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MULTICENTER STUDY
Celeste M Porsbjerg, John Townend, Celine Bergeron, George C Christoff, Gregory P Katsoulotos, Désirée Larenas-Linnemann, Trung N Tran, Riyad Al-Lehebi, Sinthia Z Bosnic-Anticevich, John Busby, Mark Hew, Konstantinos Kostikas, Nikolaos G Papadopoulos, Paul E Pfeffer, Todor A Popov, Chin Kook Rhee, Mohsen Sadatsafavi, Ming-Ju Tsai, Charlotte Suppli Ulrik, Mona Al-Ahmad, Alan Altraja, Aaron Beastall, Lakmini Bulathsinhala, Victoria Carter, Borja G Cosio, Kirsty Fletton, Susanne Hansen, Liam G Heaney, Richard B Hubbard, Piotr Kuna, Ruth B Murray, Tatsuya Nagano, Laura Pini, Diana Jimena Cano Rosales, Florence Schleich, Michael E Wechsler, Rita Amaral, Arnaud Bourdin, Guy G Brusselle, Wenjia Chen, Li Ping Chung, Eve Denton, Joao A Fonseca, Flavia Hoyte, David J Jackson, Rohit Katial, Bruce J Kirenga, Mariko Siyue Koh, Agnieszka Ławkiedraj, Lauri Lehtimäki, Mei Fong Liew, Bassam Mahboub, Neil Martin, Andrew N Menzies-Gow, Pee Hwee Pang, Andriana I Papaioannou, Pujan H Patel, Luis Perez-De-Llano, Matthew J Peters, Luisa Ricciardi, Bellanid Rodríguez-Cáceres, Ivan Solarte, Tunn Ren Tay, Carlos A Torres-Duque, Eileen Wang, Martina Zappa, John Abisheganaden, Karin Dahl Assing, Richard W Costello, Peter G Gibson, Enrico Heffler, Jorge Máspero, Stefania Nicola, Diahn-Warng Perng Steve, Francesca Puggioni, Sundeep Salvi, Chau-Chyun Sheu, Concetta Sirena, Camille Taillé, Tze Lee Tan, Leif Bjermer, Giorgio Walter Canonica, Takashi Iwanaga, Libardo Jiménez-Maldonado, Christian Taube, Luisa Brussino, David B Price
BACKGROUND: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials. AIM: To elucidate the associations of pre-biologic individual biomarker levels or their combinations with pre-to-post biologic changes in asthma outcomes in real-life. METHODS: This was a registry-based, cohort study using data from 23 countries, which shared data with the International Severe Asthma Registry (May 2017-February 2023)...
2024: Frontiers in Immunology
#2
JOURNAL ARTICLE
Oliver Carlile, Andrew Briggs, Alasdair D Henderson, Ben F C Butler-Cole, John Tazare, Laurie A Tomlinson, Michael Marks, Mark Jit, Liang-Yu Lin, Chris Bates, John Parry, Sebastian C J Bacon, Iain Dillingham, William A Dennison, Ruth E Costello, Alex J Walker, William Hulme, Ben Goldacre, Amir Mehrkar, Brian MacKenna, Emily Herrett, Rosalind M Eggo
BACKGROUND: Long COVID is a major problem affecting patient health, the health service, and the workforce. To optimise the design of future interventions against COVID-19, and to better plan and allocate health resources, it is critical to quantify the health and economic burden of this novel condition. We aimed to evaluate and estimate the differences in health impacts of long COVID across sociodemographic categories and quantify this in Quality-Adjusted Life-Years (QALYs), widely used measures across health systems...
May 2024: The Lancet regional health. Europe
#3
JOURNAL ARTICLE
Christopher W Mastropietro, Peter Sassalos, Christine M Riley, Kurt Piggott, Kiona Y Allen, Elizabeth Prentice, Raya Safa, Jason R Buckley, David K Werho, Martin Wakeham, Arthur Smerling, Andrew R Yates, Ilias Iliopoulos, Hitesh Sandhu, Saurabh Chiwane, Asaad Beshish, David M Kwiatkowski, Saul Flores, Sukumar Suguna Narashimhulu, Rohit Loomba, Christine A Capone, Francis Pike, John M Costello
OBJECTIVES: Multicenter studies reporting outcomes following tracheostomy in children with congenital heart disease are limited, particularly in patients with single ventricle physiology. We aimed to describe clinical characteristics and outcomes in a multicenter cohort of patients with single ventricle physiology who underwent tracheostomy before Fontan operation. DESIGN: Multicenter retrospective cohort study.SETTING: Twenty-one tertiary care pediatric institutions participating in the Collaborative Research from the Pediatric Cardiac Intensive Care Society...
