keyword
https://read.qxmd.com/read/38419819/variation-in-multimorbidity-by-sociodemographics-and-social-drivers-of-health-among-patients-seen-at-community-based-health-centers
#21
JOURNAL ARTICLE
Wyatt P Bensken, Suparna M Navale, Brenda M McGrath, Nicole Cook, Yui Nishiike, Gretchen Mertes, Rose Goueth, Matthew Jones, Anna Templeton, Stephen J Zyzanski, Siran M Koroukian, Kurt C Stange
PURPOSE: Understanding variation in multimorbidity across sociodemographics and social drivers of health is critical to reducing health inequities. METHODS: From the multi-state OCHIN network of community-based health centers (CBHCs), we identified a cross-sectional cohort of adult (> 25 years old) patients who had a visit between 2019-2021. We used generalized linear models to examine the relationship between the Multimorbidity Weighted Index (MWI) and sociodemographics and social drivers of health (Area Deprivation Index [ADI] and social risks [e...
2024: J Multimorb Comorb
https://read.qxmd.com/read/38418901/comprehensive-characterization-of-ifn%C3%AE-signaling-in-acute-myeloid-leukemia-reveals-prognostic-and-therapeutic-strategies
#22
JOURNAL ARTICLE
Bofei Wang, Patrick K Reville, Mhd Yousuf Yassouf, Fatima Z Jelloul, Christopher Ly, Poonam N Desai, Zhe Wang, Pamella Borges, Ivo Veletic, Enes Dasdemir, Jared K Burks, Guilin Tang, Shengnan Guo, Araceli Isabella Garza, Cedric Nasnas, Nicole R Vaughn, Natalia Baran, Qing Deng, Jairo Matthews, Preethi H Gunaratne, Dinler A Antunes, Suhendan Ekmekcioglu, Koji Sasaki, Miriam B Garcia, Branko Cuglievan, Dapeng Hao, Naval Daver, Michael R Green, Marina Konopleva, Andrew Futreal, Sean M Post, Hussein A Abbas
Interferon gamma (IFNγ) is a critical cytokine known for its diverse roles in immune regulation, inflammation, and tumor surveillance. However, while IFNγ levels were elevated in sera of most newly diagnosed acute myeloid leukemia (AML) patients, its complex interplay in AML remains insufficiently understood. We aim to characterize these complex interactions through comprehensive bulk and single-cell approaches in bone marrow of newly diagnosed AML patients. We identify monocytic AML as having a unique microenvironment characterized by IFNγ producing T and NK cells, high IFNγ signaling, and immunosuppressive features...
February 28, 2024: Nature Communications
https://read.qxmd.com/read/38418609/influence-of-co-mutational-patterns-in-disease-phenotype-and-clinical-outcomes-of-chronic-myelomonocytic-leukemia
#23
JOURNAL ARTICLE
Guillermo Montalban-Bravo, Juan Jose Rodriguez-Sevilla, David Michael Swanson, Rashmi Kanagal-Shamanna, Danielle Hammond, Kelly Chien, Koji Sasaki, Elias Jabbour, Courtney DiNardo, Koichi Takahashi, Nicholas Short, Ghayas C Issa, Naveen Pemmaraju, Tapan Kadia, Farhad Ravandi, Naval Daver, Gautam Borthakur, Sanam Loghavi, Sherry Pierce, Carlos Bueso-Ramos, Hagop Kantarjian, Guillermo Garcia-Manero
No abstract text is available yet for this article.
February 28, 2024: Leukemia
https://read.qxmd.com/read/38418394/paired-single-b-cell-transcriptomics-and-receptor-sequencing-reveal-activation-states-and-clonal-signatures-that-characterize-b-cells-in-acute-myeloid-leukemia
#24
JOURNAL ARTICLE
Shengnan Guo, Gopi S Mohan, Bofei Wang, Tianhao Li, Naval Daver, Yuting Zhao, Patrick K Reville, Dapeng Hao, Hussein A Abbas
BACKGROUND: Acute myeloid leukemia (AML) is associated with a dismal prognosis. Immune checkpoint blockade (ICB) to induce antitumor activity in AML patients has yielded mixed results. Despite the pivotal role of B cells in antitumor immunity, a comprehensive assessment of B lymphocytes within AML's immunological microenvironment along with their interaction with ICB remains rather constrained. METHODS: We performed an extensive analysis that involved paired single-cell RNA and B-cell receptor (BCR) sequencing on 52 bone marrow aspirate samples...
