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traumatic spinal cord injury

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https://www.readbyqxmd.com/read/29774197/paraplegia-following-spinal-cord-contusion-from-an-indirect-gunshot-injury
#1
Khuram Khan, Beatrice Dieudonne, Saqib Saeed, Sara Alothman, Yasir Saeed, Sanjiv Gray
Spinal cord injuries are debilitating and life threatening. Paraplegia due to direct traumatic gunshot injury to the spinal cord is common. The most common cause of spinal cord injury is road traffic accidents. This is followed by spinal cord injury due to a fall from a height. Most of the spinal cord injuries due to gunshot wounds occur as a result of direct traumatic effects. We present a rare case of a 49-year-old male with trauma. He developed paraplegia after a gunshot wound injury to the neck and contusion to the spinal cord, with no direct trauma...
April 2018: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29773299/diffusion-mri-in-acute-nervous-system-injury
#2
Matthew D Budde, Nathan P Skinner
Diffusion weighted magnetic resonance imaging (DWI) and related techniques such as diffusion tensor imaging (DTI) are uniquely sensitive to the microstructure of the brain and spinal cord. In the acute aftermath of nervous system injury, for example, DWI reveals changes caused by injury that remains invisible on other MRI contrasts such as T2 -weighted imaging. This ability has led to a demonstrated clinical utility in cerebral ischemia. However, despite strong promise in preclinical models and research settings, DWI has not been as readily adopted for other acute injuries such as traumatic spinal cord, brain, or peripheral nerve injury...
April 30, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29765407/effects-of-transplanted-heparin-poloxamer-hydrogel-combining-dental-pulp-stem-cells-and-bfgf-on-spinal-cord-injury-repair
#3
Lihua Luo, Abdullkhaleg Ali Albashari, Xiaoyan Wang, Ling Jin, Yanni Zhang, Lina Zheng, Jianjian Xia, Helin Xu, Yingzheng Zhao, Jian Xiao, Yan He, Qingsong Ye
Spinal cord injury (SCI) is one of serious traumatic diseases of the central nervous system and has no effective treatment because of its complicated pathophysiology. Tissue engineering strategy which contains scaffolds, cells, and growth factors can provide a promising treatment for SCI. Hydrogel that has 3D network structure and biomimetic microenvironment can support cellular growth and embed biological macromolecules for sustaining release. Dental pulp stem cells (DPSCs), derived from cranial neural crest, possess mesenchymal stem cell (MSC) characteristics and have an ability to provide neuroprotective and neurotrophic properties for SCI treatment...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29763914/epidemiology-of-traumatic-spinal-cord-injury-in-ireland-2010-2015
#4
Eimear Smith, Patricia Fitzpatrick, John Murtagh, Frank Lyons, Seamus Morris, Keith Synnott
BACKGROUND: The International Spinal Cord Society and World Health Organisation recommend the collection of epidemiological data on traumatic spinal cord injury (TSCI). A 1-year prospective study is ongoing in Ireland. While the results of this study are awaited, it was concluded from a feasibility exercise that a complete retrospective dataset, 2010-2015, could be obtained and would be useful for service planning. METHODS: All patients with TSCI discharged from the national SCI acute and rehabilitation centres were included...
