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https://www.readbyqxmd.com/read/28647708/relapsing-cerebral-amyloid-angiopathy-related-inflammation-the-wax-and-the-wane
#1
Sharfaraz Salam, Mayooreshan Anandarajah, Sarah Al-Bachari, Piyali Pal, Jonathan Sussman, Hisham Hamdalla
Cerebral amyloid angiopathy-related inflammation (CAA-I) is a rare variant of cerebral amyloid angiopathy (CAA). Its precise pathophysiology remains uncertain and we currently have limited evidence on which immunosuppressive agents are the most effective in its treatment. The disease course of CAA-I disorders can vary from an isolated clinical event to recurrent episodes. We present a case of biopsy-confirmed CAA-I that gives insight into its potential relapsing nature and the challenges of its long-term management...
June 24, 2017: Practical Neurology
https://www.readbyqxmd.com/read/28639881/suspected-lateral-periodontal-cyst-presenting-concurrently-with-canine-acanthomatous-ameloblastoma-in-a-2-year-old-standard-poodle
#2
Jennifer Tjepkema, Cynthia Bell
Lateral periodontal cysts (LPCs) are odontogenic epithelial cysts composed of nonkeratinized epithelial cells that are in the category of developmental cysts, rather than inflammatory cysts. Lateral periodontal cysts are rare in both people and domestic animals; they are associated with vital teeth and located lateral to a tooth root. Lateral periodontal cysts are typically asymptomatic lesions that are characterized radiographically as a unilocular lucency with well-defined corticated borders. Canine acanthomatous ameloblastoma (CAA) is the most common odontogenic neoplasm in dogs and rarely presents as a cystic lesion...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28639826/imaging-appearance-of-advanced-chronic-adhesive-arachnoiditis-a-retrospective-review
#3
Tara L Anderson, Jonathan M Morris, John T Wald, Amy L Kotsenas
OBJECTIVE: Chronic adhesive arachnoiditis (CAA) is rare and has potentially devastating clinical consequences. The objective of this article is to review the clinical features of CAA and describe its appearance on imaging, to increase radiologists' awareness of this challenging diagnosis. MATERIALS AND METHODS: Twenty-nine cases of advanced CAA seen at our institution over 18 years (1995-2013) were retrospectively reviewed. Chart review was performed, with attention given to data on clinical presentation, suspected cause, and interventions performed...
June 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28613396/evaluation-of-acetylcholinesterase-and-carbonic-anhydrase-inhibition-profiles-of-1-2-3-4-6-pentasubstituted-4-hydroxy-cyclohexanes
#4
Umit M Kocyigit, Parham Taslimi, Hayreddin Gezegen, İlhami Gulçin, Mustafa Ceylan
Carbonic anhydrase (CA; EC 4.2.1.1) is used for remedial purposes for several years, as there is significant focus on expanding more new activators (CAAs) and high affinity inhibitors. Alzheimer's disease and other similar ailments such as dementia and vascular dementia with Lewy bodies reduce cholinergic activity in the important areas involved in cognition and memory. Prevalent drugs for the symptomatic therapy of dementia are significant in increasing the associated cholinergic deficiency by inhibiting acetylcholinesterase (AChE)...
June 14, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28603725/multi-vessel-giant-coronary-artery-aneurysm-in-an-elderly-female
#5
Rami N Khouzam, Jonathan D Gardner, Ritin Bomb, Anthony A Holden
Coronary artery aneurysm (CAA) is a rare anomaly. The right coronary artery is the most commonly affected, followed by the left circumflex (LCX), or the left anterior descending artery (LAD). Three-vessel disease or left main (LM) involvement is extremely rare. A giant coronary artery aneurysm (GCAA) has an extremely low incidence and refers to an aneurysm that is 20 mm or greater in size. Most CAAs occur as a consequence of atherosclerosis. Most patients with CAA are males, have three-vessel disease, and a history of myocardial infarction (MI)...
May 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28601994/radiologic-features-of-dropped-head-syndrome-in-the-overall-sagittal-alignment-of-the-spine
#6
Kazuki Hashimoto, Hiroshi Miyamoto, Terumasa Ikeda, Masao Akagi
PURPOSE: Dropped head syndrome (DHS) is a rare clinical entity which is defined as a chin-on-chest deformity in the standing or sitting position, resulting from sagittal imbalance of the cervical region. The purpose of the present study was to clarify the radiologic features of DHS in the overall sagittal alignment of the spine. We also investigated the changes in sagittal alignment after correction surgery for DHS. METHODS: Twenty DHS patients [1 male and 19 female, with an average age of 78...
