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https://www.readbyqxmd.com/read/29451184/the-long-term-outcomes-of-cirrhotic-patients-with-pleural-effusion
#1
Tsung-Hsing Hung, Chih-Wei Tseng, Chih-Chun Tsai, Chen-Chi Tsai, Kuo-Chih Tseng, Yu-Hsi Hsieh
Background/Aim: A pleural effusion is an abnormal collection of fluid in the pleural space and may cause related morbidity or mortality in cirrhotic patients. Currently, there are insufficient data to support the long-term prognosis for cirrhotic patients with pleural effusion. In this study, we investigated the short- and long-term effects of pleural effusion on mortality in cirrhotic patients and evaluated the benefit of liver transplantation in these patients. Patients and Methods: The National Health Insurance Database, derived from the Taiwan National Health Insurance Program, was used to identify 3,487 cirrhotic patients with pleural effusion requiring drainage between January 1, 2007 and December 31, 2010...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29450683/common-adverse-effects-of-novel-therapies-for-multiple-myeloma-mm-and-their-management-strategies
#2
REVIEW
Kristen B McCullough, Miriam A Hobbs, Jithma P Abeykoon, Prashant Kapoor
PURPOSE OF REVIEW: The purpose of this review was to evaluate management strategies for common adverse effects of novel therapies in multiple myeloma (MM), including immunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, and a histone deacetylase inhibitor. RECENT FINDINGS: There are several adverse effects that occur across multiple classes of antimyeloma drugs, including rash, peripheral neuropathy, infusion reactions, and cardiotoxicity, but most can be managed without complete discontinuation of the agent or abandonment of the class...
February 15, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29447255/hydroxyethyl-starch-for-volume-expansion-after-subarachnoid-haemorrhage-and-renal-function-results-of-a-retrospective-analysis
#3
Sven Bercker, Tanja Winkelmann, Thilo Busch, Sven Laudi, Dirk Lindner, Jürgen Meixensberger
BACKGROUND: Hydroxyethyl starch (HES) was part of "triple-H" therapy for prophylaxis and therapy of vasospasm in patients with subarachnoid haemorrhage (SAH). The European Medicines Agency restricted the use of HES in 2013 due to an increase of renal failure in critically ill patients receiving HES compared to crystalloid fluids. The occurrence of renal insufficiency in patients with SAH due to HES is still uncertain. The purpose of our study was to evaluate whether there was an association with renal impairment in patients receiving HES after subarachnoid haemorrhage...
2018: PloS One
https://www.readbyqxmd.com/read/29443737/effect-of-tenofovir-on-renal-function-in-patients-with-chronic-hepatitis-b
#4
Woo Jin Jung, Jae Young Jang, Won Young Park, Soung Won Jeong, Hee Jeong Lee, Sang Joon Park, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Suyeon Park, Baigal Baymbajav
Tenofovir disoproxil fumarate (TDF) is widely used to treat patients with hepatitis B virus (HBV) infection. We investigated the effect of TDF on renal insufficiency in patients with chronic hepatitis B (CHB).A consecutive cohort analysis was applied to CHB patients taking prescribed TDF from January 2012 to May 2016 at Soonchunhyang University Seoul Hospital. Alterations over time in corrected calcium, phosphate, creatinine, and estimated glomerular filtration rate (eGFR) were analyzed using the generalized estimating equation method...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29435748/surgery-for-benign-esophageal-disorders-in-the-us-risk-factors-for-complications-and-trends-of-morbidity
#5
Francisco Schlottmann, Paula D Strassle, Marco G Patti
BACKGROUND: Gastroesophageal reflux disease (GERD), paraesophageal hernia (PEH), and achalasia are the most frequent benign esophageal disorders that may need surgical treatment. We aimed to identify risk factors for postoperative complications and to characterize trends of morbidity for surgery for benign esophageal disorders in a national cohort. METHODS: A retrospective population-based analysis was performed using the National Inpatient Sample for the period 2000-2013...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29435320/outcome-and-natural-course-of-renal-dysfunction-in-liver-transplant-recipients-with-severely-impaired-kidney-function-prior-to-transplantation
#6
T Horvatits, S Pischke, V M Proske, L Fischer, S Scheidat, F Thaiss, V Fuhrmann, A W Lohse, B Nashan, M Sterneck
Background: Since introduction of the MELD score in the liver allograft allocation system, renal insufficiency has emerged as an increasing problem. Here we evaluated the course of kidney function in patients with advanced renal insufficiency prior to liver transplantation (LT). Methods: A total of 254 patients undergoing LT at the University Medical Centre Hamburg-Eppendorf (2011-2015) were screened for renal impairment (GFR < 30 ml/min) prior to LT in this observational study...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29431364/chronic-kidney-disease-detection-and-evaluation
#7
David Y Gaitonde, David L Cook, Ian M Rivera
Chronic kidney disease affects 47 million people in the United States and is associated with significant health care costs, morbidity, and mortality. Because this disease can silently progress to advanced stages, early detection is critical for initiating timely interventions. Multiple guidelines recommend at least annual screening with serum creatinine, urine albumin/creatinine ratio, and urinalysis for patients with risk factors, particularly diabetes mellitus, hypertension, and a history of cardiovascular disease...