April 29, 2024: Pediatric Critical Care Medicine
#4
JOURNAL ARTICLE
Andrew D Brown, Louis Fisher, Helen J Curtis, Milan Wiedemann, William J Hulme, Victoria Speed, Lisa E M Hopcroft, Christine Cunningham, Ruth E Costello, James B Galloway, Mark D Russell, Katie Bechman, Zeyneb Kurt, Richard Croker, Chris Wood, Alex J Walker, Andrea L Schaffer, Seb C J Bacon, Amir Mehrkar, George Hickman, Chris Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Ben Goldacre, Brian MacKenna
AIMS: The COVID-19 pandemic created unprecedented pressure on healthcare services. This study investigates whether disease-modifying antirheumatic drug (DMARD) safety monitoring was affected during the COVID-19 pandemic. METHODS: A population-based cohort study was conducted using the OpenSAFELY platform to access electronic health record data from 24.2 million patients registered at general practices using TPP's SystmOne software. Patients were included for further analysis if prescribed azathioprine, leflunomide or methotrexate between November 2019 and July 2022...
April 8, 2024: British Journal of Clinical Pharmacology
#5
JOURNAL ARTICLE
Negaar Aryan, Areg Grigorian, Erika Tay-Lasso, Michael Cripps, Heather Carmichael, Robert McIntyre, Shane Urban, Catherine Velopulos, Clay Cothren Burlew, Shana Ballow, Rachel C Dirks, Aimee LaRiccia, Michael S Farrell, Deborah M Stein, Michael S Truitt, Heather M Grossman Verner, Caleb J Mentzer, T J Mack, Chad G Ball, Kaushik Mukherjee, Georgi Mladenov, Daniel J Haase, Hossam Abdou, Thomas J Schroeppel, Jennifer Rodriquez, Miklosh Bala, Natasha Keric, Morgan Crigger, Navpreet K Dhillon, Eric J Ley, Tanya Egodage, John Williamson, Tatiana Cp Cardenas, Vadine Eugene, Kumash Patel, Kristen Costello, Stephanie Bonne, Fatima S Elgammal, Warren Dorlac, Claire Pederson, Nicole L Werner, James M Haan, Kelly Lightwine, Gregory Semon, Kristen Spoor, Laura A Harmon, Jason M Samuels, M C Spalding, Jeffry Nahmias
BACKGROUND: High-grade liver injuries with extravasation (HGLI + Extrav) are associated with morbidity/mortality. For low-grade injuries, an observation (OBS) first-strategy is beneficial over initial angiography (IR), however, it is unclear if OBS is safe for HGLI + Extrav. Therefore, we evaluated the management of HGLI + Extrav patients, hypothesizing IR patients will have decreased rates of operation and mortality...
March 26, 2024: American Journal of Surgery
#6
JOURNAL ARTICLE
Roman O Kowalchuk, Trey C Mullikin, Grant M Spears, Benjamin A Johnson-Tesch, Peter S Rose, Brittany L Siontis, Dong Kun Kim, Brian A Costello, Jonathan M Morris, Robert W Gao, Satomi Shiraishi, John J Lucido, Kenneth R Olivier, Dawn Owen, Bradley J Stish, Mark R Waddle, Nadia N Laack, Sean S Park, Paul D Brown, Kenneth W Merrell
OBJECTIVES: Metastasis-directed stereotactic body radiation therapy (SBRT) has demonstrated robust clinical benefits in carefully selected patients, improving local control and even overall survival (OS). We assess a large database to determine clinical and dosimetric predictors of local failure after spine SBRT. METHODS: Spine SBRT treatments with imaging follow-up were identified. Patients were treated with a simultaneous integrated boost technique using 1 or 3 fractions, delivering 20-24 Gy in 1 fraction to the gross tumor volume (GTV) and 16 Gy to the low dose volume (or 27-36 Gy and 21-24 Gy for 3 fraction treatments)...
