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https://www.readbyqxmd.com/read/28728954/ultrasound-histopathological-and-genetic-features-of-uveal-melanoma-in-a-mexican-mestizo-population
#1
S Delgado, A Rodriguez Reyes, L Mora Rios, A Dueñas-González, L Taja-Chayeb, E Moragrega Adame
OBJECTIVE: To describe the ultrasound, histopathological and genetic characteristics of uveal melanoma in a Mexican-Mestizo population. MATERIAL AND METHODS: A total of 39 enucleated eyes with a histopathological diagnosis of uveal melanoma were assessed by describing the clinical findings, and ultrasound, histopathological and genetic features. RESULTS: A high correlation was observed between tumour height measurement using ultrasound and histopathology...
July 17, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28724587/florbetapir-imaging-in-cerebral-amyloid-angiopathy-related-hemorrhages
#2
Nicolas Raposo, Mélanie Planton, Patrice Péran, Pierre Payoux, Fabrice Bonneville, Aicha Lyoubi, Jean François Albucher, Blandine Acket, Anne Sophie Salabert, Jean Marc Olivot, Anne Hitzel, François Chollet, Jérémie Pariente
OBJECTIVE: To assess whether (18)F-florbetapir, a PET amyloid tracer, could bind vascular amyloid in cerebral amyloid angiopathy (CAA) by comparing cortical florbetapir retention during the acute phase between patients with CAA-related lobar intracerebral hemorrhage (ICH) and patients with hypertension-related deep ICH. METHODS: Patients with acute CAA-related lobar ICH were prospectively enrolled and compared with patients with deep ICH. (18)F-florbetapir PET, brain MRI, and APOE genotype were obtained for all participants...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28717091/thrombolysis-related-multiple-lobar-hemorrhaging-in-cerebral-amyloid-angiopathy-with-extensive-strictly-lobar-cerebral-microbleeding
#3
Makoto Eriguchi, Yusuke Yakushiji, Jun Tanaka, Masashi Nishihara, Hideo Hara
A hemi-paralyzed 86-year-old man was diagnosed with ischemic stroke and underwent thrombolysis. Pre-thrombolysis brain magnetic resonance imaging revealed extensive strictly lobar cerebral microbleeding (CMB). Post-thrombolytic computed tomography revealed asymptomatic multiple intracerebral hemorrhaging (ICH). His age, CMB topography, and decreased cerebral spinal fluid amyloid-β 40 and 42 levels were compatible with a diagnosis of cerebral amyloid angiopathy (CAA). There is no consensus on the safety of thrombolysis for acute stroke patients with CAA...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28715174/tunable-upper-critical-solution-temperatures-for-acrylamide-copolymers-with-bile-acid-pendants
#4
Yongguang Jia, Qixuan Yu, Zhiyuan Ma, Meng Zhang, Julian X X Zhu
Acrylamide derivatives of bile acids are chosen as a hydrophobic comonomer to copolymerize with acrylamide via reversible addition and fragmentation chain transfer (RAFT) polymerization to afford a series of copolymers of P(AAm-co-CAA). These copolymers exhibit a sharp and reversible insoluble-soluble transition in water upon heating to a mixing temperature (Tmix) related to the upper critical solution temperature (UCST). Tmix of these copolymers can be conveniently tuned to a practical temperature range, around 37 °C for biomedical applications...
July 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28701379/loss-of-clusterin-shifts-amyloid-deposition-to-the-cerebrovasculature-via-disruption-of-perivascular-drainage-pathways
#5
Aleksandra M Wojtas, Silvia S Kang, Benjamin M Olley, Maureen Gatherer, Mitsuru Shinohara, Patricia A Lozano, Chia-Chen Liu, Aishe Kurti, Kelsey E Baker, Dennis W Dickson, Mei Yue, Leonard Petrucelli, Guojun Bu, Roxana O Carare, John D Fryer
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) peptide deposition in brain parenchyma as plaques and in cerebral blood vessels as cerebral amyloid angiopathy (CAA). CAA deposition leads to several clinical complications, including intracerebral hemorrhage. The underlying molecular mechanisms that regulate plaque and CAA deposition in the vast majority of sporadic AD patients remain unclear. The clusterin (CLU) gene is genetically associated with AD and CLU has been shown to alter aggregation, toxicity, and blood-brain barrier transport of Aβ, suggesting it might play a key role in regulating the balance between Aβ deposition and clearance in both brain and blood vessels...
