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John M Costello

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https://www.readbyqxmd.com/read/27893535/cytoplasmic-hur-status-predicts-disease-free-survival-in-resected-pancreatic-cancer-a-post-hoc-analysis-from-the-international-phase-iii-espac-3-clinical-trial
#1
Talar Tatarian, Wei Jiang, Benjamin E Leiby, Amanda Grigoli, Masaya Jimbo, Nooreen Dabbish, John P Neoptolemos, William Greenhalf, Eithne Costello, Paula Ghaneh, Christopher Halloran, Daniel Palmer, Markus Buchler, Charles J Yeo, Jordan M Winter, Jonathan R Brody
OBJECTIVES: We tested cytoplasmic HuR (cHuR) as a predictive marker for response to chemotherapy by examining tumor samples from the international European Study Group of Pancreatic Cancer-3 trial, in which patients with resected pancreatic ductal adenocarcinoma (PDA) received either gemcitabine (GEM) or 5-fluorouracil (5-FU) adjuvant monotherapy. BACKGROUND: Previous studies have implicated the mRNA-binding protein, HuR (ELAVL1), as a predictive marker for PDA treatment response in the adjuvant setting...
November 23, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27826709/risk-factors-for-cardiac-arrest-or-mechanical-circulatory-support-in-children-with-fulminant-myocarditis
#2
Joseph R Casadonte, Mjaye L Mazwi, Katheryn E Gambetta, Hannah L Palac, Mary E McBride, Osama M Eltayeb, Michael C Monge, Carl L Backer, John M Costello
In children with fulminant myocarditis (FM), we sought to describe presenting characteristics and clinical outcomes, and identify risk factors for cardiac arrest and mechanical circulatory support (MCS). A retrospective review of patients with FM admitted at our institution between January 1, 2004, and June 31, 2015, was performed. We compared characteristics and outcomes of FM patients who received cardiopulmonary resuscitation (CPR) and/or were placed on MCS (CPR/MCS group) to those who did not develop these outcomes (Control group)...
November 8, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27796362/reconstituted-b-cell-receptor-signaling-reveals-carbohydrate-dependent-mode-of-activation
#3
Rina F Villar, Jinal Patel, Grant C Weaver, Masaru Kanekiyo, Adam K Wheatley, Hadi M Yassine, Catherine E Costello, Kevin B Chandler, Patrick M McTamney, Gary J Nabel, Adrian B McDermott, John R Mascola, Steven A Carr, Daniel Lingwood
Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B cell receptor (BCR) activation modality that proceeded through non-cognate interactions with antigen. Using a new approach to reconstitute antigen-receptor interactions in a human reporter B cell line, we found that sequence-defined BCRs from the human germline repertoire could be triggered by both complementarity to influenza HA and a separate mode of signaling that relied on multivalent ligation of BCR sialyl-oligosaccharide...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27768182/association-of-distinct-mutational-signatures-with-correlates-of-increased-immune-activity-in-pancreatic-ductal-adenocarcinoma
#4
Ashton A Connor, Robert E Denroche, Gun Ho Jang, Lee Timms, Sangeetha N Kalimuthu, Iris Selander, Treasa McPherson, Gavin W Wilson, Michelle A Chan-Seng-Yue, Ivan Borozan, Vincent Ferretti, Robert C Grant, Ilinca M Lungu, Eithne Costello, William Greenhalf, Daniel Palmer, Paula Ghaneh, John P Neoptolemos, Markus Buchler, Gloria Petersen, Sarah Thayer, Michael A Hollingsworth, Alana Sherker, Daniel Durocher, Neesha Dhani, David Hedley, Stefano Serra, Aaron Pollett, Michael H A Roehrl, Prashant Bavi, John M S Bartlett, Sean Cleary, Julie M Wilson, Ludmil B Alexandrov, Malcolm Moore, Bradly G Wouters, John D McPherson, Faiyaz Notta, Lincoln D Stein, Steven Gallinger
Importance: Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain poor. Advances in next-generation sequencing provide a route to therapeutic approaches, and integrating DNA and RNA analysis with clinicopathologic data may be a crucial step toward personalized treatment strategies for this disease. Objective: To classify PDAC according to distinct mutational processes, and explore their clinical significance. Design, Setting, and Participants: We performed a retrospective cohort study of resected PDAC, using cases collected between 2008 and 2015 as part of the International Cancer Genome Consortium...
