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https://www.readbyqxmd.com/read/29047619/high-power-lasers-for-directed-energy-applications-reply
#1
P Sprangle, B Hafizi, A Ting, R P Fischer, C C Davis, W Nelson
The comment by Vorontsov and Weyrauch [Appl. Opt.55, 9950 (2016)APOPAI0003-693510.1364/AO.55.009950] is aimed at rebutting the critiques in Sprangle et al. [Appl. Opt.54, F201 (2015)APOPAI0003-693510.1364/AO.54.00F201] and Nelson et al. [Appl. Opt.55, 1757 (2016)APOPAI0003-693510.1364/AO.55.001757]. In the comment, Vorontsov and colleagues describe their experiments aimed at demonstrating the feasibility of coherent combining of lasers on a distant target, using relatively low-power lasers and a cooperative retro-reflective target...
June 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047158/hyper-cvad-plus-nelarabine-in-newly-diagnosed-adult-t-cell-acute-lymphoblastic-leukemia-and-t-lymphoblastic-lymphoma
#2
Yasmin Abaza, Hagop M Kantarjian, Stefan Faderl, Elias Jabbour, Nitin Jain, Deborah Thomas, Tapan Kadia, Gautam Borthakur, Joseph D Khoury, Jan Burger, William Wierda, Susan O'Brien, Marina Konopleva, Alessandra Ferrajoli, Partow Kebriaei, Bouthaina Dabaja, Steven Kornblau, Yesid Alvarado, Naval Daver, Naveen Pemmaraju, Prithviraj Bose, Philip Thompson, Hind Al Azzawi, Mary Kelly, Rebecca Garris, Preetesh Jain, Guillermo Garcia-Manero, Jorge Cortes, Farhad Ravandi
Nelarabine, a water soluble prodrug of 9-β-D-arabinofuranosylguanine (ara-G), is a T-cell specific purine nucleoside analogue. Given its activity in relapsed and refractory T acute lymphoblastic leukemia (T-ALL) and T lymphoblastic lymphoma (T-LBL), we sought to define its role in the frontline treatment of adult patients. Therefore, we conducted a single arm phase 2 study to determine the safety and efficacy of nelarabine in combination with hyper-CVAD in newly diagnosed patients. For induction/consolidation, patients received eight cycles of hyper-CVAD alternating with high-dose methotrexate and cytarabine plus two cycles of nelarabine given at a dose of 650 mg/m(2) intravenously daily for 5 days...
October 19, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29036862/naval-special-warfare-nsw-crewmen-demonstrate-diminished-cervical-strength-and-range-of-motion-compared-to-nsw-students
#3
Shawn R Eagle, Takashi Nagai, Paul Morgan, Renee Hendershot, Timothy C Sell
BACKGROUND: Cumulative effects of high-impact vertical forces, like those experienced on an open-ocean mission, could be an injury concern for the cervical spine. OBJECTIVE: Compare cervical range of motion (ROM) and strength measures between students and NSW Crewmen and secondarily to compare these measures between students and Crewmen separated into three groups based on years of service. METHODS: A volunteer sample of 186 students (age: 22...
October 9, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29027261/prognostic-significance-of-additional-chromosomal-abnormalities-at-the-time-of-diagnosis-in-patients-with-chronic-myeloid-leukemia-treated-with-frontline-tyrosine-kinase-inhibitors
#4
Ahmad Alhuraiji, Hagop Kantarjian, Prajwal Boddu, Farhad Ravandi, Gautam Borthakur, Courtney DiNardo, Naval Daver, Tapan Kadia, Naveen Pemmaraju, Sherry Pierce, Guillermo Garcia-Manero, William Wierda, Srdan Verstovsek, Elias Jabbour, Jorge Cortes
Additional cytogenetic abnormalities (ACA) are considered a high risk feature in chronic myeloid leukemia (CML). However, its prognostic significance at the time of diagnosis in the setting of new tyrosine kinase inhibitors (TKIs) is less well understood. Patients with CML in CP with or without ACA at diagnosis treated with frontline TKIs in prospective clinical trials were analyzed for outcomes. Among 603 patients treated, 29 (5%) had ACA. Patients with ACA included 2 of 72 (2.8%) treated with imatinib 400 mg, 9 of 207 (4...
