Read by QxMD icon Read

traumatic spinal cord injury

Alan D Cook, Jeanette G Ward, Kristina M Chapple, Hassan Akinbiyi, Mark Garrett, Forrest O'Dell Moore
BACKGROUND: Representing 2 % of the general population, American Indians/Alaska Natives (AIs/ANs) were associated with 0.5 % (63) of the estimated 12,500 new cases of spinal cord injury (SCI) reported to the National Spinal Cord Injury Statistic Center in 2013. To date, the trend in health care disparities among AIs/ANs in the SCI community has not been examined. We sought to compare the rate of discharge to rehabilitation facilities (DRF) following traumatic SCI among adult AIs/ANs to other racial/ethnic groups for patients 15 to 64 years old...
December 2015: Injury Epidemiology
Ala'a O Oteir, Karen Smith, Johannes U Stoelwinder, Shelley Cox, James W Middleton, Paul A Jennings
BACKGROUND: Traumatic Spinal Cord Injury (TSCI) is relatively uncommon, yet a devastating and costly condition. Despite the human and social impacts, studies describing patients with potential TSCI in the pre-hospital setting are scarce. This paper aims to describe the epidemiology of patients potentially at risk of or suspected to have a TSCI by paramedics, with a view to providing a better understanding of factors associated with potential TSCI. METHODS: This is a retrospective cohort study of all adult patients managed and transported by Ambulance Victoria (AV) between 01 January 2007 and 31 December 2012 who, based on meeting pre-hospital triage protocols and criteria for spinal clearance, paramedic suspicion or spinal immobilisation, were classified to be at risk of or suspected to have a TSCI...
December 2016: Injury Epidemiology
Zhicheng Wang, Jia Nong, Robert B Shultz, Zhiling Zhang, Veronica J Tom, Ravi K Ponnappan, Yinghui Zhong
Many mechanisms contribute to the secondary injury cascades following traumatic spinal cord injury (SCI). However, most current treatment strategies only target one or a few elements in the injury cascades, and have been largely unsuccessful in clinical trials. Minocycline hydrochloride (MH) is a clinically available antibiotic and anti-inflammatory drug that has been shown to target a broad range of secondary injury mechanisms via its anti-inflammatory, anti-oxidant, and anti-apoptotic properties. However, MH is only neuroprotective at high concentrations...
October 5, 2016: Biomaterials
Hao Yu, Lusheng Li, Raynald Liu, Bing Shu, Huizi Chen, Hua Huang, Rongrong Hua, Fenjun Jiang, Yihua An
Spinal cord injury (SCI) is a common disease worldwide that causes permanent neuronal dysfunction without an effective treatment. Long propriospinal neurons (LPSNs) that are spared from injury play a key role in spontaneous recovery after SCI. Traumatic injury of the central nervous system can activate autophagy, which could be a target in the development of a new therapeutic strategy to prevent neuronal loss. Our research focused on whether autophagy is involved in the loss of LPSNs after introducing spinal cord injury in adult rats...
October 12, 2016: Neuroscience Letters
Mohor B Sengupta, Suparna Saha, Pradeep K Mohanty, Kiran K Mukhopadhyay, Debashis Mukhopadhyay
ApoA1 is a player in reverse cholesterol transport that initiates multiple cellular pathways on binding to its receptor ABCA1. Its relation to neuronal injury is however unclear. We found ApoA1 to be increasingly abundant at a later time point in the secondary phase of traumatic spinal cord injury. In a cellular injury model of neuroblastoma, ApoA1 showed an initial diminished expression after infliction of injury, which sharply increased thereafter. Subsequently, ApoA1 was shown to alter wound healing dynamics in neuroblastoma injury model...
October 13, 2016: Molecular and Cellular Biochemistry
Behzad Sabit, Frederick Adam Zeiler, Neil Berrington
PURPOSE: To perform a scoping systematic review on the literature surrounding mean arterial pressure (MAP) and functional outcomes post traumatic acute spinal cord injury (ASCI). METHODS: We performed a systematic review of the literature via searching MEDLINE, BIOSIS, EMBASE, Global Health, SCOPUS, and Cochrane Library from inception to January 2015. We also performed a handsearch of various published meeting proceedings. Through a 2-step review process, employing 2 independent reviewers, we selected articles for the final review based on predefined inclusion/exclusion criteria...