March 27, 2024: Radiotherapy and Oncology
#7
COMMENT
Tarah T Colaizy, Brenda B Poindexter, Scott A McDonald, Edward F Bell, Waldemar A Carlo, Susan J Carlson, Sara B DeMauro, Kathleen A Kennedy, Leif D Nelin, Pablo J Sánchez, Betty R Vohr, Karen J Johnson, Dianne E Herron, Abhik Das, Margaret M Crawford, Michele C Walsh, Rosemary D Higgins, Barbara J Stoll, Namisavayam Ambalavanan, Myra H Wyckoff, Carl T D'Angio, George W Bugg, Robin K Ohls, Anne Marie Reynolds, Gregory M Sokol, Abbot R Laptook, Steven L Olsen, Jessica R White, Sudarshan R Jadcherla, Monika Bajaj, Prabhu S Parimi, Barbara Schmidt, Matthew M Laughon, John Barks, Kimberley A Fisher, Anna Maria Hibbs, Myriam Peralta-Carcelen, Noah Cook, Roy J Heyne, Brenna Cavanaugh, Ira Adams-Chapman, Janell Fuller, Michelle E Hartley-McAndrew, Heidi M Harmon, Andrea F Duncan, Abbey C Hines, Howard W Kilbride, Laurie A Richards, Nathalie L Maitre, Girija Natarajan, Andrea N Trembath, Martha D Carlson, William F Malcolm, Deanne E Wilson-Costello
IMPORTANCE: Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared with preterm formula. For infants receiving no or minimal maternal milk, it is unknown whether donor human milk conveys similar neurodevelopmental advantages vs preterm formula. OBJECTIVE: To determine if nutrient-fortified, pasteurized donor human milk improves neurodevelopmental outcomes at 22 to 26 months' corrected age compared with preterm infant formula among extremely preterm infants who received minimal maternal milk...
February 20, 2024: JAMA
#8
JOURNAL ARTICLE
Andreas M Neophytou, Jacqueline M Ferguson, Sadie Costello, Sally Picciotto, John R Balmes, Stella Koutros, Debra T Silverman, Ellen A Eisen
BACKGROUND: Diesel exhaust and respirable dust exposures in the mining industry have not been studied in depth with respect to non-malignant respiratory disease including chronic obstructive pulmonary disease (COPD), with most available evidence coming from other settings. OBJECTIVES: To assess the relationship between occupational diesel exhaust and respirable dust exposures and COPD mortality, while addressing issues of survivor bias in exposed miners. METHODS: The study population consisted of 11,817 male workers from the Diesel Exhaust in Miners Study II, followed from 1947 to 2015, with 279 observed COPD deaths...
February 24, 2024: Environment International
#9
JOURNAL ARTICLE
Tae Yoon Lee, David Price, Chandra Prakash Yadav, Rupsa Roy, Laura Lim Huey Mien, Eileen Wang, Michael E Wechsler, David J Jackson, John Busby, Liam G Heaney, Paul E Pfeffer, Bassam Mahboub, Diahn-Warng Perng Steve, Borja G Cosio, Luis Perez-de-Llano, Riyad Al-Lehebi, Désirée Larenas-Linnemann, Mona Al-Ahmad, Chin Kook Rhee, Takashi Iwanaga, Enrico Heffler, Giorgio Walter Canonica, Richard Costello, Nikolaos G Papadopoulos, Andriana I Papaioannou, Celeste M Porsbjerg, Carlos A Torres-Duque, George C Christoff, Todor A Popov, Mark Hew, Matthew Peters, Peter G Gibson, Jorge Maspero, Celine Bergeron, Saraid Cerda, Elvia Angelica Contreras Contreras, Wenjia Chen, Mohsen Sadatsafavi
BACKGROUND: Exacerbation frequency strongly influences treatment choices in patients with severe asthma. RESEARCH QUESTION: What is the extent of the variability of exacerbations rate across countries and its implications in disease management? STUDY DESIGN AND METHODS: We retrieved data from the International Severe Asthma Registry, an international observational cohort of patients with a clinical diagnosis of severe asthma. We identified patients aged ≥18 years who did not initiate any biologics prior to baseline visit...