October 13, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29026061/from-specific-humidifier-disinfectants-disease-to-humidifier-disinfectants-syndrome
#5
Jong-Han Leem, Jong-Hyeon Lee
Humidifier disinfectant damage was terrible chemical damage caused by household goods that happened in only South Korea, but it is still very little known in humidifier disinfectant damage. Up to now, previous research tried to focus on interstitial fibrosis on terminal bronchiole and alveoli because it is specific finding, compared with other diseases. To figure out overall effects from HDs, many epidemiologic and toxicologic research is underway. Humidifier disinfectants showed to give rise to typical toxicologic effects on various target organs, such as skin, conjunctiva, naval mucosa, bronchial mucosa, alveoli and so on, which were sharing common toxicological responses...
October 7, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28974980/effects-of-hydroalcoholic-extract-of-rhus-coriaria-seed-on-glucose-and-insulin-related-biomarkers-lipid-profile-and-hepatic-enzymes-in-nicotinamide-streptozotocin-induced-type-ii-diabetic-male-mice
#6
Akram Ahangarpour, Hamid Heidari, Majid Salehizade Junghani, Reza Absari, Mehdi Khoogar, Ehsan Ghaedi
Type 2 diabetes often leads to dislipidemia and abnormal activity of hepatic enzymes. The purpose of this study was to evaluate the antidiabetic and hypolipidemic properties of Rhus coriaria (R. coriaria) seed extrac on nicotinamide-streptozotocin induced type 2 diabetic mice. In this experimental study, 56 male Naval Medical Research Institute mice (30-35 g) were randomly separated into seven groups: control, diabetic group, diabetic mice treated with glibenclamide (0.25 mg/kg, as standard antidiabetic drug) or R...
October 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28972430/life-after-ponatinib-failure-outcomes-of-chronic-and-accelerated-phase-cml-patients-who-discontinued-ponatinib-in-the-salvage-setting
#7
Prajwal Boddu, Abdul Rashid Shah, Gautam Borthakur, Srdan Verstovsek, Guillermo Garcia-Manero, Naval Daver, Tapan Kadia, Farhad Ravandi, Nitin Jain, Ahmad Alhuraiji, Jan Burger, Steven Kornblau, Sherry Pierce, Sara Dellasala, Elias Jabbour, Hagop Kantarjian, Jorge Cortes
Ponatinib is a pan-tyrosine kinase inhibitor (TKI) with efficacy in multirefractory CML patients who have failed other TKIs. Despite excellent response rates, resistance or intolerance may develop. We conducted a retrospective review of the outcome of patients with chronic (CP) and accelerated (AP) phase CML refractory to prior TKI who discontinued ponatinib for resistance or intolerance. Nineteen CP patients, discontinued due to resistance (n = 13), toxicity (n = 5) and to pursue stem cell transplantation (n = 1)...
October 3, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28958191/pet-ct-in-aml-related-hemophagocytic-lymphohistiocytosis
#8
Prajwal Boddu, Sergio Pina Oviedo, Caitlin R Rausch, Clinton Yam, Naval Daver, Hagop Kantarjian, Tapan M Kadia
No abstract text is available yet for this article.
September 28, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28952659/the-effect-of-hardiness-on-symptoms-of-insomnia-during-a-naval-mission
#9
Morten Nordmo, Sigurd William Hystad, Sverre Sanden, Bjørn Helge Johnsen
BACKGROUND: Sleep is increasingly being recognised as important for the health and well-being of sailors. The aim of the current study is to investigate the relationship between hardiness and reported insomnia-symptoms in a maritime military setting during a 4-month counter piracy naval mission in the Gulf of Aden. MATERIALS AND METHODS: A sample of 281 officers, sailors, and enlisted personnel were measured on levels of hardiness before the mission. The participants were split into low and high hardiness groups based on the group level mean...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28947461/the-association-between-submarine-service-and-multimorbidity-a-cross-sectional-study-of-korean-naval-personnel
#10
Jihun Kang, Yun-Mi Song
OBJECTIVE: We aimed to estimate the prevalence of multimorbidity (≥2 chronic health problems) among Korean submariners and to evaluate the association between submarine service and multimorbidity and disease burden. STUDY DESIGN AND SETTING: This cross-sectional study included 590 naval personnel who visited a Korean primary care clinic during 2014-2015. Data regarding general characteristics and morbidities were collected from medical records, and disease burden was assessed using the Cumulative Illness Rating Scale (CIRS)...
