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https://www.readbyqxmd.com/read/29771911/asymmetric-polar-localization-dynamics-of-the-serine-chemoreceptor-protein-tsr-in-escherichia-coli
#1
Dongmyung Oh, Yang Yu, Hochan Lee, Jae-Hyung Jeon, Barry L Wanner, Ken Ritchie
The spatial location of proteins in living cells can be critical for their function. For example, the E. coli chemotaxis machinery is localized to the cell poles. Here we describe the polar localization of the serine chemoreceptor Tsr using a strain synthesizing a fluorescent Tsr-Venus fusion at a low level from a single-copy chromosomal construct. Using photobleaching and imaging during recovery by new synthesis, we observed distinct asymmetry between a bright (old) pole and a dim (new) pole. The old pole was shown to be a more stable cluster and to recover after photobleaching faster, which is consistent with the hypothesis that newly synthesized Tsr proteins are inserted directly at or near the old pole...
2018: PloS One
https://www.readbyqxmd.com/read/29770464/chemically-characterised-extract-of-saraca-asoca-improves-the-sexual-function-in-male-wistar-rats
#2
M Gill, A Rai, M Kinra, S Sumalatha, C M Rao, S P Cheruku, R Devkar, N Kumar
In this study, methanolic extract of Saraca asoca bark was evaluated for its aphrodisiac potential using male and female Wistar albino rats. Male rats were dosed daily for 54 days at a dose of 100 mg/kg p.o. Sexual activity of male rats was assessed after 14, 28, 42 and 54 days of the study. Male rats were placed in a glass chamber lit with a dim red light (10W) followed by the introduction of sexually receptive female rats in a ratio of 1:1. Improvement in sexual behaviour of male rats was characterised by an increase in both mount frequency and intromission frequency and decrease or reduction in mount latency and intromission latency compared to normal control...
May 16, 2018: Andrologia
https://www.readbyqxmd.com/read/29764618/investigating-daily-fatigue-scores-during-two-week-offshore-day-shifts
#3
Vanessa Riethmeister, Ute Bültmann, Marijke Gordijn, Sandra Brouwer, Michiel de Boer
OBJECTIVES: This study examined daily scores of fatigue and circadian rhythm markers over two-week offshore day shift periods. METHODS: A prospective cohort study among N = 60 offshore day-shift workers working two-week offshore shifts was conducted. Offshore day shifts lasted from 07:00 - 19:00 h. Fatigue was measured objectively with pre- and post-shift scores of the 3-minute psychomotor vigilance tasks (PVT-B) parameters (reaction times, number of lapses, errors and false starts) and subjectively with pre- and post-shift Karolinska Sleepiness Scale (KSS) ratings...
September 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29763583/m%C3%A3-ller-glial-cells-contribute-to-dim-light-vision-in-the-spectacled-caiman-caiman-crocodilus-fuscus-analysis-of-retinal-light-transmission
#4
Silke Agte, Alexey Savvinov, Anett Karl, Astrid Zayas-Santiago, Elke Ulbricht, Vladimir I Makarov, Andreas Reichenbach, Andreas Bringmann, Serguei N Skatchkov
In this study, we show the capability of Müller glial cells to transport light through the inverted retina of reptiles, specifically the retina of the spectacled caimans. Thus, confirming that Müller cells of lower vertebrates also improve retinal light transmission. Confocal imaging of freshly isolated retinal wholemounts, that preserved the refractive index landscape of the tissue, indicated that the retina of the spectacled caiman is adapted for vision under dim light conditions. For light transmission experiments, we used a setup with two axially aligned objectives imaging the retina from both sides to project the light onto the inner (vitreal) surface and to detect the transmitted light behind the retina at the receptor layer...
May 12, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29759093/validation-of-a-novel-image-weighed-technique-for-monitoring-food-intake-and-estimation-of-portion-size-in-hospital-settings-a-pilot-study
#5
Kwabena T Ofei, Bent E Mikkelsen, Rudolf A Scheller
OBJECTIVE: Optimal nutrition for hospital patients is crucial and routine monitoring of patients' nutrient intake is imperative. However, personalised monitoring and customised intervention using traditional methods is challenging and labour-intensive, consequently it is often neglected in hospital settings. The present pilot study aimed to examine the reliability and validity of the Dietary Intake Monitoring System (DIMS) against the weighed food method (WFM). DESIGN: The DIMS 2...
