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https://www.readbyqxmd.com/read/29220486/transcriptome-signatures-of-selection-drift-introgression-and-gene-duplication-in-the-evolution-of-an-extremophile-endemic-plant
#1
Angela K Hawkins, Elyssa R Garza, Valerie A Dietz, Oscar J Hernandez, W Daryl Hawkins, A Millie Burrell, Alan E Pepper
Plants on serpentine soils provide extreme examples of adaptation to environment, and thus offer excellent models for the study of evolution at the molecular and genomic level. Serpentine outcrops are derived from ultramafic rock and have extremely low levels of essential plant nutrients (e.g. N, P, K, Ca), as well as toxic levels of heavy metals (e.g. Ni, Cr, Co) and low moisture availability. These outcrops provide habitat to a number of endemic plant species, including the annual mustard Caulanthus amplexicaulis var...
December 6, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29218776/is-the-consumption-of-snail-meat-actually-healthy-an-analysis-of-the-osteotropic-influence-of-snail-meat-as-a-sole-source-of-protein-in-growing-rats
#2
R P Radzki, M Bieńko, P Polak, K Szkucik, M Ziomek, M Ostapiuk, J Bieniaś
The study was aimed at determining the osteotropic effects of diets containing snail meat as a sole protein source. In our experiment, we tested three different diets incorporating snail meat originating from Helix pomatia (HP), Cornu.aspesa maxima (CAM) and Cornu.aspersum aspersum (CAA) and compared these to a control diet (CON) in which casein was the source of protein. In all diets, the protein content amounted to 10%, as calculated on a dry weight basis. In the study, forty male Wistar rats with an initial body mass of 50 ± 2 g were randomly placed within the control and three experimental groups...
December 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29207079/molecular-basis-of-coronary-artery-dilation-and-aneurysms-in-patients-with-kawasaki-disease-based-on-differential-protein-expression
#3
Wanting Liu, Chaowu Liu, Li Zhang, Xiaofei Xie, Xiaoqiong Gu, Chuanlan Sang, Mingguo Xu, Weijun Xu, Hongling Jia
Kawasaki disease (KD) is an acquired cardiac disease with a high incidence that affects children. KD has various complications, including coronary artery dilation (CAD) and coronary artery aneurysms (CAA). The identification of differentially expressed proteins and the underlying mechanisms may be the key to understanding differences between these KD complications. In the present study, isobaric tags for relative and absolute quantitation were used to identify variations in serum proteins between KD patients with CAD and CAA...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29204961/patterns-of-convexal-subarachnoid-haemorrhage-clinical-radiological-and-outcome-differences-between-cerebral-amyloid-angiopathy-and-other-causes
#4
Lionel Calviere, Nicolas Raposo, Victor Cuvinciuc, Christophe Cognard, Fabrice Bonneville, Alain Viguier
BACKGROUND: Cerebral amyloid angiopathy (CAA) is a common aetiology of convexal subarachnoid haemorrhage (cSAH) but little is known about its specific characteristics in comparison with cSAH from other causes. In this study we compared patients with CAA vs. non-CAA-related cSAH. METHODS: Retrospective review of baseline and follow-up data of consecutive patients admitted with a symptomatic acute cSAH. RESULTS: Sixty-two patients were included (mean age 66...
