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https://www.readbyqxmd.com/read/28039328/outcome-of-24%C3%A2-years-national-surveillance-in-different-hereditary-colorectal-cancer-subgroups-leading-to-more-individualised-surveillance
#1
Lars Joachim Lindberg, Steen Ladelund, Birgitte Lidegaard Frederiksen, Lars Smith-Hansen, Inge Bernstein
BACKGROUND: Individuals with hereditary non-polyposis colorectal cancer (HNPCC) have a high risk of colorectal cancer (CRC). The benefits of colonic surveillance in Lynch syndrome and Amsterdam-positive (familial CRC type X familial colorectal cancer type X (FCCTX)) families are clear; only the interval between colonoscopies is debated. The potential benefits for families not fulfilling the Amsterdam criteria are uncertain. The aim of this study was to compare the outcome of colonic surveillance in different hereditary subgroups and to evaluate the surveillance programmes...
December 30, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28002446/the-agaricus-blazei-based-mushroom-extract-andosan%C3%A2-protects-against-intestinal-tumorigenesis-in-the-a-j-min-mouse
#2
Geir Hetland, Dag M Eide, Jon M Tangen, Mads H Haugen, Mohammad R Mirlashari, Jan E Paulsen
BACKGROUND: The novel A/J Min/+ mouse, which is a model for human Familial Adenomatous Polyposis (FAP), develops spontaneously multiple adenocarcinomas in the colon as well as in the small intestine. Agaricus blazei Murill (AbM) is an edible Basidiomycetes mushroom that has been used in traditional medicine against cancer and other diseases. The mushroom contains immunomodulating β-glucans and is shown to have antitumor effects in murine cancer models. Andosan™ is a water extract based on AbM (82%), but it also contains the medicinal Basidiomycetes mushrooms Hericeum erinaceus and Grifola frondosa...
2016: PloS One
https://www.readbyqxmd.com/read/27977020/dna-methylation-identifies-loci-distinguishing-hereditary-nonpolyposis-colorectal-cancer-without-germ-line-mlh1-msh2-mutation-from-sporadic-colorectal-cancer
#3
Chung-Hsing Chen, Shih Sheng Jiang, Ling-Ling Hsieh, Reiping Tang, Chao A Hsiung, Hui-Ju Tsai, I-Shou Chang
OBJECTIVES: Roughly half of hereditary nonpolyposis colorectal cancer (HNPCC) cases are Lynch syndrome and exhibit germ-line mutations in DNA mismatch repair (MMR) genes; the other half are familial colorectal cancer (CRC) type X (FCCTX) and are MMR proficient. About 70% of Lynch syndrome tumors have germ-line MLH1 or MSH2 mutations. The clinical presentation, histopathological features, and carcinogenesis of FCCTX resemble those of sporadic MMR-proficient colorectal tumors. It is of interest to obtain biomarkers that distinguish FCCTX from sporadic microsatellite stable (MSS) CRC, to develop preventive strategies...
December 15, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27938574/-effects-of-neoadjuvant-chemoradiotherapy-on-the-rates-of-sphincter-preserving-surgery-in-lower-rectal-cancer-and-analysis-of-their-prognostic-factors
#4
X J Wang, P Chi, H M Lin, X R Lu, Y Huang, Z B Xu, S H Huang, Y W Sun, D X Ye
Objectives: To identify independent factors of sphincter preserving surgery, and to evaluated whether preoperative chemoradiotherapy (CRT) improves the sphincter preservation rate for lower rectal cancers. Methods: A total of 541 consecutive patients who underwent curative surgery for locally advanced rectal cancer (cT3-4Nx or cTxN+ ) within 6 cm of the anal verge with or without neoadjuvant CRT in Department of Colorectal Surgery, Union Hospital, Fujian Medical University between September 2000 and September 2013 were reviewed...
1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27903750/nuclear-export-of-ubiquitinated-proteins-determines-the-sensitivity-of-colorectal-cancer-to-proteasome-inhibitor
#5
Tingyu Wu, Wei Chen, Yongwang Zhong, Xiaodan Hou, Shengyun Fang, Chen-Ying Liu, Guanghui Wang, Tong Yu, Yu-Yang Huang, Xuesong Ouyang, Henry Q X Li, Long Cui, Yili Yang
Although proteasome inhibitors such as Bortezomib had significant therapeutic effects in multiple myeloma and mantel cell lymphoma, they exhibited minimal clinical activity as a mono-therapy for solid tumors, including colorectal cancer. We found in the present study that proteasome inhibition induced a remarkable nuclear exportation of ubiquitinated proteins. Inhibition of CRM1, the nuclear export carrier protein, hampered protein export and synergistically enhanced the cytotoxic action of Bortezomib on colon cancer cells containing wild type p53, which underwent G2/M cell cycle block and apoptosis...
