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https://www.readbyqxmd.com/read/29245086/liquid-chromatography-tandem-mass-spectrometric-assay-for-the-quantitation-of-the-novel-radiation-protective-agent-and-radiation-mitigator-jp4-039-in-murine-plasma
#1
Susan Christner, Jianxia Guo, Robert A Parise, Melanie Ringeval, Adam T Hoye, Peter Wipf, Michael W Epperly, Joel S Greenberger, Jan H Beumer, Julie L Eiseman
JP4-039 radio-protects prior to, and radio-mitigates after ionizing radiation by neutralizing reactive oxygen species. We developed and validated an LC-MS/MS assay for the quantitation of JP4-039 in murine plasma. Methanol protein precipitation of 50μL plasma was followed by isocratic reverse phase chromatography for a 6min run time, and electrospray positive mode ionization mass spectrometric detection. The plasma assay was linear from 1 to 1000ng/mL with appropriate accuracy (97.1-107.6%) and precision (3...
December 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29245084/application-of-analytical-quality-by-design-principles-for-the-determination-of-alkyl-p-toluenesulfonates-impurities-in-aprepitant-by-hplc-validation-using-total-error-concept
#2
Constantinos K Zacharis, Elli Vastardi
In the research presented we report the development of a simple and robust liquid chromatographic method for the quantification of two genotoxic alkyl sulphonate impurities (namely methyl p-toluenesulfonate and isopropyl p-toluenesulfonate) in Aprepitant API substances using the Analytical Quality by Design (AQbD) approach. Following the steps of AQbD protocol, the selected critical method attributes (CMAs) were the separation criterions between the critical peak pairs, the analysis time and the peak efficiencies of the analytes...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29245083/concordance-between-the-wada-test-and-neuroimaging-lateralization-influence-of-imaging-modality-fmri-and-meg-and-patient-experience
#3
Steven Kemp, Garreth Prendergast, Theodoros Karapanagiotidis, Gus Baker, Thomas P Kelly, Tufail Patankar, Simon S Keller
The Wada test remains the traditional test for lateralizing language and memory function prior to epilepsy surgery. Functional imaging, particularly functional MRI (fMRI), has made progress in the language domain, but less so in the memory domain. Magnetoencephalography (MEG) has received less research attention, but shows promise, particularly for language lateralization. We recruited a consecutive sample of 19 patients with epilepsy who had completed presurgical work-up, including the Wada test, and compared fMRI (memory) and MEG (language and memory) with Wada test results...
December 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29245004/a-standardized-preoperative-group-intervention-is-feasible-and-acceptable-to-orthognathic-surgery-patients
#4
Xialong Li, Debra L Safer, Imilce Castro Paz, Roseanne Menorca, Sabine Girod
PURPOSE: Nearly 10% of patients remain dissatisfied after orthognathic surgery, largely because of psychoeducational or psychosocial factors. The purpose of this study was to evaluate the feasibility and acceptability of a psychoeducationally based group intervention to improve preoperative preparation of orthognathic surgical patients and their caregivers. MATERIALS AND METHODS: The intervention consisted of 2 group sessions, with each session lasting 2 hours...
November 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29244984/cancer-pathology-turnaround-time-at-queen-elizabeth-central-hospital-the-largest-referral-center-in-malawi-for-oncology-patients
#5
Leo P L Masamba, Petani E Mtonga, Linda Kalilani Phiri, Brittany L Bychkovsky
Purpose In all settings, a need exists for expedited pathology processing for patients with a suspected cancer diagnosis. In low- and middle-income countries (LMICs) with limited resources, processing pathology samples is particularly challenging, so the measurement of turnaround times (TATs) for pathology results is an important quality metric. We explored the pathology TAT for suspected cancer patients at Queen Elizabeth Central Hospital in Malawi to determine whether a difference exists when patients paid an out-of-pocket fee (paid for [PF] v nonpaid for [NPF]) to facilitate sample processing...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244883/effects-of-mechanical-repetitive-load-on-bone-quality-around-implants-in-rat-maxillae
#6
Yusuke Uto, Shinichiro Kuroshima, Takayoshi Nakano, Takuya Ishimoto, Nao Inaba, Yusuke Uchida, Takashi Sawase
Greater understanding and acceptance of the new concept "bone quality", which was proposed by the National Institutes of Health and is based on bone cells and collagen fibers, are required. The novel protein Semaphorin3A (Sema3A) is associated with osteoprotection by regulating bone cells. The aims of this study were to investigate the effects of mechanical loads on Sema3A production and bone quality based on bone cells and collagen fibers around implants in rat maxillae. Grade IV-titanium threaded implants were placed at 4 weeks post-extraction in maxillary first molars...
