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https://www.readbyqxmd.com/read/29793087/skin-allografting-activates-anti-tumor-immunity-and-suppresses-growth-of-colon-cancer-in-mice
#1
Xiang Li, Xu Lan, Grace Wang, Yi Liu, Ke Zhao, Shan-Zheng Lu, Xiao-Xi Xu, Gang-Gang Shi, Kui Ye, Bao-Ren Zhang, Yi-Ming Zhao, Hong-Qiu Han, Cai-Gan Du, Thomas E Ichim, Hao Wang
INTRODUCTION: The tumor cells could escape from the immune elimination through the immunoediting mechanisms including the generation of immunosuppressive or immunoregulative cells. By contrast, allograft transplantation could activate the immune system and induce a strong allogenic response. The aim of this study was to investigate the efficacy of allogenic skin transplantation in the inhibition of tumor growth through the activation of allogenic immune response. METHODS: Full-thickness skin transplantation was performed from C57BL/6 (H-2b ) donors to BALB/c (H-2d ) recipients that were receiving subcutaneous injection of isogenic CT26 colon cancer cells (2 × 106 cells) at the same time...
May 21, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29792746/high-resolution-ct-findings-of-obstructive-and-restrictive-phenotypes-of-chronic-lung-allograft-dysfunction-more-than-just-bronchiolitis-obliterans-syndrome
#2
Partha Hota, Chandra Dass, Maruti Kumaran, Scott Simpson
OBJECTIVE: The purpose of this article is to review the high-resolution CT characteristics of individual obstructive and restrictive chronic lung allograft dysfunction (CLAD) phenotypes to aid in making accurate diagnoses and guiding treatment. CONCLUSION: Long-term survival and function after lung transplant are considerably worse compared with after other organ transplants. CLAD is implicated as a major limiting factor for long-term graft viability. Historically thought to be a single entity, bronchiolitis obliterans syndrome, CLAD is actually a heterogeneous group of disorders with distinct subtypes...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792070/chondral-delamination-of-fresh-osteochondral-allografts-after-implantation-in-the-knee-a-matched-cohort-analysis
#3
Ryan C Rauck, Dean Wang, Matthew Tao, Riley J Williams
Introduction Delamination of the chondral surface of an osteochondral allograft (OCA) from the underlying cancellous bone has been described as a mode of failure after implantation in the knee. Our hypothesis was that increased storage time of the OCA is associated with increased risk of graft delamination after implantation. Methods Prospective data on 13 patients with evidence of OCA delamination identified on magnetic resonance imaging or during subsequent surgery from 2000 to 2015 were reviewed. A cohort of 33 patients without evidence of graft delamination were then matched to the delamination group based on recipient age, sex, body mass index (BMI), and chondral defect location...