June 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28583195/effects-of-phosphodiesterase-3a-modulation-on-murine-cerebral-microhemorrhages
#7
Rachita K Sumbria, Vitaly Vasilevko, Mher Mahoney Grigoryan, Annlia Paganini-Hill, Ronald Kim, David H Cribbs, Mark J Fisher
BACKGROUND: Cerebral microbleeds (CMB) are MRI-demonstrable cerebral microhemorrhages (CMH) which commonly coexist with ischemic stroke. This creates a challenging therapeutic milieu, and a strategy that simultaneously protects the vessel wall and provides anti-thrombotic activity is an attractive potential approach. Phosphodiesterase 3A (PDE3A) inhibition is known to provide cerebral vessel wall protection combined with anti-thrombotic effects. As an initial step in the development of a therapy that simultaneously treats CMB and ischemic stroke, we hypothesized that inhibition of the PDE3A pathway is protective against CMH development...
June 5, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28579092/coronary-artery-aneurysm-formation-following-implantation-of-a-bioresorbable-vascular-scaffold-for-in-stent-restenosis
#8
Marcos García-Guimaraes, Javier Cuesta, Teresa Alvarado, Fernando Rivero, Teresa Bastante, Amparo Benedicto, Fernando Alfonso
Coronary artery aneurysm (CAA) formation is a rare complication of coronary intervention that may develop after implantation of bare-metal or drug-eluting stents. The etiology of this entity appears to be multifactorial and its prognosis is poorly understood, but it has been associated with an increased risk of stent thrombosis. To date few cases of CAAs related to bioresorbable vascular scaffold (BVS) implantation have been reported, and the development of CAA after BVS implantation for the treatment of in-stent restenosis (ISR) has not been previously described...
May 31, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28573221/efficacy-and-safety-of-ban-huang-oral-liquid-for-treating-bovine-respiratory-diseases
#9
Bing Li, Xu-Zheng Zhou, Jian-Rong Niu, Xiao-Juan Wei, Jian-Yong Li, Ya-Jun Yang, Xi-Wang Liu, Fu-Sheng Cheng, Ji-Yu Zhang
BACKGROUND: Ban Huang oral liquid was developed as a veterinary compound preparation by the Lanzhou Institute of Husbandry and Pharmaceutical Sciences of the Chinese Academy of Agricultural Sciences (CAAS). The purpose of this study was to determine whether the oral liquid preparation of traditional Chinese medicine, Ban Huang, is safe and effective for treating respiratory diseases in cattle. MATERIALS AND METHODS: Acute oral toxicity experiments were conducted in Wistar rats and Kunming mice via oral administration...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28571327/the-covalent-interaction-between-dihydrogen-and-gold-a-rotational-spectroscopic-study-of-h2-aucl
#10
Daniel A Obenchain, Derek S Frank, G S Grubbs, Herbert M Pickett, Stewart E Novick
The pure rotational transitions of H2-AuCl have been measured using a pulsed-jet cavity Fourier transform microwave spectrometer equipped with a laser ablation source. The structure was found to be T-shaped, with the H-H bond interacting with the gold atom. Both (35)Cl and (37)Cl isotopologues have been measured for both ortho and para states of H2. Rotational constants, quartic centrifugal distortion constants, and nuclear quadrupole coupling constants for gold and chlorine have been determined. The use of the nuclear spin-nuclear spin interaction terms Daa, Dbb, and Dcc for H2 were required to fit the ortho state of hydrogen, as well as a nuclear-spin rotation constant Caa...
