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https://www.readbyqxmd.com/read/28099975/functional-outcome-of-cad-cam-assisted-versus-conventional-microvascular-fibular-free-flap-reconstruction-of-the-mandible-a-retrospective-study-of-30-cases
#1
Lucas M Ritschl, Thomas Mücke, Andreas Fichter, Florian D Güll, Christopher Schmid, Jean Marc Pho Duc, Marco R Kesting, Klaus-Dietrich Wolff, Denys J Loeffelbein
Background Different advantages of virtually planned and guided mandibular reconstructions have been described. Functional analyses and comparisons with conventionally reconstructed patients. Methods We retrospectively analyzed 30 cases of mandibular reconstructions that involved virtually planned or conventional microvascular, fibular free flaps that occurred between April 2011 and December 2014 at a single center. The results were also compared with a healthy cohort of 30 participants. Axiographic measurements were performed postoperatively, and uni- and multivariate regressions analyses were performed to determine the association between possible predictor variables on functional outcome...
January 18, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/28092457/insulin-sensitivity-and-inflammation-mediate-the-impact-of-fitness-on-cerebrovascular-health-in-adolescents
#2
Po Lai Yau, Naima Ross, Andrew Tirsi, Arslan Arif, Zeynep Ozinci, Antonio Convit
BACKGROUND/OBJECTIVES: To investigate in adolescents the relationships between retinal vessel diameter, physical fitness, insulin sensitivity, and systemic inflammation. METHODS: We evaluated 157 adolescents, 112 with excessive weight and 45 lean, all without type 2 diabetes mellitus. All received detailed evaluations, including measurements of retinal vessel diameter, insulin sensitivity, levels of inflammation, and physical fitness. RESULTS: Overweight/obese adolescents had significantly narrower retinal arteriolar and wider venular diameters, significantly lower insulin sensitivity, and physical fitness...
January 16, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28052811/short-term-outcomes-of-mandibular-reconstruction-in-oncological-patients-using-a-cad-cam-prosthesis-including-a-condyle-supporting-a-fibular-free-flap
#3
Achille Tarsitano, Salvatore Battaglia, Valerio Ramieri, Piero Cascone, Leonardo Ciocca, Roberto Scotti, Claudio Marchetti
PURPOSE: Condylar reconstruction and replacement using alloplastic materials currently attracts much surgical interest. The major challenge is to functionally reconstruct the anatomical region; this is crucial in terms of correct mandibular function. The goal of the present study was to evaluate the clinical outcomes of and complications experienced by a series of oncological patients who underwent computer-aided design/computer-aided manufacturing (CAD/CAM) condylar reconstruction following resection-disarticulation of the mandible...
December 16, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27995558/is-there-benefit-to-free-over-pedicled-vascularized-grafts-in-augmenting-tibial-intercalary-allograft-constructs
#4
Marco Manfrini, Srimanth Bindiganavile, Ferhat Say, Marco Colangeli, Laura Campanacci, Massimiliano Depaolis, Massimo Ceruso, Davide Donati
BACKGROUND: Intercalary reconstruction of tibial sarcomas with vascularized fibula autografts and massive bone allografts is reliable with predictable long-term results. However, inadequate data exist comparing free and pedicled vascularized fibula autografts in combination with a massive bone allograft in patients undergoing intercalary tibia reconstructions. QUESTIONS/PURPOSES: Among patients undergoing large-segment intercalary allografting, we sought to compare supplemental free vascularized fibular autografts with supplemental pedicled vascularized fibular autografts, in terms of (1) oncologic results, (2) complications associated with surgery, (3) Musculoskeletal Tumor Society (MSTS) scores, and (4) surgical time...
December 19, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27987530/obesity-insulin-resistance-and-microvascular-adaptation
#5
Jefferson C Frisbee
Two of the primary risk factors for the progressive evolution of cardiovascular disease are obesity and impaired glycemic control - including both insulin resistance and overt type 2 diabetes mellitus, leading to increased research emphasis on these conditions, their mechanistic bases and their health outcomes. This Special Topics Issue of the journal Microcirculation summarizes a symposium at the recent Joint Meeting of the American Physiological Society and the Physiological Society, held in Dublin, Ireland on July 30, 2016...
