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https://www.readbyqxmd.com/read/28408340/nogo-a-in-the-visual-system-development-and-in-ocular-diseases
#1
REVIEW
Vincent Pernet
Nogo-A is a potent myelin-associated inhibitor for neuronal growth and plasticity in the central nervous system (CNS). Its effects are mediated by the activation of specific receptors that intracellularly control cytoskeleton rearrangements, protein synthesis and gene expression. Moreover, Nogo-A has been involved in the development of the visual system and in a variety of neurodegenerative diseases and injury processes that can alter its function. For example, Nogo-A was shown to influence optic nerve myelinogenesis, the formation and maturation of retinal axon projections, and retinal angiogenesis...
April 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28344123/effects-of-campylobacter-jejuni-lipopolysaccharide-on-axonal-injury-in-the-spinal-cord-in-rats
#2
Xusheng Li, Haohao Chen, Hongmiao Tao, Ye Hu, Hongqiang Lou
To explore the effects of Campylobacter jejuni lipopolysaccharide (Cj-LPS) on axonal injury in the spinal cord. Wistar rats were divided into the control (NC) group, model group (Cj-LPS), and LPS antibody group (Anti-LPS). Rats in the NC group were injected with a mixture of normal saline and complete Freund's adjuvant (CFA) while those in Cj-LPS group were injected with Cj-LPS, composed of LPS, CFA, and saline. Rats were sacrificed at 4th week and 6th week after injection, and hematoxylin and eosin (HE) staining was performed on the spinal cord sections...
March 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28315758/tat-pep-a-novel-blocker-of-pirb-enhances-the-recovery-of-cognitive-function-in-mice-after-transient-global-cerebral-ischemia
#3
Liya Li, Bin Deng, Shuang Li, Zhaoyu Liu, Tao Jiang, Zhaoyang Xiao, Qiang Wang
Neuronal damage and axonal regeneration inhibition are the main reasons to poor functional recovery after ischemia. Nogo-A signals inhibit axon outgrowth through the PirB receptor after ischemic reperfusion injury in central nervous system. We use TAT-PEP, a novel protein which could pass through the blood brain barrier, to block the function of PirB and identify the long-term neurological and behavioral recovery after bilateral common carotid artery occlusion (BCCAO) in mice. We observed that TAT-PEP promoted neuron survival and inhibited neuronal apoptosis...
March 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28214833/nogo-b-facilitates-lps-mediated-immune-responses-by-up-regulation-of-tlr4-signaling-in-macrophage-raw264-7
#4
Ying Zhu, Qiang Tong, Jia Ye, Yunye Ning, Ye Xiong, Meng Yang, Hua Xiao, Jian Lu, Wujian Xu, Jiandong Li, Qiang Li
BACKGROUND/AIMS: Nogo-B, a member of the reticulon family of proteins, is mainly located in the endoplasmic reticulum (ER). Here, we investigate the function and mechanism of Nogo-B in the regulation of TLR4-associated immune responses in the macrophage cell line of RAW264.7. METHODS: Nogo-B was up- and down-regulated through the use of appropriate adenoviral vectors or siRNA, and the effects of Nogo-B on macrophages under liposaccharide (LPS) stimulation were evaluated via western blotting, immunofluorescence, enzyme-linked immunosorbent assay (ELISA), flow cytometric analysis, and transwell assay...
