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https://www.readbyqxmd.com/read/29289930/nanomaterials-at-the-neural-interface
#1
REVIEW
Denis Scaini, Laura Ballerini
Interfacing the nervous system with devices able to efficiently record or modulate the electrical activity of neuronal cells represents the underlying foundation of future theranostic applications in neurology and of current openings in neuroscience research. These devices, usually sensing cell activity via microelectrodes, should be characterized by safe working conditions in the biological milieu together with a well-controlled operation-life. The stable device/neuronal electrical coupling at the interface requires tight interactions between the electrode surface and the cell membrane...
December 28, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29285401/multifunctional-stimuli-responsive-polymer-gated-iron-and-gold-embedded-silica-nano-golf-balls-nanoshuttles-for-targeted-on-demand-theranostics
#2
Liping Wang, Grace Jang, Deependra Kumar Ban, Vrinda Sant, Jay Seth, Sami Kazmi, Nirav Patel, Qingqing Yang, Joon Lee, Woraphong Janetanakit, Shanshan Wang, Brian P Head, Gennadi Glinsky, Ratneshwar Lal
Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles (NP)-embedded silica nanoshuttles (MGNSs) with nanopores on their surface. Fluorescently labeled Doxorubicin (DOX), a cancer drug, was loaded in the MGNSs as a payload...
2017: Bone Research
https://www.readbyqxmd.com/read/29246925/a%C3%AE-mediates-f-actin-disassembly-in-dendritic-spines-leading-to-cognitive-deficits-in-alzheimer-s-disease
#3
Reddy Peera Kommaddi, Debajyoti Das, Smitha Karunakaran, Siddharth Nanguneri, Deepti Bapat, Ajit Ray, Eisha Shaw, David A Bennett, Deepak Nair, Vijayalakshmi Ravindranath
Dendritic spine loss is recognized as an early feature of Alzheimer's disease, however the underlying mechanisms are poorly understood. Dendritic spine structure is defined by filamentous actin (F-actin) and we observed depolymerization of synaptosomal F-actin accompanied by increased G-actin, as early as 1 month of age in a mouse model of Alzheimer's disease (AD; APPswe/PS1ΔE9, male mice). This led to recall deficit after contextual fear conditioning (cFC) at 2 months of age in APPswe/PS1ΔE9 male mice, which could be reversed by actin polymerizing agent, jasplakinolide...
December 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29243172/therapeutic-delivery-of-simvastatin-loaded-in-pla-peg-polymersomes-resulted-in-amplification-of-anti-inflammatory-effects-in-activated-microglia
#4
Dharani Manickavasagam, Kimberly Novak, Moses O Oyewumi
Simvastatin (Sim), a lipid-lowering drug has been studied in chronic neuroinflammation associated with degenerative brain disorders due to its potential protective properties against inflammatory reaction, oxidative damage, neuronal dysfunction, and death. Meanwhile, potential application of Sim in neuroinflammation will require a suitable delivery system that can overcome notable challenges pertaining to poor blood-brain barrier (BBB) permeability and side/off-target effects. Herein, we engineered and characterized nano-sized polymersomes loaded with Sim (Sim-Ps) using PEG-PdLLA (methoxy polyethylene glycol-poly(D,L) lactic acid) diblock co-polymers...
December 14, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29242993/promotion-of-neuronal-regeneration-by-using-self-polymerized-dendritic-polypeptide-scaffold-for-spinal-cord-tissue-engineering
#5
Jun Ming Wan, Liang le Liu, Jian Fang Zhang, Jian Wei Lu, Qi Li
Tissue engineering technology is applicable for study of nerve regeneration after spinal cord injury. Many natural and artificial scaffold are not applicable because of poor mechanical properties and cell compatibility. Polypeptides with fine three-dimensional structure and cell compatibility and are widely used in tissue engineering research. The purpose of this study was to verify the neuronal differentiation of neural stem cells by using self-polymerize dendritic polypeptide for spinal cord tissue engineering...
