willd, has much bioactivity including anti-inflammatory and neuroprotection effects. However, the mechanism of its anti-depressant effect in mice remains unknown. This study aimed to explore the anti-depressant effects of SEN on behavioral changes and inflammatory responses in mice induced by chronic un-predictable mild stress (CUMS)...
October 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29031126/artesunate-induces-apoptosis-via-inhibition-of-stat3-in-thp-1-cells
#5
Mei Tan, Ying Rong, Qiong Su, Yan Chen
OBJECTIVE: Our objective was to explore STAT3 expression in patients with acute myeloid leukaemia (AML), assess the anti-proliferative effects of artesunate (ART) on THP-1 cells in vivo and in vitro, and investigate the underlying mechanisms. METHODS: In this study, we examined 30 patients with acute myeloid leukaemia diagnosed in our hospital from January 2015 to January 2016. The 20 control group patients had non-haematological diseases and were hospitalized for the same period...
October 5, 2017: Leukemia Research
https://www.readbyqxmd.com/read/29031088/probing-the-correlation-of-neuronal-loss-neurofibrillary-tangles-and-cell-death-markers-across-the-alzheimer-s-disease-braak-stages-a-quantitative-study-in-humans
#6
Panos Theofilas, Alexander J Ehrenberg, Austin Nguy, Julia M Thackrey, Sara Dunlop, Maria B Mejia, Ana T Alho, Renata Elaine Paraizo Leite, Roberta Diehl Rodriguez, Claudia K Suemoto, Camila F Nascimento, Marcus Chin, Daniel Medina-Cleghorn, Ana Maria Cuervo, Michelle Arkin, William W Seeley, Bruce L Miller, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Udo Rueb, John Neuhaus, Helmut Heinsen, Lea T Grinberg
Clarifying the mechanisms connecting neurofibrillary tangle (NFT) neurotoxicity to neuronal dysfunction in humans is likely to be pivotal for developing effective treatments for Alzheimer's disease (AD). To model the temporal progression of AD in humans, we used a collection of brains with controls and individuals from each Braak stage to quantitatively investigate the correlation between intraneuronal caspase activation or macroautophagy markers, NFT burden, and neuronal loss, in the dorsal raphe nucleus and locus coeruleus, the earliest vulnerable areas to NFT accumulation...
September 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29031078/structural-design-synthesis-and-pharmacological-evaluation-of-thiazoles-against-trypanosoma-cruzi
#7
Gevanio Bezerra de Oliveira Filho, Marcos Veríssimo de Oliveira Cardoso, José Wanderlan Pontes Espíndola, Dayane Albuquerque Oliveira E Silva, Rafaela Salgado Ferreira, Pollyanne Lacerda Coelho, Pâmela Silva Dos Anjos, Emanuelle de Souza Santos, Cássio Santana Meira, Diogo Rodrigo Magalhaes Moreira, Milena Botelho Pereira Soares, Ana Cristina Lima Leite
Chagas disease is one of the most significant health problems in the American continent. benznidazole (BDZ) and nifurtimox (NFX) are the only drugs approved for treatment and exhibit strong side effects and ineffectiveness in the chronic stage, besides different susceptibility among T. cruzi DTUs (Discrete Typing Units). Therefore, new drugs to treat this disease are necessary. Thiazole compounds have been described as potent trypanocidal agents. Here we report the structural planning, synthesis and anti-T...
September 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031076/synthesis-and-evaluation-of-new-pyridyl-pyrazinyl-thiourea-derivatives-neuroprotection-against-amyloid-%C3%AE-induced-toxicity
#8
Jung-Eun Park, Ahmed Elkamhawy, Ahmed H E Hassan, Ae Nim Pae, Jiyoun Lee, Sora Paik, Beoung-Geon Park, Eun Joo Roh
Herein, we report synthesis and evaluation of new twenty six small molecules against β amyloid (Aβ)-induced opening of mitochondrial permeability transition pore (mPTP) using JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The neuroprotective effect of seventeen compounds against Aβ-induced mPTP opening was superior to that of the standard Cyclosporin A (CsA). Fifteen derivatives eliciting increased green to red fluorescence percentage less than 40.0% were evaluated for their impact on ATP production, cell viability and neuroprotection against Aβ-induced neuronal cell death...
