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diphenhydramine anesthetic

Sophie Gosselin, Lotte C G Hoegberg, Robert S Hoffman, Andis Graudins, Christine M Stork, Simon H L Thomas, Samuel J Stellpflug, Bryan D Hayes, Michael Levine, Martin Morris, Andrea Nesbitt-Miller, Alexis F Turgeon, Benoit Bailey, Diane P Calello, Ryan Chuang, Theodore C Bania, Bruno Mégarbane, Ashish Bhalla, Valéry Lavergne
BACKGROUND: Although intravenous lipid emulsion (ILE) was first used to treat life-threatening local anesthetic (LA) toxicity, its use has expanded to include both non-local anesthetic (non-LA) poisoning and less severe manifestations of toxicity. A collaborative workgroup appraised the literature and provides evidence-based recommendations for the use of ILE in poisoning. METHODS: Following a systematic review of the literature, data were summarized in four publications: LA and non-LA poisoning efficacy, adverse effects, and analytical interferences...
September 8, 2016: Clinical Toxicology
Eric C Wilkerson, W Elliot Love
No abstract text is available yet for this article.
February 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama
In order to bridge the gap of action of dl-sotalol between the human ether-a-go-go-related gene (hERG) K(+) channel inhibition in vitro and QT-interval prolongation in vivo, its electropharmacological effect and pharmacokinetic property were simultaneously studied in comparison with those of 10 drugs having potential to prolong the QT interval (positive drugs: bepridil, haloperidol, dl-sotalol, terfenadine, thioridazine, moxifloxacin, pimozide, sparfloxacin, diphenhydramine, imipramine and ketoconazole) and four drugs lacking such property (negative drugs: enalapril, phenytoin, propranolol or verapamil) with the halothane-anesthetized guinea pig model...
April 2016: Cardiovascular Toxicology
Mofei Wang, Toshishige Shibamoto, Mamoru Tanida, Yuhichi Kuda, Yasutaka Kurata
AIMS: Systemic anaphylaxis is life-threatening, and its pathophysiology is not fully clarified. Mice are frequently used for experimental study on anaphylaxis. However, the hemodynamic features and mechanisms of mouse anaphylactic hypotension remain unknown. Therefore, we determined mechanisms of systemic and pulmonary vascular response to anaphylactic hypotension in anesthetized BALB/c mice by using receptor antagonists of chemical mediators. MAIN METHODS: Anaphylaxis was actively induced by an intravenous injection of the ovalbumin antigen into open-chest artificially ventilated sensitized mice...
October 29, 2014: Life Sciences
Mamoru Tanida, Katsuya Nagai
Autonomic nerves, consisting of both sympathetic and parasympathetic nerves, regulate various bodily functions such as blood pressure, body temperature, glucose metabolism, energy metabolism, and digestion. Our studies in rats and mice have demonstrated that food, flavor, and music affect physiological phenomena via changes in autonomic neurotransmissions. Intestinal injection of Lactobacillus johnsonii La1 (NCC533) suppressed sympathetic nerves that innervate the adrenal gland and kidney of urethane-anesthetized rats, lowering blood glucose and blood pressure levels, and excited the gastric parasympathetic nerve, elevating appetite and body weight...
2011: Bioscience and Microflora
Takuo Fujita, Mutsumi Ohue, Yoshio Fujii, Tsuyoshi Jotoku, Akimitsu Miyauchi, Yasuyuki Takagi, Masahiro Tsuchiya, Yasuo Endo
Pain is sensed, transmitted, and modified via a variety of mediators and their receptors. Histamine is a well-known mediator of pain. In addition to their antagonistic effects against histamine, classical antihistaminics possess, to various degrees, antimuscarinergic, antiserotonergic, antiadrenergic, local anesthetic, membrane-stabilizing and other pharmacologic actions. Although there have been many attempts to use classical antihistaminics as analgesics and/or analgesic adjuvants, the appearance of non-steroidal anti-inflammatory drugs discouraged such efforts...