December 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29201555/background-and-distribution-of-lobar-microbleeds-in-cognitive-dysfunction
#5
Hirofumi Matsuyama, Yuichiro Ii, Masayuki Maeda, Maki Umino, Yukito Ueda, Ken-Ichi Tabei, Hirotaka Kida, Masayuki Satoh, Akihiro Shindo, Akira Taniguchi, Ryosuke Takahashi, Hidekazu Tomimoto
Objectives: Cerebral microbleeds (CMBs) are often observed in memory clinic patients. It has been generally accepted that deep CMBs (D-CMBs) result from hypertensive vasculopathy (HV), whereas strictly lobar CMBs (SL-CMBs) result from cerebral amyloid angiopathy (CAA) which frequently coexists with Alzheimer's disease (AD). Mixed CMBs (M-CMBs) have been partially attributed to HV and also partially attributed to CAA. The aim of this study was to elucidate the differences between SL-CMBs and M-CMBs in terms of clinical features and regional distribution...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29200923/an-annotated-and-illustrated-checklist-of-microgastrinae-wasps-hymenoptera-braconidae-from-the-canadian-arctic-archipelago-and-greenland
#6
Jose Fernández-Triana, Joel Buffam, Melanie Beaudin, Hannah Davis, Ana Fernández-Galliano, Emily Griffin, Shang-Yao Lin, Megan K McAulay, Robin Richter, Freddy Rodriguez, Gergely Várkonyi
The Microgastrinae (Hymenoptera: Braconidae) from ten islands of the Canadian Arctic Archipelago (CAA) and Greenland were studied based on 2,183 specimens deposited in collections. We report a total of 33 species in six genera, more than doubling the totals previously known. Most of the species (75.7%) have a distribution restricted to the Nearctic, with nine of those (27.3%) confirmed to be High Arctic endemics and another 10 species considered very likely to be High Arctic endemics as well - accounting for all of those, more than half of all species found are endemic to the region...
2017: ZooKeys
https://www.readbyqxmd.com/read/29195510/cerebrovascular-pathology-in-down-syndrome-and-alzheimer-disease
#7
Elizabeth Head, Michael J Phelan, Eric Doran, Ronald C Kim, Wayne W Poon, Frederick A Schmitt, Ira T Lott
People with Down syndrome (DS) are at high risk for developing Alzheimer disease (AD) with age. Typically, by age 40 years, most people with DS have sufficient neuropathology for an AD diagnosis. Interestingly, atherosclerosis and hypertension are atypical in DS with age, suggesting the lack of these vascular risk factors may be associated with reduced cerebrovascular pathology. However, because the extra copy of APP leads to increased beta-amyloid peptide (Aβ) accumulation in DS, we hypothesized that there would be more extensive and widespread cerebral amyloid angiopathy (CAA) with age in DS relative to sporadic AD...
December 1, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29189022/using-counterattitudinal-advocacy-to-change-drinking-a-pilot-study
#8
Angelo M DiBello, Kate B Carey, Vanessa Cushing
The persistence of risky drinking among young adults in college calls for continued efforts to prevent alcohol-related harms. This study tested a novel prevention strategy targeting a specific mechanism of change: creating attitude-behavior dissonance. Informed by an extensive literature showing strong and consistent associations between alcohol attitudes and drinking behavior, we adapted a brief counterattitudinal advocacy (CAA) manipulation to the alcohol prevention context. We conducted a small randomized controlled trial with 49 heavy-drinking students who reported drinking 4/5 drinks in 1 sitting (female/male, respectively) and endorsed ≥2 alcohol-related consequences in the previous month...
November 30, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29181042/associations-between-coronary-artery-disease-aneurysm-and-ectasia
#9
Cengiz Ovalı, Baktash Morrad
Aim: Investigation the frequency and contribution of coronary artery aneurysm/ectasia in addition to their correlation with coronary artery disease (CAD). Material and methods: We retrospectively evaluated the coronary angiography records of 6500 adult consecutive patients, and 418 of them were met inclusion criteria and used in the present study. The CAD was defined as the presence of angiographic coronary stenosis of > 50% of the luminal diameter in no less than one of the epicardial coronary arteries...
September 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/29173297/the-clinical-utility-and-safety-of-a-new-strategy-for-the-treatment-of-refractory-kawasaki-disease
#10
Takasuke Ebato, Shohei Ogata, Yoshihito Ogihara, Mayu Fujimoto, Atsushi Kitagawa, Manabu Takanashi, Masahiro Ishii
OBJECTIVE: To assess the clinical utility and safety of a strategy for refractory Kawasaki disease, defined by Egami score ≥3. STUDY DESIGN: First-line treatment was with intravenous methylprednisolone (30 mg/kg, 2 hours, 1 dose) plus intravenous immunoglobulin (2 g/kg, 24 hours) treatment. Patients resistant to first-line treatment received additional intravenous immunoglobulin as a second-line treatment. Patients resistant to second-line treatment who had received Bacillus Calmette-Guérin vaccination 6 months earlier were treated with infliximab; otherwise, plasma exchange was performed...
