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Colorectal cancer type-x

Chao Dai, Qing Dong, Qi Lu, Fangteng Liu, Zhengming Zhu
BACKGROUND: Many studies recently suggested that Zinc-finger protein X-linked (ZFX) acted as a novel oncoprotein in various malignancies. It was frequently overexpressed in cancerous tissues and the high expression of ZFX may have important clinical value. This meta-analysis aims to investigate the prognostic value of ZFX as a biomarker of solid cancers. METHODS: We search for multiple databases, including Pubmed, Springer, Web of Science, CNKI from 1996 to Sep...
October 12, 2016: Minerva Chirurgica
Chun-Yi Wu, Jo-Hsin Tang, Pei-Chia Chan, Jia-Je Li, Ming-Hsien Lin, Chih-Chieh Shen, Ren-Shyan Liu, Hsin-Ell Wang
PURPOSE: Surgical resection is the standard treatment for localized colorectal cancer, which is the most common type of gastrointestinal cancer. However, over 40 % cases are diagnosed metastasized and apparently inoperable. Systemic chemotherapy provides an alternative to these patients. This study aims to evaluate the therapeutic potential of liposomal doxorubicin (lipoDox) in combination with liposomal vinorelbine (lipoVNB) in a CT-26 colon carcinoma-bearing mouse model. PROCEDURES: The in vitro cytotoxicity of Dox and VNB on CT-26 cancer cells was determined by MTT and colony formation assays...
October 11, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Alihossein Saberi, Daryoush Shahbazi-Gahrouei, Mahdi Abbasian, Mehrafarin Fesharaki, Azam Baharlouei, Zahra Arab-Bafrani
PURPOSE: Gold nanoparticles (GNPs) act as a radiosensitizer in radiation therapy. However, recent studies have shown contradictory evidence in terms of radiosensitization in the presence of GNPs combined with x-ray megavoltage energy (MV) on different cell types. In this study, the effect of GNPs on radiosensitization enhancement of HT-29 human colorectal cancer cells at MV x-ray energy was evaluated. MATERIAL AND METHODS: The cytotoxicity and radiosensitization of GNPs were evaluated in HT-29 human colorectal cancer cells by MTS-assay and multiple MTS-assay, respectively...
October 3, 2016: International Journal of Radiation Biology
Andrew Rankin, Samuel J Klempner, Rachel Erlich, James X Sun, Axel Grothey, Marwan Fakih, Thomas J George, Jeeyun Lee, Jeffrey S Ross, Philip J Stephens, Vincent A Miller, Siraj M Ali, Alexa B Schrock
INTRODUCTION: A KRAS mutation represented the first genomic biomarker to predict lack of benefit from anti-epidermal growth factor receptor (EGFR) antibody therapy in advanced colorectal cancer (CRC). Expanded RAS testing has further refined the treatment approach, but understanding of genomic alterations underlying primary and acquired resistance is limited and further study is needed. MATERIALS AND METHODS: We prospectively analyzed 4,422 clinical samples from patients with advanced CRC, using hybrid-capture based comprehensive genomic profiling (CGP) at the request of the individual treating physicians...
September 28, 2016: Oncologist
V Medina-Arana, A Rahy-Martín, L Delgado-Plasencia, A Martínez-Riera, D León-Ayllón, D Rodríguez-Castellano, A Bravo-Gutiérrez, A Fernández-Peralta, J J González-Aguilera
AIM: Very few studies have compared epidemiological characteristics of patients with Familial Colorectal Cancer Type X (FCCTX) with sporadic colorectal cancer (S-CRC). The aim of the study was to compare clinicopathological characteristics and survival in FCCTX and S-CRC patients from a historically isolated geographic region. METHOD: A retrospective study was carried out of patients with S-CRC and FCCTX treated in the Canary Islands. Family and personal history of colorectal cancer (CRC), genetic (microsatellite instability), immunohistochemical and clinical variables were recorded...
September 27, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Madduma Hewage Susara Ruwan Kumara, Mei Jing Piao, Kyoung Ah Kang, Yea Seong Ryu, Jeong Eon Park, Kristina Shilnikova, Jin Oh Jo, Young Sun Mok, Jennifer H Shin, Yeonsoo Park, Seong Bong Kim, Suk Jae Yoo, Jin Won Hyun
Colorectal cancer is a common type of tumor among both men and women worldwide. Conventional remedies such as chemotherapies pose the risk of side‑effects, and in many cases cancer cells develop chemoresistance to these treatments. Non‑thermal gas plasma (NTGP) was recently identified as a potential tool for cancer treatment. In this study, we investigated the potential use of NTGP to control SNUC5 human colon carcinoma cells. We hypothesized that NTGP would generate reactive oxygen species (ROS) in these cells, resulting in induction of endoplasmic reticulum (ER) stress...
