Elena Pontarini, Elisabetta Sciacca, Farzana Chowdhury, Sofia Grigoriadou, Felice Rivellese, William J Murray-Brown, Davide Lucchesi, Liliante Fossati-Jimack, Alessandra Nerviani, Edyta Jaworska, Giulia Maria Ghirardi, Chiara Giacomassi, Paul Emery, Wan Fai Ng, Nurhan Sutcliffe, Colin Everett, Catherine Fernandez, Anwar Tappuni, Raphael Seror, Xavier Mariette, Raphael Porcher, Giulia Cavallaro, Alfredo Pulvirenti, Gwenny M Verstappen, Liseth de Wolff, Suzanne Arends, Hendrika Bootsma, Miles J Lewis, Constantino Pitzalis, Simon J Bowman, Michele Bombardieri
OBJECTIVE: This study aimed to identify peripheral and salivary gland (SG) biomarkers of response/resistance to B cell depletion based on the novel concise Composite of Relevant Endpoints for Sjögren Syndrome (cCRESS) and candidate Sjögren Tool for Assessing Response (STAR) composite endpoints. METHODS: Longitudinal analysis of peripheral blood and SG biopsies was performed pre- and post-treatment from the Trial of Anti-B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS) combining flow cytometry immunophenotyping, serum cytokines, and SG bulk RNA sequencing...
December 10, 2023: Arthritis & Rheumatology