2013: Pharmacology
Yu-Wen Chen, Jann-Inn Tzeng, Ting-Yun Chen, Jhi-Joung Wang, Yu-Chung Chen, Ching-Hsia Hung
Although diphenhydramine has been shown to produce longer duration of spinal block than lidocaine, few studies disclose its skin infiltrative anesthesia when compared with a long-lasting local anesthetic, bupivacaine. The purpose of this study was to investigate whether diphenhydramine elicited cutaneous analgesia in comparison with bupivacaine. After inhibition of cutaneous trunci muscle reflex via subcutaneous injection of drugs in rats, we examined the local anesthetic effect of diphenhydramine and bupivacaine as infiltrative cutaneous analgesia in a dose-dependent fashion...
August 2014: Fundamental & Clinical Pharmacology
David C Sheridan, David M Spiro, Thuan Nguyen, Thomas K Koch, Garth D Meckler
OBJECTIVE: Limited progress has been made in the past decade for abortive treatment of migraine headache in the pediatric emergency department (PED). Propofol, a general anesthetic, has been reported to be effective in the treatment of refractory headaches in adults at subanesthetic doses but never in the pediatric population. The goal of this study was to review our institution's experience with subanesthetic doses of propofol for the abortive treatment of pediatric migraine and compare propofol with standard abortive therapy in the PED...
December 2012: Pediatric Emergency Care
Akira Takahara, Kaori Fujiwara, Atsushi Ohtsuki, Takayuki Oka, Iyuki Namekata, Hikaru Tanaka
Cloperastine is an antitussive drug, which can be received as an over-the-counter cold medicine. The chemical structure of cloperastine is quite similar to that of the antihistamine drug diphenhydramine, which is reported to inhibit hERG K⁺ channels and clinically induce long QT syndrome after overdose. To analyze its proarrhythmic potential, we compared effects of cloperastine and diphenhydramine on the hERG K⁺ channels expressed in HEK293 cells. We further assessed their effects on the halothane-anesthetized guinea-pig heart under the monitoring of monophasic action potential (MAP) of the ventricle...
2012: Journal of Pharmacological Sciences
Zhenxiong Zhang, Cancan Zhang, Moxi Zhou, Fadi Xu
Rapid shallow breathing (RSB) is mainly mediated by bronchopulmonary C-fibers (PCFs). We asked whether this RSB could be modulated by opioids. In anesthetized rats right atrial bolus injection of phenylbiguanide (PBG) to evoke RSB was repeated after: (1) intravenously giving fentanyl (μ-receptor agonist), DPDPE (δ-receptor agonist), or U-50488H (κ-receptor agonist); (2) fentanyl (iv) following naloxone methiodide, a peripheral opioid receptor antagonist; (3) bilateral microinjection of fentanyl into the nodose ganglia; (4) fentanyl (iv) with pre-blocking histamine H(1) and H(2) receptors by diphenhydramine and ranitidine...
September 30, 2012: Respiratory Physiology & Neurobiology
Anthony F Alario, Christopher G Pirie, Stefano Pizzirani
PURPOSE:  To describe anterior segment fluorescein angiography (ASFA) of the normal canine eye using two different sedation/anesthetic protocols and a digital single lens-reflex (dSLR) camera adaptor. METHODS: Dogs free of ocular and systemic disease were used for this study. Dogs received maropitant citrate (1.0 mg/kg SQ) and diphenhydramine (2.0mg/kg SQ) 20min prior to butorphanol [n = 6] (0.2 mg/kg IV) or propofol [n=6] (4 mg/kg IV bolus, 0.2 mg/kg/min CRI)...
January 2013: Veterinary Ophthalmology
Ching-Hsia Hung, Chin-Chen Chu, Yu-Chung Chen, Yu-Wen Chen, Zong-Ying Li, Jhi-Joung Wang
The aim of this study was to evaluate the local anesthetic effects of pheniramine and diphenhydramine, two histamine H₁ receptor antagonists, on spinal anesthesia and their comparison with lidocaine, a commonly used local anesthetic. After rats were injected intrathecally with diphenhydramine and pheniramine, the dose-response curves were obtained. The potency and duration of diphenhydramine and pheniramine on spinal anesthesia were compared with lidocaine. We showed that diphenhydramine and pheniramine produced dose-dependent spinal blockades in motor function, proprioception, and nociception...
