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https://www.readbyqxmd.com/read/29688801/genomic-characterization-of-nonclonal-mcr-1-positive-multidrug-resistant-klebsiella-pneumoniae-from-clinical-samples-in-thailand
#1
Apichai Srijan, Katie R Margulieux, Sirigade Ruekit, Erik Snesrud, Rosslyn Maybank, Oralak Serichantalergs, Rosarin Kormanee, Prawet Sukhchat, Jossin Sriyabhaya, Mary Hinkle, John M Crawford, Patrick McGann, Brett E Swierczewski
Multidrug-resistant Klebsiella pneumoniae strains are one of the most prevalent causes of nosocomial infections and pose an increasingly dangerous public health threat. The lack of remaining treatment options has resulted in the utilization of older drug classes, including colistin. As a drug of last resort, the discovery of plasmid-mediated colistin resistance by mcr-1 denotes the potential development of pandrug-resistant bacterial pathogens. To address the emergence of the mcr-1 gene, 118 gram-negative Enterobacteriaceae isolated from clinical samples collected at Queen Sirikit Naval Hospital in Chonburi, Thailand were screened for colistin resistance using automated antimicrobial susceptibility testing and conventional PCR screening...
April 24, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29679228/recovery-time-after-oral-and-maxillofacial-ambulatory-surgery-with-dexmedetomidine-an-observational-study
#2
Belen Hernando, Antonio Martinez-Simon, Elena Cacho-Asenjo, Iñaki F Troconiz, Cristina Honorato-Cia, Alfredo Panadero, Luis L Naval, Jorge M Nuñez-Cordoba
OBJECTIVES: To evaluate the relationship between pharmacokinetic descriptors of dexmedetomidine (predicted area under the curve during the procedure, predicted plasma level at the end of the procedure, and duration of procedure) and sedation depth (proportion of time with bispectral index < 85 during the procedure) with recovery time after ambulatory procedures. MATERIALS AND METHODS: Clinical observational study of patients undergoing oral and maxillofacial ambulatory surgery with dexmedetomidine as sole sedative agent...
April 20, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29660836/final-results-of-a-phase-2-open-label-study-of-indisulam-idarubicin-and-cytarabine-in-patients-with-relapsed-or-refractory-acute-myeloid-leukemia-and-high-risk-myelodysplastic-syndrome
#3
Rita Assi, Hagop M Kantarjian, Tapan M Kadia, Naveen Pemmaraju, Elias Jabbour, Nitin Jain, Naval Daver, Zeev Estrov, Taisuke Uehara, Takashi Owa, Jorge E Cortes, Gautam Borthakur
BACKGROUND: Indisulam possesses anticancer properties through down-regulation of various cell-cycle checkpoint molecules, thereby blocking the phosphorylation of retinoblastoma protein and inducing p53 and p21. Indisulam exhibits synergy with nucleoside analogs and topoisomerase inhibitors. METHODS: The authors designed a phase 2 study of indisulam in combination with idarubicin and cytarabine in patients who had relapsed/refractory acute myeloid leukemia AML and high-risk myelodysplastic syndrome...
April 16, 2018: Cancer
https://www.readbyqxmd.com/read/29655803/role-of-msc-derived-galectin-3-in-the-aml-microenvironment
#4
Peter P Ruvolo, Vivian R Ruvolo, Jared K Burks, YiHua Qiu, Rui-Yu Wang, Elizabeth J Shpall, Leonardo Mirandola, Numsen Hail, Zhihong Zeng, Teresa McQueen, Naval Daver, Sean M Post, Maurizio Chiriva-Internati, Steven M Kornblau, Michael Andreeff
In acute myeloid leukemia (AML), high Galectin 3 (LGALS3) expression is associated with poor prognosis. The role of LGALS3 derived from mesenchymal stromal cells (MSC) in the AML microenvironment is unclear; however, we have recently found high LGALS3 expression in MSC derived from AML patients is associated with relapse. In this study, we used reverse phase protein analysis (RPPA) to correlate LGALS3 expression in AML MSC with 119 other proteins including variants of these proteins such as phosphorylated forms or cleaved forms to identify biologically relevant pathways...
