keyword
MENU ▼
Read by QxMD icon Read
search

traumatic spinal cord injury

keyword
https://www.readbyqxmd.com/read/27931169/a-mouse-model-of-bilateral-cervical-contusion-compression-spinal-cord-injury
#1
Nicole Forgione, Mahmood Chamankhah, Michael Fehlings
Cervical spinal cord injury (cSCI) occurs in over half of all cases of traumatic SCI, yet we lack therapies that can generate significant functional recovery in these patients. The development of animal models of cSCI will aid in the pre-clinical assessment of therapies and in understanding basic pathophysiological mechanisms. Here we describe a clinically relevant model of cervical contusion-compression injury in the mouse. Using a modified aneurism clip we generated a bilateral, incomplete injury that mimics contusion-compression injuries most commonly seen in humans...
December 8, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27924525/a-three-day-consecutive-fingolimod-administration-improves-neurological-functions-and-modulates-multiple-immune-responses-of-cci-mice
#2
Chuang Gao, Yu Qian, Jinhao Huang, Dong Wang, Wanqiang Su, Peng Wang, Linyue Guo, Wei Quan, Shuo An, Jianning Zhang, Rongcai Jiang
Excessive inflammation after traumatic brain injury (TBI) is a major cause of secondary TBI. Though several inflammatory biomarkers have been postulated as the risk factors of TBI, there has not been any comprehensive description of them. Fingolimod, a new kind of immunomodulatory agent which can diminish various kinds of inflammatory responses, has shown additional therapeutic effects in the treatment of intracranial cerebral hematoma (ICH), ischemia, spinal cord injury (SCI), and many other CNS disorders...
December 6, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27916623/multiple-beneficial-effects-of-melanocortin-mc4-receptor-agonists-in-experimental-neurodegenerative-disorders-therapeutic-perspectives
#3
REVIEW
Daniela Giuliani, Alessandra Ottani, Laura Neri, Davide Zaffe, Paolo Grieco, Jerzy Jochem, Gian Maria Cavallini, Anna Catania, Salvatore Guarini
Melanocortin peptides induce neuroprotection in acute and chronic experimental neurodegenerative conditions. Melanocortins likewise counteract systemic responses to brain injuries. Furthermore, they promote neurogenesis by activating critical signaling pathways. Melanocortin-induced long-lasting improvement in synaptic activity and neurological performance, including learning and memory, sensory-motor orientation and coordinated limb use, has been consistently observed in experimental models of acute and chronic neurodegeneration...
December 1, 2016: Progress in Neurobiology
https://www.readbyqxmd.com/read/27912248/mean-arterial-blood-pressure-management-of-acute-spinal-cord-injured-patients-during-the-pre-hospital-and-early-admission-period
#4
Jin Wee Tee, Farhaan Altaf, Lise M Belanger, Tamir Ailon, John Street, Scott J Paquette, Michael C Boyd, Charles G Fisher, Marcel F Dvorak, Brian K Kwon
The optimization and maintenance of mean arterial blood pressure (MAP) and the general avoidance of systemic hypotension for the first 5 to 7 days following acute traumatic SCI is considered to be important for minimizing secondary spinal cord ischemic damage. The characterization of hemodynamic parameters in the immediate post-injury stage prior to admission to a specialized spine unit has not been previously reported. Here we describe the blood pressure management of 40 acute tSCI patients in the early post-injury phases of care prior to their arrival in a specialized spinal injury high dependency unit (HDU), intensive care unit (ICU) or operating room (OR)...
