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https://www.readbyqxmd.com/read/28538210/correlation-of-hamp-gene-polymorphisms-and-expression-with-the-susceptibility-and-length-of-hospital-stays-in-taiwanese-children-with-kawasaki-disease
#1
Ying-Hsien Huang, Kuender D Yang, Yu-Wen Hsu, Hsing-Fang Lu, Henry Sung-Ching Wong, Hong-Ren Yu, Hsing-Chun Kuo, Fu-Chen Huang, Mao-Hung Lo, Kai-Sheng Hsieh, Su-Fen Chen, Wei-Chiao Chang, Ho-Chang Kuo
Kawasaki disease (KD) is a form of systemic vasculitis. Regarding its pathogenesis, HAMP gene encoding hepcidin, which is significant for iron metabolism, has a vital function. In this study, we recruited a total of 381 KD patients for genotyping. Data from 997 subjects (500 subjects from cohort 1; 497 subjects from cohort 2) were used for analysis. Using TaqMan allelic discrimination, we determined five tag SNPs (rs916145, rs10421768, rs3817623, rs7251432, and rs2293689). Treatment outcome data related to such clinical phenotypes as coronary artery lesions (CAL), coronary artery aneurysms (CAA), and intravenous immunoglobulin (IVIG) effects were also collected...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28529940/coronary-artery-aneurysms-a-review-of-the-epidemiology-pathophysiology-diagnosis-and-treatment
#2
REVIEW
Sara Abou Sherif, Ozge Ozden Tok, Özgür Taşköylü, Omer Goktekin, Ismail Dogu Kilic
Coronary artery aneurysms (CAAs) are uncommon and describe a localized dilatation of a coronary artery segment more than 1.5-fold compared with adjacent normal segments. The incidence of CAAs varies from 0.3 to 5.3%. Ever since the dawn of the interventional era, CAAs have been increasingly diagnosed on coronary angiography. Causative factors include atherosclerosis, Takayasu arteritis, congenital disorders, Kawasaki disease (KD), and percutaneous coronary intervention. The natural history of CAAs remains unclear; however, several recent studies have postulated the underlying molecular mechanisms of CAAs, and genome-wide association studies have revealed several genetic predispositions to CAA...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28523359/arginine-cga-codons-as-a-source-of-nonsense-mutations-a-possible-role-in-multivariant-gene-expression-control-of-mrna-quality-and-aging
#3
Georgy A Romanov, Victor S Sukhoverov
Methylation of cytosine residues in DNA of higher eukaryotes, including humans, creates "hot spots" of C→T transitions in the genome. The predominantly methylated sequence in mammalian DNAs is CG (CpG). Among CG-containing codons, CGA codons for arginine are unique due to their ability to create stop codons TGA (UGA in mRNA) upon epigenetic-mediated mutation. As such nonsense mutations can have a strong adverse effect on the cell and organism, we have performed a study, on the example of human genes, aimed to characterise the anticipated effects of epigenetic-mediated nonsense mutations CGA→TGA in somatic cells...
May 18, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28521976/facile-synthesis-of-cellulose-derivatives-based-on-cellulose-acetoacetate
#4
Hongchen Liu, Liduo Rong, Bijia Wang, Zhiping Mao, Ruyi Xie, Hong Xu, Linping Zhang, Yi Zhong, Xiaofeng Sui
In the present work, cellulose acetoacetates (CAA) was used as a precursor for preparing diversely functionalized cellulose derivatives. Four amino-bearing compounds, namely hexylamine (HA), l-glutamic acid (Glu), cysteine (Cys), and tyramine (TA) were reacted with acetoacetyl groups providing alkyl-, carboxyl-, thiol-, or phenolic functionalized cellulose. The reaction was conducted under mild conditions without catalysts and UV light. The products were characterized with FT-IR, NMR and solubility measurement...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28512721/mid-term-risk-for-subclinical-atherosclerosis-and-chronic-myocarditis-in-children-with-kawasaki-disease-and-transient-coronary-abnormalities
#5
Mansingh Parihar, Surjit Singh, Pandiarajan Vignesh, Anju Gupta, Manojkumar Rohit
There is evidence for premature atherosclerosis and systemic arterial stiffening during follow-up of children with Kawasaki disease (KD) and coronary artery abnormalities (CAA). Moreover, patients with KD may also have subclinical myocardial involvement and inhomogeneous ventricular repolarization. The inhomogeneous ventricular repolarization manifests as increased QT dispersion on electrocardiography. There is a paucity of studies in endothelial dysfunction and QT dispersion in children with KD and transient CAA...
May 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28501057/mini-implant-retained-complete-overdenture-can-be-an-alternative-treatment-option-for-selected-patients
#6
Yongjeong Kim
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Complete overdentures retained by mini implants: A systematic review. Lemos CAA, Verri FR, de Souza Batista VE, Santiago JF Jr, Mello CC, Pellizzer EP. J Dent 2017;57:4-13. SOURCE OF FUNDING: The authors did not report any external sources of fund. TYPE OF STUDY/DESIGN: Systematic review.