December 17, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27811374/prognostic-nomograms-for-patients-with-resectable-hepatocelluar-carcinoma-incorporating-systemic-inflammation-and-tumor-characteristics
#6
Junyi Shen, Linye He, Chuan Li, Tianfu Wen, Weixia Chen, Changli Lu, Lvnan Yan, Bo Li, Jiayin Yang
BACKGROUND: The model to predict the prognosis of resectable hepatocelluar carcinoma (HCC) has not been determined. METHODS: Predictors were selected using Cox model. Nomograms were generated in the training set and validated in the validation set. The predictive ability of the nomogram was determined by concordance index and calibration curve. RESULTS: Independent factors for overall survival including alpha-fetoprotein level (hazard ratio (HR):1...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27673377/soft-tissue-defects-after-total-knee-arthroplasty-management-and-reconstruction
#7
Daniel A Osei, Kelsey A Rebehn, Martin I Boyer
Wound healing complications associated with total knee arthroplasty present a considerable challenge to the orthopaedic surgeon. To ensure preservation of a functional joint, the management of periprosthetic soft-tissue defects around the knee requires rapid assessment, early and aggressive débridement, and durable, contoured coverage. Several reconstructive options are available to tailor soft-tissue coverage to the location, size, and depth of the wound. Special consideration should be given to the timing of the intervention, management of infection, and prosthesis salvage...
November 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27625904/rice-body-formation-within-a-peri-articular-shoulder-mass
#8
Michele N Edison, Anthony Caram, Miguel Flores, Kurt Scherer
Most commonly associated with chronic inflammatory conditions, rice bodies represent an uncommon, nonspecific, often intra-articular inflammatory process. Presumably, rice bodies represent the sequelae of microvascular infarcts of the joint synovium. However, rice bodies have been seen in pleural fluid, in the setting of bursitis, and within the tendon sheath. The etiology and prognostic significance of rice bodies are not clear. MRI is the diagnostic imaging modality of choice for the evaluation of rice body formation...
2016: Curēus
https://www.readbyqxmd.com/read/27497856/thrombotic-microangiopathy-care-pathway-a-consensus-statement-for-the-mayo-clinic-complement-alternative-pathway-thrombotic-microangiopathy-cap-tma-disease-oriented-group
#9
Ronald S Go, Jeffrey L Winters, Nelson Leung, David L Murray, Maria A Willrich, Roshini S Abraham, Hatem Amer, William J Hogan, Ariela L Marshall, Sanjeev Sethi, Cheryl L Tran, Dong Chen, Rajiv K Pruthi, Aneel A Ashrani, Fernando C Fervenza, Carl H Cramer, Vilmarie Rodriguez, Alexandra P Wolanskyj, Stephan D Thomé, C Christopher Hook
Thrombotic microangiopathies (TMAs) comprise a heterogeneous set of conditions linked by a common histopathologic finding of endothelial damage resulting in microvascular thromboses and potentially serious complications. The typical clinical presentation is microangiopathic hemolytic anemia accompanied by thrombocytopenia with varying degrees of organ ischemia. The differential diagnoses are generally broad, while the workup is frequently complex and can be confusing. This statement represents the joint recommendations from a multidisciplinary team of Mayo Clinic physicians specializing in the management of TMA...
September 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27355280/ultrasonography-for-hand-and-wrist-conditions
#10
Harlan M Starr, Matthew D Sedgley, Kenneth R Means, Michael S Murphy
Ultrasonography facilitates dynamic, real-time evaluation of bones, joints, tendons, nerves, and vessels, making it an ideal imaging modality for hand and wrist conditions. Ultrasonography can depict masses and fluid collections, help locate radiolucent foreign bodies, characterize traumatic or overuse tendon or ligament pathology, and help evaluate compressive peripheral neuropathy and microvascular blood flow. Additionally, this modality improves the accuracy of therapeutic intra-articular or peritendinous injections and facilitates aspiration of fluid collections, such as ganglia...