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27912032/pain-input-impairs-recovery-after-spinal-cord-injury-treatment-with-lidocaine
#5
Joel D Turtle, Misty M Strain, Miriam Aceves, Yung-Jen Huang, Joshua A Reynolds, Michelle A Hook, James W Grau
More than 90% of spinal cord injuries are caused by traumatic accidents and are often associated with other tissue damage (polytrauma) that can provide a source of continued pain input during recovery. In a clinically relevant spinal cord contusion injury model, prior work has shown that noxious stimulation at an intensity that engages pain (C) fibers soon after injury augments secondary injury and impairs functional recovery. Noxious input increases the expression of pro-inflammatory cytokines (interleukin 1β and 18), cellular signals associated with cell death (caspase 3 and 8), and physiological signs of hemorrhage...
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27911071/severe-brain-injury-in-massachusetts-assessing-the-continuum-of-care
#6
Laura Lorenz, Gabrielle Katz
Acquired brain injury (ABI) is a major public health problem in Massachusetts (Hackman et al, 2014) and includes traumatic brain injury (TBI), stroke, ABI-related infectious diseases, metabolic disorders affecting the central nervous system (brain and spinal cord), and brain tumor. Advances in emergency medical care and neurosurgery mean that more people are surviving severe traumatic brain injury (Trexler et al, 2014). Yet many patients with severe TBI in particular, are not receiving inpatient services after initial treatment (Hackman et al, 2014; CDC, 2014) or later that are known to be effective (Malec & Kean, 2015; Lewis & Horn, 2015; BI Commission, 2011; Kolakowsky-Hayner et al, 2000; Interviews)...
December 10, 2015: Issue Brief
https://www.readbyqxmd.com/read/27909916/effects-of-different-fluences-of-low-level-laser-therapy-in-an-experimental-model-of-spinal-cord-injury-in-rats
#7
Suellen Veronez, Lívia Assis, Paula Del Campo, Flávia de Oliveira, Gláucia de Castro, Ana Claudia Muniz Renno, Carla Christina Medalha
The aim of this study was to evaluate the in vivo response of different fluences of low-level laser therapy (LLLT) on the area of the injury, inflammatory markers, and functional recovery using an experimental model of traumatic spinal cord injury (SCI). Thirty two rats were randomly divided into four experimental groups: control group (CG), laser-treated group 500 J/cm(2) (L-500), laser-treated group 750 J/cm(2) (L-750), and laser-treated group 1000 J/cm(2) (L-1000). SCI was performed by an impactor equipment (between the ninth and tenth thoracic vertebrae), with a pressure of 150 kdyn...
December 1, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27909623/distribution-of-interstitial-cells-of-cajal-in-the-bladders-of-fetal-rats-with-retinoic-acid-induced-myelomeningocele
#8
Ali Tekin, Osman Zeki Karakuş, Gülce Hakgüder, Oğuz Ateş, Erdener Özer, Mustafa Olguner, Feza Miraç Akgür
OBJECTIVE: Myelomeningocele (MMC) is one of the most common reason of neurogenic bladder dysfunction in children. Although neurogenic bladder dysfunction occurrence is related with bladder innervation, also there are some changes seen in the smooth muscle and neural cells of the bladder. Interstitial cells of Cajal (ICC) are the pacemaker cells found in organs with peristaltic activity. Although it has been shown that ICC are diminished in the rat urinary bladder with traumatic spinal cord injury, there is no data about ICC in fetal rat bladders with MMC...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27907962/critical-care-of-traumatic-cervical-spinal-cord-injuries-preventing-secondary-injury
#9
Gary Schwartzbauer, Deborah Stein
The incidence of traumatic spinal cord injury (SCI) has not changed much over the years due to an aging population suffering falls, yet advances have been made in quality of life and survival time. In addition to initial medical and surgical stabilization, modern intensive care unit (ICU) care throughout the critical early period following SCI is essential to avoid continued secondary injury to the spinal cord. Cervical SCI patients are particularly prone and sensitive to periods of cardiovascular instability and respiratory failure directly resulting from their injuries...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27904914/testicular-infarction-in-a-patient-with-spinal-cord-injury-with-epididymitis-a-case-report
#10
Po-Cheng Hsu, William J Huang, Shih-Fong Huang
: O-bjective: To describe a case of epididymitis-related testicular infarction in a patient with spinal cord injury. CASE REPORT: A 22-year-old man with a traumatic spinal cord injury (American Spinal Injury Association Impairment Scale A; neurological level, C4) developed epididymitis during hospitalization. He presented with spiking fever, autonomic dysreflexia, and increased spasticity. Physical examination revealed a rapidly progressive, firm swelling of the right hemiscrotum; however, the patient had no subjective complaint of pain owing to a loss of sensation...