February 28, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38411006/efficient-and-metal-free-synthesis-of-2-aroyl-7-azaindoles-via-thermally-induced-denitrogenative-intramolecular-annulation-of-1-2-3-4-tetrazolopyridines
#25
JOURNAL ARTICLE
Chirag A Chamakiya, Savankumar R Chothani, Rupal J Joshi, Jasmin Bhalodia, Mrunal A Ambasana, Atul H Bapodra, Naval Kapuriya
A facile and metal-free intramolecular denitrogenative annulation strategy for the preparation of novel 2-aroyl 7-azaindoles has been developed from 3-(tetrazolo[1,5- a ]pyridin-8-yl)prop-2-en-1-one in the presence of the deep eutectic solvent Dowtherm A. The valuable features of the protocol include a short reaction time, absence of any metal catalyst, utilization of a eutectic solvent, easy product isolation, and very good yields of novel 2-aroyl 7-azaindoles.
February 27, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38406181/mitigating-the-covid-19-pandemic-through-data-driven-resource-sharing
#26
JOURNAL ARTICLE
Esmaeil Keyvanshokooh, Mohammad Fattahi, Kenneth A Freedberg, Pooyan Kazemian
COVID-19 outbreaks in local communities can result in a drastic surge in demand for scarce resources such as mechanical ventilators. To deal with such demand surges, many hospitals (1) purchased large quantities of mechanical ventilators, and (2) canceled/postponed elective procedures to preserve care capacity for COVID-19 patients. These measures resulted in a substantial financial burden to the hospitals and poor outcomes for non-COVID-19 patients. Given that COVID-19 transmits at different rates across various regions, there is an opportunity to share portable healthcare resources to mitigate capacity shortages triggered by local outbreaks with fewer total resources...
February 2024: Naval research logistics
https://read.qxmd.com/read/38403505/azacitidine-post-transplant-maintenance-improves-disease-progression-in-high-risk-acute-myeloid-leukemia-and-myelodysplastic-syndrome
#27
JOURNAL ARTICLE
Oren Pasvolsky, Rima M Saliba, Uday R Popat, Amin Alousi, Rohtesh Mehta, Jason Yeh, Gheath Al-Atrash, Masood Adeel, Jeremy Ramdial, David Marin, Gabriela Rondon, Partow Kebriaei, Richard Champlin, Naval Daver, Courtney Dinardo, Nicholas J Short, Elizabeth J Shpall, Betül Oran
BACKGROUND: Maintenance after allogeneic hematopoietic cell transplantation (alloHCT) with hypomethylating agents has yielded conflicting results. MATERIALS AND METHODS: We conducted a single center retrospective matched-control analysis with the study group (5-azacitidine [AZA] group) including adults with FLT3-negative acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who received post-transplant AZA maintenance off clinical trial (n = 93). A matched control group was comprised of contemporaneous AML/MDS patients who did not receive any maintenance (n = 357)...
February 3, 2024: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/38391202/single-cell-cd4-and-cd8-t-cell-secretome-profiling-reveals-temporal-and-niche-differences-in-acute-myeloid-leukemia-following-immune-checkpoint-blockade-therapy
#28
JOURNAL ARTICLE
Jessica L Root, Poonam N Desai, Christopher Ly, Bofei Wang, Fatima Zahra Jelloul, Jing Zhou, Sean Mackay, Mansour Alfayez, Jairo Matthews, Sherry Pierce, Patrick K Reville, Naval Daver, Hussein A Abbas
Acute myeloid leukemia (AML) is a heterogeneous malignancy of the blood primarily treated with intensive chemotherapy. The allogeneic T cell anti-leukemic activity via donor lymphocyte infusions and stem cell transplantation suggests a potential role for checkpoint blockade therapy in AML. While clinical trials employing these treatments have fallen short of expected results, a deeper exploration into the functional states of T cells in AML could bridge this knowledge gap. In this study, we analyzed the polyfunctional activity of T cells in a cohort of relapsed/refractory (RelRef) AML patients treated on the clinical trial (ClinicalTrials...