2017: PloS One
https://www.readbyqxmd.com/read/29244832/productivity-impact-and-collaboration-differences-between-transdisciplinary-and-traditionally-trained-doctoral-students-a-comparison-of-publication-patterns
#7
Anna-Sigrid Keck, Stephanie Sloane, Janet M Liechty, Barbara H Fiese, Sharon M Donovan
Transdisciplinary (TD) approaches are increasingly used to address complex public health problems such as childhood obesity. Compared to traditional grant-funded scientific projects among established scientists, those designed around a TD, team-based approach yielded greater publication output after three to five years. However, little is known about how a TD focus throughout graduate school training may affect students' publication-related productivity, impact, and collaboration. The objective of this study was to compare the publication patterns of students in traditional versus TD doctoral training programs...
2017: PloS One
https://www.readbyqxmd.com/read/29244803/changes-in-brain-morphology-and-microstructure-in-relation-to-early-brain-activity-in-extremely-preterm-infants
#8
Maria Luisa Tataranno, Nathalie H P Claessens, Pim Moeskops, Mona C Toet, Karina J Kersbergen, Giuseppe Buonocore, Ivana Išgum, Alexander Leemans, Serena Counsell, Floris Groenendaal, Linda S de Vries, Manon J N L Benders
OBJECTIVE: To investigate the relation of early brain activity with structural (growth of the cortex and cerebellum) and white matter microstructural brain development. METHODS: 33 preterm neonates (gestational age 26±1 weeks) without major brain abnormalities were continuously monitored with electroencephalography (EEG) during the first 48 h of life. Rate of spontaneous activity transients per minute (SAT rate) and interSAT interval (ISI) in seconds per minute were calculated...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244802/elevations-of-inflammatory-proteins-in-neonatal-blood-are-associated-with-obesity-and-overweight-among-2-year-old-children-born-extremely-premature
#9
Eliana M Perrin, T Michael O'Shea, Asheley Cockrell Skinner, Carl Bose, Elizabeth N Allred, Raina N Fichorova, Jelske W van der Burg, Alan Leviton
BACKGROUND: Childhood obesity is associated with elevated blood concentrations of inflammation markers. It is not known to what extent inflammation precedes the development of obesity. METHODS: In a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age. RESULTS: Among children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244801/hope-vs-caution-ethical-and-regulatory-considerations-for-neonatal-stem-cell-therapies
#10
Naomi Laventhal, Scott Rivkees, Valerie Opipari
Pediatric Research accepted article preview online, 15 December 2017. doi:10.1038/pr.2017.320.
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244800/hla-dq-genetics-in-children-with-celiac-disease-a-meta-analysis-suggesting-a-two-step-genetic-screening-procedure-starting-with-hla-dq-%C3%AE-chains
#11
Annalisa De Silvestri, Cristina Capittini, Dimitri Poddighe, Chiara Valsecchi, Gianluigi Marseglia, Sara Carlotta Tagliacarne, Valeria Scotti, Chiara Rebuffi, Annamaria Pasi, Miryam Martinetti, Carmine Tinelli
OBJECTIVES: through a meta-analysis, evaluating the distribution of the predisposing HLA genotype to Celiac Disease (CD) in children and providing insights for potential widened screening strategy. STUDY DESIGN: After a systematic search on the association between HLA class II and CD in children, 46 publications were obtained and assessed for eligibility. 13 eligible studies were submitted to data extraction and analysis (10 studies case-control and 3 cohort studies)...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244799/prenatal-and-early-postnatal-measures-of-brain-development-and-childhood-sleep-patterns
#12
Desana Kocevska, Maria E Verhoeff, Selma Meinderts, Vincent W Jaddoe, Frank C Verhulst, Sabine J Roza, Maartje P C M Luijk, Henning Tiemeier
BACKGROUND: Brain development underlies maturation of sleep patterns throughout childhood. Intrauterine head growth -marker of early neurodevelopment- has not been associated with childhood sleep characteristics. We explored associations between ultrasonographic measures of prenatal and early postnatal neurodevelopment and childhood sleep. METHODS: Six-thousand-five-hundred-twenty-eight children from a population-based birth cohort (Generation R) were included. Head circumference (HC) and lateral ventricles size were assessed with mid- and late-pregnancy fetal ultrasounds, and with cranial ultrasound 3-20 weeks postnatally...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244798/amplitude-integrated-electroencephalography-during-the-first-72-hours-after-birth-in-neonates-diagnosed-prenatally-with-congenital-heart-disease
#13
Mirthe J Mebius, Nathalie J E Oostdijk, Sara J Kuik, Arend F Bos, Rolf M F Berger, Caterina M Bilardo, Elisabeth M W Kooi, Hendrik J Ter Horst
