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https://www.readbyqxmd.com/read/28918672/protein-complexes-big-data-machine-learning-and-integrative-proteomics-lessons-learned-over-a-decade-of-systematic-analysis-of-protein-interaction-networks
#1
Pierre C Havugimana, Pingzhao Hu, Andrew Emili
Elucidation of the networks of physical (functional) interactions present in cells and tissues is fundamental for understanding the molecular organization of biological systems, the mechanistic basis of essential and disease-related processes, and for functional annotation of previously uncharacterized proteins (via guilt-by-association or -correlation). After a decade in the field, we felt it timely to document our own experiences in the systematic analysis of protein interaction networks. Areas covered: Researchers worldwide have contributed innovative experimental and computational approaches that have driven the rapidly evolving field of 'functional proteomics'...
September 18, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28910858/overview-of-methods-and-strategies-for-conducting-virtual-small-molecule-screening
#2
Xavier Fradera, Kerim Babaoglu
Virtual screening (VS) in the context of drug discovery is the use of computational methods to discover novel ligands with a desired biological activity from within a larger collection of molecules. These techniques have been in use for many years, there is a wide range of methodologies available, and many successful applications have been reported in the literature. VS is often used as an alternative or a complement to High-throughput screening (HTS) or other methods to identify ligands for target validation or medicinal chemistry projects...
September 14, 2017: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/28905170/-follow-up-ultrasound-of-head-and-neck-cancer
#3
J Künzel, A Bozzato, S Strieth
In Germany high-resolution sonography using the color duplex mode in addition to computed tomography (CT) is a well-established and proven method in the context of restaging after primary therapy of head and neck squamous cell cancer (HNSCC). There are no international evidence-based restaging guidelines. Decisions concerning neck dissection (ND) after primary radiochemotherapy (RCT) are often individually derived in the respective tumor conferences and are therefore subject to variance. Compared to the UK or USA, in Germany there is a high level of expertise in the use of ultrasound in combination with CT for the routine restaging of HNSCC after RCT...
September 13, 2017: HNO
https://www.readbyqxmd.com/read/28895433/corrective-osteotomies-of-phalangeal-and-metacarpal-malunions-using-patient-specific-guides-ct-based-evaluation-of-the-reduction-accuracy
#4
Stefanie Hirsiger, Andreas Schweizer, Junichi Miyake, Ladislav Nagy, Philipp Fürnstahl
BACKGROUND: Surgical planning of corrective osteotomies is traditionally based on conventional radiographs and clinical findings. In the past 10 years, 3-dimensional (3D) preoperative planning approaches with patient-specific guides have been developed. However, the application of this technology to posttraumatic deformities of the metacarpals and phalangeal bones has not yet been investigated. Our goal was to evaluate the feasibility of the surgical application to the latter and to evaluate the extent and precision of correction...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28891406/clinical-practice-guideline-evaluation-of-the-neck-mass-in-adults
#5
Melissa A Pynnonen, M Boyd Gillespie, Benjamin Roman, Richard M Rosenfeld, David E Tunkel, Laura Bontempo, Itzhak Brook, Davoren Ann Chick, Maria Colandrea, Sandra A Finestone, Jason C Fowler, Christopher C Griffith, Zeb Henson, Corinna Levine, Vikas Mehta, Andrew Salama, Joseph Scharpf, Deborah R Shatzkes, Wendy B Stern, Jay S Youngerman, Maureen D Corrigan
Objective Neck masses are common in adults, but often the underlying etiology is not easily identifiable. While infections cause most of the neck masses in children, most persistent neck masses in adults are neoplasms. Malignant neoplasms far exceed any other etiology of adult neck mass. Importantly, an asymptomatic neck mass may be the initial or only clinically apparent manifestation of head and neck cancer, such as squamous cell carcinoma (HNSCC), lymphoma, thyroid, or salivary gland cancer. Evidence suggests that a neck mass in the adult patient should be considered malignant until proven otherwise...
September 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28890556/ethnicity-and-upper-airway-measurements-a-study-in-south-indian-population
#6
Kalpana P Balakrishnan, Punitha A Chockalingam
BACKGROUND AND AIMS: Most studies on upper airway are conducted based on airway measurements in the western population. We set out to find the normal values of upper airway measurements in South Indian population. The aim of this study was to perform various upper airway examinations and to set standards for normal measurements in the South Indian population as well as to analyse the data for predictors of difficult intubation. METHODS: This prospective observational study was conducted in a tertiary cancer hospital in Southern India...