December 14, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29231734/t-snare-transmembrane-domain-clustering-modulates-lipid-organization-and-membrane-curvature
#6
Satyan Sharma, Manfred Lindau
The t-SNARE complex plays a central role in neuronal fusion. Its components, syntaxin-1 and SNAP25, are largely present in individual clusters and partially colocalize at the presumptive fusion site. How these protein clusters modify local lipid composition and membrane morphology is largely unknown. In this work, using coarse-grained molecular dynamics, the transmembrane domains (TMDs) of t-SNARE complexes are shown to form aggregates leading to formation of lipid nanodomains, which are enriched in cholesterol, phosphatidylinositol 4,5-bisphosphate, and gangliosidic lipids...
December 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29227456/photopolymerized-microfeatures-guide-adult-spiral-ganglion-and-dorsal-root-ganglion-neurite-growth
#7
Linjing Xu, Alison E Seline, Braden Leigh, Mark Ramirez, C Allan Guymon, Marlan R Hansen
HYPOTHESIS: Microtopographical patterns generated by photopolymerization of methacrylate polymer systems will direct growth of neurites from adult neurons, including spiral ganglion neurons (SGNs). BACKGROUND: Cochlear implants (CIs) provide hearing perception to patients with severe to profound hearing loss. However, their ability to encode complex auditory stimuli is limited due, in part, to poor spatial resolution caused by spread of the electrical currents in the inner ear...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29218789/precise-localizations-of-voltage-gated-sodium-and-potassium-channels-in-neurons
#8
REVIEW
Hiroaki Misonou
Neurons are extremely large and complex cells, and they regulate membrane potentials in multiple subcellular compartments using a variety of ion channels. Voltage-gated sodium (Nav) and potassium (Kv) channels are crucial in regulating neuronal membrane excitability owing to their diversity in subtypes, biophysical properties, and localizations. In particular, specific localizations of Nav and Kv channels in specific membrane compartments are essential to achieve a precise control of local membrane excitability...
December 8, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29208270/nano-fibrous-and-ladder-like-multi-channel-nerve-conduits-degradation-and-modification-by-gelatin
#9
Sheng Liu, Xiumin Sun, Tao Wang, Shihao Chen, Chen-Guang Zeng, Gaoyi Xie, Qingtang Zhu, Xiaolin Liu, Daping Quan
We recently fabricated multi-channel PLLA nerve conduits (NCs, conduits diameter: ~3mm, channels diameter: ~200μm) with nano-fibrous microstructure (NNCs) and ladder-like microstructure (LNCs), and found the nanofibers in the NNCs promote differentiation of nerve stem cells (NSCs) into neurons. In the present study, we evaluated the degradation profile of NNCs and LNCs, and observed that NNCs degraded too fast to implant. To delay the degradation and retain the nano-scale effect of NNCs, we used gelatin to wrap (2% w/v gelatin) or embed (8% w/v gelatin) NNCs and LNCs via vacuum infusion and chemical cross-linking with genipin...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29142171/sub-toxic-concentrations-of-nano-zno-and-nano-tio2-suppress-neurite-outgrowth-in-differentiated-pc12-cells
#10
Tomohiko Irie, Tsuyoshi Kawakami, Kaoru Sato, Makoto Usami
Nanomaterials have been extensively used in our daily life, and may also induce health effects and toxicity. Nanomaterials can translocate from the outside to internal organs, including the brain. For example, both nano-ZnO and nano-TiO2 translocate into the brain via the olfactory pathway in rodents, possibly leading to toxic effects on the brain. Although the effects of nano-ZnO and nano-TiO2 on neuronal viability or neuronal excitability have been studied, no work has focused on how these nanomaterials affect neuronal differentiation and development...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29097785/the-nano-architecture-of-the-axonal-cytoskeleton
#11
REVIEW
Christophe Leterrier, Pankaj Dubey, Subhojit Roy
The corporeal beauty of the neuronal cytoskeleton has captured the imagination of generations of scientists. One of the easiest cellular structures to visualize by light microscopy, its existence has been known for well over 100 years, yet we have only recently begun to fully appreciate its intricacy and diversity. Recent studies combining new probes with super-resolution microscopy and live imaging have revealed surprising details about the axonal cytoskeleton and, in particular, have discovered previously unknown actin-based structures...
