keyword
https://read.qxmd.com/read/37743007/effects-of-butyl-benzyl-phthalate-exposure-during-pregnancy-and-lactation-on-the-post-involution-mammary-gland
#21
JOURNAL ARTICLE
Joshua P Mogus, Klara Matouskova, Zachary W Clark, D Joseph Jerry, Laura N Vandenberg
The mammary gland undergoes comprehensive reorganization during pregnancy, lactation, and subsequent involution. Following involution, the mammary gland has structural and functional differences compared to the gland of a nulliparous female. These parity-associated changes are regulated by hormones and may be vulnerable to endocrine-disrupting chemicals (EDCs). In this study, we evaluated the long-term effects of butyl benzyl phthalate (BBP), an estrogenic plasticizer, on the parous mouse mammary gland. Pregnant BALB/c mice were treated with 0, 3, 500, or 18000µg/kg/day BBP throughout both pregnancy and the lactational period...
September 22, 2023: Reproductive Toxicology
https://read.qxmd.com/read/37593105/benzophenone-3-exposure-alters-composition-of-tumor-infiltrating-immune-cells-and-increases-lung-seeding-of-4t1-breast-cancer-cells
#22
JOURNAL ARTICLE
Stephanie M Morin, Kelly J Gregory, Brenda Medeiros, Tigist Terefe, Reyhane Hoshyar, Ahmed Alhusseiny, Shiuan Chen, Richard C Schwartz, D Joseph Jerry, Laura N Vandenberg, Sallie S Schneider
Environmental chemicals are a persistent and pervasive part of everyday life. A subset of environmental chemicals are xenoestrogens, compounds that bind to the estrogen receptor (ER) and drive estrogen-related processes. One such chemical, benzophenone-3 (BP3), is a common chemical in sunscreen. It is a potent UV protectant but also is quickly absorbed through the skin. While it has been approved by the FDA, there is a renewed interest in the safety of BP3, particularly in relation to breast cancer. The focus of this study was to examine the impact that BP3 has on triple negative breast cancer (TNBC) through alterations to cells in the immune microenvironment...
July 2023: Adv Cancer Biol Metastasis
https://read.qxmd.com/read/37527000/antiinflammatory-effect-of-the-ethanolic-extract-of-korean-native-herb-potentilla-rugulosa-nakai-in-bisphenol-a-stimulated-a549-cells
#23
JOURNAL ARTICLE
Yong Geon Choi, Won Seok Choi, Jin Yong Song, Yubin Lee, Su Hyun Lee, Jong Seok Lee, Sarah Lee, Se Rin Choi, Choong Hwan Lee, Ji-Yun Lee
Potentilla rugulosa Nakai ( P . rugulosa ) is a perennial herb in the Rosaceae family and found in the Korean mountains. Previously, our findings demonstrated that P. rugulosa contains numerous polyphenols and flavonoids exhibiting important antioxidant and anti-obesity bioactivities. Bisphenol A (BPA) is a xenoestrogen that was shown to produce pulmonary inflammation in humans. However, the mechanisms underlying BPA-induced inflammation remain to be determined. The aim of this study was to examine whether ethanolic extract of P...
August 1, 2023: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/37493774/in-vitro-evaluation-for-estrogenic-mechanisms-of-the-disinfectant-benzalkonium-chloride-as-an-emerging-contaminant
#24
JOURNAL ARTICLE
Songyi Wei, Xianmin Hu, Xinyi Hu, Yisheng Wan, Guangquan Fan, Jun Wang
This study aimed to evaluate in vitro the possible mechanisms underlying the estrogenic potential of benzalkonium chloride (BAC) as a disinfectant emerging contaminant. Effects of BAC at the environmentally-relevant concentrations on estrogen synthesis and estrogen receptor (ER) signaling were assessed using the H295R steroidogenesis assay and the MCF-7 proliferation assay, respectively. Results showed that exposure to BAC at concentrations of 1.0-1.5 mg/L for 48 h significantly increased estradiol production of H295R cells in a concentration-dependent manner...
2023: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/37473553/estrogens-and-xenoestrogen-residues-in-manure-based-fertilizers-and-their-potential-ecological-risks
#25
JOURNAL ARTICLE
Emmanuel Stephen Odinga, Xuwen Chen, Evance Omondi Mbao, Michael Gatheru Waigi, Fredrick Owino Gudda, Xian Zhou, Wanting Ling, Bożena Czech, Patryk Oleszczuk, Dyaaaldin Abdalmegeed, Yanzheng Gao
Optimal manure treatment aimed at usage as agricultural soil fertilizers is a prerequisite ecological pollution control strategy. In this work, livestock manure-based fertilizers were collected from 71 animal farms across 14 provinces in China. The contamination levels and potential ecotoxicological risks of residual steroid estrogens (SEs): estrone (E1), estriol (E3), 17α-estradiol (17α-E2), 17β-estradiol (17β-E2) and xenoestrogen (XE) bisphenol A (BPA), were investigated. The results showed that the occurrence frequencies for SEs and XE ranged from 66...
