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Hepatic spindle cell neoplasms

Shao-Yan Xu, Hua Guo, Yan Shen, Ke Sun, Hai-Yang Xie, Lin Zhou, Shu-Sen Zheng, Wei-Lin Wang
BACKGROUND: Schwannomas are mesenchymal neoplasms that arise from Schwann cells with low malignant potential. Schwannomas originating from the porta hepatis or intra-abdominal organs are extremely rare. To our knowledge, multiple schwannomas synchronously occurring in the porta hepatis, liver, and gallbladder have not been reported so far and we first report one in the present case. CASE SUMMARY: A 31-year-old female was referred to our hospital because of repeated abdomen discomfort, slight abdominal distension, and occasional abdominal pain for seven years...
August 2016: Medicine (Baltimore)
Kyu Ho Lee, Mussin Nadiar Maratovich, Kyoung-Bun Lee
Undifferentiated embryonal sarcoma of the liver (UESL) is rare primary hepatic sarcoma and is known to occur in pediatric patients. This case is the UESL occurred in a 51-year old male patient. Multilocular cystic lesion was composed of primitive spindle cells without specific differentiation. This rare case would help to review differential diagnosis of primary sarcoma in liver and cystic neoplasm of the liver.
June 2016: Clinical and Molecular Hepatology
Lei Liu, Yingqiao Zhu, Dongxuan Wang, Changbin Yang, Q I Zhang, Xiukun Li, Yang Bai
Gastrointestinal stromal tumors (GIST) are mesenchymal neoplasms of the gastrointestinal tract (GI) that are defined, in part, by the expression of CD117, a c-Kit proto-oncogene protein. GISTs emerge outside of the GI at a very low frequency, typically in a single organ or location. GISTs that occasionally emerge outside of the GI are classified as extra-gastrointestinal stromal tumors (EGIST). The present study reports an extremely rare case of EGIST detected in the pancreas and the liver. The pancreatic and liver tumors were 4...
May 2016: Oncology Letters
Fernando Cano-García, Amado de Jesús Athie-Athie, Jaime I García-Gómez, Fredy Chablé-Montero, Jorge Albores-Saavedra
 We report an example of a cystic hepatic angiosarcoma that to our knowledge has not been previously described. The patient was a 70 year old woman who was admitted to the emergency room because of hypovolemic shock. A computed tomography showed four heterogeneous hepatic cystic masses varying from 2.5 to 11.2 cm; one of these with rupture and formation of a subcapsular hematoma. The cyst wall was lined by several layers of neoplastic epithelioid and spindle shaped endothelial cells that in some areas extended to the underlying stroma...
March 2016: Annals of Hepatology
Zu-Sen Wang, Lin Xu, Lin Ma, Meng-Qi Song, Li-Qun Wu, Xuan Zhou
BACKGROUND: The objective of the study was to explore the clinical expression, radiological and pathological features, differential diagnosis, and biological behavior of a clear cell myomelanocytic tumor. In a case involving a clear cell myomelanocytic tumor located in the hepatic falciform ligament, we evaluated clinical expression, radiological characteristics, histopathology, immunohistochemistry, and biological behavior; we also reviewed the relevant literature. CASE PRESENTATION: Clear cell myomelanocytic tumor is a benign soft-tissue neoplasm that often occurs in women, and is expressed as a painless mass...
2015: BMC Cancer
Anna Silvanto, Nariman D Karanjia, Izhar N Bagwan
Extrapleural solitary fibrous tumor (SFT) is an uncommon mesenchymal neoplasm, presenting most commonly in the intrathoracic sites but which has been reported at numerous extrathoracic locations. The majority of intra-thoracic SFTs are benign, but 10%-15% behave aggressively. We report a case of primary hepatic SFT with histologically benign and malignant areas. A 65-year-old man underwent an abdominal CT scan following a cerebrovascular accident, which demonstrated a sharply demarcated large liver mass with a heterogenous enhancing area and occupying most of the left lobe of the liver...
December 2015: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Long-Hai Feng, Hui Dong, Yu-Yao Zhu, Wen-Ming Cong
BACKGROUND: Primary hepatic solitary fibrous tumor is a rare neoplasm that originates in the submesothelial tissue of the liver and is frequently misdiagnosed because of its rarity and unfamiliar characteristics. AIM: To analyze, summarize and update the clinical and pathological features of primary hepatic solitary fibrous tumor. METHODS: We systematically extract the clinical data of 4 cases from the relevant medical records, analyze the macroscopic, histological and immunohistochemical features and review the 59 previously reported cases in the English literatures...
