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https://www.readbyqxmd.com/read/28621800/a-consensus-review-on-malignancy-associated-hemophagocytic-lymphohistiocytosis-in-adults
#1
REVIEW
Naval Daver, Kenneth McClain, Carl E Allen, Sameer A Parikh, Zaher Otrock, Cristhiam Rojas-Hernandez, Boris Blechacz, Sa Wang, Milen Minkov, Michael B Jordan, Paul La Rosée, Hagop M Kantarjian
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune activation and dysregulation resulting in extreme and often life-threatening inflammation. HLH has been well recognized in pediatric populations, and most current diagnostic and therapeutic guidelines are based on pediatric HLH. Recently there has been recognition of HLH in adults, especially secondary to immune deregulation by an underlying rheumatologic, infectious, or malignant condition. This review is focused on malignancy-associated HLH (M-HLH), in which possible mechanisms of pathogenesis include severe inflammation, persistent antigen stimulation by the tumor cells, and loss of immune homeostasis because of chemotherapy, hematopoietic stem cell transplantation, or infection...
June 16, 2017: Cancer
https://www.readbyqxmd.com/read/28618796/low-frequency-acoustic-properties-of-posidonia-oceanica-seagrass-leaf-blades
#2
Jay R Johnson, Gabriel R Venegas, Preston S Wilson, Jean-Pierre Hermand
The acoustics of seagrass meadows impacts naval and oceanographic sonar applications. To study this environment, a one-dimensional resonator was used to assess the low-frequency (1-5 kHz) acoustic response of the leaf blades of the Mediterranean seagrass Posidonia oceanica in water. Three separate collections of plants from Crete, Greece, and Sicily, Italy were investigated. A high consistency in effective sound speed was observed within each collection while a strong variability was observed between different collections...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28606809/animal-derived-natural-products-used-in-the-bhutanese-sowa-riga-medicine
#3
Karma Yeshi, Paolo Morisco, Phurpa Wangchuk
ETHNOPHARMACOLOGICAL RELEVANCE: Bhutan has two traditional healing systems: a folklore medicine and the Bhutanese Sowa Rigpa medicine (BSM). Three different types of ingredients namely plants, animals (and their derived products) and minerals are used for the preparation of various formulations in combined form. Animals and their derived products are vital ingredients in the preparation of numerous traditional remedies. Unlike medicinal plants, research on medicinal animals has remained largely untouched...
June 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28601551/patients-with-post-essential-thrombocythemia-and-post-polycythemia-vera-differ-from-patients-with-primary-myelofibrosis
#4
Lucia Masarova, Prithviraj Bose, Naval Daver, Naveen Pemmaraju, Kate J Newberry, Taghi Manshouri, Jorge Cortes, Hagop M Kantarjian, Srdan Verstovsek
Prognostic scoring systems for primary myelofibrosis (PMF) are not accurate in patients with post-essential thrombocythemia and post-polycythemia vera myelofibrosis (PET-MF; PPV-MF). Given the paucity of data describing the clinical characteristics, disease course and outcomes of these patients, we sought to describe and compare the clinical characteristics and outcomes of 755 patients with PMF, 181 with PPV-MF, and 163 with PET-MF referred to our institution between 1984 and 2013. The median follow-up was 31 months, and 56% (n=616) patients had died...
June 2, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28593471/effects-of-combined-exposure-to-chronic-high-fat-diet-and-arsenic-on-thyroid-function-and-lipid-profile-in-male-mouse
#5
Akram Ahangarpour, Soheila Alboghobeish, Ali Akbar Oroojan, Leila Zeidooni, Azin Samimi, Golshan Afshari
The thyroid is one of the major endocrine glands that contribute to body and fat metabolism. The present study evaluated the effects of combined exposure to chronic high-fat diet (HFD) and arsenic on thyroid function and lipid profile. In this experimental study, 72 male Naval Medical Research Institute mice were divided into six groups and fed HFD or low-fat diet (LFD) while being exposed to 25 or 50 ppm of arsenic in drinking water for 20 weeks. After 24 h of the last experimental day, blood samples were collected for hormonal and biochemical measurements...
