Raihan Chowdhury, Shimul Bhuia, Asraful Islam Rakib, Sakib Al Hasan, Manik Chandra Shill, Heba A S El-Nashar, Mohamed El-Shazly, Muhammad Torequl Islam
Gigantol, a bibenzyl compound extracted from various medicinal plants, has shown a number of biological activities, making it an attractive candidate for potential medical applications. This systematic review aims to shed light on gigantol's promising role in inflammation treatment and its underlying mechanisms. Gigantol exhibits potential anti-inflammatory properties in pre-clinical pharmacological test systems. It effectively reduced the levels of pro-inflammatory markers and arachidonic acid metabolites through various pathways, such as NF-κB, AKT, PI3K, and JNK/cPLA2/12-LOX...
April 16, 2024: Natural Product Research