November 30, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27898477/costs-and-length-of-stay-for-the-acute-care-of-patients-with-motor-complete-spinal-cord-injury-following-cervical-trauma-the-impact-of-early-transfer-to-specialized-acute-sci-center
#11
Andréane Richard-Denis, Debbie Ehrmann Feldman, Cynthia Thompson, Étienne Bourassa-Moreau, Jean-Marc Mac-Thiong
OBJECTIVE: Acute spinal cord injury (SCI) centers aim to optimize outcome following SCI. However, there is no timeframe to transfer patients from regional to SCI centers in order to promote cost-efficiency of acute care. Our objective was to compare costs and length of stay (LOS) following early and late transfer to the SCI center. DESIGN: A retrospective cohort study involving 116 individuals was conducted. Group 1 (n = 87) was managed in an SCI center promptly after the trauma, whereas group 2 (n = 29) was transferred to the SCI center only after surgery...
November 24, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27897187/a-latent-structural-equation-model-of-protective-behaviors-and-pressure-ulcer-outcomes-among-people-living-with-spinal-cord-injury
#12
C Li, N D DiPiro, J Krause
STUDY DESIGN: Cross-sectional. OBJECTIVE: To develop a latent structural model to demonstrate the relationship between factor structures of protective health behaviors and pressure ulcer (PrU) outcomes among participants with spinal cord injury (SCI). SETTING: Data were collected at a large specialty hospital and analyzed at a medical university in the Southeastern USA. METHODS: A total of 1871 participants with traumatic SCI of at least 1 year duration were included...
November 29, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27889959/fumaric-acid-esters-attenuate-secondary-degeneration-following-spinal-cord-injury
#13
Marika Cordaro, Giovanna Casili, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Spinal cord injury (SCI) causes permanent changes in motor, sensory and autonomic functions. Unfortunately, there are not a stable cures and current treatments include surgical decompression, methylprednisolone and hemodynamic control that lead to modest function recovery. Fumaric acid esters (FAEs) were firstly used in the management of an immunological skin disorder, such as psoriasis. Because of their potent anti-inflammatory effects, they have been introduced in multiple sclerosis. Investigation shown not only anti-inflammatory, but also supposed neuroprotective mechanism of action...
November 27, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27889817/paediatric-spinal-cord-infarction-a-review-of-the-literature-and-two-case-reports
#14
Asim Sheikh, Daniel Warren, Anne-Marie Childs, John Russell, Mark Liddington, Velupandian Guruswamy, Paul Chumas
Ischemic spinal cord infarction is rare in the paediatric population, and when it does occur, it is usually associated with traumatic injury. Other potential causes include congenital cardiovascular malformations, cerebellar herniation, thromboembolic disease and infection. Magnetic resonance imaging (MRI) findings can be subtle in the early evaluation of such patients. The outcome is variable and depends on the level and extent of the spinal cord infarct and subsequent rehabilitation. Here, we present two cases of ischemic spinal cord infarction in children...
November 26, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27886876/complications-in-the-management-of-patients-with-spine-trauma
#15
REVIEW
Geoffrey Stricsek, George Ghobrial, Jefferson Wilson, Thana Theofanis, James S Harrop
More than 50% of patients diagnosed with acute, traumatic spinal cord injury will experience at least 1 complication during their hospitalization. Age, severity of neurological injury, concurrent traumatic brain injury, comorbid illness, and mechanism of injury are all associated with increasing risk of complication. More than 75% of complications will occur within 2 weeks of injury. The complications associated with SCI carry a significant risk of morbidity and mortality; their early identification and management is critical in the care of the SCI patient...
