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membrane diffusing capacity

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https://www.readbyqxmd.com/read/28303361/human-topoisomerase-inhibition-and-dna-bsa-binding-of-ru-ii-scar-complexes-as-potential-anticancer-candidates-for-oral-application
#1
Rone A De Grandis, Mariana S de Camargo, Monize M da Silva, Érica O Lopes, Elias C Padilha, Flávia A Resende, Rosângela G Peccinini, Fernando R Pavan, Alessandro Desideri, Alzir A Batista, Eliana A Varanda
Three ruthenium(II) phosphine/diimine/picolinate complexes were selected aimed at investigating anticancer activity against several cancer cell lines and the capacity of inhibiting the supercoiled DNA relaxation mediated by human topoisomerase IB (Top 1). The structure-lipophilicity relationship in membrane permeability using the Caco-2 cells have also been evaluated in this study. SCAR 5 was found to present 45 times more cytotoxicity against breast cancer cell when compared to cisplatin. SCAR 4 and 5 were both found to be capable of inhibiting the supercoiled DNA relaxation mediated by Top 1...
March 16, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28293753/cd16-positive-circulating-monocytes-and-fibrotic-manifestations-of-systemic-sclerosis
#2
Alain Lescoat, Valérie Lecureur, Mikael Roussel, Béatrice Ly Sunnaram, Alice Ballerie, Guillaume Coiffier, Stéphane Jouneau, Olivier Fardel, Thierry Fest, Patrick Jégo
The objective of this study is to assess the association of clinical manifestations of systemic sclerosis (SSc) with the absolute count of circulating blood monocyte subpopulations according to their membrane expression of CD16. Forty-eight consecutive patients fulfilling the 2013 ACR/EULAR classification criteria for SSc were included in this cross-sectional study. CD16+ monocyte absolute count was defined by flow cytometry and confronted to the clinical characteristics of SSc patients. Twenty-three healthy donors (HD) were randomly selected for comparison...
March 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28287506/assessment-of-pulmonary-capillary-blood-volume-membrane-diffusing-capacity-and-intrapulmonary-arteriovenous-anastomoses-during-exercise
#3
Vincent Tedjasaputra, Sean van Diepen, Sophie É Collins, Wade M Michaelchuk, Michael K Stickland
Exercise is a stress to the pulmonary vasculature. With incremental exercise, the pulmonary diffusing capacity (DLCO) must increase to meet the increased oxygen demand; otherwise, a diffusion limitation may occur. The increase in DLCO with exercise is due to increased capillary blood volume (Vc) and membrane diffusing capacity (Dm). Vc and Dm increase secondary to the recruitment and distension of pulmonary capillaries, increasing the surface area for gas exchange and decreasing pulmonary vascular resistance, thereby attenuating the increase in pulmonary arterial pressure...
February 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28249804/hypothesis-why-%C3%AE-no-could-be-finite-in-vitro-but-infinite-in-vivo
#4
Colin Borland, Suhani Patel, Qingyu Zhu, Alain Vuylsteke
There is controversy as to whether the lung Diffusing Capacity for Nitric Oxide (DLNO) is a direct measure of DM in the Roughton-Forster equation or whether θNO is finite and DM is greater than DLNO. Despite in vitro evidence that θNO is finite, some groups believe that it is infinite in vivo and that DMNO/DMCO (α) is greater than predicted by the combined Fick/Graham law of Gas Diffusion through a membrane. We here present a hypothesis applying the fundamental rules of combined diffusion and chemical reaction to a red cell to explain (i) why θNO could be finite in vitro but effectively infinite in vivo and (ii) why ∝ could appear greater than predicted...
February 26, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28223209/langmuir-schaefer-film-deposition-onto-honeycomb-porous-films-for-retinal-tissue-engineering
#5
Maria Teresa Calejo, Tanja Ilmarinen, Elina Vuorimaa-Laukkanen, Elina Talvitie, Hanna M Hakola, Heli Skottman, Minna Kellomäki
Age-related macular degeneration (AMD) is the leading cause of vision loss in senior citizens in the developed world. The disease is characterised by the degeneration of a specific cell layer at the back of the eye - the retinal pigment epithelium (RPE), which is essential in retinal function. The most promising therapeutic option to restore the lost vision is considered to be RPE cell transplantation. This work focuses on the development of biodegradable biomaterials with similar properties to the native Bruch's membrane as carriers for RPE cells...
