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Bone mineral density and fractures

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https://www.readbyqxmd.com/read/29028103/expressions-of-il-1%C3%AE-and-mmp-9-in-degenerated-lumbar-disc-tissues-and-their-clinical-significance
#1
P-B Li, W-J Tang, K Wang, K Zou, B Che
OBJECTIVE: To observe the expression levels of interleukin-1α (IL-1α) and matrix metalloproteinase-9 (MMP-9) in degenerated lumbar disc tissues and to investigate their clinical significance. PATIENTS AND METHODS: Fifty patients with lumbar disc degeneration received the operative treatment were divided into three groups according to the magnetic resonance imaging (MRI) results: protrusion group, extrusion group, and free group. The degenerated intervertebral disc tissues were taken, and the normal intervertebral disc tissues of 20 patients received the operative treatment due to lumbar bursting fracture, and were selected as the control group...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027270/the-yerba-mate-intake-has-a-neutral-effect-on-bone-a-case-control-study-in-postmenopausal-women
#2
Denise T A da Veiga, Raísa Bringhenti, Aline A Bolignon, Etiane Tatsh, Rafael N Moresco, Fabio V Comim, Melissa O Premaor
Nutritional factors have been associated with osteoporosis and fractures. The intake of coffee may increase the risk of fracture whereas the intake of black and green tea is associated with its reduction. Recently, consumption of yerba mate was associated with increased bone mineral density in postmenopausal women. Nonetheless, its influence on fracture is not known. The aim of this study was to evaluate the effect of yerba mate tea intake on fractures, bone markers, calcium homeostasis, and oxidative stress in postmenopausal women...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29027045/characteristics-of-patients-with-fragility-hip-fractures-in-the-northern-kyushu-district-in-japan-a-multicenter-prospective-registry-based-on-an-electronic-data-capture-system
#3
Akiko Oyamada, Yoshihiro Matsumoto, Yoshifumi Wakata, Atsushi Kimura, Ko Ikuta, Kuniyoshi Tsuchiya, Naohisa Tayama, Shinji Tomari, Hisaaki Miyahara, Takao Mae, Hirokazu Shiraishi, Taichi Saito, Takeshi Arizono, Kozo Kaji, Taro Mawatari, Masami Fujiwara, Riku Sakimura, Kunichika Shin, Kenichi Ninomiya, Kazutoshi Nakaie, Yasuaki Antoku, Shoji Tokunaga, Naoki Nakashima, Yukihide Iwamoto, Yasuharu Nakashima
Osteoporosis has become a worldwide public health problem, in part due to the fact that it increases the risk of fragility hip fractures (FHFs). The epidemiological assessment of FHFs is critical for their prevention; however, datasets for FHFs in Japan remain scarce. This was a multicenter, prospective, observational study in the northern district of Kyushu Island. Inclusion criteria were age > 60 years with a diagnosis of FHF and acquisition of clinical data by an electronic data capture system. Of 1294 registered patients, 1146 enrolled in the study...
October 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29024249/bone-strength-in-girls-and-boys-following-a-distal-radius-fracture-a-2-year-hr-pqct-double-cohort-study
#4
Heather M Macdonald, Mikko Määttä, Leigh Gabel, Kishore Mulpuri, Heather A McKay
PURPOSE: We recently reported impaired bone strength in girls with low- to moderate-energy distal radius fractures (Fx) compared with girls with no history of forearm fractures (Non-Fx). We aimed to determine whether bone strength deficits observed at baseline were still present after two years. METHODS: We assessed bone strength, microarchitecture and BMD of the non-fractured (Fx) and non-dominant (Non-Fx) distal radius (7% site) at baseline, 12- and 24-months using high-resolution pQCT (Scanco Medical) in 104 girls (11...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29023918/scrutinizing-the-genetic-underpinnings-of-bone-strength
#5
Fernando Rivadeneira, Andre G Uitterlinden
Every year osteoporosis causes millions of fractures worldwide, with the lifetime risk of suffering a wrist, hip or vertebral fracture estimated to be about 30% in developed countries [1]. Osteoporosis has been operationally defined for diagnostic and treatment purposes on the basis of the bone mineral density (BMD) assessment performed at the skeletal sites where fracture is most common. Nevertheless, BMD measurement alone is not optimal for the detection of individuals at high risk of fracture.