September 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28943193/epidemiology-of-musculoskeletal-injuries-sustained-by-naval-special-forces-operators-and-students
#11
Mita Lovalekar, Katherine A Perlsweig, Karen A Keenan, Thomas M Baldwin, Michael Caviston, Anne E McCarthy, Jeffrey J Parr, Bradley C Nindl, Kim Beals
OBJECTIVES: The aim of this analysis was to describe the incidence and common types of medical chart-reviewed musculoskeletal injuries, among four distinct groups of Naval Special Warfare (NSW) personnel: Sea, Air, and Land (SEAL) Operators, SEAL Qualification Training (SQT) students, Special Warfare Combatant-craft Crewman (SWCC) Operators, and Crewman Qualification Training (CQT) students. DESIGN: Descriptive cross-sectional study. METHODS: Medical records were reviewed for 920 NSW personnel...
September 9, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28928303/vitamin-d-status-of-adult-females-residing-in-ballabgarh-health-and-demographic-surveillance-system-a-community-based-study
#12
Puneet Misra, Rahul Srivastava, Anoop Misra, Shashi Kant, Priyanka Kardam, Naval K Vikram
BACKGROUND: Vitamin D deficiency (VDD) is widespread, yet it is the most underdiagnosed and undertreated nutritional deficiency in the world. The prevalence of VDD is estimated to affect over 1 billion people worldwide. OBJECTIVES: The present study was conducted to estimate the prevalence of VDD among adult females aged 20-60 years residing in a rural community of North India, and to find its association with various sociobehavioral risk factors. METHODS: The present study is an analytical cross-sectional study conducted among females aged 20-60 years in rural Ballabgarh...
July 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28927784/safety-and-efficacy-of-blinatumomab-in-combination-with-a-tyrosine-kinase-inhibitor-for-the-treatment-of-relapsed-philadelphia-chromosome-positive-leukemia
#13
Rita Assi, Hagop Kantarjian, Nicholas J Short, Naval Daver, Koichi Takahashi, Guillermo Garcia-Manero, Courtney DiNardo, Jan Burger, Jorge Cortes, Nitin Jain, William Wierda, Salim Chamoun, Marina Konopleva, Elias Jabbour
OBJECTIVE: The treatment of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia has been revolutionized with the introduction of tyrosine kinase inhibitors (TKIs) and the combination of these agents with chemotherapy. Blinatumomab is a bispecific anti-CD3/CD19 monoclonal antibody with clinical activity as single-agent in the relapsed setting and independent of BCR-ABL1 mutational status, including T315I. The combination of blinatumomab with a TKI may further improve outcomes for this high-risk population, including higher eradication of minimal residual disease and minimize the use of chemotherapy...
August 18, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28926144/characterization-of-tp53-mutations-in-low-grade-myelodysplastic-syndromes-and-myelodysplastic-syndromes-with-a-non-complex-karyotype
#14
Wei Wang, Mark J Routbort, Zhenya Tang, Chi Young Ok, Keyur P Patel, Naval Daver, Guillermo Garcia-Manero, L Jeffrey Medeiros, Sa A Wang
OBJECTIVES: Although commonly associated with high-grade myelodysplastic syndrome (MDS) and MDS with a complex karyotype, TP53 mutations also occur in low-grade MDS and MDS with a non-complex karyotype. In latter cases, their clinicopathological features and the characteristics of TP53 mutations remain poorly characterized. METHODS: 176 MDS cases with TP53 mutations were stratified and characterized based on their karyotype and histologic subtype. RESULTS: Among 176 cases, 17% had a non-complex karyotype and 24% were low-grade MDS...
September 19, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28925994/chimeric-antigen-receptor-t-cell-therapy-assessment-and-management-of-toxicities
#15
REVIEW
Sattva S Neelapu, Sudhakar Tummala, Partow Kebriaei, William Wierda, Cristina Gutierrez, Frederick L Locke, Krishna V Komanduri, Yi Lin, Nitin Jain, Naval Daver, Jason Westin, Alison M Gulbis, Monica E Loghin, John F de Groot, Sherry Adkins, Suzanne E Davis, Katayoun Rezvani, Patrick Hwu, Elizabeth J Shpall
Immunotherapy using T cells genetically engineered to express a chimeric antigen receptor (CAR) is rapidly emerging as a promising new treatment for haematological and non-haematological malignancies. CAR-T-cell therapy can induce rapid and durable clinical responses, but is associated with unique acute toxicities, which can be severe or even fatal. Cytokine-release syndrome (CRS), the most commonly observed toxicity, can range in severity from low-grade constitutional symptoms to a high-grade syndrome associated with life-threatening multiorgan dysfunction; rarely, severe CRS can evolve into fulminant haemophagocytic lymphohistiocytosis (HLH)...
