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https://www.readbyqxmd.com/read/28545168/reliability-of-the-triple-timed-up-and-go-3tug-test
#1
Donald B Sanders, Jeffrey T Guptill, Kathy L Aleš, Lisa D Hobson-Webb, David P Jacobus, Riaz Mahmood, Janice M Massey, Melissa M Pittman, Kristi Prather, Shruti M Raja, Eric Yow, Vern C Juel
INTRODUCTION: We report the reliability of a new measure, the Triple Timed-Up-and-Go (3TUG) test, for assessing clinical function in patients with Lambert-Eaton myasthenia (LEM). METHODS: Intra-rater reproducibility and inter-rater agreement of the 3TUG were assessed in 25 control subjects, 24 patients with non-LEM neuromuscular disease and 12 LEM patients. The coverage probability (CP) method was the primary measure of reproducibility and agreement. The a priori acceptable range was <20% difference in 3TUG times and a CP ≥0...
May 25, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28545162/the-almost-unbearable-lightness-of-personality
#2
Jüri Allik
Researchers seem to believe that accepting the reality of personality traits inevitably leads to a dogma about the incredible complexity of these traits and their judgment. This paper challenges this thesis and its assertion that the accuracy of personality judgment can only be achieved when a "good target" or a "good trait" is being judged using "good information," and when a "good judge" makes the judgment. It is argued that because trait dimensions are universally applicable to all persons there is no stable ranking of good targets...
May 25, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28544980/what-we-authors-reviewers-and-editors-of-scientific-work-can-learn-from-the-analytical-history-of-biological-3-nitrotyrosine
#3
REVIEW
Dimitrios Tsikas
Tyrosine and tyrosine residues in proteins are attacked by the reactive oxygen and nitrogen species peroxynitrite (O=N-OO(-)) to generate 3-nitrotyrosine (3-NT) and 3-nitrotyrosine-proteins (3-NTProt), respectively. 3-NT and 3-NTProt are widely accepted as biomarkers of nitr(os)ative stress. Over the years many different analytical methods have been reported for 3-NT and 3-NTProt. Reported concentrations often differ by more than three orders of magnitude, indicative of serious analytical problems. Strategies to overcome pre-analytical and analytical shortcomings and pitfalls have been proposed...
May 13, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28544978/documentation-of-50-water-conservation-in-a-single-process-at-a-beef-abattoir
#4
C L Drennan, R E DeOtte, T E Lawrence
Beef slaughter is water intensive due to stringent food safety requirements. We conducted a study at a commercial beef processor to demonstrate water conservation by modifying the mechanical head wash. We documented the initial nozzle configuration (112 nozzles), water pressure (275kPa), and flowrate (152L/head washed), then developed a 3-D CAD model to identify regions of water use redundancy. The mechanical head wash was modified by reducing nozzle count (72), decreasing pressure (138kPa) and flowrate (78...
May 17, 2017: Meat Science
https://www.readbyqxmd.com/read/28544950/the-influence-of-continuous-versus-interval-walking-exercise-on-knee-joint-loading-and-pain-in-patients-with-knee-osteoarthritis
#5
Shawn Farrokhi, Prakash Jayabalan, Jonathan A Gustafson, Brian A Klatt, Gwendolyn A Sowa, Sara R Piva
OBJECTIVE: To evaluate whether knee contact force and knee pain are different between continuous and interval walking exercise in patients with knee osteoarthritis (OA). METHODS: Twenty seven patients with unilateral symptomatic knee OA completed two separate walking exercise sessions on a treadmill at 1.3m/s on two different days: 1) a continuous 45min walking exercise session, and 2) three 15min bouts of walking exercise separated by 1h rest periods for a total of 45min of exercise in an interval format...