May 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28570698/high-prevalence-of-cognitive-impairment-after-intracerebral-hemorrhage
#11
Mélanie Planton, Laure Saint-Aubert, Nicolas Raposo, Laura Branchu, Aicha Lyoubi, Fabrice Bonneville, Jean-François Albucher, Jean-Marc Olivot, Patrice Péran, Jérémie Pariente
BACKGROUND: Cognitive impairment seems to be frequent in intracerebral hemorrhage (ICH) survivors, but remains widely understudied. In this study, we investigated the frequency and patterns of vascular cognitive disorders (VCDs) in patients with cerebral amyloid angiopathy (CAA)-related and deep ICH compared to patients with mild cognitive impairment due to Alzheimer's disease (MCI-AD) and healthy controls. METHODS: We prospectively recruited 20 patients with CAA-related lobar ICH, 20 with deep ICH, 20 with MCI-AD and 17 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28566299/predicting-coronary-artery-aneurysms-in-kawasaki-disease-at-a-north-american-center-an-assessment-of-baseline-z-scores
#12
Mary Beth F Son, Kimberlee Gauvreau, Susan Kim, Alexander Tang, Fatma Dedeoglu, David R Fulton, Mindy S Lo, Annette L Baker, Robert P Sundel, Jane W Newburger
BACKGROUND: Accurate risk prediction of coronary artery aneurysms (CAAs) in North American children with Kawasaki disease remains a clinical challenge. We sought to determine the predictive utility of baseline coronary dimensions adjusted for body surface area (z scores) for future CAAs in Kawasaki disease and explored the extent to which addition of established Japanese risk scores to baseline coronary artery z scores improved discrimination for CAA development. METHODS AND RESULTS: We explored the relationships of CAA with baseline z scores; with Kobayashi, Sano, Egami, and Harada risk scores; and with the combination of baseline z scores and risk scores...
May 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28560150/amyloid-positron-emission-tomography-in-sporadic-cerebral-amyloid-angiopathy-a-systematic-critical-update
#13
REVIEW
Karim Farid, Andreas Charidimou, Jean-Claude Baron
Sporadic cerebral amyloid angiopathy (CAA) is a very common small vessel disease of the brain, showing preferential and progressive amyloid-βdeposition in the wall of small arterioles and capillaries of the leptomeninges and cerebral cortex. CAA now encompasses not only a specific cerebrovascular pathological trait, but also different clinical syndromes - including spontaneous lobar intracerebral haemorrhage (ICH), dementia and 'amyloid spells' - an expanding spectrum of brain parenchymal MRI lesions and a set of diagnostic criteria - the Boston criteria, which have resulted in increasingly detecting CAA during life...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28557134/tgf%C3%AE-pathway-deregulation-and-abnormal-phospho-smad2-3-staining-in-hereditary-cerebral-hemorrhage-with-amyloidosis-dutch-type
#14
Laure Grand Moursel, Leon P Munting, Linda M van der Graaf, Sjoerd G van Duinen, Marie-Jose T H Goumans, Uwe Ueberham, Remco Natté, Mark A van Buchem, Willeke M C van Roon-Mom, Louise van der Weerd
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) pathology, caused by the E22Q mutation in the amyloid β (Aβ) peptide. Transforming Growth Factor β1 (TGFβ1) is a key player in vascular fibrosis and in the formation of angiopathic vessels in transgenic mice. Therefore we investigated whether the TGFβ pathway is involved in HCHWA-D pathogenesis in human postmortem brain tissue from frontal and occipital lobes. Components of the TGFβ pathway were analyzed with quantitative RT-PCR...
May 29, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28552449/safety-and-efficacy-of-warfarin-therapy-in-kawasaki-disease
#15
Annette L Baker, Christina Vanderpluym, Kimberly A Gauvreau, David R Fulton, Sarah D de Ferranti, Kevin G Friedman, Jenna M Murray, Loren D Brown, Christopher S Almond, Margaret Evans-Langhorst, Jane W Newburger
OBJECTIVE: To describe the safety and efficacy of warfarin for patients with Kawasaki disease and giant coronary artery aneurysms (CAAs, ≥8 mm). Giant aneurysms are managed with combined anticoagulation and antiplatelet therapies, heightening risk of bleeding complications. STUDY DESIGN: We reviewed the time in therapeutic range; percentage of international normalization ratios (INRs) in range (%); bleeding events, clotting events; INRs ≥6; INRs ≥5 and <6; and INRs <1...