January 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28193690/lingo-1-regulates-oligodendrocyte-differentiation-through-the-cytoplasmic-gelsolin-signaling-pathway
#5
Zhaohui Shao, Xinhua Lee, Guanrong Huang, Guoqing Sheng, Christopher E Henderson, Daniel Louvard, Jiho Sohn, Blake Pepinsky, Sha Mi
Differentiation and maturation of oligodendrocyte progenitor cells (OPCs) involve the assembly and disassembly of actin microfilaments. How actin dynamics is regulated during this process remains poorly understood. Leucine rich repeat and Immunoglobulin-like domain-containing Nogo receptor interacting protein 1(LINGO-1) is a negative regulator of OPC differentiation. We discovered that anti-LINGO-1 antibody promoted OPC differentiation was accompanied by upregulation of cytoplasmic gelsolin (cGSN), an abundant actin-severing protein involved in the depolymerization of actin filaments...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28110636/roles-of-p75ntr-in-maintaining-brain-hemostasis-and-the-implications-for-p75ntr-targeted-therapies
#6
Changyue Gao, Lili Zhang, Dayu Sun, Jingcheng Li, Xiuqing Yao, Huadong Zhou, Yanjiang Wang
The p75 neurotrophin receptor (p75NTR) is a single membrane-spanning receptor in the tumor necrosis factor (TNF) death domain containing receptor family. p75NTR has multiple faces of biological or pathogenic functions by partnering with the three major neurotrophin receptors, including tropomyosin receptor kinase (Trk), sortilin and Nogo receptors. By partnering with different co-receptors, p75NTR regulates the binding of mature or pro-neurotrophins and activation of different signaling pathways, resulting in outcomes ranging from growth and survival to cell death or apoptosis...
January 10, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28105588/nogo-a-antibodies-for-progressive-multiple-sclerosis
#7
Benjamin V Ineichen, Patricia S Plattner, Nicolas Good, Roland Martin, Michael Linnebank, Martin E Schwab
Most of the current therapies, as well as many of the clinical trials, for multiple sclerosis (MS) target the inflammatory autoimmune processes, but less than 20% of all clinical trials investigate potential therapies for the chronic progressive disease stage of MS. The latter is responsible for the steadily increasing disability in many patients, and there is an urgent need for novel therapies that protect nervous system tissue and enhance axonal growth and/or remyelination. As outlined in this review, solid pre-clinical data suggest neutralization of the neurite outgrowth inhibitor Nogo-A as a potential new way to achieve both axonal and myelin repair...
January 19, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28075461/resistance-of-interleukin-6-to-the-extracellular-inhibitory-environment-promotes-axonal-regeneration-and-functional-recovery-following-spinal-cord-injury
#8
Gang Yang, Wen-Yuan Tang
Interleukin-6 (IL)-6 was originally discovered as a factor that contributes to the secondary pathological and inflammatory response in the central nervous system (CNS) following injury. However, accumulating evidence suggests that IL-6 is also involved in functional and structural recovery following CNS injury by promoting axonal sprou-ting. This suggests a potential dual role of IL-6 in CNS injury. However, the definitive function of IL-6 in neural injury and the corresponding underlying mechanisms are still topics of controversy...
February 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28068323/the-nogo-b-receptor-promotes-ras-plasma-membrane-localization-and-activation
#9
B Zhao, W Hu, S Kumar, P Gonyo, U Rana, Z Liu, B Wang, W Q Duong, Z Yang, C L Williams, Q R Miao
The localization of prenylated Ras at the plasma membrane promotes activation of Ras by receptor tyrosine kinases and stimulates oncogenic signaling by mutant Ras. The Nogo-B receptor (NgBR) is a transmembrane receptor that contains a conserved hydrophobic pocket. Here, we demonstrate that the NgBR promotes the membrane accumulation of Ras by directly binding prenylated Ras at the plasma membrane. We show that NgBR knockdown diminishes the membrane localization of Ras in multiple cell types. NgBR overexpression in NIH-3T3 fibroblasts increases membrane-associated Ras, induces the transformed phenotype in vitro, and promotes the formation of fibrosarcoma in nude mice...
