keyword
https://read.qxmd.com/read/38344024/oral-malignant-acanthosis-nigricans-an-early-diagnostic-sign-for-ovarian-carcinoma-a-case-report
#1
Yang Liu, Xiaoli Wu, Siting Chen, Wenxia Meng
Acanthosis nigricans (AN) is a dermatological condition characterised by the symmetrical development of velvety, hyperpigmented plaques predominantly in intertriginous areas such as the axillae, neck, inframammary regions, and groin. The malignant variant of AN is frequently associated with internal malignancies, particularly gastric adenocarcinoma, accounting for 55-61% of cases. Patients exhibiting characteristic skin lesions are commonly initially evaluated in dermatology departments. This case report details a rare instance of a patient diagnosed with malignant acanthosis nigricans, presenting with only a mild form of florid oral papillomatosis concomitant with ovarian carcinoma...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38173884/bullous-pemphigoid-malignant-acanthosis-nigricans-and-erysipeloid-carcinoma-in-a-woman-with-gastric-adenocarcinoma
#2
Saman Al-Zahawi, Yasaman Sadeghi, Vahidesadat Azhari, Hamidreza Mahmoudi, Maryam Daneshpazhooh
KEY CLINICAL MESSAGE: Bullous pemphigoid did not follow the course of Gastric Carcinoma relapse and remisson, unlike the malignant acanthosis nigricans which was in alignment with the paraneoplastic effect of the Gastric Carcinoma. ABSTRACT: Acanthosis nigricans (AN) is a dermatosis characterized by the presence of hyperpigmented, velvety cutaneous thickening in the flexural areas, posterior neck, and occasionally the extensor surfaces of hand, face, and oral mucosa...
January 2024: Clinical Case Reports
https://read.qxmd.com/read/37900822/acanthosis-nigricans-in-a-patient-with-urothelial-carcinoma-treated-with-pd-l1-inhibitor-avelumab-and-secondary-adrenal-insufficiency
#3
Fei Ya Lai, Emmet Jordan
Acanthosis nigricans (AN) describes hyperkeratotic and hyperpigmented skin changes and its pathophysiology is linked to the activation of epidermal growth factor receptors. Current literature shows that AN is most commonly diagnosed at the time of the underlying pathology, which may occur under benign or malignant conditions. This case presentation demonstrates the occurrence of AN in a patient following the diagnosis of urothelial carcinoma and ongoing treatment with PD-L1 inhibitor immunotherapy. Subsequent investigations ruled out a secondary malignancy or disease progression; however, metabolic screening identified secondary glucocorticoid induced adrenal insufficiency...
2023: Case Reports in Oncology
https://read.qxmd.com/read/37815015/early-onset-diabetes-mellitus-as-a-presenting-feature-of-werner-s-syndrome-in-an-indian-family
#4
JOURNAL ARTICLE
Fieke W Hoff, Chao Xing, Vinaya Simha, Anil K Agarwal, Xunzhi Zhang, Leena Lekkala, Madhumati S Vaishnav, Frank Vuitch, Abhimanyu Garg
BACKGROUND: Diabetes mellitus (DM) in children and adolescents is typically caused by type 1 DM, followed by type 2 DM and maturity-onset diabetes of the young (MODY). We report an unusual Asian Indian family in which three members presented with DM at ages 15, 20, and 30, but not fitting the typical clinical picture of type 1 DM, type 2 DM, or MODY. The primary objective was to elucidate the molecular genetic basis of DM in this family. METHODS: The proband, a 22-year-old man, had short stature, gray hair, osteoporosis, and markedly reduced subcutaneous fat on the body, especially on the extremities along with acanthosis nigricans, and developed myxoid malignant peripheral nerve sheath tumor...
October 10, 2023: Molecular Genetics & Genomic Medicine
https://read.qxmd.com/read/37655107/case-report-paraneoplastic-psoriasis-in-thymic-carcinoma
#5
Lucas Mix, Manuel Knoll, Max-Felix Häring, Wolfgang Andreas Bethge, Jan C Schröder, Stephan Forchhammer, Patrick Krumm, Christian M Schürch, Martin Schaller, Claudia Lengerke
Thymic carcinomas are exceedingly rare and very aggressive malignancies of the anterior mediastinum. While thymomas exhibit a high association with paraneoplastic syndromes, these phenomena are a rarity in thymic carcinomas. In general, acanthotic syndromes such as acroceratosis neoplastica and acanthosis nigricans maligna are commonly observed as paraneoplastic phenomena in patients with carcinomas. In contrast, psoriasis vulgaris, another acanthotic disease, rarely occurs as a paraneoplasia. We report the case of a 36-year-old patient with progressive thymic carcinoma (undifferentiated carcinoma, T3N2M1a) and paraneoplastic psoriasis occurring ten months before the initial diagnosis of the carcinoma...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37489275/metastatic-adenocarcinoma-of-the-stomach-presenting-as-malignant-acanthosis-nigricans-and-tripe-palms-a-case-report
#6
JOURNAL ARTICLE
C P M Lam, M W M Chan
No abstract text is available yet for this article.