BACKGROUND: Little is known on amplitude-integrated electroencephalography (aEEG) during the first days after birth in neonates with CHD. Our aim was, therefore, to assess electro-cortical activity using aEEG within the first 72 h after birth in neonates diagnosed prenatally with CHD, and to define independent prenatal and postnatal predictors for abnormal aEEG. METHODS: Neonates with CHD that were admitted to the neonatal intensive care unit between 2010 and 2017 were retrospectively included...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244797/association-between-maternal-hypothyroidism-and-autism-spectrum-disorders-in-the-children
#14
Darios Getahun, Steven J Jacobsen, Michael J Fassett, Deborah A Wing, Anny H Xiang, Vicki Chiu, Morgan R Peltier
OBJECTIVE: To determine if hypothyroidism is associated with ASD and how this association is influenced by race-ethnicity, sex, and timing of exposure. METHODS: A retrospective cohort study was conducted using records from 397201 children who were delivered from 1991-2011 and remained health plan members from 1993-2014. RESULTS: Children of hypothyroid women had higher ASD rates than children of women without the diagnosis (2.14 vs. 1.62/1000 person-years; and adjusted hazard ratios [adj...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244796/rsv-bronchiolitis-versus-rhinovirus-difference-in-nasal-airway-microrna-profiles-and-nf%C3%AE%C2%BAb-signaling
#15
Kohei Hasegawa, Marcos Pérez-Losada, Claire E Hoptay, Samuel Epstein, Jonathan M Mansbach, Stephen J Teach, Pedro A Piedra, Carlos A Camargo, Robert J Freishtat
BACKGROUND: Although rhinovirus infection is associated with increased risks of acute and chronic respiratory outcomes during childhood compared with respiratory syncytial virus (RSV), the underlying mechanisms remain unclear. We aimed to determine differences in nasal airway microRNA profiles and their downstream effects between infants with rhinovirus and RSV bronchiolitis. METHODS: As part of multicenter cohort study of infants hospitalized for bronchiolitis, we examined nasal samples obtained from 16 infants with rhinovirus and 16 infants with RSV...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244795/jack-widness-the-importance-of-connections
#16
Steven J McElroy
Pediatric Research accepted article preview online, 15 December 2017. doi:10.1038/pr.2017.317.
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244794/health-implications-of-dietary-habits-in-transition-countries-a-life-course-perspective
#17
Carlo Agostoni, Marco Silano, Giovanni Fattore
Pediatric Research accepted article preview online, 15 December 2017. doi:10.1038/pr.2017.319.
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244793/effects-of-epinephrine-on-hemodynamic-changes-during-cardiopulmonary-resuscitation-in-a-neonatal-piglet-model
#18
Michael Wagner, Po-Yin Cheung, Elliott S Li, Tze-Fun Lee, Min Lu, Megan O'Reilly, Monika Olischar, Georg M Schmölzer
BACKGROUND: Asphyxia is the most common reason for newborns to fail to make a successful fetal to neonatal transition. There is currently a lack of data evaluating hemodynamic effects of epinephrine during neonatal cardiopulmonary resuscitation. METHODS: Twenty-four newborn piglets were exposed to asphyxia. Thereafter, positive pressure ventilation was commenced for 30 s, followed by chest compressions (CC). Piglets were randomized into three experimental groups: 3:1 compression:ventilation ratio; CC during sustained inflation (SI) at a rate of 90 CC per minute, or CC during SI at a rate of 120 CC per minute...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244792/tight-glycemic-control-in-critically-ill-pediatric-patients-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#19
Yiyang Zhao, Yang Wu, Bo Xiang
BACKGROUND: There still are controversies in the impact of tight glycemic control (TGC) in critically ill children. The aim of this study was to assess the benefits and risks of TGC compared with conventional glycemic control (CGC) in critically ill pediatric patients admitted to the pediatric intensive care unit (PICU) by using data retrieved from randomized controlled trials (RCTs). METHOD: EMBASE, CNKI, PubMed and the Cochrane Database were searched for RCTs comparing TGC with CGC in critically ill children in PICU...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244791/management-and-outcomes-of-childhood-goodpasture-s-disease
#20
Carmela P Menzi, Barbara S Bucher, Mario G Bianchetti, Gianluigi Ardissino, Giacomo D Simonetti
BACKGROUND: In an attempt to improve knowledge about childhood Goodpasture's disease, we performed a retrospective analysis of patients with Goodpasture's disease from several pediatric nephrology centers. METHODS: We analyzed the responses to 27 questions that elicited information about the following: incidence, demographics, patient history and clinical presentation, diagnostics performed, acute and chronic therapy, course of disease and outcome. RESULTS: Goodpasture's disease, which is extremely rare in this age group, may manifest in 2-year-old toddlers and does not typically present with pulmonary findings before puberty...
December 15, 2017: Pediatric Research
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