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https://www.readbyqxmd.com/read/28075461/resistance-of-interleukin-6-to-the-extracellular-inhibitory-environment-promotes-axonal-regeneration-and-functional-recovery-following-spinal-cord-injury
#1
Gang Yang, Wen-Yuan Tang
Interleukin-6 (IL)-6 was originally discovered as a factor that contributes to the secondary pathological and inflammatory response in the central nervous system (CNS) following injury. However, accumulating evidence suggests that IL-6 is also involved in functional and structural recovery following CNS injury by promoting axonal sprou-ting. This suggests a potential dual role of IL-6 in CNS injury. However, the definitive function of IL-6 in neural injury and the corresponding underlying mechanisms are still topics of controversy...
January 5, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28068323/the-nogo-b-receptor-promotes-ras-plasma-membrane-localization-and-activation
#2
B Zhao, W Hu, S Kumar, P Gonyo, U Rana, Z Liu, B Wang, W Q Duong, Z Yang, C L Williams, Q R Miao
The localization of prenylated Ras at the plasma membrane promotes activation of Ras by receptor tyrosine kinases and stimulates oncogenic signaling by mutant Ras. The Nogo-B receptor (NgBR) is a transmembrane receptor that contains a conserved hydrophobic pocket. Here, we demonstrate that the NgBR promotes the membrane accumulation of Ras by directly binding prenylated Ras at the plasma membrane. We show that NgBR knockdown diminishes the membrane localization of Ras in multiple cell types. NgBR overexpression in NIH-3T3 fibroblasts increases membrane-associated Ras, induces the transformed phenotype in vitro, and promotes the formation of fibrosarcoma in nude mice...
January 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28051106/u24-from-roseolovirus-interacts-strongly-with-nedd4-ww-domains
#3
Yurou Sang, Rui Zhang, Walter R P Scott, A Louise Creagh, Charles A Haynes, Suzana K Straus
U24 is a protein found in both roseoloviruses Human Herpes Virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminus that is rich in prolines (PY motif in both HHV-6A and 7; PxxP motif in HHV-6A). Previous work has shown that the interaction between U24 and WW domains is important for endocytic recycling of T-cell receptors, but a cognate ligand was never identified. In this contribution, data was obtained from pull-downs, ITC, NMR and molecular dynamics simulations to show that a specific interaction exists between U24 and Nedd4 WW domains...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28000762/axonal-branching-in-lateral-olfactory-tract-is-promoted-by-nogo-signaling
#4
Masumi Iketani, Takaakira Yokoyama, Yuji Kurihara, Stephen M Strittmatter, Yoshio Goshima, Nobutaka Kawahara, Kohtaro Takei
Mitral cells are major projection neurons of the olfactory bulb (OB) that form an axonal bundle known as the lateral olfactory tract (LOT). After axonal bundle formation, collateral branches sprout from primary axons of the LOT. Recently, we identified LOT usher substance (LOTUS) as an endogenous Nogo receptor-1 (NgR1) antagonist and demonstrated that LOTUS contributes to the formation of the LOT axonal bundle. Immunoblots revealed that the expression level of Nogo-A in the OB developmentally increased during axonal collateral formation...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27990434/cornel-iridoid-glycoside-improves-locomotor-impairment-and-decreases-spinal-cord-damage-in-rats
#5
Wen-Jing Tang, Deng-Lei Ma, Cui-Cui Yang, Li Zhang, Ya-Li Li, Lan Zhang, Lin Li
Purpose. This study was to investigate the effects of cornel iridoid glycoside (CIG) on spinal cord injury (SCI) in rats. Methods. The thoracic cord (at T9) of rats was injured by clip compression for 30 sec. Locomotor function was assessed using the Basso, Beattie, and Bresnahan (BBB) rating scale. Neuroanatomic stereological parameters as well as Nogo-A, p75 neurotrophin receptor (p75NTR), and ROCKII expression were measured by histological processing, immunohistochemistry, and stereological analyses. The axons passing through the lesion site were detected by BDA tracing...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27956620/nogo-receptor-blockade-overcomes-remyelination-failure-after-white-matter-stroke-and-stimulates-functional-recovery-in-aged-mice
