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Acceptance based therapy

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https://www.readbyqxmd.com/read/28436941/insr-gene-polymorphisms-correlate-with-sensitivity-to-platinum-based-chemotherapy-and-prognosis-in-patients-with-epithelial-ovarian-cancer
#1
J-L Hu, X-L Hu, Q Han, A-Y Guo, C-J Wang, Y-Y Wen, S-D Cang
This study aimed to investigate the correlation between INSR gene polymorphisms on platinum-based chemotherapy sensitivity and prognosis in epithelial ovarian cancer (EOC). A total of 339 EOC patients receiving postoperative chemotherapy were recruited for the study. Tag single nucleotide polymorphism (tag SNP) of INSR gene was screened from HapMap combined with available literature. Frequency distribution of genotypes and alleles in INSR gene was sequenced by ABI3100-Avant. Compared with CC+GC genotype, INSR rs2252673 GG genotype and rs3745546 CC genotype showed less platinum-based chemotherapy sensitivity in EOC patients (OR=0...
April 24, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28436445/cortical-thickness-and-subcortical-gray-matter-volume-in-pediatric-anxiety-disorders
#2
Andrea L Gold, Elizabeth R Steuber, Lauren K White, Jennifer Pacheco, Jessica F Sachs, David Pagliaccio, Erin Berman, Ellen Leibenluft, Daniel S Pine
Perturbations in the prefrontal cortex (PFC), hippocampus, and amygdala are implicated in the development of anxiety disorders. However, most structural neuroimaging studies of patients with anxiety disorders utilize adult samples, and the few studies in youths examine small samples, primarily with volume-based measures. This study tested the hypothesis that cortical thickness of PFC regions and gray matter volume of the hippocampus and amygdala differ between pediatric anxiety disorder patients and healthy volunteers (HVs)...
April 24, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28435280/high-adherence-to-therapy-and-low-cardiac-mortality-and-morbidity-in-patients-after-acute-coronary-syndrome-systematically-managed-by-office-based-cardiologists-in-germany-1-year-outcomes-of-the-proacor-study
#3
Franz Goss, Johannes Brachmann, Christian W Hamm, Winfried Haerer, Nicolaus Reifart, Benny Levenson
We aimed to assess patient acceptance and effectiveness of a 12-month structured management program in patients after an acute coronary syndrome (ACS) event who were treated in a special setting of office-based cardiologists. The program comprised patient documentation with a specific tool (Bundesverband Niedergelassener Kardiologen [German Federation of Office-Based Cardiologists] cardiac pass with visit scheduling) shared by the hospital physician and the office-based cardiologist, the definition of individual treatment targets, and the systematic information of patients in order to optimize adherence to therapy...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28434942/ipsc-derived-regulatory-dendritic-cells-inhibit-allograft-rejection-by%C3%A2-generating-alloantigen-specific-regulatory-t-cells
#4
Songjie Cai, Jiangang Hou, Masayuki Fujino, Qi Zhang, Naotsugu Ichimaru, Shiro Takahara, Ryoko Araki, Lina Lu, Ji-Mei Chen, Jian Zhuang, Ping Zhu, Xiao-Kang Li
Regulatory dendritic cell (DCregs)-based immunotherapy is a potential therapeutic tool for transplant rejection. We generated DCregs from murine induced pluripotent stem cells (iPSCs), which could remain in a "stable immature stage" even under strong stimulation. Harnessing this characteristic, we hypothesized that iPS-DCregs worked as a negative vaccine to generate regulatory T cells (Tregs), and induced donor-specific allograft acceptance. We immunized naive CBA (H-2K(k)) mice with B6 (H-2K(b)) iPS-DCregs and found that Tregs (CD4(+)CD25(+)FOXP3(+)) significantly increased in CBA splenocytes...
April 18, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28434469/the-north-american-yoga-therapy-workforce-survey
#5
Marlysa Sullivan, Matthew Leach, James Snow, Steffany Moonaz
OBJECTIVE: To describe the personal, professional, practice, service and consumer characteristics of the North American yoga therapy workforce. DESIGN: Cross-sectional, descriptive survey developed and informed by the contemporary workforce literature. A link to the e-survey was distributed to members of the International Association of Yoga Therapists. RESULTS: 367 members responded (∼20% of eligible participants). Most were aged 40-69 years (88%) and female (91%)...