December 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29075833/transcriptome-profiling-of-neurosensory-perception-genes-in-wing-tissue-of-two-evolutionary-distant-insect-orders-diptera-drosophila-melanogaster-and-hemiptera-acyrthosiphon-pisum
#12
Sandra Agnel, Martine da Rocha, Alain Robichon
The neurogenesis and neuronal functions in insect wing have been understudied mainly due to technical hindrances that have prevented electrophysiology studies for decades. The reason is that the nano-architecture of the wing chemosensory bristles hampers the receptors accessibility of odorants/tastants to receptors in fixed setup, whereas in nature, the wing flapping mixes these molecules in bristle lymph. In this report, we analyzed the transcriptome of the wing tissue of two species phylogenetically strongly divergent: Drosophila melanogaster a generic model for diptera order (complete metamorphosis) and the aphid acyrthosiphon pisum, representative of hemiptera order (incomplete metamorphosis) for which a conditional winged/wingless polyphenism is under control of population density and resources...
October 26, 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/29064377/3d-printing-nano-conductive-multi-walled-carbon-nanotube-scaffolds-for-nerve-regeneration
#13
Se-Jun Lee, Wei Zhu, Margaret Nowicki, Grace Lee, Dong Nyoung Heo, Junghoon Kim, Yi Zuo, Lijie Grace Zhang
In recent years, the development of tissue-engineered 3D scaffolds for various regenerative engineering applications has been widely investigated. Hydrogel polymers are extensively used as tissue engineering scaffold materials due to their unique biocompatible features. However, hydrogel based scaffolds often suffer from weak mechanical strength and a lack of functional groups to enhance cell adhesion. Hence, nanomaterials, such as carbon nanotubes (CNTs), have been introduced to modify the surface properties of scaffolds, thus enhancing the interaction between the neural cells and biomaterials...
October 24, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29035351/rebalancing-%C3%AE-amyloid-induced-decrease-of-atp-level-by-amorphous-nano-micro-polyphosphate-suppression-of-the-neurotoxic-effect-of-amyloid-%C3%AE-protein-fragment-25-35
#14
Werner E G Müller, Shunfeng Wang, Maximilian Ackermann, Meik Neufurth, Renate Steffen, Egherta Mecja, Rafael Muñoz-Espí, Qingling Feng, Heinz C Schröder, Xiaohong Wang
Morbus Alzheimer neuropathology is characterized by an impaired energy homeostasis of brain tissue. We present an approach towards a potential therapy of Alzheimer disease based on the high-energy polymer inorganic polyphosphate (polyP), which physiologically occurs both in the extracellular and in the intracellular space. Rat pheochromocytoma (PC) 12 cells, as well as rat primary cortical neurons were exposed to the Alzheimer peptide Aβ25-35. They were incubated in vitro with polyphosphate (polyP); ortho-phosphate was used as a control...
October 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29031405/life-span-resolved-nanotoxicology-enables-identification-of-age-associated-neuromuscular-vulnerabilities-in-the-nematode-caenorhabditis-elegans
#15
Annette Piechulek, Anna von Mikecz
At present, the majority of investigations concerning nanotoxicology in the nematode C. elegans address short-term effects. While this approach allows for the identification of uptake pathways, exposition and acute toxicity, nanoparticle-organism interactions that manifest later in the adult life of C. elegans are missed. Here we show that a microhabitat composed of liquid S-medium and live bacteria in microtiter wells prolongs C. elegans longevity and is optimally suited to monitor chronic eNP-effects over the entire life span (about 34 days) of the nematode...
