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Red dot

Hao Wu, Fang Zeng, Hang Zhang, Jiangsheng Xu, Jianrong Qiu, Shuizhu Wu
The applications of photodynamic therapy (PDT) are usually limited by photosensitizers' side effects and singlet oxygen's short half-life. Herein, a mitochondria-targeted nanosystem is demonstrated to enhance the PDT efficacy by releasing a bio-precursor of photosensitizer under two-photon irradiation. A phototriggerable coumarin derivative is first synthesized by linking 5-aminolevulinic acid (5-ALA, the bio-precursor) to coumarin; and the nanosystem (CD-ALA-TPP) is then fabricated by covalently incorporating this coumarin derivative and a mitochondria-targeting compound triphenylphosphonium (TPP) onto carbon dots (CDs)...
February 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
S Topin-Ruiz, J-M Debarre, E Blanchard, S Kettani, P-J Valmier, L Martin, Y Le Corre
BACKGROUND: Circumscribed palmar hypokeratosis (CPH) is a rare skin disease, first described in 2002, associated with sudden localized reduction of the corneal layer. In most cases, it presents as an isolated rounded erythematous palmar lesion on the thenar eminence. We describe the dermoscopic semiology of CPH in 3 cases. PATIENTS AND METHODS: Three patients between the ages of 59 and 72 presented very limited erythematous lesions suggestive of CPH. Dermoscopic examination of these lesions provided similar findings...
October 19, 2016: Annales de Dermatologie et de Vénéréologie
Weidan Na, Qing Liu, Bowen Sui, Tianyu Hu, Xingguang Su
A novel and effective fluorescence strategy was developed for sensitive and selective detection of acid phosphatase (ACP). A förster resonance energy transfer (FRET) biosensor was established by attaching nile red (NR) to graphene quantum dots (GQDs) via lecithin/β-Cyclodextrin (lecithin/β-CD) complex as the linker. The introduction of lecithin/β-CD would brought GQDs-NR pair close enough through both electrostatic interaction and hydrophobic interaction, thereby making the FRET occur and thus resulting in the fluorescence quenching of GQDs (donor) and meanwhile the fluorescence enhancement of NR (acceptor)...
December 1, 2016: Talanta
Hamid Reza Samadikhah, Maryam Nikkhah, Saman Hosseinkhani
Two quantum dots (QDs), a green emitter, CdSe and a red emitter, CdSe with ZnS shell are encapsulated into novel liposomes in two different formulations including cationic liposomes. Quantum dots have proven themselves as powerful inorganic fluorescent probes, especially for long-term, multiplexed imaging and detection. Upon delivery into a cell, in endocytic vesicles such as endosomes, their fluorescence is quenched. We have investigated the potential toxic effects, photophysical properties and cell internalization of QDs in new formulation of liposomes as an in vitro vesicle model...
October 21, 2016: Luminescence: the Journal of Biological and Chemical Luminescence
Jung Yoon, Seung Gyu Yun, Jeeyong Kim, Yoo Na Jung, Young Eun Koh, Jeong Hun Nam, Eun Taek Han, Chae Seung Lim
We evaluated the diagnostic usefulness of the LH780 Coulter blood cell counter for detection and therapeutic monitoring of malaria including cross-reactivity with nucleated RBC (NRBC) samples. A total of 405 patients (43 patients with Plasmodium vivax malaria and the control group of 120 healthy subjects, 111 patients with fever, and 131 patients with NRBCs) were analyzed with routine CBC using the LH780. We analyzed the CBC results according to three selected parameters: an abnormal peak in the WBC histogram before 35fL, the presence of red dots in the nonwhite cell zone of 2D WBC Diff Dataplot, and platelet-related flags suggesting platelet clumps or giant platelets...
October 14, 2016: Acta Tropica
Hua-Jin Zeng, Min Miao, Zhe Liu, Ran Yang, Ling-Bo Qu
In this study, the fibrillation of hen egg-white lysozyme (HEWL) in the absence and presence of different amount of nitrogen-doped graphene quantum dots (N-GQDs) was studied by Thioflavin T (ThT) spectroscopy, Congo red (CR) binding assays, 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence assay, circular dichroism (CD) and transmission electron microscopy (TEM). The experimental results indicated that not only the fibrillation of HEWL at high temperature (65°C) and low pH (pH=2.0) could be inhibited effectively by N-GQDs, but the inhibition of HEWL by N-GQDs followed a dose-dependent manner...
October 13, 2016: International Journal of Biological Macromolecules
Andrea Albonico, Manuela Malaspina, Emanuela Bricolo, Marialuisa Martelli, Roberta Daini
Selective attention, i.e. the ability to concentrate one's limited processing resources on one aspect of the environment, is a multifaceted concept that includes different processes like spatial attention and its subcomponents of orienting and focusing. Several studies, indeed, have shown that visual tasks performance is positively influenced not only by attracting attention to the target location (orientation component), but also by the adjustment of the size of the attentional window according to task demands (focal component)...