August 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28885940/collaborative-systems-biology-projects-for-the-military-medical-community
#7
Jeffrey J Zalatoris, Julia B Scheerer, Frank J Lebeda
INTRODUCTION: This pilot study was conducted to examine, for the first time, the ongoing systems biology research and development projects within the laboratories and centers of the U.S. Army Medical Research and Materiel Command (USAMRMC). The analysis has provided an understanding of the breadth of systems biology activities, resources, and collaborations across all USAMRMC subordinate laboratories. METHODS: The Systems Biology Collaboration Center at USAMRMC issued a survey regarding systems biology research projects to the eight U...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28885238/improving-the-implementation-of-lung-cancer-screening-guidelines-at-an-academic-primary-care-practice
#8
Alison T Brenner, Laura Cubillos, Katherine Birchard, Caleb Doyle-Burr, John Eick, Louise Henderson, Laura Jones, Michael Massaro, Bailey Minish, Paul Molina, Michael Pignone, Shana Ratner, Maria Patricia Rivera, Daniel S Reuland
Expert groups recommend annual chest computed tomography for lung cancer screening (LCS) in high-risk patients. Lung cancer screening in primary care is a complex process that includes identification of the at-risk population, comorbidity assessment, and shared decision making. We identified three key processes required for high-quality screening implementation in our academic primary care practice: (1) systematic collection of lifetime cumulative smoking history to identify potentially eligible patients; (2) visit-based clinical reminders and order sets embedded in the electronic health record (EHR); and (3) tools to facilitate shared decision making and appropriate test ordering...
September 1, 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/28883671/a-three-phase-decision-model-of-computer-aided-coding-for-the-iranian-classification-of-health-interventions-irchi
#9
Zahra Azadmanjir, Reza Safdari, Marjan Ghazisaeedi, Mehrshad Mokhtaran, Mohammad Esmail Kameli
INTRODUCTION: Accurate coded data in the healthcare are critical. Computer-Assisted Coding (CAC) is an effective tool to improve clinical coding in particular when a new classification will be developed and implemented. But determine the appropriate method for development need to consider the specifications of existing CAC systems, requirements for each type, our infrastructure and also, the classification scheme. AIM: The aim of the study was the development of a decision model for determining accurate code of each medical intervention in Iranian Classification of Health Interventions (IRCHI) that can be implemented as a suitable CAC system...
June 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28882491/anatomic-and-high-resolution-computed-tomographic-angiography-study-of-the-lateral-femoral-condyle-flap-implications-for-surgical-dissection
#10
Mohamed Morsy, Yoo Joon Sur, Osman Akdag, Amr Eisa, Tarek A El-Gammal, Nirusha Lachman, Steven L Moran
BACKGROUND: The lateral femoral condyle (LFC) flap is a vascularized bone flap based on the superior lateral genicular artery (SLGA). Harvest technique for this flap has not yet been demonstrated. The purpose of this study was to better delineate the blood supply to the bone and skin of this flap to allow for a safe and effective harvest. MATERIALS AND METHODS: Twenty-three lower extremities were injected with latex or a mixture of latex and barium sulfate. The SLGA was identified and dissected, documenting the course, diameter, anatomical relations, length, and branches...
August 16, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28881966/dextmp-deep-dive-into-text-for-predicting-moonlighting-proteins
#11
Ishita K Khan, Mansurul Bhuiyan, Daisuke Kihara
Motivation: Moonlighting proteins (MPs) are an important class of proteins that perform more than one independent cellular function. MPs are gaining more attention in recent years as they are found to play important roles in various systems including disease developments. MPs also have a significant impact in computational function prediction and annotation in databases. Currently MPs are not labeled as such in biological databases even in cases where multiple distinct functions are known for the proteins...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28870432/the-pseudo-ct-myelogram-sign-an-aid-to-the-diagnosis-of-underlying-brain-stem-and-spinal-cord-trauma-in-the-presence-of-major-craniocervical-region-injury-on-post-mortem-ct
#12
F Bolster, Z Ali, B Daly
AIM: To document the detection of underlying low-attenuation spinal cord or brain stem injuries in the presence of the "pseudo-CT myelogram sign" (PCMS) on post-mortem computed tomography (PMCT). MATERIALS AND METHODS: The PCMS was identified on PMCT in 20 decedents (11 male, nine female; age 3-83 years, mean age 35.3 years) following fatal blunt trauma at a single forensic centre. Osseous and ligamentous craniocervical region injuries and brain stem or spinal cord trauma detectable on PMCT were recorded...
September 1, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28861821/3d-printing-of-plant-golgi-stacks-from-their-electron-tomographic-models
#13
Keith Ka Ki Mai, Madison J Kang, Byung-Ho Kang
Three-dimensional (3D) printing is an effective tool for preparing tangible 3D models from computer visualizations to assist in scientific research and education. With the recent popularization of 3D printing processes, it is now possible for individual laboratories to convert their scientific data into a physical form suitable for presentation or teaching purposes. Electron tomography is an electron microscopy method by which 3D structures of subcellular organelles or macromolecular complexes are determined at nanometer-level resolutions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28851337/which-online-format-is-most-effective-for-assisting-baby-boomers-to-complete-advance-directives-a-randomised-controlled-trial-of-email-prompting-versus-online-education-module
#14
Sandra L Bradley, Jennifer J Tieman, Richard J Woodman, Paddy A Phillips
BACKGROUND: Completion of Advance Directives (ADs), being financial and healthcare proxy or instructional documents, is relatively uncommon in Australia. Efforts to increase completion rates include online education and prompting which past literature suggests may be effective. The aim of this randomized controlled trial was to assess computer-based online AD information and email prompting for facilitating completion of ADs by Australian Baby Boomers (b.1946-1965) as well as factors which may impede or assist completion of these documents by this generation when using the online environment...
