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microvascularized joint

Daniel A Osei, Kelsey A Rebehn, Martin I Boyer
Wound healing complications associated with total knee arthroplasty present a considerable challenge to the orthopaedic surgeon. To ensure preservation of a functional joint, the management of periprosthetic soft-tissue defects around the knee requires rapid assessment, early and aggressive débridement, and durable, contoured coverage. Several reconstructive options are available to tailor soft-tissue coverage to the location, size, and depth of the wound. Special consideration should be given to the timing of the intervention, management of infection, and prosthesis salvage...
November 2016: Journal of the American Academy of Orthopaedic Surgeons
Michele N Edison, Anthony Caram, Miguel Flores, Kurt Scherer
Most commonly associated with chronic inflammatory conditions, rice bodies represent an uncommon, nonspecific, often intra-articular inflammatory process. Presumably, rice bodies represent the sequelae of microvascular infarcts of the joint synovium. However, rice bodies have been seen in pleural fluid, in the setting of bursitis, and within the tendon sheath. The etiology and prognostic significance of rice bodies are not clear. MRI is the diagnostic imaging modality of choice for the evaluation of rice body formation...
2016: Curēus
Ronald S Go, Jeffrey L Winters, Nelson Leung, David L Murray, Maria A Willrich, Roshini S Abraham, Hatem Amer, William J Hogan, Ariela L Marshall, Sanjeev Sethi, Cheryl L Tran, Dong Chen, Rajiv K Pruthi, Aneel A Ashrani, Fernando C Fervenza, Carl H Cramer, Vilmarie Rodriguez, Alexandra P Wolanskyj, Stephan D Thomé, C Christopher Hook
Thrombotic microangiopathies (TMAs) comprise a heterogeneous set of conditions linked by a common histopathologic finding of endothelial damage resulting in microvascular thromboses and potentially serious complications. The typical clinical presentation is microangiopathic hemolytic anemia accompanied by thrombocytopenia with varying degrees of organ ischemia. The differential diagnoses are generally broad, while the workup is frequently complex and can be confusing. This statement represents the joint recommendations from a multidisciplinary team of Mayo Clinic physicians specializing in the management of TMA...
September 2016: Mayo Clinic Proceedings
Harlan M Starr, Matthew D Sedgley, Kenneth R Means, Michael S Murphy
Ultrasonography facilitates dynamic, real-time evaluation of bones, joints, tendons, nerves, and vessels, making it an ideal imaging modality for hand and wrist conditions. Ultrasonography can depict masses and fluid collections, help locate radiolucent foreign bodies, characterize traumatic or overuse tendon or ligament pathology, and help evaluate compressive peripheral neuropathy and microvascular blood flow. Additionally, this modality improves the accuracy of therapeutic intra-articular or peritendinous injections and facilitates aspiration of fluid collections, such as ganglia...
August 2016: Journal of the American Academy of Orthopaedic Surgeons
Matheus Silvestre Minucci, João Paulo Mardegan Issa, Fernando Yukio Yokoyama, Fernando José Dias, Daniela Mizusaki Iyomasa, Elaine Aparecida Del-Bel Belluz Guimarães, Ii-Sei Watanabe, Mamie Mizusaki Iyomasa
The opossum Monodelphis domestica presents movement of the temporomandibular joint (TMJ) reflecting adaptation to eating habits similar to movement in humans, but the structure of the TMJ is not yet known. Thus, nine young M. domestica, of both sexes were weighed, anesthetized with xylazine (10 mg kg(-1) ), and ketamine (70 mg kg(-1) ) and processed for: 1. The analyses of the macroscopic angioarchitecture after latex injection, as well as the topography of the TMJ; 2. The analysis of microvascularization after injection of Mercox resin and corrosion of soft tissue with NaOH using scanning electron microscopy and; 3...
September 2016: Microscopy Research and Technique
Mamoru Uemura, Isumi Toda, Wataru Kawashima, Gaku Yoshimoto, Yi-Ru Fang, Yuan Jin Xu, Yuan Liu, Lei Zhang, Akimichi Takemura
The objective of this study was to evaluate morphological changes at the articular disc of the temporomandibular joint and capillary of the retrodiscal tissue in a rat model for type 2 spontaneous diabetes mellitus (DM) (i.e., Goto-Kakizaki [GK] rats) compared to normal Wistar rats. A total of 20 experimental rats were used in this study; the rats were categorized into the normal (n = 10 male 8-week-old Wistar rats) and DM (n = 10 male 8-week-old GK rats) groups. Hematoxylin-eosin stained specimens were obtained from 5 rats from each group...
2016: Okajimas Folia Anatomica Japonica
Adrian Ooi, Jonathan Ng, Christopher Chui, Terence Goh, Bien Keem Tan
Background. Injuries to the elbow have led to consequences varying from significant limitation in function to loss of the entire upper limb. Soft tissue reconstruction with durable and pliable coverage balanced with the ability to mobilize the joint early to optimize rehabilitation outcomes is paramount. Methods. Methods of flap reconstruction have evolved from local and pedicled flaps to perforator-based flaps and free tissue transfer. Here we performed a review of 20 patients who have undergone flap reconstruction of the elbow at our institution...