December 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29172158/facing-the-rain-after-the-phase-out-performance-evaluation-of-alternative-fluorinated-and-non-fluorinated-durable-water-repellents-for-outdoor-fabrics
#11
S Schellenberger, P Gillgard, A Stare, A Hanning, O Levenstam, S Roos, I T Cousins
Fluorinated durable water repellent (DWR) agents are used to obtain water and stain repellent textiles. Due to the on-going phase-out of DWRs based on side-chain fluorinated polymers (SFP) with "long" perfluoroalkyl chains, the textile industry lacks suitable alternatives with comparable material characteristics. The constant development and optimization of SFPs for textile applications initiated more than half a century ago has resulted in a robust and very efficient DWR-technology and textiles with exceptional hydro- and oleo-phobic properties...
November 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29168672/acute-diffusion-weighted-imaging-lesions-in-cerebral-amyloid-angiopathy-related-convexal-subarachnoid-hemorrhage
#12
Markus Beitzke, Christian Enzinger, Alexander Pichler, Gerit Wünsch, Franz Fazekas
Small acute diffusion-weighted imaging (DWI) lesions can accompany intracerebral hemorrhage due to cerebral amyloid angiopathy (CAA). We therefore examined the occurrence of such lesions in the context of CAA-related convexal subarachnoid hemorrhage (cSAH) both in a cross-sectional and longitudinal manner. DWI lesions were noted in 14/29 (48%) patients at their index cSAH and 12/21 patients (57%) showed acute small DWI lesions at follow-up MRI. Forty-four of 71 (62%) DWI lesions were spatially related to areas of cortical superficial siderosis...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29167486/distinctive-clinical-effects-of-haemorrhagic-markers-in-cerebral-amyloid-angiopathy
#13
Young Kyoung Jang, Hee Jin Kim, Jin San Lee, Yeo Jin Kim, Ko Woon Kim, Yeshin Kim, Hyemin Jang, Juyoun Lee, Jong Min Lee, Seung-Joo Kim, Kyung-Ho Yu, Andreas Charidimou, David J Werring, Sung Tae Kim, Duk L Na, Sang Won Seo
Restricted lobar cerebral microbleeds (CMBs) and cortical superficial siderosis (CSS) are the characteristic markers of cerebral amyloid angiopathy (CAA). However, their effects on clinical features has not been evaluated well. The purpose of this study is to investigate the clinical implication of these markers in clinical-radiologically diagnosed CAA. A total of 372 patients with possible or probable CAA who met the modified Boston criteria were recruited in a memory clinic setting. Cortical thickness was measured using surface based methods...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29164770/clinical-outcomes-of-patients-with-coronary-artery-aneurysm-after-the-first-generation-drug-eluting-stent-implantation
#14
Hyung Joon Joo, Cheol Woong Yu, RakKyeong Choi, Jinsik Park, Hyun Jong Lee, Je Sang Kim, Young Jin Choi, Jae Hyoung Park, Soon Jun Hong, Do Sun Lim
OBJECTIVES: We sought to investigate the long-term clinical outcomes of patients with coronary artery aneurysm (CAA) after drug-eluting stent (DES) implantation, compared with patients without CAA. BACKGROUND: CAA developed after DES implantation is a rare but associated with poor clinical outcome. METHODS: We retrospectively compared 78 patients with CAA after DES implantation with 269 patients without CAA who underwent DES implantation for complex lesions (controls)...
November 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29159445/probiotic-properties-and-cellular-antioxidant-activity-of-lactobacillus-plantarum-ma2-isolated-from-tibetan-kefir-grains
#15
Wei Tang, Chao Li, Zengguo He, Fen Pan, Shuo Pan, Yanping Wang
Lactobacillus plantarum MA2 was isolated from traditional Chinese Tibetan kefir grains. Its antioxidant properties had been demonstrated in vitro and in vivo previously. In the present study, the probiotic characteristics of this strain were further evaluated by investigating its acid and bile salt tolerances, cell surface hydrophobicity, and autoaggregation, respectively. In addition, the cellular antioxidant activity (CAA) assay was applied to test the antioxidant capacity of the isolate in different growth phases...