April 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29649533/chitosan-nanoparticles-as-a-biocompatible-and-efficient-nanowagon-for-benzyl-isothiocyanate
#5
Shivani Uppal, Khushwinder Kaur, Rajendra Kumar, Naval Deep Kaur, Geeta Shukla, S K Mehta
A plethora of evidences support the health benefits of a sulfur containing compound called Benzyl Isothiocyanate. However, its therapeutic application is limited due to its low solubility, poor stability and inadequate bioavailability. The problem has been worked upon and resolved by the synthesis of biodegradable nanoparticles using chitosan as the controlled delivery nanowagon. The prepared nanoparticles have been characterized using UV-visible absorption spectroscopy, IR spectroscopy, XRD, TGA, TEM and FE-SEM...
April 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29645075/results-of-second-salvage-therapy-in-673-adults-with-acute-myelogenous-leukemia-treated-at-a-single-institution-since-2000
#6
Hagop M Kantarjian, Courtney D DiNardo, Graciela M Nogueras-Gonzalez, Tapan M Kadia, Elias Jabbour, Carlos E Bueso-Ramos, Susan M O'Brien, Marina Konopleva, Nitin B Jain, Naval G Daver, Elizabeth J Shpall, Richard E Champlin, Aron Simkins, Guillermo Garcia-Manero, Michael J Keating, Xuelin Huang, Jorge E Cortes, Sherry A Pierce, Farhad Ravandi, Emil J Freireich
BACKGROUND: The prognosis is poor for patients who have relapsed-refractory acute myelogenous leukemia (AML). Most published reports analyzed results from therapies in first-salvage AML or in studies that were conducted before 2000. Several novel agents and strategies are being tested for potential approval as treatment for patients with relapsed-refractory AML in second salvage. Therefore, it is important to establish the historic results of anti-AML therapies in this setting in the modern era...
April 12, 2018: Cancer
https://www.readbyqxmd.com/read/29626145/risk-factors-for-lower-limb-injuries-during-initial-naval-training-a-prospective-study
#7
Daniel R Bonanno, S E Munteanu, G S Murley, K B Landorf, H B Menz
INTRODUCTION: This study aimed to identify risk factors associated with the development of common lower limb injuries during initial defence training in naval recruits who were enrolled in a randomised trial. METHODS: Three-hundred and six naval recruits were randomly allocated flat insoles (n=153) or foot orthoses (n=153) while undertaking 11 weeks of initial training. Participant characteristics (including anthropometrics, general health, physical activity, fitness and foot characteristics) were collected at the baseline assessment and injuries were documented prospectively...
April 6, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29618750/evolution-of-sex-determination-loci-in-atlantic-salmon
#8
James Kijas, Sean McWilliam, Marina Naval Sanchez, Peter Kube, Harry King, Bradley Evans, Torfinn Nome, Sigbjørn Lien, Klara Verbyla
Teleost fish exhibit a remarkable diversity in the control of sex determination, offering the opportunity to identify novel differentiation mechanisms and their ecological consequences. Here, we perform GWAS using 4715 fish and 46,501 SNP to map sex determination to three separate genomic locations in Atlantic salmon (Salmo salar). To characterize each, whole genome sequencing was performed to 30-fold depth of coverage using 20 fish representing each of three identified sex lineages. SNP polymorphism reveals male fish carry a single copy of the male specific region, consistent with an XX/XY or male heterogametric sex system...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29618048/mammalian-genomic-regulatory-regions-predicted-by-utilizing-human-genomics-transcriptomics-and-epigenetics-data
#9
Quan H Nguyen, Ross L Tellam, Marina Naval-Sanchez, Laercio R Porto-Neto, William Barendse, Antonio Reverter, Benjamin Hayes, James Kijas, Brian P Dalrymple
Genome sequences for hundreds of mammalian species are available, but an understanding of their genomic regulatory regions, which control gene expression, is only beginning. A comprehensive prediction of potential active regulatory regions is necessary to functionally study the roles of the majority of genomic variants in evolution, domestication, and animal production. We developed a computational method to predict regulatory DNA sequences (promoters, enhancers, and transcription factor binding sites) in production animals (cows and pigs) and extended its broad applicability to other mammals...