October 2016: Oncology Reports
T Kondo, S Ozawa, T Ikoma, X-Y Yang, K Kanamori, K Suzuki, H Iwabuchi, Y Maehata, C Miyamoto, T Taguchi, T Kiyono, E Kubota, R-I Hata
Cetuximab, a monoclonal antibody against the epidermal growth factor receptor (EGFR), has been successfully used to treat some patients with colorectal cancer and those with head and neck squamous cell carcinoma (HNSCC). For the effective treatment, it is essential to first identify cetuximab-responsive patients. The level of EGFR expression and/or the presence of mutations in signalling molecules downstream of the EGFR pathway have been reported to be determining factors for cetuximab responsiveness in colorectal cancer patients; however, limited data have been reported for HNSCC patients...
2016: Oncogenesis
Yoon Ji Choi, Won Jin Chang, Sang Won Shin, Kyong Hwa Park, Seung Tae Kim, Yeul Hong Kim
BACKGROUND: C-X-C chemokine receptor type 4 (CXCR4) is involved in tumor progression including angiogenesis, metastasis, and survival. However, whether serum CXCR4 levels in metastatic or recurrent colorectal cancer have a prognostic role, have not been evaluated. METHODS: We analyzed serum samples from 55 patients with advanced colorectal cancer diagnosed between March 2008 and July 2011. Serum CXCR4 levels were quantified by a commercially available enzyme-linked immunosorbent assay (ELISA) kit...
2016: OncoTargets and Therapy
Gholam Reza Mobini, Mohammad Hossein Ghahremani, Saeid Amanpour, Ahmad Reza Dehpour, Abolfazl Akbari, Seyed Mojtaba Hoseiniharouni, Samad Muhammadnejad, Maryam Sheikhzade, Hoda Abedkhojasteh, Masoumeh Mohebi, Manzar Bolhassani, Mansour Heidari
A member of homeodomain protein namely TGIF2LX has been implicated as a tumor suppressor gene in human malignancy as well as in spermatogenesis. However, to our knowledge, dynamic functional evidence of the TGIF2LX has not yet been provided. The aim of the present study was to investigate the human TGIF2LX target gene(s) using a cDNA-AFLP as a differential display method. A pEGFP-TGIF2LX construct containing the wild-type TGIF2LX cDNA was stably transfected into SW48 cells. UV microscopic analysis and Real-time RT-PCR were used to confirm TGIF2LX expression...
May 2016: Acta Medica Iranica
A M Nechipay, K V Shishkin, M V Zobnina, L M Cherkasova, V A Krivopuskov
THE AIM: To present a clinical case of serrated colon adenocarcinoma. To demonstrate morphological and genetic features of these tumors and to determine their clinical management. KEY POINTS: Described case shows diagnostics of serrated colon adenocarcinoma. A 67-year-old woman presented for colonoscopy because of long constipation besides abdominal pain and distention have appeared recently. Colonoscopy was performed and she was found to have a 3.0 x 3.0-cm tumor next to hepatic flexure and pedunculated 1...
2016: Experimental & Clinical Gastroenterology
H Sun, L He, H Wu, F Pan, X Wu, J Zhao, Z Hu, C Sekhar, H Li, L Zheng, H Chen, B H Shen, Z Guo
Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that has a critical role in maintaining human genome stability. FEN1 mutations have been detected in human cancer specimens and have been suggested to cause genomic instability and cancer predisposition. However, the exact relationship between FEN1 deficiency and cancer susceptibility remains unclear. In the current work, we report a novel colorectal cancer-associated FEN1 mutation, L209P. This mutant protein lacks the FEN, exonuclease (EXO) and gap endonuclease (GEN) activities of FEN1 but retains DNA-binding affinity...
June 6, 2016: Oncogene
X Qu, T Sandmann, H Frierson, L Fu, E Fuentes, K Walter, K Okrah, C Rumpel, C Moskaluk, S Lu, Y Wang, R Bourgon, E Penuel, A Pirzkall, L Amler, M R Lackner, J Tabenero, G M Hampton, O Kabbarah
Key molecular drivers that underlie transformation of colonic epithelium into colorectal adenocarcinoma (CRC) are well described. However, the mechanisms through which clinically targeted pathways are activated during CRC progression have yet to be elucidated. Here, we used an integrative genomics approach to examine CRC progression. We used laser capture microdissection to isolate colonic crypt cells, differentiated surface epithelium, adenomas, carcinomas and metastases, and used gene expression profiling to identify pathways that were differentially expressed between the different cell types...
June 6, 2016: Oncogene
Emma Altobelli, Francesco D'Aloisio, Paolo Matteo Angeletti
AIM: To provide an update on colorectal cancer (CRC) screening programmes in non-European Union (EU)-28 Council of Europe member states as of December 2015. METHODS: The mission of the Council of Europe is to protect and promote human rights in its 47 member countries. Its 19 non-EU member states are Albania, Andorra, Armenia, Azerbaijan, Bosnia and Herzegovina, Republika Srpska, Georgia, Iceland, Liechtenstein, Republic of Moldova, Monaco, Montenegro, Norway, Russian Federation, San Marino, Serbia, Switzerland, FYR of Macedonia, Turkey, and Ukraine (EU-19)...
