keyword
https://read.qxmd.com/read/37456255/quality-of-life-and-wellbeing-among-breast-cancer-patients-in-lahore-pakistan
#21
JOURNAL ARTICLE
Fiza Ayub, Tahir Mehmood Khan, Mirza Rafi Baig, Muhammad Usman Amin, Humera Tahir
BACKGROUND: Breast cancer has a high incidence rate, emphasizing the necessity of enhanced information on health-related quality of life (HrQOL) in this population of patients. The aim of this study was to identify the factors influencing the QOL experienced by patients in Pakistan. METHODS: A cross-sectional study was conducted on women with breast cancer, and four instruments were used on a random sample of 130 Pakistani women: FACIT-B Version 4 questionnaire,WHO causality assessment scale, Naranjo's algorithm, and a demographic/clinical characteristics section...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37397386/case-report-irinotecan-induced-interstitial-lung-disease-in-an-advanced-colorectal-cancer-patient-resurfacing-decades-after-allogeneic-bone-marrow-transplantation-for-aplastic-anemia-a-case-report-and-narrative-review-of-literature
#22
Keisuke Baba, Yasuo Matsubara, Yoshihiro Hirata, Yasunori Ota, Satoshi Takahashi, Narikazu Boku
Two mechanisms of drug-induced interstitial lung disease (DILD) have been reported: 1) direct injury of lung epithelial cells and/or endothelial cells in lung capillaries by the drug and/or its metabolites and 2) hypersensitivity reactions. In both mechanisms, immune reactions such as cytokine and T cell activation are involved in DILD. While past and present lung diseases and accumulative lung damage due to smoking and radiation are risk factors for DILD, the association between the immune status of the host and DILD is not well known...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37394455/-consideration-of-the-characteristics-of-oral-iron-preparations-from-the-viewpoint-of-the-mechanism-of-nausea-and-vomiting
#23
RANDOMIZED CONTROLLED TRIAL
Takuji Machida, Kenji Iizuka
The nausea and vomiting that occur as a result of oral iron administration for the treatment of iron-deficiency anemia (IDA) can cause significant physical and emotional stress in patients. Because iron is absorbed from the intestine as ferrous iron, the most widely used treatment for IDA is oral ferrous agents. However, ferrous forms are more toxic than ferric forms because ferrous forms readily generate free radicals. A randomized, double-blind, active-controlled, multicenter non-inferiority study conducted in Japan showed that ferric citrate hydrate (FC) was just as effective as sodium ferrous citrate (SF) in the treatment of IDA, with a lower incidence of adverse reactions such as nausea and vomiting compared with SF...
2023: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://read.qxmd.com/read/37305548/the-efficacy-and-safety-of-trilaciclib-in-preventing-chemotherapy-induced-myelosuppression-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#24
Jingyue Qiu, Dandan Sheng, Fei Lin, Peng Jiang, Ning Shi
Background: This study aims to assess the clinical efficacy and safety of Trilaciclib in preventing chemotherapy-induced myelosuppression in adult patients through meta-analysis. Methods: The PubMed, Embase, Cochrane Library, Clinical Trials, EU Clinical Trials Register, and International Clinical Trials Registry Platform were searched up to 25 October 2022. Only randomized controlled trials (RCTs) comparing the clinical outcomes of Trilaciclib and Trilaciclib plus chemotherapy for treating malignant cancers in adult patients were included...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37298616/myricetin-a-significant-emphasis-on-its-anticancer-potential-via-the-modulation-of-inflammation-and-signal-transduction-pathways
#25
REVIEW
Arshad Husain Rahmani, Ahmad Almatroudi, Khaled S Allemailem, Wanian M Alwanian, Basmah F Alharbi, Faris Alrumaihi, Amjad Ali Khan, Saleh A Almatroodi
Cancer is a major public health concern worldwide and main burden of the healthcare system. Regrettably, most of the currently used cancer treatment approaches such as targeted therapy, chemotherapy, radiotherapy and surgery usually cause adverse complications including hair loss, bone density loss, vomiting, anemia and other complications. However, to overcome these limitations, there is an urgent need to search for the alternative anticancer drugs with better efficacy as well as less adverse complications...
