keyword
https://read.qxmd.com/read/38468501/-cancer-incidence-and-mortality-in-china-2022
#1
JOURNAL ARTICLE
R S Zheng, R Chen, B F Han, S M Wang, L Li, K X Sun, H M Zeng, W W Wei, J He
Objective: The National Central Cancer Registry estimates the number of new cancer cases and deaths in China in 2022, using incidence and mortality data collected by the National Cancer Center. Methods: According to the data of 700 cancer registries in 2018 and the data of 106 cancer registries from 2010 to 2018, the age-period-cohort model was used to estimate the incidence rate and mortality rate of all cancers and 23 types of cancer in 2022, stratified by gender and urban and rural areas. We estimated the number of new cancer cases and deaths in China in 2022 based on the estimated rate and population data in 2022...
March 12, 2024: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://read.qxmd.com/read/38454087/progress-in-site-specific-cancer-mortality-in-canada-over-the-last-70%C3%A2-years
#2
JOURNAL ARTICLE
Matthew T Warkentin, Yibing Ruan, Larry F Ellison, Jean-Michel Billette, Alain Demers, Fei-Fei Liu, Darren R Brenner
In Canada, the absolute number of cancer deaths has been steadily increasing, however, age-standardized cancer mortality rates peaked decades ago for most cancers. The objective of this study was to estimate the reduction in deaths for each cancer type under the scenario where peak mortality rates had remained stable in Canada. Data for this study were obtained the Global Cancer Observatory and Statistics Canada. We estimated age-standardized mortality rates (ASMR, per 100,000) from 1950 to 2022, standardized to the 2011 Canadian standard population...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38398196/synchrotron-radiation-refraction-contrast-computed-tomography-based-on-x-ray-dark-field-imaging-optics-of-pulmonary-malignancy-comparison-with-pathologic-examination
#3
JOURNAL ARTICLE
Eunjue Yi, Naoki Sunaguchi, Jeong Hyeon Lee, Seung-Jun Seo, Sungho Lee, Daisuke Shimao, Masami Ando
Refraction-contrast computed tomography based on X-ray dark-field imaging (XDFI) using synchrotron radiation (SR) has shown superior resolution compared to conventional absorption-based methods and is often comparable to pathologic examination under light microscopy. This study aimed to investigate the potential of the XDFI technique for clinical application in lung cancer diagnosis. Two types of lung specimens, primary and secondary malignancies, were investigated using an XDFI optic system at beamline BL14B of the High-Energy Accelerator Research Organization Photon Factory, Tsukuba, Japan...
February 16, 2024: Cancers
https://read.qxmd.com/read/38376789/hsk3486-inhibits-colorectal-cancer-growth-by-promoting-oxidative-stress-and-atpase-inhibitory-factor-1-activation
#4
JOURNAL ARTICLE
Ke Nan, Ziwen Zhong, Ying Yue, Wenchang Zhou, Xingfeng Sun, Yang Shen, Mengdi Qu, Zhaoyuan Chen, Jiahui Gu, Caihong Sun, Xun Sun, Lihong Lu, Jie Zhang, Changhong Miao, Minli Sun
BACKGROUND: HSK3486 (ciprofol), a new candidate drug similar to propofol, exerts sedative and hypnotic effects through gamma-aminobutyric acid type A receptors; however, its potential role in colorectal cancer is currently unknown. AIMS: This study aimed to evaluate the effects of HSK3486 on colorectal cancer cell proliferation. METHODS: Imaging was performed to detect reactive oxygen species and mitochondrial membrane potential. Western blotting was used to determine the expression of target signals...
February 20, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38326022/nanoliposome-loaded-phenolics-from-salvia-leriifolia-benth-and-its-anticancer-effects-against-induced-colorectal-cancer-in-mice
#5
JOURNAL ARTICLE
Niusha Shojaee Nasrabadi, Arezoo Vedad, Kimia Asadi, Mahsa Rastegar Moghaddam Poorbagher, Nadia Abdollahian Tabrizi, Kiyana Dorooki, Roghayeh Sabouhi Sabouni, Mahla Barati Moghadam, Negin Shafaei, Ehsan Karimi, Ehsan Oskoueian
Colon cancer is one of the leading causes of death among various types of cancer. Despite the significant progress made in cancer treatment, chemotherapy resistance and various side effects are still prevalent. The objective of this study is to assess the therapeutic potential of phenolic-rich fraction encapsulated nanoliposome (PRF-NLs) of Salvia leriifolia Benth in the treatment of colon cancer in mice. Initially, the phenolic-rich fraction (PRF) was extracted and then encapsulated into nanoliposomes. The physicochemical properties of the nanoliposomes were evaluated using dynamic light scattering, zeta potential, and field emission scanning electron microscopy...