July 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28700676/imaging-features-of-intracerebral-hemorrhage-with-cerebral-amyloid-angiopathy-systematic-review-and-meta-analysis
#6
Neshika Samarasekera, Mark Alexander Rodrigues, Pheng Shiew Toh, Rustam Al-Shahi Salman
BACKGROUND: We sought to summarize Computed Tomography (CT)/Magnetic Resonance Imaging (MRI) features of intracerebral hemorrhage (ICH) associated with cerebral amyloid angiopathy (CAA) in published observational radio-pathological studies. METHODS: In November 2016, two authors searched OVID Medline (1946-), Embase (1974-) and relevant bibliographies for studies of imaging features of lobar or cerebellar ICH with pathologically proven CAA ("CAA-associated ICH")...
2017: PloS One
https://www.readbyqxmd.com/read/28697558/comparative-analysis-of-cortical-microinfarcts-and-microbleeds-using-3-0-tesla-postmortem-magnetic-resonance-images-and-histopathology
#7
Atsushi Niwa, Yuichiro Ii, Akihiro Shindo, Ko Matsuo, Hidehiro Ishikawa, Akira Taniguchi, Shinichi Takase, Masayuki Maeda, Hajime Sakuma, Hiroyasu Akatsu, Yoshio Hashizume, Hidekazu Tomimoto
Microvascular lesions including cortical microinfarctions (CMIs) and cerebral lobar microbleeds (CMBs) are usually caused by cerebral amyloid angiopathy (CAA) in the elderly and are correlated with cognitive decline. However, their radiological-histopathological coincidence has not been revealed systematically with widely used 3-Tesla (3T) magnetic resonance imaging (MRI). The purpose of the present study is to delineate the histopathological background corresponding to MR images of these lesions. We examined formalin-fixed 10-mm thick coronal brain blocks from 10 CAA patients (five were also diagnosed with Alzheimer's disease, three with dementia with Lewy bodies, and two with CAA only) with dementia and six non CAA patients with neurodegenerative disease...
July 5, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28688098/the-attenuation-of-14-3-3%C3%AE-is-involved-in-the-caffeic-acid-blocked-lipopolysaccharide-stimulated-inflammatory-response-in-raw264-7-macrophages
#8
Ming Lu, Yi Dai, Miao Xu, Chi Zhang, Yuhong Ma, Ping Gao, Mengying Teng, Kailin Jiao, Guangming Huang, Jianping Zhang, Ye Yang, Zhiping Chu
Inflammation plays important roles in the initiation and progress of many diseases. Caffeic acid (CaA) is a naturally occurring hydroxycinnamic acid derivative, which shows hypotoxicity and diverse biological functions, including anti-inflammation. The molecular mechanisms involved in the CaA-inhibited inflammatory response are very complex; generally, the down-regulated phosphorylation of such important transcriptional factors, for example, nuclear factor κB (NF-κB) and signal transducers and activators of transcription-3 (STAT-3), plays an important role...
July 7, 2017: Inflammation
https://www.readbyqxmd.com/read/28687970/association-of-genetic-variations-in-rtn4-3-utr-with-risk-for-clear-cell-renal-cell-carcinoma
#9
Yan Pu, Peng Chen, Bin Zhou, Peng Zhang, Yanyun Wang, Yaping Song, Lin Zhang
Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. The present study was conducted to evaluate whether the TATC (rs71682980) and CAA (rs34917480) insertion/deletion polymorphisms of RTN4 3'-UTR are associated with clear cell renal cell carcinoma (ccRCC). These two polymorphisms were genotyped in 308 ccRCC patients and 466 healthy controls by polymerase chain reaction polyacrylamide gel electrophoresis (PCR-PAGE). Significantly reduced ccRCC risk was observed to be associated with the TATCins/ins genotype carriers (Versus TATCdel/del: adjusted OR 0...