January 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28051106/u24-from-roseolovirus-interacts-strongly-with-nedd4-ww-domains
#10
Yurou Sang, Rui Zhang, Walter R P Scott, A Louise Creagh, Charles A Haynes, Suzana K Straus
U24 is a protein found in both roseoloviruses Human Herpes Virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminus that is rich in prolines (PY motif in both HHV-6A and 7; PxxP motif in HHV-6A). Previous work has shown that the interaction between U24 and WW domains is important for endocytic recycling of T-cell receptors, but a cognate ligand was never identified. In this contribution, data was obtained from pull-downs, ITC, NMR and molecular dynamics simulations to show that a specific interaction exists between U24 and Nedd4 WW domains...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28000762/axonal-branching-in-lateral-olfactory-tract-is-promoted-by-nogo-signaling
#11
Masumi Iketani, Takaakira Yokoyama, Yuji Kurihara, Stephen M Strittmatter, Yoshio Goshima, Nobutaka Kawahara, Kohtaro Takei
Mitral cells are major projection neurons of the olfactory bulb (OB) that form an axonal bundle known as the lateral olfactory tract (LOT). After axonal bundle formation, collateral branches sprout from primary axons of the LOT. Recently, we identified LOT usher substance (LOTUS) as an endogenous Nogo receptor-1 (NgR1) antagonist and demonstrated that LOTUS contributes to the formation of the LOT axonal bundle. Immunoblots revealed that the expression level of Nogo-A in the OB developmentally increased during axonal collateral formation...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27990434/cornel-iridoid-glycoside-improves-locomotor-impairment-and-decreases-spinal-cord-damage-in-rats
#12
Wen-Jing Tang, Deng-Lei Ma, Cui-Cui Yang, Li Zhang, Ya-Li Li, Lan Zhang, Lin Li
Purpose. This study was to investigate the effects of cornel iridoid glycoside (CIG) on spinal cord injury (SCI) in rats. Methods. The thoracic cord (at T9) of rats was injured by clip compression for 30 sec. Locomotor function was assessed using the Basso, Beattie, and Bresnahan (BBB) rating scale. Neuroanatomic stereological parameters as well as Nogo-A, p75 neurotrophin receptor (p75NTR), and ROCKII expression were measured by histological processing, immunohistochemistry, and stereological analyses. The axons passing through the lesion site were detected by BDA tracing...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27956620/nogo-receptor-blockade-overcomes-remyelination-failure-after-white-matter-stroke-and-stimulates-functional-recovery-in-aged-mice
#13
Elif G Sozmen, Shira Rosenzweig, Irene L Llorente, David J DiTullio, Michal Machnicki, Harry V Vinters, Lief A Havton, Roman J Giger, Jason D Hinman, S Thomas Carmichael
White matter stroke is a distinct stroke subtype, accounting for up to 25% of stroke and constituting the second leading cause of dementia. The biology of possible tissue repair after white matter stroke has not been determined. In a mouse stroke model, white matter ischemia causes focal damage and adjacent areas of axonal myelin disruption and gliosis. In these areas of only partial damage, local white matter progenitors respond to injury, as oligodendrocyte progenitors (OPCs) proliferate. However, OPCs fail to mature into oligodendrocytes (OLs) even in regions of demyelination with intact axons and instead divert into an astrocytic fate...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27874947/the-relationship-between-the-occurrence-of-intractable-epilepsy-with-glial-cells-and-myelin-sheath-an-experimental-study
#14
X Hu, J-Y Wang, R Gu, H Qu, M Li, L Chen, R Liu, P Yuan
OBJECTIVE: The occurrence of epilepsy is associated with myelin sheath injury; oligodendrocyte (OL) is the main cell of myelin sheath; In this study, we observed the changes of OL, demyelination, and myelin associated protein in different stages of intractable epilepsy (IE) at the epileptic foci of patients, and provide useful information for the pathophysiology of IE. PATIENTS AND METHODS: IE patients who received epileptogenic focus resection were recruited as the experimental group, their medical records were collected and postoperative follow-up was performed...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27867470/effect-of-sevoflurane-anesthesia-on-the-comprehensive-mrna-expression-profile-of-the-mouse-hippocampus
#15
Tomo Hayase, Shunsuke Tachibana, Michiaki Yamakage
Postoperative nausea and vomiting (PONV) is a common complication after general anesthesia. Recent studies suggested that the hippocampus is involved in PONV. Hypothesising that hippocampal dopaminergic neurons are related to PONV, we examined the comprehensive mRNA profile of the hippocampus, using a sevoflurane-treated mouse model to confirm this. This study was conducted after approval from our institutional animal ethics committee, the Animal Research Center of Sapporo Medical University School of Medicine (project number: 12-033)...
