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JOURNAL ARTICLE
José Kennedy Amaral, Peter Charles Taylor, Robert Taylor Schoen
BACKGROUND: Chikungunya fever is an emerging global infection transmitted by Aedes mosquitoes that manifests as an acute febrile illness with joint pain and can lead to chronic arthritis. The mechanism underlying chronic joint damage remains unclear; however, chronic chikungunya arthritis shares similarities with rheumatoid arthritis. Disease-modifying antirheumatic drugs have revolutionized rheumatoid arthritis treatment by preventing joint damage. However, the role of these therapies in chronic chikungunya arthritis has not been determined...
2024: Revista da Sociedade Brasileira de Medicina Tropical
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JOURNAL ARTICLE
Filipe de Neri Machado, Anthony D K Draper, Anferida Monteiro Fernandes, Frederico Bosco Alves Dos Santos, Marcelo Amaral Mali, Ari J Pereira Tilman, Endang Soares da Silva, Elizabeth Hornay, Antonio Salles de Sousa, Tessa Oakley, Edinha da Cruz, Nevio Sarmento, Maria A V Niha, Ana Fatima Soares, Eva Estrelita Cardoso Gomes, Jose de Deus Alves, Jose Paulo Soares, Joshua R Francis, Jennifer Yan, Merita Antonio Monteiro
Timor-Leste is a mountainous, half-island nation with a population of 1.3 million, which shares a land border with Indonesia and is 550 km from Darwin, Australia. Since independence in 2002, Timor-Leste has achieved significant development; however, high levels of poverty remain. Chikungunya virus (CHIKV) is endemic in over 100 countries in Africa, Asia, Europe and in the Americas. It is transmitted by the bite of infected Aedes aegypti or Ae. albopictus mosquitoes, which are present in Timor-Leste and which contribute to annual rainy-season dengue virus (DENV) outbreaks...
April 10, 2024: Communicable Diseases Intelligence
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JOURNAL ARTICLE
Rajendra Prasad Chatterjee, Aroni Chatterjee, Sabbir Ansari, Shilpa Chatterjee, Shyamalendu Chatterjee, Nilanjan Chakraborty
Dengue and chikungunya are co-circulating vector-borne diseases that share a significant number of clinical symptoms. To identify variables to aid physicians in making rapid and effective diagnostic decisions, we performed molecular diagnosis of the chikungunya virus and examined the clinical manifestations of chikungunya cases to identify the prevalence among dengue-negative individuals in Kolkata. Dengue suspected patients' samples were collected during January 2020-December 2021 and Enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR) methods have been performed to confirm the prevalence of chikungunya infection among dengue-negative patients...
2024: PloS One
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JOURNAL ARTICLE
Aileen Y Chang, Sarah R Tritsch, Carlos Andres Herrera Gomez, Liliana Encinales, Andres Cadena Bonfanti, Wendy Rosales, Evelyn Mendoza-Torres, Samuel Simmens, Richard L Amdur, Christopher N Mores, Paige Fierbaugh, Carlos Alberto Perez Hernandez, Geraldine Avendaño, Paula Bruges Silvera, Yerlenis Galvis Crespo, Alberto David Cabana Jimenez, Jennifer Carolina Martinez Zapata, Dennys Jimenez, Estefanie Osorio-Llanes, Jairo Castellar-Lopez, Karol Suchowiecki, Karen Martins, Melissa Gregory, Ivan Zuluaga, Abigale Proctor, Alfonso Sucerquia Hernández, Leandro Sierra-Carrero, Maria Villanueva Colpas, Juan Carlos Perez Hernandez, Andres Alberto Figueroa Quast, Joaquin Andres Calderon De Barros, José Forero Mejía, Johan Penagos Ruiz, David Boyle, Gary S Firestein, Gary L Simon
OBJECTIVE: To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy. METHODS: Participants with chikungunya arthritis were recruited from Colombia from 2019-2021. Arthritis disease severity was quantified using the Disease Activity Score-28 and an Arthritis-Flare Questionnaire adapted for chikungunya arthritis. Plasma cytokine concentrations (interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ and tumor necrosis factor (TNF)) were measured using a Meso Scale Diagnostics assay...
2024: PloS One
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JOURNAL ARTICLE
Antônio Felipe Lopes Cavalcante, Joanna Sacha Cunha Brito Holanda, João Octávio Sales Passos, Joyce Maria Pereira de Oliveira, Edgard Morya, Alexandre H Okano, Marom Bikson, Rodrigo Pegado
BACKGROUND: Chikungunya virus (CHIKV) is a globally prevalent pathogen, with outbreaks occurring in tropical regions. Chronic pain is the main symptom reported and is associated with decreased mobility and disability. Transcranial direct current stimulation (tDCS) is emerging as a new therapeutic tool for chronic arthralgia. OBJECTIVE: To evaluate the effectiveness of 10 consecutive sessions of anodal tDCS on pain (primary outcome) in participants with chronic CHIKV arthralgia...