#6
Elif G Sozmen, Shira Rosenzweig, Irene L Llorente, David J DiTullio, Michal Machnicki, Harry V Vinters, Lief A Havton, Roman J Giger, Jason D Hinman, S Thomas Carmichael
White matter stroke is a distinct stroke subtype, accounting for up to 25% of stroke and constituting the second leading cause of dementia. The biology of possible tissue repair after white matter stroke has not been determined. In a mouse stroke model, white matter ischemia causes focal damage and adjacent areas of axonal myelin disruption and gliosis. In these areas of only partial damage, local white matter progenitors respond to injury, as oligodendrocyte progenitors (OPCs) proliferate. However, OPCs fail to mature into oligodendrocytes (OLs) even in regions of demyelination with intact axons and instead divert into an astrocytic fate...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27874947/the-relationship-between-the-occurrence-of-intractable-epilepsy-with-glial-cells-and-myelin-sheath-an-experimental-study
#7
X Hu, J-Y Wang, R Gu, H Qu, M Li, L Chen, R Liu, P Yuan
OBJECTIVE: The occurrence of epilepsy is associated with myelin sheath injury; oligodendrocyte (OL) is the main cell of myelin sheath; In this study, we observed the changes of OL, demyelination, and myelin associated protein in different stages of intractable epilepsy (IE) at the epileptic foci of patients, and provide useful information for the pathophysiology of IE. PATIENTS AND METHODS: IE patients who received epileptogenic focus resection were recruited as the experimental group, their medical records were collected and postoperative follow-up was performed...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27867470/effect-of-sevoflurane-anesthesia-on-the-comprehensive-mrna-expression-profile-of-the-mouse-hippocampus
#8
Tomo Hayase, Shunsuke Tachibana, Michiaki Yamakage
Postoperative nausea and vomiting (PONV) is a common complication after general anesthesia. Recent studies suggested that the hippocampus is involved in PONV. Hypothesising that hippocampal dopaminergic neurons are related to PONV, we examined the comprehensive mRNA profile of the hippocampus, using a sevoflurane-treated mouse model to confirm this. This study was conducted after approval from our institutional animal ethics committee, the Animal Research Center of Sapporo Medical University School of Medicine (project number: 12-033)...
April 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27798181/nogo-receptor-1-confines-a-disinhibitory-microcircuit-to-the-critical-period-in-visual-cortex
#9
Céleste-Élise Stephany, Taruna Ikrar, Collins Nguyen, Xiangmin Xu, Aaron W McGee
: A characteristic of the developing mammalian visual system is a brief interval of plasticity, termed the "critical period," when the circuitry of primary visual cortex is most sensitive to perturbation of visual experience. Depriving one eye of vision (monocular deprivation [MD]) during the critical period alters ocular dominance (OD) by shifting the responsiveness of neurons in visual cortex to favor the nondeprived eye. A disinhibitory microcircuit involving parvalbumin-expressing (PV) interneurons initiates this OD plasticity...
October 26, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27761788/overexpression-of-tau-rescues-nogo-66-induced-neurite-outgrowth-inhibition-in-vitro
#10
Yu-Chao Zuo, Hong-Lian Li, Nan-Xiang Xiong, Jian-Ying Shen, Yi-Zhi Huang, Peng Fu, Hong-Yang Zhao
Nogo-66 plays a central role in the myelin-mediated inhibition of neurite outgrowth. Tau is a microtubule-associated protein involved in microtubule assembly and stabilization. It remains unverified whether tau interacts directly with growth factor receptors, or engages in cross-talk with regeneration inhibitors like Nogo-66. Here, we report that plasmid overexpression of tau significantly elevated the protein levels of total tau, phosphorylated tau, and microtubule-affinity regulating kinase (MARK). Nogo-66 transiently elevated the total tau protein level and persistently reduced the level of p-S262 tau (tau phosphorylated at serine 262), whereas it had little influence on the level of p-T205 tau (tau phosphorylated at threonine 205)...