April 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27798181/nogo-receptor-1-confines-a-disinhibitory-microcircuit-to-the-critical-period-in-visual-cortex
#16
Céleste-Élise Stephany, Taruna Ikrar, Collins Nguyen, Xiangmin Xu, Aaron W McGee
A characteristic of the developing mammalian visual system is a brief interval of plasticity, termed the "critical period," when the circuitry of primary visual cortex is most sensitive to perturbation of visual experience. Depriving one eye of vision (monocular deprivation [MD]) during the critical period alters ocular dominance (OD) by shifting the responsiveness of neurons in visual cortex to favor the nondeprived eye. A disinhibitory microcircuit involving parvalbumin-expressing (PV) interneurons initiates this OD plasticity...
October 26, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27761788/overexpression-of-tau-rescues-nogo-66-induced-neurite-outgrowth-inhibition-in-vitro
#17
Yu-Chao Zuo, Hong-Lian Li, Nan-Xiang Xiong, Jian-Ying Shen, Yi-Zhi Huang, Peng Fu, Hong-Yang Zhao
Nogo-66 plays a central role in the myelin-mediated inhibition of neurite outgrowth. Tau is a microtubule-associated protein involved in microtubule assembly and stabilization. It remains unverified whether tau interacts directly with growth factor receptors, or engages in cross-talk with regeneration inhibitors like Nogo-66. Here, we report that plasmid overexpression of tau significantly elevated the protein levels of total tau, phosphorylated tau, and microtubule-affinity regulating kinase (MARK). Nogo-66 transiently elevated the total tau protein level and persistently reduced the level of p-S262 tau (tau phosphorylated at serine 262), whereas it had little influence on the level of p-T205 tau (tau phosphorylated at threonine 205)...
December 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27751227/-neuroprotective-effect-of-nogo-66-receptor-silencing-in-preterm-rats-with-brain-injury-caused-by-intrauterine-infection
#18
Shi-Fa Zhang, Yan Zhou, Kai-Jing Zhang, Jia-Jie Luan, Shi-Mei Qi
OBJECTIVE: To investigate the effect of Nogo-66 receptor (NgR) silencing with specific small interfering RNA (siRNA) on brain injury repair in preterm rats with brain injury caused by intrauterine infection and related mechanism of action. METHODS: The pregnant Sprague-Dawley rats (with a gestational age of 15 days) were selected, and premature delivery was induced by RU486 or lipopolysaccharide (LPS). The preterm rats delivered by those treated with RU486 were selected as the control group...
October 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27728768/in-depth-cerebrospinal-fluid-quantitative-proteome-and-deglycoproteome-analysis-presenting-a-comprehensive-picture-of-pathways-and-processes-affected-by-multiple-sclerosis
#19
Ann Cathrine Kroksveen, Astrid Guldbrandsen, Marc Vaudel, Ragnhild Reehorst Lereim, Harald Barsnes, Kjell-Morten Myhr, Øyvind Torkildsen, Frode S Berven
In the current study, we conducted a quantitative in-depth proteome and deglycoproteome analysis of cerebrospinal fluid (CSF) from relapsing-remitting multiple sclerosis (RRMS) and neurological controls using mass spectrometry and pathway analysis. More than 2000 proteins and 1700 deglycopeptides were quantified, with 484 proteins and 180 deglycopeptides significantly changed between pools of RRMS and pools of controls. Approximately 300 of the significantly changed proteins were assigned to various biological processes, including inflammation, extracellular matrix organization, cell adhesion, immune response and neuron development...
October 11, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27724971/nogo-receptor-complex-expression-dynamics-in-the-inflammatory-foci-of-central-nervous-system-experimental-autoimmune-demyelination
#20
Paschalis Theotokis, Olga Touloumi, Roza Lagoudaki, Evangelia Nousiopoulou, Evangelia Kesidou, Spyridon Siafis, Theodoros Tselios, Athanasios Lourbopoulos, Dimitrios Karacostas, Nikolaos Grigoriadis, Constantina Simeonidou
BACKGROUND: Nogo-A and its putative receptor NgR are considered to be among the inhibitors of axonal regeneration in the CNS. However, few studies so far have addressed the issue of local NgR complex multilateral localization within inflammation in an MS mouse model of autoimmune demyelination. METHODS: Chronic experimental autoimmune encephalomyelitis (EAE) was induced in C57BL/6 mice. Analyses were performed on acute (days 18-22) and chronic (day 50) time points and compared to controls...
October 11, 2016: Journal of Neuroinflammation
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