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https://www.readbyqxmd.com/read/26770266/the-potential-utility-of-tight-junction-regulation-in-celiac-disease-focus-on-larazotide-acetate
#1
REVIEW
Shahryar Khaleghi, Josephine M Ju, Abhinav Lamba, Joseph A Murray
Celiac disease (CD) is a common chronic immune disease triggered by gluten. Gliadin peptides pass through the epithelial layers, either paracellularly or transcellularly, to launch a potent adaptive immune response in the lamina propria. This aberrant immune response leads to diverse gastrointestinal and extra-gastrointestinal symptoms. Currently, the only treatment for CD is a strict lifelong adherence to a gluten-free diet (GFD), which can be challenging. An early effect of gluten in CD is an increase in gut permeability...
January 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/25960809/non-dietary-methods-in-the-treatment-of-celiac-disease
#2
REVIEW
Anna Szaflarska-Popławska
This is a selective review of the literature concerning the methods of celiac disease treatment, which can be an alternative to a gluten-free diet. The most advanced studies are devoted to the larazotide acetate (AT-1001, human zonulin inhibitor) and prolyl-endopeptidases degrading toxic gluten peptides (ALV003, AN-PEP). It is estimated that they will be registered within a few years. They will not become an alternative to the gluten-free diet but rather a supplement to it, which will enable patients to ease the nutritional restrictions...
2015: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/25752709/coeliac-disease-larazotide-acetate-improves-symptoms-of-coeliac-disease-more-than-gluten-free-diet-alone
#3
(no author information available yet)
No abstract text is available yet for this article.
April 2015: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/25683116/larazotide-acetate-for-persistent-symptoms-of-celiac-disease-despite-a-gluten-free-diet-a-randomized-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Daniel A Leffler, Ciaran P Kelly, Peter H R Green, Richard N Fedorak, Anthony DiMarino, Wendy Perrow, Henrik Rasmussen, Chao Wang, Premysl Bercik, Natalie M Bachir, Joseph A Murray
BACKGROUND & AIMS: Celiac disease (CeD) is a prevalent autoimmune condition. Recurrent signs and symptoms are common despite treatment with a gluten-free diet (GFD), yet no approved or proven nondietary treatment is available. METHODS: In this multicenter, randomized, double-blind, placebo-controlled study, we assessed larazotide acetate 0.5, 1, or 2 mg 3 times daily to relieve ongoing symptoms in 342 adults with CeD who had been on a GFD for 12 months or longer and maintained their current GFD during the study...
June 2015: Gastroenterology
https://www.readbyqxmd.com/read/23336684/commentary-larazotide-acetate-an-exciting-new-development-for-coeliac-patients-authors-reply
#5
COMMENT
C P Kelly, P H R Green, J A Murray, A Dimarino, A Colatrella, D A Leffler, T Alexander, R Arsenescu, F Leon, J G Jiang, L A Arterburn, B M Paterson, R N Fedorak
No abstract text is available yet for this article.
February 2013: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/23336683/commentary-larazotide-acetate-an-exciting-new-development-for-coeliac-patients
#6
COMMENT
P D Mooney, D S Sanders
No abstract text is available yet for this article.
February 2013: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/23163616/larazotide-acetate-in-patients-with-coeliac-disease-undergoing-a-gluten-challenge-a-randomised-placebo-controlled-study
#7
RANDOMIZED CONTROLLED TRIAL
C P Kelly, P H R Green, J A Murray, A Dimarino, A Colatrella, D A Leffler, T Alexander, R Arsenescu, F Leon, J G Jiang, L A Arterburn, B M Paterson, R N Fedorak
BACKGROUND: Coeliac disease, an autoimmune disorder triggered by gluten ingestion, is managed by a gluten-free diet (GFD), which is difficult for many patients. Larazotide acetate is a first-in-class oral peptide that prevents tight junction opening, and may reduce gluten uptake and associated sequelae. AIM: To evaluate the efficacy and tolerability of larazotide acetate during gluten challenge. METHODS: This exploratory, double-blind, randomised, placebo-controlled study included 184 patients maintaining a GFD before and during the study...
