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https://www.readbyqxmd.com/read/29142171/sub-toxic-concentrations-of-nano-zno-and-nano-tio2-suppress-neurite-outgrowth-in-differentiated-pc12-cells
#1
Tomohiko Irie, Tsuyoshi Kawakami, Kaoru Sato, Makoto Usami
Nanomaterials have been extensively used in our daily life, and may also induce health effects and toxicity. Nanomaterials can translocate from the outside to internal organs, including the brain. For example, both nano-ZnO and nano-TiO2 translocate into the brain via the olfactory pathway in rodents, possibly leading to toxic effects on the brain. Although the effects of nano-ZnO and nano-TiO2 on neuronal viability or neuronal excitability have been studied, no work has focused on how these nanomaterials affect neuronal differentiation and development...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29097785/the-nano-architecture-of-the-axonal-cytoskeleton
#2
REVIEW
Christophe Leterrier, Pankaj Dubey, Subhojit Roy
The corporeal beauty of the neuronal cytoskeleton has captured the imagination of generations of scientists. One of the easiest cellular structures to visualize by light microscopy, its existence has been known for well over 100 years, yet we have only recently begun to fully appreciate its intricacy and diversity. Recent studies combining new probes with super-resolution microscopy and live imaging have revealed surprising details about the axonal cytoskeleton and, in particular, have discovered previously unknown actin-based structures...
December 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29075833/transcriptome-profiling-of-neurosensory-perception-genes-in-wing-tissue-of-two-evolutionary-distant-insect-orders-diptera-drosophila-melanogaster-and-hemiptera-acyrthosiphon-pisum
#3
Sandra Agnel, Martine da Rocha, Alain Robichon
The neurogenesis and neuronal functions in insect wing have been understudied mainly due to technical hindrances that have prevented electrophysiology studies for decades. The reason is that the nano-architecture of the wing chemosensory bristles hampers the receptors accessibility of odorants/tastants to receptors in fixed setup, whereas in nature, the wing flapping mixes these molecules in bristle lymph. In this report, we analyzed the transcriptome of the wing tissue of two species phylogenetically strongly divergent: Drosophila melanogaster a generic model for diptera order (complete metamorphosis) and the aphid acyrthosiphon pisum, representative of hemiptera order (incomplete metamorphosis) for which a conditional winged/wingless polyphenism is under control of population density and resources...
October 26, 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/29064377/3d-printing-nano-conductive-multi-walled-carbon-nanotube-scaffolds-for-nerve-regeneration
#4
Se-Jun Lee, Wei Zhu, Margaret Nowicki, Grace Lee, Dong Nyoung Heo, Junghoon Kim, Yi Zuo, Lijie Grace Zhang
In recent years, the development of tissue-engineered 3D scaffolds for various regenerative engineering applications has been widely investigated. Hydrogel polymers are extensively used as tissue engineering scaffold materials due to their unique biocompatible features. However, hydrogel based scaffolds often suffer from weak mechanical strength and a lack of functional groups to enhance cell adhesion. Hence, nanomaterials, such as carbon nanotubes (CNTs), have been introduced to modify the surface properties of scaffolds, thus enhancing the interaction between the neural cells and biomaterials...
October 24, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29035351/rebalancing-%C3%AE-amyloid-induced-decrease-of-atp-level-by-amorphous-nano-micro-polyphosphate-suppression-of-the-neurotoxic-effect-of-amyloid-%C3%AE-protein-fragment-25-35
#5
Werner E G Müller, Shunfeng Wang, Maximilian Ackermann, Meik Neufurth, Renate Steffen, Egherta Mecja, Rafael Muñoz-Espí, Qingling Feng, Heinz C Schröder, Xiaohong Wang
Morbus Alzheimer neuropathology is characterized by an impaired energy homeostasis of brain tissue. We present an approach towards a potential therapy of Alzheimer disease based on the high-energy polymer inorganic polyphosphate (polyP), which physiologically occurs both in the extracellular and in the intracellular space. Rat pheochromocytoma (PC) 12 cells, as well as rat primary cortical neurons were exposed to the Alzheimer peptide Aβ25-35. They were incubated in vitro with polyphosphate (polyP); ortho-phosphate was used as a control...