September 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031073/discovery-of-novel-diarylpyrazolylquinoline-derivatives-as-potent-anti-dengue-virus-agents
#9
Jin-Ching Lee, Chin-Kai Tseng, Chun-Kuang Lin, Chih-Hua Tseng
A number of diarylpyrazolylquinoline derivatives were synthesized and evaluated for their anti-dengue virus (DENV) activity. Among them, 6-fluoro-2-(1-(4-fluorophenyl)-3- (4-methoxyphenyl)-1H-pyrazol-5-yl)quinoline (11c), 2-[1,3-bis(4-methoxyphenyl)-1H-pyrazol- 5-yl]-6-fluoroquinoline (12c), and 4-[5-(6-fluoroquinolin-2-yl)-3-(4-methoxyphenyl)-1H-pyrazol- 1-yl]benzenesulfonamide (13c) exhibited approximately 10-folds more active anti-DENV-2 activity (IC50 of 1.36, 1.09 and 0.81 μM, respectively) than that of ribavirin (IC50 = 12...
October 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031072/recent-advances-in-discovery-and-development-of-natural-products-as%C3%A2-source-for-anti-parkinson-s-disease-lead-compounds
#10
REVIEW
Hongjia Zhang, Lan Bai, Jun He, Lei Zhong, Xingmei Duan, Liang Ouyang, Yuxuan Zhu, Ting Wang, Yiwen Zhang, Jianyou Shi
Parkinson's disease (PD) is a common chronic degenerative disease of the central nervous system. Although the cause remains unknown, several pathological processes and central factors such as oxidative stress, mitochondrial injury, inflammatory reactions, abnormal deposition of α-synuclein, and cell apoptosis have been reported. Currently, anti-PD drugs are classified into two major groups: drugs that affect dopaminergic neurons and anti-cholinergic drugs. Unfortunately, the existing conventional strategies against PD are with numerous side effects, and cannot fundamentally improve the degenerative process of dopaminergic neurons...
September 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031070/nature-based-molecules-combined-with-rivastigmine-a-symbiotic-approach-for-the-synthesis-of-new-agents-against-alzheimer-s-disease
#11
Giulia Nesi, Qiuhe Chen, Simona Sestito, Maria Digiacomo, Xiaohong Yang, Shengnan Wang, Rongbiao Pi, Simona Rapposelli
Starting from nature as original source, new potential agents with pleiotropic activities have been synthesized and evaluated as neuroprotective agents. In this work, novel nature-based hybrids, combining antioxidant motifs with rivastigmine, have been designed and synthesized. The biological results revealed that the new compounds inhibit both AChE and BuChE. In particular, lipoic acid hybrids LA1, LA2, LA3 resulted to be the most potent inhibitors of BuChE showing IC50 values ranging from 340 to 378 nM. Analogously, all the compounds were able to inhibit the self β-amyloid1-42 aggregation...
October 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031063/anticancer-properties-of-4-thiazolidinone-derivatives-depend-on-peroxisome-proliferator-activated-receptor-gamma-ppar%C3%AE
#12
Konrad A Szychowski, Marcin L Leja, Danylo V Kaminskyy, Anna P Kryshchyshyn, Urszula E Binduga, Oleh R Pinyazhko, Roman B Lesyk, Jakub Tobiasz, Jan Gmiński
Peroxisome proliferator-activated receptors (PPARs) play an important role in numerous chronic diseases such as diabetes, obesity, atherosclerosis and cancer, and PPAR modulators are among the approved drugs and drug-candidates for their treatment. The aim of this study was to elucidate the involvement of PPARs in the mechanism of cytotoxic and pro-apoptotic action of novel anticancer 4-thiazolidinone derivatives (Les-2194, Les-3377, Les-3640) and approved 4-thiazolidinones (Rosiglitazone, Pioglitazone) towards the human squamous carcinoma (SCC-15) cell line...
September 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031050/paraquat-affects-mitochondrial-bioenergetics-dopamine-system-expression-and-locomotor-activity-in-zebrafish-danio-rerio
#13
Xiao H Wang, Christopher L Souders, Yuan H Zhao, Christopher J Martyniuk
The dipyridyl herbicide paraquat induces oxidative stress in cells and is implicated in adult neurodegenerative diseases. However, less is known about paraquat toxicity in early stages of vertebrate development. To address this gap, zebrafish (Danio rerio) embryos were exposed to 1, 10 and 100 μM paraquat for 96 h. Paraquat did not induce significant mortality nor deformity in embryos and larvae, but it did accelerate time to hatch. To evaluate whether mitochondrial respiration was related to earlier hatch times, oxygen consumption rate was measured in whole embryos...