May 15, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29760965/age-and-other-risk-factors-influencing-long-term-mortality-in-patients-with-traumatic-cervical-spine-fracture
#5
Matthew Bank, Katie Gibbs, Cristina Sison, Nawshin Kutub, Angelos Paptheodorou, Samuel Lee, Adam Stein, Ona Bloom
Objective: To identify clinical or demographic variables that influence long-term mortality, as well as in-hospital mortality, with a particular focus on the effects of age. Summary and Background Data: Cervical spine fractures with or without spinal cord injury (SCI) disproportionately impact the elderly who constitute an increasing percentage of the US population. Methods: We analyzed data collected for 10 years at a state-designated level I trauma center to identify variables that influenced in-hospital and long-term mortality among elderly patients with traumatic cervical spine fracture with or without SCI...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29760552/patients-receiving-chiropractic-care-in-a-neurorehabilitation-hospital-a-descriptive-study
#6
Robert D Vining, Stacie A Salsbury, W Carl Cooley, Donna Gosselin, Lance Corber, Christine M Goertz
Objectives: Individuals rehabilitating from complex neurological injury require a multidisciplinary approach, which typically does not include chiropractic care. This study describes inpatients receiving multidisciplinary rehabilitation including chiropractic care for brain injury, spinal cord injury (SCI), stroke, and other complex neurological conditions. Design: Chiropractic services were integrated into Crotched Mountain Specialty Hospital (CMSH) through this project...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29759918/potential-immunotherapies-for-traumatic-brain-and-spinal-cord-injury
#7
REVIEW
Raj Putatunda, John R Bethea, Wen-Hui Hu
Traumatic injury of the central nervous system (CNS) including brain and spinal cord remains a leading cause of morbidity and disability in the world. Delineating the mechanisms underlying the secondary and persistent injury versus the primary and transient injury has been drawing extensive attention for study during the past few decades. The sterile neuroinflammation during the secondary phase of injury has been frequently identified substrate underlying CNS injury, but as of now, no conclusive studies have determined whether this is a beneficial or detrimental role in the context of repair...
April 18, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29759026/efficacy-of-oligodendrocyte-progenitor-cell-transplantation-in-rat-models-with-traumatic-thoracic-spinal-cord-injury-a-systematic-review-and-meta-analysis
#8
Haitao Fu, Die Hu, Licheng Zhang, Xuezhen Shen, Peifu Tang
Spinal cord injury (SCI) is a devastating disease that results in severe motor, sensory, and autonomic dysfunction, for which there is currently no available treatments. Following the primary mechanical damage, progressive secondary damage further exacerbates the functional deficit. Demyelination may play an important role in the pathogenesis of SCI. Oligodendrocyte progenitor cells (OPCs) are considered a candidate cellular treatment approach for SCI due to their unique potential. Here, we conducted a systematic review and meta-analysis to assess the efficacy of OPC transplantation in rat models with traumatic thoracic SCI and 17 studies (20 experiments, 402 rats) were identified...
May 15, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29752910/describing-functioning-in-people-living-with-spinal-cord-injury-in-switzerland-a-graphical-modelling-approach
#9
Cristina Ehrmann, Birgit Prodinger, Hans Peter Gmünder, Kerstin Hug, Jerome E Bickenbach, Gerold Stucki
OBJECTIVE: To describe functioning in people living with spinal cord injury (SCI) in Switzerland. DESIGN: Secondary analysis of cross-sectional survey data. SETTING: Community, Switzerland. PARTICIPANTS: Individuals (N=1549) who were 16 years or older with a history of traumatic or non-traumatic SCI and have a permanent residence in Switzerland. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Functioning was operationalized through four domains: impairments in body functions (measured with the SCI Secondary Conditions Scale); mental functions (Mental Health sub-scale of the SF-36); independence in performing activities (SCI Independence Measure Self-Report); performance problems in participation (Utrecht Scale for Evaluation Rehabilitation-Participation)...
May 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29752515/epidemiology-and-pathophysiology-of-neurogenic-bladder-after-spinal-cord-injury
#10
Rizwan Hamid, Marcio Augusto Averbeck, Humberto Chiang, Arturo Garcia, Riyad T Al Mousa, Seung-June Oh, Anita Patel, Mauricio Plata, Giulio Del Popolo
Spinal cord injury (SCI) usually affects younger age groups with male preponderance. The most common traumatic cause is road traffic accident followed by sports accidents and gun-shot injuries. Infections and vascular events make up non-traumatic causes. There is regional variance in incidence and prevalence of SCI. Most systematic reviews have been undertaken from USA, Canada, and Australia with only few from Asia with resultant difficulty in estimation of worldwide figures. Overall, the incidence varies from 12 to more than 65 cases/million per year...