March 12, 2024: Annals of Physical and Rehabilitation Medicine
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JOURNAL ARTICLE
Ximena Flandes, Clairissa A Hansen, Sunil Palani, Kaja Abbas, Cate Bennett, William Perea Caro, Raymond Hutubessy, Kanat Khazhidinov, Philipp Lambach, Clara Maure, Caroline Marshall, Diana P Rojas, Alexander Rosewell, Sushant Sahastrabuddhe, Marta Tufet, Annelies Wilder-Smith, David W C Beasley, Nigel Bourne, Alan D T Barrett
Chikungunya virus (CHIKV) a mosquito-borne alphavirus is the causative agent of Chikungunya (CHIK), a disease with low mortality but high acute and chronic morbidity resulting in a high overall burden of disease. After the acute disease phase, chronic disease including persistent arthralgia is very common, and can cause fatigue and pain that is severe enough to limit normal activities. On average, around 40% of people infected with CHIKV will develop chronic arthritis, which may last for months or years. Recommendations for protection from CHIKV focus on infection control through preventing mosquito proliferation...
November 7, 2023: Vaccine
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JOURNAL ARTICLE
Rafaela Dos S Peinado, Lucas G Martins, Carolina C Pacca, Marielena V Saivish, Kelly C Borsatto, Maurício L Nogueira, Ljubica Tasic, Raghuvir K Arni, Raphael J Eberle, Mônika A Coronado
The arbovirus Chikungunya (CHIKV) is transmitted by Aedes mosquitoes in urban environments, and in humans, it triggers debilitating symptoms involving long-term complications, including arthritis and Guillain-Barré syndrome. The development of antiviral therapies is relevant, as no efficacious vaccine or drug has yet been approved for clinical application. As a detailed map of molecules underlying the viral infection can be obtained from the metabolome, we validated the metabolic signatures of Vero E6 cells prior to infection (CC), following CHIKV infection (CV) and also upon the inclusion of the nsP2 protease inhibitor wedelolactone (CWV), a coumestan which inhibits viral replication processes...
January 24, 2024: International Journal of Molecular Sciences
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REVIEW
Thales Augusto Anestino, Celso Martins Queiroz-Junior, Amanda Medeiros Frota Cruz, Daniele G Souza, Mila Fernandes Moreira Madeira
Arthritis and periodontitis are inflammatory diseases that share several immunopathogenic features. The expansion in the study of virus-induced arthritis has shed light on how this condition could impact other parts of the human body, including the mouth. Viral arthritis is an inflammatory joint disease caused by several viruses, most notably the alphaviruses Chikungunya virus (CHIKV), Sindbis virus (SINV), Ross River virus (RRV), Mayaro virus (MAYV), and O'nyong'nyong virus (ONNV). These viruses can induce an upsurge of matrix metalloproteinases and immune-inflammatory mediators such as Interleukin-6 (IL6), IL-1β, tumor necrosis factor, chemokine ligand 2, and receptor activator of nuclear factor kappa-B ligand in the joint and serum of infected individuals...
February 1, 2024: Journal of Applied Microbiology
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REVIEW
Camila C S Caetano, Tamiris Azamor, Nikki M Meyer, Chineme Onwubueke, Cassandra M Calabrese, Leonard H Calabrese, Anabelle Visperas, Nicolas S Piuzzi, M Elaine Husni, Suan-Sin Foo, Weiqiang Chen
Bone-related diseases (osteopathologies) associated with human virus infections have increased around the globe. Recent findings have highlighted the intricate interplay between viral infection, the host immune system and the bone remodelling process. Viral infections can disrupt bone homeostasis, contributing to conditions such as arthritis and soft tissue calcifications. Osteopathologies can occur after arbovirus infections such as chikungunya virus, dengue virus and Zika virus, as well as respiratory viruses, such as severe acute respiratory syndrome coronavirus 2 and enteroviruses such as Coxsackievirus B...
February 2024: Nature Microbiology
#10
Yesica Lamberto, Pablo Saul, Susana Caceres, Milagro Sánchez Cunto, Viviana Chediack, Eleonora Cunto
Chikungunya virus is an Alphavirus, it belongs to the family Togaviridae and is transmitted by mosquitoes. It was first described during an outbreak in Southern Tanzania in 1952. It generally causes a febrile syndrome, accompanied by joint pain and arthritis, which is often debilitating and may persist for months or years. Its overall fatality rate is not high, around 0.1%. Atypical and severe cases have been reported. This virus has been detected in more than 110 countries globally. In Northeastern Brazil autochthonous cases have been diagnosed since September 2014...
