keyword
MENU ▼
Read by QxMD icon Read
search

Colorectal cancer type-x

keyword
https://www.readbyqxmd.com/read/29756671/wasabi-6-methylsulfinyl-hexyl-isothiocyanate-induces-apoptosis-in-human-colorectal-cancer-cells-through-p53-independent-mitochondrial-dysfunction-pathway
#1
Satoshi Yano, Shusong Wu, Kozue Sakao, De-Xing Hou
6-(Methylsulfinyl)hexyl isothiocyanate (6-MSITC), a major bioactive compound in Wasabi [Wasabia japonica (Miq.) Matsum.], has revealed the inhibitory effect on colon carcinogenesis in rat cancer model although the underlying mechanism is unclear. In this study, we used two types of human colorectal cancer cells (HCT116 p53+/+ and HCT116 p53-/- ) to investigate the anticancer activity and molecular mechanisms of 6-MSITC. Interestingly, 6-MSITC inhibited the cell proliferation in both types of cells with similar IC50 value although a light increase in the phosphorylation and accumulation of P53 protein was observed in HCT116 p53+/+ cells at 24 h after treatment...
May 14, 2018: BioFactors
https://www.readbyqxmd.com/read/29738772/dihydroartemisinin-potentiates-antitumor-activity-of-5-fluorouracil-against-a-resistant-colorectal-cancer-cell-line
#2
Zhihan Yao, Adheesh Bhandari, Yinghao Wang, Yiyuan Pan, Fan Yang, Rongfa Chen, Erjie Xia, Ouchen Wang
Although the combination of chemotherapy and surgical resection has effectively increased the survival rate of colorectal cancer patients in recent decades, acquired drug resistance is still a problem that leads to treatment failure. Dihydroartemisinin (DHA), a semisynthetic derivative of artemisinin, has recently been reported to show anticancer effects against numerous types of cancer, including colorectal cancer. This study showed that DHA exerted a strong anticancer effect against several colorectal cancer cell lines...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29719205/cxcr4-overexpression-is-correlated-with-poor-prognosis-in-colorectal-cancer
#3
Chao Xu, Linfeng Zheng, Dechuan Li, Guoping Chen, Jianzhong Gu, Jun Chen, Qinghua Yao
AIMS: Colorectal cancer threatens human health due to its high mortality resulting from metastatic progression. The expression of C-X-C chemokine receptor type 4 (CXCR4) is absent or low in most healthy tissues but high in various types of tumours. In this study, we aim to determine the prognostic significance of CXCR4 in colorectal cancer. MAIN METHODS: We retrospectively examined a total of 72 tissue samples, that qRT-PCR and immunohistochemistry were performed to detect the expression of CXCR4 as well as univariate and multivariate analyses were performed to explore the overall survival...
April 29, 2018: Life Sciences
https://www.readbyqxmd.com/read/29629665/overall-and-multiphasic-findings-of-the-prostate-lung-colorectal-and-ovarian-plco-randomized-cancer-screening-trial
#4
Philip C Prorok, Patrick Wright, Thomas R Riley, Barnett S Kramer, Christine D Berg, John K Gohagan
BACKGROUND: Screening tests are typically evaluated for a single disease, but multiple tests for multiple diseases are performed in practice. The Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial assessed testing for four cancers simultaneously and can be viewed as a multiphasic cancer intervention. This paper presents overall and multiphasic findings of this trial. METHODS: The PLCO trial was a randomized multi-center trial conducted at ten screening centers in the US...
April 9, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29620285/effect-of-hoxa6-on-the-proliferation-apoptosis-migration-and-invasion-of-colorectal-cancer-cells
#5
Shasha Wu, Feixiang Wu, Zheng Jiang
Colorectal cancer (CRC) is one of the most common types of tumor worldwide. The morbidity and mortality rates of CRC have increased significantly in adults <50 years of age. In the present study, the effects of homeobox A6 (HOXA6) on the proliferation, apoptosis, migration and invasion of CRC cells were investigated. The results of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis demonstrated that the expression of HOXA6 in CRC tumor tissue was higher than that in adjacent normal tissue...
