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https://www.readbyqxmd.com/read/28324773/haptoglobin-is-frequently-low-in-patients-with-myelofibrosis-clinical-relevance
#1
Paolo Strati, Lucia Masarova, Prithviraj Bose, Naval Daver, Naveen Pemmaraju, Srdan Verstovsek
A recent study, showing the absence of paroxysmal nocturnal hemoglobinuria clones in myelofibrosis, has reopened the debate around the role of decreased haptoglobin in this disease. We present here a large prospective analysis of the clinical significance of low haptoglobin in 152 patients with myelofibrosis. Low haptoglobin (<32mg/dL) was observed in 50 patients (33%). Decreased haptoglobin did not associate with low hemoglobin levels, positive Coombs test or abnormal liver function tests, suggesting it is not result of autoimmune hemolytic anemia or liver cirrhosis...
March 8, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28323584/evidence-for-gz-adaptation-observed-with-wearable-biosensors-during-high-performance-jet-flight
#2
G Merrill Rice, Dallas Snider, Jeffrey L Moore, J Timothy Lavan, Rich Folga, Thomas B VanBrunt
INTRODUCTION: Few studies have evaluated physiological responses to high acceleration forces during actual flight and to our knowledge no normative data has been acquired by technologies such as wearable biosensors during high performance jet aircraft operations. METHODS: In-flight physiological data from an FDA cleared portable triaxial accelerometer and bio-sensor were observed from five active duty F-18 pilots of the Naval Flight Demonstration Squadron (Blue Angels)...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28301394/effects-on-the-anti-abo-titers-of-military-blood-donors-from-a-predeployment-vaccination-program
#3
Olle Berséus
BACKGROUND: The use of blood group O as "universal blood" for emergency whole blood transfusions carries the risk for a hemolytic transfusion reaction mediated by incompatible A-/B-antibodies. This risk can be minimized by assuring that the donor has a low titer of anti-A and anti-B. The level of these naturally occurring antibodies have been shown to be increased by vaccination with most biologically derived vaccines. This boostering effect has been investigated for the new generation of vaccines...
March 15, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28291447/an-orthopedic-performance-improvement-initiative-at-a-small-military-treatment-facility
#4
John Christopher McGee, Christopher G Bise, Joel M Stevens
OBJECTIVES: The scientific literature demonstrates a cost-benefit associated with early access to physical therapy. The purpose of this case study is to report the results of an orthopedic performance improvement initiative (OPII) at a small military treatment facility (approximately 4.5K active duty beneficiaries). The OPII was introduced to (1) limit variation by ensuring that all active duty orthopedic consults were audited ensuring proper timing of appropriate services and (2) establish contractual agreement for shared resources with the U...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290981/case-report-of-clinical-vignette-osteopetrosis
#5
John B Moore, Thanh D Hoang, Alfred F Shwayhat
INTRODUCTION: Osteopetrosis is a connective tissue disorder resulting from abnormally dense bone predisposing patients to fracture. The clinical pattern of fractures across time and space as well as suggestive radiographic findings usually raises diagnostic suspicion. Multiple genetic mutations resulting in dysfunctional osteoclasts have been implicated in the pathogenesis of osteopetrosis with variable inheritance patterns. In severe cases, usually inherited in an autosomal recessive pattern, the medullary cavity important in the production of normal blood cell progenitors is replaced by defective endochondral bone, leading to pancytopenia and consequential extramedullary hematopoiesis...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28284483/tactical-combat-casualty-care-beginnings
#6
REVIEW
Frank K Butler
Tactical Combat Casualty Care (TCCC) is a set of evidence-based, best-practice prehospital trauma care guidelines customized for use on the battlefield. The origins of TCCC were nontraditional. The TCCC program began as a Naval Special Warfare biomedical research effort launched after the realization that extremity hemorrhage, a leading cause of preventable death on the battlefield, was not being treated with a readily available and highly effective intervention: the tourniquet. This insight prompted a systematic reevaluation of all aspects of battlefield trauma care that was conducted from 1993 to 1996 as a joint effort by special operations medical personnel and the Uniformed Services University of the Health Sciences...
March 8, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28273113/application-of-the-pj-and-nps-evaporation-duct-models-over-the-south-china-sea-scs-in-winter
#7
Shaobo Yang, Xingfei Li, Chao Wu, Xin He, Ying Zhong
The detection of duct height has a significant effect on marine radar or wireless apparatus applications. The paper presents two models to verify the adaptation of evaporation duct models in the SCS in winter. A meteorological gradient instrument used to measure evaporation ducts was fabricated using hydrological and meteorological sensors at different heights. An experiment on the adaptive characteristics of evaporation duct models was carried out over the SCS. The heights of the evaporation ducts were measured by means of log-linear fit, Paulus-Jeske (PJ) and Naval Postgraduate School (NPS) models...
