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https://www.readbyqxmd.com/read/29764801/assessing-unmet-information-needs-of-breast-cancer-survivors-exploratory-study-of-online-health-forums-using-text-classification-and-retrieval
#1
Susan McRoy, Majid Rastegar-Mojarad, Yanshan Wang, Kathryn J Ruddy, Tufia C Haddad, Hongfang Liu
BACKGROUND: Patient education materials given to breast cancer survivors may not be a good fit for their information needs. Needs may change over time, be forgotten, or be misreported, for a variety of reasons. An automated content analysis of survivors' postings to online health forums can identify expressed information needs over a span of time and be repeated regularly at low cost. Identifying these unmet needs can guide improvements to existing education materials and the creation of new resources...
May 15, 2018: JMIR Cancer
https://www.readbyqxmd.com/read/29764690/inter-ray-variation-in-metatarsal-strength-properties-in-humans-and-african-apes-implications-for-inferring-bipedal-biomechanics-in-the-olduvai-hominid-8-foot
#2
Biren A Patel, Tea Jashashvili, Stephanie H Bui, Kristian J Carlson, Nicole L Griffin, Ian J Wallace, Caley M Orr, Randall L Susman
When measured as a ratio of mean midshaft diameter to bone length, the OH 8 fossil hominin foot exhibits a metatarsal (Mt) robusticity pattern of 1 > 5 > 3 > 4 > 2, which differs from the widely perceived "common" modern human pattern (1 > 5 > 4 > 3 > 2); African apes generally exhibit a third pattern (1 > 2 > 3 > 4 > 5). Largely because of the relative ranking of Mt2 and Mt5, OH 8 metatarsals structurally resemble the pattern exhibited by bipedal humans more than the pattern of quadrupedal and climbing African apes...
May 12, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29763967/machine-learning-algorithms-for-outcome-prediction-in-chemo-radiotherapy-an-empirical-comparison-of-classifiers
#3
Timo M Deist, Frank J W M Dankers, Gilmer Valdes, Robin Wijsman, I-Chow Hsu, Cary Oberije, Tim Lustberg, Johan van Soest, Frank Hoebers, Arthur Jochems, Issam El Naqa, Leonard Wee, Olivier Morin, David R Raleigh, Wouter Bots, Johannes H Kaanders, José Belderbos, Margriet Kwint, Timothy Solberg, René Monshouwer, Johan Bussink, Andre Dekker, Philippe Lambin
PURPOSE: Machine learning classification algorithms (classifiers) for prediction of treatment response are becoming more popular in radiotherapy literature. General machine learning literature provides evidence in favor of some classifier families (random forest, support vector machine, gradient boosting) in terms of classification performance. The purpose of this study is to compare such classifiers specifically for (chemo)radiotherapy datasets and to estimate their average discriminative performance for radiation treatment outcome prediction...
May 15, 2018: Medical Physics
https://www.readbyqxmd.com/read/29763705/detecting-pathway-biomarkers-of-diabetic-progression-with-differential-entropy
#4
Zhi-Ping Liu, Rui Gao
Gene expression profiling techniques measure the transcriptional dynamics of thousands of genes in parallel manners. The available high-throughput transcriptomic datasets provide unprecedented opportunities of detecting biomarkers or signatures of complex diseases such as diabetes. In this work, we propose a computational method based on differential entropy to identify diabetic pathway biomarkers in rats from gene expression profiling data. We first collect the knowledgebase-documented pathways and map them with the corresponding gene expressions in control and disease samples, respectively...
May 12, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29733474/computed-tomographic-description-of-the-highly-variable-imaging-features-of-equine-oromaxillary-sinus-and-oronasal-fistulae
#5
Laura Hargreaves, Jonathon J Dixon
Oronasal and oromaxillary sinus fistulae are well-documented complications following removal or loss of a maxillary cheek tooth. Diagnosis is currently based on a combination of oral examination, videoendoscopy, radiography, and computed tomography (CT). The objective of this retrospective, case series study was to describe the CT characteristics of confirmed oronasal and oromaxillary sinus fistulae in a group of horses. Inclusion criteria were a head CT acquired at the authors' hospital during the period of 2012-2017, a CT diagnosis of oronasal or oromaxillary sinus fistulae, and a confirmed diagnosis based on a method other than CT...