July 18, 2023: Journal of Environmental Management
https://read.qxmd.com/read/37437749/the-effect-of-long-term-exposure-to-nonylphenol-at-environmentally-relevant-levels-on-mouse-liver-and-adipose-tissue
#26
JOURNAL ARTICLE
Carolina Martins Ribeiro, Fernanda Cerqueira Barroso de Oliveira, Sidney Alcantara Pereira, Ana Carolina Rocha Oliveira Moraes, Bruna Teles Soares Beserra, Jamison Cordeiro Dias, Nadyellem Graciano da Silva, Mariella Guimarães de Lacerda, Flora Aparecida Milton, Francisco de Assis Rocha Neves, Michella Soares Coelho, Angelica Amorim Amato
Exposure to the xenoestrogen nonylphenol (NP) during critical development windows leads to metabolic abnormalities in adult life. However, less is known about NP exposure outside the developmental period on metabolic outcomes. We investigated the effect of prolonged exposure to NP after sexual maturity and at environmentally relevant concentrations below the 'no observable adverse effects level' (0.5 and 2.5mg/kg/d). Male Swiss mice fed a normal-fat diet exposed to 2.5mg/kg/d NP showed reduced weight gain and hepatic fat content...
July 10, 2023: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/37419023/otolith-shape-and-elemental-signatures-provide-insights-into-the-connectivity-of-euryhaline-chelon-labrosus-inhabiting-two-close-estuaries-with-different-burdens-of-xenoestrogens-in-the-southern-bay-of-biscay
#27
JOURNAL ARTICLE
Anthony Nzioka, Ibon Cancio, Oihane Diaz de Cerio, Edgar Pinto, Agostinho Almeida, Alberto Teodorico Correia
Intersex gonads have been observed in thicklip grey mullet Chelon labrosus, inhabiting estuaries with high burdens of xenoestrogens in the Southeast Bay of Biscay, but knowledge of population connectivity among estuaries is lacking for this euryhaline fish species. This study investigates the population structure of C. labrosus using otolith shape and elemental signatures of 60 adults (overall length ∼ 38 cm) from two estuaries 21 nautic miles apart, one with a high incidence of intersex condition (Gernika), and the other one pristine (Plentzia)...
July 3, 2023: Marine Environmental Research
https://read.qxmd.com/read/37394082/ex-vivo-effects-of-bisphenol-a-or-zearalenone-on-the-prepubertal-rat-testis
#28
JOURNAL ARTICLE
M Drouault, M Rouge, V Hanoux, V Séguin, D Garon, H Bouraïma-Lelong, C Delalande
Bisphenol A (BPA) and zearalenone (ZEA) are two widespread xenoestrogens involved in male reproductive disorders. Few studies investigated the effects of these compounds on the prepubertal testis, which is highly sensitive to endocrine disruptors such as xenoestrogens. An ex vivo approach was performed to evaluate the effects of BPA or ZEA (10-11 , 10-9 , 10-6 M) on the testes of 20 and 25 dpp rats. To investigate the involvement of classical nuclear ER-mediated estrogen signaling in these effects, pre-incubation with an antagonist (ICI 182...
June 30, 2023: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/37379782/lack-of-genetic-structure-in-euryhaline-chelon-labrosus-from-the-estuaries-under-anthropic-pressure-in-the-southern-bay-of-biscay-to-the-coastal-waters-of-the-mediterranean-sea
#29
JOURNAL ARTICLE
Anthony Nzioka, María José Madeira, Lambros Kokokiris, Maren Ortiz-Zarrogoitia, Oihane Diaz de Cerio, Ibon Cancio
Over the last decade, xenoestrogenic effects have been reported in populations of thicklip grey mullet Chelon labrosus from contaminated estuaries in the Bay of Biscay, resulting in intersex condition. To understand the level of gene flow in individuals of different Basque estuaries microsatellite markers were used to evaluate the population structure and connectivity of C. labrosus from estuaries of the Basque coast. 46 microsatellites were tested and 10 validated for the analysis of 204 individuals collected from 5 selected Basque estuaries and 2 outgroups in the Bay of Cadiz and Thermaic Gulf...
June 12, 2023: Marine Environmental Research
https://read.qxmd.com/read/37351388/effect-of-oral-environment-on-contemporary-orthodontic-materials-and-its-clinical-implications
#30
REVIEW
Madhanraj Selvaraj, Kaja Mohaideen, Karthik Sennimalai, Greeshma Shantharam Gothankar, Garima Arora
Contemporary orthodontics entails using advanced materials and devices, simplifying the process of tooth movement. It is well documented that orthodontic materials are subjected to various fluctuations and stresses in the oral environment, such as salivary pH, dietary habits, temperature changes, and masticatory loads. These changes reduce bonding materials' longevity, plasticize resin polymers, and reduce elastic properties. In addition, the corrosion of orthodontic appliances in the oral environment has concerned clinicians for some time...