February 7, 2024: Biotechnology and Applied Biochemistry
https://read.qxmd.com/read/38322560/association-between-immune-related-hub-genes-cd36-cxcl13-fgfr4-gabbr1-lamp3-mmp12-and-ppm1h-and-colorectal-cancer-prognosis
#6
JOURNAL ARTICLE
Liuli Wang, Xiaohua Dong, Miao Yu, Xiazi Nie, Mengmeng Du, Xiashuang Zhao, Yipeng Zhang, Hui Cai
The present study aims to identify immune-related prognostic genes in colorectal cancer (CRC), and to explore potential mechanisms through which these genes regulate CRC progression. We first constructed a prognostic risk model based on seven gene signatures [cluster of differentiation-36 ( CD36 ), chemokine (C-X-C-motif) ligand 13 ( CXCL13 ), fibroblast growth factor receptor 4 ( FGFR4 ), gamma-amino-butyric acid type B receptor 1 ( GABBR1 ), lysosome-associated membrane glycoprotein 3 ( LAMP3 ), recombinant matrix metalloproteinase 12 ( MMP12 ), and protein phosphatase 1H ( PPM1H )] using integrated bioinformatic analyses...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38267731/activation-of-chpf-by-transcription-factor-nfic-promotes-nlrp3-activation-during-the-progression-of-colorectal-cancer
#7
JOURNAL ARTICLE
Jiamei Wu, Miao Wang, Yuechuan Zhang, Guohong Liu, Yutong Xing
Given the role of chondroitin polymerizing factor (CHPF) in several cancers, we investigated its role in the progression of colorectal cancer (CRC) and its association with NLRP3 inflammasome activation. High expression of CHPF in CRC predicted poor patient prognosis. Using colony formation, EdU staining, wound healing, Transwell invasion, and flow cytometry assays, we revealed that the downregulation of CHPF inhibited the malignant behavior of CRC cells. CHPF promoted NLRP3 inflammasome activation by inducing the MAPK signaling pathway, as evidenced by enhanced expression of Phos-ERK1/2, Phos-MEK1, Phos-MEK2, and NLRP3...
January 24, 2024: Functional & Integrative Genomics
https://read.qxmd.com/read/38247803/a-novel-protozoa-parasite-derived-protein-adjuvant-is-effective-in-immunization-with-cancer-cells-to-activate-the-cancer-specific-protective-immunity-and-inhibit-the-cancer-growth-in-a-murine-model-of-colorectal-cancer
#8
JOURNAL ARTICLE
Rajesh Mani, Chloe G Martin, Kanal E Balu, Qingding Wang, Piotr Rychahou, Tadahide Izumi, B Mark Evers, Yasuhiro Suzuki
Cancer-specific CD8+ cytotoxic T cells play important roles in preventing cancer growth, and IFN-γ, in addition to IL-12 and type I interferon, is critical for activating CD8+ cytotoxic T cells. We recently identified the capability of the amino-terminus region of dense granule protein 6 (GRA6Nt) of Toxoplasma gondii , an intracellular protozoan parasite, to activate IFN-γ production of microglia, a tissue-resident macrophage population. Therefore, in the present study, we examined whether recombinant GRA6Nt protein (rGRA6Nt) functions as an effective adjuvant to potently activate cancer-specific protective immunity using a murine model of MC38 colorectal cancer (CRC)...