February 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28179436/standardisation-and-application-of-the-single-breath-determination-of-nitric-oxide-uptake-in-the-lung
#6
Gerald S Zavorsky, Connie C W Hsia, J Michael B Hughes, Colin D R Borland, Hervé Guénard, Ivo van der Lee, Irene Steenbruggen, Robert Naeije, Jiguo Cao, Anh Tuan Dinh-Xuan
Diffusing capacity of the lung for nitric oxide (DLNO), otherwise known as the transfer factor, was first measured in 1983. This document standardises the technique and application of single-breath DLNO This panel agrees that 1) pulmonary function systems should allow for mixing and measurement of both nitric oxide (NO) and carbon monoxide (CO) gases directly from an inspiratory reservoir just before use, with expired concentrations measured from an alveolar "collection" or continuously sampled via rapid gas analysers; 2) breath-hold time should be 10 s with chemiluminescence NO analysers, or 4-6 s to accommodate the smaller detection range of the NO electrochemical cell; 3) inspired NO and oxygen concentrations should be 40-60 ppm and close to 21%, respectively; 4) the alveolar oxygen tension (PAO2 ) should be measured by sampling the expired gas; 5) a finite specific conductance in the blood for NO (θNO) should be assumed as 4...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28161679/recovery-of-ammonia-from-domestic-wastewater-effluents-as-liquid-fertilizers-by-integration-of-natural-zeolites-and-hollow-fibre-membrane-contactors
#7
I Sancho, E Licon, C Valderrama, N de Arespacochaga, S López-Palau, J L Cortina
The integration of up-concentration processes to increase the efficiency of primary sedimentation, as a solution to achieve energy neutral wastewater treatment plants, requires further post-treatment due to the missing ammonium removal stage. This study evaluated the use of zeolites as a post-treatment step, an alternative to the biological removal process. A natural granular clinoptilolite zeolite was evaluated as a sorbent media to remove low levels (up to 100mg-N/L) of ammonium from treated wastewater using batch and fixed bed columns...
April 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28089275/microfluidic-membrane-suppressor-module-design-and-evaluation-for-capillary-ion-chromatography
#8
Sam Wouters, Cees Bruggink, Yury Agroskin, Christopher Pohl, Sebastiaan Eeltink
A microfluidic ion-suppression module for use in ion-exchange chromatography has been developed and evaluated. The device consists of an ion-exchange membrane clamped between two polymer chips featuring a 200×100μm (width×depth) eluent channel (l=60mm), and a 300×150μm regenerant channel (60mm), respectively. The suppression efficacy using a Nafion membrane was compared with that of a styrene-sulfonate grafted fluorinated ethylene propylene (FEP) membrane. The latter was found to outperform Nafion in terms of lowest attainable background signal (suppression efficacy) and dynamic suppression range...
February 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28088638/the-dlno-dlco-ratio-physiological-significance-and-clinical-implications
#9
J M B Hughes, A T Dinh-Xuan
DLNO/DLCO directly measures the ratio of the diffusing capacities of the lung for nitric oxide (NO) and carbon monoxide (CO). In terms of the Roughton and Forster (1957) equation, 1/DL=1/Dm+1/θVc, where Dm is the membrane (Dm) and θVc is the red cell component of the overall diffusing conductance (DL); DLNO mostly reflects the Dm component and DLCO the θVc red cell component. The DLNO/DLCO ratio is positively related to the DmCO/Vc ratio and the CO red cell resistance (1/θCOVc) as a percentage of the total resistance (1/DLCO), independent of the absolute values of DLNO or DLCO...