June 2, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37288835/analysis-of-neutropenia-as-a-predictive-factor-of-the-efficacy-of-trifluridine-tipiracil-treatment
#26
JOURNAL ARTICLE
Loreto Domínguez Senín, María Yeray Rodriguez Garcés, Victoria Aviñó Tarazona, María Amor Urbano, Maria Dolores Santos-Rubio, Juan Bayo Calero
OBJECTIVES: Trifluridine-tipiracil (TAS-102), an oral cytotoxic agent used in adult patients with refractory metastatic colorectal cancer (mCRC), has been associated with neutropenia (chemotherapy-induced neutropenia) (CIN)). MATERIALS AND METHODS: We evaluated the efficacy and safety of TAS-102 in a group of 45 mCRC patients (median age 66 years) in Huelva province, Spain, in a retrospective, multicenter observational study. RESULTS: We showed that the association between TAS-102 and CIN can be used as a predictor of efficacy...
June 8, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37223288/incidence-of-anemia-and-red-blood-cell-rbc-transfusion-requirement-in-breast-cancer
#27
JOURNAL ARTICLE
Nur Aklina Ramli, Salfarina Iberahim, Ahmad Arif Che Ismail, Hasmah Hussin
BACKGROUND: Cancer-related anaemia is one of the main burdens in oncology, although the available data on its prevalence and treatment options such as blood transfusion are often contradictory. This study aimed to evaluate the prevalence of anaemia and the requirement for packed red blood cell (PRBC) transfusion among women with breast cancer (BC) and to determine the associated factors for chemotherapy-induced anaemia (CIA). METHODS: This cross-sectional retrospective study conducted in Kelantan involved 104 newly diagnosed female BC patients from 2015 to 2016 who underwent chemotherapy...
2023: Caspian Journal of Internal Medicine
https://read.qxmd.com/read/37199745/phase-i-trial-of-intravenous-fenretinide-4-hpr-plus-safingol-in-advanced-malignancies
#28
JOURNAL ARTICLE
Alexis C Boulter, Barry J Maurer, Meredith Pogue, Min H Kang, Hwangeui Cho, Amanda Knight, C Patrick Reynolds, Donald Quick, Sanjay Awasthi, David E Gerber
PURPOSE: Fenretinide (4-HPR) is a synthetic retinoid that induces cytotoxicity through dihydroceramide production. Safingol, a stereochemical-variant dihydroceramide precursor, exhibits synergistic effects when administered with fenretinide in preclinical studies. We conducted a phase 1 dose-escalation clinical trial of this combination. METHODS: Fenretinide was administered as a 600 mg/m2 24-h infusion on Day 1 of a 21-day cycle followed by 900 mg/m2 /day on Days 2 and 3...
August 2023: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/37167214/antibiotic-treatment-inhibits-paclitaxel-chemotherapy-induced-activity-deficits-in-female-mice
#29
JOURNAL ARTICLE
Corena V Grant, Kelley Jordan, Melina M Seng, Leah M Pyter
Chemotherapy, a mainstay in the treatment of cancer, is associated with severe and debilitating side effects. Side effects can be physical (e.g., gastrointestinal distress, anemia, and hair loss) or mental (e.g., fatigue, cognitive dysfunction). Chemotherapy is known to alter the gut microbiota; thus, communication through the gut-brain axis may influence behavioral side effects. Here, we used a clinically-relevant paclitaxel chemotherapy regimen in combination with antibiotics to test the hypothesis that gut microbes contribute to chemotherapy-associated fatigue-like behaviors in female mice...
2023: PloS One
https://read.qxmd.com/read/37142543/beyond-current-treatment-of-fanconi-anemia-what-do-advances-in-cell-and-gene-based-approaches-offer
#30
REVIEW
Elena Martínez-Balsalobre, Jean-Hugues Guervilly, Jenny van Asbeck-van der Wijst, Ana Belén Pérez-Oliva, Christophe Lachaud
Fanconi anemia (FA) is a rare inherited disorder that mainly affects the bone marrow. This condition causes decreased production of all types of blood cells. FA is caused by a defective repair of DNA interstrand crosslinks and to date, mutations in over 20 genes have been linked to the disease. Advances in science and molecular biology have provided new insight between FA gene mutations and the severity of clinical manifestations. Here, we will highlight the current and promising therapeutic options for this rare disease...