August 29, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28841546/transfer-learning-a-riemannian-geometry-framework-with-applications-to-brain-computer-interfaces
#15
Paolo Zanini, Marco Congedo, Christian Jutten, Salem Said, Yannick Berthoumieu
OBJECTIVE: This paper tackles the problem of transfer learning in the context of EEG-based Brain Computer Interface (BCI) classification. In particular the problems of cross-session and cross-subject classification are considered. These problems concern the ability to use data from previous sessions or from a database of past users to calibrate and initialize the classifier, allowing a calibration-less BCI mode of operation. METHODS: Data are represented using spatial covariance matrices of the EEG signals, exploiting the recent successful techniques based on the Riemannian geometry of the manifold of Symmetric Positive Definite (SPD) matrices...
August 21, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28837975/-required-framework-for-the-collection-of-real-life-data-an-example-from-university-eye-hospital-munich
#16
Karsten Kortüm, Christoph Kern, Gerhard Meyer, Siegfried Priglinger, Christoph Hirneiß
Background The importance of evaluating real-life data is constantly increasing. Currently available computer systems better allow for analyses of data, as more and more data is available in a digital form. Before a project for real-life data analyses is started, technical considerations and staff, legal, and data protection procedures need to be addressed. In this manuscript, experiences made at the University Eye Hospital in Munich will be shared. Materials and Methods Legal requirements, as found in laws and guidelines governing documentation and data privacy, are highlighted...
August 24, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28834966/checklist-and-scoring-system-for-the-assessment-of-soft%C3%A2-tissue-preservation-in-ct-examinations-of-human-mummies-application-to-the-tyrolean-iceman
#17
Stephanie Panzer, Patrizia Pernter, Dario Piombino-Mascali, Rimantas Jankauskas, Stephanie Zesch, Wilfried Rosendahl, Gerhard Hotz, Albert R Zink
Purpose Soft tissues make a skeleton into a mummy and they allow for a diagnosis beyond osteology. Following the approach of structured reporting in clinical radiology, a recently developed checklist was used to evaluate the soft tissue preservation status of the Tyrolean Iceman using computed tomography (CT). The purpose of this study was to apply the "Checklist and Scoring System for the Assessment of Soft Tissue Preservation in CT Examinations of Human Mummies" to the Tyrolean Iceman, and to compare the Iceman's soft tissue preservation score to the scores calculated for other mummies...
August 23, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28832945/occurrence-of-osteon-banding-in-adult-human-cortical-bone
#18
Janna M Andronowski, Isaac V Pratt, David M L Cooper
OBJECTIVES: Differentiating human from nonhuman fragmented bone is often accomplished using histological methods if the observation of gross morphology proves insufficient. Linearly oriented primary and/or secondary osteonal systems, commonly referred to as osteon bands, are described as a strong indicator of nonhuman bone, particularly the occurrence of multiple bands. This phenomenon has been conventionally documented using two-dimensional (2D) histology, but such analyses are destructive and typically limited to a single cross-section...
August 19, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28832633/can-facts-trump-unconditional-trust-evidence-based-information-halves-the-influence-of-physicians-non-evidence-based-cancer-screening-recommendations
#19
Odette Wegwarth, Gert G Wagner, Gerd Gigerenzer
Informed decision making in medicine, defined as basing one's decision on the best current medical evidence, requires both informed physicians and informed patients. In cancer screening, however, studies document that these prerequisites are not yet met. Many physicians do not know or understand the medical evidence behind screening tests, do not adequately counsel (asymptomatic) people on screening, and make recommendations that conflict with existing guidelines on informed choice. Consistent with this situation, nation-wide studies showed that the general public misperceives the contribution of cancer screening but that understanding considerably improves when evidence-based information is provided...
2017: PloS One
https://www.readbyqxmd.com/read/28832273/test-retest-reliability-and-practice-effects-for-the-anam-general-neuropsychological-screening-battery
#20
Andrea S Vincent, Tresa M Roebuck-Spencer, Eugenia Fuenzalida, Kirby Gilliland
OBJECTIVE: As the use of computer-based neurocognitive assessment is rapidly expanding, the need to systematically study and document key psychometric properties of these measures has become increasingly more salient. To meet this aim, this study examined test-retest reliability and practice effects for the Automated Neuropsychological Assessment Metrics General Neuropsychological Screening battery (ANAM GNS) in a sample of 94 community dwelling adults. METHOD: ANAM GNS was administered and then repeated (alternate form) after 30 days...
August 23, 2017: Clinical Neuropsychologist
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