January 6, 2024: Cells
https://read.qxmd.com/read/38230407/repurposing-celecoxib-for-colorectal-cancer-targeting-via-ph-triggered-ultra-elastic-nanovesicles-pronounced-efficacy-through-up-regulation-of-wnt-%C3%AE-catenin-pathway-in-dmh-induced-tumorigenesis
#9
JOURNAL ARTICLE
Shahira F El Menshawe, Khaled Shalaby, Mohammed H Elkomy, Heba M Aboud, Yasmin M Ahmed, Abdelmeged A Abdelmeged, Marwa Elkarmalawy, Mahmoud A Abou Alazayem, Amani M El Sisi
Celecoxib (CLX), a selective inhibitor for cyclooxygenase 2 (COX-2), has manifested potential activity against diverse types of cancer. However, low bioavailability and cardiovascular side effects remain the major challenges that limit its exploitation. In this work, we developed ultra-elastic nanovesicles (UENVs) with pH-triggered surface charge reversal traits that could efficiently deliver CLX to colorectal segments for snowballed tumor targeting. CLX-UENVs were fabricated via a thin-film hydration approach...
June 2024: International journal of pharmaceutics: X
https://read.qxmd.com/read/38151510/characterization-of-wnt-signaling-pathway-under-treatment-of-lactobacillus-acidophilus-postbiotic-in-colorectal-cancer-using-an-integrated-in-silico-and-in-vitro-analysis
#10
JOURNAL ARTICLE
Nafiseh Erfanian, Saeed Nasseri, Adib Miraki Feriz, Hossein Safarpour, Mohammad Hassan Namaie
Colorectal cancer (CRC) is a prevalent and life-threatening cancer closely associated with the gut microbiota. Probiotics, as a vital microbiota group, interact with the host's colonic epithelia and immune cells by releasing a diverse range of metabolites named postbiotics. The present study examined the effects of postbiotics on CRC's prominent differentially expressed genes (DEGs) using in silico and in vitro analysis. Through single-cell RNA sequencing (scRNA-seq), we identified four DEGs in CRC, including secreted frizzled-related protein 1 (SFRP1), secreted frizzled-related protein 2 (SFRP2), secreted frizzled-related protein 4 (SFRP4), and matrix metallopeptidase 7 (MMP7)...
December 27, 2023: Scientific Reports
https://read.qxmd.com/read/38139160/unsymmetrical-pd-ii-pincer-complexes-with-benzothiazole-and-thiocarbamate-flanking-units-expedient-solvent-free-synthesis-and-anticancer-potential
#11
JOURNAL ARTICLE
Vladimir A Kozlov, Diana V Aleksanyan, Svetlana G Churusova, Aleksandr A Spiridonov, Ekaterina Yu Rybalkina, Evgenii I Gutsul, Svetlana A Aksenova, Alexander A Korlyukov, Alexander S Peregudov, Zinaida S Klemenkova
Driven by the growing threat of cancer, many research efforts are directed at developing new chemotherapeutic agents, where the central role is played by transition metal complexes. The proper ligand design serves as a key factor to unlock the anticancer potential of a particular metal center. Following a recent trend, we have prepared unsymmetrical pincer ligands that combine benzothiazole and thiocarbamate donor groups. These compounds are shown to readily undergo direct cyclopalladation, affording the target S , C , N -type Pd(II) pincer complexes both in solution and in the absence of a solvent...
December 10, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38110959/smoother-a-unified-and-modular-framework-for-incorporating-structural-dependency-in-spatial-omics-data
#12
JOURNAL ARTICLE
Jiayu Su, Jean-Baptiste Reynier, Xi Fu, Guojie Zhong, Jiahao Jiang, Rydberg Supo Escalante, Yiping Wang, Luis Aparicio, Benjamin Izar, David A Knowles, Raul Rabadan
Spatial omics technologies can help identify spatially organized biological processes, but existing computational approaches often overlook structural dependencies in the data. Here, we introduce Smoother, a unified framework that integrates positional information into non-spatial models via modular priors and losses. In simulated and real datasets, Smoother enables accurate data imputation, cell-type deconvolution, and dimensionality reduction with remarkable efficiency. In colorectal cancer, Smoother-guided deconvolution reveals plasma cell and fibroblast subtype localizations linked to tumor microenvironment restructuring...