October 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29031405/life-span-resolved-nanotoxicology-enables-identification-of-age-associated-neuromuscular-vulnerabilities-in-the-nematode-caenorhabditis-elegans
#6
Annette Piechulek, Anna von Mikecz
At present, the majority of investigations concerning nanotoxicology in the nematode C. elegans address short-term effects. While this approach allows for the identification of uptake pathways, exposition and acute toxicity, nanoparticle-organism interactions that manifest later in the adult life of C. elegans are missed. Here we show that a microhabitat composed of liquid S-medium and live bacteria in microtiter wells prolongs C. elegans longevity and is optimally suited to monitor chronic eNP-effects over the entire life span (about 34 days) of the nematode...
October 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29026644/wet-spinning-fabrication-of-shear-patterned-alginate-hydrogel-microfibers-and-the-guidance-of-cell-alignment
#7
You Yang, Jing Sun, Xiaolu Liu, Zhenzhen Guo, Yunhu He, Dan Wei, Meiling Zhong, Likun Guo, Hongsong Fan, Xingdong Zhang
Native tissue is naturally comprised of highly-ordered cell-matrix assemblies in a multi-hierarchical way, and the nano/submicron alignment of fibrous matrix is found to be significant in supporting cellular functionalization. In this study, a self-designed wet-spinning device appended with a rotary receiving pool was used to continuously produce shear-patterned hydrogel microfibers with aligned submicron topography. The process that the flow-induced shear force reshapes the surface of hydrogel fiber into aligned submicron topography was systematically analysed...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29021705/global-analysis-of-ginsenoside-rg1-protective-effects-in-%C3%AE-amyloid-treated-neuronal-cells
#8
Ji Seon Shim, Min-Young Song, Sung-Vin Yim, Seung-Eun Lee, Kang-Sik Park
BACKGROUND: A number of reports have described the protective effects of ginsenoside Rg1 (Rg1) in Alzheimer's disease (AD). However, the protective mechanisms of Rg1 in AD remain elusive. METHODS: To investigate the potential mechanisms of Rg1 in β-amyloid peptide-treated SH-SY5Y cells, a comparative proteomic analysis was performed using stable isotope labeling with amino acids in cell culture combined with nano-LC-MS/MS. RESULTS: We identified a total of 1,149 proteins in three independent experiments...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28981426/equivalent-circuit-of-the-neuro-electronic-junction-for-signal-recordings-from-planar-and-engulfed-micro-nano-electrodes
#9
Giuseppe Massobrio, Sergio Martinoia, Paolo Massobrio
In the latest years, several attempts to develop extracellular microtransducers to record electrophysiological activity of excitable cells have been done. In particular, many efforts have been oriented to increase the coupling conditions, and, thus, improving the quality of the recorded signal. Gold mushroom-shaped microelectrodes (GMμE) are an example of nano-devices to achieve those requirements. In this study, we developed an equivalent electrical circuit of the neuron-microelectrode system interface to simulate signal recordings from both planar and engulfed micro-nano-electrodes...
October 5, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28962965/effects-of-nanoparticle-encapsulated-curcumin-on-hiv-gp120-associated-neuropathic-pain-induced-by-the-p2x3-receptor-in-dorsal-root-ganglia
#10
Shanhong Zhao, Jinpu Yang, Xinyao Han, Yingxin Gong, Shenqiang Rao, Bing Wu, Zhihua Yi, Lifang Zou, Tianyu Jia, Lin Li, Huilong Yuan, Liran Shi, Chunping Zhang, Yun Gao, Guilin Li, Shuangmei Liu, Hong Xu, Hui Liu, Shangdong Liang
HIV-1 envelope glycoprotein (Glycoprotein 120, gp120) can directly stimulate primary sensory afferent neurons and cause chronic neuropathic pain. The P2X3 receptor in the dorsal root ganglia (DRG) is associated with the transmission of neuropathic pain. Curcumin isolated from the herb Curcuma rhizome has anti-inflammatory and anti-tumor effects. The water solubility, targeting and bioavailability of curcumin can be improved by nanoparticle encapsulation. In this study, we sought to explore the effects of nanoparticle-encapsulated curcumin (nano curcumin) on HIV-gp120-induced neuropathic pain mediated by the P2X3 receptor in DRG neurons...