April 28, 2023: Blood Reviews
https://read.qxmd.com/read/36970161/a-rare-cause-of-recurrent-haemolytic-anaemia-carboplatin-and-paclitaxel-induced-autoimmune-haemolytic-anaemia
#31
JOURNAL ARTICLE
Pitchaporn Yingchoncharoen, Jerapas Thongpiya, Shrinkhala Maharjan, Mahmoud Abdelnabi, Samuel Kim, Sakditad Saowapa, Judy Lalmuanpuii
UNLABELLED: Drug-induced immune haemolytic anaemia (DIIHA) is a rare but serious complication affecting approximately 1 in 1,000,000 patients, but its incidence might be underestimated due to misdiagnosis. Several factors should be considered to ensure an accurate diagnosis, including previous medical history, comorbidities, drug history, the temporal relationship between drug exposure and symptom onset, haemolytic features, and comorbidities in suspected cases. The authors report a case of DIIHA caused by combination chemotherapy with carboplatin and paclitaxel complicated with haeme pigment-induced acute kidney injury...
2023: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/36915997/disulfiram-enhances-the-antitumor-activity-of-cisplatin-by-inhibiting-the-fanconi-anemia-repair-pathway
#32
JOURNAL ARTICLE
Meng Yuan, Qian Wu, Mingyang Zhang, Minshan Lai, Wenbo Chen, Jianfeng Yang, Li Jiang, Ji Cao
A series of chemotherapeutic drugs that induce DNA damage, such as cisplatin (DDP), are standard clinical treatments for ovarian cancer, testicular cancer, and other diseases that lack effective targeted drug therapy. Drug resistance is one of the main factors limiting their application. Sensitizers can overcome the drug resistance of tumor cells, thereby enhancing the antitumor activity of chemotherapeutic drugs. In this study, we aimed to identify marketable drugs that could be potential chemotherapy sensitizers and explore the underlying mechanisms...
March 15, 2023: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/36877527/vincristine-and-dexamethasone-pulses-in-addition-to-maintenance-therapy-among-pediatric-acute-lymphoblastic-leukemia-gd-all-2008-an-open-label-multicentre-randomized-phase-iii-clinical-trial
#33
RANDOMIZED CONTROLLED TRIAL
Kun-Yin Qiu, Jia-Yi Wang, Li-Bin Huang, Chang-Gang Li, Lu-Hong Xu, Ri-Yang Liu, Hui-Qin Chen, Yong-Sheng Ruan, Zi-Jun Zhen, Chi-Kong Li, Jian-Pei Fang
The efficacy and safety on the addition of vincristine (VCR) and dexamethasone (DEX) pulses to maintenance therapy among childhood acute lymphoblastic leukemia (ALL) remain uncertain. Herein, we perform an open-label, multicentre, randomized, phase III clinical trial that was conducted at nine major medical centers in Guangdong Province, China. Patients were randomly assigned either the conventional maintenance therapy (control group, n = 384) or the VCR/DEX pulse (treatment group, n = 375)...
June 2023: American Journal of Hematology
https://read.qxmd.com/read/36829507/anticancer-drugs-paclitaxel-carboplatin-doxorubicin-and-cyclophosphamide-alter-the-biophysical-characteristics-of-red-blood-cells-in-vitro
#34
JOURNAL ARTICLE
Elisaveta Skverchinskaya, Nadezhda Levdarovich, Alexander Ivanov, Igor Mindukshev, Anton Bukatin
Red blood cells (RBCs) are the most numerous cells in the body and perform gas exchange between all tissues. During the infusion of cancer chemotherapeutic (CT) agents, blood cells are the first ones to encounter aggressive cytostatics. Erythrocyte dysfunction caused by direct cytotoxic damage might be a part of the problem of chemotherapy-induced anemia-one of the most frequent side effects. The aim of the current study is to evaluate the functional status of RBCs exposed to mono and combinations of widely used commercial pharmaceutical CT drugs with different action mechanisms: paclitaxel, carboplatin, cyclophosphamide, and doxorubicin, in vitro...
January 31, 2023: Biology
https://read.qxmd.com/read/36822848/-chemotherapy-induced-anemia
#35
JOURNAL ARTICLE
L Shen, S Lu
No abstract text is available yet for this article.
March 1, 2023: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://read.qxmd.com/read/36772901/regorafenib-induced-radiation-recall-presenting-as-acute-blood-loss-anemia-with-rectal-bleeding-and-severe-proctitis
#36
JOURNAL ARTICLE
Madhulika Urella, Mina Shenouda, Toni Pacioles
Radiation recall is a rare inflammatory reaction that occurs in an area that was subjected to prior irradiation that is usually triggered by certain drugs or chemotherapy agents. This reaction is drug-specific for each individual and occurs in about 6% to 9% of the patients receiving chemotherapy after radiation therapy. We report a case of radiation recall-induced severe proctitis which is thought to be triggered by administration of regorafenib for stage IV rectal adenocarcinoma with lung metastases. We present a 65-year-old female patient who was initially diagnosed with stage III T4N1M0 rectal adenocarcinoma that was treated with neoadjuvant concurrent chemoradiotherapy, followed by low anterior resection...