December 18, 2023: Genome Biology
https://read.qxmd.com/read/38102129/targeting-akt-induced-ferroptosis-through-fto-ythdf2-dependent-gpx4-m6a-methylation-up-regulating-and-degradating-in-colorectal-cancer
#13
JOURNAL ARTICLE
Ge Zhang, Wunan Mi, Chuyue Wang, Jiehan Li, Yizheng Zhang, Nannan Liu, Meimei Jiang, Guiyun Jia, Feng Wang, Ge Yang, Lingling Zhang, Jiangang Wang, Yang Fu, Yingjie Zhang
Ferroptosis is a new type of iron-dependent programmed cell death induced by lipid peroxidation. However, the underlying mechanisms and function in tumor therapy still remain undisclosed especially in post-transcription regulation. Here, we found that targeting AKT significantly induced GPX4 dependent ferroptosis and suppressed colorectal cancer growth both in vitro and in vivo. During this process, demethylase FTO was downregulated, which increased the m6A methylation level of GPX4, subsequently recognized by YTHDF2 and degraded...
December 15, 2023: Cell Death Discovery
https://read.qxmd.com/read/38086808/carmofur-prevents-cell-cycle-progression-by-reducing-e2f8-transcription-in-temozolomide-resistant-glioblastoma-cells
#14
JOURNAL ARTICLE
Cyntanna C Hawkins, Amber B Jones, Emily R Gordon, Yuvika Harsh, Julia K Ziebro, Christopher D Willey, Corinne Griguer, David K Crossman, Sara J Cooper, Sasanka Ramanadham, Ninh Doan, Anita B Hjelmeland
Sphingolipid metabolism is dysregulated in many cancers, allowing cells to evade apoptosis through increased sphingosine-1-phosphate (S1P) and decreased ceramides. Ceramidases hydrolyze ceramides to sphingosine, which is phosphorylated by sphingosine kinases to generate S1P. The S1P allows cells to evade apoptosis by shifting the equilibrium away from ceramides, which favor cell death. One tumor type that exhibits a shift in the sphingolipid balance towards S1P is glioblastoma (GBM), a highly aggressive brain tumor...
December 12, 2023: Cell Death Discovery
https://read.qxmd.com/read/38069256/farnesoid-x-receptor-agonist-gw4064-protects-lipopolysaccharide-induced-intestinal-epithelial-barrier-function-and-colorectal-tumorigenesis-signaling-through-the-%C3%AE-klotho-%C3%AE-klotho-fgfs-pathways-in-mice
#15
JOURNAL ARTICLE
Hsuan-Miao Liu, Zi-Yu Chang, Ching-Wei Yang, Hen-Hong Chang, Tzung-Yan Lee
The farnesoid X receptor (FXR)/βKlotho/fibroblast growth factors (FGFs) pathway is crucial for maintaining the intestinal barrier and preventing colorectal cancer (CRC). We used an FXR agonist, GW4064, and FXR-knockout (FXR-KO) mice to investigate the role of FXR/Klothos/FGFs pathways in lipopolysaccharide (LPS)-induced intestinal barrier dysfunction and colon carcinogenesis. The results showed that upregulation of FXR in enterocytes effectively ameliorated intestinal tight-junction markers (claudin1 and zonula occludens-1), inflammation, and bile acid levels, thereby protecting mice from intestinal barrier dysfunction and colon carcinogenesis...
November 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38063999/inherited-brca1-and-rnf43-pathogenic-variants-in-a-familial-colorectal-cancer-type-x-family
#16
JOURNAL ARTICLE
James M Chan, Mark Clendenning, Sharelle Joseland, Peter Georgeson, Khalid Mahmood, Jihoon E Joo, Romy Walker, Julia Como, Susan Preston, Shuyi Marci Chai, Yen Lin Chu, Aaron L Meyers, Bernard J Pope, David Duggan, J Lynn Fink, Finlay A Macrae, Christophe Rosty, Ingrid M Winship, Mark A Jenkins, Daniel D Buchanan
Genetic susceptibility to familial colorectal cancer (CRC), including for individuals classified as Familial Colorectal Cancer Type X (FCCTX), remains poorly understood. We describe a multi-generation CRC-affected family segregating pathogenic variants in both BRCA1, a gene associated with breast and ovarian cancer and RNF43, a gene associated with Serrated Polyposis Syndrome (SPS). A single family out of 105 families meeting the criteria for FCCTX (Amsterdam I family history criteria with mismatch repair (MMR)-proficient CRCs) recruited to the Australasian Colorectal Cancer Family Registry (ACCFR; 1998-2008) that underwent whole exome sequencing (WES), was selected for further testing...
