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Paula Jimenez-Fonseca, Sebastian Krug, Gianluca Tamagno, F Fierro Maya, A Monleon Getino, C I Rodriguez Casado, Frederico Costa, Wouter W de Herder, Henning Jann
<br>Pancreatic neuroendocrine tumours (pNETs) represent rare neoplasms of all NETs often presenting without functional activity. Many sporadic non-functioning pNET patients are already metastatic at the time of diagnosis, and the therapeutic approach to such patients is mostly palliative. In this international, multicenter, retrospective cohort study we assessed the prognostic value of a set of anthropometric, clinical, biochemical, radiological, and pathological parameters at baseline and the impact of the therapeutic strategies on the survival of patients with sporadic grade 1/2, stage IV, non-functioning pNETs...
July 19, 2018: Neuroendocrinology
Ju-Fang Teng, Chien-Hsing Lee, Tai-Hao Hsu, Hui-Chen Lo
Polysaccharides derived from mushrooms have potential to control blood sugar, reduce insulin resistance and prevent diabetic complications. The intracellular polysaccharopeptides of Trametes versicolor (TV) have been used as immunologic and oncologic adjuvants. The aim of this study was to investigate the potential activities and mechanisms of extracellular polysaccharopeptides (ePSP) obtained from TV strain LH-1 on regulating glucose homeostasis. Human hepatoma HepG2 cells incubated with normal glucose (5...
2018: PloS One
Liang Zhang, DaLong Wan, Li Bao, Qing Chen, HaiYang Xie, ShiGuo Xu, ShengZhang Lin
RATIONALE: Neuroendocrine carcinoma (NEC) arising from the extrahepatic biliary tracts (EHBTs) is rare, and thus its management and prognosis remain poorly clarified. We herein describe a case of NEC in the perihilar EHBTs, and review the literature, together with a comparison between NECs in the perihilar and distal EHBTs, to elucidate the management strategy and oncological outcome of this rare entity. PATIENT CONCERNS: A 62-year-old Chinese male was admitted with complaints of painless jaundice...
July 2018: Medicine (Baltimore)
Fay Wright, Laura B Dunn, Steven M Paul, Yvette P Conley, Jon D Levine, Marilyn J Hammer, Bruce A Cooper, Christine Miaskowski, Kord M Kober
BACKGROUND: Morning fatigue is a distinct symptom experienced during chemotherapy that demonstrates significant interindividual variability. OBJECTIVES: The aims of this study were to identify subgroups with distinct morning fatigue profiles and evaluate how these subgroups differed by demographic, clinical, and symptom characteristics. METHODS: Outpatients (N = 1332) with breast, gastrointestinal, gynecological, or lung cancer completed questionnaires 6 times over 2 cycles of chemotherapy...
July 17, 2018: Cancer Nursing
Patrik Pipkorn, Kelsey Rosenquist, Joseph Zenga
PURPOSE OF REVIEW: The treatment of oral cavity cancer may impair speech and swallowing function. Optimizing posttreatment function may lead to significant improvement of quality of life. RECENT FINDINGS: Although oncologic control remains the main goal of treatment for oral cavity cancer, posttreatment function for surviving patients has over the last decades been recognized as an important secondary outcome. Reconstruction of oral cavity defects range from primary closure to advanced microvascular reconstruction, including multiple tissue types...
July 17, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
Alberto Pagan, Alessandro Bianchi, José Antonio Martínez, Marina Jiménez, Francisco Javier Gonzalez
In cancer patients with tumors of the upper gastrointestinal tract, dysphagia and cachexia require gastrostomy or jejunostomy as the only options for enteral access for long-term feeding. In this article, the authors describe a modified placement of laparoscopic feeding jejunostomy applied during laparoscopic oncology layering technique. After performing an exploratory laparoscopy, a feeding jejunostomy is performed using a Foley silicon catheter, through an eyelet in the mesentery of the descending colon. After completing the introduction of the jejunal probe according to the Witzel technique, the intestinal segment of jejunum is attached to the internal sheath of the mesocolon using sutures polysorb 2/0, with the aim of removing the possible internal hernia and a jejunal torque that could cause an intestinal obstruction...