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29023690/the-bony-horncore-of-the-common-eland-taurotragus-oryx-composition-and-mechanical-properties-of-a-spiral-fighting-structure
#6
Jamil Cappelli, Andrés J García, Radim Kotrba, Pablo Gambín Pozo, Tomas Landete-Castillejos, Laureano Gallego, Francisco Ceacero
Horns are permanent structures projecting from the head of bovids, consisting of a bony horncore covered with a layer of skin and then a sheath of keratinous material showing variability of growth intensity based on nutrition. From the point of view of the horn's mechanical properties, the keratin sheath has been widely studied, but only a few studies have considered the complete structure of the horn and fewer studies have focused on the bony horncore and its characteristics. The latter showed the important role of the bony core, when cranial appendages are subject to mechanical stress (as happens during fighting)...
October 10, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29021829/review-article-effects-of-type-2-diabetes-therapies-on-bone-metabolism
#7
REVIEW
A G D Vianna, C P Sanches, F C Barreto
Diabetes complications and osteoporotic fractures are two of the most important causes of morbidity and mortality in older patients, and they share many features, including genetic susceptibility, molecular mechanisms, and environmental factors. Type 2 diabetes mellitus (T2DM) compromises bone microarchitecture by inducing abnormal bone cell function and matrix structure with increased osteoblast apoptosis, diminished osteoblast differentiation, and enhanced osteoclast-mediated bone resorption. The linkage between these two chronic diseases creates a possibility that certain antidiabetic therapies may affect bone function...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29020988/haloperidol-affects-bones-while-clozapine-alters-metabolic-parameters-sex-specific-effects-in-rats-perinatally-treated-with-phencyclidine
#8
Tatjana Nikolić, Milan Petronijević, Jelena Sopta, Milica Velimirović, Tihomir Stojković, Gordana Jevtić Dožudić, Milan Aksić, Nevena V Radonjić, Nataša Petronijević
BACKGROUND: The presentation of schizophrenia (SCH) symptoms differs between the sexes. Long-term treatment with antipsychotics is frequently associated with decreased bone mineral density, increased fracture risk and metabolic side effects. Perinatal phencyclidine (PCP) administration to rodents represents an animal model of SCH. The aim of this study was to assess the effects of chronic haloperidol and clozapine treatment on bone mass, body composition, corticosterone, IL-6 and TNF-α concentrations and metabolic parameters in male and female rats perinatally treated with PCP...
October 11, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29019343/the-association-between-dietary-inflammatory-properties-and-bone-mineral-density-and-risk-of-fracture-in-us-adults
#9
M Mazidi, N Shivappa, M D Wirth, J R Hebert, H Vatanparast, A P Kengne
BACKGROUND/OBJECTIVES: To examine the associations of dietary inflammatory index (DII) with bone mineral density (BMD) and fracture risk in adult Americans.Subjects/Method:The United States National Health and Nutrition Examination Survey participants during 2005-2010 were included if they had measured data on dietary intake and BMD. DII scores were calculated from estimated micro- and macronutrients from a single 24-h dietary recall. BMD was measured using dual-energy X-ray absorptiometry densitometers...
October 11, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29018903/clinical-significance-of-dxa-and-hr-pqct-in-autosomal-dominant-osteopetrosis-ado-ii
#10
Sebastian Butscheidt, Tim Rolvien, Uwe Kornak, Felix N Schmidt, Thorsten Schinke, Michael Amling, Ralf Oheim
The main hallmark of high bone mass (HBM) disorders is increased bone mineral density, potentially visible in conventional radiographs and quantifiable by other radiographic methods. While one of the most common forms of HBM is CLCN7-related autosomal dominant osteopetrosis type II (ADO II), there is no consensus on diagnostic thresholds. We therefore wanted to assess whether CLCN7-osteopetrosis patients differ from benign HBM cases in terms of (1) bone mineral density, (2) bone structure, and (3) microarchitectural abnormalities...