May 11, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29745625/assessment-of-neurogenic-bowel-dysfunction-impact-after-spinal-cord-injury-using-the-international-classification-of-functioning-disability-and-health
#11
Jennifer M Pires, Ana M Ferreira, Filipa Rocha, Luis G Andrade, Inês Campos, Paulo Margalho, Jorge Laíns
BACKGROUND: Bowel function is frequently compromised after spinal cord injury (SCI). Regardless of this crucial importance in patients' lives, there is still scarce literature on the Neurogenic Bowel Dysfunction (NBD) deleterious impact on SCI patient's lives and only few studies correlating NBD severity with quality of life (QoL). To our knowledge there are no studies assessing the impact of NBD on the context of ICF domains. AIM: To assess NBD after SCI using ICF domains and to assess its impact in QoL...
May 9, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29740239/role-of-ct-scan-in-theranostic-and-management-of-traumatic-spinal-cord-injury
#12
Daryoush Fatehi, Mohammad Ali Dayani, Ayoob Rostamzadeh
Traumatic spinal cord injury (TSCI) is a condition with suffering of neural structures from acute trauma with short-term or permanent sensory and motor problems. This study was conducted with the aim of determining the prevalence of TSCI in Tehran with emphasis on demographic characteristics of patients and to evaluate the effect of computed tomography (CT) in determining fracture type and severity grade of injury among TSCI patients. In a cross-sectional study, all TSCI and spinal fracture patients ( N  = 520) who referred to the main trauma center in Tehran, Iran, in 2013 and 2014 were selected...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29736858/clinical-trials-in-traumatic-spinal-cord-injury
#13
REVIEW
Jayne Donovan, Steven Kirshblum
Traumatic spinal cord injury (SCI) results in impaired neurologic function that for many individuals is permanent and significantly impacts health, function, quality of life, and life expectancy. Many efforts have been taken to develop effective treatments for SCI; nevertheless, proven therapies targeting neurologic regeneration and functional recovery have been limited. Existing therapeutic approaches, including early surgery, strict blood pressure control, and consideration of treatment with steroids, remain debated and largely focus on mitigating secondary injury after the primary trauma has occurred...
May 7, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29732213/association-between-detrusor-muscle-function-and-level-of-the-spinal-cord-injury
#14
Maryam Kooshesh, Mahdi Safdarian, Abolghasem Nikfallah, Alexander R Vaccaro, Vafa Rahimi-Movaghar
Introduction: Traumatic spinal cord injury (TSCI) is among the most severe disabilities with an estimation of 2.5 million people affected worldwide. The purpose of this study was to investigate the association between detrusor muscle function and the level of the spinal cord injury. Material and methods: All patients with TSCI who underwent urodynamic evaluation at the Brain and Spinal Injury Research Center (BASIR) of Imam Khomeini hospital complex from March 2014 to March 2016 were retrospectively entered in this cross-sectional study...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29729417/compressive-mechanical-characterization-of-non-human-primate-spinal-cord-white-matter
#15
Shervin Jannesar, Mark Allen, Sarah Mills, Anne Gibbons, Jacqueline C Bresnahan, Ernesto A Salegio, Carolyn J Sparrey
The goal of developing computational models of spinal cord injury (SCI) is to better understand the human injury condition. However, finite element models of human SCI have used rodent spinal cord tissue properties due to a lack of experimental data. Central nervous system tissues in non human primates (NHP) closely resemble that of humans and therefore, it is expected that material constitutive models obtained from NHPs will increase the fidelity and the accuracy of human SCI models. Human SCI most often results from compressive loading and spinal cord white matter properties affect FE predicted patterns of injury; therefore, the objectives of this study were to characterize the unconfined compressive response of NHP spinal cord white matter and present an experimentally derived, finite element tractable constitutive model for the tissue...
