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https://www.readbyqxmd.com/read/29243107/impact-of-geriatric-assessment-for-the-therapeutic-decision-making-of-breast-cancer-results-of-a-french-survey-afsos-and-sofog-collaborative-work
#1
Claire Falandry, Ivan Krakowski, Hervé Curé, Elisabeth Carola, Pierre Soubeyran, Olivier Guérin, Hélène Gaudin, Gilles Freyer
BACKGROUND: Cancer management in the elderly is often considered as suboptimal, highly variable, and rarely evidence-based. Data are needed to understand decision-making processes in this population. MATERIALS AND METHODS: A survey was performed in France to describe decision-making in gynaecologic patients over 70. It followed a three-step method: (1) 101 representative physicians questioned about treatment decision criteria; (2) simplified individual data were collected; (3) as well as detailed data patients receiving chemotherapy...
December 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29240798/the-cost-of-comorbidities-in-treatment-for-hiv-aids-in-california
#2
David S Zingmond, Kodi B Arfer, Jennifer L Gildner, Arleen A Leibowitz
BACKGROUND: Antiretroviral therapy has increased longevity for people living with HIV (PLWH). As a result, PLWH increasingly experience the common diseases of aging and the resources needed to manage these comorbidities are increasing. This paper characterizes the number and types of comorbidities diagnosed among PLWH covered by Medicare and examines how non-HIV comorbidities relate to outpatient, inpatient, and pharmaceutical expenditures. METHODS: The study examined Medicare expenditures for 9767 HIV-positive Californians enrolled in Medicare in 2010 (7208 persons dually covered by Medicare and Medicaid and 2559 with Medicare only)...
2017: PloS One
https://www.readbyqxmd.com/read/29238578/bone-eating-kidney-disease
#3
Abhilash Koratala, Muhannad Leghrouz, Amir Kazory
In the current era of early detection of chronic kidney disease and efficient therapeutic options for management of its complications, skeletal manifestations of renal hyperparathyroidism are increasingly rare. A 31-year-old female patient presented for evaluation of severe pain in the left forearm, right hand, right knee, right hip, and lower back following a fall sustained 3 days prior to presentation. She had a history of end-stage renal disease and received maintenance hemodialysis. Review of the medical records revealed that she had poor compliance with her diet, medications, and dialysis treatments...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29235430/prevalence-and-risk-factors-for-delirium-diagnosis-in-patients-followed-in-general-practices-in-germany
#4
Jens Bohlken, Karel Kostev
BACKGROUND: The aim of this study is to identify the prevalence and risk factors of documented delirium in general practices in Germany. METHODS: The present study includes 2,194 patients over the age of 65 years with delirium and 2,194 controls without delirium from a sample of 6,180,042 patients from 1,262 general practices. Multivariate logistic regression models were fitted with delirium as a dependent variable and other disorders and drugs as potential predictors...
December 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29233453/cytological-diagnosis-of-a-rare-case-of-cutaneous-metastasis-from-transitional-cell-carcinoma-renal-pelvis
#5
Pragya Singh, Sachin Kolte, Gunjesh Kumar Singh
Transitional cell carcinoma (TCC) arising from renal pelvis rarely gives rise to cutaneous metastasis. Due to the insufficient literature, the exact incidence is not known till date. Moreover, the diagnosis is confirmed on histopathological examination with the aid of immunohistochemistry wherever needed. We are presenting a case of a 70-year-old female with metastatic TCC from the renal pelvis to the abdominal skin, which was diagnosed on cytology alone along with the cell block preparation. We also highlight the important cytomorphological and immunohistochemical features noted, which need to be known to avoid any diagnostic delay...