May 17, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28544842/transfemoral-valve-in-valve-in-a-degenerated-small-aortic-bioprosthesis-five-year-follow-up
#6
Stefano Salizzoni, Federico Conrotto, Mauro Rinaldi, Gian Paolo Ussia, Gaetana Ferraro, Mauro Giorgi, Maurizio D'Amico
A small-sized bioprosthesis can limit transcatheter valve-in-valve (V-in-V) implantations. The case is reported of a 91-year-old woman who had successfully undergone a V-in-V procedure with a 26 mm CoreValve in a previously implanted Mitroflow 19 mm valve. At the five-year follow up the prosthesis showed good echocardiographic function and the patient was alive and free from major symptoms. The patient died three months after the follow up examination at the age of 96 years. This case demonstrates the feasibility, with acceptable longterm functioning, of a V-in-V procedure involving a small bioprosthesis...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544834/in-vitro-pulsatile-flow-measurement-in-prosthetic-heart-valves-an-inter-laboratory-comparison
#7
Stephen M Retta, Jeff Kepner, Salvador Marquez, Bruce A Herman, Mark C S Shu, Laurence W Grossman
BACKGROUND AND AIM OF STUDY: One of the first steps in qualifying a new prosthetic valve for eventual clinical use is preclinical flow performance testing in vitro. Such testing is typically performed in an in-vitro test system that simulates the pumping mechanics of the left ventricle of the heart, generally referred to as a pulse duplicator or duplicator. Historically, test results in these systems have varied from duplicator to duplicator. This collaborative effort between heart valve manufacturers and the Food and Drug Administration (FDA) was designed to evaluate the variability of the pulse duplicator test technology for pulsatile flow performance measurement in an interlaboratory round robin...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544828/acute-aortic-regurgitation-in-the-current-era-of-percutaneous-treatment-pathophysiology-and-hemodynamics
#8
Baris Bugan, Erkan Yildirim, Murat Celik, Uygar Cagdas Yuksel
Aortic regurgitation (AR) is characterized by the backflow of blood from the aorta to the left ventricle. Acute AR typically causes severe pulmonary edema and hypotension, and is a surgical emergency. In chronic AR, however, compensatory mechanisms can clinically compensate for years, with normal left ventricular function and no symptoms. While the hemodynamic mechanisms of chronic AR on the left ventricle are well described, the hemodynamic mechanisms of acute AR are not clear. Most of the literature on acute AR includes either small series or case reports...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544802/prognostic-models-and-nomograms-for-predicting-survival-of-patients-with-maxillary-sinus-carcinomas
#9
Weidong Shen, Naoko Sakamoto, Limin Yang
BACKGROUND: Maxillary sinus carcinoma is an uncommon malignancy. Most reports on prognosis of this disease are from single institutions and include few patients. We used data from the United States National Cancer Institute's Surveillance Epidemiology and End Results (SEER) program to construct models and nomograms for predicting outcomes of patients with maxillary sinus carcinomas. METHODS: We used records from 668 patients with primary maxillary sinus carcinomas reported to the SEER program from 2004 to 2013 to build nomograms based on stratified multivariable Cox proportional hazard models for predicting 5-year overall survival (OS) and cause-specific survival (CSS)...
May 23, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28544746/clinical-outcomes-following-proton-therapy-for-children-with-central-nervous-system-tumors-referred-overseas
#10
Daniel J Indelicato, Julie A Bradley, Eric S Sandler, Philipp R Aldana, Amy Sapp, Jennifer E Gains, Adrian Crellin, Ronny L Rotondo
BACKGROUND: International, multidisciplinary care of children with central nervous system (CNS) tumors presents unique challenges. The aim of this study is to report patient outcomes of U.K. children referred for proton therapy to a North American facility. METHODS: From 2008 to 2016, 166 U.K. children with approved CNS tumors were treated with proton therapy at a single academic medical center in the United States. Median age was 7 years (range, 1-19). Median follow-up was 2...