May 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29791703/biological-intercalary-reconstruction-with-bone-grafts-after-joint-sparing-resection-of-the-lower-limb-is-this-an-effective-and-durable-solution-for-joint-preservation
#4
Francesco Muratori, Francesca Totti, Antonio D'Arienzo, Maurizio Scorianz, Guido Scoccianti, Giovanni Beltrami, Francesco Rosario Campo, Carmine Citarelli, Rodolfo Capanna, Domenico Andrea Campanacci
Due to advances in neoadjuvant therapies and preoperative imaging modalities, joint-sparing resections have become appealing in bone tumor surgery. However, the intercalary reconstruction of metadiaphyseal bone defects of the femur and the tibia after juxta-articular tumor resection remains challenging. Both biological and prosthetic reconstructions have been used for joint-sparing resections, but little is known about the long-term outcome of these procedures. The authors reviewed a consecutive series of 64 patients treated with joint-sparing intercalary resection and reconstruction with bone grafts...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791589/non-invasive-messenger-rna-transcriptional-evaluation-in-human-kidney-allograft-dysfunction
#5
G Joelsons, T Domenico, L F Gonçalves, R C Manfro
The aim of the present study was to evaluate messenger RNA expression in kidney allograft recipients. Forty-four kidney transplant recipients were evaluated up to three months after grafting. After transplantation, peripheral blood samples were drawn sequentially for real-time polymerase chain reaction analyses of perforin and TIM-3 genes. Biopsies were obtained to evaluate acute graft dysfunction and interpreted according to the Banff classification. Eight patients presented episodes of acute rejection. Recipients with rejection had significantly higher levels of TIM-3 mRNA transcripts compared to those without rejection (median gene expression 191...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29791060/implementing-an-innovated-preservation-technology-the-american-society-of-transplant-surgeons-asts-standards-committee-white-paper-on-ex-situ-liver-machine-perfusion
#6
Cristino Quintini, Paulo Martins, Shimul Shah, Mary Killackey, Alan Reed, James Guarrera, David A Axelrod
The pervasive shortage of deceased donor liver allografts contributes to significant waitlist mortality despite efforts to increase organ donation. Ex-vivo liver perfusion appears to enhance preservation of donor organs, extending viability, and, potentially, evaluating function in organs previously considered too high risk for transplant. These devices pose novel challenges for organ allocation, safety, training, and finances. This White Paper describes the American Society of Transplant Surgeons' belief that organ preservation technology is a vital advance, but its use should not change fundamental aspects of organ allocation...
May 23, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29791046/impact-of-intensive-dosing-of-mycophenolate-on-pancreas-allograft-survival
#7
Jillian L Descourouez, Margaret Jorgenson, Nathan Menninga, Glen Leverson, Jon Odorico, Robert Redfield
PURPOSE: Evaluate the effect of mycophenolate (mycophenolic acid, MPA) dose on pancreas allograft survival following simultaneous pancreas kidney (SPK) transplant. METHODS: This was an observational study of adult SPK recipients transplanted between 1/1/2002-6/30/2015. Recipients were divided into cohorts based on MPA dose at discharge; high dose (HD) 1000mg three times daily mycophenolate mofetil (MMF) and standard dose (SD) 1000mg twice daily MMF. Primary outcome was pancreas allograft survival...
May 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29789580/the-effects-of-anti-lap-monoclonal-antibody-down-regulation-of-cd4-lap-t-cells-on-allogeneic-corneal-transplantation-in-mice
#8
Shang Li, Hongshuang Lu, Ruti Sella, Wei Zhang, Hongwei Dong, Chungang Guo, Natalie A Afshari, Zhiqiang Pan, Ying Jie
CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to a decrease in the percentage of T cells expressing CD4+Foxp3+, CD4+GARP+, CD4+LAP+ and CD4+IL-10+ in the lymph nodes and spleens of mice undergoing orthotopic penetrating transplantation of corneal allograft, without affecting corneal graft survival...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789350/regulatory-t-cells-and-kidney-transplantation
#9
REVIEW
Paloma Leticia Martin-Moreno, Sudipta Tripathi, Anil Chandraker
The ability of the immune system to differentiate self from nonself is critical in determining the immune response to antigens expressed on transplanted tissue. Even with conventional immunosuppression, acceptance of the allograft is an active process often determined by the presence of regulatory T cells (Tregs). Tregs classically are CD4+ cells that constitutively express high levels of the IL-2 receptor α chain CD25, along with the transcription factor Foxp3. The use of Tregs in the field of solid organ transplantation is related specifically to the objective of achieving tolerance, with the goal of reducing or eliminating immunosuppressive drugs as well as maintaining tissue repair and managing acute rejection...