2017: PloS One
https://www.readbyqxmd.com/read/28271150/german-water-infrastructure-in-china-colonial-qingdao-1898-1914
#8
Agnes Kneitz
Within the colorful tapestry of colonial possessions the German empire acquired over the short period of its existence, Qingdao stands out because it fulfilled a different role from settlements in Africa-especially because of its exemplary planned water infrastructure: its technological model, the resulting (public) hygiene, and the adjunct brewery. The National Naval Office (Reichsmarineamt), which oversaw the administration of the future "harbour colony"-at first little more than a little fishing village-enjoyed a remarkable degree of freedom in implementing this project...
March 7, 2017: NTM
https://www.readbyqxmd.com/read/28246192/greater-than-one-tp53-abnormality-is-a-dominant-characteristic-of-pure-erythroid-leukemia
#9
Guillermo Montalban-Bravo, Christopher B Benton, Sa A Wang, Farhad Ravandi, Tapan Kadia, Jorge Cortes, Naval Daver, Koichi Takahashi, Courtney DiNardo, Elias Jabbour, Gautam Borthakur, Marina Konopleva, Sherry Pierce, Carlos Bueso-Ramos, Keyur Patel, Steven Kornblau, Hagop Kantarjian, Ken H Young, Guillermo Garcia-Manero, Michael Andreeff
No abstract text is available yet for this article.
February 28, 2017: Blood
https://www.readbyqxmd.com/read/28245856/characterization-of-oral-and-gut-microbiome-temporal-variability-in-hospitalized-cancer-patients
#10
Jessica R Galloway-Peña, Daniel P Smith, Pranoti Sahasrabhojane, W Duncan Wadsworth, Bryan M Fellman, Nadim J Ajami, Elizabeth J Shpall, Naval Daver, Michele Guindani, Joseph F Petrosino, Dimitrios P Kontoyiannis, Samuel A Shelburne
BACKGROUND: Understanding longitudinal variability of the microbiome in ill patients is critical to moving microbiome-based measurements and therapeutics into clinical practice. However, the vast majority of data regarding microbiome stability are derived from healthy subjects. Herein, we sought to determine intra-patient temporal microbiota variability, the factors driving such variability, and its clinical impact in an extensive longitudinal cohort of hospitalized cancer patients during chemotherapy...
February 28, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28244572/anti-aging-effect-of-riboflavin-via-endogenous-antioxidant-in-fruit-fly-drosophila-melanogaster
#11
Y-X Zou, M-H Ruan, J Luan, X Feng, S Chen, Z-Y Chu
OBJECTIVES: This study investigated the effect of riboflavin on aging in Drosophila melanogaster (fruit fly). DESIGN: Experimental study. SETTING: Naval Medical Research Institute. PARTICIPANTS: Fruit fly Drosophila melanogaster. INTERVENTION: After lifelong supplement of riboflavin, the lifespan and the reproduction of fruit flies were observed. Hydrogen peroxide (H2O2) was used to mimic oxidative stress damage to fruit flies and the survival time was recorded...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28239712/pseudocapacitive-performance-of-a-solution-processed-%C3%AE-co-oh-2-electrode-monitored-through-its-surface-morphology-and-area
#12
P S Gaikar, S T Navale, S L Gaikwad, Ahmed Al-Osta, V V Jadhav, P R Arjunwadkar, Mu Naushad, Rajaram S Mane
In the present study, beta-cobalt hydroxide (β-Co(OH)2) electrodes of various nanostructures and surface areas, viz. nano-rhombuses (NRs), nano-plates (NPs), and nano-grass (NGs), have been synthesized directly onto a stainless-steel (SS) substrate using a simple, economical and binder-free chemical solution-process, utilizing three cobalt precursor salts, i.e. cobalt acetate, cobalt chloride, and cobalt nitrate, respectively. Structural elucidation proves the crystallite size, type and phase-purity of β-Co(OH)2, whereas the surface morphology analysis supports the evolution of the above mentioned nanostructures of various surface areas...
February 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28235550/a-10-year-retrospective-review-of-nephrolithiasis-in-the-navy-and-navy-pilots
#13
James H Masterson, Christopher J Phillips, Nancy F Crum-Cianflone, Robert J Krause, Roger L Sur, James O L'Esperance
PURPOSE: Little is known about the incidence of nephrolithiasis in the U.S. Navy, and Navy pilots must be kidney stone-free and are often referred for treatment of small asymptomatic stones. The primary objectives of this study were to determine the incidence of nephrolithiasis, CT scans performed, proportion undergoing treatment, and incidence of stone-related mishaps of Navy pilots compared with other Navy personnel. MATERIALS AND METHODS: We performed a retrospective study of all Navy service members from 2002-2011 for nephrolithiasis (based on ICD-9 stone codes) to determine the above rates, and reviewed Naval Safety Center (NSC) data for a history of accidents associated with nephrolithiasis...