November 20, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29155805/epidemiology-and-outcomes-of-community-acquired-and-hospital-acquired-acute-kidney-injury-in-children-and-adolescents
#16
Chien-Ning Hsu, Hsiao-Ling Chen, You-Lin Tain
BACKGROUND: Hospital-acquired acute kidney injury (HA-AKI) is associated with an increased risk of childhood mortality; however, only a few studies have addressed community-acquired AKI (CA-AKI). METHODS: AKI Network classification was used to assess community- and hospital-acquired AKI, 2010-2014. Patients with CA-AKI who were admitted to an inpatient setting were categorized as CAA-AKI. CANA-AKI was for CA-AKI not admitted to inpatient care. Epidemiology, factors associated with AKI, in-hospital outcomes were assessed for variation...
November 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29154751/the-etiology-of-spontaneous-intracerebralhemorrhage-insights-from-a-neuropathological-series
#17
Luis Ruano, Mariana Branco, Raquel Samões, Ricardo Taipa, Manuel Melo Pires
The etiology of intracerebral hemorrhage (ICH) is frequently undetermined. We aimed to assess the impact of the neuropathological study on the etiologic diagnosis of ICH. Patients with ICH admitted to a tertiary hospital in the last 14 years were identified, and histological samples of surgically-drained ICH were retrieved. Blinded from neuropathological results, a clinical etiology was hypothesized. Pathological samples were reviewed, and immunohistochemistry study for β-amyloid was performed in all the cases where structural abnormalities were not identified...
November 20, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/29135355/changes-in-ocular-hemodynamics-after-carotid-artery-angioplasty-and-stenting-caas-in-patients-with-different-severity-of-ocular-ischemic-syndrome
#18
Feiyan Ma, Jing Su, Qingli Shang, Jingxue Ma, Tongdi Zhang, Xin Wang, Honglei Ma, Jianghua Yu
PURPOSE: To evaluate the effects of carotid artery angioplasty and stenting (CAAS) on patients who were diagnosed with ocular ischemic syndrome (OIS). METHODS: Sixty-four eyes of 64 OIS patients with ipsilateral internal carotid artery stenosis ≥70% were included in the study. The study eyes were divided into two groups according to the presence of iris neovascularization: NVI-absent group and NVI-present group, with 32 eyes, respectively. All patients received ocular treatment modality according to the presence of non-perfusion area (pan-retinal photocoagulation) and intraocular pressure (medical treatment included timolol maleate eye drops combined with brinzolamide eye drop; trabeculectomy and cyclophotocoagulation)...
November 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29129847/effects-of-ketoconazole-on-cyclophosphamide-metabolism-evaluation-of-cyp3a4-inhibition-effect-using-the-in-vitro-and-in-vivo-models
#19
Le Yang, Chenyang Yan, Feng Zhang, Bo Jiang, Shouhong Gao, Youtian Liang, Lifeng Huang, Wansheng Chen
Cyclophosphamide (CP) is widely used in anticancer therapy regimens and 2-dechloroethylcyclophosphamide (DECP) is its side-chain dechloroethylated metabolite. N-dechloroethylation of CP mediated by the enzyme CYP3A4 yields nephrotoxic and neurotoxic chloroacetaldehyde (CAA) in equimolar amount to DECP. This study aimed to evaluate the inhibitory effect of ketoconazole (KTZ) on CP metabolism through in vitro and in vivo drug-drug interaction (DDI) research. Long-term treatment of KTZ induces hepatic injury; thus single doses of KTZ at low, middle, and high levels (10, 20, and 40 mg/kg) were investigated for pharmacokinetic DDI with CP...
November 13, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29120920/the-growing-clinical-spectrum-of-cerebral-amyloid-angiopathy
#20
Marieke J H Wermer, Steven M Greenberg
PURPOSE OF REVIEW: Cerebral amyloid angiopathy (CAA) is diagnosed primarily as a cause of lobar intracerebral hemorrhages (ICH) in elderly patients. With improving MRI techniques, however, the role of CAA in causing other symptoms has become clear. Recognizing the full clinical spectrum of CAA is important for diagnosis and treatment. In this review we summarize recent insights in clinical CAA features, MRI biomarkers, and management. RECENT FINDINGS: The rate of ICH recurrence in CAA is among the highest of all stroke subtypes...
November 7, 2017: Current Opinion in Neurology
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