keyword
MENU ▼
Read by QxMD icon Read
search

HCAI

keyword
https://www.readbyqxmd.com/read/29675887/synthesis-and-biological-evaluation-of-4-sulfamoylphenyl-sulfocoumarin-carboxamides-as-selective-inhibitors-of-carbonic-anhydrase-isoforms-hca-ii-ix-and-xii
#1
Srinivas Angapelly, Andrea Angeli, Arbaj Jabbar Khan, Posa Venkata SriRamya, Claudiu Trandafir Supuran, Mohammed Arifuddin
With the aim to develop potent and selective human carbonic anhydrase inhibitors (hCAIs), we synthesized 4-sulfamoylphenyl/sulfocoumarin benzamides (5a-r and 7a-q) and evaluated for their inhibition profiles against five isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), the cytosolic CA I and II as well as transmembrane isozymes CA IV, IX and XII. Compounds 5a-r selectively inhibited the isoform hCA II in nanomolar range, being less effective against the other isoforms. As noticeable from the literature, sulfocoumarin (1,2-benzoxathiine 2,2-dioxide) act as "prodrug" inhibitor and get hydrolysed by the esterase CA activity to form 2-hydroxyphenyl-vinylsulfonic acid, which thereafter bind to the enzyme in a similar fashion like coumarins and sulfoxocoumarins...
April 19, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29652978/-importance-of-cleaning-and-disinfection-of-critical-surfaces-in-dental-health-services-impact-of-an-intervention-program
#2
Elena Véliz, Teresa Vergara, Mercedes Pearcy, Jeannette Dabanch
Introduction Dental care has become a challenge for healthcare associated infection prevention programs, since the environment, within other factors, plays an important role in the transmission chain. Materials and Methods An intervention program was designed for the Dental Unit of Hospital Militar de Santiago, between years 2014 and 2015. The program contemplated 3 stages: diagnostic, intervention and evaluation stage. Objective To improve the safety of critical surfaces involved in dental healthcare. Results During the diagnostic stage, the cleaning and disinfection process was found to be deficient...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29628959/a-survey-of-nurses-compliance-with-hand-hygiene-guidelines-in-caring-for-patients-with-cancer-in-a-selected-center-of-isfahan-iran-in-2016
#3
Mostafa Mostafazadeh-Bora, Masoud Bahrami, Abbas Hosseini
Background: Hand hygiene is one of the key ways of preventing healthcare-associated infections (HCAI), especially in patients with cancer. The aim of this study was to determine nurses' compliance with hand hygiene guidelines in caring for patients with cancer in a selected center in Isfahan, Iran, in 2016. Materials and Methods: The present observational study was conducted on nurses in a cancer center in Isfahan in 2016. The participants were selected via convenience sampling method...
March 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29549049/the-first-multi-centre-point-prevalence-survey-in-four-japanese-university-hospitals
#4
H Morioka, M Nagao, S Yoshihara, H Ohge, K Kasahara, N Shigemoto, T Kajihara, M Mori, M Iguchi, Y Tomita, S Ichiyama, T Yagi
BACKGROUND: The Japanese government adopted a national action plan on antimicrobial resistance, which aims to reduce drug-resistant pathogens and antimicrobial use. A point-prevalence survey (PPS) is a useful surveillance method to gain information about hospital epidemiology; however, no multi-centre PPS has previously been performed in Japan. AIM: To investigate general information about hospital epidemiology, healthcare-associated infections (HCAIs), and antimicrobial use in multiple Japanese university hospitals...
March 13, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29432997/a-comparative-study-of-hand-hygiene-and-alcohol-based-hand-rub-use-among-irish-nursing-and-medical-students
#5
Liz M Kingston, Nuala H O'Connell, Colum P Dunne
BACKGROUND: In Ireland, the setting for this study, the national prevalence rate of health care-associated infection (HCAI) in acute-care facilities is 5.2%. Hand hygiene and in particular hand rubbing using alcohol-based hand rub (ABHR) is highly efficacious in preventing HCAI transmission. Yet, compliance among healthcare professionals is sub-optimal. Less is known about the practices of nursing and medical students and no study comparing practices among these groups in Ireland was found...
April 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29408389/hospital-ownership-a-risk-factor-for-nosocomial-infection-rates
#6
C Schröder, M Behnke, C Geffers, P Gastmeier
BACKGROUND: In some countries, a relationship between hospital ownership and the occurrence of healthcare-associated infection (HCAI) rates has been described. AIM: To investigate the association between hospital ownership and occurrence of HCAI in Germany. METHODS: Five different components of the German national nosocomial infection surveillance system were analysed with regard to the influence of hospital ownership in the period 2014-2016...