May 24, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28544745/fs-laser-ablation-of-teeth-is-temperature-limited-and-provides-information-about-the-ablated-components
#11
Rebeca Ferraz de Menezes, Catherine Malinda Harvey, Marleny Elizabeth Márquez de Martínez Gerbi, Zachary J Smith, Dan Smith, Juan C Ivaldi, Alton Phillips, James W Chan, Sebastian Wachsmann-Hogiu
The goal of this work is to investigate the thermal effects of femtosecond laser (fs-laser) ablation for the removal of carious dental tissue. Additional studies identify different tooth tissues through femtosecond laser induced breakdown spectroscopy (fsLIBS) for the development of a feedback loop that could be utilized during ablation in a clinical setting. Scanning Election Microscope (SEM) images reveal that minimal morphological damages are incurred at repetition rates below the carbonization threshold of each tooth tissue...
May 24, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28544728/index-case-finding-facilitates-identification-and-linkage-to-care-of-children-and-young-adults-living-with-hiv-aids-in-malawi
#12
Saeed Ahmed, Rachael A Sabelli, Katie Simon, Nora E Rosenberg, Elijah Kavuta, Mwelura Harawa, Spencer Dick, Frank Linzie, Peter N Kazembe, Maria H Kim
OBJECTIVES: Evaluation of a novel index case-finding and linkage-to-care program to identify and link HIV-infected children (1-15 years) and young adults (>15-24 years) to care. METHODS: HIV-infected patients enrolled in HIV services were screened and those who reported untested household members (index cases) were offered home or facility-based HIV testing and counseling (HTC) of their household by a community health worker (CHW). HIV-infected household members identified were enrolled in a follow-up program offering home and facility-based follow-up by CHWs...
May 23, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28544673/biocatalytic-friedel-crafts-acylation-and-fries-reaction
#13
Nina G Schmidt, Tea Pavkov-Keller, Nina Richter, Birgit Wiltschi, Karl Gruber, Wolfgang Kroutil
The Friedel-Crafts acylation is commonly used for the synthesis of aryl ketones, and a biocatalytic version, which may benefit from the chemo- and regioselectivity of enzymes, has not yet been introduced. Described here is a bacterial acyltransferase which can catalyze Friedel-Crafts C-acylation of phenolic substrates in buffer without the need of CoA-activated reagents. Conversions reach up to >99 %, and various C- or O-acyl donors, such as DAPG or isopropenyl acetate, are accepted by this enzyme. Furthermore the enzyme enables a Fries-like rearrangement reaction of resorcinol derivatives...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544653/minimally-invasive-dental-anesthesia-patients-preferences-and-analysis-of-the-willingness-to-pay-index
#14
Dino Re, Massimo Del Fabbro, Lorena Karanxha, Gabriele Augusti, Davide Augusti, Sabrine Fessi, Silvio Taschieri
AIM: The aim of the present prospective study was to evaluate the impact of a computer-controlled anesthesia on patients' comfort and to investigate, through the willingness-to-pay (WTP) index, and patients' acceptance of this new technology. METHODS: Fifty patients undergoing a class I or II restorative procedure were enrolled. A computer-controlled device for anesthetic delivery was utilized, and a questionnaire on the level of discomfort and WTP was given to all patients...
May 23, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28544642/evaluation-of-a-targeted-prescriber-education-intervention-on-emergency-department-discharge-oxycodone-prescribing
#15
Síne R Donaldson, Andrew M Harding, Simone E Taylor, Hassan Vally, Shaun L Greene
OBJECTIVES: The objective of this study was to evaluate the impact of an educational intervention on ED discharge opioid analgesic (OA) prescribing. METHODS: A brief, one-on-one, educational intervention was delivered to ED OA prescribers by an ED clinical champion. The percentage of patients receiving (i) written advice regarding appropriate oxycodone use, (ii) written or verbal advice regarding appropriate post-discharge follow up and (iii) written general practitioner notification that oxycodone had been prescribed were determined pre- and post-intervention, through review of electronic patient records and structured patient telephone interviews conducted 3-7 days after ED attendance...
