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chikungunya arthritis

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https://www.readbyqxmd.com/read/29747994/a-systematic-review-of-viral-exposures-as-a-risk-for-rheumatoid-arthritis
#1
F M Kudaeva, M R Speechley, J E Pope
OBJECTIVE: Different viral exposures have been implicated in the etiology of rheumatoid arthritis (RA). Evidence relating to the association between putative viral exposures and the development of RA was reviewed. METHODS: A systematic literature search was conducted using MEDLINE-OVID, EMBASE-OVID, PUBMED and Cochrane library databases. Articles were included if they were case-controls, cross-sectional or cohort studies and were published in English. Case-series were included if there was a lack of other study designs...
March 21, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29709007/chikungunya-virus-infection-in-aruba-diagnosis-clinical-features-and-predictors-of-post-chikungunya-chronic-polyarthralgia
#2
Ralph Huits, Jaclyn De Kort, Riemsdijk Van Den Berg, Luis Chong, Achilleas Tsoumanis, Kaat Eggermont, Koen Bartholomeeusen, Kevin K Ariën, Jan Jacobs, Marjan Van Esbroeck, Emmanuel Bottieau, Lieselotte Cnops
BACKGROUND: Chikungunya virus (CHIKV) emerged in Aruba for the first time in 2014. We studied the clinical presentation of acute CHIKV infection and the contribution of serologic and molecular assays to its diagnosis. In a cohort of confirmed CHIKV cases, we analysed the frequency, duration and predictors of post-chikungunya chronic polyarthralgia (pCHIK-CPA), defined as joint pains lasting longer than 6 weeks or longer than 1 year. METHODOLOGY: Patient sera obtained within 10 days of symptom onset were tested for CHIKV, using an indirect immunofluorescence test for the detection of CHIKV-specific Immunoglobulin M (IgM) and post-hoc, by reverse-transcription polymerase chain reaction (RT-PCR)...
2018: PloS One
https://www.readbyqxmd.com/read/29702546/mutation-of-cd2ap-and-sh3kbp1-binding-motif-in-alphavirus-nsp3-hypervariable-domain-results-in-attenuated-virus
#3
Margit Mutso, Ainhoa Moliner Morro, Cecilia Smedberg, Sergo Kasvandik, Muriel Aquilimeba, Mona Teppor, Liisi Tarve, Aleksei Lulla, Valeria Lulla, Sirle Saul, Bastian Thaa, Gerald M McInerney, Andres Merits, Margus Varjak
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus replicase. These proteins also interact with numerous host proteins and some crucial interactions are mediated by the unstructured C-terminal hypervariable domain (HVD) of nsP3. In this study, a human cell line expressing EGFP tagged with CHIKV nsP3 HVD was established...
April 27, 2018: Viruses
https://www.readbyqxmd.com/read/29581442/a-vaccinia-based-single-vector-construct-multi-pathogen-vaccine-protects-against-both-zika-and-chikungunya-viruses
#4
Natalie A Prow, Liang Liu, Eri Nakayama, Tamara H Cooper, Kexin Yan, Preethi Eldi, Jessamine E Hazlewood, Bing Tang, Thuy T Le, Yin Xiang Setoh, Alexander A Khromykh, Jody Hobson-Peters, Kerrilyn R Diener, Paul M Howley, John D Hayball, Andreas Suhrbier
Zika and chikungunya viruses have caused major epidemics and are transmitted by Aedes aegypti and/or Aedes albopictus mosquitoes. The "Sementis Copenhagen Vector" (SCV) system is a recently developed vaccinia-based, multiplication-defective, vaccine vector technology that allows manufacture in modified CHO cells. Herein we describe a single-vector construct SCV vaccine that encodes the structural polyprotein cassettes of both Zika and chikungunya viruses from different loci. A single vaccination of mice induces neutralizing antibodies to both viruses in wild-type and IFNAR-/- mice and protects against (i) chikungunya virus viremia and arthritis in wild-type mice, (ii) Zika virus viremia and fetal/placental infection in female IFNAR-/- mice, and (iii) Zika virus viremia and testes infection and pathology in male IFNAR-/- mice...
March 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/29561944/treatment-of-chikungunya-chronic-arthritis-a-systematic-review
#5
REVIEW
Gabriella Maria Pitt Gameiro Sales, Izabel Crystine Pereira Barbosa, Laura Maia Sampaio Canejo Neta, Paloma Lopes de Melo, Raphael de Azevedo Leitão, Hugo Moura de Albuquerque Melo
INTRODUCTION: Chikungunya (CHIK) is a tropical arbovirus, transmitted by the female mosquito Aedes aegypti and Aedes albopictus. In Brazil, there have been cases reported since 2014. The initial manifestations of this virus are sudden onset high fever, headache, chills, rashes, myalgia and intense joint pain. Usually, CHIK presents the acute and chronic phases, the latter characterized by bilateral polyarthralgia, which can last for months or even years. During this period, autoimmune diseases can be triggered, making the picture even more complicated...