June 8, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28573911/framing-the-transit-expeditionary-culture-and-identities-in-lieutenant-e-j-w-noble-s-caricatures-of-the-1874-transit-of-venus-expedition-to-honolulu
#6
Rebekah Higgitt
Making use of a source previously unknown to historians, this article sheds new light on the British expedition to the Sandwich Islands to observe the 1874 transit of Venus. This source, a series of caricature drawings that follow the expedition from departure to return, gives insight into expeditionary culture and the experience of a previously unremarked member of this astronomical expedition, Evelyn J.W. Noble, a career officer of the Royal Marine Artillery. It also reveals overlapping military, scientific and masculine identities, developed in dialogue with, and often deliberately subverting, more public accounts...
June 2, 2017: Annals of Science
https://www.readbyqxmd.com/read/28569703/scholars-versus-practitioners-anchor-proof-testing-and-the-birth-of-a-mixed-culture-in-eighteenth-century-france
#7
Arnaud Orain, Sylvain Laubé
In line with studies that question the conventional dichotomies between "head" and "hand," this article analyzes the emergence of a mixed naval culture, between science and technology, during the French Enlightenment. The case at issue is that of the circuitous development of an anchor proof testing protocol, an important method in the competition for maritime supremacy used at least until the first third of the nineteenth century. The story begins in the dockyard of Brest with a humble boatswain, and continues with the dissemination of his experiments thanks to prominent figures of the Naval Academy of Brest and of the Royal Academy of Sciences of Paris...
2017: Technology and Culture
https://www.readbyqxmd.com/read/28561155/hematologic-malignancies-are-associated-with-adverse-perioperative-outcomes-following-total-knee-arthroplasty
#8
Jared M Newman, Timothy C Wagner, Qais Naziri, W Trevor North, Suparna M Navale, Alison K Klika, Wael K Barsoum, Carlos A Higuera
No abstract text is available yet for this article.
May 23, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28556489/factors-associated-with-risk-of-central-nervous-system-relapse-in-patients-with-non-core-binding-factor-acute-myeloid-leukemia
#9
Elias Jabbour, Naval Guastad Daver, Nicholas James Short, Xuelin Huang, Hsiang-Chun Chen, Abhishek Maiti, Farhad Ravandi, Jorge Cortes, Simon Abi Aad, Guillermo Garcia-Manero, Zeev Estrov, Tapan Kadia, Susan O'Brien, Bouthaina Dabaja, Carlos Bueso-Ramos, Paolo Strati, Carol Bivins, Sherry Pierce, Hagop Kantarjian
Central nervous system (CNS) relapse is uncommon in patients with acute myeloid leukemia (AML) with the use of high-dose cytarabine containing chemotherapy regimens. The clinical and molecular features associated with a higher risk of CNS relapse are not well defined. We assessed the incidence and outcome of CNS relapses among 1245 patients with relapsed/refractory AML referred to our institution between 2000 and 2014. CNS leukemia relapse was observed in 51 patients (4.1%). Using a multivariate regression model and after adjusting for age, FLT3-ITD mutation (OR=2...
May 27, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28553687/malignant-mediastinal-lymphadenopathy-detected-by-endoscopic-ultrasound-and-guided-fine-needle-aspiration-in-patients-with-resectable-pancreaticobiliary-cancer
#10
Praveer Rai, Vinod Kumar, Ram Naval Rao
BACKGROUND: Resection surgery for pancreaticobiliary malignancies carries significant morbidity and mortality. Hence, preoperative assessment to exclude unresectable disease is mandatory. CT abdomen is the primary modality for staging of pancreaticobiliary cancers. However, some patients have malignant mediastinal lymphadenopathy (MML), which may be detected on endoscopic ultrasound (EUS) but not on CT scan. METHODS: We prospectively evaluated 75 consecutive patients (median age 54 years: 44 men) with a diagnosis of resectable pancreaticobiliary cancer (carcinoma gallbladder, carcinoma pancreas, cholangiocarcinoma, or periampullary carcinoma) for the presence of MML using EUS by an experienced endosonographer...