March 1, 2018: GigaScience
https://www.readbyqxmd.com/read/29617268/antidiabetic-and-renoprotective-effect-of-anogeissus-acuminata-leaf-extract-on-experimentally-induced-diabetic-nephropathy
#10
Archana M Navale, Archana Paranjape
BACKGROUND: Diabetic nephropathy is the leading cause of end-stage renal disease. Hyperglycemia, oxidative stress, and inflammation are some of the mechanisms involved in renal damage. Anogeissus acuminata (AA) is used in India as an antidiabetic agent and has potent antioxidant activity. However, it has never been evaluated for its effect on diabetic nephropathy. Hence, in the present study we aimed to evaluate its effect on streptozotocin-induced diabetes mellitus and its renal complications...
April 4, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29589477/drug-repositioning-for-novel-antitrichomonas-from-known-antiprotozoan-drugs-using-hierarchical-screening
#11
Alfredo Meneses-Marcel, Yovani Marrero-Ponce, Alexandra Ibáñez-Escribano, Alicia Gómez-Barrio, José A Escario, Stephen J Barigye, Enrique Terán, Cesar R García-Jacas, Yanetsy Machado-Tugores, Juan J Nogal-Ruiz, Vicente J Arán-Redó
AIM: Metronidazole is the most widely used drug in trichomoniasis therapy. However, the emergence of metronidazole-resistant Trichomonas vaginalis isolates calls for the search for new drugs to counter the pathogenicity of these parasites. RESULTS: Classification models for predicting the antitrichomonas activity of molecules were built. These models were employed to screen antiprotozoal drugs, from which 20 were classified as active. The in vitro experiments showed moderate to high activity for 19 of the molecules at 10 μg/ml, while 3 compounds yielded higher activity than the reference at 1 μg/ml...
March 28, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29584667/computationally-efficient-automatic-coast-mode-target-tracking-based-on-occlusion-awareness-in-infrared-images
#12
Sohyun Kim, Gwang-Il Jang, Sungho Kim, Junmo Kim
This paper proposes the automatic coast mode tracking of centroid trackers for infrared images to overcome the target occlusion status. The centroid tracking method, using only the brightness information of an image, is still widely used in infrared imaging tracking systems because it is difficult to extract meaningful features from infrared images. However, centroid trackers are likely to lose the track because they are highly vulnerable to screened status by the clutter or background. Coast mode, one of the tracking modes, maintains the servo slew rate with the tracking rate right before the loss of track...
March 27, 2018: Sensors
https://www.readbyqxmd.com/read/29584497/initial-analysis-of-archived-non-human-primate-frontal-and-rear-impact-data-from-the-biodynamics-data-resource
#13
Ardyn V Olszko, Christine M Beltran, Kimberly B Vasquez, James S McGhee, Valeta C Chancey, Narayan Yoganandan, Frank A Pintar, Jamie L Baisden
OBJECTIVE: The research objective was to conduct an initial analysis of non-human primate (NHP) data from frontal and rear impact events archived in the Biodynamics Data Resource (BDR) records of the Naval Biodynamics Laboratory (NBDL). These rare data, collected between 1973 and 1989, will inform the safety community of upper-end tolerance limits of NHP and may be related to severe crash scenarios. METHODS: Data from frontal and rear acceleration tests to 93 macaque NHP were examined...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29578903/acceptance-testing-of-thermoluminescent-dosimeter-holders
#14
Alexander Romanyukha, Matthew D Grypp, Thad J Sharp, John N DiRito, Martin E Nelson, Stanley T Mavrogianis, Jeancarlo Torres, Luis A Benevides
The U.S. Navy uses the Harshaw 8840/8841 dosimetric (DT-702/PD) system, which employs LiF:Mg,Cu,P thermoluminescent dosimeters (TLDs), developed and produced by Thermo Fisher Scientific (TFS). The dosimeter consists of four LiF:Mg,Cu,P elements, mounted in Teflon® on an aluminum card and placed in a plastic holder. The holder contains a unique filter for each chip made of copper, acrylonitrile butadiene styrene (ABS), Mylar®, and tin. For accredited dosimetry labs, the ISO/IEC 17025:2005(E) requires an acceptance procedure for all new equipment...