October 20, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27714914/a-pilot-study-of-potential-brain-donor-satisfaction-and-attitudes-towards-telephone-assessment
#5
Helen Costello, Gillian M Hayes, Elizabeth Highton-Williamson, Shirley Nurock, Dave Hanbury, Paul T Francis
OBJECTIVE: Test the feasibility of assessing cognition, psychiatric symptoms and daily living skills of potential brain donors by telephone and compare satisfaction and attitudes across telephone and face-to-face assessment. METHOD: Data were collected from 108 healthy participants from the Brains for Dementia Research cohort. Purposive sampling was used to assess feasibility and a randomised control trial design compared satisfaction and attitudes towards telephone and face-to-face assessment...
October 7, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27671144/radical-nephrectomy-with-or-without-lymph-node-dissection-for-nonmetastatic-renal-cell-carcinoma-a-propensity-score-based-analysis
#6
Boris Gershman, R Houston Thompson, Daniel M Moreira, Stephen A Boorjian, Matthew K Tollefson, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
BACKGROUND: It is uncertain whether lymph node dissection (LND) provides a therapeutic benefit in renal cell carcinoma (RCC). OBJECTIVE: To evaluate the association of LND with oncologic outcomes among patients undergoing radical nephrectomy (RN) for nonmetastatic RCC. DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort study of 1797 patients treated with RN for M0 RCC between 1990 and 2010, including 606 (34%) who underwent LND. INTERVENTION: RN with or without LND...
September 23, 2016: European Urology
https://www.readbyqxmd.com/read/27663461/lymph-node-dissection-is-not-associated-with-improved-survival-among-patients-undergoing-cytoreductive-nephrectomy-for-metastatic-renal-cell-carcinoma-a-propensity-score-based-analysis
#7
Boris Gershman, R Houston Thompson, Daniel M Moreira, Stephen A Boorjian, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
PURPOSE: The oncologic benefit of lymph node dissection for patients undergoing cytoreductive nephrectomy for metastatic renal cell carcinoma is uncertain. Therefore, we evaluated the association of lymph node dissection with oncologic outcomes among patients undergoing cytoreductive nephrectomy. MATERIALS AND METHODS: We identified 305 patients treated with cytoreductive nephrectomy for metastatic renal cell carcinoma between 1990 and 2010, of whom 188 (62%) underwent lymph node dissection...
September 20, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27625333/extracorporeal-membrane-oxygenation-outcomes-in-children-with-hemophagocytic-lymphohistiocytosis
#8
Katherine Cashen, Roland L Chu, Justin Klein, Peter T Rycus, John M Costello
INTRODUCTION: Pediatric patients with hemophagocytic lymphohistiocytosis (HLH) may develop refractory respiratory or cardiac failure that warrants consideration for extracorporeal membrane oxygenation (ECMO) support. The purposes of this study were to describe the use and outcomes of ECMO in pediatric HLH patients, to identify risk factors for hospital mortality and to compare their ECMO use and outcomes to the ECMO population as a whole. METHODS: Pediatric patients (⩽ 18 years) with a diagnosis of HLH in the Extracorporeal Life Support Organization (ELSO) Registry were included...
September 13, 2016: Perfusion
https://www.readbyqxmd.com/read/27584663/the-impact-of-diabetes-mellitus-on-survival-following-resection-and-adjuvant-chemotherapy-for-pancreatic-cancer
#9
Jörg Kleeff, Eithne Costello, Richard Jackson, Chris Halloran, William Greenhalf, Paula Ghaneh, Richard F Lamb, Markus M Lerch, Julia Mayerle, Daniel Palmer, Trevor Cox, Charlotte L Rawcliffe, Oliver Strobel, Markus W Büchler, John P Neoptolemos
BACKGROUND: Diabetes mellitus is frequently observed in pancreatic cancer patients and is both a risk factor and an early manifestation of the disease. METHODS: We analysed the prognostic impact of diabetes on the outcome of pancreatic cancer following resection and adjuvant chemotherapy using individual patient data from three European Study Group for Pancreatic Cancer randomised controlled trials. Analyses were carried out to assess the association between clinical characteristics and the presence of preoperative diabetes, as well as the effect of diabetic status on overall survival...
September 27, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27544035/complications-and-outcomes-associated-with-surgical-management-of-renal-cell-carcinoma-involving-the-liver-a-matched-cohort-study
#10
Daniel D Joyce, Sarah P Psutka, Ryan T Groeschl, R Houston Thompson, Stephen A Boorjian, John C Cheville, Suzanne B Stewart-Merrill, Christine M Lohse, Brian A Costello, Florencia G Que, Bradley C Leibovich
OBJECTIVES: To assess the safety and utility of more aggressive surgical resection of renal cell carcinoma (RCC) involving the liver at the time of nephrectomy. METHODS: We identified 34 cases at our institution where patients underwent simultaneous nephrectomy and hepatic resection for direct hepatic invasion (n=17) or metastatic RCC (n=21). Perioperative outcomes and complication rates were compared to a matched referent cohort (n=68) undergoing simultaneous nephrectomy and resection of non-hepatic locally invasive/metastatic disease...