May 29, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28552251/avoidance-responses-of-minke-whales-to-1-4khz-naval-sonar
#11
Petter H Kvadsheim, Stacy DeRuiter, Lise D Sivle, Jeremy Goldbogen, Rune Roland-Hansen, Patrick J O Miller, Frans-Peter A Lam, John Calambokidis, Ari Friedlaender, Fleur Visser, Peter L Tyack, Lars Kleivane, Brandon Southall
Minke whales are difficult to study and little information exists regarding their responses to anthropogenic sound. This study pools data from behavioural response studies off California and Norway. Data are derived from four tagged animals, of which one from each location was exposed to naval sonar signals. Statistical analyses were conducted using Mahalanobis distance to compare overall changes in parameters summarising dive behaviour, avoidance behaviour, and potential energetic costs of disturbance. Our quantitative analysis showed that both animals initiated avoidance behaviour, but responses were not associated with unusual dive behaviour...
May 25, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28550940/invasive-sinonasal-lesions-from-the-nasal-fossa-and-paranasal-sinuses-to-the-endocranium
#12
REVIEW
Pablo Naval Baudin, Albert Pons Escoda, Mònica Cos Domingo, Mario Huete Naval, Carles Majós, Carles Aguilera
The aim of this work is to review the spectrum of sinonasal lesions that extend to the endocranium and to present key points that may narrow the differential diagnosis. The most frequent sinonasal lesions that extend into the endocranium are malignant; however, benign entities are not unusual. Imaging diagnosis is difficult because malignant lesions and benign entities share similar clinical, epidemiologic, and imaging features. Tumor features in relation to bone, intratumor homogeneity and structure, magnetic resonance imaging signal, along with clinical and epidemiologic aspects may allow an appropriate diagnostic focus with important management implications...
April 8, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28539147/sunlight-exposure-work-hours-caffeine-consumption-and-sleep-duration-in-the-naval-environment
#13
Nita L Shattuck, Panagiotis Matsangas
BACKGROUND: Sailors in the U.S. Navy are habitual shiftworkers, often experiencing circadian misalignment due to their irregular work/rest schedules. This study assessed the effect of sunlight exposure, work hours, and caffeinated beverage consumption on the daily sleep duration of crewmembers of a U.S. Navy ship during a 2-wk underway period. METHODS: Working in an artificially lit area with no access to sunlight during work hours, U.S. Navy crew members (N = 91) used daily logs to report their daily activity, caffeinated beverage consumption, and exposure to sunlight while off-duty; sleep was assessed by wrist-worn actigraphy...
June 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28518003/caffeine-consumption-among-naval-aviation-candidates
#14
Thomas E Sather, Ronald D Williams, Donald R Delorey, Conrad L Woolsey
INTRODUCTION: Education frequently dictates students need to study for prolonged periods of time to adequately prepare for examinations. This is especially true with aviation preflight indoctrination (API) candidates who have to assimilate large volumes of information in a limited amount of time during API training. The purpose of this study was to assess caffeine consumption patterns (frequency, type, and volume) among naval aviation candidates attending API to determine the most frequently consumed caffeinated beverage and to examine if the consumption of a nonenergy drink caffeinated beverage was related to energy drink consumption...