May 2018: Health Physics
https://www.readbyqxmd.com/read/29575586/correlation-between-observation-task-performance-and-visual-acuity-contrast-sensitivity-and-environmental-light-in-a-simulated-maritime-study
#15
Vilhelm F Koefoed, Jörg Assmuss, Gunnar Høvding
PURPOSE: To examine the relevance of visual acuity (VA) and index of contrast sensitivity (ICS) as predictors for visual observation task performance in a maritime environment. METHODS: Sixty naval cadets were recruited to a study on observation tasks in a simulated maritime environment under three different light settings. Their ICS were computed based on contrast sensitivity (CS) data recorded by Optec 6500 and CSV-1000E CS tests. The correlation between object identification distance and VA/ICS was examined by stepwise linear regression...
March 25, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29574878/effect-of-emergency-physician-performed-point-of-care-ultrasound-and-radiology-department-performed-ultrasound-examinations-on-the-emergency-department-length-of-stay-among-pregnant-women-at-less-than-20-weeks-gestation
#16
Brian B Morgan, Amanda Kao, Stacy A Trent, Nicole Hurst, Lauren Oliveira, Andrea L Austin, John L Kendall
OBJECTIVES: We sought to confirm retrospective studies that measured an approximately 20% reduction in emergency department (ED) length of stay (LOS) in early-gestation pregnant women who receive emergency physician-performed point-of-care ultrasound (US) examinations rather than radiology department-performed US examinations for evaluation of intrauterine pregnancy (IUP). METHODS: A randomized controlled clinical trial was performed at an urban academic safety net hospital and 2 Naval medical centers in the United States...
March 25, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29567885/applicability-of-2008-world-health-organization-classification-system-of-hematolymphoid-neoplasms-learning-experiences
#17
Sushil Modkharkar, Pooja Navale, Pratibha Kadam Amare, Anuradha Chougule, Nikhil Patkar, Prashant Tembhare, Hari Menon, Manju Sengar, Navin Khattry, Shripad Banavali, Brijesh Arora, Gaurav Narula, Siddhartha Laskar, Nehal Khanna, Mary Ann Muckaden, Venkatesh Rangarajan, Archi Agrawal, Tanuja Shet, Sridhar Epari, P G Subramanian, Sumeet Gujral
Background: 2008 World Health Organization (WHO) classification of hematolymphoid neoplasms (HLN) has classified them based on morphology, results of various ancillary techniques, and clinical features.[1] There are no studies looking at the applicability of WHO classification. Aims: The aim of the study was to calculate proportions of all HLN subtypes seen during 1-year period based on 2008 WHO classification of HLN and study applicability and also shortcomings of practices in a tertiary care center in India...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29564255/prospective-study-on-prevalence-of-anemia-of-pregnant-women-and-its-outcome-a-community-based-study
#18
Ravishankar Suryanarayana, Muninarayana Chandrappa, Anil Navale Santhuram, S Prathima, S R Sheela
Background: Anemia is one of the most common nutritional deficiency disorders affecting the pregnant women in the developing countries. Anemia during pregnancy is commonly associated with poor pregnancy outcome and can result in complications that threaten the life of both mother and fetus. Objective: The objective of the study was to estimate the prevalence of anemia among pregnant women and to determine its association with maternal and fetal outcomes. Settings and Design: This study design was a prospective, observational, community-based study...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29562971/the-persistent-issue-of-simulator-sickness-in-naval-aviation-training
#19
Daniel J Geyer, Adam T Biggs
Virtual simulations offer nearly unlimited training potential for naval aviation due to the wide array of scenarios that can be simulated in a safe, reliable, and cost-effective environment. This versatility has created substantial interest in using existing and emerging virtual technology to enhance training scenarios. However, the virtual simulations themselves may hinder training initiatives by inducing simulator sickness among the trainees, which is a series of symptoms similar to motion sickness that can arise from simulator use...
April 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29553010/-cleanse-or-die-british-naval-hygiene-in-the-age-of-steam-1840-1900
#20
Elise Juzda Smith
This article focuses on the consolidation of naval hygiene practices during the Victorian era, a period of profound medical change that coincided with the fleet's transition from sail to steam. The ironclads of the mid- to late- nineteenth century offered ample opportunities to improve preventive medicine at sea, and surgeons capitalised on new steam technologies to provide cleaner, dryer, and airier surroundings below decks. Such efforts reflected the sanitarian idealism of naval medicine in this period, inherited from the eighteenth-century pioneers of the discipline...
April 2018: Medical History
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