October 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29026644/wet-spinning-fabrication-of-shear-patterned-alginate-hydrogel-microfibers-and-the-guidance-of-cell-alignment
#16
You Yang, Jing Sun, Xiaolu Liu, Zhenzhen Guo, Yunhu He, Dan Wei, Meiling Zhong, Likun Guo, Hongsong Fan, Xingdong Zhang
Native tissue is naturally comprised of highly-ordered cell-matrix assemblies in a multi-hierarchical way, and the nano/submicron alignment of fibrous matrix is found to be significant in supporting cellular functionalization. In this study, a self-designed wet-spinning device appended with a rotary receiving pool was used to continuously produce shear-patterned hydrogel microfibers with aligned submicron topography. The process that the flow-induced shear force reshapes the surface of hydrogel fiber into aligned submicron topography was systematically analysed...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29021705/global-analysis-of-ginsenoside-rg1-protective-effects-in-%C3%AE-amyloid-treated-neuronal-cells
#17
Ji Seon Shim, Min-Young Song, Sung-Vin Yim, Seung-Eun Lee, Kang-Sik Park
BACKGROUND: A number of reports have described the protective effects of ginsenoside Rg1 (Rg1) in Alzheimer's disease (AD). However, the protective mechanisms of Rg1 in AD remain elusive. METHODS: To investigate the potential mechanisms of Rg1 in β-amyloid peptide-treated SH-SY5Y cells, a comparative proteomic analysis was performed using stable isotope labeling with amino acids in cell culture combined with nano-LC-MS/MS. RESULTS: We identified a total of 1,149 proteins in three independent experiments...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28981426/equivalent-circuit-of-the-neuro-electronic-junction-for-signal-recordings-from-planar-and-engulfed-micro-nano-electrodes
#18
Giuseppe Massobrio, Sergio Martinoia, Paolo Massobrio
In the latest years, several attempts to develop extracellular microtransducers to record electrophysiological activity of excitable cells have been done. In particular, many efforts have been oriented to increase the coupling conditions, and, thus, improving the quality of the recorded signal. Gold mushroom-shaped microelectrodes (GMμE) are an example of nano-devices to achieve those requirements. In this study, we developed an equivalent electrical circuit of the neuron-microelectrode system interface to simulate signal recordings from both planar and engulfed micro-nano-electrodes...
October 5, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28962965/effects-of-nanoparticle-encapsulated-curcumin-on-hiv-gp120-associated-neuropathic-pain-induced-by-the-p2x3-receptor-in-dorsal-root-ganglia
#19
Shanhong Zhao, Jinpu Yang, Xinyao Han, Yingxin Gong, Shenqiang Rao, Bing Wu, Zhihua Yi, Lifang Zou, Tianyu Jia, Lin Li, Huilong Yuan, Liran Shi, Chunping Zhang, Yun Gao, Guilin Li, Shuangmei Liu, Hong Xu, Hui Liu, Shangdong Liang
HIV-1 envelope glycoprotein (Glycoprotein 120, gp120) can directly stimulate primary sensory afferent neurons and cause chronic neuropathic pain. The P2X3 receptor in the dorsal root ganglia (DRG) is associated with the transmission of neuropathic pain. Curcumin isolated from the herb Curcuma rhizome has anti-inflammatory and anti-tumor effects. The water solubility, targeting and bioavailability of curcumin can be improved by nanoparticle encapsulation. In this study, we sought to explore the effects of nanoparticle-encapsulated curcumin (nano curcumin) on HIV-gp120-induced neuropathic pain mediated by the P2X3 receptor in DRG neurons...
September 28, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28939873/brain-inflammation-blood-brain-barrier-dysfunction-and-neuronal-synaptophysin-decrease-after-inhalation-exposure-to-titanium-dioxide-nano-aerosol-in-aging-rats
#20
Clémence Disdier, Monique Chalansonnet, François Gagnaire, Laurent Gaté, Frédéric Cosnier, Jérôme Devoy, Wadad Saba, Amie K Lund, Emilie Brun, Aloïse Mabondzo
Notwithstanding potential neurotoxicity of inhaled titanium dioxide nanoparticles (TiO2 NPs), the toxicokinetics and consequences on blood-brain barrier (BBB) function remain poorly characterized. To improve risk assessment, we need to evaluate the impact on BBB under realistic environmental conditions and take into account vulnerability status such as age. 12-13 week and 19-month-old male rats were exposed by inhalation to 10 mg/m(3) of TiO2 nano-aerosol (6 hrs/day, 5 day/week, for 4 weeks). We showed an age-dependent modulation of BBB integrity parameters suggesting increased BBB permeability in aging rats...
September 22, 2017: Scientific Reports
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