2016: Plastic Surgery International
Wanfen Yip, Charumathi Sabanayagam, Peng Guan Ong, Uptal D Patel, Khuan Yew Chow, E Shyong Tai, Lieng H Ling, Tien Yin Wong, Carol Yim-Lui Cheung
Microalbuminuria is associated with an increased risk of cardiovascular disease (CVD), but not all individuals require treatment. Retinal microvascular abnormalities and microalbuminuria reflect early systemic microvascular changes. We examined the joint effect of retinal abnormalities and microalbuminuria on CVD risk in an Asian cohort. We conducted a prospective, population-based study. Retinal abnormalities were defined as presence of retinopathy and/or retinal venular widening. Microalbuminuria was defined as urinary albumin: creatinine ratio between 30-300 mg/g...
2016: Scientific Reports
Hüseyin A Korkmaz, Korcan Demir, Filiz Hazan, Melek Yıldız, Özlem N Elmas, Behzat Özkan
Wolfram syndrome (DIDMOAD: diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is a rare neurodegenerative disorder. Mutations of the WFS1 (wolframin) on chromosome 4 are responsible for the clinical manifestations in majority of patients with Wolfram syndrome. Wolfram syndrome is also accompanied by neurologic and psychiatric disorders, urodynamic abnormalities, restricted joint motility, cardiovascular and gastrointestinal autonomic neuropathy, hypergonadotrophic hypogonadism in males and diabetic microvascular disorders...
June 1, 2016: Archivos Argentinos de Pediatría
M Biniecka, M Canavan, T McGarry, W Gao, J McCormick, S Cregan, L Gallagher, T Smith, J J Phelan, J Ryan, J O'Sullivan, C T Ng, D J Veale, U Fearon
OBJECTIVES: This study examines the relationship between synovial hypoxia and cellular bioenergetics with synovial inflammation. METHODS: Primary rheumatoid arthritis synovial fibroblasts (RASF) were cultured with hypoxia, dimethyloxalylglycine (DMOG) or metabolic intermediates. Mitochondrial respiration, mitochondrial DNA mutations, cell invasion, cytokines, glucose and lactate were quantified using specific functional assays. RASF metabolism was assessed by the XF24-Flux Analyzer...
March 24, 2016: Annals of the Rheumatic Diseases
André Ahlgren, Linda Knutsson, Ronnie Wirestam, Markus Nilsson, Freddy Ståhlberg, Daniel Topgaard, Samo Lasič
The aim of this study was to improve the accuracy and precision of perfusion fraction and blood velocity dispersion estimates in intravoxel incoherent motion (IVIM) imaging, using joint analysis of flow-compensated and non-flow-compensated motion-encoded MRI data. A double diffusion encoding sequence capable of switching between flow-compensated and non-flow-compensated encoding modes was implemented. In vivo brain data were collected in eight healthy volunteers and processed using the joint analysis. Simulations were used to compare the performance of the proposed analysis method with conventional IVIM analysis...
May 2016: NMR in Biomedicine
Sofia M Calado, Francisco Diaz-Corrales, Gabriela A Silva
Diabetic retinopathy (DR) is one of the major complications of diabetes mellitus. It is characterized by retinal microvascular changes caused by chronic exposure to hyperglycemia, leading to low tissue oxygenation and ultimately to neovascularization. Laser photocoagulation and vitrectomy are the most efficient treatments for DR, but display severe side effects such as the destruction of the healthy retina. Another clinical approach uses antiangiogenic agents to prevent and delay progression of neovascularization, but these require recurrent local administrations that increase the possibility of retinal detachment, vitreous hemorrhage, and cataract formation...
April 2016: Human Gene Therapy Methods
Asha Kulkarni-Almeida, Meet Shah, Mahesh Jadhav, Bindu Hegde, Jacqueline Trivedi, Prabhu D Mishra, Girish B Mahajan, Shruta Dadarkar, Ravindra Gupte, Nilesh Dagia
Rheumatoid arthritis (RA), an autoimmune-inflammatory disease is characterized by dysregulation of signal transduction pathways, increased production of pro-inflammatory cytokines, enhanced leukocyte infiltration into synovial microvascular endothelium, extensive formation of hyper proliferative pannus, degradation of cartilage and bone erosion. Several compounds that abrogate cytokine production demonstrate a therapeutic effect in experimental models of arthritis. In this study, we report that a novel semi-synthetic natural product (Compound A) being a preferential IL-6 inhibitor, is efficacious in a murine model of arthritis...