October 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29031029/glutathione-peroxidase-activity-plasma-total-antioxidant-capacity-and-urinary-f2-isoprostanes-as-markers-of-oxidative-stress-in-anemic-dogs
#14
A Kendall, A Woolcock, A Brooks, G E Moore
BACKGROUND: Oxidative stress plays a role in the pathophysiology of several diseases and has been documented as a contributor to disease in both the human and veterinary literature. One at-risk cell is the erythrocyte, however, the role of oxidative stress in anemia in dogs has not been widely investigated. HYPOTHESIS/OBJECTIVE: Anemic dogs will have an alteration in the activity of glutathione peroxidase (GPx), a decrease in of total antioxidant capacity (TAC), and an increased concentration of urinary 15-F2 -isoprostanes (F2 -IsoP) when compared to healthy dogs...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29029375/treatment-and-disease-management-of-multiple-sclerosis-patients-a-review-for-nurse-practitioners
#15
Cortnee Roman, Kara Menning
BACKGROUND AND PURPOSE: This review discusses the role of the nurse practitioner (NP) in evaluating the clinical effects, potential side effects, and monitoring requirements for treatment options in multiple sclerosis (MS) and provides guidance on how to help patients understand these issues. METHODS: A literature search was conducted on PubMed to identify publications on monitoring and disease management of MS patients. Additional resources included drug information web sites and package inserts...
October 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29029341/an-increased-concentration-of-receptor-activator-of-nuclear-factor-kappa-b-ligand-pre-dates-the-onset-of-rheumatoid-arthritis
#16
Linda Johansson, Lisbeth Ärlestig, Heidi Kokkonen, Mikael Brink, Solbritt Rantapää-Dahlqvist
Objectives: RANK ligand (RANKL) is involved in destruction and osteoporosis in RA. In this study, the relationships between RANKL and ACPA, anti-carbamylated protein antibodies (anti-CarP), cytokines and chemokines were analysed in individuals before the onset of RA symptoms, and their associations with radiological findings at disease onset were assessed. Methods: This was a case-control study performed within the Medical Biobank of Northern Sweden that included 470 pre-symptomatic individuals [334 women and 136 men; mean (s...
September 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029312/prefusion-f-postfusion-f-g-antibodies-and-disease-severity-in-infants-and-young-children-with-acute-respiratory-syncytial-virus-infection
#17
Cristina Capella, Supranee Chaiwatpongsakorn, Erin Gorrell, Zachary A Risch, Fang Ye, Sara E Mertz, Sara M Johnson, Melissa Moore-Clingenpeel, Octavio Ramilo, Asuncion Mejias, Mark E Peeples
Background: Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infection in infants. Maternally-derived RSV-specific antibodies play a role in protection against RSV infection in early life, but data regarding the concentration and specificity of those antibodies are incomplete. Methods: We prospectively enrolled a cohort of previously healthy infants and young children hospitalized (n=45) or evaluated as outpatients (n=20) for RSV infection, and healthy non-infected age-matched controls (n=18)...
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029308/difficult-to-treat-rheumatoid-arthritis-an-area-of-unmet-clinical-need
#18
Maria J H de Hair, Johannes W G Jacobs, Jan L M Schoneveld, Jacob M van Laar
Increased effectiveness of pharmacological treatments in early RA has led many to believe that difficult-to-treat, established RA is a condition of the past. However, there are still plenty of RA patients who continue to have signs and symptoms suggestive of inflammatory disease activity, despite consecutive treatment with multiple conventional synthetic and biological DMARDs. We argue that difficult-to-treat RA constitutes an area of unmet clinical need and propose a definition of this concept. An overview of what is known about the multiple contributory factors varying for each individual patient, and an approach towards improved patient-tailored management are presented...
October 4, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029298/the-effect-of-larval-diet-on-adult-survival-swarming-activity-and-copulation-success-in-male-aedes-aegypti-diptera-culicidae
#19
Bethan J Lang, Stefano Idugboe, Kirelle McManus, Florence Drury, Alima Qureshi, Lauren J Cator
Control of Aedes aegypti (L.) (Diptera: Culicidae) populations is vital for reducing the transmission of several pervasive human diseases. The success of new vector control technologies will be influenced by the fitness of laboratory-reared transgenic males. However, there has been relatively little published data on how rearing practices influence male fitness in Aedes mosquitoes. In the laboratory, the effect of larval food availability on adult male fitness was tested, using a range of different fitness measures...
October 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029294/cardiovascular-events-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-a-meta-analysis-of-observational-studies
#20
Eline Houben, Erik L Penne, Alexandre E Voskuyl, Joost W van der Heijden, René H J Otten, Maarten Boers, Tiny Hoekstra
Objectives: Several chronic inflammatory diseases are associated with cardiovascular disease, but the risk in ANCA-associated vasculitis is poorly quantified. The aim of the present study was to review the evidence for an increased cardiovascular risk, including ischaemic heart disease, cerebrovascular accidents and peripheral arterial disease, in patients with ANCA-associated vasculitis. Methods: A comprehensive systematic review was conducted in accordance with guidelines of preferred reporting items for systematic reviews and meta-analyses...
September 18, 2017: Rheumatology
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