December 2015: Pathology, Research and Practice
Alessandro Ginori, Francesco Scaramuzzino, Stefania Marsili, Sergio Tripodi
Gastrointestinal stromal tumor (GIST) metastases are found most commonly in the liver, on average 16 to 38 months after resection of the primary tumor, even if some delayed hepatic metastases from GISTs have been described. We report a case of a man with a giant liver mass at computed tomography scan. In September 1984, the patient had undergone resection of a duodenal tumor, diagnosed as schwannoma. A liver biopsy revealed a neoplasm composed of epithelioid and spindled cells, immunohistochemically positive to c-kit and Dog-1...
June 2015: International Journal of Surgical Pathology
Zu-Hua Gao
Primary mesenchymal tumors represent a rare subset of hepatic lesions with overlapping spindle cell morphology. These lesions pose unique diagnostic challenges for pathologists as they are infrequently seen in general practice and can be easily mistaken for their benign counterparts or mimickers. In the current era of personalized medicine, precise pathologic diagnosis of these lesions is critically important to guide targeted therapy. This expectation is difficult to meet when pathologists face uncommon lesions outside their scope of experience...
October 2014: Pathology
Wael Hassan, Junko Nishi, Shinjiro Tomiyasu, Tadahito Urakado, Katsuki Haraoka, Tuyoshi Yamanaka, Shigetoshi Fujiyama, Takaaki Ito
Myoepithelial carcinoma is a well-known tumor of salivary gland, representing 1% of all salivary gland tumors. They have also been reported in other sites as skin/soft tissue, breast and lung. This paper reports a rare case of primary myoepithelial carcinoma in the liver, as well as discusses the findings of immunohistochemistry. The clinical manifestations, imaging characteristics, and histopathological changes of myoepithelial carcinoma in this case were described. The patient was a 33 years old female presented with a cystic tumor in the right lobe of the liver...
2014: International Journal of Clinical and Experimental Pathology
Catherine E Hagen, Michal Kamionek, David S McKinsey, Joseph Misdraji
Syphilis, a sexually transmitted infection caused by the spirochete Treponema pallidum, has seen a resurgence since 2001, particularly in men who have sex with men. Syphilis can affect the liver during the secondary stage as syphilitic hepatitis and during the tertiary stage as gummas. We describe 3 cases of syphilis in human immunodeficiency virus-positive homosexual men that presented as hepatic mass lesions clinically suspected of being malignant tumors. Histologically, 2 of the 3 cases showed a plump spindle cell proliferation, mixed inflammatory infiltrate with numerous neutrophils, and abscesses, whereas the third case showed granulomas and pericholangitis/cholangitis...
December 2014: American Journal of Surgical Pathology
Soma Kumasaka, Yukiko Arisaka, Azusa Tokue, Tetsuya Higuchi, Takahito Nakajima, Yoshito Tsushima
BACKGROUND: Hepatic angiomyolipoma is a rare benign mesenchymal tumor. We report an unusual case of a patient with multiple hepatic angiomyolipomas exhibiting high (18) F-fluorodeoxyglucose (FDG) uptake. CASE PRESENTATION: A 29-year-old man with a medical history of tuberous sclerosis was admitted to our hospital for fever, vomiting, and weight loss. Abdominal dynamic computed tomography revealed faint hypervascular hepatic tumors in segments 5 (67 mm) and 6 (10 mm), with rapid washout and clear borders; however, the tumors exhibited no definite fatty density...
2014: BMC Medical Imaging
Yoshihiro Yonekawa, Ivana K Kim, Evangelos S Gragoudas, Ching-Ni J Njauw, Hensin Tsao, Frederick A Jakobiec, Rebecca C Stacy
PURPOSE: We present the clinical, pathologic, and genetic findings of the first reported case of choroidal melanoma that developed a late recurrence and aggressive metastasis to the skull base without evidence of hepatic involvement. METHODS: Retrospective chart review and clinicopathologic correlation of ocular and brain tissue, including sequencing of BAP1 for mutations. RESULTS: A 55-year-old woman was diagnosed with choroidal melanoma and treated with proton radiotherapy...