December 30, 2011: European Journal of Pharmacology
David E Cochrane, Robert E Carraway, Kimberly Harrington, Melissa Laudano, Stephen Rawlings, Ross S Feldberg
OBJECTIVE AND DESIGN: To determine if mast cells synthesize the inflammatory peptide, neurotensin (NT), secrete immunoreactive and bioactive NT, and express the NT receptor NTS1. MATERIALS: HMC-1 cells, pleural mast cells from Sprague-Dawley rats, LAD2 mast cells, and human cord blood mast cells were used. TREATMENT: HMC-1 cells were stimulated with NT, C48/80, mastoparan, or PGE(2). For changes in cutaneous vascular permeability, anesthetized rats were injected intravenously with Evans Blue dye and intradermally with saline, NT, histamine, diphenhydramine, and C48/80...
December 2011: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Steven F Rodgers, Matthew S Rodgers
PURPOSE: This follow-up study provides an additional 7 years of data (December 2001 through November 2008) pertaining to complications that occurred in patients who received intravenous sedation in the practice of a single board-certified oral and maxillofacial surgeon. Together with the previously published 7 years of data (December 1994 through November 2001), this study summarizes the frequency of various complications encountered in patients sedated intravenously by the surgeon over a 14-year period...
October 2011: Journal of Oral and Maxillofacial Surgery
Kristen L Ochs, Michele Zell-Kanter, Mark B Mycyk
The elderly are particularly sensitive to delirium-inducing medications. We report a case of a 93-year-old woman who developed anticholinergic delirium from subcutaneous diphenhydramine that she received in the emergency department. This patient was reportedly allergic to “caine” anesthetic agents, and thus, subcutaneous diphenhydramine was administered as an alternative local anesthetic, as recommended in emergency medicine textbooks. Within 20 minutes of administration, the patient developed agitation, tachycardia, dilated pupils, and dry skin, consistent with a classic anticholinergic toxidrome...
March 2012: American Journal of Emergency Medicine
Peter G Pavlidakey, Erin E Brodell, Stephen E Helms
Patients who present with a history of "allergy" to local anesthetics are common in clinical practice. Injectable 1% diphenhydramine is a safe, inexpensive, and effective local anesthetic for simple dermatological procedures in patients who report "caine" allergies. Utilizing this agent permits the dermatologist to operate at the time of the initial visit and schedule a referral to the allergist for definitive sensitivity testing at the patient's convenience.
October 2009: Journal of Clinical and Aesthetic Dermatology
Claudia Maria Nogueira Correa, Gisele Zapata Sudo, Roberto Takashi Sudo
BACKGROUND AND OBJECTIVES: Since atracurium can cause hypotension in humans, the hemodynamic effects of atracurium and cisatracurium as well as the hemodynamic protection of diphenhydramine and cimetidine were investigated in rats. METHODS: 1) Wistar rats were anesthetized with sodium pentobarbital and prepared according to Brown et al. to evaluate different doses of atracurium and cisatracurium in the reduction of T4/T1 equal or greater than 95%. 2) Assessment of the hemodynamic changes caused by the intravenous administration of atracurium and cisatracurium by monitoring the blood pressure in the carotid artery and the electrocardiogram of rats...
January 2010: Revista Brasileira de Anestesiologia
(no author information available yet)
No abstract text is available yet for this article.
September 2009: Consumer Reports
M Tanida, J Shen, D Kubomura, K Nagai
Previous studies have demonstrated that central injection of L-carnosine (beta-alynyl-L-histidine), dipeptide synthesized in mammalian muscles, affects renal sympathetic nerve activity (RSNA) and blood pressure (BP) in anesthetized rats. In the present study, using urethane-anesthetized rats, we examined the dose-dependent effects of intravenous (IV) injection of various doses of anserine, dipeptide of similar structure to L-carnosine, on RSNA, BP and heart rate (HR). We found that injection of a low dose of anserine (1 microg) significantly suppressed RSNA, BP and HR...
2010: Physiological Research
Phillip J Suffridge, Michael N Wiggins, Reid D Landes, Richard A Harper
OBJECTIVE: To determine whether 5% diphenhydramine solution has an anesthetic effect when administered topically to rabbit corneas. DESIGN: Experimental study. PARTICIPANTS: Twenty white New Zealand rabbits. METHODS: Twenty rabbits at the University of Arkansas for Medical Sciences received 1 drop of 5% diphenhydramine solution in the left eye and 1 drop of balanced salt solution in the right eye. Corneal sensation was then measured with a Cochet-Bonnet esthesiometer at 30-, 60-, and 90-minute intervals...
April 2009: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
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