May 15, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29755462/comparison-of-phenotypic-and-functional-characteristics-between-canine-non-b-non-t-natural-killer-lymphocytes-and-cd3-cd5-dim-cd21-cytotoxic-large-granular-lymphocytes
#6
Soo-Hyeon Lee, Dong-Jun Shin, Yoseop Kim, Cheol-Jung Kim, Je-Jung Lee, Mee Sun Yoon, Tung Nguyen Thanh Uong, Dohyeon Yu, Ji-Youn Jung, Duck Cho, Bock-Gie Jung, Sang-Ki Kim, Guk-Hyun Suh
Natural killer (NK) cells play a pivotal role in the immune response against infections and malignant transformation, and adopted transfer of NK cells is thought to be a promising therapeutic approach for cancer patients. Previous reports describing the phenotypic features of canine NK cells have produced inconsistent results. Canine NK cells are still defined as non-B and non-T (CD3- CD21- ) large granular lymphocytes. However, a few reports have demonstrated that canine NK cells share the phenotypic characteristics of T lymphocytes, and that CD3+ CD5dim CD21- lymphocytes are putative canine NK cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29755352/the-problem-of-benzodiazepine-use-and-its-extent-in-the-driver-population-a-population-based-registry-study
#7
Francisco Herrera-Gómez, Eduardo Gutierrez-Abejón, Paloma Criado-Espegel, F Javier Álvarez
Background: Benzodiazepines are driving-impairing medicines (DIM). This study presents current consumption of dispensed benzodiazepines in the Spanish general population, with a focus in pattern of use and concomitant medicines consumed with. Methods: A population-based registry study was carried out to assess the year-2016 granted benzodiazepines dispensation in Castile and León. Weighting was performed to obtain the adjusted benzodiazepine consumption for licensed drivers according to age and gender using our national drivers' license census data...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29753728/retinal-adaptation-to-dim-light-vision-in-spectacled-caimans-caiman-crocodilus-fuscus-analysis-of-retinal-ultrastructure
#8
Anett Karl, Silke Agte, Astrid Zayas-Santiago, Felix N Makarov, Yomarie Rivera, Jan Benedikt, Mike Francke, Andreas Reichenbach, Serguei N Skatchkov, Andreas Bringmann
It has been shown that mammalian retinal glial (Müller) cells act as living optical fibers that guide the light through the retinal tissue to the photoreceptor cells (Agte et al., 2011; Franze et al., 2007). However, for nonmammalian species it is unclear whether Müller cells also improve the transretinal light transmission. Furthermore, for nonmammalian species there is a lack of ultrastructural data of the retinal cells, which, in general, delivers fundamental information of the retinal function, i.e. the vision of the species...
May 10, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29751637/fast-profiling-of-natural-pigments-in-different-spirulina-arthrospira-platensis-dietary-supplements-by-di-ft-icr-and-evaluation-of-their-antioxidant-potential-by-pre-column-dpph-uhplc-assay
#9
Eduardo Sommella, Giulio Maria Conte, Emanuela Salviati, Giacomo Pepe, Alessia Bertamino, Carmine Ostacolo, Francesca Sansone, Francesco Del Prete, Rita Patrizia Aquino, Pietro Campiglia
Arthrospira platensis , better known as Spirulina, is one of the most important microalgae species. This cyanobacterium possesses a rich metabolite pattern, including high amounts of natural pigments. In this study, we applied a combined strategy based on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS) and Ultra High-Performance Liquid Chromatography (UHPLC) for the qualitative/quantitative characterization of Spirulina pigments in three different commercial dietary supplements. FT-ICR was employed to elucidate the qualitative profile of Spirulina pigments, in both direct infusion mode (DIMS) and coupled to UHPLC...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29750598/visual-darkness-reduces-perceived-risk-of-contagious-disease-transmission-from-interpersonal-interaction
#10
Ping Dong, Chen-Bo Zhong
We examined the psychological impact of visual darkness on people's perceived risk of contagious-disease transmission. We posited that darkness triggers an abstract construal level and increases perceived social distance from others, rendering threats from others to seem less relevant to the self. We found that participants staying in a dimly lit room (Studies 1 and 3-5) or wearing sunglasses (Study 2) tended to estimate a lower risk of catching contagious diseases from others than did those staying in a brightly lit room or wearing clear glasses...
