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https://www.readbyqxmd.com/read/27914945/effects-of-zacopride-a-moderate-ik1-channel-agonist-on-triggered-arrhythmia-and-contractility-in-human-ventricular-myocardium
#1
Mohammad T Elnakish, Benjamin D Canan, Ahmet Kilic, Peter J Mohler, Paul M L Janssen
Ventricular tachycardia is the leading cause of sudden arrhythmic death in the U.S. Recently, the moderate IK1 channel activator, zacopride, was shown to suppress triggered ventricular tachycardia in rats. Nonetheless, concerns were raised about the possibility of pro-arrhythmic activity after IK1 channel stimulation based on the promising anti-arrhythmic strategy of IK1 blockade in other animal models. Therefore, the goal of the current study was to investigate the ex-vivo effects of zacopride on triggered arrhythmia and contractility in ventricular human myocardium in order to validate data that was solely obtained from animal models...
November 30, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27888834/exploring-the-impact-of-word-of-mouth-about-physicians-service-quality-on-patient-choice-based-on-online-health-communities
#2
Naiji Lu, Hong Wu
BACKGROUND: Health care service is a high-credence service and patients may face difficulties ascertaining service quality in order to make choices about their available treatment options. Online health communities (OHCs) provide a convenient channel for patients to search for physicians' information, such as Word-of-Mouth (WOM), particularly on physicians' service quality evaluated by other patients. Existing studies from other service domains have proved that WOM impacts consumer choice...
November 26, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27888100/harnessing-wharton-s-jelly-stem-cell-differentiation-into-bone-like-nodule-on-calcium-phosphate-substrate-without-osteoinductive-factors
#3
S Mechiche Alami, H Rammal, C Boulagnon-Rombi, F Velard, F Lazar, R Drevet, D Laurent Maquin, S C Gangloff, J Hemmerlé, J C Voegel, G Francius, P Schaaf, F Boulmedais, H Kerdjoudj
: An important aim of bone regenerative medicine is to design biomaterials with controlled chemical and topographical features to guide stem cell fate towards osteoblasts without addition of specific osteogenic factors. Herein, we find that sprayed bioactive and biocompatible calcium phosphate substrates (CaP) with controlled topography induce, in a well-orchestrated manner, Wharton's jelly stem cells (WJ-SCs) differentiation into osteoblastic lineage without any osteogenic supplements...
November 22, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27738255/feasibility-of-conducting-prospective-observational-research-on-critically-ill-dying-patients-in-the-intensive-care-unit
#4
Amanda van Beinum, Laura Hornby, Sonny Dhanani, Roxanne Ward, Jane Chambers-Evans, Kusum Menon
Studying patients during the end of life is important, as it has the potential to lead to improvements in care for the dying. For patients who die after a controlled withdrawal of life-sustaining therapies in the intensive care unit, information about the natural history of death and the process of removing life support has additionally led to advances in practice for deceased organ donation. However, this unique population of severely critically ill and imminently dying patients has been difficult to study, largely due to assumptions made by research teams and ethics boards alike about the logistical difficulties of obtaining consent and completing research procedures before or during the process of withdrawal of life-sustaining therapies...
October 13, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27651301/assessing-changes-in-a-patient-s-condition%C3%A2-%C3%A2-perspectives-of-intensive-care-nurses
#5
Monica Kvande, Charlotte Delmar, Else Lykkeslet, Sissel Lisa Storli
AIM: To explore the phenomenon of assessing changes in patients' conditions in intensive care units from the perspectives of experienced intensive care nurses. BACKGROUND: Providing safe care for patients in intensive care units requires an awareness and perception of the signs that indicate changes in a patient's condition. Nurses in intensive care units play an essential role in preventing the deterioration of a patient's condition and in improving patient outcomes...
September 21, 2016: Nursing in Critical Care
https://www.readbyqxmd.com/read/27553804/compliance-of-the-abdominal-wall-during-laparoscopic-insufflation
#6
Chuck Becker, Margaret A Plymale, John Wennergren, Crystal Totten, Kyle Stigall, J Scott Roth
BACKGROUND: To provide adequate workspace between the viscera and abdominal wall, insufflation with carbon dioxide is a common practice in laparoscopic surgeries. An insufflation pressure of 15 mmHg is considered to be safe in patients, but all insufflation pressures create perioperative and postoperative physiologic effects. As a composition of viscoelastic materials, the abdominal wall should distend in a predictable manner given the pressure of the pneumoperitoneum. The purpose of this study was to elucidate the relationship between degree of abdominal distention and the insufflation pressure, with the goal of determining factors which impact the compliance of the abdominal wall...