May 22, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29788896/association-between-delayed-graft-function-dgf-biomarkers-and-long-term-outcomes-after-living-donor-kidney-transplantation
#10
Zahra Sahraei, Mona Mehdizadeh, Jamshid Salamzadeh, Mohsen Nafar, Azadeh Eshraghi
BACKGROUND AND OBJECTIVES: The Association between preoperative Urine Neutrophil Gelatinase-associated Lipocalin (uNGAL) and interlukin-18 (uIL-18) with poor 1-year allograft function has been shown in deceased-donor kidney transplant recipients previously, and also these markers could predict 3-month allograft function. However, it is unknown whether there is any association between these postoperative biomarkers with important recipient outcomes beyond this time in live-donor transplants...
May 21, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29788811/central-ecmo-for-circulatory-failure-following-pediatric-liver-transplantation
#11
John P Scott, Johnny C Hong, Nathan E Thompson, Ronald K Woods, George M Hoffman
We describe the case of a 4-year-old male with a past medical history significant for nephrotic syndrome, short-bowel syndrome and fulminant hepatic failure status post (s/p) liver transplant (LT) who developed early post-transplant allograft dysfunction (hyperbilirubinemia, coagulopathy) and septic shock requiring central extracorporeal membrane oxygenation (ECMO). He remained on ECMO for 85 hours before he was decannulated without event and later underwent repeat LT. This case highlights the potential of central ECMO to provide the circulatory output necessary to reverse distributive shock physiology in patients with sepsis and hepatic dysfunction following LT...
May 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29788012/allograft-inflammatory-factor-1-mediates-macrophage-induced-impairment-of-insulin-signaling-in-adipocytes
#12
Jingqi Ren, Yaqiu Lin, Junni Tang, Hua Yue, Yanying Zhao
BACKGROUND/AIMS: Allograft inflammatory factor-1 (AIF-1) is an inflammatory cytokine produced mainly by macrophages within human white adipose tissue. Its expression is increased in obese subjects and positively correlated with insulin resistance. The purpose of this study is to characterize the regulatory role of AIF-1 in insulin signaling of adipocyte. METHODS: AIF-1 was over-expressed via transfection of AIF-1 cDNA into murine RAW 264.7 macrophages, and the constitutive expression of AIF-1 was decreased via transfection of targeting siRNA...
May 18, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29785313/management-of-an-infected-nonunion-of-an-opening-wedge-high-tibial-osteotomy-with-2-stage-implantation-of-rotating-hinge-knee-prosthesis
#13
Sandrine Mariaux, Olivier Borens
Introduction: High tibial osteotomy (HTO) is a frequent and effective treatment for unicompartmental gonarthritis. Only a few articles are focused on the treatment of infected nonunion. Patient and Method: A 50-year-old obese patient was operated on by medial opening-wedge HTO. She developed a painful nonunion treated by hardware removal, allograft, and plate fixation. However, the nonunion persisted. 2 years later, cellulitis appeared with an abscess adjacent to the HTO plate...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29784586/ultrasound-mediated-gene-delivery-enhances-tendon-allograft-integration-in-mini-pig-ligament-reconstruction
#14
Maxim Bez, Thomas J Kremen, Wafa Tawackoli, Pablo Avalos, Dmitriy Sheyn, Galina Shapiro, Joseph C Giaconi, Shiran Ben David, Jess G Snedeker, Zulma Gazit, Katherine W Ferrara, Dan Gazit, Gadi Pelled
Ligament injuries occur frequently, substantially hindering routine daily activities and sports participation in patients. Surgical reconstruction using autogenous or allogeneic tissues is the gold standard treatment for ligament injuries. Although surgeons routinely perform ligament reconstructions, the integrity of these reconstructions largely depends on adequate biological healing of the interface between the ligament graft and the bone. We hypothesized that localized ultrasound-mediated, microbubble-enhanced therapeutic gene delivery to endogenous stem cells would lead to significantly improved ligament graft integration...
April 26, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29784177/conjunctival-limbal-allografts-in-graft-versus-host-disease-using-same-hla-identical-bone-marrow-transplantation-donor
#15
Albert Y Cheung, Brad M Genereux, Nicholas J Auteri, Enrica Sarnicola, Amit Govil, Edward J Holland
No abstract text is available yet for this article.