2024: Medicina
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JOURNAL ARTICLE
Rudra Narayan Dash, Amrita Ray, Prabhudutta Mamidi, Saikat De, Tapas K Mohapatra, Alok K Moharana, Tathagata Mukherjee, Soumyajit Ghosh, Subhasis Chattopadhyay, Bharat B Subudhi, Soma Chattopadhyay
There is no approved antiviral for the management of the Chikungunya virus (CHIKV). To develop an antiviral drug that can manage both CHIKV and arthritis induced by it, an ester conjugate of telmisartan (TM) and salicylic acid (SA) was synthesized (DDABT1). It showed higher potency (IC50 of 14.53 μM) and a good selectivity index [(SI = CC50 /IC50 ) > 33]. On post-treatment of DDABT1, CHIKV infection was inhibited significantly by reducing CPE, viral titer, viral RNA, and viral proteins. Further, the time of addition experiment revealed >95% inhibition up to 4hpi indicating its interference predominantly in the early stages of infection...
January 9, 2024: ACS Omega
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JOURNAL ARTICLE
Rachel Bierbrier, Emilie Javelle, Francesca F Norman, Lin Hwei Chen, Emmanuel Bottieau, Eli Schwartz, Karin Leder, Kristina M Angelo, Rhett Stoney, Michael Libman, Davidson H Hamer, Ralph Huits, Bradley A Connor, Fabrice Simon, Sapha Barkati
BACKGROUND: Chikungunya is an important travel-related disease because of its rapid geographical expansion and potential for prolonged morbidity. Improved understanding of the epidemiology of travel-related chikungunya infections may influence prevention strategies including education and vaccination. METHODS: We analysed data from travellers with confirmed or probable chikungunya reported to GeoSentinel sites from 2005 to 2020. Confirmed chikungunya was defined as a compatible clinical history plus either virus isolation, positive nucleic acid test, or seroconversion/rising titre in paired sera...
January 9, 2024: Journal of Travel Medicine
#13
José Kennedy Amaral, Gabriela Lucena, Robert Taylor Schoen
BACKGROUND: Chikungunya fever is a reemerging epidemic disease caused by a single-stranded RNA alphavirus transmitted throughout by Aedes mosquitoes. Chikungunya virus infection is a biphasic disease in which 72% to 95% of affected individuals manifest acute chikungunya fever. Following the acute phase, more than 40% of affected individuals develop arthritis, often lasting more than 3 months, referred to as chronic chikungunya arthritis, which frequently mimics rheumatoid arthritis. OBJECTIVE: This study aimed to evaluate the efficacy and safety of treatment of chronic chikungunya arthritis with methotrexate and dexamethasone in a randomized, double-blind, placebo-controlled clinical trial...
January 2, 2024: Current Rheumatology Reviews
#14
REVIEW
Jobson Lopes de Oliveira, Igor Albuquerque Nogueira, J Kennedy Amaral, Luciana Ribeiro Campos, Mariana Macêdo Militão Mendonça, Marília de Brito Ricarte, Luciano Pamplona de Góes Cavalcanti, Robert T Schoen
Chikungunya fever (CHIK) is a neglected tropical disease associated with chronic arthritis. CHIK is usually a self-limiting condition; however, extra-articular manifestations present as atypical illness in a minority of patients. These atypical features may mimic other conditions and potentially distract physicians from the true diagnosis. This review analyzes the evidence of many unusual extra-articular manifestations reported in cases of CHIK. Depending on the affected system, these unusual manifestations include encephalitis, myocarditis, acute interstitial nephritis, cutaneous manifestations, acute anterior uveitis, abdominal pain, and depression...
2023: Revista da Sociedade Brasileira de Medicina Tropical
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JOURNAL ARTICLE
Nitika Gaurav, Shivani Kumar, Siva Raghavendhar, Praveen Kumar Tripathi, Shipra Gupta, Ravi Arya, Ashok Kumar Patel
Chikungunya virus (CHIKV) causes persistent arthritis and neurological problems imposing a huge burden globally. The present study aims to understand the interaction mechanism of Chikungunya virus and CHIKV-capsid in Huh7 cells. The RNA-sequencing and qRT-PCR method was used for the transcript and gene profiles of CHIKV virus and CHIKV capsid alone. Transcriptional analysis showed capsid induced 1114 and 956 differentially expressed genes (DEGs) to be upregulated and downregulated respectively, while in virus, 933 genes were upregulated and 956 were downregulated...