August 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27324400/angioarchitecture-and-morphology-of-temporomandibular-joint-of-monodelphis-domestica
#11
Matheus Silvestre Minucci, João Paulo Mardegan Issa, Fernando Yukio Yokoyama, Fernando José Dias, Daniela Mizusaki Iyomasa, Elaine Aparecida Del-Bel Belluz Guimarães, Ii-Sei Watanabe, Mamie Mizusaki Iyomasa
The opossum Monodelphis domestica presents movement of the temporomandibular joint (TMJ) reflecting adaptation to eating habits similar to movement in humans, but the structure of the TMJ is not yet known. Thus, nine young M. domestica, of both sexes were weighed, anesthetized with xylazine (10 mg kg(-1) ), and ketamine (70 mg kg(-1) ) and processed for: 1. The analyses of the macroscopic angioarchitecture after latex injection, as well as the topography of the TMJ; 2. The analysis of microvascularization after injection of Mercox resin and corrosion of soft tissue with NaOH using scanning electron microscopy and; 3...
September 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27319300/morphological-study-of-the-articular-disc-and-capillary-of-the-retrodiscal-tissue-in-a-type-2-spontaneous-diabetes-mellitus-rat-model
#12
Mamoru Uemura, Isumi Toda, Wataru Kawashima, Gaku Yoshimoto, Yi-Ru Fang, Yuan Jin Xu, Yuan Liu, Lei Zhang, Akimichi Takemura
The objective of this study was to evaluate morphological changes at the articular disc of the temporomandibular joint and capillary of the retrodiscal tissue in a rat model for type 2 spontaneous diabetes mellitus (DM) (i.e., Goto-Kakizaki [GK] rats) compared to normal Wistar rats. A total of 20 experimental rats were used in this study; the rats were categorized into the normal (n = 10 male 8-week-old Wistar rats) and DM (n = 10 male 8-week-old GK rats) groups. Hematoxylin-eosin stained specimens were obtained from 5 rats from each group...
2016: Okajimas Folia Anatomica Japonica
https://www.readbyqxmd.com/read/27313886/maximizing-outcomes-while-minimizing-morbidity-an-illustrated-case-review-of-elbow-soft-tissue-reconstruction
#13
Adrian Ooi, Jonathan Ng, Christopher Chui, Terence Goh, Bien Keem Tan
Background. Injuries to the elbow have led to consequences varying from significant limitation in function to loss of the entire upper limb. Soft tissue reconstruction with durable and pliable coverage balanced with the ability to mobilize the joint early to optimize rehabilitation outcomes is paramount. Methods. Methods of flap reconstruction have evolved from local and pedicled flaps to perforator-based flaps and free tissue transfer. Here we performed a review of 20 patients who have undergone flap reconstruction of the elbow at our institution...
2016: Plastic Surgery International
https://www.readbyqxmd.com/read/27273133/joint-effect-of-early-microvascular-damage-in-the-eye-kidney-on-risk-of-cardiovascular-events
#14
Wanfen Yip, Charumathi Sabanayagam, Peng Guan Ong, Uptal D Patel, Khuan Yew Chow, E Shyong Tai, Lieng H Ling, Tien Yin Wong, Carol Yim-Lui Cheung
Microalbuminuria is associated with an increased risk of cardiovascular disease (CVD), but not all individuals require treatment. Retinal microvascular abnormalities and microalbuminuria reflect early systemic microvascular changes. We examined the joint effect of retinal abnormalities and microalbuminuria on CVD risk in an Asian cohort. We conducted a prospective, population-based study. Retinal abnormalities were defined as presence of retinopathy and/or retinal venular widening. Microalbuminuria was defined as urinary albumin: creatinine ratio between 30-300 mg/g...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27164349/association-of-wolfram-syndrome-with-fallot-tetralogy-in-a-girl
#15
Hüseyin A Korkmaz, Korcan Demir, Filiz Hazan, Melek Yıldız, Özlem N Elmas, Behzat Özkan
Wolfram syndrome (DIDMOAD: diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is a rare neurodegenerative disorder. Mutations of the WFS1 (wolframin) on chromosome 4 are responsible for the clinical manifestations in majority of patients with Wolfram syndrome. Wolfram syndrome is also accompanied by neurologic and psychiatric disorders, urodynamic abnormalities, restricted joint motility, cardiovascular and gastrointestinal autonomic neuropathy, hypergonadotrophic hypogonadism in males and diabetic microvascular disorders...