January 11, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28053522/do-nanoparticles-provide-a-new-opportunity-for-diagnosis-of-distal-airspace-disease
#10
Jakob Löndahl, Jonas Kf Jakobsson, David M Broday, H Laura Aaltonen, Per Wollmer
There is a need for efficient techniques to assess abnormalities in the peripheral regions of the lungs, for example, for diagnosis of pulmonary emphysema. Considerable scientific efforts have been directed toward measuring lung morphology by studying recovery of inhaled micron-sized aerosol particles (0.4-1.5 µm). In contrast, it is suggested that the recovery of inhaled airborne nanoparticles may be more useful for diagnosis. The objective of this work is to provide a theoretical background for the use of nanoparticles in measuring lung morphology and to assess their applicability based on a review of the literature...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28018177/heterocellular-contacts-with-mouse-brain-endothelial-cells-via-laminin-and-%C3%AE-6%C3%AE-1-integrin-sustain-subventricular-zone-svz-stem-progenitor-cells-properties
#11
Alexandra I Rosa, Sofia Grade, Sofia D Santos, Liliana Bernardino, Thomas C Chen, João Relvas, Florence M Hofman, Fabienne Agasse
Neurogenesis in the subventricular zone (SVZ) is regulated by diffusible factors and cell-cell contacts. In vivo, SVZ stem cells are associated with the abluminal surface of blood vessels and such interactions are thought to regulate their neurogenic capacity. SVZ neural stem cells (NSCs) have been described to contact endothelial-derived laminin via α6β1 integrin. To elucidate whether heterocellular contacts with brain endothelial cells (BEC) regulate SVZ cells neurogenic capacities, cocultures of SVZ neurospheres and primary BEC, both obtained from C57BL/6 mice, were performed...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28013060/the-blood-transfer-conductance-for-nitric-oxide-infinite-vs-finite-%C3%AE-no
#12
Kirsten E Coffman, Steven C Chase, Bryan J Taylor, Bruce D Johnson
Whether the specific blood transfer conductance for nitric oxide (NO) with hemoglobin (θNO) is finite or infinite is controversial but important in the calculation of alveolar capillary membrane conductance (DmCO) and pulmonary capillary blood volume (VC) from values of lung diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO). In this review, we discuss the background associated with θNO, explore the resulting values of DmCO and VC when applying either assumption, and investigate the mathematical underpinnings of DmCO and VC calculations...
December 21, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27976860/voltammetric-thin-layer-ionophore-based-films-part-2-semi-empirical-treatment
#13
Dajing Yuan, Maria Cuartero, Gaston A Crespo, Eric Bakker
This work reports on a semiempirical treatment that allows one to rationalize and predict experimental conditions for thin-layer ionophore-based films with cation-exchange capacity read out with cyclic voltammetry. The transition between diffusional mass transport and thin-layer regime is described with a parameter (α), which depends on membrane composition, diffusion coefficient, scan rate, and electrode rotating speed. Once the thin-layer regime is fulfilled (α = 1), the membrane behaves in some analogy to a potentiometric sensor with a second discrimination variable (the applied potential) that allows one to operate such electrodes in a multianalyte detection mode owing to the variable applied ion-transfer potentials...
December 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27976858/voltammetric-thin-layer-ionophore-based-films-part-1-experimental-evidence-and-numerical-simulations
#14
Dajing Yuan, Maria Cuartero, Gaston A Crespo, Eric Bakker
Voltammetric thin layer (∼200 nm) ionophore-based polymeric films of defined ion-exchange capacity have recently emerged as a promising approach to acquire multi-ion information about the sample, in analogy to performing multiple potentiometric measurements with individual membranes. They behave under two different regimes that are dependent on the ion concentration. A thin layer control (no mass transport limitation of the polymer film or solution) is identified for ion concentrations of >10 μM, in which case the peak potential serves as the readout signal, in analogy to a potentiometric sensor...
December 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27976398/pushing-it-to-the-limit-enhanced-diffusing-membrane-capacity-facilitates-greater-pulmonary-diffusing-capacity-in-athletes-during-exercise
#15
Leah Groves, Sara Brade, Stephen P Wright
No abstract text is available yet for this article.
