Qiong Fu, Jin-Juan Zhang, Qin-Feng Zhu, Ling-Ling Yu, Fang Wang, Jing Li, Xun He, Jun-Li Ao, Guo-Bo Xu, Mao-Chen Wei, Xing-Jiang Liao, Shang-Gao Liao
Hyperuricemia (HUA) is caused by increased synthesis and/or insufficient excretion of uric acid (UA). Long-lasting HUA may lead to a number of diseases including gout and kidney injury. Harpagoside (Harp) is a bioactive compound with potent anti-inflammatory activity from the roots of Scrophularia ningpoensis. Nevertheless, its potential effect on HUA was not reported. The anti-HUA and nephroprotective effects of Harp on HUA mice were assessed by biochemical and histological analysis. The proteins responsible for UA production and transportation were investigated to figure out its anti-HUA mechanism, while proteins related to NF-κB/NLRP3 pathway were evaluated to reveal its nephroprotective mechanism...
April 30, 2024: Biochemical and Biophysical Research Communications