December 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27751227/-neuroprotective-effect-of-nogo-66-receptor-silencing-in-preterm-rats-with-brain-injury-caused-by-intrauterine-infection
#11
Shi-Fa Zhang, Yan Zhou, Kai-Jing Zhang, Jia-Jie Luan, Shi-Mei Qi
OBJECTIVE: To investigate the effect of Nogo-66 receptor (NgR) silencing with specific small interfering RNA (siRNA) on brain injury repair in preterm rats with brain injury caused by intrauterine infection and related mechanism of action. METHODS: The pregnant Sprague-Dawley rats (with a gestational age of 15 days) were selected, and premature delivery was induced by RU486 or lipopolysaccharide (LPS). The preterm rats delivered by those treated with RU486 were selected as the control group...
October 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27728768/in-depth-cerebrospinal-fluid-quantitative-proteome-and-deglycoproteome-analysis-presenting-a-comprehensive-picture-of-pathways-and-processes-affected-by-multiple-sclerosis
#12
Ann Cathrine Kroksveen, Astrid Guldbrandsen, Marc Vaudel, Ragnhild Reehorst Lereim, Harald Barsnes, Kjell-Morten Myhr, Øyvind Torkildsen, Frode S Berven
In the current study, we conducted a quantitative in-depth proteome and deglycoproteome analysis of cerebrospinal fluid (CSF) from relapsing-remitting multiple sclerosis (RRMS) and neurological controls using mass spectrometry and pathway analysis. More than 2000 proteins and 1700 deglycopeptides were quantified, with 484 proteins and 180 deglycopeptides significantly changed between pools of RRMS and pools of controls. Approximately 300 of the significantly changed proteins were assigned to various biological processes, including inflammation, extracellular matrix organization, cell adhesion, immune response and neuron development...
October 11, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27724971/nogo-receptor-complex-expression-dynamics-in-the-inflammatory-foci-of-central-nervous-system-experimental-autoimmune-demyelination
#13
Paschalis Theotokis, Olga Touloumi, Roza Lagoudaki, Evangelia Nousiopoulou, Evangelia Kesidou, Spyridon Siafis, Theodoros Tselios, Athanasios Lourbopoulos, Dimitrios Karacostas, Nikolaos Grigoriadis, Constantina Simeonidou
BACKGROUND: Nogo-A and its putative receptor NgR are considered to be among the inhibitors of axonal regeneration in the CNS. However, few studies so far have addressed the issue of local NgR complex multilateral localization within inflammation in an MS mouse model of autoimmune demyelination. METHODS: Chronic experimental autoimmune encephalomyelitis (EAE) was induced in C57BL/6 mice. Analyses were performed on acute (days 18-22) and chronic (day 50) time points and compared to controls...
October 11, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27616630/nogo-a-does-not-inhibit-retinal-axon-regeneration-in-the-lizard-gallotia-galloti
#14
Dirk M Lang, Maria Del Mar Romero-Alemán, Bryony Dobson, Elena Santos, Maximina Monzón-Mayor
The myelin-associated protein Nogo-A contributes to the failure of axon regeneration in the mammalian central nervous system (CNS). Inhibition of axon growth by Nogo-A is mediated by the Nogo-66 receptor (NgR). Nonmammalian vertebrates, however, are capable of spontaneous CNS axon regeneration, and we have shown that retinal ganglion cell (RGC) axons regenerate in the lizard Gallotia galloti. Using immunohistochemistry, we observed spatiotemporal regulation of Nogo-A and NgR in cell bodies and axons of RGCs during ontogeny...
October 6, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27611089/the-neurite-outgrowth-inhibitory-nogo-a-%C3%AE-20-region-is-an-intrinsically-disordered-segment-harbouring-three-stretches-with-helical-propensity
#15
Viviane Zelenay, Michael E Arzt, Stefan Bibow, Martin E Schwab, Roland Riek
Functional recovery from central neurotrauma, such as spinal cord injury, is limited by myelin-associated inhibitory proteins. The most prominent example, Nogo-A, imposes an inhibitory cue for nerve fibre growth via two independent domains: Nogo-A-Δ20 (residues 544-725 of the rat Nogo-A sequence) and Nogo-66 (residues 1026-1091). Inhibitory signalling from these domains causes a collapse of the neuronal growth cone via individual receptor complexes, centred around sphingosine 1-phosphate receptor 2 (S1PR2) for Nogo-A-Δ20 and Nogo receptor 1 (NgR1) for Nogo-66...