November 28, 2023: Virology
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JOURNAL ARTICLE
Amrita Saha, Badri Narayan Acharya, Manmohan Parida, Nandita Saxena, Jaya Rajaiya, Paban Kumar Dash
Alphaviruses are serious zoonotic threats responsible for significant morbidity, causing arthritis or encephalitis. So far, no licensed drugs or vaccines are available to combat alphaviral infections. About 300,000 chikungunya virus (CHIKV) infections have been reported in 2023, with more than 300 deaths, including reports of a few cases in the USA as well. The discovery and development of small-molecule drugs have been revolutionized over the last decade. Here, we employed a cell-based screening approach using a series of in-house small-molecule libraries to test for their ability to inhibit CHIKV replication...
October 31, 2023: Viruses
#17
JOURNAL ARTICLE
Churnalisa Doran, Ashley Duits, Izzy Gerstenbluth, Adriana Tami, Ajay Bailey
BACKGROUND: Long-term chikungunya disease, characterized by persistent disabling rheumatic symptoms, including poly-arthralgia/arthritis of severe pain intensity, can persist for years after infection with the re-emerging mosquito-borne chikungunya virus. Although persistent symptoms and pain severity are important determinants of health-care seeking and self-management of symptoms, research on these in relation to long-term chikungunya disease is scarce. This study aimed to explore the perceived benefits and perceived barriers concerning health-care seeking, based on the Health Belief Model, and the symptoms self-management strategies used for health outcome improvement among individuals affected by long-term chikungunya disease...
November 13, 2023: BMC Health Services Research
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JOURNAL ARTICLE
Wern Hann Ng, Xiang Liu, Zheng L Ling, Camilla N O Santos, Lucas S Magalhães, Andrew J Kueh, Marco J Herold, Adam Taylor, Joseph R Freitas, Sandra Koit, Sainan Wang, Andrew R Lloyd, Mauro M Teixeira, Andres Merits, Roque P Almeida, Nicholas J C King, Suresh Mahalingam
Arthritogenic alphaviruses are positive-strand RNA viruses that cause debilitating musculoskeletal diseases affecting millions worldwide. A recent discovery identified the four-and-a-half-LIM domain protein 1 splice variant A (FHL1A) as a crucial host factor interacting with the hypervariable domain (HVD) of chikungunya virus (CHIKV) nonstructural protein 3 (nsP3). Here, we show that acute and chronic chikungunya disease in humans correlates with elevated levels of FHL1. We generated FHL1-/- mice, which when infected with CHIKV or o'nyong-nyong virus (ONNV) displayed reduced arthritis and myositis, fewer immune infiltrates, and reduced proinflammatory cytokine/chemokine outputs, compared to infected wild-type (WT) mice...
October 26, 2023: Nature Communications
#19
JOURNAL ARTICLE
Van Cao, Naphat Loeanurit, Kowit Hengphasatporn, Rita Hairani, Noppadol Wacharachaisurapol, Nantaporn Prompila, Supeecha Wittayalertpanya, Yasuteru Shigeta, Tanatorn Khotavivattana, Warinthorn Chavasiri, Siwaporn Boonyasuppayakorn
Chikungunya virus is a re-emerging arbovirus that has caused epidemic outbreaks in recent decades. Patients in older age groups with high viral load and severe immunologic response during acute infection are likely to develop chronic arthritis and severe joint pain. Currently, no antiviral drug is available. Previous studies suggested that a flavone derivative, 8-bromobaicalein, was a potential dengue and Zika replication inhibitor in a cell-based system targeting flaviviral polymerase. Here we characterized that 8-bromobaicalein inhibited chikungunya virus replication with EC50 of 0...
October 16, 2023: Emerging Microbes & Infections
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JOURNAL ARTICLE
Maíra Sant Anna Genaro de Brito, Micheli Said de Marchi, Matheus Yung Perin, Isabelle da Silva Côsso, Renan Urt Mansur Bumlai, Waldemar Vaz da Silva Júnior, Adriana Yuki Mello Prado, Thais Campos Dias da Cruz, Eudes Thiago Pereira Avila, Amílcar Sabino Damazo, Renata Dezengrini Slhessarenko
INTRODUCTION: Chikungunya chronic joint disease causes debilitating arthralgia, significantly impacting the quality of life of affected individuals. METHODS: In this study, patients underwent clinical follow-ups, joint biopsies, and pre-biopsy and 24 months post-biopsy serum dosage of cytokines. RESULTS: All participants were female and had pain in 12 joints on average, with 41.17% exhibiting moderate disease activity. Histopathological analysis revealed collagen deposition...
2023: Revista da Sociedade Brasileira de Medicina Tropical
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