October 10, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29018897/lack-of-evidence-that-soluble-urate-directly-influences-bone-remodelling-a-laboratory-and-clinical-study
#11
Nicola Dalbeth, Bregina Pool, Ashika Chhana, Jian-Ming Lin, Mei Lin Tay, Paul Tan, Karen E Callon, Dorit Naot, Anne Horne, Jill Drake, Gregory D Gamble, Ian R Reid, Andrew Grey, Lisa K Stamp, Jillian Cornish
INTRODUCTION: Numerous observational studies have reported that serum urate concentration positively correlates with bone density and reduced risk of fractures. The aim of this study was to examine whether soluble urate directly influences bone remodelling. METHODS: In laboratory studies, the in vitro effects of soluble urate were examined in osteoclast, osteoblast and osteocyte assays at a range of urate concentrations consistent with those typically observed in humans (up to 0...
October 10, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29018567/do-we-need-bone-mineral-density-to-estimate-osteoporotic-fracture-risk-a-10-year-prospective-multicentre-validation-study
#12
Andréa Marques, Raquel Lucas, Eugénia Simões, Suzanne M M Verstappen, Johannes W G Jacobs, Jose A P da Silva
OBJECTIVE: Evaluate the performance of FRAX®, with and without bone mineral densitometry (BMD), in predicting the occurrence of fragility fractures over 10 years. METHODS: Participants aged ≥40 years at baseline, with a complete set of data and a minimum of 8.5 years of follow-up were identified from three cohorts (n=2626). Ten-year fracture risk at baseline were estimated with FRAX® and assessed by comparison with observed fractures and receiver operating characteristic analysis...
2017: RMD Open
https://www.readbyqxmd.com/read/28993955/the-c-29t-c-polymorphism-of-the-transforming-growth-factor-beta-1-tgfb1-gene-bone-mineral-density-and-the-occurrence-of-low-energy-fractures-in-patients-with-inflammatory-bowel-disease
#13
I Krela-Kaźmierczak, M Michalak, A Wawrzyniak, A Szymczak, P Eder, L Łykowska-Szuber, M Kaczmarek-Ryś, N Drwęska-Matelska, M Skrzypczak-Zielińska, K Linke, R Słomski
Gastrointestinal tract conditions are frequently associated with low bone mineral density and increased risk of fractures due to osteoporosis, the latter concerning particularly inflammatory bowel disease (IBD) patients. One of the candidate genes involved in osteoporosis is the transforming growth factor beta-1 (TGFB1) whose polymorphisms may be responsible for the development of this disease. The aim of this study was to analyse the frequency of TGFB1 polymorphic variants and determine the association between the c...
October 9, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28993862/utilization-of-bone-mineral-density-testing-among-breast-cancer-survivors-in-british-columbia-canada
#14
O L Tseng, M G Dawes, J J Spinelli, C C Gotay, M L McBride
Breast cancer survivors are at high osteoporosis risk. Bone mineral density testing plays a key role in osteoporosis management. We analyzed a historical utilization of bone mineral density testing in breast cancer survivors. The utilization remained low in the 1995-2008 period. Lower socio-economic status and rural residency were associated with lower utilization. INTRODUCTION: To evaluate the utilization of bone mineral density (BMD) testing for female breast cancer survivors aged 65+ surviving ≥ 3 years in British Columbia, Canada...
October 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28993002/recovery-patterns-over-4-years-after-distal-radius-fracture-descriptive-changes-in-fracture-specific-pain-disability-fall-risk-factors-bone-mineral-density-and-general-health-status
#15
Neha Dewan, Joy C MacDermid, Ruby Grewal, Karen Beattie
STUDY DESIGN: Descriptive/Longitudinal cohort. INTRODUCTION: Distal radius fracture (DRF) is a common fall related fragility fracture that is known to be an early and independent predictor of secondary osteoporotic (OP) fractures. Changes in falls risk status, bone status and general health has not been evaluated prospectively in a population that has sustained a DRF. PURPOSE OF THE STUDY: The purpose of our study was to describe the status of fracture-specific pain/disability, fall risk factors such as physical activity (PA) and fear of falling (FOF), bone mineral density (BMD) and general health status (HS) in people with a DRF and how these variables change over four years with respect to sex, age, incidence of secondary falls and secondary OP fractures...