December 7, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29231753/rates-of-insufficiency-and-deficiency-of-vitamin-d-levels-in-elite-professional-male-and-female-skiers-a-chronobiologic-approach
#6
Jacopo Antonino Vitale, Giovanni Lombardi, Luca Cavaleri, Rosa Graziani, Herbert Schoenhuber, Antonio La Torre, Giuseppe Banfi
Vitamin D is essential for the maintenance and promotion of musculoskeletal health, for the functioning of the immune, cardiovascular and reproductive systems, and its main action is to keep calcium and phosphate plasmatic physiological concentrations at intestinal, renal and bony level. Vitamin D affects several parameters related to physical performance too and a particularly high percentage of vitamin D insufficiency and deficiency in professional athletes has been observed. Several variables are able to impair the synthesis of 25(OH)D in athletes, specifically both genetic and environmental factors, but the most probable explanation for the deficient/insufficient vitamin D levels is the insufficient ultraviolet B light (UVB) exposure during winter...
December 12, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29230963/unravelling-current-sexual-care-in-chronic-kidney-disease-perspective-of-social-workers
#7
Gaby F van Ek, Dirry Keurhorst, Esmée M Krouwel, Melianthe P J Nicolai, Marjolein E M Den Ouden, Henk W Elzevier, Hein Putter, Rob C M Pelger, Brenda L Den Oudsten
BACKGROUND: Fifty to eighty percent of patients suffering from chronic kidney disease (CKD) experience a form of sexual dysfunction (SD), even after renal transplantation. Despite this, inquiring about SD is often not included in the daily practice of renal care providers. OBJECTIVES: This paper explores the perspectives of renal social workers regarding sexual care for patients and evaluates their practice, attitude towards responsibility and knowledge of SD. DESIGN: A cross-sectional study was conducted using a 41-item online survey...
December 12, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/29228529/efficacy-of-bronchial-washing-and-brushing-cytology-in-the-diagnosis-of-non-neoplastic-lung-diseases
#8
Rahil Giti, Massood Hosseinzadeh
Flexible fiberoptic bronchoscopy is often the initial technique for diagnosis of lung and bronchial tumors. Many studies have shown the high accuracy rate of bronchial washing and brushing cytology in the evaluation of neoplastic and non-neoplastic bronchopulmonary lesions. The aim of this study is to emphasize the value of the bronchial cytologic findings for diagnosis of non-neoplastic bronchopulmonary lesions. In a cross-sectional study, we retrieved all cases with bronchial washing and brushing cytology from 21 Mach 2014 to 21 December 2015...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29225801/histologic-regression-of-fibrillary-glomerulonephritis-the-first-report-of-biopsy-proven-spontaneous-resolution-of-disease
#9
Miroslav Sekulic, Samih H Nasr, Joseph P Grande, Lynn D Cornell
Fibrillary glomerulonephritis (FGN) is a rare immune complex type glomerulonephritis characterized by glomerular deposition of randomly oriented fibrils measuring 10-30 nm in thickness, and typically presents with proteinuria with or without renal insufficiency and hematuria. We present a case in which a patient initially presented at age 41 years with nephrotic-range proteinuria and hypertension; a kidney biopsy showed FGN. The patient was treated with angiotensin receptor blockage only, without immunosuppression as per patient preference, and the level of protein in the urine improved...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29223429/predicting-risk-of-cardiac-events-among-st-segment-elevation-myocardial-infarction-patients-with-conservatively-managed-non-infarct-related-artery-coronary-artery-disease-an-analysis-of-the-duke-databank-for-cardiovascular-disease
#10
RANDOMIZED CONTROLLED TRIAL
Sameer A Hirji, Susanna R Stevens, Linda K Shaw, Erin C Campbell, Christopher B Granger, Manesh R Patel, Michael H Sketch, Tracy Y Wang, E Magnus Ohman, Eric D Peterson, J Matthew Brennan
BACKGROUND: Recent randomized evidence has demonstrated benefit with complete revascularization during the index hospitalization for multivessel coronary artery disease ST-segment elevation myocardial infarction (STEMI) patients; however, this benefit likely depends on the risk of future major adverse cardiovascular events (MACE). METHODS: Using data from Duke University Medical Center (2003-2012), we identified those at high risk for 1-year MACE among 664 STEMI patients with conservatively managed non-infarct-related artery (non-IRA) lesions...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29222713/comparative-analysis-of-lactic-acidosis-induced-by-linezolid-and-vancomycin-therapy-using-cohort-and-case-control-studies-of-incidence-and-associated-risk-factors
#11
Nobuaki Mori, Yoshio Kamimura, Yuki Kimura, Shoko Hirose, Yasuko Aoki, Seiji Bito
PURPOSE: Lactic acidosis is a rare complication of linezolid (LZD) therapy, and its incidence and risk factors remain unknown. This study aimed to compare the incidence of LZD-associated lactic acidosis (LALA) and vancomycin (VAN)-associated lactic acidosis (VALA) and investigate the risk factors for LALA. METHODS: We performed a retrospective cohort study using propensity score-matched analyses comparing the incidence of lactic acidosis between LZD and VAN therapy...