October 12, 2016: Acta Psychologica
Huiren Peng, Yibin Jiang, Shuming Chen
Colloidal quantum dot light-emitting diodes (QLEDs) are recognized as promising candidates for next generation displays. QLEDs can be fabricated by low-cost solution processing except for the metal electrodes, which, in general, are deposited by costly vacuum evaporation. To be fully compatible with the low-cost solution process, we herein demonstrate vacuum-free and solvent-free fabrication of electrodes using a printable liquid metal. With eutectic gallium-indium (EGaIn) based liquid metal cathodes, vacuum-free-processed QLEDs are demonstrated with superior external quantum efficiencies of 11...
September 21, 2016: Nanoscale
Zhiqin Liang, Suling Zhao, Zheng Xu, Bo Qiao, Pengjie Song, Di Gao, Xurong Xu
We develop a colloidal synthesis of CsPbBr3 perovskite nanocrystals (NCs) at a relative low temperature (90 °C) for the bright blue emission which differs from the original green emission (~510 nm) of CsPbBr3 nanocubes as reported previously. Shapes of the obtained CsPbBr3 NCs can be systematically engineered into single and lamellar-structured 0D quantum dots, as well as face-to-face stacking 2D nanoplatelets and flat-lying 2D nanosheets via tuning the amounts of oleic acid (OA) and oleylamine (OM). They exhibit sharp excitonic PL emissions at 453 nm, 472 nm, 449 nm and 452 nm, respectively...
October 7, 2016: ACS Applied Materials & Interfaces
Yizhong Shen, Adam J Shuhendler, Deju Ye, Jing-Juan Xu, Hong-Yuan Chen
Two-photon excitation (TPE) nanoparticle-based photosensitizers (PSs) that combine the advantages of TPE and nanotechnology have emerged as attractive therapeutic agents for near-infrared red (NIR) light excited photodynamic therapy (PDT) for cancer treatment. TPE PDT is characterized by nonlinear absorption of two relatively low-energy photons of NIR light with the resulting emission of high-energy visible light. This high-energy light can sensitize oxygen to produce cytotoxic reactive oxygen species (ROS) and singlet oxygen ((1)O2) which can kill cancer cells...
October 5, 2016: Chemical Society Reviews
Venkatesh Gude, Ananya Das, Tanmay Chatterjee, Prasun K Mandal
The molecular origin of the photoluminescence of carbon dots (CDs) is not known. This restricts the design of CDs with desired optical properties. We have synthesized CDs starting from carbohydrates by employing a simple synthesis method. We were able to demonstrate that the CDs are composed of aggregated hydroxymethylfurfural (HMF) derivatives. The optical properties of these CDs are quite unique. These CDs exhibit an excitation-independent PL emission maximum in the orange-red region (λ ∼ 590 nm). These CDs also exhibit excitation as well as monitoring wavelength-independent single exponential PL decay...
October 12, 2016: Physical Chemistry Chemical Physics: PCCP
Chenhui Yang, Shoujun Zhu, Zhenglin Li, Zhuo Li, Chong Chen, Lei Sun, Wei Tang, Rui Liu, Ye Sun, Miao Yu
Nitrogen-doped carbon dots (CDs) have been produced by a new facile "bottom-up" synthesis, using the room-temperature reaction between acetonitrile and sodium-naphthalene. The obtained hydrophobic CDs are monodisperse (∼2.6 nm) and present an excitation-independent emission at ∼588 nm with a small full width at half-maximum (FWHM) of ∼52 nm. The CDs can be simply modified to be hydrosoluble and have been demonstrated to be an efficient red-emission agent for both in vivo and in vitro bioimaging.
September 29, 2016: Chemical Communications: Chem Comm
Richard J Alan Esteves, Shopan Hafiz, Denis O Demchenko, Ümit Özgür, Indika U Arachchige
Ge1-xSnx alloy quantum dots (QDs) were synthesized with sizes ranging from 1-3 nm exhibiting visible orange-red photoluminescence. Composition dependent optical properties were characterized and supported by theoretical calculations. Structural analysis suggests the QDs are diamond cubic phase, characteristic of Ge1-xSnx thin films and nanocrystals (NCs) reported to date.