2018: Turkish Journal of Surgery
Gülden Cancan, Serkan Teksöz, Süleyman Demiryas, Murat Özcan, Yusuf Bükey
Adrenal angiosarcoma is an uncommon neoplasm that derives from the vascular endothelium; due to its biological behavior, it should be distinguished from other adrenal tumors. We herein report a case of a 57-year-old woman with diagnosis of an adrenal tumor that was suspected to be malignant. The specimen was histopathologically proved to be an angiosarcoma. The patient was suffering from right upper quadrant pain; after laboratory and radiological workup, a non-functioning right adrenal mass, 14 cm in size, was recognized...
2018: Turkish Journal of Surgery
Srinivasaraghavan Kannan, Mohan R Pradhan, Joseph Cherian, Thomas L Joseph, Zhi Ying Poh, Yang Hai Yan, Ho Melvyn, Liu Boping, Hill Jeffrey, Kassoum Nacro, Chandra S Verma
Overexpression of the eukaryotic initiation factor 4E (eIF4E) is linked to a variety of cancers. Both mitogen-activated protein kinases-interacting kinases 1 and 2 (Mnk1/2) activate the oncogene eIF4E through posttranslational modification (phosphorylating it at the conserved Ser209). Inhibition of Mnk prevents eIF4E phosphorylation, making the Mnk-eIF4E axis a potential therapeutic target for oncology. Recently, the design and synthesis of a series of novel potent compounds inhibiting the Mnk1/2 kinases were carried out in-house...
November 30, 2017: ACS Omega
Elise D Cook, Katherine A Yeager, Reena S Cecchini, Jaskaran Boparai, Carol L Brown, Martha Duncan, Walter M Cronin, Electra D Paskett
Introduction: Cancer clinical trials (CCT) provide much of the evidence for clinical guidelines and standards of care. But low levels of CCT participation are well documented, especially for minorities. Methods and materials: We conducted an online survey of 556 recruitment practices across the NRG Oncology network. Survey aims were 1) to learn how sites recruit minority/underserved populations; 2) to better understand the catchment areas of the NRG institutions; and 3) to aid in planning education programs for accrual of minority/underserved populations...
June 2018: Contemporary Clinical Trials Communications
Marie Alix Balay, Patrick Aidan, Marie Helene Schlageter, Odette Georges, Taly Meas, Maroun Bechara, Marie Elisabeth Toubert, Isabelle Faugeron, Herve Monpeyssen, Cécile N Chougnet
Objectives: Transaxillary robotic thyroidectomy surgery (TARS) has been reported to be a safe approach in patients with differentiated thyroid carcinoma, and oncological responses are promising. Study Design: This study aimed to evaluate the oncological outcomes of TARS followed by radioiodine (RAI) therapy in patients with differentiated thyroid carcinoma. Between 2011 and 2016, patients treated for differentiated thyroid carcinoma by TARS in a single institution, followed by RAI, were retrospectively included...
June 2018: European Thyroid Journal
Malgorzata Szolkowska, Katarzyna Blasinska-Przerwa, Magdalena Knetki-Wroblewska, Piotr Rudzinski, Renata Langfort
No abstract text is available yet for this article.
June 2018: Journal of Thoracic Disease
Adolfo Romero, Juan Gómez-Salgado, Adolfo Romero-Arana, Carlos Ruiz-Frutos
Introduction: The presence of errors in the preanalytical phase is a thoroughly studied problem. A strategy to increase their source detection might be the use of the Healthcare Failure Mode and Effects Analysis (HFMEA). The aim of this study is improving the capacity of identifying sources of error during the preanalytical period in samples provided by primary care clinics (PCC) with the use of the HFMEA as a tool in the laboratories of two tertiary hospitals. Materials and methods: A HFMEA was carried out in each laboratory, by means of the creation of groups of experts with similar characteristics (doctors and nurses from PCC and laboratory, support staff, and laboratory technicians)...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
Gustavo Filipov Peres, Daniel Spadoto-Dias, Flávia Neves Bueloni-Dias, Nilton José Leite, Leonardo Vieira Elias, Maria Aparecida Custódio Domingues, Carlos Roberto Padovani, Rogério Dias
Objective: The aim of this study was to investigate the malignant potential of endometrial polyps (EP) by assessing the immunoexpressions of both estrogen receptor (ER) and progesterone receptor (PR), Ki-67 cell proliferation index, neovascularization network (endoglin - CD105), cellular adhesion molecules (claudins 3 and 4), and extracellular matrix proteins (MMP-2 and -9) in both EP and endometrioid adenocarcinoma (type I) in comparison with the normal endometrium. Study design: This is a cross-sectional comparative study...