February 21, 2024: Chest
#10
JOURNAL ARTICLE
Robert J Motzer, Eric Jonasch, Neeraj Agarwal, Ajjai Alva, Hilary Bagshaw, Michael Baine, Kathryn Beckermann, Maria I Carlo, Toni K Choueiri, Brian A Costello, Ithaar H Derweesh, Arpita Desai, Yasser Ged, Saby George, John L Gore, Andrew Gunn, Naomi Haas, Michael Johnson, Payal Kapur, Jennifer King, Christos Kyriakopoulos, Elaine T Lam, Primo N Lara, Clayton Lau, Bryan Lewis, David C Madoff, Brandon Manley, M Dror Michaelson, Amir Mortazavi, Lee Ponsky, Sundhar Ramalingam, Brian Shuch, Zachary L Smith, Jeffrey Sosman, Randy Sweis, Matthew Zibelman, Ryan Schonfeld, MaryElizabeth Stein, Lisa A Gurski
The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for diagnostic workup, staging, and treatment of patients with renal cell carcinoma (RCC). These NCCN Guidelines Insights focus on the systemic therapy options for patients with advanced RCC and summarize the new clinical data evaluated by the NCCN panel for the recommended therapies in Version 2.2024 of the NCCN Guidelines for Kidney Cancer.
February 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#11
JOURNAL ARTICLE
Orla Woods, Rachel MacDonell, John Brennan, Lucia Prihodova, Breda Cushen, Richard W Costello, Timothy J McDonnell
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the the most common disease-specific cause of adult emergency hospital admissions in Ireland. Preliminary groundwork indicated that treatment of acute exacerbations of COPD (AECOPD) in Ireland is not standardised between public hospitals. Applying Institute for Healthcare Improvement Breakthrough Series and Model for Improvement methodologies, Royal College of Physicians of Ireland designed and conducted a novel flexible and adaptive quality improvement (QI) collaborative which, using embedded evaluation, aimed to deliver QI teaching to enable teams to implement bespoke, locally applicable changes to improve and standardise acute COPD care at presentation, admission and discharge stages within their hospitals...
January 8, 2024: BMJ Open Quality
#12
JOURNAL ARTICLE
Elvis Duran Sierra, Raul Valenzuela, Mathew A Canjirathinkal, Colleen M Costelloe, Heerod Moradi, John E Madewell, William A Murphy, Behrang Amini
PURPOSE: Limitations from commercial software applications prevent the implementation of a robust and cost-efficient high-throughput cancer imaging radiomic feature extraction and perfusion analysis workflow. This study aimed to develop and validate a cancer research computational solution using open-source software for vendor- and sequence-neutral high-throughput image processing and feature extraction. METHODS: The Cancer Radiomic and Perfusion Imaging (CARPI) automated framework is a Python-based software application that is vendor- and sequence-neutral...
January 2024: JCO Clinical Cancer Informatics
#13
JOURNAL ARTICLE
Behrang Amini, Liu Chenglei, Elvis Duran-Sierra, Wei-Lien Wang, Mathew A Canjirathinkal, Heerod Moradi, William N Green, John E Madewell, Collen M Costelloe, William A Murphy, Raul F Valenzuela
PURPOSE: Chondrosarcomas arise from the lateral pelvis; however, midline chondrosarcomas (10%) display similar imaging features to chordoma, causing a diagnostic challenge. This study aims to determine the diagnostic accuracy of apparent diffusion coefficient (ADC)-based radiomic features and two novel diffusion indices for differentiating sacral chordomas and chondrosarcomas. METHODS: A retrospective, multireader review was performed of 82 pelvic MRIs (42 chordomas and 40 chondrosarcomas) between December 2014 and September 2021, split into training (n = 69) and validation (n = 13) data sets...
September 2023: JCO Precision Oncology
#14
JOURNAL ARTICLE
Sara Hadad, Rohit Gupta, Nancy Ann Oberheim Bush, Jennie W Taylor, Javier E Villanueva-Meyer, Jacob S Young, Jasper Wu, Ajay Ravindranathan, Yalan Zhang, Gayathri Warrier, Lucie McCoy, Anny Shai, Melike Pekmezci, Arie Perry, Andrew W Bollen, Joanna J Phillips, Steve E Braunstein, David R Raleigh, Philip Theodosopoulos, Manish K Aghi, Edward F Chang, Shawn L Hervey-Jumper, Joseph F Costello, John de Groot, Nicholas A Butowski, Jennifer L Clarke, Susan M Chang, Mitchel S Berger, Annette M Molinaro, David A Solomon
Glioblastoma is a clinically and molecularly heterogeneous disease, and new predictive biomarkers are needed to identify those patients most likely to respond to specific treatments. Through prospective genomic profiling of 459 consecutive primary treatment-naïve IDH-wildtype glioblastomas in adults, we identified a unique subgroup (2%, 9/459) defined by somatic hypermutation and DNA replication repair deficiency due to biallelic inactivation of a canonical mismatch repair gene. The deleterious mutations in mismatch repair genes were often present in the germline in the heterozygous state with somatic inactivation of the remaining allele, consistent with glioblastomas arising due to underlying Lynch syndrome...