September 22, 2016: Chemical Communications: Chem Comm
Jeongho Kim, Md Nafiujjaman, Md Nurunnabi, Yong-Kyu Lee, Hun-Kuk Park
Graphene quantum dots (GQDs) are potential candidates for various biomedical applications such as drug delivery, bioimaging, cell labeling, and biosensors. However, toxicological information on their effects on red blood cells (RBCs) and the mechanisms involved remain unexplored. To the best of our knowledge, our study is the first to investigate the toxicity effects of three GQDs with different surface functionalizations on the hemorheological characteristics of human RBCs, including hemolysis, deformability, aggregation, and morphological changes...
October 1, 2016: Food and Chemical Toxicology
Hyo-Min Kim, Di Geng, Jeonggi Kim, Eunsa Hwang, Jin Jang
We report highly efficient inverted QLED using Al doped ZnO (AZO)/Li doped ZnO (LZO) stack electron transport layer (ETL). An introduction of LZO layer on AZO improved the current and power efficiencies of the green (G-) QLED from 10.5 to 34.0 cd A-1 and from 5.4 to 29.6 lm W-1, respectively. The red (R-), G- and blue (B-) QLEDs fabricated in this work exhibited the maximum external quantum efficiencies (EQEs) of 8.4, 12.5 and 4.3 %, respectively. It is found from time-resolved photoluminescence (PL) and transient electroluminescence (EL) decay that exciton loss at the interface between ETL and emission layer can be significantly reduced by introducing LZO...
October 3, 2016: ACS Applied Materials & Interfaces
Haojun Jin, Yuqian Liu, Tianshu Xu, Xiaojun Qu, Feika Bian, Qingjiang Sun
By complexing a non-ionic G-quadruplex ligand with hybrid dual-emission quantum dots (QDs), a ratiometric fluorescent nanoprobe is developed for G-quadruplex detection in a sensitive and specific manner. The QDs nanohybrid comprised of a green-emission QD (gQD) and multiple red-emission QDs (rQDs) inside and outside of a silica shell, respectively, is utilized as the signal displaying unit. Only the presence of G-quadruplex can displace the ligand from QDs, breaking up the QDs-ligand complexation, and inducing the restoration of the rQDs fluorescence...
October 1, 2016: Analytical Chemistry
Jocelyn Qi Min Teo, Yiying Cai, Tze-Peng Lim, Thuan Tong Tan, Andrea Lay-Hoon Kwa
Singapore is an international travel and medical hub and faces a genuine threat for import and dissemination of bacteria with broad-spectrum resistance. In this review, we described the current landscape and management of carbapenem resistance in Gram-negative bacteria (GNB) in Singapore. Notably, the number of carbapenem-resistant Enterobacteriaceae has exponentially increased in the past two years. Resistance is largely mediated by a variety of mechanisms. Polymyxin resistance has also emerged. Interestingly, two Escherichia coli isolates with plasmid-mediated mcr-1 genes have been detected...
February 16, 2016: Microorganisms
Jung-Ho Jo, Jong-Hoon Kim, Ki-Heon Lee, Chang-Yeol Han, Eun-Pyo Jang, Young Rag Do, Heesun Yang
We report on the synthesis of highly fluorescent red-emitting InP quantum dots (QDs) and their application to the fabrication of a high-efficiency QD-light-emitting diode (QLED). The core/shell heterostructure of the QDs is elaborately tailored toward a multishelled structure with a composition-gradient ZnSeS intermediate shell and an outer ZnS shell. Using the resulting InP/ZnSeS/ZnS QDs as an emitting layer, all-solution-processible red InP QLEDs are fabricated with a hybrid multilayered device structure having an organic hole transport layer (HTL) and an inorganic ZnO nanoparticle electron transport layer...
September 1, 2016: Optics Letters
D Yu, B Levinthal, S L Franconeri
Perceiving the world around us requires that we resolve ambiguity. This process is often studied in the lab using ambiguous figures whose structures can be interpreted in multiple ways. One class of figures contains ambiguity in its depth relations, such that either of two surfaces could be seen as being the "front" of an object. Previous research suggests that selectively attending to a given location on such objects can bias the perception of that region as the front. This study asks whether selectively attending to a distributed feature can also bias that region toward the front...
September 7, 2016: Psychonomic Bulletin & Review
Wen-Ya Qiu, Li-Bin Zheng, Fei Pan, Bei-Bei Wang, Yu-Feng Yao
BACKGROUND: Reis-Bücklers corneal dystrophy (RBCD) was consistently reported as a corneal dystrophy only affected Bowman's layer and superficial corneal stroma, and superficial keratectomy was a recommendation surgery for treatment in literatures. The study reported new histopathological and ultrastructural findings in RBCD caused by the Arg124Leu mutation of transforming growth factor induced (TGFBI) gene in a four-generation Chinese pedigree. METHODS: Subjects including eight patients and seven unaffected family members received slit-lamp biomicroscopy and photography...
2016: BMC Ophthalmology
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