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https://www.readbyqxmd.com/read/28226799/an-audiovisual-bci-system-for-assisting-clinical-communication-assessment-in-patients-with-disorders-of-consciousness-a-case-study
#1
Fei Wang, Yanbin He, Jun Qu, Qiuyou Xie, Qing Lin, Xiaoxiao Ni, Yan Chen, Ronghao Yu, Chin-Teng Lin, Yuanqing Li, Fei Wang, Yanbin He, Jun Qu, Qiuyou Xie, Qing Lin, Xiaoxiao Ni, Yan Chen, Ronghao Yu, Chin-Teng Lin, Yuanqing Li, Chin-Teng Lin, Fei Wang, Ronghao Yu, Jun Qu, Yan Chen, Yanbin He, Qiuyou Xie, Yuanqing Li, Xiaoxiao Ni, Qing Lin
The JFK Coma Recovery Scale-Revised (JFK CRS-R), a behavioral scale, is often used for clinical assessments of patients with disorders of consciousness (DOC), such as patients in a vegetative state. However, there has been a high rate of clinical misdiagnosis with the JFK CRS-R because patients with severe brain injures cannot provide sufficient behavioral responses. It is particularly difficult to evaluate the communication function in DOC patients using the JFK CRS-R because a higher level of behavioral responses is needed for communication assessments than for many other assessments, such as an auditory startle assessment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222568/severe-disorders-of-consciousness-after-acquired-brain-injury-a-single-centre-long-term-follow-up-study
#2
Alex Lopez-Rolon
OBJECTIVES: To assess long-term clinical outcome, functional independence and health-related quality of life (HRQOL) in acquired brain injury (ABI) patients with a disorder of consciousness at admission to inpatient rehabilitation. METHODS: We selected patients from a cohort of ABI patients from a single centre. In addition to mortality, we measured level of consciousness with the Coma Remission Scale, functional independence with the Barthel Index, as well as generic and condition-specific HRQOL with the EQ5D and the "Quality of Life after Brain Injury" (QOLIBRI) respectively...
February 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28178070/prolonged-changes-in-amyloid-%C3%AE-metabolism-after-a-severe-traumatic-brain-injury
#3
Sergio Bagnato, Maria Andriolo, Cristina Boccagni, Giuseppe Galardi
Traumatic brain injury (TBI) is a major risk factor for Alzheimer's disease. Recent studies suggest that amyloid-beta (Aβ) deposit can be detected several years after TBI. However, it is unknown whether post-TBI Aβ deposits arise from short-term changes in Aβ metabolism or reflect a long-term sequela. To answer this question, we evaluated the cerebrospinal levels of Aβ several months after a severe TBI. The participants of this study were eight consecutive patients who developed a disorder of consciousness after a TBI, including seven in a minimally conscious state and one with unresponsive wakefulness syndrome (mean age: 35...
February 7, 2017: Neuroreport
https://www.readbyqxmd.com/read/28160751/pain-perception-in-patients-with-chronic-disorders-of-consciousness-what-can-limbic-system-tell-us
#4
Rocco Salvatore Calabrò, Antonino Naro, Alfredo Manuli, Antonino Leo, Rosaria De Luca, Viviana Lo Buono, Margherita Russo, Alessia Bramanti, Placido Bramanti
OBJECTIVE: Although it is believed that patients with Unresponsive Wakefulness Syndrome (UWS) do not feel pain, recent neuroimaging and neurophysiologic studies have demonstrated some residual traces of nociceptive processing. METHODS: To confirm this growing evidence, we evaluated 21 patients suffering from chronic disorders of consciousness (DOC) (both UWS, n=11, and Minimally Conscious State - MCS -, n=10), using an Event-Related Potential (ERP) Low-Resolution Brain Electromagnetic Tomography (LORETA) approach, based on nociceptive repeated laser stimulation (RLS)...