May 7, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29729655/adolescent-girls-experiences-with-sexual-pressure-coercion-and-victimization-metoo
#6
Dianne Morrison-Beedy, Linsey Grove
BACKGROUND: The #MeToo social media campaign in the United States has highlighted what is a pervasive problem in many cultures-the sexual intimidation and victimization of women by men, especially those in roles of authority. METHODS: In a study of 735 girls, ages 15-19 years, enrolled in a sexual risk reduction randomized controlled trial, we captured baseline data using audio-computer assisted self-interviews to increase validity and reliability of responses to questions regarding such behaviors...
May 5, 2018: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/29718132/imagepy-an-open-source-python-based-and-platform-independent-software-package-for-boimage-analysis
#7
Anliang Wang, Xiaolong Yan, Zhijun Wei
Summary: This note presents the design of a scalable software package named ImagePy for analysing biological images. Our contribution is concentrated on facilitating extensibility and interoperability of the software through decoupling the data model from the user interface. Especially with assistance from the Python ecosystem, this software framework makes modern computer algorithms easier to be applied in bioimage analysis. Availability: ImagePy is free and open source software, with documentation and code available at https://github...
April 27, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29707196/improving-communication-for-interdisciplinary-teams-working-on-storage-of-digital-information-in-dna
#8
Emily E Hesketh, Jossy Sayir, Nick Goldman
Close collaboration between specialists from diverse backgrounds and working in different scientific domains is an effective strategy to overcome challenges in areas that interface between biology, chemistry, physics and engineering. Communication in such collaborations can itself be challenging.  Even when projects are successfully concluded, resulting publications - necessarily multi-authored - have the potential to be disjointed. Few, both in the field and outside, may be able to fully understand the work as a whole...
2018: F1000Research
https://www.readbyqxmd.com/read/29705925/knees-acl-has-superior-responsiveness-compared-to-the-most-commonly-used-patient-reported-outcome-measures-for-anterior-cruciate-ligament-injury
#9
Jonathan David Comins, Volkert Dirk Siersma, Martin Lind, Bent Wulff Jakobsen, Michael Rindom Krogsgaard
PURPOSE: For clinical trials, it is essential that measures are sensitive to change. The aim of this study was to conduct a head-to-head comparison of responsiveness of four PROMs used to measure outcome after anterior cruciate ligament (ACL) reconstruction. The PROMs compared were the knee injury osteoarthritis outcome score (KOOS), the international knee documentation committee subjective form (IKDC), the Lysholm score, and the knee numeric-entity evaluation score (KNEES-ACL). We hypothesized that KNEES-ACL would be more responsive than the other PROMs, as KNEES-ACL was created based on patient interviews and validated using Rasch analysis...
April 28, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29704868/inter-laboratory-comparison-of-channelized-hotelling-observer-computation
#10
Alexandre Ba, Craig Abbey, Jongduk Baek, Minah Han, Ramona W Bouwman, Christiana Balta, Jovan Brankov, Francesc Massanes, Howard C Gifford, Irene Hernandez-Giron, Wouter J H Veldkamp, Dimitar Petrov, Nicholas Marshall, Frank W Samuelson, Rongping Zeng, Justin B Solomon, Ehsan Samei, Pontus Timberg, Hannie Förnvik, Ingrid Reiser, Lifeng Yu, Hao Gong, François O Bochud
PURPOSE: The task-based assessment of image quality using model observers is increasingly used for the assessment of different imaging modalities. However, the performance computation of model observers needs standardization as well as a well-established trust in its implementation methodology and uncertainty estimation. The purpose of this work was to determine the degree of equivalence of the channelized Hotelling observer performance and uncertainty estimation using an intercomparison exercise...
April 28, 2018: Medical Physics
https://www.readbyqxmd.com/read/29701723/integrated-chemometrics-and-statistics-to-drive-successful-proteomics-biomarker-discovery
#11
REVIEW
Anouk Suppers, Alain J van Gool, Hans J C T Wessels
Protein biomarkers are of great benefit for clinical research and applications, as they are powerful means for diagnosing, monitoring and treatment prediction of different diseases. Even though numerous biomarkers have been reported, the translation to clinical practice is still limited. This mainly due to: (i) incorrect biomarker selection, (ii) insufficient validation of potential biomarkers, and (iii) insufficient clinical use. In this review, we focus on the biomarker selection process and critically discuss the chemometrical and statistical decisions made in proteomics biomarker discovery to increase to selection of high value biomarkers...