April 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28431609/benefit-risk-perception-of-natalizumab-therapy-in-neurologists-and-a-large-cohort-of-multiple-sclerosis-patients
#6
Christoph Heesen, Ingo Kleiter, Sven G Meuth, Julia Krämer, Jürgen Kasper, Sascha Köpke, Wolfgang Gaissmaier
BACKGROUND: Natalizumab (NAT) is associated with the risk of progressive multifocal leukoencephalopathy (PML). Risk stratification algorithms have been developed, however, without detectable reduction of PML incidence. OBJECTIVE: To evaluate to which extent patients and physicians understand and accept risks associated with NAT treatment. METHODS: Prospective observational cohort study in German MS centers (n=73) among NAT-treated MS patients (n=801) and their neurologists (n=99)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28430015/a-randomized-controlled-trial-of-a-mindfulness-and-acceptance-group-therapy-for-residential-substance-use-patients
#7
Ryan C Shorey, Joanna Elmquist, Michael J Gawrysiak, Catherine Strauss, Ellen Haynes, Scott Anderson, Gregory L Stuart
BACKGROUND: Substance use disorders are understood as a chronically relapsing condition that is difficult to treat. However, in recent years there have been promising developments in the treatment of substance use disorders, specifically with interventions based on mindfulness and acceptance and commitment therapy. Little research has examined whether these types of interventions may positively impact residential substance use treatment outcomes. OBJECTIVES: Thus, in the current study we developed and examined, in a randomized controlled trial, a 4-week, eight-session, adjunctive mindfulness and acceptance group therapy for patients in residential substance use treatment...
April 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28428049/stem-cells-for-retinal-disease-a-perspective-on-the-promise-and-perils
#8
Rajesh C Rao, Vaidehi S Dedania, Mark W Johnson
PURPOSE: To summarize key concepts, and early safety and efficacy signals from clinical trials for stem/progenitor cell-based interventions for retinal disease. DESIGN: Interpretive essay. METHODS: Review and synthesis of selected recent reports of stem/progenitor cell-based approaches for retinal disease, with interpretation and perspective. RESULTS: Stem/progenitor cell-based interventions represent a novel class of potential therapies for retinal diseases, such as age-related macular degeneration, inherited retinal dystrophies, and others...
April 17, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28426287/pregnancy-and-the-acceptability-of-computer-based-versus-traditional-mental-health-treatments
#9
Liisa Hantsoo, Jessica Podcasy, Mary Sammel, Cynthia Neill Epperson, Deborah R Kim
BACKGROUND: Recent recommendations urge increased depression screening in pregnant and postpartum women, potentially increasing demand for treatment. Computer-based psychotherapy treatments may address some of perinatal women's unique mental health treatment needs and barriers. MATERIALS AND METHODS: We conducted a quantitative survey of pregnant women (≥12 weeks of gestation) on preferences regarding computer-based therapies compared with traditional therapies (psychotherapy and medication)...
April 20, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28426253/using-computerized-mental-health-programs-in-alternative-education-understanding-the-requirements-of-students-and-staff
#10
Tuuli Kuosmanen, Theresa M Fleming, Margaret M Barry
Computerized cognitive behavioral therapy (cCBT) programs have been shown to be both acceptable and effective with youth. However, their use with more vulnerable youth, such as early school leavers, remains relatively unstudied. This study explored student and staff attitudes toward the use of cCBT in an alternative education setting. METHODS: Student and staff needs were assessed using the Requirements development approach (Van Velsen, Wentzel, & Van Gemert-Pijnen, 2013). An online staff survey (n = 16) was conducted to provide information on the context of delivery, and stakeholder requirements were further explored in four student workshops (n = 32) and staff group discussions (n = 12)...