March 26, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29344098/-time-to-clean-a-systematic-review-and-observational-study-on-the-time-required-to-clean-items-of-reusable-communal-patient-care-equipment
#7
David Scott, Hayley Kane, Annette Rankin
Background: Concerns have been raised over poor standards of hospital cleanliness and insufficient time for staff to clean reusable communal patient care equipment. These items may then act as vectors for the transmission of nosocomial pathogens between hospital patients. Aim: To evaluate the impact of cleaning duration on nosocomial infection rates and estimate the time required to clean care equipment in accordance with national specifications (i.e. a 'time to clean')...
November 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/29317904/a-change-management-approach-to-improving-safety-and-preventing-needle-stick-injuries
#8
Ann-Marie Aziz
Key drivers for preventing healthcare-associated infection (HCAI) include evidence-based practices and procedures that prevent infection. Among the current guidance for preventing HCAIs is evidence and mandatory requirements for reducing needle stick injuries (NSIs). This article highlights how John Kotter's model for change could help healthcare workers plan for successful and sustained deployment of needle safety devices (NSDs) and ultimately reduce the risk of a NSI.
September 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/29306225/an-examination-of-healthcare-associated-infections-in-elderly-patients
#9
Serap İskender, Gürdal Yılmaz, İftihar Köksal
Background/aim: Healthcare-associated infections (HCAIs) are increasing due to the growing numbers of elderly people requiring long-term care and immunosuppressive therapies. The purpose of this study was to examine HCAIs occurring in elderly inpatients in our hospital.Materials and methods: This study prospectively investigated HCAIs developing in all patients hospitalized over a 1-year period. Diagnosis was based on Centers for Disease Control criteria. The results were subjected to statistical analysis between patients aged over and under 65...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29125365/assessing-students-knowledge-of-healthcare-associated-infections-a-global-perspective
#10
Osarhumwese Osaretin Ojo, Omorogieva Ojo
The aim of this review was to explore students' knowledge of healthcare-associated infections (HCAIs) from a global perspective. HCAIs may be the result of treatment in or contact with healthcare or social care settings and have been shown to cause an increase in morbidity, mortality and increased length of hospital stay. Student placements may involve interactions between university students, patients and/or health professionals and this may be a source of cross-contamination of the microbial agents that cause HCAIs...
November 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28989506/twoc-around-the-clock-a-multimodal-approach-to-improving-catheter-care
#11
Carolyn H Dawson, Melanie Gallo, Kate Prevc
BACKGROUND: Urinary tract infections (UTI) are the second-largest group of healthcare-associated infections (HCAI). The Saving Lives Urinary Catheter Care Bundle was introduced to reduce catheter-associated urinary tract infections (CAUTI). In response, we implemented a catheter care group to examine ways to improve catheter care in an acute hospital NHS Trust. METHODS: We adopted a multimodal approach, revolving around four components: (1) Catheter Care Pathway; (2) HOUDINI checklist; (3) catheter magnets; and (4) use of bladder ultrasound scanners...
March 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/28892887/active-surveillance-of-health-care-associated-infections-in-neurosurgical-patients
#12
Reshu Agarwal, Sarita Mohapatra, Girija Prasad Rath, Arti Kapil
INTRODUCTION: Health Care Associated Infections (HCAI) are frequent complications in neurosurgery. There is limited data available on the incidence and burden of HCAI in neurosurgical patients of Southeast Asian region. AIM: To identify various HCAIs, associated aetiological agents and their antimicrobial susceptibility pattern among the patients admitted in the neurosurgery unit. MATERIALS AND METHODS: An observational prospective study was carried out for three months duration on all neurosurgical patients admitted to a tertiary-care center...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28871825/the-effects-of-ex-vivo-ozone-treatment-on-human-erythrocyte-carbonic-anhydrase-enzyme
#13
Gülten Erken, Haydar Ali Erken, Cigdem Bilen, Nahit Gencer
Ozone autohemotherapy is used in the treatment of some diseases. Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes and play a role in homeostatic mechanisms. The aim of this study was to investigate the effects of ozone on human red blood cell CA (hCA) enzyme activity. Blood samples were treated with different doses of ozone (10, 20, 30 µg/ml) and the erythrocyte total CA activities were determined. Also, purified hCAI and hCAII isozymes were treated with the same doses of ozone and the enzyme activities were measured...
September 5, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28859352/new-approaches-to-prevent-healthcare-associated-infection
#14
Philippe Brouqui, Sophia Boudjema, Alberto Soto Aladro, Eric Chabrière, Olga Florea, Hoa Nguyen, Jean Charles Dufour
Healthcare-associated infection (HCAI) in hospitals mainly results from unsolved but well-identified causes such as hand hygiene, overuse of catheters, and to a lesser extent, the airborne transmission of infectious agents caused by the misuse of respiratory precautions. The aims of the Institut Hospitalo-Universitaire Méditerranée Infection are to develop new approaches to fight HCAIs. Among them, new technologies that allow for the traceability of care and good practices reminders have been developed concomitantly to an anthropological approach, facilitating acceptability by healthcare workers...