2023: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/36759013/neoadjuvant-sintilimab-and-chemotherapy-in-patients-with-potentially-resectable-esophageal-squamous-cell-carcinoma-keep-g-03-an-open-label-single-arm-phase-2-trial
#37
JOURNAL ARTICLE
Xiaofeng Chen, Xiang Xu, Danping Wang, Jinyuan Liu, Jing Sun, Mingjie Lu, Rui Wang, Bingqing Hui, Xiaofei Li, Chenchen Zhou, Min Wang, Tianzhu Qiu, Shiyun Cui, Nana Sun, Yang Li, Fufeng Wang, Cuicui Liu, Yang Shao, Jinhua Luo, Yanhong Gu
BACKGROUND: The standard neoadjuvant treatments in patients with esophageal squamous cell carcinoma (ESCC) still have either poor safety or efficacy. Better therapies are needed in China. METHODS: This was an open-label, single-arm, phase 2 trial. Patients with potentially resectable ESCC (cT1b-3, Nany, M0 or T4a, N0-1, or M0) received preoperative intravenous sintilimab plus triplet chemotherapy (liposomal paclitaxel, cisplatin, and S-1) every 3 weeks for two cycles...
February 2023: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/36733111/-a-case-of-rectal-cancer-with-hemorrhagic-shock-with-bleeding-controlled-via-stent-placement-that-underwent-radical-resection-after-preoperative-crt
#38
JOURNAL ARTICLE
Katsunori Ami, Yuto Suyama, Akihito Nakanishi, Tomoki Hakozaki, Toshiko Harada, Satoko Monma, Noriyasu Tamura, Kei Ooide, Rikuo Machinami, Naoaki Umetani
Colorectal stents are used mainly for the palliative treatment of colorectal obstruction or preoperative re-obstruction. However, the hemostatic effect of covered stents reportedly induced bleeding of esophageal cancer and varicosities. Here, we report a case of mildly obstructed rectal cancer with severe anemia and hemorrhagic shock that resulted in pulsatile tumor bleeding. Curative surgical resection was performed successfully after the administration of chemoradiotherapy. The patient was a 67-year-old man...
December 2022: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/36733057/-a-case-of-effective-plasma-exchange-for-thrombotic-microangiopathy-during-chemotherapy-for-pancreatic-cancer
#39
JOURNAL ARTICLE
Masafumi Yamashita, Junzo Shimizu, Yasushi Sato, Kazuki Odagiri, Yoshitomo Yanagimoto, Hiroshi Takeyama, Yozo Suzuki, Masakazu Ikenaga, Tomono Kawase, Hiroshi Imamura, Kenzo Akagi, Suguru Iwasawa, Naohiro Tomita, Keizo Dono
The patient was a 78-year-old man. After 4 courses of GEM plus nab-PTX therapy for multiple recurrent liver metastases after pancreatic body cancer surgery, the patient was aware of general malaise and edema of the extremities. Blood tests showed pancytopenia, and he was admitted to the hospital with a diagnosis of chemotherapy-induced pancytopenia. On the second day, hemolytic anemia with crushed red blood cells was observed, suggesting thrombotic microangiopathy (TMA). Considering the possibility of thrombotic thrombocytopenic purpura(TTP), the patient was started on plasma exchange with steroids...
December 2022: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/36715830/a-proactive-approach-to-prevent-hematopoietic-exhaustion-during-cancer-chemotherapy-in-older-patients-temporary-cell-cycle-arrest
#40
REVIEW
Lodovico Balducci, Claire Falandry, Alan List
Age is associated with the decline of multiple organ systems. In older patients, hematological toxicities associated with chemotherapy are often dose limiting, impairing dose intensity and treatment efficacy. Contrary to the classical path using growth factors to activate tissue regeneration, a novel strategy is emerging to prevent chemotherapy toxicity that involves temporary cell-cycle arrest of normal cells, such as hematopoietic or epithelial precursors. This proactive approach may allow the sparing of the stem cell reserve of these tissues...
January 30, 2023: Drugs & Aging
keyword
keyword
51678
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.