August 2023: Hong Kong Medical Journal
https://read.qxmd.com/read/37324176/correlated-improvement-of-mucosal-malignant-acanthosis-nigricans-and-metastatic-urothelial-carcinoma-with-oncologic-therapy
#7
Rachel Fayne, Julie E Mervak
No abstract text is available yet for this article.
July 2023: JAAD Case Reports
https://read.qxmd.com/read/37033504/acanthosis-nigricans-manifesting-as-a-paraneoplastic-syndrome-associated-with-cholangiocarcinoma
#8
Mariana Costa, Ana Valente, Andreia Freire Coelho, Sara Meireles, Miguel Barbosa
We present the case of a 64-year-old woman with type 2 diabetes who was diagnosed with early-stage intrahepatic cholangiocarcinoma and underwent partial hepatectomy followed by adjuvant chemotherapy. The patient simultaneously developed skin lesions compatible with acanthosis nigricans (AN). Thirty-seven months after completing chemotherapy, the patient had a recurrence of extensive skin and mucosal lesions compatible with AN. A thoracic-abdominal-pelvic (TAP) CT showed a relapse with hepatic hilar adenopathy...
March 2023: Curēus
https://read.qxmd.com/read/36920759/malignant-acanthosis-nigricans
#9
JOURNAL ARTICLE
Huei-Jing Wang, S Chu-Sung Hu
New England Journal of Medicine, Volume 388, Issue 11, Page 1031-1031, March 2023.
March 16, 2023: New England Journal of Medicine
https://read.qxmd.com/read/36283741/malignant-acanthosis-nigricans-a-cutaneous-marker-of-hepatocellular-carcinoma
#10
JOURNAL ARTICLE
Konsam Nirupama Devi, Gurumayum Chitralekha Devi, Purna Sethy, Neirita Hazarika
No abstract text is available yet for this article.
October 25, 2022: BMJ Case Reports
https://read.qxmd.com/read/35891736/non-infectious-dermatological-manifestations-among-patients-with-diabetes-mellitus-in-basrah-iraq
#11
JOURNAL ARTICLE
A Sabah Abdulridha Budair, K Ismail Al Hamdi, A Ali Mansour
Diabetes mellitus (DM) is a clinical illness usually linked to a wide range of skin manifestations; however, skin, as the greatest organ in the body, has received little attention. As a result, this study aimed to detect the prevalence and pattern of non-infectious skin disorders among patients with diabetes. This study was carried out at the Faiha Specialized Diabetes, Endocrine, and Metabolism Center, Basrah Province, Iraq, from September 2020 to September 2021. The data were collected from 347 patients with Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM)...
February 2022: Archives of Razi Institute
https://read.qxmd.com/read/35642678/acanthosis-nigricans-in-a-patient-with-metastatic-insulinoma-post-peptide-receptor-radionuclide-therapy
#12
JOURNAL ARTICLE
Jenny S W Yun, Chris McCormack, Michelle Goh, Cherie Chiang
Summary: Acanthosis nigricans (AN) is a common dermatosis associated with hyperinsulinemia and insulin resistance. However, AN has been rarely reported in patients with insulinoma, a state of persistent hyperinsulinemia. We present a case of metastatic insulinoma, in whom AN manifested after the first cycle of peptide receptor radionuclide therapy (PRRT). A 40-year-old man was diagnosed with metastatic insulinoma after 5 months of symptomatic hypoglycemia. Within 1 month post PRRT, the patient became euglycemic but developed a pigmented, pruritic rash which was confirmed on biopsy as AN...
June 1, 2022: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/35369048/the-link-between-obesity-and-the-skin
#13
REVIEW
Razvigor Darlenski, Vesselina Mihaylova, Teodora Handjieva-Darlenska
Obesity as a multi-organ disease that affects the entire human organism. Notably, the skin is no exclusion from this postulate. Skin changes in obese patients have been widely studied with regards to mechanical friction, skin infections, and skin hypertrophic conditions, such as acanthosis nigricans and, most commonly, fibromas (skin tags). Almost 60-70% of obese patients present with a variety of skin changes. Herein, we discuss our own experience and review the complex skin changes in obesity. The role of metabolic syndrome and obesity are responsible for the epidemiological prevalence and are involved in the pathogenesis of chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, and skin malignancies...
2022: Frontiers in Nutrition
https://read.qxmd.com/read/35136792/prevalence-of-acanthosis-nigricans-and-its-association-with-physical-activity-in-adolescents-school-based-analytical-cross-sectional-study-from-kochi-kerala
#14
JOURNAL ARTICLE
Remya Sudevan, S Vijay Kumar, Clint Sunny, Nanditha Sunand, Anu Vasudevan, Sonu K S, Apsy P V
INTRODUCTION: Acanthosis nigricans (AN) is a brown to black, poorly defined velvety hyperpigmentation of the skin. It is a predisposition factor for Type 2 diabetes, malignancies and various endocrinopathies. The available data regarding AN from Kerala is limited. Our study aims to estimate the prevalence of AN and to examine its association with physical activity among the adolescents of age 13-14 years. METHODOLOGY: This analytical cross-sectional study was conducted in two grades of a school in Ernakulam district between June and December 2018 among 400 adolescents of age 13-14 years...