2018: OncoTargets and Therapy
Erin A Blake, Madushka Y De Zoysa, Elise B Morocco, Samantha B Kaiser, Michiko Kodama, Brendan H Grubbs, Koji Matsuo
OBJECTIVE: To examine survival of teenage women with pregnancies complicated by primary ovarian cancer. METHODS: This is a secondary analysis of a previously organized systematic literature review of primary ovarian cancer diagnosed during pregnancy. Cases eligible for analysis were patients whose age at cancer diagnosis and survival outcome were known (n=201). Pregnancy and oncologic outcome were then examined based on patient age. RESULTS: These were comprised of 95 (47...
June 27, 2018: Journal of Gynecologic Oncology
Shin Nishio, Satomi Aihara, Mototsugu Shimokawa, Akira Fujishita, Shuichi Taniguchi, Toru Hachisuga, Shintaro Yanazume, Hiroaki Kobayashi, Fumihiro Murakami, Fumitaka Numa, Kohei Kotera, Naofumi Okura, Naoyuki Toki, Masatoshi Yokoyama, Kimio Ushijima
OBJECTIVE: Palonosetron is effective for the management of acute and delayed chemotherapy-induced nausea and vomiting (CINV). While emetogenic carboplatin-based chemotherapy is widely used to treat gynecologic cancers, few studies have evaluated the antiemetic effectiveness of palonosetron in this setting. METHODS: A multicenter, single-arm, open-label phase II trial was conducted to evaluate the safety and effectiveness of palonosetron in controlling CINV in patients with gynecologic cancer...
May 15, 2018: Journal of Gynecologic Oncology
Hung Chun Fu, Jen Ruei Chen, Min Yu Chen, Keng Fu Hsu, Wen Fang Cheng, An Jen Chiang, Yu Min Ke, Yu Chieh Chen, Yin Yi Chang, Chia Yen Huang, Chieh Yi Kang, Yuan Yee Kan, Sheng Mou Hsiao, Ming Shyen Yen
OBJECTIVE: Choice of hysterectomy and adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid endometrial cancer (EEC) is still controversial. Aims of this study were to evaluate survival benefits and adverse effects of different hysterectomies with or without adjuvant radiotherapy (RT), and to identify prognostic factors. METHODS: The patients at 14 member hospitals of the Taiwanese Gynecologic Oncology Group from 1992 to 2013 were retrospectively investigated...
May 15, 2018: Journal of Gynecologic Oncology
Soyi Lim, Yun Hwan Kim, Kwang Beom Lee, Jong Min Lee
OBJECTIVE: To determine whether drospirenone/estradiol (DRSP/E2) has an adverse effect on clinical outcomes in surgically staged International Federation of Gynecology and Obstetrics (FIGO) stage I/II endometrial cancer (EC) patients. METHODS: In a retrospective case-controlled study, 58 women with EC who had received DRSP/E2 postoperatively were compared with 116 women who had not. And, oncologic safety of postoperative hormone therapy with DRSP/E2 in EC survivors were compared between the 2 groups after propensity score matching using a logistic regression model...
May 4, 2018: Journal of Gynecologic Oncology
Koji Matsuo, Hiroko Machida, Andrea Mariani, Rachel S Mandelbaum, Gretchen E Glaser, Bobbie S Gostout, Lynda D Roman, Jason D Wright
OBJECTIVE: To examine the trends and survival for women with early-stage epithelial ovarian cancer who underwent adequate lymphadenectomy during surgical treatment. METHODS: This is a retrospective observational study examining the Surveillance, Epidemiology, End Results program between 1988 and 2013. We evaluated 21,537 cases of stage I-II epithelial ovarian cancer including serous (n=7,466), clear cell (n=6,903), mucinous (n=4,066), and endometrioid (n=3,102) histology...
May 4, 2018: Journal of Gynecologic Oncology
Leonardo Micheletti, Mario Preti, Viviana Cintolesi, Elisabetta Corvetto, Silvana Privitera, Eleonora Palmese, Chiara Benedetto
OBJECTIVE: We aimed to identify the minimum tumor-free margin distance conferring long-term oncological safety in patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IB/II vulvar squamous cell carcinoma (VSCC). METHODS: This was a retrospective cohort study in patients with stage IB/II VSCC treated at a single institution in Turin, Italy. The main aim was to identify the minimum tumor-free margin distance that confers oncological safety in early-stage VSCC...
April 13, 2018: Journal of Gynecologic Oncology
Steven W Cole
No abstract text is available yet for this article.
July 18, 2018: Psycho-oncology
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