May 24, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28544615/suppressing-inflammation-in-rheumatoid-arthritis-does-patient-global-assessment-blur-the-target-a-practice-based-call-for-a-paradigm-change
#16
Ricardo J O Ferreira, Cátia Duarte, Mwidimi Ndosi, Maarten de Wit, Laure Gossec, J A P da Silva
OBJECTIVES: In current management paradigms of Rheumatoid Arthritis (RA), patient global assessment (PGA) is crucial to decide whether a patient has attained remission (target) or needs reinforced therapy. We investigated whether the clinical and psychological determinants of PGA are appropriate to support this important role. METHODS: This was a cross-sectional, single centre study including consecutive ambulatory RA patients. Data collection comprised swollen (SJC28) and tender joint counts (TJC28), C-Reactive protein (CRP), PGA, pain, fatigue, function, anxiety, depression, happiness, personality traits, and comorbidities...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28544551/electronic-based-lifestyle-interventions-in-overweight-or-obese-perinatal-women-a-systematic-review-and-meta-analysis
#17
REVIEW
Y Lau, P Klainin-Yobas, T P Htun, S N Wong, K L Tan, S T Ho-Lim, C Chi, C Tsai, K W Ong, S Shorey, W S W Tam
Electronic-based (e-based) lifestyle interventions provide potential and cost-effective delivery of remote interventions for overweight and obese perinatal women. To date, no meta-analysis has reported the efficacy of maternal and neonatal outcomes. Seven electronic databases were searched from inception up to July 13, 2016, including the Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, EMBASE, ProQuest Dissertations and Theses, PsycINFO, PubMed and Scopus. Among the 1,145 studies retrieved, 14 randomized controlled trials were selected among 17 publications...
May 22, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28544526/hetero-face-to-face-porphyrin-array-with-the-cooperative-effects-of-coordination-and-host-guest-complexation
#18
Yusuke Chiba, Maning Liu, Yasuhiro Tachibana, Tetsuaki Fujihara, Yasushi Tsuji, Jun Terao
We successfully synthesized a hetero face-to-face porphyrin array composed of ZnTPP and RuTPP(DABCO)₂ (TPP: 5,10,15,20-tetraphenylporphyrin, DABCO: 1,4-diazabi-cyclo[2.2.2]octane) in 2:1 molar ratio. A cyclic Zn porphyrin dimer (ZnCP) was also used as the host molecule for the Ru porphyrin. In the latter, the Ru-DABCO bonding in RuTPP(DABCO)₂ was stabilized by the host-guest complexation. Reaction progress kinetic analysis of the ligand substitution reaction of RuTPP(DABCO)₂ and that in ZnCP revealed the stabilization mechanism of the Ru-DABCO bonding...
May 22, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28544422/assessment-of-clinically-relevant-bleeding-as-a-surrogate-outcome-for-major-bleeding-validation-by-meta-analysis-of-randomized-controlled-trials
#19
S Laporte, C Chapelle, L Bertoletti, E Ollier, P Zufferey, J-C Lega, A Merah, H Décousus, S Schulman, G Meyer, M Cucherat, P Mismetti
BACKGROUND: Clinically relevant bleeding (CRB), comprising major bleeding and clinically relevant non-major bleeding, has been used as a surrogate for major bleeding in most anticoagulant trials, but its validity for estimating compromise between thrombotic and bleeding events has never been assessed. METHODS: We systematically reviewed randomized phase III trials comparing new anticoagulants with standard of care for venous thromboembolism prevention following major orthopedic surgery, venous thromboembolism (VTE) treatment, or stroke and systemic embolism prevention in atrial fibrillation (AF), and reporting both major bleeding and CRB rates...
May 20, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28544419/photo-induced-cyclization-of-o-alkylbenzoyl-phosphonates-to-benzocyclobutenols
#20
Naoki Ishida, Takaaki Yano, Tatsuya Yuhki, Masahiro Murakami
(o-Alkylbenzoyl)phosphonates readily cyclize to highly strained benzocyclobutenols simply upon irradiation with UV light. The remarkable efficiency is ascribed to the electron-accepting character of the phosphonate substituent, which facilitates thermal ring closing of the o-quinodimethane intermediate and suppresses reversion to the starting carbonyl compound.
May 23, 2017: Chemistry, An Asian Journal
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