December 11, 2023: Acta Neuropathologica
#15
Jean M Costello, Hannah Takasuka, Jacquelyn Roger, Ophelia Yin, Alice Tang, Tomiko Oskotsky, Marina Sirota, John A Capra
BACKGROUND: Preterm birth (PTB) is the leading cause of infant mortality and follows multiple biological pathways, many of which are poorly understood. Some PTBs result from medically indicated labor following complications from hypertension and/or diabetes, while many others are spontaneous with unknown causes. Previously, investigation of potential risk factors has been limited by lack of data on maternal medical history and the difficulty of classifying PTBs as indicated or spontaneous...
November 30, 2023: medRxiv
#16
JOURNAL ARTICLE
Sabrina Kumschick, Sandro Bertolino, Tim M Blackburn, Giuseppe Brundu, Katie E Costello, Maarten de Groot, Thomas Evans, Belinda Gallardo, Piero Genovesi, Tanushri Govender, Jonathan M Jeschke, Katharina Lapin, John Measey, Ana Novoa, Ana L Nunes, Anna F Probert, Petr Pyšek, Cristina Preda, Wolfgang Rabitsch, Helen E Roy, Kevin G Smith, Elena Tricarico, Montserrat Vilà, Giovanni Vimercati, Sven Bacher
The Environmental Impact Classification for Alien Taxa (EICAT) is an important tool for biological invasion policy and management and has been adopted as an International Union for Conservation of Nature (IUCN) standard to measure the severity of environmental impacts caused by organisms living outside their native ranges. EICAT has already been incorporated into some national and local decision-making procedures, making it a particularly relevant resource for addressing the impact of non-native species. Recently, some of the underlying conceptual principles of EICAT, particularly those related to the use of the precautionary approach, have been challenged...
December 5, 2023: Conservation Biology
#17
JOURNAL ARTICLE
Joseph Weygand, Tess Armstrong, John Michael Bryant, Jacqueline M Andreozzi, Ibrahim M Oraiqat, Steven Nichols, Casey L Liveringhouse, Kujtim Latifi, Kosj Yamoah, James R Costello, Jessica M Frakes, Eduardo G Moros, Issam M El Naqa, Arash O Naghavi, Stephen A Rosenberg, Gage Redler
BACKGROUND AND PURPOSE: Diffusion weighted imaging (DWI) allows for the interrogation of tissue cellularity, which is a surrogate for cellular proliferation. Previous attempts to incorporate DWI into the workflow of a 0.35 T MR-linac (MRL) have lacked quantitative accuracy. In this study, accuracy, repeatability, and geometric precision of apparent diffusion coefficient (ADC) maps produced using an echo planar imaging (EPI)-based DWI protocol on the MRL system is illustrated, and in vivo potential for longitudinal patient imaging is demonstrated...