September 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28922799/restoring-victory-naval-heritage-identity-and-memory-in-interwar-britain
#16
Don Leggett
In the decade following 1918, HMS Victory was restored as a memorial to the nation, empire, the Navy, and all the sailors who had lost their lives in the Great War. This piece of Britain's naval heritage became a focal point for Great War memory and a resource for narrating the Navy's place in post-war Britain. This article analyses the restoration campaign, focusing on its appeal work and the materials it produced, discourses surrounding the restoration and the use of Victory's oak to recover this ship's importance at the intersection between Britain and its Navy in the aftermath of the Great War, and the function that the Navy played in the construction of post-war memory and identity...
March 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28919698/skeletal-lead-burden-of-the-british-royal-navy-in-colonial-antigua
#17
K L Giffin, T Swanston, I Coulthard, A R Murphy, D M L Cooper, T L Varney
Lead (Pb) has been known to be a cause of human poisoning since ancient times, but despite this, it was a widely used metal in the European colonial period. In this study, the relationship between Pb exposure and the demographic variables ancestry and age was explored by comparing the bone Pb levels of individuals that were of either African or European ancestry, excavated from a British Royal Navy hospital cemetery (1793-1822 CE) at English Harbour in Antigua, West Indies. More direct comparisons of Pb levels between the two ancestral groups were possible in this study because of the unsegregated nature of this cemetery...
July 2017: Int J Osteoarchaeol
https://www.readbyqxmd.com/read/28918304/haploidentical-transplantation-for-older-patients-with-acute-myeloid-leukemia-and-myelodysplastic-syndrome
#18
Stefan O Ciurea, Mithun V Shah, Rima M Saliba, Sameh Gaballa, Piyanuch Kongtim, Gabriela Rondon, Julianne Chen, Whitney Wallis, Kai Cao, Marina Konopleva, Naval Daver, Jorge Cortes, Farhad Ravandi, Amin Alousi, Sairah Ahmed, Uday Popat, Simrit Parmar, Qaiser Bashir, Oran Betul, Chitra Hosing, Elizabeth J Shpall, Katayoun Rezvani, Issa F Khouri, Partow Kebriaei, Richard E Champlin
Allogeneic stem cell transplantation with HLA-matched donors is increasingly used for older patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). It remains unclear if haploidentical stem cell transplantation (haploSCT) is a suitable option for older patients with this disease. We analyzed 43 patients with AML/MDS (median age, 61 years) who underwent a haploSCT at our institution. All patients received a fludarabine-melphalan-based reduced-intensity conditioning regimen and post-transplant cyclophosphamide-based graft-versus-host disease (GVHD) prophylaxis...
September 14, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28890141/-gait-speed-and-the-appearance-of-neurocognitive-disorders-in-older-adults-results-of-a-peruvian-cohort
#19
José F Parodi, Wendy Nieto-Gutierrez, Walter A Tellez, Iris Ventocilla-Gonzales, Fernando M Runzer-Colmenares, Alvaro Taype-Rondan
INTRODUCTION: The prevention and management of neurocognitive disorders (NCD) among older adults can be improved by early identification of risk factors such as walking speed. The objective of the study is to assess the association between gait speed and NCD onset in a population of Peruvian older adults. MATERIAL AND METHODS: Cohort conducted in older adults who attended the geriatrics service of Naval Medical Center (Callao, Peru). During the baseline assessment, participants' gait speed was recorded...
September 7, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28885945/effect-of-novel-continuing-medical-education-curriculum-on-attitudes-and-understanding-of-primary-care-medicine-for-the-naval-surface-provider
#20
Joseph LaGrew, Cameron Hightower, Terrie Vasilopoulos
INTRODUCTION: Naval Surface Forces provide care in austere environments with unique facility, personnel, and material limitations that can put the patient at risk without proper consideration of these circumstances. Tailored shipboard education currently exists but is greatly dependent on the time, preferences, expertise, and ability of a single teaching officer, allowing for significant variability in the level of training. MATERIALS AND METHODS: One hundred and twenty-two individuals were trained in 19 topics presented over 12 months through the Naval Surface Forces Pacific Command Medical Readiness Division to all surface providers on Naval Base San Diego...
September 2017: Military Medicine
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