April 2, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29620273/p38-inhibitor-inhibits-the-apoptosis-of-cowanin-treated-human-colorectal-adenocarcinoma-cells
#6
Nittiya Chowchaikong, Sirinun Nilwarangkoon, Surat Laphookhieo, Chantra Tanunyutthawongse, Ramida Watanapokasin
Colorectal cancer, which is the third most common type of cancer diagnosed in both men and women, is the leading cause of cancer-related deaths worldwide. Cowanin is a pure compound extracted from Garcinia cowa Roxb., a tree species present in Thailand, Malaysia and Myanmar. The crude extract has been demonstrated to have antitumor activity, inflammation induction, antibacterial activity, anti-inflammatory activity and antimalarial activity. In the present study, the effects of cowanin on apoptosis induction and on the apoptosis-related and mitogen-activated protein kinase (MAPK) pathways were investigated in the LoVo human colorectal cancer cell line...
April 3, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29593423/high-expression-of-col10a1-is-associated-with-poor-prognosis-in-colorectal-cancer
#7
Haipeng Huang, Tingting Li, Gengtai Ye, Liying Zhao, Zhenzhan Zhang, Debin Mo, Yiming Wang, Ce Zhang, Haijun Deng, Guoxin Li, Hao Liu
Background: High expression of collagen type X alpha 1 chain (COL10A1), a member of the collagen family, had been observed in various human cancers, but the detailed function and molecular mechanism of COL10A1 were largely unclear. Aim: The aim of this study was to investigate the expression of COL10A1 in colorectal cancer (CRC) tissues and cells and to reveal its biological function and mechanism in CRC. Materials and methods: Immunohistochemistry (IHC), real-time quantitative polymerase chain reaction (QPCR) and Western blot experiments were used to determine the clinical relevance between expression levels of COL10A1 and CRC...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29545901/loss-of-expression-rather-than-cytoplasmic-mislocalization-of-runx3-predicts-worse-outcome-in-non-small-cell-lung-cancer
#8
Xiaohui Chen, Yujie Deng, Yi Shi, Weifeng Zhu, Yibin Cai, Chunwei Xu, Kunshou Zhu, Xiongwei Zheng, Gang Chen, Qi Xie, Guoxing Weng
Functional inactivation of human runt-related transcription factor 3 (RUNX3) through mutation or epigenetic silencing has been well-documented in many cancerous entities. In addition to gene mutation and promoter hypermethylation, cytoplasmic mislocalization has emerged as another major manifestation of RUNX3 dysfunction in malignancies including breast, colorectal and gastric cancers. The aim of the present study was to investigate whether patients with non-small cell lung cancer (NSCLC) and different RUNX3 expression patterns would have different overall survival (OS), and the associations between different patterns of clinicopathological parameters and clinical outcome...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29443050/a-co-culture-method-to-investigate-the-crosstalk-between-x-ray-irradiated-caco-2-cells-and-pbmc
#9
Gabriele Babini, Jacopo Morini, Sofia Barbieri, Giorgio Baiocco, Giovanni Battista Ivaldi, Marco Liotta, Paola Tabarelli de Fatis, Andrea Ottolenghi
The protocol adopted in this work aims at unraveling how X-rays perturb the functioning of the intestinal barrier, focusing on the interplay between colorectal tumor cells and the immune system. Colorectal carcinoma is among the most common type of cancer, typically treated by surgery, chemotherapy, and radiotherapy. Advantages of radiotherapy in targeting the tumor are well known. However, even limited exposures of healthy tissues are of great concern, particularly regarding the effects on the intestinal barrier and the immune system...
January 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29425227/interaction-between-polymorphisms-in-aspirin-metabolic-pathways-regular-aspirin-use-and-colorectal-cancer-risk-a-case-control-study-in-unselected-white-european-populations
#10
Harsh Sheth, Emma Northwood, Cornelia M Ulrich, Dominique Scherer, Faye Elliott, Jennifer H Barrett, David Forman, C Roland Wolf, Gillian Smith, Michael S Jackson, Mauro Santibanez-Koref, Robert Haile, Graham Casey, Mark Jenkins, Aung Ko Win, John L Hopper, Loic Le Marchand, Noralane M Lindor, Stephen N Thibodeau, John D Potter, John Burn, D Timothy Bishop
Regular aspirin use is associated with reduced risk of colorectal cancer (CRC). Variation in aspirin's chemoprevention efficacy has been attributed to the presence of single nucleotide polymorphisms (SNPs). We conducted a meta-analysis using two large population-based case-control datasets, the UK-Leeds Colorectal Cancer Study Group and the NIH-Colon Cancer Family Registry, having a combined total of 3325 cases and 2262 controls. The aim was to assess 42 candidate SNPs in 15 genes whose association with colorectal cancer risk was putatively modified by aspirin use, in the literature...