September 28, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28939873/brain-inflammation-blood-brain-barrier-dysfunction-and-neuronal-synaptophysin-decrease-after-inhalation-exposure-to-titanium-dioxide-nano-aerosol-in-aging-rats
#11
Clémence Disdier, Monique Chalansonnet, François Gagnaire, Laurent Gaté, Frédéric Cosnier, Jérôme Devoy, Wadad Saba, Amie K Lund, Emilie Brun, Aloïse Mabondzo
Notwithstanding potential neurotoxicity of inhaled titanium dioxide nanoparticles (TiO2 NPs), the toxicokinetics and consequences on blood-brain barrier (BBB) function remain poorly characterized. To improve risk assessment, we need to evaluate the impact on BBB under realistic environmental conditions and take into account vulnerability status such as age. 12-13 week and 19-month-old male rats were exposed by inhalation to 10 mg/m(3) of TiO2 nano-aerosol (6 hrs/day, 5 day/week, for 4 weeks). We showed an age-dependent modulation of BBB integrity parameters suggesting increased BBB permeability in aging rats...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28930148/elongation-of-axon-extension-for-human-ipsc-derived-retinal-ganglion-cells-by-a-nano-imprinted-scaffold
#12
Tien-Chun Yang, Jen-Hua Chuang, Waradee Buddhakosai, Wen-Ju Wu, Chen-Ju Lee, Wun-Syuan Chen, Yi-Ping Yang, Ming-Chia Li, Chi-Hsien Peng, Shih-Jen Chen
Optic neuropathies, such as glaucoma and Leber's hereditary optic neuropathy (LHON) lead to retinal ganglion cell (RGC) loss and therefore motivate the application of transplantation technique into disease therapy. However, it is a challenge to direct the transplanted optic nerve axons to the correct location of the retina. The use of appropriate scaffold can promote the proper axon growth. Recently, biocompatible materials have been integrated into the medical field, such as tissue engineering and reconstruction of damaged tissues or organs...
September 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28923702/zinc-oxide-nanoparticles-synthesis-antiseptic-activity-and-toxicity-mechanism
#13
REVIEW
A Król, P Pomastowski, K Rafińska, V Railean-Plugaru, B Buszewski
Zinc oxide (ZnO), as a material with attractive properties, has attracted great interest worldwide, particularly owing to the implementation of the synthesis of nano-sized particles. High luminescent efficiency, a wide band gap (3.36eV), and a large exciton binding energy (60meV) has triggered intense research on the production of nanoparticles using different synthesis methods and on their future applications. ZnO nanomaterials can be used in industry as nano-optical and nano-electrical devices, in food packaging and in medicine as antimicrobial and antitumor agents...
August 26, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28894412/recording-spikes-activity-in-cultured-hippocampal-neurons-using-flexible-or-transparent-graphene-transistors
#14
Farida Veliev, Zheng Han, Dipankar Kalita, Anne Briançon-Marjollet, Vincent Bouchiat, Cécile Delacour
The emergence of nanoelectronics applied to neural interfaces has started few decades ago, and aims to provide new tools for replacing or restoring disabled functions of the nervous systems as well as further understanding the evolution of such complex organization. As the same time, graphene and other 2D materials have offered new possibilities for integrating micro and nano-devices on flexible, transparent, and biocompatible substrates, promising for bio and neuro-electronics. In addition to many bio-suitable features of graphene interface, such as, chemical inertness and anti-corrosive properties, its optical transparency enables multimodal approach of neuronal based systems, the electrical layer being compatible with additional microfluidics and optical manipulation ports...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28891515/a-computational-approach-towards-the-microscale-mouse-brain-connectome-from-the-mesoscale
#15
Tielin Zhang, Yi Zeng, Bo Xu
The wiring diagram of the mouse brain presents an indispensable foundation for the research on basic and applied neurobiology. It is also essential as a structural foundation for computational simulation of the brain. Different scales of the connectome give us different hints and clues to understand the functions of the nervous system and how they process information. However, compared to the macroscale and most recent mesoscale mouse brain connectome studies, there is no complete whole brain microscale connectome available because of the scalability and accuracy of automatic recognition techniques...