July 7, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28677497/platelets-their-potential-contribution-to-the-generation-of-beta-amyloid-plaques-in-alzheimer-s-disease
#10
Christian Humpel
BACKGROUND: Alzheimer's disease is a severe neurodegenerative brain disorder, showing severe beta-amyloid depositions in the brain (plaques) and in vessels (cerebral amyloid angiopathy, CAA), tau pathology, neurodegeneration (and loss of acetylcholine), inflammation with reactive astrocytes and microglia and cerebrovascular damage, all resulting in memory loss. METHODS AND RESULTS: In this review I present a hypothesis that chronic vascular lesions and bleedings cause platelet overactivation and repair...
July 5, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28676206/manganese-testing-under-a-clean-air-act-test-rule-and-the-application-of-resultant-data-in-risk-assessments
#11
Darcie Smith, George M Woodall, Annie M Jarabek, William K Boyes
In the 1990's, the proposed use of methylcyclopentadienyl manganese tricarbonyl (MMT) as an octane-enhancing gasoline fuel additive led to concerns for potential public health consequences from exposure to manganese (Mn) combustion products in automotive exhaust. After a series of regulatory/legal actions and negotiations, the U.S. Environmental Protection Agency (EPA) issued under Clean Air Act (CAA) section 211(b) an Alternative Tier 2 Test Rule that required development of scientific information intended to help resolve uncertainties in exposure or health risk estimates associated with MMT use...
July 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28674386/metabolic-and-microbial-signatures-in-rat-hepatocellular-carcinoma-treated-with-caffeic-acid-and-chlorogenic-acid
#12
Zhan Zhang, Di Wang, Shanlei Qiao, Xinyue Wu, Shuyuan Cao, Li Wang, Xiaojian Su, Lei Li
Hepatocellular carcinoma (HCC) treatment remains lack of effective chemopreventive agents, therefore it is very attractive and urgent to discover novel anti-HCC drugs. In the present study, the effects of chlorogenic acid (ChA) and caffeic acid (CaA) on HCC induced by diethylnitrosamine (DEN) were evaluated. ChA or CaA could reduce the histopathological changes and liver injury markers, such as alanine transarninase, aspartate aminotransferase, alkaline phosphatase, total bile acid, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol...
July 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28667203/epidemiology-and-risk-factors-of-coronary-artery-aneurysm-in-taiwan-a-population-based-case-control-study
#13
Chein-Tang Fang, Yi-Ping Fang, Yaw-Bin Huang, Chen-Chun Kuo, Chung-Yu Chen
OBJECTIVES: Coronary artery aneurysm (CAA) is usually an asymptomatic and rare disease. There are limited epidemiological data for CAA in Asian populations and in the rest of the world. DESIGN: A retrospective case control study. SETTING: A population based, database study from Taiwan's National Health Insurance Research Database, between 2005 and 2011. PARTICIPANTS: CAA patients identified using International Classification of Diseases, ninth revision, clinical modification (ICD-9-CM) code 414...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28666576/assessment-of-coronary-artery-aneurysms-caused-by-kawasaki-disease-using-transluminal-attenuation-gradient-analysis-of-computerized-tomography-angiograms
#14
Noelia Grande Gutierrez, Olga Shirinsky, Nina Gagarina, Galina Lyskina, Ryuji Fukazawa, Shunichi Ogawa, Jane C Burns, Alison L Marsden, Andrew M Kahn
Patients with coronary artery aneurysms (CAAs) resulting from Kawasaki disease (KD) are at risk for thrombosis and myocardial infarction. Current guidelines recommend CAA diameter ≥8 mm as the criterion for initiating systemic anticoagulation. Transluminal attenuation gradient (TAG) analysis has been proposed as a noninvasive method for evaluating functional significance of coronary stenoses using computerized tomography angiography (CTA), but has not previously been used in CAA. We hypothesized that abnormal hemodynamics in CAA caused by KD could be quantified using TAG analysis...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28662948/cardiac-events-and-the-maximum-diameter-of-coronary-artery-aneurysms-in-kawasaki-disease
#15
Etsuko Tsuda, Nobuyuki Tsujii, Yosuke Hayama
OBJECTIVES: To clarify the occurrence of cardiac events based on the maximal diameter of the maximal coronary artery aneurysm (CAA) in Kawasaki disease (KD). STUDY DESIGN: Two hundred fourteen patients (160 male and 54 female) who had had at least 1 CAA in the selective coronary angiogram less than 100 days after the onset of KD were studied. We measured the maximal CAA diameters in the major branches of the initial coronary angiograms. Death, myocardial infarction and coronary artery revascularization were included as cardiac events in this study...