December 8, 2023: Familial Cancer
https://read.qxmd.com/read/38042958/stromal-localization-of-inactive-cd8-t-cells-in-metastatic-mismatch-repair-deficient-colorectal-cancer
#17
JOURNAL ARTICLE
Emre Küçükköse, Matthijs J D Baars, Mojtaba Amini, Suzanna J Schraa, Evelien Floor, Guus M Bol, Inne H M Borel Rinkes, Jeanine M L Roodhart, Miriam Koopman, Jamila Laoukili, Onno Kranenburg, Yvonne Vercoulen
BACKGROUND: The determinants of metastasis in mismatch repair deficiency with high levels of microsatellite instability (MSI-H) in colorectal cancer (CRC) are poorly understood. Here, we hypothesized that distinct immune and stromal microenvironments in primary tumors may discriminate between non-metastatic MSI-H CRC and metastatic MSI-H CRC. METHODS: We profiled 46,727 single cells using high-plex imaging mass cytometry and analyzed both differential cell type abundance, and spatial distribution of fibroblasts and immune cells in primary CRC tumors with or without metastatic capacity...
December 2, 2023: British Journal of Cancer
https://read.qxmd.com/read/38031173/single-cell-analysis-unveils-activation-of-mast-cells-in-colorectal-cancer-microenvironment
#18
JOURNAL ARTICLE
Zhenyu Xie, Liaoran Niu, Gaozan Zheng, Kunli Du, Songchen Dai, Ruikai Li, Hanjun Dan, Lili Duan, Hongze Wu, Guangming Ren, Xinyu Dou, Fan Feng, Jian Zhang, Jianyong Zheng
The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs has not been conducted. This study used a multi-omics approach, integrating single-cell sequencing, spatial transcriptomics, and bulk tissue sequencing data to investigate the heterogeneity and impact of MCs in CRC. Five MC signature genes (TPSAB1, TPSB2, CPA3, HPGDS, and MS4A2) were identified, and their average expression was used as a marker of MCs. The MC density was found to be lower in CRC compared to normal tissue, but MCs in CRC demonstrated distinct activation features...
November 29, 2023: Cell & Bioscience
https://read.qxmd.com/read/38000379/cancer-screening-in-china-a-steep-road-from-evidence-to-implementation
#19
REVIEW
Changfa Xia, Partha Basu, Barnett S Kramer, He Li, Chunfeng Qu, Xue Qin Yu, Karen Canfell, Youlin Qiao, Bruce K Armstrong, Wanqing Chen
Cancer screening has the potential to decrease mortality from several common cancer types. The first cancer screening programme in China was initiated in 1958 and the Cancer High Incidence Fields established in the 1970s have provided an extensive source of information for national cancer screening programmes. From 2012 onwards, four ongoing national cancer screening programmes have targeted eight cancer types: cervical, breast, colorectal, lung, oesophageal, stomach, liver, and nasopharyngeal cancers. By synthesising evidence from pilot screening programmes and population-based studies for various screening tests, China has developed a series of cancer screening guidelines...
December 2023: Lancet. Public Health
https://read.qxmd.com/read/37958408/oligometastatic-disease-omd-the-classification-and-practical-review-of-prospective-trials
#20
REVIEW
Timur Izmailov, Sergey Ryzhkin, Gleb Borshchev, Sergei Boichuk
Oligometastatic disease (OMD) is currently known as an intermediate state of cancer, characterized by a limited number of systemic metastatic lesions for which local ablative therapy could be curative. Indeed, data from multiple clinical trials have illustrated an increase in overall survival (OS) for cancer patients when local ablative therapy was included in the systemic adjuvant therapy. Given that no driver and somatic mutations specific to OMD are currently established, the diagnosis of OMD is mainly based on the results of X-ray studies...
October 31, 2023: Cancers
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