June 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29783997/graft-protective-effect-and-induction-of-cd4-foxp3-cell-by-thrombomodulin-on-allograft-arteriosclerosis-in-mice
#16
Enzhi Yin, Shigefumi Matsuyama, Masateru Uchiyama, Kento Kawai, Masanori Niimi
BACKGROUND: Thrombomodulin (TM) is a promising therapeutic natural anti-coagulant, which exerts the effects to control disseminated intravascular coagulation. However, little is known whether TM on micro-vessels could play an important role in the regulation of intimal hyperplasia. We investigated the vessel-protective effect of TM in the survival of fully major histocompatibility complex (MHC)-mismatched murine cardiac allograft transplantation. METHODS: CBA recipients transplanted with a C57BL/6 heart received intraperitoneal administration of normal saline or 0...
May 21, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29781951/t-bet-or-ifn%C3%AE-neutralization-for-blocking-islet-allograft-rejection
#17
Alain Le Moine
No abstract text is available yet for this article.
April 30, 2018: Transplantation
https://www.readbyqxmd.com/read/29781949/optn-vascularized-composite-allograft-vca-waiting-list-current-status-and-trends-in-the-united-states
#18
Jennifer L Wainright, Christopher L Wholley, Wida S Cherikh, Jennifer M Musick, David K Klassen
BACKGROUND: Vascularized Composite Allograft (VCA) transplantation is a developing area in the field of transplantation. METHODS: This study used Organ Procurement and Transplantation Network (OPTN) VCA waiting list and transplant data from July 3, 2014 through February 28, 2018 to characterize the OPTN VCA waiting list in terms of composition, removal patterns, waiting time, resulting transplants, and trends over time. RESULTS: Between implementation of the OPTN VCA waiting list on July 3, 2014 and February 28, 2018, 54 candidates - 53...
April 30, 2018: Transplantation
https://www.readbyqxmd.com/read/29781850/comparing-processed-nerve-allografts-and-assessing-their-capacity-to-retain-and-release-nerve-growth-factor
#19
Alonda C Pollins, Richard B Boyer, Marlieke Nussenbaum, Wesley P Thayer
Peripheral nerve gap injuries continue to present a clinical challenge to today's surgeons. One method of surgical repair, implantation of acellular allografts, has been developed with the aim of bridging the gap with a cadaveric graft after removal of its cellular components, thereby accelerating axonal regeneration and eliminating the need for immunosuppression in recipient patients. Although decellularizing allografts reduces rates of graft rejection, the same chemical processing modifies the neural microenvironment, removing neutrotrophic factors and modifying the complex extracellular matrix...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29781811/spleen-derived-classical-monocytes-mediate-lung-ischemia-reperfusion-injury-through-il-1%C3%AE
#20
Hsi-Min Hsiao, Ramiro Fernandez, Satona Tanaka, Wenjun Li, Jessica H Spahn, Stephen Chiu, Mahzad Akbarpour, Daniel Ruiz-Perez, Qiang Wu, Cem Turam, Davide Scozzi, Tsuyoshi Takahashi, Hannah P Luehmann, Varun Puri, G R Scott Budinger, Alexander S Krupnick, Alexander V Misharin, Kory J Lavine, Yongjian Liu, Andrew E Gelman, Ankit Bharat, Daniel Kreisel
Ischemia-reperfusion injury, a form of sterile inflammation, is the leading risk factor for both short-term mortality following pulmonary transplantation and chronic lung allograft dysfunction. While it is well recognized that neutrophils are critical mediators of acute lung injury, processes that guide their entry into pulmonary tissue are not well understood. Here, we found that CCR2+ classical monocytes are necessary and sufficient for mediating extravasation of neutrophils into pulmonary tissue during ischemia-reperfusion injury following hilar clamping or lung transplantation...
May 21, 2018: Journal of Clinical Investigation
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