Ziyou Wu, Jian Zhang, Ziyao Jia, Ziyi Yang, Shilei Liu, Huakai Wang, Cheng Zhao, Jingwei Zhao, Qiuyi Tang, Yichen Xiong, Yue Yang, Yu Zhang, Zhe Zhou, Juanqing Yue, Fan Xiao, Quan Sun, Albie Gong, Wenyan Yao, Huaifeng Li, Xiaoling Song, Yuanyuan Ye, Yidi Zhu, Ping Dong, Fei Ma, Xiangsong Wu, Wei Gong
Liver metastasis is common in patients with gallbladder cancer (GBC), imposing a significant challenge in clinical management and serving as a poor prognostic indicator. However, the mechanisms underlying liver metastasis remain largely unknown. Here, we report a crucial role of tyrosine aminotransferase (TAT) in liver metastasis of GBC. TAT is frequently up-regulated in GBC tissues. Increased TAT expression is associated with frequent liver metastasis and poor prognosis of GBC patients. Overexpression of TAT promotes GBC cell migration and invasion in vitro, as well as liver metastasis in vivo...
April 30, 2024: Cancer Letters