October 2023: Physics and Imaging in Radiation Oncology
#18
JOURNAL ARTICLE
Michael E Wechsler, Ghislaine Scelo, Désirée E S Larenas-Linnemann, Carlos A Torres-Duque, Jorge Maspero, Trung N Tran, Ruth B Murray, Neil Martin, Andrew N Menzies-Gow, Mark Hew, Matthew J Peters, Peter G Gibson, George C Christoff, Todor A Popov, Andréanne Côté, Celine Bergeron, Delbert Dorscheid, J Mark FitzGerald, Kenneth R Chapman, Louis Philippe Boulet, Mohit Bhutani, Mohsen Sadatsafavi, Libardo Jiménez-Maldonado, Mauricio Duran-Silva, Bellanid Rodriguez, Carlos Andres Celis-Preciado, Diana Jimena Cano-Rosales, Ivan Solarte, Maria Jose Fernandez-Sanchez, Patricia Parada-Tovar, Anna von Bülow, Anne Sofie Bjerrum, Charlotte S Ulrik, Karin Dahl Assing, Linda Makowska Rasmussen, Susanne Hansen, Alan Altraja, Arnaud Bourdin, Camille Taille, Jeremy Charriot, Nicolas Roche, Andriana I Papaioannou, Konstantinos Kostikas, Nikolaos G Papadopoulos, Sundeep Salvi, Deirdre Long, Patrick D Mitchell, Richard Costello, Concetta Sirena, Cristina Cardini, Enrico Heffler, Francesca Puggioni, Giorgio Walter Canonica, Giuseppe Guida, Takashi Iwanaga, Mona Al-Ahmad, Ulises García, Piotr Kuna, João A Fonseca, Riyad Al-Lehebi, Mariko S Koh, Chin Kook Rhee, Borja G Cosio, Luis Perez de Llano, Diahn-Warng Steve Perng, Erick Wan-Chun Huang, Hao-Chien Wang, Ming-Ju Tsai, Bassam Mahboub, Laila Ibraheem Jaber Salameh, David J Jackson, John Busby, Liam G Heaney, Paul E Pfeffer, Amanda Grippen Goddard, Eileen Wang, Flavia C L Hoyte, Nicholas M Chapman, Rohit Katial, Victoria Carter, Lakmini Bulathsinhala, Neva Eleangovan, Con Ariti, Juntao Lyu, Celeste Porsbjerg, David B Price
Rationale: Previous studies investigating the impact of comorbidities on the effectiveness of biologic agents have been relatively small and of short duration and have not compared classes of biologic agents. Objectives: To determine the association between type 2-related comorbidities and biologic agent effectiveness in adults with severe asthma (SA). Methods: This cohort study used International Severe Asthma Registry data from 21 countries (2017-2022) to quantify changes in four outcomes before and after biologic therapy-annual asthma exacerbation rate, FEV1 % predicted, asthma control, and long-term oral corticosteroid daily dose-in patients with or without allergic rhinitis, chronic rhinosinusitis (CRS) with or without nasal polyps (NPs), NPs, or eczema/atopic dermatitis...
February 1, 2024: American Journal of Respiratory and Critical Care Medicine
#19
JOURNAL ARTICLE
John B Ingraham, Max Baranov, Zak Costello, Karl W Barber, Wujie Wang, Ahmed Ismail, Vincent Frappier, Dana M Lord, Christopher Ng-Thow-Hing, Erik R Van Vlack, Shan Tie, Vincent Xue, Sarah C Cowles, Alan Leung, João V Rodrigues, Claudio L Morales-Perez, Alex M Ayoub, Robin Green, Katherine Puentes, Frank Oplinger, Nishant V Panwar, Fritz Obermeyer, Adam R Root, Andrew L Beam, Frank J Poelwijk, Gevorg Grigoryan
Three billion years of evolution has produced a tremendous diversity of protein molecules1 , but the full potential of proteins is likely to be much greater. Accessing this potential has been challenging for both computation and experiments because the space of possible protein molecules is much larger than the space of those likely to have functions. Here we introduce Chroma, a generative model for proteins and protein complexes that can directly sample novel protein structures and sequences, and that can be conditioned to steer the generative process towards desired properties and functions...
November 15, 2023: Nature
#20
JOURNAL ARTICLE
Bang Zheng, John Tazare, Linda Nab, Amelia Ca Green, Helen J Curtis, Viyaasan Mahalingasivam, Emily L Herrett, Ruth E Costello, Rosalind M Eggo, Victoria Speed, Sebastian Cj Bacon, Christopher Bates, John Parry, Jonathan Cockburn, Frank Hester, Sam Harper, Andrea L Schaffer, William J Hulme, Amir Mehrkar, Stephen Jw Evans, Brian MacKenna, Ben Goldacre, Ian J Douglas, Laurie A Tomlinson
BACKGROUND: Timely evidence of the comparative effectiveness between COVID-19 therapies in real-world settings is needed to inform clinical care. This study aimed to compare the effectiveness of nirmatrelvir/ritonavir versus sotrovimab and molnupiravir in preventing severe COVID-19 outcomes in non-hospitalised high-risk COVID-19 adult patients during Omicron waves. METHODS: With the approval of NHS England, we conducted a real-world cohort study using the OpenSAFELY-TPP platform...
November 2023: The Lancet regional health. Europe
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