January 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/27886871/update-on-new-imaging-techniques-for-trauma
#16
REVIEW
Lubdha M Shah, Adam E Flanders
Computed tomography (CT) and MRI are complementary imaging modalities for the evaluation of the traumatic spine. Osseous delineation is best assessed with CT, whereas MRI gives superb soft tissue description. Awareness of the strengths and pitfalls of each modality is critical in the accurate interpretation of images. Advances in MR imaging of the spine, particularly of the spinal cord, provide glimpses into to the pathobiological mechanism of spinal cord injury. Innovative techniques relay microstructural information about the integrity of the axons and myelin sheaths...
January 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/27884460/endogenous-spinal-cord-stem-cells-in-multiple-sclerosis-and-its-animal-model
#17
Ruxandra Covacu, Lou Brundin
The adult mammalian spinal cord (SC) harbors neural stem cells (NSCs). The SC-NSCs are mostly quiescent during physiological conditions but are quickly activated in traumatic injury models. The SC-NSCs generate mostly glia, but are able to differentiate into neurons when affected by favourable conditions. An example is the inflammatory milieu in the SC of rat EAE, where the SC-NSCs migrate into demyelinated lesions and give rise to both glia and neurons. In MS, cells with progenitor phenotypes accumulate in inflammatory lesions both in brain and SC, but the extent to which these cells contribute to repair remains to be revealed...
November 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27875566/labor-market-integration-of-people-with-disabilities-results-from-the-swiss-spinal-cord-injury-cohort-study
#18
Jan D Reinhardt, Marcel W M Post, Christine Fekete, Bruno Trezzini, Martin W G Brinkhof
OBJECTIVES: We aimed to describe labor market participation (LMP) of persons with spinal cord injury (SCI) in Switzerland, to examine potential determinants of LMP, and to compare LMP between SCI and the general population. METHODS: We analyzed data from 1458 participants of employable age from the cross-sectional community survey of the Swiss Spinal Cord Injury Cohort Study. Data on LMP of the Swiss general population were obtained from the Swiss Federal Statistical Office...
2016: PloS One
https://www.readbyqxmd.com/read/27857994/triple-trouble-a-case-of-traumatic-cervical-spinal-cord-injury-in-a-patient-with-ossification-of-posterior-longitudinal-ligament-and-disc-prolapse
#19
Kosar Hussain, Sally Khalid Ahmed Abu-Khumra, Firas Jaafar Kareem Alnajjar, Motea Mohamad Abdo
We describe the case of a trauma patient who presented to our emergency department with signs and symptoms suggestive of cervical cord injury. The patient had an underlying ossification of the posterior longitudinal ligament with multiple cervical disc prolapses from C3 to C7. The presence of these two factors increased the impact of the traumatic cervical cord injury. The patient underwent spinal decompression via laminectomy. Unfortunately, his neurological status did not show any significant improvement after the surgery...
September 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27857723/regeneration-associated-macrophages-a-novel-approach-to-boost-intrinsic-regenerative-capacity-for-axon-regeneration
#20
REVIEW
Min Jung Kwon, Hyuk Jun Yoon, Byung Gon Kim
Axons in central nervous system (CNS) do not regenerate spontaneously after injuries such as stroke and traumatic spinal cord injury. Both intrinsic and extrinsic factors are responsible for the regeneration failure. Although intensive research efforts have been invested on extrinsic regeneration inhibitors, the extent to which glial inhibitors contribute to the regeneration failure in vivo still remains elusive. Recent experimental evidence has rekindled interests in intrinsic factors for the regulation of regeneration capacity in adult mammals...
September 2016: Neural Regeneration Research
keyword
keyword
51564
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"