April 20, 2017: Health Communication
https://www.readbyqxmd.com/read/28422867/a-simple-scoring-algorithm-predicting-extended-spectrum-%C3%AE-lactamase-producers-in-adults-with-community-onset-monomicrobial-enterobacteriaceae-bacteremia-matters-of-frequent-emergency-department-users
#11
Chung-Hsun Lee, Feng-Yuan Chu, Chih-Chia Hsieh, Ming-Yuan Hong, Chih-Hsien Chi, Wen-Chien Ko, Ching-Chi Lee
The incidence of community-onset bacteremia caused by extended-spectrum-β-lactamase (ESBL) producers is increasing. The adverse effects of ESBL production on patient outcome have been recognized and this antimicrobial resistance has significant implications in the delay of appropriate therapy. However, a simple scoring algorithm that can easily, inexpensively, and accurately be applied to clinical settings was lacking. Thus, we established a predictive scoring algorithm for identifying patients at the risk of ESBL-producer infections among patients with community-onset monomicrobial Enterobacteriaceae bacteremia (CoMEB)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422406/comparability-of-three-output-prediction-models-for-a-compact-passively-double-scattered-proton-therapy-system
#12
Sven Ferguson, Yong Chen, Clara Ferreira, Mohammad Islam, Vance P Keeling, Andy Lau, Salahuddin Ahmad, Hosang Jin
The purpose of this study was to investigate comparability of three output prediction models for a compact double-scattered proton therapy system. Two published output prediction models are commissioned for our Mevion S250 proton therapy system. Model A is a correction-based model (Sahoo et al., Med Phys, 2008;35(11):5088-5097) and model B is an analytical model which employs a function of r = (R'-M')/M' (Kooy et al., Phys Med Biol, 2005;50:5487-5456) where R' is defined as depth of distal 100% dose with straggling and M' is the width between distal 100% dose and proximal 100% dose with straggling instead of the theoretical definition due to more accurate output prediction...
April 19, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28421012/moderated-online-social-therapy-a-model-for-reducing-stress-in-carers-of-young-people-diagnosed-with-mental-health-disorders
#13
John Gleeson, Reeva Lederman, Peter Koval, Greg Wadley, Sarah Bendall, Sue Cotton, Helen Herrman, Kingsley Crisp, Mario Alvarez-Jimenez
Family members caring for a young person diagnosed with the onset of mental health problems face heightened stress, depression, and social isolation. Despite evidence for the effectiveness of family based interventions, sustaining access to specialist family interventions is a major challenge. The availability of the Internet provides possibilities to expand and sustain access to evidence-based psychoeducation and personal support for family members. In this paper we describe the therapeutic model and the components of our purpose-built moderated online social therapy (MOST) program for families...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28420262/impact-of-an-educational-intervention-to-improve-physician-adherence-to-bronchiolitis-clinical-practice-guidelines-a-pre-post-intervention-study
#14
Marquita C Genies, Julia M Kim, Kristina Pyclik, Suzanne Rossi, Natalie Spicyn, Janet R Serwint
Bronchiolitis is the leading cause of infant hospitalizations in the United States. Despite clinical practice guidelines discouraging the utilization of non-evidence-based therapies, there continues to be wide variation in care and resource utilization. A pre-post physician focused educational intervention was conducted with the aims to reduce the use of non-evidence-based medical therapies, including bronchodilators, among patients admitted for bronchiolitis. Among patients meeting inclusion criteria (pre: n = 45; post: n = 47), bronchodilator use decreased by 50% ( P < ...
April 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28420227/efficacy-and-tolerability-of-a-plant-based-multi-component-cream-ginetrox%C3%A2-in-vulvovaginal-disorders-of-the-genitourinary-syndrome-during-menopause
#15
Roberto Marrai, Giovanni Lissi, Stefano Togni, Giada Maramaldi, Marco Barbara, Luca Giacomelli
BACKGROUND: Genitourinary syndrome of menopause (GSM) is a symptomatic condition including vaginal dryness, irritation, dyspareunia and recurrent urinary tract infections which affects 40-54% of post-menopausal women. Although several estrogen-based therapies are available, it is generally preferable to avoid hormonal therapy, particularly in women with mild symptoms or at risk for estrogen-responsive neoplasia. Therefore, the most common treatment options are over-the-counter vaginal creams for symptomatic relief...