April 2016: International Immunopharmacology
Nai-Jen Chang, Johnny T Chang, Chung-Chen Hsu, Cheng-Hung Lin, Chih-Hung Lin, Yu-Te Lin
BACKGROUND: In cases of mutilating hand injuries, the primary goal is recovery of prehensile function. This is particularly true in the case of joints, which are extremely difficult to replace or reconstruct adequately when damaged. Heterotopic vascularized joint transfer is indicated when salvageable joints are available for transfer to a more functionally optimal position on the hand. MATERIALS AND METHODS: Seven cases of mutilating hand injuries treated with heterotopic vascularized joint transfers from 2003 to 2012 were retrospectively identified...
March 2016: Annals of Plastic Surgery
Ye-Rang Jang, Kwang-Woong Lee, Hyeyoung Kim, Jeong-Moo Lee, Nam-Joon Yi, Kyung-Suk Suh
BACKGROUNDS/AIMS: In hepatocellular carcinoma (HCC), bile duct invasion occurs far more rarely than vascular invasion and is not well characterized. In addition, the pathologic finding of bile duct invasion is not considered an independent prognostic factor for HCC following surgery. In this study, we determined the characteristics of HCC with bile duct invasion, and assessed the clinical significance of bile duct invasion. METHODS: We retrospectively reviewed the medical records of 363 patients who underwent hepatic resection for HCC at Seoul National University Hospital (SNUH) from January 2009 to December 2011...
November 2015: Korean Journal of Hepato-biliary-pancreatic Surgery
Devender Kumar, Laura C Ristow, Meiqing Shi, Priyanka Mukherjee, Jennifer A Caine, Woo-Yong Lee, Paul Kubes, Jenifer Coburn, George Chaconas
Vascular extravasation, a key step in systemic infection by hematogenous microbial pathogens, is poorly understood, but has been postulated to encompass features similar to vascular transmigration by leukocytes. The Lyme disease spirochete can cause a variety of clinical manifestations, including arthritis, upon hematogenous dissemination. This pathogen encodes numerous surface adhesive proteins (adhesins) that may promote extravasation, but none have yet been implicated in this process. In this work we report the novel use of intravital microscopy of the peripheral knee vasculature to study transmigration of the Lyme spirochete in living Cd1d-/-mice...
December 2015: PLoS Pathogens
Jie Fan, Bingmei M Fu
Tumor cell extravasation through the endothelial barrier forming the microvessel wall is a crucial step during tumor metastasis. However, where, how and how fast tumor cells transmigrate through endothelial barriers remain unclear. Using an in vitro transwell model, we performed a transmigration assay of malignant breast tumor cells (MDA-MB-231) through brain and lung microvascular endothelial monolayers under control and pathological conditions. The locations and rates of tumor cell transmigration as well as the changes in the structural components (integrity) of endothelial monolayers were quantified by confocal microscopy...
July 2016: Annals of Biomedical Engineering
Wenche S Borgnakke, Patricia F Anderson, Carol Shannon, Anca Jivanescu
Diabetic neuropathy is the most common microvascular complication of diabetes mellitus with high morbidity and mortality, and low quality of life. It has a broad spectrum of clinical forms, although distal symmetrical polyneuropathy is the most prevalent. Several oral complications including burning mouth syndrome, dry mouth, and impairment of the senses taste and smell are less-known manifestations of diabetic neuropathy and often overlooked. Periodontitis, tooth loss, and temporomandibular joint dysfunction may be also present in these patients and are equally debilitating...
November 2015: Current Diabetes Reports
Miodrag Dikic, Milorad Tesic, Zeljko Markovic, Vojislav Giga, Ana Djordjevic-Dikic, Jelena Stepanovic, Branko Beleslin, Ivana Jovanovic, Ana Mladenovic, Jelena Seferovic, Miodrag Ostojic, Aleksandra Arandjelovic
BACKGROUND: The risk stratification of patients with diabetes mellitus (DM) is a major objective for the clinicians, and it can be achieved by coronary flow velocity reserve (CFVR) or with coronary artery calcium score (CS). CS evaluates underlying coronary atherosclerotic plaque burden and CFVR estimates both presence of coronary artery stenosis and microvascular function. Consequently, CFVR may provide unique risk information beyond the extent of coronary atherosclerosis. AIM: Our aim is to assess joint prognostic value of CFVR and CS in asymptomatic DM patients...
2015: Cardiovascular Ultrasound
Albert C Y Chan, Jeff W C Dai, Kenneth S H Chok, Tan To Cheung, Chung Mau Lo
BACKGROUND: Spontaneous tumor rupture (STR) is a life-threatening complication of hepatocellular carcinoma (HCC). Yet, interval partial hepatectomy (PH) is feasible in selected patients after hemostasis for the rupture event. Little is known, however, about the extent of negative prognostic impact STR had on these patients after resection. Our aim was to determine the impact of STR on the oncologic outcome of interval PH for ruptured HCC, and the prognostic value of STR on the current tumor node metastasis (TNM) classification...
February 2016: Surgery
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