2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28877412/neuronal-differentiation-of-human-mesenchymal-stem-cells-in-response-to-the-domain-size-of-graphene-substrates
#16
Yoo-Jung Lee, Tae Hoon Seo, Seul-A Lee, Wonhee Jang, Myung Jong Kim, Jung-Suk Sung
Graphene is a non-cytotoxic monolayer platform with unique physical, chemical, and biological properties. It has been demonstrated that graphene substrate may provide a promising biocompatible scaffold for stem cell therapy. Since chemical vapor deposited graphene has a two dimensional poly-crystalline structure, it is important to control the individual domain size to obtain desirable properties for nano-material. However, the biological effects mediated by differences in domain size of graphene have not yet been reported...
September 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28876356/a-versatile-upconversion-surface-evaluation-platform-for-bio-nano-surface-selection-for-the-nervous-system
#17
Libing Fu, Marco Morsch, Bingyang Shi, Guoying Wang, Albert Lee, Rowan Radford, Yiqing Lu, Dayong Jin, Roger Chung
There is considerable interest in developing diagnostic nanotools for early detection and delivery of various therapeutic agents for treatment of neurodegenerative diseases. However, a key challenge remains in the selection of suitable surfaces to overcome the nano-bio interface issue, namely that many nanoparticle surfaces demonstrate instability when administered into biological environments and show substantial cytotoxicity to the central nervous system. In this study, we fabricated an evaluation platform for bio-nano surface selection based on the combination of upconversion nanoparticles (UCNPs), cultured neural cells and zebra fish, and systemically demonstrated how it can evaluate the suitability of nanoparticle surfaces for applications in the central nervous system...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28830725/a-high-sensitive-nano-modified-biosensor-for-dynamic-monitoring-of-glutamate-and-neural-spike-covariation-from-rat-cortex-to-hippocampal-sub-regions
#18
Guihua Xiao, Yilin Song, Song Zhang, Lili Yang, Shengwei Xu, Yu Zhang, Huiren Xu, Fei Gao, Ziyue Li, Xinxia Cai
BACKGROUND: Hippocampus is a critical part of brain tissue involved in many cognitive neural activities. They are controlled by various neurotransmitters such as glutamate (Glu), and affected by electrophysiology. NEW METHOD: Herein, we fabricated a 16-site (25μm in diameter) microelectrode array (MEA) biosensor applied in dual-mode tests including Glu and neural spike measurements. METHODS: All the 16 recording sites were electrodeposited with platinum nanoparticles (PtNPs) and 8 sites were used for electrical recording...
November 1, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28805664/correlation-and-comparison-of-cortical-and-hippocampal-neural-progenitor-morphology-and-differentiation-through-the-use-of-micro-and-nano-topographies
#19
Sharvari Sathe, Xiang Quan Chan, Jing Jin, Erik Bernitt, Hans-Günther Döbereiner, Evelyn K F Yim
Neuronal morphology and differentiation have been extensively studied on topography. The differentiation potential of neural progenitors has been shown to be influenced by brain region, developmental stage, and time in culture. However, the neurogenecity and morphology of different neural progenitors in response to topography have not been quantitatively compared. In this study, the correlation between the morphology and differentiation of hippocampal and cortical neural progenitor cells was explored. The morphology of differentiated neural progenitors was quantified on an array of topographies...
August 12, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28803044/new-racemic-annulated-pyrazolo-1-2-b-phthalazines-as-tacrine-like-ache-inhibitors-with-potential-use-in-alzheimer-s-disease
#20
Leili Jalili-Baleh, Hamid Nadri, Alireza Moradi, Syed Nasir Abbas Bukhari, Mojtaba Shakibaie, Mandana Jafari, Mostafa Golshani, Farshad Homayouni Moghadam, Loghman Firoozpour, Ali Asadipour, Saeed Emami, Mehdi Khoobi, Alireza Foroumadi
A novel series of tacrine-like compounds 7a-u possessing a fused pyrazolo[1,2-b]phthalazine structure were designed and synthesized as potent and selective inhibitors of AChE. The in-vitro biological assessments demonstrated that several compounds had high anti-AChE activity at nano-molar level. The more promising compound 7l with IC50 of 49 nM was 7-fold more potent than tacrine and unlike tacrine, it was highly selective against AChE over BuChE. The cell-based assays against hepatocytes (HepG2) and neuronal cell line (PC12) revealed that 7l had significantly lower hepatotoxicity compared to tacrine, with additional neuroprotective activity against H2O2-induced damage in PC12 cells...
October 20, 2017: European Journal of Medicinal Chemistry
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