Shiva Razavi, Felix Wong, Bedri Abubaker-Sharif, Hideaki T Matsubayashi, Hideki Nakamura, Eduardo Sandoval, Douglas N Robinson, Baoyu Chen, Jian Liu, Pablo A Iglesias, Takanari Inoue
Non-linear biomolecular interactions on the membranes drive membrane remodeling that underlies fundamental biological processes including chemotaxis, cytokinesis, and endocytosis. The multitude of biomolecules, the redundancy in their interactions, and the importance of spatiotemporal context in membrane organization hampers understanding the physical principles governing membrane mechanics. A minimal, in vitro system that models the functional interactions between molecular signaling and membrane remodeling, while remaining faithful to cellular physiology and geometry is powerful yet remains unachieved...
September 23, 2023: bioRxiv