May 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29746256/glucocorticoid-receptor-dimers-control-intestinal-stat1-and-tnf-induced-inflammation-in-mice
#11
Marlies Ballegeer, Kelly Van Looveren, Steven Timmermans, Melanie Eggermont, Sofie Vandevyver, Fabien Thery, Karen Dendoncker, Jolien Souffriau, Jolien Vandewalle, Lise Van Wyngene, Riet De Rycke, Nozomi Takahashi, Peter Vandenabeele, Jan Tuckermann, Holger M Reichardt, Francis Impens, Rudi Beyaert, Karolien De Bosscher, Roosmarijn E Vandenbroucke, Claude Libert
Tumor Necrosis Factor (TNF) is an important mediator in numerous inflammatory diseases, e.g., in inflammatory bowel diseases (IBD). In IBD, acute increases in TNF production can lead to disease flares. Glucocorticoids (GCs), which are steroids that bind and activate the glucocorticoid receptor (GR), are able to protect animals and humans against acute TNF-induced inflammatory symptoms. Mice with a poor transcriptional response of GR-dimer-dependent target genes were studied in a model of TNF-induced lethal inflammation...
May 10, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29744624/a-rare-case-of-paediatric-primary-central-nervous-system-lymphoma-treated-with-high-dose-methotrexate-and-rituximab-based-chemoimmunotherapy-and-whole-brain-radiotherapy-followed-by-tumour-bed-boost-with-three-dimensional-conformal-radiation-technique
#12
Narayan Adhikari, Ahitagni Biswas, Sameer Bakhshi, Gaurav Khanna, Vaishali Suri
BACKGROUND: Primary central nervous system lymphomas (PCNSL) are rare in the paediatric population. CLINICAL CASE: A 12-year-old boy presented to our clinic with complaints of multiple episodes of generalised tonic-clonic seizures for 1 year and gradual loss of vision in both eyes for 3 months. Baseline magnetic resonance imaging (MRI) of the brain showed a large (7.2 × 7 cm) enhancing soft tissue lesion in the right frontal lobe causing mass effect and midline shift...
May 9, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29743512/daytime-eyeshine-contributes-to-pupil-camouflage-in-a-cryptobenthic-marine-fish
#13
Matteo Santon, Pierre-Paul Bitton, Ulrike K Harant, Nico K Michiels
Ocular reflectors enhance eye sensitivity in dim light, but can produce reflected eyeshine when illuminated. Some fish can occlude their reflectors during the day. The opposite is observed in cryptic sit-and-wait predators such as scorpionfish and toadfish, where reflectors are occluded at night and exposed during the day. This results in daytime eyeshine, proposed to enhance pupil camouflage by reducing the contrast between the otherwise dark pupil and the surrounding tissue. In this study, we test this hypothesis in the scorpionfish Scorpaena porcus and show that eyeshine is the result of two mechanisms: the previously described Stratum Argenteum Reflected (SAR) eyeshine, and Pigment Epithelium Transmitted (PET) eyeshine, a newly described mechanism for this species...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739727/topographic-anatomy-of-the-subthalamic-nucleus-localized-by-high-resolution-human-brain-atlas-superimposing-digital-images-of-cross-sectioned-surfaces-and-histological-images-of-microscopic-sections-from-frozen-cadaveric-brains
#14
Takashi Kawasaki, Masahiro Shin, Yuiko Kimura, Yoshitomo Umitsu, George Matsumura, Fusako Yokochi, Ryoichi Okiyama, Makoto Taniguchi, Nobutaka Arai
Despite the recent advent of neuro-radiographic techniques, creating a 'perfect' human brain atlas providing precise and consistent images with minimal distortion is practically difficult. In this study, we created a new human brain atlas from cadaveric brains with serial sections of 50 μm thickness covering the entire basal ganglia. Human cerebral hemispheres were obtained from 10 donated cadavers and fixed in 10% formalin solution, cut in a block measuring 50 mm × 30 mm × 50 mm around the midpoint of the anterior and posterior commissures and frozen at -40 °C...
