Jun Wang, Yuting Yan, Wenjie Xiong, Ge Song, Yi Wang, Jiawei Zhao, Yujiao Jia, Chengwen Li, Zhen Yu, Ying Yu, Jiawen Chen, Yang Jiao, Tingyu Wang, Rui Lyu, Qinghua Li, Yueshen Ma, Wei Liu, Dehui Zou, Gang An, Qi Sun, Huijun Wang, Zhijian Xiao, Jianxiang Wang, Lugui Qiu, Shuhua Yi
Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) is a heterogeneous disease in which the role of immunoglobulin heavy chain genes (IGH) remains unknown. To determine the clinical relevance of the IGH repertoire in LPL/WM patients, we performed immunoglobulin gene rearrangement and complementarity determining region 3 (CDR3) analysis. The IGH variable gene repertoire was remarkably biased in LPL/WM. IGHV3-23, IGHV4-34, IGHV3-30, IGHV3-7, and IGHV3-74 accounted for half of the cohorts' repertoire...
May 10, 2022: Blood Advances