2018: PloS One
https://www.readbyqxmd.com/read/29365411/-report-of-cancer-incidence-and-mortality-in-china-2014
#11
W Q Chen, H Li, K X Sun, R S Zheng, S W Zhang, H M Zeng, X N Zou, X Y Gu, J He
Objective: The registration data of local cancer registries in 2014 were collected by National Central Cancer Registry (NCCR)in 2017 to estimate the cancer incidence and mortality in China. Methods: The data submitted from 449 registries were checked and evaluated, and the data of 339 registries out of them were qualified and selected for the final analysis. Cancer incidence and mortality were stratified by area, gender, age group and cancer type, and combined with the population data of 2014 to estimate cancer incidence and mortality in China...
January 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29344237/chloroform-extract-of-hedyotis-diffusa-willd-inhibits-viability-of-human-colorectal-cancer-cells-via-suppression-of-akt-and-erk-signaling-pathways
#12
Zhaokun Yan, Jianyu Feng, Jun Peng, Zijun Lai, Ling Zhang, Yiyi Jin, Hong Yang, Wujin Chen, Jiumao Lin
Hedyotis diffusa Willd (HDW) is a widely used traditional Chinese medicine in clinical therapy to treat various types of cancer, including colorectal cancer (CRC), but its effective polar fractions and functional mechanisms remain unclear. The aim of the present study was to determine the most effective extract of HDW and to investigate its effects on the regulation of CRC cell proliferation and apoptosis, as well as to investigate the underlying molecular mechanisms. The results demonstrated that the chloroform extract of HDW (CEHDW) exhibited the most anticancer ability...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29328398/synergistic-antitumor-effect-of-brusatol-combined-with-cisplatin-on-colorectal-cancer-cells
#13
Hai-Ming Chen, Zheng-Quan Lai, Hui-Jun Liao, Jian-Hui Xie, Yan-Fang Xian, Yun-Long Chen, Siu-Po Ip, Zhi-Xiu Lin, Zi-Ren Su
Colorectal cancer (CRC) is a common and life‑threatening type of malignant cancer, which is associated with a high mortality rate. Cisplatin (CDDP) is a commonly used chemotherapy drug with significant side effects. Brusatol (BR) is one of the principal chemical compounds isolated from the Chinese herb Bruceae Fructus, which has been reported to markedly inhibit the proliferation of numerous cancer cell lines. The present study aimed to investigate the possible synergistic anticancer effects of CDDP combined with BR on CT‑26 cells, and to evaluate the underlying mechanisms of action...
March 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29243075/the-effect-of-aspirin-on-circulating-tumor-cells-in-metastatic-colorectal-and-breast-cancer-patients-a-phase-ii-trial-study
#14
L Yang, Z Lv, W Xia, W Zhang, Y Xin, H Yuan, Y Chen, X Hu, Y Lv, Q Xu, X Weng, C Ni
PURPOSE: Aspirin could reduce the risk of cancer metastasis. Circulating tumor cells (CTCs) are a key factor of cancer metastasis, but no evidence has revealed how aspirin affects CTCs and its epithelial-mesenchymal transition (EMT). Here, we conducted a clinical trial to investigate how aspirin affects CTCs in metastatic colorectal cancer (MCC) and breast cancer patients (MBC). METHODS: The trial is retrospective registered at clinicaltrials.gov (NCT02602938). The eligible patients are given 100 mg aspirin q...
December 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29237383/the-effect-of-flubendazole-on-adhesion-and-migration-in-sw480-and-sw620-colon-cancer-cells
#15
Veronika Hanusova, Lenka Skalova, Vera Kralova, Petra Matouskovs
Colon cancer is the most common type of gastrointestinal cancer. Despite advances during the last two decades, the efficacy of colorectal cancer treatment is still insufficient and new anticancer agents are necessary. In our study, colon cancer cells derived from a primary tumor (SW480) and lymph node metastasis (SW620) from the same patient were used and compared. The effect of FLU on cell adhesion and migration was monitored using the x-CELLigence Real-Time Cell Analysis system. Expressions of molecules involved in adhesion and migration were analyzed using RT-PCR and western blot...