January 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29536378/a-case-report-of-chikungunya-fever-rheumatoid-arthritis-and-felty-s-syndrome
#6
José Kennedy Amaral, Robert T Schoen
INTRODUCTION: Chronic chikungunya (CHIK) arthritis, an inflammatory arthritis, often follows acute CHIK fever (CHIKF), a viral infection. The pathogenesis of chronic CHIK arthritis is poorly characterized, but may resemble other forms of inflammatory arthritis. Clinically, chronic CHIK arthritis sometimes mimics rheumatoid arthritis (RA). CASE REPORT: We report a patient with well-characterized CHIKF followed 2 months later by chronic CHIK arthritis not only resembling RA clinically, but also associated with RA biomarkers and extra-articular features, including Felty's syndrome (FS)...
June 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29533749/chikungunya-virus-a-rheumatologist-s-perspective
#7
REVIEW
Marta Runowska, Dominik Majewski, Karolina Niklas, Mariusz Puszczewicz
Chikungunya virus (CHIKV) is an arthropod-borne alphavirus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes. It is responsible for a febrile illness, typically accompanied by maculopapular rash and severe, incapacitating arthralgia. The disease, although generally self-limiting, frequently evolves into a long-lasting, debilitating rheumatic disorder, which shares many clinical features with rheumatoid arthritis (RA). The underlying mechanism by which CHIKV induces persistent arthritis remains under investigation, however, currently, attention is drawn to the fact, that chronic chikungunya (CHIK) and RA have many common cellular and cytokine pathways involved in their pathogenesis...
March 2, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29513923/reply
#8
LETTER
Aileen Y Chang, Jeffrey M Bethony, Gary L Simon, Liliana Encinales
No abstract text is available yet for this article.
March 7, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29467856/smoking-and-female-sex-as-key-risk-factors-associated-with-severe-arthralgia-in-acute-and-chronic-phases-of-chikungunya-virus-infection
#9
Ivan Delgado-Enciso, Brenda Paz-Michel, Valery Melnikov, Jose Guzman-Esquivel, Francisco Espinoza-Gomez, Alejandro D Soriano-Hernandez, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Gabriel Ceja-Espiritu, Bertha A Olmedo-Buenrostro, Hector R Galvan-Salazar, Osiris G Delgado-Enciso, Josuel Delgado-Enciso, Uriel A Lopez-Lemus, Daniel A Montes-Galindo
Arthralgia is a potentially incapacitating condition and a persistent symptom in chronic or acute episodes of Chikungunya fever caused by infection with the Chikungunya virus (CHIKV). To the best of our knowledge, there are no reports on risk factors associated with the intensity of arthralgias in typical acute episodes of the disease. Although a number of studies have reported on risk factors associated with the development of the chronic stage of the disease, smoking habits have not been analyzed. Smoking is an interesting factor to consider since it is the main environmental risk factor for the development of rheumatoid arthritis (RA), a similar disease to CHIKV in many aspects...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29431292/chikungunya-a-rheumatologist-s-perspective
#10
REVIEW
Shefali Khanna Sharma, Sanjay Jain
Chikungunya (CHIK), a viral infection, is transmitted by Aedes mosquitoes. It is characterized by a phase of acute infection, which is sometimes followed by chronic rheumatisim in the form of arthralgia or myalgia that can last for months and even years. Several studies have been conducted to understand the mechanisms underlying inflammation associated with CHIK infection, persistence of viruses in monocytes-macrophages, and their relationship to the chronic symptoms. Chronic arthritis is one of the serious complications of CHIK infection, which is characterized by swelling and acute pain that poorly responds to treatment with analgesics...
March 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29416137/acute-inflammatory-arthritis-methotrexate-for-chronic-chikungunya-arthritis
#11
Sarah Onuora
No abstract text is available yet for this article.
March 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29389830/emergence-and-treatment-of-chikungunya-arthritis
#12
Ravi B Sutaria, Jose K Amaral, Robert T Schoen
PURPOSE OF REVIEW: To review the emergence, clinical features, pathogenesis, and treatment of acute chikungunya (CHIK) fever and chronic CHIK arthritis. RECENT FINDINGS: Since 2004, CHIK, an arboviral infection, has spread throughout the world, infecting millions of people. The illness occurs in two phases: an acute viremic infection followed by chronic arthritis. In less developed countries, there are limited resources and effective treatment. For acutely ill CHIK fever patients, management is symptomatic...
May 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29362462/acute-inflammatory-arthritis-long-term-effects-of-chikungunya
#13
Jessica McHugh
No abstract text is available yet for this article.
January 24, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29361202/treatment-of-chronic-chikungunya-arthritis-with-methotrexate-a-systematic-review
#14
J Kennedy Amaral, Ravi Sutaria, Robert T Schoen
OBJECTIVES: Chikungunya is a rapidly emerging, global viral infection that can cause chronic, debilitating arthritis that in some ways mimics rheumatoid arthritis. This study evaluated the available evidence of the efficacy and safety of methotrexate (MTX), a therapy widely used in rheumatoid arthritis, in the treatment of chronic chikungunya arthritis. METHODS: A systematic literature search was performed to identify all published trials that evaluated MTX as monotherapy or combination therapy in chronic chikungunya arthritis...