April 26, 2018: Proteomes
https://www.readbyqxmd.com/read/29678766/in-silico-toxicology-protocols
#12
Glenn J Myatt, Ernst Ahlberg, Yumi Akahori, David Allen, Alexander Amberg, Lennart T Anger, Aynur Aptula, Scott Auerbach, Lisa Beilke, Phillip Bellion, Romualdo Benigni, Joel Bercu, Ewan D Booth, Dave Bower, Alessandro Brigo, Natalie Burden, Zoryana Cammerer, Mark T D Cronin, Kevin P Cross, Laura Custer, Magdalena Dettwiler, Krista Dobo, Kevin A Ford, Marie C Fortin, Samantha E Gad-McDonald, Nichola Gellatly, Véronique Gervais, Kyle P Glover, Susanne Glowienke, Jacky Van Gompel, Steve Gutsell, Barry Hardy, James S Harvey, Jedd Hillegass, Masamitsu Honma, Jui-Hua Hsieh, Chia-Wen Hsu, Kathy Hughes, Candice Johnson, Robert Jolly, David Jones, Ray Kemper, Michelle O Kenyon, Marlene T Kim, Naomi L Kruhlak, Sunil A Kulkarni, Klaus Kümmerer, Penny Leavitt, Bernhard Majer, Scott Masten, Scott Miller, Janet Moser, Moiz Mumtaz, Wolfgang Muster, Louise Neilson, Tudor I Oprea, Grace Patlewicz, Alexandre Paulino, Elena Lo Piparo, Mark Powley, Donald P Quigley, M Vijayaraj Reddy, Andrea-Nicole Richarz, Patricia Ruiz, Benoit Schilter, Rositsa Serafimova, Wendy Simpson, Lidiya Stavitskaya, Reinhard Stidl, Diana Suarez-Rodriguez, David T Szabo, Andrew Teasdale, Alejandra Trejo-Martin, Jean-Pierre Valentin, Anna Vuorinen, Brian A Wall, Pete Watts, Angela T White, Joerg Wichard, Kristine L Witt, Adam Woolley, David Woolley, Craig Zwickl, Catrin Hasselgren
The present publication surveys several applications of in silico (i.e., computational) toxicology approaches across different industries and institutions. It highlights the need to develop standardized protocols when conducting toxicity-related predictions. This contribution articulates the information needed for protocols to support in silico predictions for major toxicological endpoints of concern (e.g., genetic toxicity, carcinogenicity, acute toxicity, reproductive toxicity, developmental toxicity) across several industries and regulatory bodies...
April 17, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29671216/video-assisted-thoracoscopic-bisegmentectomies-for-double-primary-lung-cancers-in-a-patient-with-situs-inversus-totalis
#13
Takuya Matsui, Kotaro Mizuno, Takeshi Yamada
Situs inversus totalis (SIT) is a rare anomaly. A limited number of reports document surgery for lung cancer in patients with SIT. We report the case of a 68-year-old man with SIT who underwent video-assisted thoracoscopic bisegmentectomies for synchronous double primary lung cancers. Preoperative evaluation of the pulmonary vessels and bronchus by three-dimensional computed tomography (CT) was unavailable owing to the patient's renal function disorder. However, the procedure was safely completed by adequate anatomic identification and careful operative manipulation based on plain CT study...
April 18, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29667017/underestimated-prevalence-of-heart-failure-in-hospital-inpatients-a-comparison-of-icd-codes-and-discharge-letter-information
#14
Mathias Kaspar, Georg Fette, Gülmisal Güder, Lea Seidlmayer, Maximilian Ertl, Georg Dietrich, Helmut Greger, Frank Puppe, Stefan Störk
BACKGROUND: Heart failure is the predominant cause of hospitalization and amongst the leading causes of death in Germany. However, accurate estimates of prevalence and incidence are lacking. Reported figures originating from different information sources are compromised by factors like economic reasons or documentation quality. METHODS: We implemented a clinical data warehouse that integrates various information sources (structured parameters, plain text, data extracted by natural language processing) and enables reliable approximations to the real number of heart failure patients...