December 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29427619/the-association-of-aortic-valve-pathology-with-renal-resistive-index-as-a-kidney-injury-biomarker
#8
Benjamin Y Andrew, Anne D Cherry, Jennifer N Hauck, Alina Nicoara, Cory D Maxwell, Ryan M Konoske, Annemarie Thompson, Lakshmi D Kartha, Madhav Swaminathan, Mark Stafford-Smith
BACKGROUND: Acute kidney injury (AKI) is a common serious complication following cardiac surgery. Doppler-determined renal resistive index (RRI) is a promising early AKI biomarker in this population. However, the relationship between aortic valve pathology (insufficiency and/or stenosis) and RRI is unknown. This study aimed to investigate RRI variability related to aortic valve pathology. METHODS: In a retrospective review of cardiac surgery patients, RRI and aortic valve pathology were assessed prior to cardiopulmonary bypass using transesophageal echocardiography...
February 7, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29422388/acetazolamide-based-18f-pet-tracer-in-vivo-validation-of-carbonic-anhydrase-ix-as-a-sole-target-for-imaging-of-ca-ix-expressing-hypoxic-solid-tumors
#9
Kunal N More, Jun Young Lee, Dong-Yeon Kim, Nam-Chul Cho, Ayoung Pyo, Misun Yun, Hyeon Sik Kim, Hangun Kim, Kwangseok Ko, Jeong-Hoon Park, Dong-Jo Chang
Carbonic anhydrase IX is overexpressed in many solid tumors including hypoxic tumors and is a potential target for cancer therapy and diagnosis. Reported imaging agents targeting CA-IX are successful mostly in clear cell renal carcinoma as SKRC-52 and no candidate was approved yet in clinical trials for imaging of CA-IX. To validate CA-IX as a valid target for imaging of hypoxic tumor, we designed and synthesized novel [18F]-PET tracer (1) based on acetazolamide which is one of the well-known CA-IX inhibitors and performed imaging study in CA-IX expressing hypoxic tumor model as 4T1 and HT-29 in vivo models other than SKRC-52...
February 1, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29422319/atypical-cowpox-virus-infection-in-a-series-of-cats
#10
N Jungwirth, C Puff, K Köster, R Mischke, H Meyer, A Stark, B Thoma, G Zöller, F Seehusen, M Hewicker-Trautwein, A Beineke, W Baumgärtner, P Wohlsein
Within 4 weeks, five cats with skin lesions affecting the hindlimbs and mainly consisting of oedema, hyperaemia and plaque-like alterations were presented to the same veterinary clinic. The cats were suffering from lameness, trauma, renal insufficiency or complicated tail amputation. Although the lesions seemed unusual for a poxvirus infection, microscopical examination of biopsy samples or specimens taken during necropsy examination revealed ballooning degeneration of keratinocytes with eosinophilic, cytoplasmic inclusion bodies indicative of an orthopoxvirus infection...