February 23, 2024: Cancer Res Commun
https://read.qxmd.com/read/38388812/genome-sequencing-and-analysis-of-penicillin-v-producing-penicillium-rubens-strain-bioncl-p45-isolated-from-india
#29
JOURNAL ARTICLE
Amol M Sawant, Vishwambar D Navale, Koteswara Rao Vamkudoth
BACKGROUND: A filamentous fungus Penicillium rubens is widely recognized for producing industrially important antibiotic, penicillin at industrial scale. OBJECTIVE: To better comprehend, the genetic blueprint of the wild-type P. rubens was isolated from India to identify the genetic/biosynthetic pathways for phenoxymethylpenicillin (penicillin V, PenV) and other secondary metabolites. METHOD: Genomic DNA (gDNA) was isolated, and library was prepared as per Illumina platform...
February 22, 2024: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/38387353/complexity-functioning-relationships-differ-across-different-environmental-conditions
#30
JOURNAL ARTICLE
Mariana Mayer-Pinto, Amelia Caley, Antony M Knights, Laura Airoldi, Melanie J Bishop, Paul Brooks, Ricardo Coutinho, Tasman Crowe, Paolo Mancuso, Lais P D Naval-Xavier, Louise B Firth, Rafael Menezes, Luciana V R de Messano, Rebecca Morris, Donald J Ross, Joanne X W Wong, Peter Steinberg, Elisabeth M A Strain
Habitat complexity is widely considered an important determinant of biodiversity, and enhancing complexity can play a key role in restoring degraded habitats. However, the effects of habitat complexity on ecosystem functioning - as opposed to biodiversity and community structure - are relatively poorly understood for artificial habitats, which dominate many coastlines. With Greening of Grey Infrastructure (GGI) approaches, or eco-engineering, increasingly being applied around the globe, it is important to understand the effects that modifying habitat complexity has on both biodiversity and ecological functioning in these highly modified habitats...
February 21, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38384631/effect-of-hyaluronic-acid-containing-transfer-media-embryoglue%C3%A2-on-the-live-birth-rate-in-frozen-thawed-embryo-transfer-cycles
#31
JOURNAL ARTICLE
Nihar R Bhoi, Nitiz Murdia, Kshitiz Murdia, Vipin Chandra, Isha Suwalka, Walmik Mistari, Ritesh Aggrawal, Naval Shah, Dayanidhi Kumar
This retrospective cohort study examines the impact of EmbryoGlue® - a culture medium comprising high-concentration hyaluronan and low-concentration recombinant human albumin (rHA) - on assisted reproductive technology (ART) outcomes in 1,298 cycles across 13 centers. The study focused on live birth rates, clinical pregnancy, and miscarriage rates between a standard treatment arm and an EmbryoGlue® arm in frozen embryo transfer (FET) cycles. Propensity score matching ensured comparable baseline variables...
January 2024: Curēus
https://read.qxmd.com/read/38378362/venetoclax-and-cobimetinib-in-relapsed-refractory-aml-a-phase-1b-trial
#32
JOURNAL ARTICLE
Marina Y Konopleva, Monique Dail, Naval G Daver, Jacqueline S Garcia, Brian A Jonas, Karen W L Yee, Kevin R Kelly, Norbert Vey, Sarit Assouline, Gail J Roboz, Stefania Paolini, Daniel A Pollyea, Agostino Tafuri, Joseph M Brandwein, Arnaud Pigneux, Bayard L Powell, Pierre Fenaux, Rebecca L Olin, Giuseppe Visani, Giovanni Martinelli, Maika Onishi, Jue Wang, Weize Huang, Diana Dunshee, Habib Hamidi, Marion G Ott, Wan-Jen Hong, Michael Andreeff
BACKGROUND: Therapies for relapsed/refractory acute myeloid leukemia remain limited and outcomes poor, especially amongst patients who are ineligible for cytotoxic chemotherapy or targeted therapies. PATIENTS AND METHODS: This phase 1b trial evaluated venetoclax, a B-cell lymphoma-2 (BCL-2) inhibitor, plus cobimetinib, a MEK1/2 inhibitor, in patients with relapsed/refractory acute myeloid leukemia, ineligible for cytotoxic chemotherapy. Two-dimensional dose-escalation was performed for venetoclax dosed daily, and for cobimetinib dosed on days 1-21 of each 28-day cycle...