September 2014: European Journal of Ophthalmology
Fabio Procopio, Luca Di Tommaso, Silvia Armenia, Vittorio Quagliuolo, Massimo Roncalli, Guido Torzilli
Nested stromal-epithelial tumours (NSETs) of the liver have been reported to be extremely unusual primary hepatic neoplasms. To date, few cases have been described in the literature. NSETs have been defined as non-hepatocytic and non-biliary tumours of the liver consisting of nests of epithelial and spindled cells, myofibroblastic stroma and variable intralesional calcification and ossification. Here, we report a case of a young female who underwent liver resection for a large hepatic lesion that proved to be a calcifying NSET on pathological examination...
March 27, 2014: World Journal of Hepatology
Jiong Lu, Jie Zhang, Xian-Ze Xiong, Fu-Yu Li, Hui Ye, Yao Cheng, Rong-Xing Zhou, Yi-Xin Lin, Nan-Sheng Cheng
PURPOSE: Primary hepatic sarcomatoid carcinoma (SC) is an extremely rare malignancy composed of both carcinomatous and spindle cell sarcomatous components. Our aim was to clarify the clinical features and prognosis of patients with this disease. METHODS: Between January 1996 and August 2012, 28 patients were histologically diagnosed as primary hepatic SC after surgical resection. Their demographic, clinicopathological, and survival data were retrospectively reviewed...
June 2014: Journal of Cancer Research and Clinical Oncology
Somayeh Bahrami, Saleh Esmaeilzadeh, Ahmad Oryan
Fasciola gigantica is a parasitic helminth that predominantly infects the liver and bile ducts of cattle and causes great losses of cattle production in the southwestern regions of Iran. The purpose of the present study was to find out the possible relationship between the extent of liver destruction and oxidative stress by estimating the level of MDA, and SOD and GPX enzymes in the liver of cattle infected with F. gigantica. Studies were carried out on 49 infected and 20 healthy livers. Based on the results, the SOD activity of the infected livers was substantially lower than those of the healthy ones...
June 16, 2014: Veterinary Parasitology
Donald P Taylor, Amanda Clark, Sarah Wheeler, Alan Wells
Nearly half of breast carcinoma metastases will become clinically evident five or more years after primary tumor ablation. This implies that metastatic cancer cells survived over an extended timeframe without emerging as detectable nodules. The liver is a common metastatic destination, whose parenchymal hepatocytes have been shown to impart a less invasive, dormant phenotype on metastatic cancer cells. We investigated whether hepatic nonparenchymal cells (NPCs) contributed to metastatic breast cancer cell outgrowth and a mesenchymal phenotypic shift indicative of emergence...
April 2014: Breast Cancer Research and Treatment
Cai He, Hong-fang Yin, Ping Liu, Ying Zhang, Jian-bo Zhang
OBJECTIVE: To investigate clinicopathological features of combined hepatocellular-cholangiocarcinoma (C-HCC-CC) with neuroendocrine carcinoma (NEC) differentiation and to review the literature. METHODS: The clinical data, histological manifestations and immunohistochemical staining results of two cases of C-HCC-CC were analyzed along with a review of the current literature. RESULTS: Both patients were male with an average age of 57.5 years...
December 2013: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Jessica A Clevenger, Romil Saxena, Muhammad T Idrees
Spindle cell neoplasms are rarely reported in liver allografts; most are benign and associated with Epstein-Barr virus infection. We present a case of a malignant spindle cell neoplasm arising in a liver allograft. The patient underwent orthotopic liver transplant for cirrhosis secondary to nonalcoholic steatohepatitis. After 2 years, he presented with vague abdominal complaints. Imaging studies revealed a 10-cm right hepatic lobe mass. The patient underwent right-sided hepatectomy. The tumor displayed areas of broad, relatively hypocellular fascicles, whorls, and perivascular clustering; spindle cells with mild to moderate nuclear pleomorphism; and relatively abundant eosinophilic cytoplasm...
February 2014: Archives of Pathology & Laboratory Medicine
Xiaogang Zhang, Lin Wang, Yina Jiang, Zhen Wan, Wenzhi Li, Chunhe Yao, Zhimin Geng, Yi Lv
Neoplasms of perivascular epithelioid cells (PEComas) are characterized by epithelioid to spindle cells with eosinophilic to clear cytoplasm, an intimate relationship with blood vessels, and coexpression of myoid and melanocytic immunohistochemical markers. While most reported hepatic PEComas, such as angiomyolipoma (AML), behave in a benign fashion, emerging PEComas cases without typical characteristics require further clarification. We report a case of primary hepatic perivascular epithelioid cell tumors-not otherwise specified (HPEComas-NOS) with untypical pathological and immunohistochemical features compared to those of the benign hepatic AML cases...
January 2014: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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