January 23, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29339224/emerging-souvenirs-clinical-presentation-of-the-returning-traveller-with-imported-arbovirus-infections-in-europe
#15
I Eckerle, V T Briciu, Ö Ergönül, M Lupşe, A Papa, A Radulescu, S Tsiodras, C Tsitou, C Drosten, V R Nussenblatt, C B Reusken, L A Sigfrid, N J Beeching
BACKGROUND: Arboviruses are an emerging group of viruses that are causing increasing health concerns globally, including in Europe. Clinical presentation usually consists of a nonspecific febrile illness that may be accompanied by rash, arthralgia and arthritis, with or without neurological or haemorrhagic syndromes. The range of differential diagnoses of other infectious and noninfectious aetiologies is broad, presenting a challenge for physicians. While knowledge of the geographical distribution of pathogens and the current epidemiological situation, incubation periods, exposure risk factors and vaccination history can help guide the diagnostic approach, the nonspecific and variable clinical presentation can delay final diagnosis...
March 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29287308/chikungunya-arthritis-implications-of-acute-and-chronic-inflammation-mechanisms-on-disease-management
#16
REVIEW
Ali Zaid, Patrick Gérardin, Adam Taylor, Helen Mostafavi, Denis Malvy, Suresh Mahalingam
In the past decade, arboviruses-arthropod-borne viruses-have been the focus of public health institutions worldwide following a spate of devastating outbreaks. Chikungunya virus, an arbovirus that belongs to the alphavirus genus, is a reemerging arthritogenic virus that has caused explosive outbreaks since 2006, notably on Réunion Island, and more recently in the Caribbean, South America, India, and Southeast Asia. The severity of arthritic disease caused by chikungunya virus has prompted public health authorities in affected countries to develop specific guidelines to tackle this pathogen...
April 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29281739/lower-temperatures-reduce-type-i-interferon-activity-and-promote-alphaviral-arthritis
#17
Natalie A Prow, Bing Tang, Joy Gardner, Thuy T Le, Adam Taylor, Yee S Poo, Eri Nakayama, Thiago D C Hirata, Helder I Nakaya, Andrii Slonchak, Pamela Mukhopadhyay, Suresh Mahalingam, Wayne A Schroder, William Klimstra, Andreas Suhrbier
Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthropathy were dramatically reduced when mice were housed at 30°C, rather than the conventional 22°C. The effect was not associated with a detectable fever, but was dependent on type I interferon responses. Bioinformatics analyses of RNA-Seq data after injection of poly(I:C)/jetPEI suggested the unfolded protein response and certain type I interferon responses are promoted when feet are slightly warmer...
December 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29191474/chikungunya-related-erosive-arthritis-case-report-and-literature-review
#18
Francisco Castro-Domínguez, Tarek Carlos Salman-Monte, Fabiola Ojeda, Patricia Corzo, Irene Carrión-Barberá, Ivan Camilo Garcia-Duitama, Jordi Monfort
Chikungunya virus infection (CHIKV) is associated with joint involvement in half of the cases. This can lead to erosive arthritis which, given the high intervariability of clinical and serological presentations, and the probable role of genetic conditioning in the severity and chronification of the condition, represents a great diagnostic and therapeutic challenge. There is an important lack of scientific evidence that would enable us to characterize the variability of the patient and choose the most appropriate approach...
November 27, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29156857/a-study-of-the-chikungunya-virus-in-humans-in-turkey
#19
Tuğba Atalay, Sedat Kaygusuz, Ahmet Kürşat Azkur
Background/aim: The chikungunya virus (CHIKV) is a mosquito-borne disease and has recently been causing explosive outbreaks. The CHIKV has spread throughout all continents. Although the first chikungunya case imported from India to Turkey was reported in 2012, there is no detailed epidemiologic study in Turkey yet. The aim of this study was to investigate the seroprevalence of the CHIKV in Turkey. Materials and methods: ELISA was used to screen 500 random serum samples of healthy people collected from Kırıkkale, which is located in central Anatolia in Turkey...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29149964/chikungunya-infection-in-solid-organ-transplant-recipients
#20
E S Girão, B G Rodrigues Dos Santos, E S do Amaral, P E G Costa, K B Pereira, A H de Araujo Filho, E B Hyppolito, M U Mota, L C B F Marques, C M Costa de Oliveira, S L da Silva, J H P Garcia, P F C B C Fernandes
BACKGROUND: Chikungunya virus (CHIKV) is an emerging mosquito-borne disease that causes acute febrile polyarthralgia and arthritis. CHIKV has spread rapidly to the Americas and, in Brazil, autochthonous cases are increasingly been reported. Solid organ transplant (SOT) recipients who travel to or live in CHIKV endemic areas are under high risk of acquiring the disease. Few data exist regarding the clinical characteristics of CHIKV infections in this population. We report the first case series of CHIKV infection in SOT recipients...
November 2017: Transplantation Proceedings
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