January 18, 2024: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/38373046/maritime-applications-of-prolonged-casualty-care-a-series-introduction
#33
JOURNAL ARTICLE
Matthew D Tadlock, Levi K Kitchen, Jeremy J Brower, Michael S Tripp
The current United States Navy and North Atlantic Treaty Organization (NATO) maritime strategy is coalescing around the concept of Distributed Maritime Operations (DMOs) to prepare for future large-scale combat operations with peer or near-peer competitors. As a result, individual components of naval forces will be more geographically dispersed and oper- ating at a significant time and distance from higher levels of medical care. We developed a series of educational scenarios informed by real-world events to enhance the ability of Role 1 medical caregivers to apply the principles of Prolonged Ca- sualty Care during current routine, crisis, and contingency DMOs...
February 19, 2024: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://read.qxmd.com/read/38354738/wnt-dose-escalation-during-the-exit-from-pluripotency-identifies-tranilast-as-a-regulator-of-cardiac-mesoderm
#34
JOURNAL ARTICLE
Zhixuan Wu, Sophie Shen, Dalia Mizikovsky, Yuanzhao Cao, Marina Naval-Sanchez, Siew Zhuan Tan, Yanina D Alvarez, Yuliangzi Sun, Xiaoli Chen, Qiongyi Zhao, Daniel Kim, Pengyi Yang, Timothy A Hill, Alun Jones, David P Fairlie, Alice Pébay, Alex W Hewitt, Patrick P L Tam, Melanie D White, Christian M Nefzger, Nathan J Palpant
Wnt signaling is a critical determinant of cell lineage development. This study used Wnt dose-dependent induction programs to gain insights into molecular regulation of stem cell differentiation. We performed single-cell RNA sequencing of hiPSCs responding to a dose escalation protocol with Wnt agonist CHIR-99021 during the exit from pluripotency to identify cell types and genetic activity driven by Wnt stimulation. Results of activated gene sets and cell types were used to build a multiple regression model that predicts the efficiency of cardiomyocyte differentiation...
February 9, 2024: Developmental Cell
https://read.qxmd.com/read/38340569/the-t1-dark-rim-a-novel-imaging-sign-for-detecting-smoldering-inflammation-in-multiple-sclerosis
#35
JOURNAL ARTICLE
Pablo Naval-Baudin, Albert Pons-Escoda, Albert Castillo-Pinar, Ignacio Martínez-Zalacaín, Pablo Arroyo-Pereiro, Susanie Flores-Casaperalta, Francis Garay-Buitron, Nahum Calvo, Antonio Martinez-Yélamos, Mónica Cos, Sergio Martínez-Yélamos, Carles Majós
PURPOSE: Paramagnetic rim lesions (PRLs), usually identified in susceptibility-weighted imaging (SWI), are a promising prognostic biomarker of disability progression in multiple sclerosis (MS). However, SWI is not routinely performed in clinical practice. The objective of this study is to define a novel imaging sign, the T1-dark rim, identifiable in a standard 3DT1 gradient-echo inversion-recovery sequence, such as 3D T1 turbo field echo (3DT1FE) and explore its performance as a SWI surrogate to define PRLs...
February 5, 2024: European Journal of Radiology
https://read.qxmd.com/read/38339949/an-observational-objective-job-analysis-of-role-related-tasks-undertaken-by-royal-navy-sailors
#36
JOURNAL ARTICLE
Joseph A Hogan, Steven D Powell, Hannah Gribble, Samantha Saunders, Frances Gunner, Joanne L Fallowfield, Piete E H Brown, Adrian J Allsopp
BACKGROUND: The current in-service Royal Naval Fitness Test has two elements to test the aerobic endurance and muscular strength of Service Personnel through generic field-based tests and a short job task simulation. However, in 2017 the Royal Navy (RN) identified a requirement to update their in-service fitness test to align with international best practice. OBJECTIVE: The purpose of this study was to conduct an Objective Job Task Analysis on critical, physically demanding tasks that could be undertaken by RN sailors during sea deployments...