August 23, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27529030/clinically-integrated-multi-organ-point-of-care-ultrasound-for-undifferentiated-respiratory-difficulty-chest-pain-or-shock-a-critical-analytic-review
#7
REVIEW
Young-Rock Ha, Hong-Chuen Toh
Rapid and accurate diagnosis and treatment are paramount in the management of the critically ill. Critical care ultrasound has been widely used as an adjunct to standard clinical examination, an invaluable extension of physical examination to guide clinical decision-making at bedside. Recently, there is growing interest in the use of multi-organ point-of-care ultrasound (MOPOCUS) for the management of the critically ill, especially in the early phase of resuscitation. This article will review the role and utility of symptom-based and sign-oriented MOPOCUS in patients with undifferentiated respiratory difficulty, chest pain, or shock and how it can be performed in a timely, effective, and efficient manner...
2016: Journal of Intensive Care
https://www.readbyqxmd.com/read/27437048/guiding-principles-for-a-pediatric-neurology-icu-neuropicu-bedside-multimodal-monitor-findings-from-an-international-working-group
#8
Zachary M Grinspan, Yonina C Eldar, Daniel Gopher, Amihai Gottlieb, Rotem Lammfromm, Halinder S Mangat, Nimrod Peleg, Steven Pon, Igal Rozenberg, Nicholas D Schiff, David E Stark, Peter Yan, Hillel Pratt, Barry E Kosofsky
BACKGROUND: Physicians caring for children with serious acute neurologic disease must process overwhelming amounts of physiological and medical information. Strategies to optimize real time display of this information are understudied. OBJECTIVES: Our goal was to engage clinical and engineering experts to develop guiding principles for creating a pediatric neurology intensive care unit (neuroPICU) monitor that integrates and displays data from multiple sources in an intuitive and informative manner...
2016: Applied Clinical Informatics
https://www.readbyqxmd.com/read/27315070/-cardiac-hemodynamics-during-shock-management-in-daily-clinical-routine
#9
A Kersten
In caring for critically ill patients, a sophisticated approach to treating hemodynamic instability in acute circulatory failure is a major concern of modern critical care. Depending on the form of shock-distributive, cardiogenic, hypovolemic or obstructive, with the possibility of overlapping forms of shock-preload, afterload, cardiac output, and contractility are altered in various ways. Modern critical care uses hemodynamic monitoring and bedside echocardiography in addition to clinical evaluation to treat the underlying cause and sequelae of shock...
June 17, 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/27298147/the-association-between-delays-in-screening-for-and-assessing-dysphagia-after-acute-stroke-and-the-risk-of-stroke-associated-pneumonia
#10
Benjamin D Bray, Craig J Smith, Geoffrey C Cloud, Pam Enderby, Martin James, Lizz Paley, Pippa J Tyrrell, Charles D A Wolfe, Anthony G Rudd
BACKGROUND: There is no robust evidence that screening patients with acute stroke for dysphagia reduces the risk of stroke-associated pneumonia (SAP), or of how quickly it should be done after admission. We aimed to identify if delays in bedside dysphagia screening and comprehensive dysphagia assessments by a speech and language therapist (SALT) were associated with patients' risk of SAP. METHODS: Nationwide, registry-based, prospective cohort study of patients admitted with acute stroke in England and Wales...
June 13, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27274747/whole-genome-sequencing-as-a-genetic-test-for-autism-spectrum-disorder-from-bench-to-bedside-and-then-back-again
#11
Michael J Szego, Ma'n H Zawati
Autism spectrum disorder (ASD) is characterized by repetitive patterns of behaviour and impairments in social interactions and communication abilities. Although ASD is a heterogeneous disorder, it is a highly genetic condition for which genetic testing is routinely performed. Microarray analysis is currently the standard of care genetic test for ASD, however whole genome sequencing offers several key advantages and will likely replace microarrays as a frontline genetic test in the near future. The 2nd Consultation on Translation of Genomic Advances into Health Applications took place in the spring of 2014 to broadly explore the current and potential impacts of genomic advances in supporting personalized and family-centered care for autism and related developmental conditions...
2016: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27215922/measurement-of-inflammation-in-eosinophilic-esophagitis-using-an-eosinophil-peroxidase-assay
#12
Hedieh Saffari, Kristin M Leiferman, Frederic Clayton, Krista Baer, Leonard F Iii Pease, Gerald J Gleich, Kathryn A Peterson
OBJECTIVES: We describe a simple, quick method to measure an eosinophil granule protein, eosinophil peroxidase (EPO), as a marker of eosinophil activity, in eosinophilic esophagitis (EoE). METHODS: Esophageal mucosal brushings initially were collected from 36 patients with active EoE (n=13), resolved EoE (n=13), and controls (n=10) before endoscopic biopsy collection; the brushes were frozen at -80 ºC until assayed. EPO on the brush was measured in a colorimetric assay visually and by spectrophotometric absorbance measurements (at 492 nm), and was compared with peak eosinophil counts in esophageal biopsy specimens...
July 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27176121/portable-video-media-versus-standard-verbal-communication-in-surgical-information-delivery-to-nurses-a-prospective-multicenter-randomized-controlled-crossover-trial
#13
Jonathan Kam, Hannah Ainsworth, Marcus Handmer, Mark Louie-Johnsun, Matthew Winter
BACKGROUND: Continuing education of health professionals is important for delivery of quality health care. Surgical nurses are often required to understand surgical procedures. Nurses need to be aware of the expected outcomes and recognize potential complications of such procedures during their daily work. Traditional educational methods, such as conferences and tutorials or informal education at the bedside, have many drawbacks for delivery of this information in a universal, standardized, and timely manner...