November 30, 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27894406/vincristine-promotes-migration-and-invasion-of-colorectal-cancer-hct116-cells-through-rhoa-rock-myosin-light-chain-pathway
#6
X Jin, K Liu, B Jiao, X Wang, S Huang, W Ren, K Zhao
Vincristine is an antitumor vinca alkaloid isolated from vinca rosea, and is a medication used to treat a number of types of cancer. In this study, we investigated the impact of vincristine on oncogenic phenotypes of human colorectal cancer HCT116 cells. MTT assay demonstrated that vincristine showed a obviously inhibitory effect on cell growth compared to non-treated cells. However, Transwell assay showed that vincristine promoted migration and invasion of HCT116 cells in vitro in a concentration-dependent manner between 0...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27801343/-a-retrospective-case-control-study-of-immunoglobulin-g4-related-disease-combined-with-malignancy
#7
Y L Feng, D Wu, S Y Zhang, X Wu, H J Shu, A M Yang, J M Qian
IgG4-related disease (IgG4-RD) has been proved to be associated with malignancy.The incidence and risk factors of malignancy development in IgG4-RD were not clear. Nine IgG4-RD patients with malignancies and 27 IgG4-RD control cases were analyzed for risk factors and clinical features. The incidence of malignancy in IgG4-RD was 3.3%, higher than age-controlled general population. Smoking history was significantly more common in patients with malignancies than in the control group (9/9 vs 16/27, P<0.05). A total of 6/9 malignancies occurred within the first year after the diagnosis of IgG4-RD...
November 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27733754/prognostic-value-of-zinc-finger-protein-x-linked-in-patients-with-solid-tumors
#8
Chao Dai, Qing Dong, Qi Lu, Fang T Liu, Zheng M Zhu
INTRODUCTION: Many studies recently suggested that Zinc-finger protein X-linked (ZFX) acted as a novel oncoprotein in various malignancies. It was frequently overexpressed in cancerous tissues and the high expression of ZFX may have important clinical value. This meta-analysis aims to investigate the prognostic value of ZFX as a biomarker of solid cancers. EVIDENCE ACQUISITION: We search for multiple databases, including Pubmed, Springer, Web of Science, CNKI from 1996 to Sep...
February 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/27730471/monitoring-tumor-response-after-liposomal-doxorubicin-in-combination-with-liposomal-vinorelbine-treatment-using-3-deoxy-3-18-f-fluorothymidine-pet
#9
Chun-Yi Wu, Jo-Hsin Tang, Pei-Chia Chan, Jia-Je Li, Ming-Hsien Lin, Chih-Chieh Shen, Ren-Shyan Liu, Hsin-Ell Wang
PURPOSE: Surgical resection is the standard treatment for localized colorectal cancer, which is the most common type of gastrointestinal cancer. However, over 40 % cases are diagnosed metastasized and apparently inoperable. Systemic chemotherapy provides an alternative to these patients. This study aims to evaluate the therapeutic potential of liposomal doxorubicin (lipoDox) in combination with liposomal vinorelbine (lipoVNB) in a CT-26 colon carcinoma-bearing mouse model. PROCEDURES: The in vitro cytotoxicity of Dox and VNB on CT-26 cancer cells was determined by MTT and colony formation assays...
October 11, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27690719/gold-nanoparticles-in-combination-with-megavoltage-radiation-energy-increased-radiosensitization-and-apoptosis-in-colon-cancer-ht-29-cells
#10
Alihossein Saberi, Daryoush Shahbazi-Gahrouei, Mahdi Abbasian, Mehrafarin Fesharaki, Azam Baharlouei, Zahra Arab-Bafrani
PURPOSE: Gold nanoparticles (GNPs) act as a radiosensitizer in radiation therapy. However, recent studies have shown contradictory evidence in terms of radiosensitization in the presence of GNPs combined with x-ray megavoltage energy (MV) on different cell types. In this study, the effect of GNPs on radiosensitization enhancement of HT-29 human colorectal cancer cells at MV x-ray energy was evaluated. MATERIAL AND METHODS: The cytotoxicity and radiosensitization of GNPs were evaluated in HT-29 human colorectal cancer cells by MTS-assay and multiple MTS-assay, respectively...