2023: Journal of Orthodontic Science
https://read.qxmd.com/read/37324741/current-knowledge-on-the-effects-of-environmental-contaminants-in-early-life-nutrition
#31
REVIEW
Maria E Street, Anna-Mariia Shulhai, Roberta Rotondo, Giuliana Giannì, Carlo Caffarelli
Breast milk represents the optimal source of feeding for newborns, in terms of nutritional compounds and as it provides immunological, metabolic, organic, and neurological well-being. As a complex biological fluid, it consists not only of nutritional compounds but also contains environmental contaminants. Formulas through production, contact with bottles and cups, and complementary feeding can also be contaminated. The current review focuses on endocrine-disrupting chemicals, and made-man xenoestrogens present in the environment and both commonly present in food sources, agricultural practices, packaging, consumer products, industry, and medical care...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37224931/the-impacts-of-exposure-to-bisphenol-a-in-the-adult-female-prostate-meriones-unguiculatus
#32
JOURNAL ARTICLE
Carolina Marques Bedolo, Thalles Fernando Rocha Ruiz, Gustavo Matheus Amaro, Patricia Simone Leite Vilamaior, Ellen Cristina Rivas Leonel, Sebastião Roberto Taboga, Silvana Gisele Pegorin de Campos
The female prostate is associated with the urogenital system and presents homology in morphological terms with the male prostate. Due to its responsiveness to endogenous hormones, this gland is under a constant risk of developing prostatic pathologies and neoplasia when exposed to certain exogenous compounds. Bisphenol A (BPA) is an endocrine disruptor found in different plastic and resin products. Studies have emphasized the effects of perinatal exposure to this compound on different hormone-responsive organs...
May 22, 2023: Reproductive Toxicology
https://read.qxmd.com/read/37175656/the-state-of-research-and-weight-of-evidence-on-the-epigenetic-effects-of-bisphenol-a
#33
JOURNAL ARTICLE
Ahmad Besaratinia
Bisphenol A (BPA) is a high-production-volume chemical with numerous industrial and consumer applications. BPA is extensively used in the manufacture of polycarbonate plastics and epoxy resins. The widespread utilities of BPA include its use as internal coating for food and beverage cans, bottles, and food-packaging materials, and as a building block for countless goods of common use. BPA can be released into the environment and enter the human body at any stage during its production, or in the process of manufacture, use, or disposal of materials made from this chemical...
April 27, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36877263/non-target-estrogenic-screening-of-60-pesticides-six-plant-protection-products-and-tomato-grape-and-wine-samples-by-planar-chromatography-combined-with-the-planar-yeast-estrogen-screen-bioassay
#34
JOURNAL ARTICLE
Annabel Mehl, Sophia Seiferling, Gertrud E Morlock
For non-target residue analysis of xenoestrogens in food, sophisticated chromatographic-mass spectrometric techniques lack in biological effect detection. Various in vitro assays providing sum values encounter problems when opposing signals are present in a complex sample. Due to physicochemical signal reduction, cytotoxic or antagonistic effect responses, the resulting sum value is falsified. Instead, the demonstrated non-target estrogenic screening with an integrated planar chromatographic separation differentiated opposing signals, detected and prioritized important estrogenic compounds, and directly assigned tentatively the responsible compounds...
March 6, 2023: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/36831333/estrogen-signaling-influences-nephron-segmentation-of-the-zebrafish-embryonic-kidney
#35
JOURNAL ARTICLE
Hannah M Wesselman, Allison E Gatz, Mairead R Pfaff, Liana Arceri, Rebecca A Wingert
Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. In an effort to identify elusive regulators of nephron segmentation, our lab conducted a high-throughput drug screen using a bioactive chemical library and developing zebrafish, which are a conserved vertebrate model and particularly conducive to large-scale screening approaches. 17β-estradiol (E2), which is the dominant form of estrogen in vertebrates, was a particularly interesting hit from this screen...
February 20, 2023: Cells
https://read.qxmd.com/read/36828952/bisphenol-a-bpa-impairs-hippocampal-neurogenesis-via-inhibiting-regulation-of-the-ubiquitin-proteasomal-system
#36
JOURNAL ARTICLE
Sangh Jyoti Singh, Ankit Tandon, Phoolmala, Tulika Srivastava, Nivedita Singh, Shweta Goyal, Smriti Priya, Rajnish Kumar Chaturvedi
The ubiquitin-proteasome system (UPS) controls protein homeostasis to maintain cell functionality and survival. Neurogenesis relies on proteasome function, and a defective proteasome system during brain development leads to neurological disorders. An endocrine-disrupting xenoestrogen bisphenol-A (BPA) used in plastic products adversely affects human health and causes neurotoxicity. Previously, we reported that BPA reduces neural stem cells (NSCs) proliferation and differentiation, impairs myelination and mitochondrial protein import, and causes excessive mitochondrial fragmentation leading to cognitive impairments in rats...