August 17, 2016: Urology
https://www.readbyqxmd.com/read/27505182/rescue-of-premature-coronal-suture-fusion-with-tgf-%C3%AE-2-neutralizing-antibody-in-rabbits-with-delayed-onset-synostosis
#11
Mark P Mooney, Jocelyn M Shand, Anne Burrows, Timothy D Smith, John F Caccamese, Gregory M Cooper, James J Cray, James Gilbert, Bernard J Costello, Joseph E Losee, Amr M Moursi, Michael I Siegel
OBJECTIVES:   An overexpression of Tgf-β2 leads to calvarial hyperostosis and suture fusion in individuals with craniosynostosis. Inhibition of Tgf-β2 may help rescue fusing sutures and restore normal growth. The present study was designed to test this hypothesis. DESIGN:   Twenty-eight New Zealand White rabbits with delayed-onset coronal synostosis had radiopaque markers placed on either side of the coronal sutures at 10 days of age. The rabbits were randomly assigned to: (1) sham control rabbits (n = 10), (2) rabbits with control IgG (100 μg/suture) delivered in a collagen vehicle (n = 9), and (3) rabbits with Tgf-β2 neutralizing antibody (100 μg/suture) delivered in a collagen vehicle (n = 9)...
August 9, 2016: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/27490614/shunt-lesions-part-i-patent-ductus-arteriosus-atrial-septal-defect-ventricular-septal-defect-and-atrioventricular-septal-defect
#12
Carl L Backer, Osama Eltayeb, Michael C Mongé, Mjaye L Mazwi, John M Costello
OBJECTIVES: This review summarizes the current understanding of the pathophysiology and perioperative management of patent ductus arteriosus, atrial septal defect, ventricular septal defect, and atrioventricular septal defect. DATA SOURCE: MEDLINE and PubMed. CONCLUSIONS: The four congenital cardiac lesions that are the subject of this review, patent ductus arteriosus, atrial septal defect, ventricular septal defect, and atrioventricular septal defect, are the most commonly found defects causing a left-to-right shunt...
August 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27490608/fluid-management-pharmacologic-and-renal-replacement-therapies
#13
Eric L Wald, Gal Finer, Mary E McBride, Nguyenvu Nguyen, John M Costello, Conrad L Epting
OBJECTIVES: Focusing on critically ill children with cardiac disease, we will review common causes of fluid perturbations, clinical recognition, and strategies to minimize and treat fluid-related complications. DATA SOURCE: MEDLINE and PubMed. CONCLUSIONS: Meticulous fluid management is vital in critically ill children with cardiac disease. Fluid therapy is important to maintain adequate blood volume and perfusion pressure in order to support cardiac output, tissue perfusion, and oxygen delivery...
August 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27489013/renal-fossa-recurrence-following-nephrectomy-for-renal-cell-carcinoma-prognostic-features-and-oncologic-outcomes
#14
Sarah P Psutka, Mark Heidenreich, Stephen A Boorjian, George C Bailey, John C Cheville, Suzanne B Stewart-Merrill, Christine M Lohse, Thomas D Atwell, Brian A Costello, Bradley C Leibovich, R Houston Thompson
OBJECTIVE: To describe clinicopathologic features associated with increased risk of renal fossa recurrences (RFR) following radical nephrectomy (RN) and to describe prognostic features associated with cancer-specific survival (CSS) among patients with RFR treated with primarily locally-directed therapy, systemically directed therapy, or expectant management. PATIENTS AND METHODS: Records of 2502 patients treated with RN for unilateral, sporadic, localized RCC between 1970 and 2006 were reviewed...
August 4, 2016: BJU International
https://www.readbyqxmd.com/read/27453217/concordance-of-pathologic-features-between-metastatic-sites-and-the-primary-tumor-in-surgically-resected-metastatic-renal-cell-carcinoma
#15
Sarah P Psutka, John C Cheville, Brian A Costello, Suzanne B Stewart-Merrill, Christine M Lohse, Bradley C Leibovich, Stephen A Boorjian, R Houston Thompson
OBJECTIVE: To evaluate the concordance of pathologic features in metastatic renal cell carcinoma (RCC) between the primary nephrectomy and metastasectomy specimens. METHODS: Primary nephrectomy (n = 454) and matched metastasectomy specimens (n = 680) from patients treated between 1970 and 2009 for RCC were re-reviewed by 1 urologic pathologist in a blinded fashion. RCC histologic subtype, grade, coagulative necrosis, and the presence of sarcomatoid differentiation were compared between the primary and the metastatic tumor with kappa statistics...