May 5, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29733537/dim-artificial-light-at-night-affects-mating-reproductive-output-and-reactive-oxygen-species-in-drosophila-melanogaster
#15
Lucy Katherine McLay, Venkatesh Nagarajan-Radha, Mark Philip Green, Therésa Melanie Jones
Humans are lighting the night-time environment with ever increasing extent and intensity, resulting in a variety of negative ecological effects in individuals and populations. Effects of light at night on reproductive fitness traits are demonstrated across taxa however, the mechanisms underlying these effects are largely untested. One possible mechanism is that light at night may result in perturbed reactive oxygen species (ROS) and oxidative stress levels. Here, we reared Drosophila melanogaster under either dim (10 lx) light or no light (0 lx) at night for three generations and then compared mating and lifetime oviposition patterns...
May 7, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29727473/can-circadian-dysregulation-exacerbate-migraines
#16
REVIEW
Jason C Ong, Hannah L Taylor, Margaret Park, Helen J Burgess, Rina S Fox, Sarah Snyder, Jeanetta C Rains, Colin A Espie, James K Wyatt
OBJECTIVE: This observational pilot study examined objective circadian phase and sleep timing in chronic migraine (CM) and healthy controls (HC) and the impact of circadian factors on migraine frequency and severity. BACKGROUND: Sleep disturbance has been identified as a risk factor in the development and maintenance of CM but the biological mechanisms linking sleep and migraine remain largely theoretical. METHODS: Twenty women with CM and 20 age-matched HC completed a protocol that included a 7 day sleep assessment at home using wrist actigraphy followed by a circadian phase assessment using salivary melatonin...
May 4, 2018: Headache
https://www.readbyqxmd.com/read/29722480/3-3-diindolylmethane-enhances-glucose-uptake-through-activation-of-insulin-signaling-in-3t3-l1-adipocytes
#17
Kyeong-Mi Choi, Hwan-Soo Yoo
OBJECTIVE: Indole-3-carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3'-diindolylmethane (DIM) reduce body mass and serum glucose levels in high-fat-diet-induced obese mice. This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3-L1 adipocytes, as well as the mechanism involved. METHODS: 3T3-L1 preadipocytes were differentiated by using a mixture of adipogenic inducers, including a suboptimal concentration of insulin...
May 3, 2018: Obesity
https://www.readbyqxmd.com/read/29712749/non-linear-amplification-of-graded-voltage-signals-in-the-first-order-visual-interneurons-of-the-butterfly-papilio-xuthus
#18
Juha Rusanen, Roman Frolov, Matti Weckström, Michiyo Kinoshita, Kentaro Arikawa
Lamina monopolar cells (LMCs) are the first-order visual interneurons of insects and crustacea, primarily involved in achromatic vision. Here we investigated morphological and electrophysiological properties of LMCs in the butterfly Papilio xuthus Using intracellular recording coupled with dye injection, we found two types of LMCs. Cells with roundish terminals near the distal surface of the medulla demonstrating no or small depolarizing spikes were classified as L1/2. LMCs with elongated terminals deep in the medulla that showed prominent spiking were classified as L3/4...
April 30, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29707782/functional-decoupling-of-melatonin-suppression-and-circadian-phase-resetting-in-humans
#19
Shadab A Rahman, Melissa A St Hilaire, Claude Gronfier, Anne-Marie Chang, Nayantara Santhi, Charles A Czeisler, Elizabeth B Klerman, Steven W Lockley
KEY POINTS: There is assumed to be a monotonic association between melatonin suppression and circadian phase resetting induced by light exposure. We tested the association between melatonin suppression and phase resetting in humans. Sixteen young healthy participants received nocturnal bright light (∼9500 lux) exposure of continuous or intermittent patterns, and different durations ranging from 12 min to 6.5 h. Intermittent exposure patterns showed significant phase shifts with disproportionately less melatonin suppression...
April 29, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29705430/technical-note-evaluation-of-the-diagnostic-accuracy-of-2-point-of-care-%C3%AE-hydroxybutyrate-devices-in-stored-bovine-plasma-at-room-temperature-and-at-37%C3%A2-c
#20
F A Leal Yepes, D V Nydam, W Heuwieser, S Mann
The use of point-of-care (POC) devices to measure blood metabolites, such as β-hydroxybutyrate (BHB), on farm have become an important diagnostic and screening tool in the modern dairy industry. The POC devices allow for immediate decision making and are often more economical than the use of laboratory-based methods; however, precision and accuracy may be lower when measurements are performed in an uncontrolled environment. Ideally, the advantages of the POC devices and the standardized laboratory environment could be combined when measuring samples that do not require an immediate result-for example, in research applications or when immediate intervention is not the goal...
April 25, 2018: Journal of Dairy Science
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