February 25, 2023: Molecular Neurobiology
https://read.qxmd.com/read/36828454/comparative-analysis-of-transcriptomic-changes-including-mrna-and-microrna-expression-induced-by-the-xenoestrogens-zearalenone-and-bisphenol-a-in-human-ovarian-cells
#37
JOURNAL ARTICLE
Éva Márton, Alexandra Varga, András Penyige, Zsuzsanna Birkó, István Balogh, Bálint Nagy, Melinda Szilágyi
Xenoestrogens are natural or synthetic compounds that mimic the effect of endogenous estrogens and might cause cancer. We aimed to compare the global transcriptomic response to zearalenone (ZEA; mycotoxin) and bisphenol A (BPA; plastic additive) with the effect of physiological estradiol (E2) in the PEO1 human ovarian cell line by mRNA and microRNA sequencing. Estrogen exposure induced remarkable transcriptomic changes: 308, 288 and 63 genes were upregulated (log2 FC > 1); 292, 260 and 45 genes were downregulated (log2 FC < -1) in response to E2 (10 nM), ZEA (10 nM) and BPA (100 nM), respectively...
February 9, 2023: Toxins
https://read.qxmd.com/read/36803253/effects-of-17%C3%AE-ethinylestradiol-on-the-neuroendocrine-gonadotropic-system-and-behavior-of-european-sea-bass-larvae-dicentrarchus-labrax
#38
JOURNAL ARTICLE
S Soloperto, S Olivier, A Poret, C Minier, M P Halm-Lemeille, C Jozet-Alves, S Aroua
The widespread use of 17α-ethinylestradiol (EE2), and other estrogenic endocrine disruptors, results in a continuous release of estrogenic compounds into aquatic environments. Xenoestrogens may interfere with the neuroendocrine system of aquatic organisms and may produce various adverse effects. The aim of the present study was to expose European sea bass larvae ( Dicentrarchus labrax ) to EE2 (0.5 and 50 nM) for 8 d and determine the expression levels of brain aromatase ( cyp19a1b ), gonadotropin-releasing hormones ( gnrh1, gnrh2, gnrh3 ), kisspeptins ( kiss1 , kiss2 ) and estrogen receptors ( esr1, esr2a, esr2b, gpera, gperb )...
February 20, 2023: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/36774708/high-production-of-transfer-rnas-identifies-the-presence-of-developing-oocytes-in-ovaries-and-intersex-testes-of-teleost-fish
#39
JOURNAL ARTICLE
Joyanta Bir, Iratxe Rojo-Bartolomé, Xabier Lekube, Oihane Diaz de Cerio, Maren Ortiz-Zarragoitia, Ibon Cancio
5S rRNA is highly transcribed in fish oocytes and this transcription levels can be used to identify the presence of oocytes in the intersex testes of fish exposed to xenoestrogens. Similar to 5S rRNA, tRNAs are transcribed by RNA polymerase III (Pol-III) in eukaryotes, so this study focuses in the analysis of the levels of expression of tRNAs in the gonads (ovaries and testes) of eight teleost species as a possible new oocyte molecular marker. Total RNA extracted from gonads of six commercial teleost species in the Biscay Bay, from the pollution sentinel species thicklip grey mullet (Chelon labrosus) known present intersex testes in response to xenoestrogens in Gernika estuary and from the laboratory model species Danio rerio were analysed through capillary electrophoresis...
February 9, 2023: Marine Environmental Research
https://read.qxmd.com/read/36750500/effects-of-perinatal-exposure-to-bisphenol-a-or-s-in-eae-model-of-multiple-sclerosis
#40
JOURNAL ARTICLE
Brigitta Bonaldo, Antonino Casile, Francesca Montarolo, Martina Bettarelli, Francesca Napoli, Stefano Gotti, GianCarlo Panzica, Marilena Marraudino
Epidemiological studies support the idea that multiple sclerosis (MS) is a multifactorial disease, overlapping genetic, epigenetic, and environmental factors. A better definition of environmental risks is critical to understand both etiology and the sex-related differences of MS. Exposure to endocrine-disrupting compounds (EDCs) fully represents one of these risks. EDCs are natural or synthetic exogenous substances (or mixtures) that alter the functions of the endocrine system. Among synthetic EDCs, exposure to bisphenol A (BPA) has been implicated in the etiology of MS, but to date, controversial data has emerged...
February 8, 2023: Cell and Tissue Research
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