January 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29412318/predicting-survival-function-and-identifying-associated-factors-in-patients-with-renal-insufficiency-in-the-metropolitan-area-of-maring%C3%A3-paran%C3%A3-state-brazil
#11
Thiago G Ramires, Luiz R Nakamura, Ana J Righetto, Edwin M M Ortega, Gauss M Cordeiro
Renal insufficiency is a serious medical and public health problem worldwide. Recently, although many surveys have been developed to identify factors related to the lifetime of patients with renal insufficiency, controversial results from several studies suggest that researches should be conducted by region. Thus, in this study we aim to predict and identify factors associated with the lifetime of patients with chronic renal failure (CRF) in the metropolitan area of Maringá, Paraná State, Brazil, based on the generalized additive models for location, scale and shape (GAMLSS) framework...
February 5, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29411162/ensuring-safe-drug-administration-to-pediatric-patients-with-renal-dysfunction-a-multicenter-study
#12
Ryoko Harada, Kenji Ishikura, Shunsuke Shinozuka, Naoaki Mikami, Riku Hamada, Hiroshi Hataya, Yoshihiko Morikawa, Tae Omori, Hirotaka Takahashi, Yuko Hamasaki, Tetsuji Kaneko, Kazumoto Iijima, Masataka Honda
BACKGROUND: In pediatric patients, due to variations in baseline serum creatinine (Cr) reference values, renal dysfunctions sometimes go unnoticed. In addition, renally excreted drugs need dose adjustment while nephrotoxic drugs should be avoided altogether in patients with impaired renal function. However, most physicians are apparently unaware of these facts and may administer these drugs to vulnerable patients. METHODS: We administered a questionnaire to all physicians and pharmacists specializing in pediatric medical care at six Tokyo metropolitan government-run hospitals in Japan...
February 6, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29408429/complications-of-recognized-and-unrecognized-iatrogenic-ureteral-injury-at-time-of-hysterectomy-a-population-based-analysis
#13
Robert H Blackwell, Eric J Kirshenbaum, Arpeet S Shah, Paul C Kuo, Gopal N Gupta, Thomas M T Turk
PURPOSE: Ureteral injury represents an uncommon but potentially morbid complication surgical complication. This study sought to characterize the complications of iatrogenic ureteral injury and assess the effect of recognized vs delayed recognition on patient outcomes. MATERIALS AND METHODS: Hysterectomy patients were identified in the Healthcare Cost and Utilization Project State Inpatient Database for California, years 2007-2011. Ureteral injuries were identified and categorized as recognized (diagnosed/repaired the day of hysterectomy) and unrecognized (diagnosed/repaired postoperatively)...
February 2, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29404986/predictors-of-short-term-readmission-after-pancreaticoduodenectomy
#14
Rajesh Ramanathan, Travis Mason, Luke G Wolfe, Brian J Kaplan
BACKGROUND: Readmissions are a common complication after pancreaticoduodenectomy and are increasingly being used as a performance metric affecting quality assessment, public reporting, and reimbursement. This study aims to identify general and pancreatectomy-specific factors contributing to 30-day readmission after pancreaticoduodenectomy, and determine the additive value of incorporating pancreatectomy-specific factors into a large national dataset. METHODS: Prospective American College of Surgeons-National Surgical Quality Improvement Project (ACS-NSQIP) data were retrospectively analyzed for patients who underwent pancreaticoduodenectomy (PD) between 2011 and 2015...
February 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29399206/joint-modeling-of-repeated-measures-and-competing-failure-events-in-a-study-of-chronic-kidney-disease
#15
Wei Yang, Dawei Xie, Qiang Pan, Harold I Feldman, Wensheng Guo
We are motivated by the Chronic Renal Insufficiency Cohort (CRIC) study to identify risk factors for renal progression in patients with chronic kidney diseases. The CRIC study collects two types of renal outcomes: glomerular filtration rate (GFR) estimated annually and end stage renal disease (ESRD). A related outcome of interest is death which is a competing event for ESRD. A joint modeling approach is proposed to model a longitudinal outcome and two competing survival outcomes. We assume multivariate normality on the joint distribution of the longitudinal and survival outcomes...