October 3, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27682134/broad-detection-of-alterations-predicted-to-confer-lack-of-benefit-from-egfr-antibodies-or-sensitivity-to-targeted-therapy-in-advanced-colorectal-cancer
#11
Andrew Rankin, Samuel J Klempner, Rachel Erlich, James X Sun, Axel Grothey, Marwan Fakih, Thomas J George, Jeeyun Lee, Jeffrey S Ross, Philip J Stephens, Vincent A Miller, Siraj M Ali, Alexa B Schrock
INTRODUCTION: A KRAS mutation represented the first genomic biomarker to predict lack of benefit from anti-epidermal growth factor receptor (EGFR) antibody therapy in advanced colorectal cancer (CRC). Expanded RAS testing has further refined the treatment approach, but understanding of genomic alterations underlying primary and acquired resistance is limited and further study is needed. MATERIALS AND METHODS: We prospectively analyzed 4,422 clinical samples from patients with advanced CRC, using hybrid-capture based comprehensive genomic profiling (CGP) at the request of the individual treating physicians...
September 28, 2016: Oncologist
https://www.readbyqxmd.com/read/27671100/clinicopathological-differences-between-familial-colorectal-cancer-type-x-and-sporadic-cancer-in-an-isolated-area-of-spain
#12
V Medina-Arana, A Rahy-Martín, L Delgado-Plasencia, A Martínez-Riera, D León-Ayllón, D Rodríguez-Castellano, A Bravo-Gutiérrez, A Fernández-Peralta, J J González-Aguilera
AIM: Very few studies have compared the epidemiological characteristics of patients with familial colorectal cancer Type X (FCCTX) with those of sporadic colorectal cancer (S-CRC). The aim of this study was to compare clinicopathological characteristics and survival between FCCTX and S-CRC in patients from a historically isolated geographical region. METHOD: A retrospective study was carried out of patients with S-CRC and FCCTX treated in the Canary Islands. Family and personal history of colorectal cancer (CRC) were recorded, together with genetic (microsatellite instability), immunohistochemical and clinical variables...
November 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27573888/non-thermal-gas-plasma-induced-endoplasmic-reticulum-stress-mediates-apoptosis-in-human-colon-cancer-cells
#13
Madduma Hewage Susara Ruwan Kumara, Mei Jing Piao, Kyoung Ah Kang, Yea Seong Ryu, Jeong Eon Park, Kristina Shilnikova, Jin Oh Jo, Young Sun Mok, Jennifer H Shin, Yeonsoo Park, Seong Bong Kim, Suk Jae Yoo, Jin Won Hyun
Colorectal cancer is a common type of tumor among both men and women worldwide. Conventional remedies such as chemotherapies pose the risk of side‑effects, and in many cases cancer cells develop chemoresistance to these treatments. Non‑thermal gas plasma (NTGP) was recently identified as a potential tool for cancer treatment. In this study, we investigated the potential use of NTGP to control SNUC5 human colon carcinoma cells. We hypothesized that NTGP would generate reactive oxygen species (ROS) in these cells, resulting in induction of endoplasmic reticulum (ER) stress...
October 2016: Oncology Reports
https://www.readbyqxmd.com/read/27399917/expression-of-the-chemokine-cxcl14-and-cetuximab-dependent-tumour-suppression-in-head-and-neck-squamous-cell-carcinoma
#14
T Kondo, S Ozawa, T Ikoma, X-Y Yang, K Kanamori, K Suzuki, H Iwabuchi, Y Maehata, C Miyamoto, T Taguchi, T Kiyono, E Kubota, R-I Hata
Cetuximab, a monoclonal antibody against the epidermal growth factor receptor (EGFR), has been successfully used to treat some patients with colorectal cancer and those with head and neck squamous cell carcinoma (HNSCC). For the effective treatment, it is essential to first identify cetuximab-responsive patients. The level of EGFR expression and/or the presence of mutations in signalling molecules downstream of the EGFR pathway have been reported to be determining factors for cetuximab responsiveness in colorectal cancer patients; however, limited data have been reported for HNSCC patients...