December 29, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28147246/spinal-cord-stimulation-modulates-frontal-delta-and-gamma-in-patients-of-minimally-consciousness-state
#5
Yang Bai, Xiaoyu Xia, Xiaoli Li, Yong Wang, Yi Yang, Yangfeng Liu, Zhenhu Liang, Jianghong He
Spinal cord stimulation (SCS) has been suggested as a therapeutic technique for treating patients with disorder of consciousness (DOC). Although studies have reported its benefits for patients, the underlying pathophysiological mechanisms remain unclear. The aim of this study was to measure the effects of SCS on the EEG of patients in a minimally conscious state (MCS), which would allow us to explore the possible workings underpinning of the approach. Resting state EEG was recorded before and immediately after SCS, using various frequencies (5Hz, 20Hz, 50Hz, 70Hz and 100Hz), for 11 patients in MCS...
January 29, 2017: Neuroscience
https://www.readbyqxmd.com/read/28120050/spinal-cord-stimulation-for-vegetative-state-and-minimally-conscious-state-changes-in-consciousness-level-and-motor-function
#6
Takamitsu Yamamoto, Mitsuru Watanabe, Toshiki Obuchi, Kazutaka Kobayashi, Hideki Oshima, Chikashi Fukaya, Atsuo Yoshino
Twenty-one vegetative state (VS) patients and 10 minimally conscious state (MCS) patients were treated by spinal cord stimulation (SCS) following an electrophysiological evaluation 3 months or more after the onset of brain injury.A flexible four-contact cylindrical electrode was inserted into the epidural space of the cervical vertebrae, and placed at cervical levels C2-C4. Five-hertz stimulation was applied for 5 min every 30 min during the daytime at an intensity that produced muscle twitches of the upper extremities...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28120048/recovery-from-chronic-diseases-of-consciousness-state-of-the-art-in-neuromodulation-for-persistent-vegetative-state-and-minimally-conscious-state
#7
Pier Paolo Mattogno, Giuseppe Barbagallo, Gerardo Iacopino, Gaetano Pappalardo, Giuseppe LA Rocca, Francesco Signorelli, Jun Zhong, Massimiliano Visocchi
Chronic diseases of consciousness (CDC) can still be considered a challenging frontier for modern medicine, probably because of their not completely understood physiopathological mechanisms. Following encouraging evidence on cerebral hemodynamics, some authors have hypothesized a role for neuromodulation in the treatment of CDC patients. In the past 40 years, spinal cord stimulation (SCS) and deep brain stimulation (DBS) have been used experimentally for the treatment of patients in a severe altered state of consciousness, with some interesting but not conclusive results...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28113255/testing-the-significance-of-connectivity-networks-comparison-of-different-assessing-procedures
#8
Jlenia Toppi, Donatella Mattia, Monica Risetti, Rita Formisano, Fabio Babiloni, Laura Astolfi
: Despite the well-established use of partial directed coherence (PDC) to estimate interactions between brain signals, the assessment of its statistical significance still remains controversial. Commonly used approaches are based on the generation of empirical distributions of the null case, implying a considerable computational time, which may become a serious limitation in practical applications. Recently, rigorous asymptotic distributions for PDC were proposed. The aim of this work is to compare the performances of the asymptotic statistics with those of an empirical approach, in terms of both accuracy and computational time...
October 26, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28102097/familiar-auditory-sensory-training-in-chronic-traumatic-brain-injury-a-case-study
#9
Emily Galassi Sullivan, Ann Guernon, Brett Blabas, Amy A Herrold, Theresa L-B Pape
PURPOSE: The evaluation and treatment for patients with prolonged periods of seriously impaired consciousness following traumatic brain injury (TBI), such as a vegetative or minimally conscious state, poses considerable challenges, particularly in the chronic phases of recovery. METHOD: This blinded crossover study explored the effects of familiar auditory sensory training (FAST) compared with a sham stimulation in a patient seven years post severe TBI. Baseline data were collected over 4 weeks to account for variability in status with neurobehavioral measures, including the Disorders of Consciousness scale (DOCS), Coma Near Coma scale (CNC), and Consciousness Screening Algorithm...