May 25, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28538210/correlation-of-hamp-gene-polymorphisms-and-expression-with-the-susceptibility-and-length-of-hospital-stays-in-taiwanese-children-with-kawasaki-disease
#16
Ying-Hsien Huang, Kuender D Yang, Yu-Wen Hsu, Hsing-Fang Lu, Henry Sung-Ching Wong, Hong-Ren Yu, Hsing-Chun Kuo, Fu-Chen Huang, Mao-Hung Lo, Kai-Sheng Hsieh, Su-Fen Chen, Wei-Chiao Chang, Ho-Chang Kuo
Kawasaki disease (KD) is a form of systemic vasculitis. Regarding its pathogenesis, HAMP gene encoding hepcidin, which is significant for iron metabolism, has a vital function. In this study, we recruited a total of 381 KD patients for genotyping. Data from 997 subjects (500 subjects from cohort 1; 497 subjects from cohort 2) were used for analysis. Using TaqMan allelic discrimination, we determined five tag SNPs (rs916145, rs10421768, rs3817623, rs7251432, and rs2293689). Treatment outcome data related to such clinical phenotypes as coronary artery lesions (CAL), coronary artery aneurysms (CAA), and intravenous immunoglobulin (IVIG) effects were also collected...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28529940/coronary-artery-aneurysms-a-review-of-the-epidemiology-pathophysiology-diagnosis-and-treatment
#17
REVIEW
Sara Abou Sherif, Ozge Ozden Tok, Özgür Taşköylü, Omer Goktekin, Ismail Dogu Kilic
Coronary artery aneurysms (CAAs) are uncommon and describe a localized dilatation of a coronary artery segment more than 1.5-fold compared with adjacent normal segments. The incidence of CAAs varies from 0.3 to 5.3%. Ever since the dawn of the interventional era, CAAs have been increasingly diagnosed on coronary angiography. Causative factors include atherosclerosis, Takayasu arteritis, congenital disorders, Kawasaki disease (KD), and percutaneous coronary intervention. The natural history of CAAs remains unclear; however, several recent studies have postulated the underlying molecular mechanisms of CAAs, and genome-wide association studies have revealed several genetic predispositions to CAA...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28523359/arginine-cga-codons-as-a-source-of-nonsense-mutations-a-possible-role-in-multivariant-gene-expression-control-of-mrna-quality-and-aging
#18
Georgy A Romanov, Victor S Sukhoverov
Methylation of cytosine residues in DNA of higher eukaryotes, including humans, creates "hot spots" of C→T transitions in the genome. The predominantly methylated sequence in mammalian DNAs is CG (CpG). Among CG-containing codons, CGA codons for arginine are unique due to their ability to create stop codons TGA (UGA in mRNA) upon epigenetic-mediated mutation. As such nonsense mutations can have a strong adverse effect on the cell and organism, we have performed a study, on the example of human genes, aimed to characterise the anticipated effects of epigenetic-mediated nonsense mutations CGA→TGA in somatic cells...
May 18, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28521976/facile-synthesis-of-cellulose-derivatives-based-on-cellulose-acetoacetate
#19
Hongchen Liu, Liduo Rong, Bijia Wang, Zhiping Mao, Ruyi Xie, Hong Xu, Linping Zhang, Yi Zhong, Xiaofeng Sui
In the present work, cellulose acetoacetates (CAA) was used as a precursor for preparing diversely functionalized cellulose derivatives. Four amino-bearing compounds, namely hexylamine (HA), l-glutamic acid (Glu), cysteine (Cys), and tyramine (TA) were reacted with acetoacetyl groups providing alkyl-, carboxyl-, thiol-, or phenolic functionalized cellulose. The reaction was conducted under mild conditions without catalysts and UV light. The products were characterized with FT-IR, NMR and solubility measurement...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28512721/mid-term-risk-for-subclinical-atherosclerosis-and-chronic-myocarditis-in-children-with-kawasaki-disease-and-transient-coronary-abnormalities
#20
Mansingh Parihar, Surjit Singh, Pandiarajan Vignesh, Anju Gupta, Manojkumar Rohit
There is evidence for premature atherosclerosis and systemic arterial stiffening during follow-up of children with Kawasaki disease (KD) and coronary artery abnormalities (CAA). Moreover, patients with KD may also have subclinical myocardial involvement and inhomogeneous ventricular repolarization. The inhomogeneous ventricular repolarization manifests as increased QT dispersion on electrocardiography. There is a paucity of studies in endothelial dysfunction and QT dispersion in children with KD and transient CAA...
May 17, 2017: Pediatric Cardiology
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