2016: Oncogenesis
https://www.readbyqxmd.com/read/27330310/the-prognostic-role-of-serum-c-x-c-chemokine-receptor-type-4-in-patients-with-metastatic-or-recurrent-colorectal-cancer
#15
Yoon Ji Choi, Won Jin Chang, Sang Won Shin, Kyong Hwa Park, Seung Tae Kim, Yeul Hong Kim
BACKGROUND: C-X-C chemokine receptor type 4 (CXCR4) is involved in tumor progression including angiogenesis, metastasis, and survival. However, whether serum CXCR4 levels in metastatic or recurrent colorectal cancer have a prognostic role, have not been evaluated. METHODS: We analyzed serum samples from 55 patients with advanced colorectal cancer diagnosed between March 2008 and July 2011. Serum CXCR4 levels were quantified by a commercially available enzyme-linked immunosorbent assay (ELISA) kit...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27309477/transforming-growth-factor-beta-induced-factor-2-linked-x-tgif2lx-regulates-two-morphogenesis-genes-nir1-and-nir2-in-human-colorectal
#16
Gholam Reza Mobini, Mohammad Hossein Ghahremani, Saeid Amanpour, Ahmad Reza Dehpour, Abolfazl Akbari, Seyed Mojtaba Hoseiniharouni, Samad Muhammadnejad, Maryam Sheikhzade, Hoda Abedkhojasteh, Masoumeh Mohebi, Manzar Bolhassani, Mansour Heidari
A member of homeodomain protein namely TGIF2LX has been implicated as a tumor suppressor gene in human malignancy as well as in spermatogenesis. However, to our knowledge, dynamic functional evidence of the TGIF2LX has not yet been provided. The aim of the present study was to investigate the human TGIF2LX target gene(s) using a cDNA-AFLP as a differential display method. A pEGFP-TGIF2LX construct containing the wild-type TGIF2LX cDNA was stably transfected into SW48 cells. UV microscopic analysis and Real-time RT-PCR were used to confirm TGIF2LX expression...
May 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27301141/-serrated-colorectal-adenocarcinoma
#17
A M Nechipay, K V Shishkin, M V Zobnina, L M Cherkasova, V A Krivopuskov
THE AIM: To present a clinical case of serrated colon adenocarcinoma. To demonstrate morphological and genetic features of these tumors and to determine their clinical management. KEY POINTS: Described case shows diagnostics of serrated colon adenocarcinoma. A 67-year-old woman presented for colonoscopy because of long constipation besides abdominal pain and distention have appeared recently. Colonoscopy was performed and she was found to have a 3.0 x 3.0-cm tumor next to hepatic flexure and pedunculated 1...
2016: Experimental & Clinical Gastroenterology
https://www.readbyqxmd.com/read/27270424/the-fen1-l209p-mutation-interferes-with-long-patch-base-excision-repair-and-induces-cellular-transformation
#18
H Sun, L He, H Wu, F Pan, X Wu, J Zhao, Z Hu, C Sekhar, H Li, L Zheng, H Chen, B H Shen, Z Guo
Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that has a critical role in maintaining human genome stability. FEN1 mutations have been detected in human cancer specimens and have been suggested to cause genomic instability and cancer predisposition. However, the exact relationship between FEN1 deficiency and cancer susceptibility remains unclear. In the current work, we report a novel colorectal cancer-associated FEN1 mutation, L209P. This mutant protein lacks the FEN, exonuclease (EXO) and gap endonuclease (GEN) activities of FEN1 but retains DNA-binding affinity...
January 12, 2017: Oncogene
https://www.readbyqxmd.com/read/27270421/integrated-genomic-analysis-of-colorectal-cancer-progression-reveals-activation-of-egfr-through-demethylation-of-the-ereg-promoter
#19
X Qu, T Sandmann, H Frierson, L Fu, E Fuentes, K Walter, K Okrah, C Rumpel, C Moskaluk, S Lu, Y Wang, R Bourgon, E Penuel, A Pirzkall, L Amler, M R Lackner, J Tabernero, G M Hampton, O Kabbarah
Key molecular drivers that underlie transformation of colonic epithelium into colorectal adenocarcinoma (CRC) are well described. However, the mechanisms through which clinically targeted pathways are activated during CRC progression have yet to be elucidated. Here, we used an integrative genomics approach to examine CRC progression. We used laser capture microdissection to isolate colonic crypt cells, differentiated surface epithelium, adenomas, carcinomas and metastases, and used gene expression profiling to identify pathways that were differentially expressed between the different cell types...
December 15, 2016: Oncogene
https://www.readbyqxmd.com/read/27239121/colorectal-cancer-screening-in-countries-of-european-council-outside-of-the-eu-28
#20
Emma Altobelli, Francesco D'Aloisio, Paolo Matteo Angeletti
AIM: To provide an update on colorectal cancer (CRC) screening programmes in non-European Union (EU)-28 Council of Europe member states as of December 2015. METHODS: The mission of the Council of Europe is to protect and promote human rights in its 47 member countries. Its 19 non-EU member states are Albania, Andorra, Armenia, Azerbaijan, Bosnia and Herzegovina, Republika Srpska, Georgia, Iceland, Liechtenstein, Republic of Moldova, Monaco, Montenegro, Norway, Russian Federation, San Marino, Serbia, Switzerland, FYR of Macedonia, Turkey, and Ukraine (EU-19)...
May 28, 2016: World Journal of Gastroenterology: WJG
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