December 8, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29222278/safety-profiles-of-novel-agent-therapies-in-cll
#12
REVIEW
Inhye E Ahn, Matthew S Davids
A 70-year-old man with relapsed/refractory chronic lymphocytic leukemia has multiple comorbidities including atrial fibrillation (on warfarin for anticoagulation), irritable bowel syndrome, and chronic renal insufficiency. Two years ago, he received bendamustine and rituximab as first-line therapy for chronic lymphocytic leukemia and achieved partial response, but now has relapsed. Fluorescence in situ hybridization cytogenetics reveals deletion 17p. Which novel agent would you recommend for this patient?
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221961/prevalence-of-high-on-treatment-aspirin-and-clopidogrel-platelet-reactivity-in-patients-with-critical-limb-ischemia
#13
Leonardo C Clavijo, Noor Al-Asady, Ashwat Dhillon, Ray V Matthews, Jorge Caro, Han Tun, Vincent Rowe, David M Shavelle
OBJECTIVES: The goal of this study is to establish the prevalence of high on-treatment platelet reactivity to aspirin (HPRA) and clopidogrel (HPRC) in patients with critical limb ischemia (CLI). BACKGROUND: CLI is associated with an increased risk of death and cardiovascular events. Unlike other patient populations with atherosclerotic cardiovascular disease, previous studies failed to demonstrate a benefit of antiplatelet therapy in patients with CLI. METHODS: From June 2014 to November 2016, we performed platelet reactivity studies for P2Y12 and thromboxane A2 (TXA2) inhibition in 100 CLI patients receiving daily treatment with aspirin and clopidogrel...
October 28, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29221652/-acyclovir-resistant-perineal-hsv-infection-revealing-chronic-lymphoid-leukaemia
#14
E A Casassa, P Nicol, R Viraben, C Gaudin, C Bulai Livideanu, C Mengelle, L Lamant, F Fortenfant, C Paul, M P Konstantinou
BACKGROUND: Chronic HSV infection is a cause of chronic perineal ulcerations. We report a case of a chronic and refractory HSV infection revealing chronic lymphoid leukaemia. PATIENTS AND METHODS: An 85-year-old woman with an 8-month history of chronic perineal ulcerations was referred to our dermatology department. She had no previous medical history of herpes infection. Skin biopsies ruled out carcinoma but were consistent with HSV infection. A local swab was positive for HSV2...
December 5, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29217397/-development-of-methods-to-evaluate-nephrological-screening-and-support-measures-and-lessons-learned-from-the-styrian-nephrological-screening-program-niere-sch%C3%A3-tzen
#15
Stephanie Poggenburg, Klaus Jeitler, Thomas Semlitsch, Florian Stigler, Peter Krisper, Alexander Rosenkranz, Andrea Siebenhofer
Throughout the world, the incidence and prevalence of patients with chronic kidney disease have been steadily rising. In 2016, the Styrian nephrology awareness program "niere.schützen" ("Kidney Protection") was launched to early identify patients with renal insufficiency. The aim of this study was to search for existing international nephrological screening and support programs in order to identify possible evaluation parameters and concepts for niere.schützen. A search in MEDLINE® revealed five relevant international programs from four countries...