April 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28515766/pancreatic-protective-and-hypoglycemic-effects-of-vitex-agnus-castus-l-fruit-hydroalcoholic-extract-in-d-galactose-induced-aging-mouse-model
#15
Akram Ahangarpour, Ali Akbar Oroojan, Layasadat Khorsandi, Seyedeh Asma Najimi
D-galactose induces pancreatic disorder along with aging mouse model. Vitex agnus-castus (VAC) has potential pancreatic protective effect. Hence, this study was designed to evaluate the hypoglycemic and pancreas protective effects of VAC hydroalcoholic extract in D-galactose-induced aging female mice. In the present experimental study, 72 adult female Naval Medical Research Institute (NMRI) mice (weighing 30-35 g) were divided into 6 groups of control, VAC hydroalcoholic extract, D-galactose, D-galactose + VAC hydroalcoholic extract, aged, aged + VAC hydroalcoholic extract...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28507614/functional-pattern-of-increasing-concentrations-of-brain-derived-neurotrophic-factor-in-spiral-ganglion-implications-for-research-on-cochlear-implants
#16
Emina Ramku, Refik Ramku, Dugagjin Spanca, Valbona Zhjeqi
BACKGROUND: As previously various studies have suggested application of brain-derived neurotrophic factor (BDNF) may be considered as a promising future therapy for hearing deficits, in particular for the improvement of cochlear neurone loss during cochlear implantation. AIM: The present study's aim was to establish the upper threshold of the concentration of BDNF in Naval Medical Research Institute (NMRI) mice spiral ganglion outgrowth. METHODS: Spiral ganglion explants were prepared from post-natal day 4 (p4) (NMRI) mice of both sexes under the approval and guidelines of the regional council of Hearing Research Institute Tubingen...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28506427/italy-introduces-pre-and-post-operation-monitoring-phases-for-offshore-seismic-exploration-activities
#17
C Fossati, B Mussi, R Tizzi, G Pavan, D S Pace
Concern is growing that marine fauna can be affected by noise such as naval sonar, pile driving or geophysical surveys, among others. Literature reports a variety of animal reactions to human noise (from apparently null or negligible to strong). However, conclusive results on its effects on marine mammals at individual and population level are still lacking. In 2015, the Italian Environmental Impact Assessment Commission mandated seismic operators apply a standard scientific protocol comparing marine mammal presence before, during, and after offshore seismic survey...
May 12, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28494506/minimal-residual-disease-eradication-with-epigenetic-therapy-in-core-binding-factor-acute-myeloid-leukemia
#18
Brittany Knick Ragon, Naval Daver, Guillermo Garcia-Manero, Farhad Ravandi, Jorge Cortes, Tapan Kadia, Betul Oran, Maro Ohanian, Alessandra Ferrajoli, Naveen Pemmaraju, Hagop M Kantarjian, Gautam Borthakur
Recurrent translocations, t(8;21) or inv(16), in core binding factor acute myeloid leukemia (CBF-AML) are amenable to monitoring for minimal residual disease (MRD) with reverse transcriptase polymerase chain reaction (RTPCR). Despite a favorable prognosis, disease relapse remains the single cause of treatment failure in CBF-AML. Fusion products of these translocations recruit epigenetic silencing complexes resulting in hematopoietic maturation arrest. We hypothesized that maintenance therapy with hypomethylating agents (HMA), including decitabine (DAC) and azacitidine (AZA) after induction/consolidation, can be used for MRD elimination to ultimately prolong relapse free survival...
May 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28493791/recurrent-shoulder-instability-in-a-young-active-military-population-and-its-professional-implications
#19
James H Flint, Adam Pickett, Brett D Owens, Steven J Svoboda, Karen Y Peck, Kenneth L Cameron, John Biery, Jeffrey Giuliani, John-Paul Rue
BACKGROUND: Shoulder instability is a topic of significant interest within the sports medicine literature, particularly regarding recurrence rates and the ideal treatment indications and techniques. Little has been published specifically addressing the occupational implications of symptomatic recurrent shoulder instability. HYPOTHESIS: Previous arthroscopic repair will continue to be a significant predisposing factor for recurrent instability in a young, active population, and that recurrent instability may have a negative effect on college graduation and postgraduate occupational selection...
May 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28472923/risk-of-re-attempts-and-suicide-death-after-a-suicide-attempt-a-survival-analysis
#20
Isabel Parra-Uribe, Hilario Blasco-Fontecilla, Gemma Garcia-Parés, Luis Martínez-Naval, Oliver Valero-Coppin, Annabel Cebrià-Meca, Maria A Oquendo, Diego Palao-Vidal
BACKGROUND: Suicide is the primary cause of unnatural death in Spain, and suicide re-attempts a major economic burden worldwide. The risk factors for re-attempt and suicide after an index suicide attempt are different. This study aims to investigate risk factors for re-attempt and suicide after an index suicide attempt. METHODS: This observational study is part of a one-year telephone management program. We included all first-time suicide attempters evaluated in the emergency department at Parc Taulí-University Hospital (n = 1241) recruited over a five-year period (January 2008 to December 2012)...
May 4, 2017: BMC Psychiatry
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