October 12, 2016: Journal of Intensive Care Medicine
Habiba Aurang Zeb, Ishaq Nasib Khan, Iqbal Munir, Wafaa Saadeldin Ramadan, Mian Afaq Ahmad, Deema Hussein, Mohammad Amjad Kamal, Saleh Al Karim
Injuries to the spinal cord often have devastating physiological impacts due to the organ's vital role in neuro-impulse communications between muscles and the brain. Spinal Cord Injuries (SCIs) have recently been estimated to affect up to 80,000 individuals per year worldwide, with most occurring following a traumatic event. Unfortunately, effective treatments standardised globally for patients with SCIs have not yet been established. For many years, inadequate understanding of the complexities of the Central and Peripheral Nervous Systems and Neurogenesis has limited progression towards effective cures...
October 4, 2016: CNS & Neurological Disorders Drug Targets
Samira Saadoun, Marios C Papadopoulos
This paper challenges the current management of acute traumatic spinal cord injury based on our experience with monitoring from the injury site in the neurointensive care unit. We argue that the concept of bony decompression is inadequate. The concept of optimum spinal cord perfusion pressure, which differs between patients, is introduced. Such variability suggests individualized patient treatment. Failing to optimize spinal cord perfusion limits the entry of systemically administered drugs into the injured cord...
October 5, 2016: Critical Care: the Official Journal of the Critical Care Forum
Andrew Agbay, John M Edgar, Meghan Robinson, Tara Styan, Krista Wilson, Julian Schroll, Junghyuk Ko, Nima Khadem Mohtaram, Martin Byung-Guk Jun, Stephanie M Willerth
Ongoing clinical trials are evaluating the use of stem cells as a way to treat traumatic spinal cord injury (SCI). However, the inhibitory environment present in the injured spinal cord makes it challenging to achieve the survival of these cells along with desired differentiation into the appropriate phenotypes necessary to regain function. Transplanting stem cells along with an instructive biomaterial scaffold can increase cell survival and improve differentiation efficiency. This study reviews the literature discussing different types of instructive biomaterial scaffolds developed for transplanting stem cells into the injured spinal cord...
2016: Cells, Tissues, Organs
Nissar Shaikh, M A Rhaman, Ali Raza, Adel Shabana, Mahommad Faisal Malstrom, Ghanem Al-Sulaiti
BACKGROUND: High spinal cord injury (HSCI) is one of the devastating traumatic injuries. 80% of these patients are young male, and 93% will have major neurological disabilities. There is a paucity of literature about prolonged bradycardia in HSCI patients. The aim of this study was to know the prevalence, risk factors, precipitating factors for prolonged bradycardia in the HSCI patients. MATERIALS AND METHODS: All patients who were admitted to the Intensive Care Unit (ICU) of a tertiary hospital, with spinal cord injury above level of dorsal (D4) were enrolled in this study prospectively...
October 2016: Asian Journal of Neurosurgery
Rita Galeiras, Mónica Mourelo, Sonia Pértega, Amanda Lista, M Elena Ferreiro, Sebastián Salvador, Antonio Montoto, Antonio Rodríguez
BACKGROUND: Patients with acute traumatic spinal cord injuries (SCIs) exhibit factors that, in other populations, have been associated with rhabdomyolysis. PURPOSE: The aim of the study is to determine the incidence of rhabdomyolysis in patients with acute traumatic SCI admitted to the Intensive Care Unit (ICU), as well as the development of secondary acute kidney injury and associated factors. STUDY DESIGN AND SETTING: This was an observational, retrospective study...
September 2016: Indian Journal of Critical Care Medicine
David B Salisbury, Thomas D Parsons, Kimberley R Monden, Zina Trost, Simon J Driver
Purpose/Objective: To investigate the feasibility of brain-computer interface (BCI) with patients on an inpatient spinal cord injury (SCI) unit. Research Method/Design: This study included 25 participants aged 18-64 who sustained traumatic or nontraumatic SCI and did not have severe cognitive or psychiatric impairment. Participants completed a variety of screening measures related to cognition, psychological disposition, pain, and technology experience/interest. The Emotiv electroencephalography system was used in conjunction with a cube rotation and manipulation game presented on a laptop computer...