December 15, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27932673/are-there-sex-differences-in-the-capillary-blood-volume-and-diffusing-capacity-response-to-exercise
#16
Melissa M Bouwsema, Vincent Tedjasaputra, Michael K Stickland
Previous work suggests that women may exhibit a greater respiratory limitation to exercise compared to height-matched men. Diffusion capacity (DLCO) increases with incremental exercise, and the smaller lungs of women may limit membrane diffusing capacity (Dm) and pulmonary capillary blood volume (Vc) in response to the increased oxygen demand. We hypothesized that females would have a lower DLCO, DLCO relative to cardiac output (DLCO/Q), Dm, Vc, and pulmonary transit time, secondary to lower Vc at peak exercise...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27916736/the-history-of-the-pulmonary-diffusing-capacity-for-nitric-oxide-dl-no
#17
Colin Dr Borland, Hervé Guénard
The DL,NO (TL,NO) had its unexpected origins in the Paris "events" of 1968 and the unsuccessful efforts of the UK tobacco industry in the 1970's to create a "safer cigarette". Adoption of the technique has been slow due to the instability of NO in air, lack of standardisation of the technique and lack of agreement as to whether DL,NO is equal to or merely reflects membrane diffusing capacity (DM). With the availability of inexpensive analysers, standardisation of the technique and publication of reference equations we believe that its worldwide use will increase...
December 1, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27911942/persistent-morbillivirus-infection-leads-to-altered-cortactin-distribution-in-histiocytic-sarcoma-cells-with-decreased-cellular-migration-capacity
#18
Vanessa Maria Pfankuche, Mohamed Sayed-Ahmed, Vanessa Bono Contioso, Ingo Spitzbarth, Karl Rohn, Reiner Ulrich, Ulrich Deschl, Arno Kalkuhl, Wolfgang Baumgärtner, Christina Puff
Histiocytic sarcomas represent rare but fatal neoplasms in humans. Based on the absence of a commercially available human histiocytic sarcoma cell line the frequently affected dog displays a suitable translational model. Canine distemper virus, closely related to measles virus, is a highly promising candidate for oncolytic virotherapy. Therapeutic failures in patients are mostly associated with tumour invasion and metastasis often induced by misdirected cytoskeletal protein activities. Thus, the impact of persistent canine distemper virus infection on the cytoskeletal protein cortactin, which is frequently overexpressed in human cancers with poor prognosis, was investigated in vitro in a canine histiocytic sarcoma cell line (DH82)...
2016: PloS One
https://www.readbyqxmd.com/read/27890359/selective-removal-of-cesium-by-ammonium-molybdophosphate-polyacrylonitrile-bead-and-membrane
#19
Dahu Ding, Zhenya Zhang, Rongzhi Chen, Tianming Cai
The selective removal of radionuclides with extremely low concentrations from environmental medium remains a big challenge. Ammonium molybdophosphate possess considerable selectivity towards cesium ion (Cs(+)) due to the specific ion exchange between Cs(+) and NH4(+). Ammonium molybdophosphate - polyacrylonitrile (AMP-PAN) membrane was successfully prepared for the first time in this study. Efficient removal of Cs(+) (95.7%, 94.1% and 91.3% of 1mgL(-1)) from solutions with high ionic strength (400mgL(-1) of Na(+), Ca(2+) or K(+)) was achieved by AMP-PAN composite...
February 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27863863/effect-of-%C3%AE-2-adrenergic-receptor-stimulation-on-lung-fluid-in-stable-heart-failure-patients
#20
Bryan J Taylor, Eric M Snyder, Maile L Richert, Courtney M Wheatley, Steven C Chase, Lyle J Olson, Bruce D Johnson
BACKGROUND: The purpose of this study was to determine: (1) whether stable heart failure patients with reduced ejection fraction (HFrEF) have elevated extravascular lung water (EVLW) when compared with healthy control subjects; and (2) the effect of acute β2-adrenergic receptor (β2AR) agonist inhalation on lung fluid balance. METHODS: Twenty-two stable HFrEF patients and 18 age- and gender-matched healthy subjects were studied. Lung diffusing capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO), pulmonary capillary blood volume (Vc) (via re-breathe) and lung tissue volume (Vtis) (via computed tomography) were assessed before and within 30 minutes after administration of nebulized albuterol...
October 2, 2016: Journal of Heart and Lung Transplantation
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