June 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28419170/evaluation-of-the-relative-efficacy-of-a-couple-cognitive-behaviour-therapy-cbt-for-premenstrual-disorders-pmds-in-comparison-to-one-to-one-cbt-and-a-wait-list-control-a-randomized-controlled-trial
#16
Jane M Ussher, Janette Perz
DESIGN: A randomised control trial (RCT) was conducted to examine the efficacy of couple-based cognitive behaviour therapy (CBT) for Premenstrual Disorders (PMDs), in comparison to one-to-one CBT and a wait-list control. METHODS: Triangulation of quantitative and qualitative outcome measures evaluated changes pre-post intervention. Eighty three women were randomly allocated across three conditions, with 63 completing post-intervention measures, a retention rate of 76%...
2017: PloS One
https://www.readbyqxmd.com/read/28418777/er-la-opioid-rems-and-accredited-education-survey-results-provide-insight-into-clinical-roles-educational-needs-and-learner-preferences
#17
Cynthia Kear, Tom McKeithen, Sheila Robertson
BACKGROUND: The Collaborative for REMS Education (CO*RE) includes 13 organizations who provide REMS Program Companies (RPC) grant-supported accredited education on extended-release and long-acting (ER/LA) opioid therapy. This report summarizes results of a survey designed to investigate the impact of participant criteria and to better understand the roles and preferences of CME/CE participants. METHODS: In April 2015, we made an online survey available to an estimated 10,000 clinicians who had completed a CO*RE CME/CE activity since 2013...
April 18, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28417456/interventions-to-improve-adherence-to-inhaled-steroids-for-asthma
#18
REVIEW
Rebecca Normansell, Kayleigh M Kew, Elizabeth Stovold
BACKGROUND: Despite its proven efficacy in improving symptoms and reducing exacerbations, many patients with asthma are not fully adherent to their steroid inhaler. Suboptimal adherence leads to poorer clinical outcomes and increased health service utilisation, and has been identified as a contributing factor to a third of asthma deaths in the UK. Reasons for non-adherence vary, and a variety of interventions have been proposed to help people improve treatment adherence. OBJECTIVES: To assess the efficacy and safety of interventions intended to improve adherence to inhaled corticosteroids among people with asthma...
April 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28414799/comprehensive-evaluation-of-ten-deformable-image-registration-algorithms-for-contour-propagation-between-ct-and-cone-beam-ct-images-in-adaptive-head-neck-radiotherapy
#19
Xin Li, Yuyu Zhang, Yinghua Shi, Shuyu Wu, Yang Xiao, Xuejun Gu, Xin Zhen, Linghong Zhou
Deformable image registration (DIR) is a critical technic in adaptive radiotherapy (ART) for propagating contours between planning computerized tomography (CT) images and treatment CT/cone-beam CT (CBCT) images to account for organ deformation for treatment re-planning. To validate the ability and accuracy of DIR algorithms in organ at risk (OAR) contour mapping, ten intensity-based DIR strategies, which were classified into four categories-optical flow-based, demons-based, level-set-based and spline-based-were tested on planning CT and fractional CBCT images acquired from twenty-one head & neck (H&N) cancer patients who underwent 6~7-week intensity-modulated radiation therapy (IMRT)...
2017: PloS One
https://www.readbyqxmd.com/read/28414564/tivantinib-for-the-treatment-of-hepatocellular-carcinoma
#20
Jan Best, Clemens Schotten, Gregor Lohmann, Guido Gerken, Alexander Dechêne
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with a poor prognosis due to late diagnosis in the majority of cases. Physicians are frequently confronted with patients who are not eligible for curative or locoregional treatments any more. In this scenario, the multi-tyrosine kinase inhibitor sorafenib remains the only systemic first-line treatment option providing modest survival benefit compared to placebo with significant but for most patients acceptable adverse effects...
May 2017: Expert Opinion on Pharmacotherapy
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