September 29, 2016: Rehabilitation Psychology
Antoine Zaczyk, Mathilde Prestini, Juliette Martel, Marjorie Deplanque, Céline Ramspacher, Samantha Demaille
OBJECTIVE: The high-level mobility assessment tool (HiMAT) was developed to quantify balance and mobility problems after traumatic brain injury (TBI). The revised HiMAT is valid for people with neurological diseases. The aim of this cohort study was to translate and investigate the internal consistency, reliability of the French version in people with neurological conditions. MATERIAL/PATIENTS AND METHODS: The original version of HiMAT was translated into French, cross-culturally adapted and field tested...
September 2016: Annals of Physical and Rehabilitation Medicine
Laila Mahir, Soumia Meftah, Siham Zahi, Herman Azanmasso, Fatima Lmidmani, Abdellatif El Fatimi
OBJECTIVE: Tuberculosis of the central nervous system is a major cause of morbidity and mortality in developing countries. Myelitis is the most common manifestation of spinal tuberculosis. OBJECTIVE: we report the epidemiological characteristics, clinical and functional aspects in a group of 14 patients with tuberculous myelitis after functional rehabilitation. MATERIALS/PATIENTS AND METHODS: Over a period of 4 years, 14 cases of tuberculous myelitis were admitted for functional rehabilitation...
September 2016: Annals of Physical and Rehabilitation Medicine
Charlotte Pineau, Brice Lavrard, François Boyer, Laëtitia Percebois-Macadré
OBJECTIVE: MRI has highly changed the assessment of post-traumatic syringomyelia (PTS), roughly estimated at 30% nowadays. Times to onset (TTO) symptoms are random. This case report describes how hyperhidrosis appeared and revealed PTS diagnosis. OBSERVATIONS: Mr M., 43-year-old, is rehabilitation inpatient after T10 AIS A spinal cord injury (SCI). Three months after this event, Mr M complains of acute hyperhidrosis crisis always located below the injury, which can occur at any time of the day, particularly when he moves...
September 2016: Annals of Physical and Rehabilitation Medicine
Michael Jones, Julie Gassaway
OBJECTIVE: Peer support is an important adjunct to clinical care for people with disabilities, and may help address barriers to community reintegration. Peers offer positive role models and the benefit of learning from shared experiences of living with disability. Despite potential benefits, peer support is not consistently integrated in the rehabilitation process. This presentation describes three interventions recommended by patients, and directed by peer mentors, to promote successful community transition after rehabilitation for traumatic spinal cord injury (SCI)...
September 2016: Annals of Physical and Rehabilitation Medicine
Caroline Voiry, Kathleen Charvier, Frédérique Courtois, Pascal Giraux, Corinne Berthelot-Del Aguila, Gille Rode
OBJECTIVE: Most French people think that disabled people do not have any sexual life in terms of pleasure and reproduction. Or sex contributes to a great part of each individual's well-being and health. In our study, we determined the reproductive sexuality of men with an exclusively traumatic spinal cord injury (SCI) treated at the Henry-Gabrielle Hospital in Saint-Genis-Laval from January 2000 to December 2010, who benefited, or not, from a sexological assessment. MATERIAL/PATIENTS AND METHODS: This is an observational and retrospective study on the number of births in a cohort of 320 men with SCI, aged from 18 to 45 years at the time of their accident and who have an exclusively traumatic SCI without any evolution...
September 2016: Annals of Physical and Rehabilitation Medicine
Angelos Papatheodorou, Adam B Stein, Matthew Bank, Cristina P Sison, Katie Gibbs, Peter Davies, Ona Bloom
Inflammation in traumatic spinal cord injury (SCI) has been proposed to promote damage acutely and oppose functional recovery chronically. However, we do not yet understand the signals that initiate or prolong inflammation in persons with SCI. High-Mobility Group Box 1 (HMGB1) is a potent systemic inflammatory cytokine, or "damage-associated molecular pattern molecule" (DAMP) studied in a variety of clinical settings. It is elevated in pre-clinical models of traumatic spinal cord injury (SCI), where it promotes secondary injury, and strategies that block HMGB1 improve functional recovery...
September 27, 2016: Journal of Neurotrauma
Chong Tae Kim, James R Wilson, Deborah Mowery
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"