December 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29215479/major-abdominal-and-perianal-surgery-in-crohn-s-disease-long-term-follow-up-of-australian-patients-with-crohn-s-disease
#16
MULTICENTER STUDY
James W T Toh, Nelson Wang, Christopher J Young, Matthew J F X Rickard, Anil Keshava, Peter Stewart, Viraj Kariyawasam, Rupert Leong
BACKGROUND: Most patients with Crohn's disease still require surgery despite significant advances in medical therapy, surveillance, and management strategies. OBJECTIVE: The purpose of this study was to assess surgical strategies and outcomes in Crohn's disease, including surgical recurrence and emergency surgery. DESIGN: This was a multicenter, retrospective review of a prospectively collected database. SETTINGS: A specialist-referred cohort of patients with Crohn's disease between 1970 and 2009 was studied...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29193645/mapk-inhibitors-induce-serine-peptidase-inhibitor-kazal-type-1-spink1-secretion-in-braf-v600e-mutant-colorectal-adenocarcinoma
#17
Kati Räsänen, Kien X Dang, Harri Mustonen, Tho H Ho, Susanna Lintula, Hannu Koistinen, Ulf-Håkan Stenman, Caj Haglund, Jakob Stenman
The mitogen-activated protein kinase (MAPK) pathway plays a central role in colorectal cancers (CRC). In particular, BRAF V600E-mutant tumors, which represent around 10% of CRCs, are refractory to current therapies. Overexpression and secretion of serine peptidase inhibitor Kazal type 1 (SPINK1) are observed in around 50% of CRCs, and its serum level can be used as a biomarker for poor prognosis. Utilizing a recently developed extendable blocking probe assay, we analyzed the BRAF mutation status in a CRC patient cohort (N = 571) using tissue-derived RNA as the starting material...
February 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29113248/gene-expression-profile-comparison-between-colorectal-cancer-and-adjacent-normal-tissues
#18
Qian Yang, Maohui Feng, Xiang Ma, Huachi Li, Wei Xie
The present study aimed to compare gene expression profiles between colorectal cancer and adjacent normal tissues, and to perform a preliminarily analysis of the key genes and underlying molecular mechanisms implicated in colorectal cancer development. Gene expression microarray chips were used to screen genes that were differently expressed between colorectal cancer and adjacent normal tissues. Approximately 1,183 genes were differentially expressed in cancer tissues compared with adjacent normal tissues (P≤0...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29113214/ginkgolic-acid-inhibits-the-invasiveness-of-colon-cancer-cells-through-ampk-activation
#19
Lina Qiao, Jianbao Zheng, Xianzhen Jin, Guangbing Wei, Guanghui Wang, Xuejun Sun, Xuqi Li
Tumor cell invasion and metastasis are important processes in colorectal cancer that exert negative effects on patient outcomes; consequently, a prominent topic in the field of colorectal cancer study is the identification of safe and affordable anticancer drugs against cell invasion and metastasis, with limited side effects. Ginkgolic acid is a phenolic acid extracted from ginkgo fruit, ginkgo exotesta and ginkgo leaves. Previous studies have indicated that ginkgolic acid inhibits tumor growth and invasion in a number of types of cancer; however, limited studies have considered the effects of ginkgolic acid on colon cancer...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29096939/familial-colorectal-cancer-type-x-fcctx-and-the-correlation-with-various-genes-a-systematic-review
#20
REVIEW
Mahdieh Nejadtaghi, Hamideh Jafari, Effat Farrokhi, Keihan Ghatreh Samani
Familial Colorectal Cancer Type X (FCCTX) is a type of hereditary nonpolyposis colorectal cancer in accordance to Amsterdam criteria-1 for Lynch syndrome, with no related mutation in mismatch repair gene. FCCTX is microsatellite stable and is accounted for 40% of families with Amsterdam criteria-1 with a high age of onset. Thus, the carcinogenesis of FCCTX is different compared to Lynch syndrome. In addition to the microsatellite stability and the presence of less predominant tumors in proximal colon, various clinical features have also been associated with FCCTX in comparison with Lynch syndrome such as no increased risk of extra-colonic cancers, older age of diagnosis and higher adenoma/carcinoma rate...
November 2017: Current Problems in Cancer
keyword
keyword
51534
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"