May 28, 2016: World Journal of Gastroenterology: WJG
Jinfeng Han, Zhongmin Liu, Nanya Wang, Weiyun Pan
MicroRNA-874 (miR-874) is downregulated and acts as a tumor suppressor in several types of cancers, whereas the biological function of miR-874 in colorectal cancer (CRC) remains unclear. The aims of the present study were to investigate the clinical significance, biological effects, and the underlying mechanisms of miR-874 in CRC. Reverse transcription-quantitative PCR (RT-qPCR) was used to detect miR-874 expression in CRC cell lines and tissue samples. MTT and colony formation assays and flow cytometry were performed to analyze the effects of miR-874 expression on growth, apoptosis and the chemoresistance of CRC cells...
July 2016: Oncology Reports
Tetsuro Isozaki, Mayumi Fujita, Shigeru Yamada, Kaori Imadome, Yoshimi Shoji, Takeshi Yasuda, Fumiaki Nakayama, Takashi Imai, Hisahiro Matsubara
C-ion radiotherapy is associated with improved local control and survival in several types of tumors. Although C-ion irradiation is widely reported to effectively induce DNA damage in tumor cells, the effects of irradiation on proteins, such as protein stability or degradation in response to radiation stress, remain unknown. We aimed to compare the effects of C-ion and X-ray irradiation focusing on the cellular accumulation of ubiquitylated proteins. Cells from two human colorectal cancer cell lines, SW620 and SW480, were subjected to C-ion or X-ray irradiation and determination of ubiquitylated protein levels...
July 2016: International Journal of Oncology
H X Peng, X Xu, R Yang, Y M Chu, D M Yang, Y Xu, F L Zhou, W Z Ma, X J Zhang, M Guan, Z H Yang, Z D Jin
Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese patients. Therefore, the present study aimed to describe the pathogenic association between three important MLH1 polymorphisms and SCRC in the Chinese population. Peripheral blood samples from 156 SCRC patients and 311 healthy controls were collected...
2016: Genetics and Molecular Research: GMR
X J Wang, M Xia, W P Bi
Dysregulation of miRNAs is associated with cancer development and progression. For example, aberrant expression of miR-874 has been found in some types of cancer. However, miR-874 expression and its clinical significance in colorectal cancer (CRC) have not yet been explored. The aim of the current study was to explore the effects of miR-874 in CRC tumorigenesis and development. Quantitative reverse-transcription PCR was performed to evaluate miR-874 levels in CRC cell lines and in 135 pairs of primary human CRC specimens and adjacent noncancerous tissues...
2016: Genetics and Molecular Research: GMR
Gertrud Knoll, Sebastian Bittner, Maria Kurz, Jonathan Jantsch, Martin Ehrenschwender
The capacity of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to selectively induce cell death in malignant cells triggered numerous attempts for therapeutic exploitation. In clinical trials, however, TRAIL did not live up to the expectations, as tumors exhibit high rates of TRAIL resistance in vivo. Response to anti-cancer therapy is determined not only by cancer cell intrinsic factors (e.g. oncogenic mutations), but also modulated by extrinsic factors such as the hypoxic tumor microenvironment...
May 6, 2016: Oncotarget
Buyun Kim, Jaewoo Yoon, Seong Woo Yoon, Byoungduck Park
Cysteine X cysteine (CXC) chemokine receptor 4 (CXCR4) and C-X-C motif chemokine 12 (CXCL12) were originally identified as chemoattractants between immune cells and sites of inflammation. Since studies have validated an increased level of CXCL12 and its receptor in patients with colorectal cancers, CXCL12/CXCR4 axis has been considered as a valuable marker of cancer metastasis. Therefore, identification of CXCR4 inhibitors has great potential to abrogate tumor metastasis. Onbaekwon (OBW) is a complex herbal formula that is derived from the literature of traditional Korean medicine Dongeuibogam In this study, we demonstrated that OBW suppressed CXCR4 expression in various cancer cell types in a concentration- and time-dependent manner...
May 9, 2016: Integrative Cancer Therapies
Lisa Lutz, Ingrid Coutiño Fitzner, Theresa Ahrens, Anna-Lena Geißler, Frank Makowiec, Ulrich T Hopt, Lioudmila Bogatyreva, Dieter Hauschke, Martin Werner, Silke Lassmann
Little is known about histone modifiers and histone marks in colorectal cancers (CRC). The present study therefore addressed the role of histone acetylation and histone deacetylases (HDAC) in CRCs in situ and in vitro. Immunohistochemistry of primary CRCs (n=47) revealed that selected histone marks were frequently present (H3K4me3: 100%; H3K9me3: 77%; H3K9ac: 75%), partially displayed intratumoral heterogeneity (H3K9me3; H3K9ac) and were significantly linked to higher pT category (H3K9me3: p=0.023; H3K9ac: p=0...
2016: American Journal of Cancer Research
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