June 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27013493/dysregulated-bioenergetics-a-key-regulator-of-joint-inflammation
#16
M Biniecka, M Canavan, T McGarry, W Gao, J McCormick, S Cregan, L Gallagher, T Smith, J J Phelan, J Ryan, J O'Sullivan, C T Ng, D J Veale, U Fearon
OBJECTIVES: This study examines the relationship between synovial hypoxia and cellular bioenergetics with synovial inflammation. METHODS: Primary rheumatoid arthritis synovial fibroblasts (RASF) were cultured with hypoxia, dimethyloxalylglycine (DMOG) or metabolic intermediates. Mitochondrial respiration, mitochondrial DNA mutations, cell invasion, cytokines, glucose and lactate were quantified using specific functional assays. RASF metabolism was assessed by the XF24-Flux Analyzer...
December 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26952166/quantification-of-microcirculatory-parameters-by-joint-analysis-of-flow-compensated-and-non-flow-compensated-intravoxel-incoherent-motion-ivim-data
#17
André Ahlgren, Linda Knutsson, Ronnie Wirestam, Markus Nilsson, Freddy Ståhlberg, Daniel Topgaard, Samo Lasič
The aim of this study was to improve the accuracy and precision of perfusion fraction and blood velocity dispersion estimates in intravoxel incoherent motion (IVIM) imaging, using joint analysis of flow-compensated and non-flow-compensated motion-encoded MRI data. A double diffusion encoding sequence capable of switching between flow-compensated and non-flow-compensated encoding modes was implemented. In vivo brain data were collected in eight healthy volunteers and processed using the joint analysis. Simulations were used to compare the performance of the proposed analysis method with conventional IVIM analysis...
May 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/26942449/pepito-driven-pedf-expression-ameliorates-diabetic-retinopathy-hallmarks
#18
Sofia M Calado, Francisco Diaz-Corrales, Gabriela A Silva
Diabetic retinopathy (DR) is one of the major complications of diabetes mellitus. It is characterized by retinal microvascular changes caused by chronic exposure to hyperglycemia, leading to low tissue oxygenation and ultimately to neovascularization. Laser photocoagulation and vitrectomy are the most efficient treatments for DR, but display severe side effects such as the destruction of the healthy retina. Another clinical approach uses antiangiogenic agents to prevent and delay progression of neovascularization, but these require recurrent local administrations that increase the possibility of retinal detachment, vitreous hemorrhage, and cataract formation...
April 2016: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/26869203/a-semi-synthetic-natural-product-blocks-collagen-induced-arthritis-by-preferentially-suppressing-the-production-of-il-6
#19
Asha Kulkarni-Almeida, Meet Shah, Mahesh Jadhav, Bindu Hegde, Jacqueline Trivedi, Prabhu D Mishra, Girish B Mahajan, Shruta Dadarkar, Ravindra Gupte, Nilesh Dagia
Rheumatoid arthritis (RA), an autoimmune-inflammatory disease is characterized by dysregulation of signal transduction pathways, increased production of pro-inflammatory cytokines, enhanced leukocyte infiltration into synovial microvascular endothelium, extensive formation of hyper proliferative pannus, degradation of cartilage and bone erosion. Several compounds that abrogate cytokine production demonstrate a therapeutic effect in experimental models of arthritis. In this study, we report that a novel semi-synthetic natural product (Compound A) being a preferential IL-6 inhibitor, is efficacious in a murine model of arthritis...
April 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/26808773/heterotopic-vascularized-joint-transfer-in-mutilating-hand-injuries
#20
Nai-Jen Chang, Johnny T Chang, Chung-Chen Hsu, Cheng-Hung Lin, Chih-Hung Lin, Yu-Te Lin
BACKGROUND: In cases of mutilating hand injuries, the primary goal is recovery of prehensile function. This is particularly true in the case of joints, which are extremely difficult to replace or reconstruct adequately when damaged. Heterotopic vascularized joint transfer is indicated when salvageable joints are available for transfer to a more functionally optimal position on the hand. MATERIALS AND METHODS: Seven cases of mutilating hand injuries treated with heterotopic vascularized joint transfers from 2003 to 2012 were retrospectively identified...
March 2016: Annals of Plastic Surgery
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