February 21, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28230450/characteristics-and-medication-use-of-psoriasis-patients-who-may-or-may-not-qualify-for-randomized-controlled-trials
#14
William Malatestinic, Beth Nordstrom, Jashin J Wu, Orin Goldblum, Kathleen Solotkin, Chen-Yen Lin, Kristin Kistler, Kathy Fraeman, Joseph Johnston, Lcdr Lesley Hawley, Nicholas Sicignano, Andre Araujo
BACKGROUND: Clinical trials impose exclusion criteria that may limit the generalizability of results. OBJECTIVES: To (a) determine the percentage of real-world patients who would qualify for psoriasis randomized controlled trials; (b) ascertain differences between moderate-to-severe psoriasis patients who would be eligible, ineligible, or potentially eligible for clinical trials; and (c) compare their biologic treatment patterns. METHODS: Moderate-to-severe psoriasis patients were identified from the U...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28214404/malignancy-associated-haemophagocytic-lymphohistiocytosis-in-adults
#15
Naval Daver, Hagop Kantarjian
No abstract text is available yet for this article.
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28188891/3-2-deoxy-%C3%AE-d-erythro-pentafuranosyl-pyrimido-1-2-%C3%AE-purin-10-3h-one-deoxyguanosine-adducts-of-workers-exposed-to-asbestos-fibers
#16
Stefano Bonassi, Filippo Cellai, Armelle Munnia, Donatella Ugolini, Alfonso Cristaudo, Monica Neri, Mirta Milić, Alessandra Bonotti, Roger W Giese, Marco E M Peluso
Asbestos is the commercial name for a group of silicate minerals naturally occurring in the environment and widely used in the industry. Asbestos exposure has been associated with pulmonary fibrosis, mesothelioma, and malignancies, which may appear after a period of latency of 20-40 years. Mechanisms involved in the carcinogenic effects of asbestos are still not fully elucidated, although the oxidative stress theory suggests that phagocytic cells produce large amounts of reactive oxygen species, due to their inability to digest asbestos fiber...
March 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28174667/evaluating-the-feasibility-of-a-web-based-weight-loss-programme-for-naval-service-personnel-with-excess-body-weight
#17
Gulcan Garip, Kate Morton, Robert Bridger, Lucy Yardley
BACKGROUND: Overweight and obesity are a major concern that may influence the operational capacity of the UK Naval Service (NS). This study was conducted to evaluate the feasibility of trialling and implementing a modified web-based weight loss programme for overweight and obese NS personnel. METHODS: The feasibility of a web-based weight loss programme with minimal face to face support was evaluated using a non-randomised design, based on the Reach, Efficacy, Adoption, and Implementation (RE-AIM) dimensions of a framework designed for analysing implementation of interventions in practice...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28171804/hemodynamic-and-neuro-monitoring-for-neurocritically-ill-patients-an-international-survey-of-intensivists
#18
Sanjeev Sivakumar, Fabio S Taccone, Mohammed Rehman, Holly Hinson, Neeraj Naval, Christos Lazaridis
PURPOSE: To investigate multimodality systemic and neuro-monitoring practices in acute brain injury (ABI) and to analyze differences among "neurointensivists" (NI; clinical practice comprised >1/3 by neurocritical care), and other intensivists (OI). METHODS: Anonymous 22-question Web-based survey among physician members of SCCM and ESICM. RESULTS: Six hundred fifty-five responded (66% completion rate); 422 (65%) were OI, and 226 (35%) were NI...
January 21, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28167165/the-use-of-a-custom-made-mouthguard-stabilizes-the-electromyographic-activity-of-the-masticatory-muscles-among-karate-d%C3%A5-athletes
#19
Gilsane Raquel, Eli Luis Namba, Daniel Bonotto, Edvaldo Antônio Ribeiro Rosa, Paula Cristina Trevilatto, Maria Ângela Naval Machado, Michelle Santos Vianna-Lara, Luciana Reis Azevedo-Alanis
AIMS: To analyze and compare the electromyographic activity of the temporal (anterior portion) and masseter muscles among Karate-Dō athletes before and after training, with and without the use of a mouthguard. METHODS: Twenty athletes (14 males and 6 females) with a mean age of 23.7 ± 7.5 years participated. They had surface electromyography recordings taken of their bilateral temporal and masseter muscles before and after training under the following conditions: no mouthguard, with a ready-made mouthguard, and with a custom-made mouthguard...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28157461/multidrug-resistant-tuberculosis-patients-views-of-interventions-to-reduce-treatment-loss-to-follow-up
#20
T Tupasi, A M C G Garfin, J M Mangan, R Orillaza-Chi, L C Naval, G I Balane, R Basilio, A Golubkov, E S Joson, W-J Lew, V Lofranco, M Mantala, S Pancho, J N Sarol, A Blumberg, D Burt, E V Kurbatova
SETTING: Patients who initiated treatment for multidrug-resistant tuberculosis (MDR-TB) at 15 Programmatic Management of Drug-resistant Tuberculosis (PMDT) health facilities in the Philippines between July and December 2012. OBJECTIVES: To describe patients' views of current interventions, and suggest changes likely to reduce MDR-TB loss to follow-up. METHODS: In-depth interviews were conducted between April and July 2014 with MDR-TB patients who were undergoing treatment, had finished treatment at the time of the interview (controls), or had been lost to follow-up (LTFU)...
January 1, 2017: International Journal of Tuberculosis and Lung Disease
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