October 2016: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/27168272/urea-a-clinically-oriented-overview-from-bench-to-bedside
#14
Adam J Friedman, Erika C von Grote, Matthew H Meckfessel
Urea is an important hygroscopic component of the epidermis, where it participates in the maintenance of skin hydration as part of the skin's source of natural moisturizing factor (NMF) in the outer most layers. Xerotic skin, which is frequently characterized as NMF-deficient, is a unifying trait of dermatoses such as atopic dermatitis (AD), psoriasis, and ichthyosis vulgaris. The reduced hygroscopic potential of pathologically dry skin leads to unregulated transepidermal water loss (TEWL), epidermal hyperproliferation, and inhibited desquamation; all which clinically translate to hyperkeratotic and possibly pruritic skin...
May 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27167097/a-qualitative-analysis-of-patients-experience-with-hospitalist-service-handovers
#15
Charlie M Wray, Jeanne M Farnan, Vineet M Arora, David O Meltzer
BACKGROUND: Inpatient service handoffs occur when physicians who care for hospitalized patients end a period of clinical service and handover a panel of patients to an oncoming physician. Despite the large amount of research on handoffs, none has described the patient perspective when cared for by a hospitalist physician during a service handoff. OBJECTIVE: To describe hospitalized patients' experiences regarding inpatient service changes, and develop a conceptual framework to inform future efforts to improve service-level handoffs...
May 11, 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/27165558/the-voice-of-chinese-health-consumers-a-text-mining-approach-to-web-based-physician-reviews
#16
Haijing Hao, Kunpeng Zhang
BACKGROUND: Many Web-based health care platforms allow patients to evaluate physicians by posting open-end textual reviews based on their experiences. These reviews are helpful resources for other patients to choose high-quality doctors, especially in countries like China where no doctor referral systems exist. Analyzing such a large amount of user-generated content to understand the voice of health consumers has attracted much attention from health care providers and health care researchers...
2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27146335/medical-students-perceptions-of-bedside-teaching
#17
David Gray, Octavian Cozar, Janet Lefroy
BACKGROUND: Bedside teaching is recognised as a valuable tool in medical education by both students and faculty members. Bedside teaching is frequently delivered by consultants; however, junior doctors are increasingly engaging in this form of clinical teaching, and their value in this respect is becoming more widely recognised. The aim of this study was to supplement work completed by previous authors who have begun to explore students' satisfaction with bedside teaching, and their perceptions of the relationship with the clinical teachers...
May 4, 2016: Clinical Teacher
https://www.readbyqxmd.com/read/27142860/a-balancing-act-a-phenomenological-exploration-of-medical-students-experiences-of-using-mobile-devices-in-the-clinical-setting
#18
F Rashid-Doubell, S Mohamed, K Elmusharaf, C S O'Neill
OBJECTIVE: The aims of this study were to describe the experiences of senior students using mobile devices in a clinical setting while learning and interacting with clinical teachers, patients and each other, and to identify challenges that facilitated or impeded the use of such devices in the hospital. DESIGN: Interpretative phenomenology was chosen to guide our enquiry. Semi-structured interviews were conducted to examine the experiences of five senior medical students using mobile devices in the clinical setting...
2016: BMJ Open
https://www.readbyqxmd.com/read/27134226/underestimation-of-pupil-size-by-critical-care-and-neurosurgical-nurses
#19
Robert G Kerr, Andrea M Bacon, Laura L Baker, Janelle S Gehrke, K Danielle Hahn, Cheryl L Lillegraven, Catherine Hackett Renner, Sarah K Spilman
BACKGROUND: Early detection of pupillary changes in patients with head injuries can alert the care team to increasing intracranial pressure. Previous research has shown inconsistencies in pupil measurement that are most likely due to the subjective nature of measuring pupils without the assistance of technology. OBJECTIVES: To evaluate nurses' abilities to assess pupil diameter accurately and detect unequal pupils. METHODS: In a 3-part study, the accuracy of critical care and neurosurgical nurses' assessments of pupils was determined...
May 2016: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/27125015/diagnostic-emergency-ultrasound-assessment-techniques-in-the-pediatric-patient
#20
REVIEW
Joshua Guttman, Bret P Nelson
Emergency ultrasound is performed at the point of care to answer focused clinical questions in a rapid manner. Over the last 20 years, the use of this technique has grown rapidly, and it has become a core requirement in many emergency medicine residencies and in some pediatric emergency medicine fellowships. The use of emergency ultrasound in the pediatric setting is increasing due to the lack of ionizing radiation with these studies, as compared to computed tomography. Utilizing diagnostic ultrasound in the emergency department can allow clinicians to arrive at a diagnosis at the bedside rather than sending the patient out of the department for another study...
January 2016: Pediatric Emergency Medicine Practice
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