April 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29643839/variance-component-selection-with-applications-to-microbiome-taxonomic-data
#15
Jing Zhai, Juhyun Kim, Kenneth S Knox, Homer L Twigg, Hua Zhou, Jin J Zhou
High-throughput sequencing technology has enabled population-based studies of the role of the human microbiome in disease etiology and exposure response. Microbiome data are summarized as counts or composition of the bacterial taxa at different taxonomic levels. An important problem is to identify the bacterial taxa that are associated with a response. One method is to test the association of specific taxon with phenotypes in a linear mixed effect model, which incorporates phylogenetic information among bacterial communities...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29643539/-construction-of-chemical-information-database-based-on-optical-structure-recognition-technique
#16
C Y Lv, M N Li, L R Zhang, Z M Liu
OBJECTIVE: To create a protocol that could be used to construct chemical information database from scientific literature quickly and automatically. METHODS: Scientific literature, patents and technical reports from different chemical disciplines were collected and stored in PDF format as fundamental datasets. Chemical structures were transformed from published documents and images to machine-readable data by using the name conversion technology and optical structure recognition tool CLiDE...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29643081/integration-of-risk-factors-for-parkinson-disease-in-2-large-longitudinal-cohorts
#17
Iris Y Kim, Éilis J O'Reilly, Katherine C Hughes, Xiang Gao, Michael A Schwarzschild, Marian T Hannan, Rebecca A Betensky, Alberto Ascherio
OBJECTIVE: To prospectively examine how selected lifestyle factors and family history of Parkinson disease (PD) combine to determine overall PD risk. METHODS: We derived risk scores among 69,968 women in the Nurses' Health Study (NHS) (1984-2012) and 45,830 men in the Health Professionals Follow-up Study (HPFS) (1986-2012). Risk scores were computed for each individual based on the following factors previously associated with PD risk: total caffeine intake, smoking, physical activity, and family history of PD for the NHS, and additionally total flavonoid intake and dietary urate index for the HPFS...
April 11, 2018: Neurology
https://www.readbyqxmd.com/read/29627490/genetically-determined-enlargement-of-carotid-body-evaluated-using-computed-angiotomography
#18
Przemysław Jaźwiec, Paweł Gać, Monika Chaszczewska-Markowska, Katarzyna Bogunia-Kubik, Grzegorz Mazur, Rafał Poręba
It has recently been established that carotid bodies play a significant role in the regulation of activities of the cardiovascular system as well as in the pathogenesis of arterial hypertension, heart failure and diabetes. Aim of study was to determinate the influence of polymorphisms within genes of the renin-angiotensin-aldosterone system (RAAS) on the volume of the carotid bodies (CB) in patients with hypertension (HTA). The study group consisted of 77 patients with HTA. All patients were genotyped for single-nucleotide polymorphisms of genes coding for: angiotensinogen: rs4762, rs5049, rs5051 and rs699; angiotensin-converting enzyme: rs4343; angiotensin receptor type 1 gene (AGTR1): rs5182 and rs5186; and the aldosterone synthase: rs1799998...
April 5, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29626838/integrated-computer-aided-forensic-case-analysis-presentation-and-documentation-based-on-multimodal-3d-data
#19
Alexander Bornik, Martin Urschler, Dieter Schmalstieg, Horst Bischof, Astrid Krauskopf, Thorsten Schwark, Eva Scheurer, Kathrin Yen
Three-dimensional (3D) crime scene documentation using 3D scanners and medical imaging modalities like computed tomography (CT) and magnetic resonance imaging (MRI) are increasingly applied in forensic casework. Together with digital photography, these modalities enable comprehensive and non-invasive recording of forensically relevant information regarding injuries/pathologies inside the body and on its surface. Furthermore, it is possible to capture traces and items at crime scenes. Such digitally secured evidence has the potential to similarly increase case understanding by forensic experts and non-experts in court...
March 23, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29618961/exploring-midwives-need-and-intention-to-adopt-electronic-integrated-antenatal-care
#20
Hosizah Markam, Harry Hochheiser, Kuntoro Kuntoro, Hari Basuki Notobroto
Documentation requirements for the Indonesian integrated antenatal care (ANC) program suggest the need for electronic systems to address gaps in existing paper documentation practices. Our goals were to quantify midwives' documentation completeness in a primary healthcare center, understand documentation challenges, develop a tool, and assess intention to use the tool. We analyzed existing ANC records in a primary healthcare center in Bangkalan, East Java, and conducted interviews with stakeholders to understand needs for an electronic system in support of ANC...
2018: Perspectives in Health Information Management
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