January 7, 2024: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://read.qxmd.com/read/38330163/quantitative-analysis-of-condition-based-limited-duty-duration-of-musculoskeletal-conditions
#37
JOURNAL ARTICLE
Christopher S Smith, Laura Yoon, Julia N Zuppke, Mike Zundel
INTRODUCTION: Musculoskeletal injuries affect nearly a million service members annually within the DoD, ultimately costing the U.S. Military half a billion dollars in direct patient costs and a significant loss to fleet readiness as many members are assigned days on limited duty (LIMDU) until they are deemed medically fit to return to duty (RTD). The new approach implemented by Navy Medicine in 2022, called "condition-based LIMDU," aims to drastically impact the time in which Sailors and Marines spend under a provider's care by assigning LIMDU days based on a standardized set of guidelines...
February 6, 2024: Military Medicine
https://read.qxmd.com/read/38330092/when-a-critically-ill-child-is-oceans-away-from-a-picu-a-military-pediatric-ccat-mission
#38
JOURNAL ARTICLE
Kevin M Brinkman, Luke Zabrocki, Noelle Cadotte, Renée I Matos
A 4-year-old former 26-week premature male presented to the U.S. Naval Hospital Guam emergency department in respiratory failure secondary to human metapneumovirus requiring urgent intubation. His condition was complicated by a bradycardic arrest requiring 15 minutes of resuscitation before the return of circulation. He was admitted to the adult intensive care unit and was managed via pediatric telecritical care from San Diego. He developed acute respiratory distress syndrome, acute renal failure, hypotension requiring multiple pressors, and fluid overload necessitating bilateral chest tubes and two peritoneal drains...
February 5, 2024: Military Medicine
https://read.qxmd.com/read/38316133/oral-decitabine-plus-cedazuridine-and-venetoclax-in-patients-with-higher-risk-myelodysplastic-syndromes-or-chronic-myelomonocytic-leukaemia-a-single-centre-phase-1-2-study
#39
JOURNAL ARTICLE
Alex Bataller, Guillermo Montalban-Bravo, Alexandre Bazinet, Yesid Alvarado, Kelly Chien, Sangeetha Venugopal, Jo Ishizawa, Danielle Hammond, Mahesh Swaminathan, Koji Sasaki, Ghayas C Issa, Nicholas J Short, Lucia Masarova, Naval G Daver, Tapan M Kadia, Simona Colla, Wei Qiao, Xuelin Huang, Rashmi Kanagal-Shamanna, Stephany Hendrickson, Farhad Ravandi, Elias Jabbour, Hagop Kantarjian, Guillermo Garcia-Manero
BACKGROUND: Hypomethylating agents are approved in higher-riskmyelodysplastic syndromes. The combination of a hypomethylating agent with venetoclax is standard of care in acute myeloid leukaemia. We investigated the safety and activity of the first totally oral combination of decitabine plus cedazuridine and venetoclax in patients with higher-risk-myelodysplastic syndromes and chronic myelomonocytic leukaemia. METHODS: We did a single-centre, dose-escalation and dose-expansion, phase 1/2, clinical trial...
February 2, 2024: Lancet Haematology
https://read.qxmd.com/read/38308924/association-between-abdominal-adiposity-and-cognitive-decline-in-older-adults-a-10-year-community-based-study
#40
JOURNAL ARTICLE
Kazuaki Uchida, Taiki Sugimoto, Chikako Tange, Yukiko Nishita, Hiroshi Shimokata, Naoki Saji, Yujiro Kuroda, Nanae Matsumoto, Yoshinobu Kishino, Rei Ono, Toshihiro Akisue, Rei Otsuka, Takashi Sakurai
OBJECTIVES: This study aimed to investigate the association between abdominal adiposity and change in cognitive function in community-dwelling older adults. DESIGN, SETTING, AND PARTICIPANTS: This longitudinal study included older adults aged ≥60 years without cognitive impairment who participated in the National Institute for Longevity Sciences - Longitudinal Study of Aging. MEASUREMENTS: Cognitive function was evaluated biennially using the Mini-Mental State Examination (MMSE) over 10 years...
February 2, 2024: Journal of Nutrition, Health & Aging
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