October 2016: Urology
https://www.readbyqxmd.com/read/27358535/intracardiac-tumor-causing-left-ventricular-outflow-tract-obstruction-in-a-newborn
#16
Christopher P Jordan, John P Costello, Kendal M Endicott, Christine Reyes, Thomas J Hougen, Susan D Cummings, Dilip S Nath
The following report describes the case of newborn girl with an asymptomatic systolic murmur, which on imaging revealed a nearly obstructive mass in the left-ventricular outflow tract. The mass was resected and found to be consistent with a rhabdomyoma. Here, we describe the pathologic and clinical characteristics of this tumor.
July 2016: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/27319986/prevalence-of-noncardiac-and-genetic-abnormalities-in-neonates-undergoing-cardiac-operations-analysis-of-the-society-of-thoracic-surgeons-congenital-heart-surgery-database
#17
Angira Patel, John M Costello, Carl L Backer, Sara K Pasquali, Kevin D Hill, Amelia S Wallace, Jeffrey P Jacobs, Marshall L Jacobs
BACKGROUND: Among patients with congenital heart disease (CHD), the coexistence of noncardiac congenital anatomic abnormalities (NC), genetic abnormalities (GA), and syndromes (S) may influence therapeutic strategies and outcomes. The appreciated prevalence of these abnormalities has risen because increased screening and improved diagnostic precision enable identification of these comorbidities in a larger fraction of neonates with CHD. We examined the contemporary prevalence and distribution of NC/GA/S across diagnostic groups among neonates undergoing cardiac operations using a large nationally representative clinical registry...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27240450/novel-modifications-of-a-ventricular-assist-device-for-infants-and-children
#18
Michael C Mongé, Bradley T Kulat, Osama Eltayeb, Shyamasundar Balasubramanya, Anne E Sarwark, Neale R Zingle, Steven T Moss, Michael Alice Moga, Jeffrey G Gossett, Elfriede Pahl, John M Costello, Carl L Backer
BACKGROUND: A continuous-flow "adult" ventricular assist device (VAD) was modified to support infants and children waiting for heart transplantation. METHODS: A centrifugal VAD, designed to flow at 1.5 to 8 L/min, was used as a bridge to transplantation in pediatric patients. In smaller children and infants, a modified recirculation shunt permitted lower flow ranges. In hypoxic patients, an oxygenator was spliced into the circuit. RESULTS: From 2010 to 2015, the VAD was placed in 13 consecutive patients...
July 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27216198/early-epigenetic-downregulation-of-microrna-192-expression-promotes-pancreatic-cancer-progression
#19
Sandeep K Botla, Soniya Savant, Pouria Jandaghi, Andrea S Bauer, Oliver Mücke, Evgeny A Moskalev, John P Neoptolemos, Eithne Costello, William Greenhalf, Aldo Scarpa, Matthias M Gaida, Markus W Büchler, Oliver Strobel, Thilo Hackert, Nathalia A Giese, Hellmut G Augustin, Jörg D Hoheisel
Pancreatic ductal adenocarcinoma (PDAC) is characterized by very early metastasis, suggesting the hypothesis that metastasis-associated changes may occur prior to actual tumor formation. In this study, we identified miR-192 as an epigenetically regulated suppressor gene with predictive value in this disease. miR-192 was downregulated by promoter methylation in both PDAC and chronic pancreatitis, the latter of which is a major risk factor for the development of PDAC. Functional studies in vitro and in vivo in mouse models of PDAC showed that overexpression of miR-192 was sufficient to reduce cell proliferation and invasion...
July 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27112649/repair-of-partial-atrioventricular-septal-defect-age-and-outcomes
#20
Paul J Devlin, Carl L Backer, Osama Eltayeb, Michael C Mongé, Amanda L Hauck, John M Costello
BACKGROUND: We evaluated the outcomes of patients undergoing surgical repair of partial atrioventricular septal defect (AVSD) and analyzed the effect of age on outcome. METHODS: In this single-center retrospective study, we included all children who underwent repair of partial AVSD between 1990 and 2014. We divided the patients into 4 age quartiles (first quartile: 0-0.75 years, n = 22; second quartile: 0.75-1.5 years, n = 21; third quartile: 1.5-3.75 years, n = 22; and fourth quartile: >3...
July 2016: Annals of Thoracic Surgery
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