2016: PloS One
https://www.readbyqxmd.com/read/27578914/nogo-receptor-1-is-expressed-in-both-primary-cultured-glial-cells-and-neurons
#16
Junichi Ukai, Shiro Imagama, Tomohiro Ohgomori, Zenya Ito, Kei Ando, Naoki Ishiguro, Kenji Kadomatsu
Nogo receptor (NgR) is common in myelin-derived molecules, i.e., Nogo, MAG, and OMgp, and plays important roles in both axon fasciculation and the inhibition of axonal regeneration. In contrast to NgR's roles in neurons, its roles in glial cells have been poorly explored. Here, we found a dynamic regulation of NgR1 expression during development and neuronal injury. NgR1 mRNA was consistently expressed in the brain from embryonic day 18 to postnatal day 25. In contrast, its expression significantly decreased in the spinal cord during development...
August 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/27354599/prognostic-significance-of-nogo-a-b-and-nogo-b-receptor-expression-in-malignant-melanoma-a-preliminary-study
#17
Jacek Calik, Bartosz Pula, Aleksandra Piotrowska, Andrzej Wojnar, Wojciech Witkiewicz, Jedrzej Grzegrzolka, Marzena Podhorska-Okolow, Piotr Dziegiel
BACKGROUND: Neurite outgrowth inhibitor type B (NOGO-B) and its receptor (NGBR) were shown to regulate various crucial cellular processes and may be therefore potential factors influencing carcinogenesis. MATERIALS AND METHODS: Expression of NOGO-A, NOGO-A/B and NGBR was studied in benign melanocytic lesions and primary tumors and metastases of malignant melanoma (MM). RESULTS: Cytoplasmic expression of the studied antigens was detected in melanocytes and MM cells...
July 2016: Anticancer Research
https://www.readbyqxmd.com/read/27353365/the-er-structural-protein-rtn4a-stabilizes-and-enhances-signaling-through-the-receptor-tyrosine-kinase-erbb3
#18
Jason Hatakeyama, Jessica H Wald, Hanine Rafidi, Antonio Cuevas, Colleen Sweeney, Kermit L Carraway
ErbB3 and ErbB4 are receptor tyrosine kinases that are activated by the neuregulin (NRG) family of growth factors. These receptors govern various developmental processes, and their dysregulation contributes to several human disease states. The abundance of ErbB3 and ErbB4, and thus signaling through these receptors, is limited by the E3 ubiquitin ligase Nrdp1, which targets ErbB3 and ErbB4 for degradation. Reticulons are proteins that influence the morphology of the endoplasmic reticulum (ER) by promoting the formation of tubules, a response of cells to some stressors...
2016: Science Signaling
https://www.readbyqxmd.com/read/27349794/nogo-a-regulates-spatial-learning-as-well-as-memory-formation-and-modulates-structural-plasticity-in-the-adult-mouse-hippocampus
#19
Marta Zagrebelsky, Niklas Lonnemann, Steffen Fricke, Yves Kellner, Eike Preuß, Kristin Michaelsen-Preusse, Martin Korte
Behavioral learning has been shown to involve changes in the function and structure of synaptic connections of the central nervous system (CNS). On the other hand, the neuronal circuitry in the mature brain is characterized by a high degree of stability possibly providing a correlate for long-term storage of information. This observation indicates the requirement for a set of molecules inhibiting plasticity and promoting stability thereby providing temporal and spatial specificity to plastic processes. Indeed, signaling of Nogo-A via its receptors has been shown to play a crucial role in restricting activity-dependent functional and structural plasticity in the adult CNS...
June 24, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27339102/agenesis-of-the-corpus-callosum-in-nogo-receptor-deficient-mice
#20
Seung-Wan Yoo, Mary G Motari, Ronald L Schnaar
The corpus callosum (CC) is the largest fiber tract in the mammalian brain, linking the bilateral cerebral hemispheres. CC development depends on the proper balance of axon growth cone attractive and repellent cues leading axons to the midline and then directing them to the contralateral hemisphere. Imbalance of these cues results in CC agenesis or dysgenesis. Nogo receptors (NgR1, NgR2, and NgR3) are growth cone directive molecules known for inhibiting axon regeneration after injury. We report that mice lacking Nogo receptors (NgR123-null mice) display complete CC agenesis due to axon misdirection evidenced by ectopic axons including cortical Probst bundles...
February 1, 2017: Journal of Comparative Neurology
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