December 4, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29217305/longitudinal-weight-change-during-ckd-progression-and-its-association-with-subsequent-mortality
#16
Elaine Ku, Joel D Kopple, Kirsten L Johansen, Charles E McCulloch, Alan S Go, Dawei Xie, Feng Lin, L Lee Hamm, Jiang He, John W Kusek, Sankar D Navaneethan, Ana C Ricardo, Hernan Rincon-Choles, Miroslaw Smogorzewski, Chi-Yuan Hsu
BACKGROUND: Few studies have investigated the changes in weight that may occur over time among adults with the progression of chronic kidney disease (CKD). Whether such weight changes are independently associated with death after the onset of end-stage renal disease has also not been rigorously examined. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: We studied 3,933 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study, a longitudinal cohort of patients with CKD...
December 4, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29217087/evolution-of-simplified-frozen-elephant-trunk-repair-for-acute-debakey-type-i-dissection-midterm-outcomes
#17
Eric E Roselli, Jay J Idrees, Faisal G Bakaeen, Michael Z Tong, Edward G Soltesz, Stephanie Mick, Douglas R Johnston, Mathew J Eagleton, Venu Menon, Lars G Svensson
BACKGROUND: A modified technique for frozen elephant trunk (FET) repair of acute DeBakey type I dissection has evolved. Procedural modifications are described and midterm outcomes evaluated. METHODS: From 2009 to 2016, 72 patients with DeBakey type I dissection underwent emergency simplified FET. Mean age was 59 ± 15 years. Presentation included malperfusion (n = 22, 31%), rupture (n = 12, 16%), and aortic insufficiency (n = 42, 58%). Concomitant procedures included valve replacement (n = 9), root replacement (n = 11; valve sparing n = 6), cusp repair (n = 11), and valve resuspension (n = 21)...
December 4, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29215629/proton-pump-inhibitors-and-dementia-deciphering-the-data
#18
Paul Moayyedi, Maxine A Lewis
Proton pump inhibitors (PPIs) are effective and suppressing acid, and therefore have efficacy against gastric acid-related disorders. The long-term safety of PPIs is less clear and there have been a number of studies raising concerns regarding risk of pneumonia, fracture, Clostridium difficile, chronic renal failure, and dementia. This latter concern is addressed by a study in this issue of AJG using health care registry data and found there was no association between PPI use and Alzheimer's dementia. Furthermore, there was no increased risk of dementia with long-term use of PPIs or higher doses of PPIs...
December 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29211858/iohexol-plasma-clearance-simplified-by-dried-blood-spot-testing
#19
Sergio Luis-Lima, Flavio Gaspari, Natalia Negrín-Mena, Fabiola Carrara, Laura Díaz-Martín, Alejandro Jiménez-Sosa, Federico González-Rinne, Armando Torres, Esteban Porrini
Background: Renal function can be estimated with formulas, which are inaccurate, or measured with gold standard methods, which are reliable but unpractical. We propose to simplify the plasma clearance of iohexol, a gold standard method to measure renal function, by dried blood spot (DBS) testing. Methods: We compared glomerular filtration rate (GFR) values assessed by DBS and the reference plasma analysis technique. We tested in vitro the agreement between non-volumetric and volumetric DBS with the reference technique...
December 4, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29209980/predictors-of-increased-length-of-hospital-stay-following-laparoscopic-sleeve-gastrectomy-from-the-national-surgical-quality-improvement-program
#20
Reid Fletcher, Rebecca Deal, John Kubasiak, Alfonso Torquati, Philip Omotosho
BACKGROUND: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure in the USA. Identifying preoperative risk factors for prolonged postoperative hospital stay will help appropriately select patients for fast-track protocols and avoid costly readmissions. To date, there has been no large national database analysis of risk factors for prolonged length of stay following laparoscopic sleeve gastrectomy. METHODS: Laparoscopic sleeve gastrectomy procedures reported to the American College of Surgeons National Surgical Quality Improvement Program between 2009 and 2012 were reviewed...
December 5, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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