January 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28093373/improved-arousal-and-motor-function-using-zolpidem-in-a-patient-with-space-occupying-intracranial-lesions-a-case-report
#10
Martin Nicholas Bomalaski, Sean Robinson Smith
: Patients with disorders of consciousness (DOC) have profound functional limitations with few treatment options for improving arousal and quality of life. Zolpidem is a nonbenzodiazepine hypnotic used to treat insomnia that has also been observed to paradoxically improve arousal in those with DOC, such as the vegetative or minimally conscious states. Little information exists on its use in patients with DOC who have intracranial space-occupying lesions. We present a case of a 24-year-old man in a minimally conscious states due to central nervous system lymphoma who was observed to have increased arousal and improved motor function after the administration of zolpidem...
January 16, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28059800/twist-and-turn-into-chronic-disorders-of%C3%A2-consciousness-potential-role-of%C3%A2-the%C3%A2-auditory-stapedial-reflex
#11
Antonino Naro, Rocco Bruno, Antonino Leo, Margherita Russo, Carlo Salviera, Alessia Bramanti, Placido Bramanti, Rocco Salvatore Calabrò
BACKGROUND: Patients suffering from chronic disorders of consciousness (DOC), including minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS), typically show an awareness impairment paralleled by a significant reflex hyper-excitability, which depend on the cortical deafferentation following brain-damage-induced thalamocortical system deterioration. Nonetheless, recent studies have shown a residual preservation of cortico-subcortical pathways that may sustain residual fragments of awareness in some DOC patients...
January 3, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28041983/basic-discriminative-and-semantic-processing-in-patients-in-the-vegetative-and-minimally-conscious-state
#12
Helena Erlbeck, Ruben G L Real, Boris Kotchoubey, Donatella Mattia, Jakob Bargak, Andrea Kübler
Patients who survive injuries to the brain following accidents or diseases often acquire a disorder of consciousness (DOC). Assessment of the state of consciousness in these patients is difficult since they are usually incapable of reproducible motor movements. The application of event-related potentials (ERP) recorded via EEG constitutes one promising approach to complement the assessment of cognitive functions in DOC patients. For these assessments, a hierarchical approach was suggested which means that paradigms aiming at higher order ERPs are only presented if early responses were found...
December 30, 2016: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28009244/neuroethics-and-disorders-of-consciousness-discerning-brain-states-in-clinical-practice-and-research
#13
Joseph J Fins
Decisions about end-of-life care and participation in clinical research for patients with disorders of consciousness begin with diagnostic discernment. Accurately distinguishing between brain states clarifies clinicians' ethical obligations and responsibilities. Central to this effort is the obligation to provide neuropalliative care for patients in the minimally conscious state who can perceive pain and to restore functional communication through neuroprosthetics, drugs, and rehabilitation to patients with intact but underactivated neural networks...
December 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28007989/cad-mutations-and-uridine-responsive-epileptic-encephalopathy
#14
Johannes Koch, Johannes A Mayr, Bader Alhaddad, Christian Rauscher, Jörgen Bierau, Reka Kovacs-Nagy, Karlien L M Coene, Ingrid Bader, Monika Holzhacker, Holger Prokisch, Hanka Venselaar, Ron A Wevers, Felix Distelmaier, Tilman Polster, Steffen Leiz, Cornelia Betzler, Tim M Strom, Wolfgang Sperl, Thomas Meitinger, Saskia B Wortmann, Tobias B Haack
Unexplained global developmental delay and epilepsy in childhood pose a major socioeconomic burden. Progress in defining the molecular bases does not often translate into effective treatment. Notable exceptions include certain inborn errors of metabolism amenable to dietary intervention. CAD encodes a multifunctional enzyme involved in de novo pyrimidine biosynthesis. Alternatively, pyrimidines can be recycled from uridine. Exome sequencing in three families identified biallelic CAD mutations in four children with global developmental delay, epileptic encephalopathy, and anaemia with anisopoikilocytosis...
December 21, 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28007704/police-officer-in-minimally-conscious-state-should-be-allowed-to-die-says-judge
#15
Clare Dyer
No abstract text is available yet for this article.