October 6, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28991829/sepsis-reduces-bone-strength-before-morphologic-changes-are-identifiable
#16
Zudin A Puthucheary, Yao Sun, Kaiyang Zeng, Lien Hong Vu, Zhi Wei Zhang, Ryan Z L Lim, Nicholas S Y Chew, Matthew E Cove
OBJECTIVES: Survivors of critical illness have an increased prevalence of bone fractures. However, early changes in bone strength, and their relationship to structural changes, have not been described. We aimed to characterize early changes in bone functional properties in critical illness and their relationship to changes in bone structure, using a sepsis rodent model. DESIGN: Experimental study. SETTING: Animal research laboratory. SUBJECTS: Adult Sprague-Dawley rats...
October 6, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28988680/macroscopic-anisotropic-bone-material-properties-in-children-with-severe-osteogenesis-imperfecta
#17
Carolyne Albert, John Jameson, Sergey Tarima, Peter Smith, Gerald Harris
Children with severe osteogenesis imperfecta (OI) typically experience numerous fractures and progressive skeletal deformities over their lifetime. Recent studies proposed finite element models to assess fracture risk and guide clinicians in determining appropriate intervention in children with OI, but lack of appropriate material property inputs remains a challenge. This study aimed to characterize macroscopic anisotropic cortical bone material properties and investigate relationships with bone density measures in children with severe OI...
September 14, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28988216/efficacy-and-treatment-costs-of-zoledronate-versus-pamidronate-in-paediatric-osteoporosis
#18
Vrinda Saraff, Jaskiran Sahota, Nicola Crabtree, Sophia Sakka, Nicholas J Shaw, Wolfgang Högler
Intravenous pamidronate has been used in the treatment of osteogenesis imperfecta (OI) in children for over 20 years. The more potent zoledronate is an attractive alternative as it is administered less frequently. This study compares the clinical efficacy of intravenous pamidronate (1.5 mg/kg/day over 2 days, every 3 months) versus zoledronate (0.05 mg/kg/dose every 6 months) in 40 children (20 per group) with mild to moderate OI and the treatment costs of the two drugs in a tertiary centre for children with osteoporosis...
October 7, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28982680/chronic-psychosocial-stress-disturbs-long-bone-growth-in-adolescent-mice
#19
S Foertsch, M Haffner-Luntzer, J Kroner, F Gross, K Kaiser, M Erber, S O Reber, A Ignatius
Although a strong association between psychiatric and somatic disorders is generally accepted, little is known regarding the interrelation between mental and skeletal health. While depressive disorders were shown to be strongly associated with osteoporosis and increased fracture risk, evidence from post-traumatic stress disorder (PTSD) patients is less consistent. Therefore, the present study investigated the influence of chronic psychosocial stress on bone using a well-established murine model for PTSD. 7-week-old C57BL/6N mice were subjected to chronic subordinate colony housing (CSC) for 19 days, whereas control mice were singly housed...
October 5, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28979590/hiv-infection-and-bone-abnormalities
#20
Aamir N Ahmad, Shahid N Ahmad, Nafees Ahmad
More than 36 million people are living with human immunodeficiency virus (HIV) infection worldwide and 50% of them have access to antiretroviral therapy (ART). While recent advances in HIV therapy have reduced the viral load, restored CD4 T cell counts and decreased opportunistic infections, several bone-related abnormalities such as low bone mineral density (BMD), osteoporosis, osteopenia, osteomalacia and fractures have emerged in HIV-infected individuals. Of all classes of antiretroviral agents, HIV protease inhibitors used in ART combination showed a higher frequency of osteopenia, osteoporosis and low BMD in HIV-infected patients...
2017: Open Orthopaedics Journal
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