June 26, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28661830/the-diagnostic-utility-of-computer-assisted-auscultation-for-the-early-detection-of-cardiac-murmurs-of-structural-origin-in-the-periodic-health-evaluation
#16
Pierre L Viviers, Jo-Anne H Kirby, Jeandré T Viljoen, Wayne Derman
BACKGROUND: Identification of the nature of cardiac murmurs during the periodic health evaluation (PHE) of athletes is challenging due to the difficulty in distinguishing between murmurs of physiological or structural origin. Previously, computer-assisted auscultation (CAA) has shown promise to support appropriate referrals in the nonathlete pediatric population. HYPOTHESIS: CAA has the ability to accurately detect cardiac murmurs of structural origin during a PHE in collegiate athletes...
July 2017: Sports Health
https://www.readbyqxmd.com/read/28656474/dissecting-kawasaki-disease-a-state-of-the-art-review
#17
REVIEW
S M Dietz, D van Stijn, D Burgner, M Levin, I M Kuipers, B A Hutten, T W Kuijpers
Kawasaki disease (KD) is a pediatric vasculitis with coronary artery aneurysms (CAA) as its main complication. The diagnosis is based on the presence of persistent fever and clinical features including exanthema, lymphadenopathy, conjunctival injection, and changes to the mucosae and extremities. Although the etiology remains unknown, the current consensus is that it is likely caused by an (infectious) trigger initiating an abnormal immune response in genetically predisposed children. Treatment consists of high dose intravenous immunoglobulin (IVIG) and is directed at preventing the development of CAA...
June 27, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28647708/relapsing-cerebral-amyloid-angiopathy-related-inflammation-the-wax-and-the-wane
#18
Sharfaraz Salam, Mayooreshan Anandarajah, Sarah Al-Bachari, Piyali Pal, Jonathan Sussman, Hisham Hamdalla
Cerebral amyloid angiopathy-related inflammation (CAA-I) is a rare variant of cerebral amyloid angiopathy (CAA). Its precise pathophysiology remains uncertain and we currently have limited evidence on which immunosuppressive agents are the most effective in its treatment. The disease course of CAA-I disorders can vary from an isolated clinical event to recurrent episodes. We present a case of biopsy-confirmed CAA-I that gives insight into its potential relapsing nature and the challenges of its long-term management...
June 24, 2017: Practical Neurology
https://www.readbyqxmd.com/read/28639881/suspected-lateral-periodontal-cyst-presenting-concurrently-with-canine-acanthomatous-ameloblastoma-in-a-2-year-old-standard-poodle
#19
Jennifer Tjepkema, Cynthia Bell
Lateral periodontal cysts (LPCs) are odontogenic epithelial cysts composed of nonkeratinized epithelial cells that are in the category of developmental cysts, rather than inflammatory cysts. Lateral periodontal cysts are rare in both people and domestic animals; they are associated with vital teeth and located lateral to a tooth root. Lateral periodontal cysts are typically asymptomatic lesions that are characterized radiographically as a unilocular lucency with well-defined corticated borders. Canine acanthomatous ameloblastoma (CAA) is the most common odontogenic neoplasm in dogs and rarely presents as a cystic lesion...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28639826/imaging-appearance-of-advanced-chronic-adhesive-arachnoiditis-a-retrospective-review
#20
Tara L Anderson, Jonathan M Morris, John T Wald, Amy L Kotsenas
OBJECTIVE: Chronic adhesive arachnoiditis (CAA) is rare and has potentially devastating clinical consequences. The objective of this article is to review the clinical features of CAA and describe its appearance on imaging, to increase radiologists' awareness of this challenging diagnosis. MATERIALS AND METHODS: Twenty-nine cases of advanced CAA seen at our institution over 18 years (1995-2013) were retrospectively reviewed. Chart review was performed, with attention given to data on clinical presentation, suspected cause, and interventions performed...
June 22, 2017: AJR. American Journal of Roentgenology
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