December 22, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27986800/a-matter-of-life-and-death-controversy-at-the-interface-between-clinical-and-legal-decision-making-in-prolonged-disorders-of-consciousness
#16
Lynne Turner-Stokes
Best interests decision-making and end-of-life care for patients in permanent vegetative or minimally conscious states (VS/MCS) is a complex area of clinical and legal practice, which is poorly understood by most clinicians, lawyers and members of the public. In recent weeks, the Oxford Shrieval lecture by Mr Justice Baker ('A Matter of Life and Death', 11 October 2016) and its subsequent reporting in the public press has sparked debate on the respective roles of clinicians, the Court of Protection and the Mental Capacity Act 2005 in decisions to withhold or withdraw life-sustaining treatments from patients with disorders of consciousness...
December 16, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27973398/microbiological-quality-of-fresh-nopal-juice
#17
Ana María Hernández-Anguiano, Patricia Landa-Salgado, Carlos Alberto Eslava-Campos, Mateo Vargas-Hernández, Jitendra Patel
The consumption of fresh nopal cactus juice is widely popular among health-conscious consumers in Mexico. The juice is prepared from fresh cladodes that have only been rinsed with tap water and are not subjected to a pasteurization or terminal bacterial reduction process. The aim of this study was to evaluate the microbial quality of commercially available fresh juices (n = 162) made with nopal in Texcoco, State of Mexico, during the summer and spring season. Standard microbiological methods, the PCR technique and the serological method were used for isolation and identification of bacteria...
December 10, 2016: Microorganisms
https://www.readbyqxmd.com/read/27958328/distinct-interactions-between-fronto-parietal-and-default-mode-networks-in-impaired-consciousness
#18
Jinyi Long, Qiuyou Xie, Qing Ma, M A Urbin, Liqing Liu, Ling Weng, Xiaoqi Huang, Ronghao Yu, Yuanqing Li, Ruiwang Huang
Existing evidence suggests that the default-mode network (DMN) and fronto-pariatal network (FPN) play an important role in altered states of consciousness. However, the brain mechanisms underlying impaired consciousness and the specific network interactions involved are not well understood. We studied the topological properties of brain functional networks using resting-state functional MRI data acquired from 18 patients (11 vegetative state/unresponsive wakefulness syndrome, VS/UWS, and 7 minimally conscious state, MCS) and compared these properties with those of healthy controls...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27936939/a-study-of-the-internal-construct-and-predictive-validity-of-the-smart-assessment-for-emergence-from-vegetative-state
#19
A Tennant, H Gill-Thwaites
OBJECTIVE: The Sensory Modality Assessment and Rehabilitation Technique (SMART) was developed to assess the levels of awareness, functional, sensory and communicative abilities of adults in vegetative (VS) or minimally-conscious states following severe brain injury. The current study seeks to ascertain if a total score can be derived from the individual assessments contained within SMART and to test the internal construct and predictive validity of that total score. SUBJECTS: Persons in VS were recruited over a 3-year period and current status was determined after a 17-year follow-up...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27930506/change-of-ascending-reticular-activating-system-with-recovery-from-vegetative-state-to-minimally-conscious-state-in-a-stroke-patient
#20
Sung Ho Jang, Chul Hoon Chang, Young Jin Jung, You Sung Seo
RATIONALE: We report on a stroke patient who showed change of the ascending reticular activating system (ARAS) concurrent with recovery from a vegetative state (VS) to a minimally conscious state (MCS), which was demonstrated on diffusion tensor tractography (DTT). PATIENT CONCERNS: A 59-year-old male patient underwent CT-guided stereotactic drainage 3 times for management of intracerebral hemorrhage and intraventricular hemorrhage. DIAGNOSIS: After 4 months from onset, when starting rehabilitation, the patient showed impaired consciousness, with a Glasgow Coma Scale (GCS) score of 6 and a Coma Recovery Scale-Revised score of 2...
December 2016: Medicine (Baltimore)
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