December 2017: Statistics in Biosciences
https://www.readbyqxmd.com/read/29399101/vaccarin-alleviates-hypertension-and-nephropathy-in-renovascular-hypertensive-rats
#16
Weiwei Cai, Zhenpeng Zhang, Yiqi Huang, Haijian Sun, Liying Qiu
The kidney is an important organ in the regulation of blood pressure, and it is also one of the primary target organs of hypertension. Kidney damage in response to hypertension eventually leads to renal insufficiency. The authors previously demonstrated that vaccarin exhibits a protective role in endothelial injury. However, the effects of vaccarin on the two-kidney, one clip (2K1C) renovascular hypertension model and subsequent kidney injury have yet to be fully elucidated. The present study was designed to investigate the roles and mechanisms of vaccarin in attenuating hypertension and whether vaccarin had beneficial effects on kidney injury...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29399041/insights-into-the-management-of-gastric-antral-vascular-ectasia-watermelon-stomach
#17
REVIEW
Wen-Hung Hsu, Yao-Kuang Wang, Meng-Shu Hsieh, Fu-Chen Kuo, Meng-Chieh Wu, Hsiang-Yao Shih, I-Chen Wu, Fang-Jung Yu, Huang-Ming Hu, Yu-Chung Su, Deng-Chyang Wu
Gastric antral vascular ectasia (GAVE) is an uncommon but important cause of chronic gastrointestinal bleeding. It is often associated with systemic diseases such as autoimmune diseases, liver cirrhosis, chronic renal insufficiency and cardiovascular disease. The etiology of GAVE has not been fully explored and remains controversial. Diagnosis is mainly based on endoscopic presentation with flat or raised erythematous stripes radiating from the pylorus to the antrum and resembles a watermelon. Clinical presentation may range from iron-deficiency anemia secondary to occult blood loss, melena to hematemesis...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29398456/comparison-of-partial-versus-radical-nephrectomy-effect-on-other-cause-mortality-cancer-specific-mortality-and-30-day-mortality-in-patients-older-than-75-years
#18
Michele Marchioni, Felix Preisser, Marco Bandini, Sebastiano Nazzani, Zhe Tian, Anil Kapoor, Luca Cindolo, Firas Abdollah, Derya Tilki, Alberto Briganti, Francesco Montorsi, Shahrokh F Shariat, Luigi Schips, Pierre I Karakiewicz
BACKGROUND: Historically, partial nephrectomy (PN) showed no benefit on other-cause mortality (OCM) in elderly patients with small renal masses. OBJECTIVE: To test the effect of PN versus radical nephrectomy (RN) on OCM, cancer-specific mortality (CSM), as well as 30-d mortality in patients with nonmetastatic T1a renal cell carcinoma (RCC), aged ≥75 yr old. DESIGN, SETTING, AND PARTICIPANTS: Within the Surveillance, Epidemiology and End Results registry (2004-2014), we identified surgically treated patients with nonmetastatic pT1a RCC aged ≥75 yr...
February 2, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29398426/the-influence-of-fluid-management-on-outcomes-in-preeclampsia-a-systematic-review-and-meta-analysis
#19
T Pretorius, G van Rensburg, R A Dyer, B M Biccard
BACKGROUND: The optimal fluid management strategy to ensure best outcomes in preeclamptic patients remains a controversial issue, with little evidence to support any one approach. OBJECTIVE: The aim of this systematic review was to investigate the effect of various fluid management strategies on clinical outcomes, haemodynamic indices and biochemical markers in preeclamptic women and their babies. Primary outcome measures were the occurrence of pulmonary oedema and/or the development of renal impairment...
December 20, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29395726/renal-scintigraphy-for-post-transplant-monitoring-after-kidney-transplantation
#20
REVIEW
S Benjamens, S P Berger, A W J M Glaudemans, J S F Sanders, R A Pol, R H J A Slart
BACKGROUND: Clinicians use several diagnostic modalities to recognize post-transplant complications, such as acute tubular necrosis, acute rejection, urologic and vascular complications. Currently, there is no consensus about the best procedural approach to evaluate post-transplant renal dysfunction. Renal needle-biopsy is often required, however, this is invasive and may lead to sample errors and complications, and most clinicians prefer using one of the noninvasive diagnostic modalities...
December 29, 2017: Transplantation Reviews
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