November 2021: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/34990347/a-case-of-nevoid-acanthosis-nigricans-successfully-treated-with-topical-ketoconazole-plus-urea
#15
JOURNAL ARTICLE
Ayaki Matsumoto, Kozo Nakai, Daisuke Tsuruta, Koji Sugawara
Dear Editor, Nevoid acanthosis nigricans (AN) is a rare form of benign AN that can be mostly found as a solitary lesion distributed along Blaschko's lines (1). It is not associated with any known syndrome, endocrinopathy, drugs, or internal malignancy. Treatments include retinoid, calcipotriol, and laser treatments (2). Herein we report a case of nevoid AN successfully treated with topical ketoconazole plus urea. A 15-year-old woman presented with a 3-year history of asymptomatic plaques on her abdomen that were increasing in size...
December 2021: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/34934743/malignant-acanthosis-nigricans-as-a-paraneoplastic-precursor-of-metastatic-cholangiocarcinoma
#16
JOURNAL ARTICLE
Jonathan Stevens, Luis Mena-Vergara, Mariana Silva-Astorga, Cecilia Jeraldo
No abstract text is available yet for this article.
November 2021: Indian Dermatology Online Journal
https://read.qxmd.com/read/34760088/diagnosis-of-an-occult-gastric-adenocarcinoma-by-oral-manifestations-acanthosis-nigricans-a-case-report
#17
Pegah Mosannen Mozafari, Roham Salek, Ava Taghizadeh, Mohammad Javad Yazdanpanah, Hooman Mosannen Mozaffari, Elham Esmaeili
Background: Acanthosis nigricans (AN) is a condition with an important characteristics of symmetrical areas of thickened skin with grayish brown hyperpigmentation. The mucosa may show a papillomatous surface, with or without hyperpigmentation. Lips and sites at risk of trauma may be affected and palmoplantar keratosis might also be present. In some rare cases, acanthosis nigricans presents as a sign of internal neoplasia, mostly a gastrointestinal cancer, and is called malignant acanthosis nigricans (MAN)...
2021: Caspian Journal of Internal Medicine
https://read.qxmd.com/read/34750849/malignant-acanthosis-nigricans-and-diseases-with-extensive-oral-papillary-hyperplasia
#18
REVIEW
Y Liu, X Xu, Y Yang, H Hu, X Jiang, X Xiong, W Meng
Oral papillary lesions represent a variety of developmental and neoplastic conditions. Early diagnoses of different papillary lesions are challenging for oral medicine specialists. Malignant acanthosis nigricans (MAN) is a rare cutaneous disorder and a potential marker of underlying hidden tumours. It is characterized by papillary lesions that always involve the oral mucosa. In oral medicine specialities, MAN is not well understood. When the early signs of MAN are extensive oral lesions and slight cutaneous pigmentation without obvious florid cutaneous papillomatosis, the diagnosis can be incorrect or delayed...
April 2022: Clinical and Experimental Dermatology
https://read.qxmd.com/read/34303397/paraneoplastic-dermatoses-in-breast-cancer-malignant-acanthosis-nigricans-with-tripe-palm
#19
JOURNAL ARTICLE
Caroline Omram Ahmed, Maria Kátia Gomes, Thales Pereira de Azevedo, Tullia Cuzzi, Marcia Ramos-E-Silva
Our patient was a 43-year-old, single black woman, born and living in Paracambi, State of Rio de Janeiro, who worked as a surgical instrumentalist. She was sent to our sector of dermatology due to hypochromia and diffuse skin roughness that had first appeared 8 years previously. She had been diagnosed 6 months before admission with ductal infiltrating metastatic carcinoma in the right breast, with therapeutic failure of chemotherapy and radiotherapy. Her menarche had occurred at age 13 years, she reported normal menstrual cycles from there on, and she had never been pregnant...
2021: Skinmed
https://read.qxmd.com/read/33745631/cutaneous-paraneoplastic-syndromes-with-nail-involvement
#20
REVIEW
Athina Fonia, Robert Baran
The cutaneous paraneoplastic syndromes are rare and intrinsically devoid of any neoplastic nature. The manifestations on the skin and the nails are due to various mechanisms caused by the tumor, either due to production of bioactive substances or in response to it. These disorders evolve in parallel to the malignancy, in that, they regress when the tumor is removed and reappear in the case of tumor recurrence. The aim of this article is to aid with the early recognition of the signs, leading to the early detection of cancer and therefore to better clinical outcomes for the patients...
April 2021: Dermatologic Clinics
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