August 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28802173/fungicidal-activity-of-copper-sputtered-flexible-surfaces-under-dark-and-actinic-light-against-azole-resistant-candida-albicans-and-candida-glabrata
#15
Myriam K S Ballo, Sami Rtimi, John Kiwi, César Pulgarin, José M Entenza, Alain Bizzini
Candida spp. are able to survive on hospital surfaces and causes healthcare-associated infections (HCAIs). Since surface cleaning and disinfecting interventions are not totally effective to eliminate Candida spp., new approaches should be devised. Copper (Cu) has widely recognized antifungal activity and the use of Cu-sputtered surfaces has recently been proposed to curb the spread of HCAIs. Moreover, the activity of Cu under the action of actinic light remains underexplored. We investigated the antifungal activity of Cu-sputtered polyester surfaces (Cu-PES) against azole-resistant Candida albicans and Candida glabrata under dark and low intensity visible light irradiation (4...
September 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28660816/the-role-of-antimicrobial-sutures-in-preventing-surgical-site-infection
#16
REVIEW
D Leaper, P Wilson, O Assadian, C Edmiston, M Kiernan, A Miller, G Bond-Smith, J Yap
INTRODUCTION Healthcare associated infections (HCAIs) are falling following widespread and enforced introduction of guidelines, particularly those that have addressed antibiotic resistant pathogens such as methicillin resistant Staphylococcus aureus or emergent pathogens such as Clostridium difficile, but no such decline has been seen in the incidence of surgical site infection (SSI), either in the UK, the EU or the US. SSI is one of the HCAIs, which are all avoidable complications of a surgical patient's pathway through both nosocomial and community care...
July 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28638594/high-burden-of-antimicrobial-resistance-among-gram-negative-bacteria-causing-healthcare-associated-infections-in-a-critical-care-unit-of-nepal
#17
Narayan Prasad Parajuli, Subhash Prasad Acharya, Shyam Kumar Mishra, Keshab Parajuli, Basista Prasad Rijal, Bharat Mani Pokhrel
BACKGROUND: Healthcare associated infections (HCAI) and antimicrobial resistance are principal threats to the patients of intensive care units and are the major determining factors for patient outcome. They are associated with increased morbidity, mortality, excess hospitalization and financial costs. The present study is an attempt to investigate the spectrum and antimicrobial resistance of bacterial isolates involved in healthcare associated infections (HCAI) in the patients of a critical care unit at a tertiary care university hospital in Kathmandu, Nepal...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28571171/a-goal-unrealized-patient-empowerment-on-hand-hygiene-a-web-based-survey-from-india
#18
S Vijayalakshmi, S Ramkumar, K A Narayan, P Vaithiyanathan
INTRODUCTION: Each year, millions of patients around the world are affected by Health Care Associated Infections (HCAIs). Understanding and assessing the global burden of HCAI is one of the key areas of work to improve the hand hygiene. AIM: To assess the patient empowerment and awareness on hand hygiene among online users. MATERIALS AND METHODS: A web-based cross-sectional survey was conducted during September 2013 to December 2013 among adults...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28549880/risk-factors-for-health-care-associated-infections-from-better-knowledge-to-better-prevention
#19
Etelvina Ferreira, Elaine Pina, Mafalda Sousa-Uva, António Sousa-Uva
BACKGROUND: Health care-associated infections (HCAIs) are preventable with adoption of recognized preventive measures. The first step is to identify patients at higher risk of HCAI. This study aimed to identify patient risk factors (RFs) present on admission and acquired during inpatient stay which could be associated with higher risk of acquiring HCAI. METHODS: A case-control study was conducted in adult patients admitted during 2011 who were hospitalized for >48 hours...
October 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28483725/opportunities-for-system-level-improvement-in-antibiotic-use-across-the-surgical-pathway
#20
REVIEW
E Charani, R Ahmad, C Tarrant, G Birgand, A Leather, M Mendelson, S R Moonesinghe, N Sevdalis, S Singh, A Holmes
Optimizing antibiotic prescribing across the surgical pathway (before, during, and after surgery) is a key aspect of tackling important drivers of antimicrobial resistance and simultaneously decreasing the burden of infection at the global level. In the UK alone, 10 million patients undergo surgery every year, which is equivalent to 60% of the annual hospital admissions having a surgical intervention. The overwhelming majority of surgical procedures require effectively limited delivery of antibiotic prophylaxis to prevent infections...
July 2017: International Journal of Infectious Diseases: IJID
keyword
keyword
51674
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"