January 2013: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/22825365/a-randomized-double-blind-study-of-larazotide-acetate-to-prevent-the-activation-of-celiac-disease-during-gluten-challenge
#8
RANDOMIZED CONTROLLED TRIAL
Daniel A Leffler, C P Kelly, H Z Abdallah, A M Colatrella, L A Harris, F Leon, L A Arterburn, B M Paterson, Z H Lan, J A Murray
OBJECTIVES: In patients with celiac disease, enteropathy is caused by the entry of gluten peptides into the lamina propria of the intestine, in which their immunogenicity is potentiated by tissue transglutaminase (tTG) and T-helper type 1-mediated immune responses are triggered. Tight junction disassembly and paracellular permeability are believed to have an important role in the transport of gluten peptides to the lamina propria. Larazotide acetate is a tight-junction regulator peptide that, in vitro, prevents the opening of intestinal epithelial tight junctions...
October 2012: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/22401910/larazotide-acetate-promotes-tight-junction-assembly-in-epithelial-cells
#9
Shobha Gopalakrishnan, Amit Tripathi, Amir P Tamiz, Sefik S Alkan, Niranjan B Pandey
Tight junctions (TJ) control paracellular permeability and apical-basolateral polarity of epithelial cells. Dysregulated permeability is associated with pathological conditions, such as celiac disease and inflammatory bowel disease. TJ formation is dependent on E-cadherin-mediated cell-cell adhesion and actin rearrangement, and is regulated by the Rho family GTPase and aPKC signaling pathways. Larazotide acetate, an 8-mer peptide and TJ modulator, inhibits TJ disassembly and dysfunction caused by endogenous and exogenous stimuli in intestinal epithelial cells...
May 2012: Peptides
https://www.readbyqxmd.com/read/22401908/larazotide-acetate-regulates-epithelial-tight-junctions-in-vitro-and-in-vivo
#10
Shobha Gopalakrishnan, Malarvizhi Durai, Kelly Kitchens, Amir P Tamiz, Robert Somerville, Mark Ginski, Blake M Paterson, Joseph A Murray, Elena F Verdu, Sefik S Alkan, Niranjan B Pandey
Tight junctions (TJs) control paracellular permeability and apical-basolateral polarity of epithelial cells, and can be regulated by exogenous and endogenous stimuli. Dysregulated permeability is associated with pathological conditions, such as celiac disease and inflammatory bowel disease. Herein we studied the mechanism by which larazotide acetate, an 8-mer peptide and TJ regulator, inhibits the cellular changes elicited by gliadin fragments, AT-1002, and cytokines. Previously, we demonstrated that AT-1002, a 6-mer peptide derived from the Vibrio cholerae zonula occludens toxin ZOT, caused several biochemical changes in IEC6 and Caco-2 cells resulting in decreased transepithelial electrical resistance (TEER) and increased TJ permeability...
May 2012: Peptides
https://www.readbyqxmd.com/read/22153524/non-dietary-therapeutic-clinical-trials-in-coeliac-disease
#11
REVIEW
Laura Crespo Pérez, Gemma Castillejo de Villasante, Ana Cano Ruiz, Francisco León
Coeliac disease is a permanent immunological intolerance to gluten proteins in genetically predisposed individuals. The only management is life-long strict adherence to a gluten-free diet. Unfortunately, compliance with gluten-free diet is very difficult in practice due to the widespread presence of gluten in Western diets. For this reason, about 50% of coeliacs following a gluten-free diet continue to suffer from symptoms and present with autoantibodies and/or villous atrophy while on a gluten-free diet. It is therefore important to explore new therapies to improve the management of coeliac disease...
January 2012: European Journal of Internal Medicine
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