May 2, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29719837/epidemiological-characteristics-of-traumatic-spinal-cord-injury-tsci-in-the-middle-east-and-north-africa-mena-region-a-systematic-review-and-meta-analysis
#16
REVIEW
Mohamed H Elshahidi, Nada Y Monir, Mohamed A Elzhery, Ahmed A Sharaqi, Hames Haedaya, Basem I Awad, Khaled Zaghloul
Objective: To systematically search the literature and to summarize current evidence pertaining to the epidemiology of SCI in the MENA region incidence, gender, age, type of the injury and etiology of the injury. Methods: Embase, PubMed, Scopus, Web of Science and EBSCOhost were systematically searched from their dates of inception till July 2017 for English and non-English language articles. Also, regional databases were searched. Data were extracted from eligible articles and pooled under the random effect model using R ...
April 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29714644/functional-outcomes-in-patients-with-co-occurring-traumatic-brain-injury-and-spinal-cord-injury-from-an-inpatient-rehabilitation-facility-s-perspective
#17
Kristin L Garlanger, Lisa A Beck, Andrea L Cheville
OBJECTIVE: To examine the occurrence and severity of co-occurring traumatic brain injury (TBI) in persons with traumatic spinal cord injury (SCI), i.e. dual diagnosis (DD), and to describe differences in functional outcomes between persons with DD and SCI only from an inpatient rehabilitation facility (IRF) perspective. DESIGN: Retrospective clinical chart review. SETTING: Acute Midwest SCI inpatient rehabilitation facility. PARTICIPANTS: 256 persons age 18-80 years with acute traumatic SCI (AIS A-E, C1-S3 level of injury) from 2002-2012...
May 1, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29712534/a-scoping-review-on-health-economics-in-neurosurgery-for-acute-spine-trauma
#18
Brian C F Chan, B Catharine Craven, Julio C Furlan
OBJECTIVE Acute spine trauma (AST) has a relatively low incidence, but it often results in substantial individual impairments and societal economic burden resulting from the associated disability. Given the key role of neurosurgeons in the decision-making regarding operative management of individuals with AST, the authors performed a systematic search with scoping synthesis of relevant literature to review current knowledge regarding the economic burden of AST. METHODS This systematic review with scoping synthesis included original articles reporting cost-effectiveness, cost-utility, cost-benefit, cost-minimization, cost-comparison, and economic analyses related to surgical management of AST, whereby AST is defined as trauma to the spine that may result in spinal cord injury with motor, sensory, and/or autonomic impairment...
May 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29708005/microrna-based-therapeutics-in-central-nervous-system-injuries
#19
Ping Sun, Da Zhi Liu, Glen C Jickling, Frank R Sharp, Ke-Jie Yin
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), are important causes of death and long-term disability worldwide. MicroRNA (miRNA), small non-coding RNA molecules that negatively regulate gene expression, can serve as diagnostic biomarkers and are emerging as novel therapeutic targets for CNS injuries. MiRNA-based therapeutics include miRNA mimics and inhibitors (antagomiRs) to respectively decrease and increase the expression of target genes...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29706957/microglia-and-beyond-innate-immune-cells-as-regulators-of-brain-development-and-behavioral-function
#20
REVIEW
Kathryn M Lenz, Lars H Nelson
Innate immune cells play a well-documented role in the etiology and disease course of many brain-based conditions, including multiple sclerosis, Alzheimer's disease, traumatic brain and spinal cord injury, and brain cancers. In contrast, it is only recently becoming clear that innate immune cells, primarily brain resident macrophages called microglia, are also key regulators of brain development. This review summarizes the current state of knowledge regarding microglia in brain development, with particular emphasis on how microglia during development are distinct from microglia later in life...
2018: Frontiers in Immunology
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