June 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28501054/cement-and-screw-retained-implant-supported-restorations-showed-comparable-marginal-bone-loss-and-implant-survival-rate
#7
Ahmed Yaseen Alqutaibi
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Evaluation of cement-retained versus screw-retained implant-supported restorations for marginal bone loss: A systematic review and meta-analysis. Lemos CAA, de Souza Batista VE, de Faria Almeida DA, Júnior JFS, Verri FR, Pellizzer EP. J Prosthet Dent 2016; 115(4):419-27. SOURCE OF FUNDING: São Paulo Research Foundation (FAPESP), grant 2014/02490-8. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data...
June 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28498697/single-nodal-loop-of-accidental-degeneracies-in-minimal-symmetry-triclinic-caas_-3
#8
Y Quan, Z P Yin, W E Pickett
The existence of closed loops of degeneracies in crystals has been intimately connected with associated crystal symmetries, raising the following question: What is the minimum symmetry required for topological character, and can one find an example? Triclinic CaAs_{3}, in the space group P1[over ¯] with only a center of inversion, has been found to display, without need for tuning, a nodal loop of accidental degeneracies with topological character, centered on one face of the Brillouin zone that is otherwise fully gapped...
April 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28489317/pharmacogenomics-of-angiotensin-receptor-neprilysin-inhibitor-and-its-long-term-side-effects
#9
REVIEW
Chayakrit Krittanawong, Takeshi Kitai
The development of the promising agent sacubitril/valsartan, known as an angiotensin receptor blocker-neprilysin inhibitor (ARNI), to improve heart failure (HF) management, may benefit morbidity, mortality, and readmission rates in patients with HF. The PARADIGM-HF trial demonstrated that the ARNI can reduce morbidity and mortality in patients with heart failure with reduced ejection fraction (HFrEF), while ongoing PARAMOUNT and PARAGON-HF trials determined whether the ARNI has morbidity and mortality benefits in patients with heart failure with preserved ejection fraction (HFpEF)...
May 10, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28483590/giant-coronary-aneurysm-management-with-viabahn-covered-stent
#10
Tae-Hoon Kim, Ravi Marfatia, Juyong Lee, Michael Azrin
A 68year old female patient underwent coronary artery bypass surgery (CABG) 1year previously. At that time she had a giant coronary artery aneurysm (CAA) of the proximal right coronary artery and severe 3 vessel disease including a severe ostial right coronary artery stenosis, severe stenosis of the proximal and mid left anterior descending artery (LAD) and a totally occluded left circumflex artery. She underwent CABG including left internal mammary artery to LAD, aorto-saphenous venous graft (ASVG) to posterior descending artery and ASVG sequential to the first diagonal and obtuse marginal branch...
March 23, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28476760/distribution-of-lacunes-in-cerebral-amyloid-angiopathy-and-hypertensive-small-vessel-disease
#11
Marco Pasi, Gregoire Boulouis, Panagiotis Fotiadis, Eitan Auriel, Andreas Charidimou, Kellen Haley, Alison Ayres, Kristin M Schwab, Joshua N Goldstein, Jonathan Rosand, Anand Viswanathan, Leonardo Pantoni, Steven M Greenberg, M Edip Gurol
OBJECTIVE: To evaluate whether the burden of deep and lobar lacunes differs between patients with intracerebral hemorrhage (ICH) with definite/probable cerebral amyloid angiopathy (CAA) per the Boston criteria and hypertensive small vessel disease (HTN-SVD; ICH in basal ganglia, thalami, brainstem). METHODS: We defined lobar and deep lacunes similar to the topographic distribution used for ICH and cerebral microbleeds (CMBs). We then compared their distribution between patients with CAA-ICH and those with strictly deep CMB and ICH (HTN-ICH)...
May 5, 2017: Neurology
https://www.readbyqxmd.com/read/28476158/melicope-ptelefolia-leaf-extracts-exhibit-antioxidant-activity-and-exert-anti-proliferative-effect-with-apoptosis-induction-on-four-different-cancer-cell-lines
#12
Mohammad Faujul Kabir, Johari Mohd Ali, Mitra Abolmaesoomi, Onn Haji Hashim
BACKGROUND: Melicope ptelefolia is a well-known herb in a number of Asian countries. It is often used as vegetable salad and traditional medicine to address various ailments. However, not many studies have been currently done to evaluate the medicinal benefits of M. ptelefolia (MP). The present study reports antioxidant, anti-proliferative, and apoptosis induction activities of MP leaf extracts. METHOD: Young MP leaves were dried, powdered and extracted sequentially using hexane (HX), ethyl acetate (EA), methanol (MeOH) and water (W)...
May 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28473057/quality-of-systematic-reviews-of-the-foods-with-function-claims-registered-at-the-consumer-affairs-agency-web-site-in-japan-a-prospective-systematic-review
#13
REVIEW
Hiroharu Kamioka, Kiichiro Tsutani, Hideki Origasa, Takahiro Yoshizaki, Jun Kitayuguchi, Mikiko Shimada, Wentao Tang, Hiromi Takano-Ohmuro
The objective of this review was to assess the quality of systematic reviews (SRs) based on the Foods with Function Claims (FFC) registered at the Consumer Affairs Agency (CAA) Web site in Japan by AMSTAR checklist. Study design was a prospective SR of SRs based on the FFC registered at the CAA Web site in Japan. We searched the database from 1 April 2015 (starting date) through 27 October 2015 on the CAA Web site. A full quality appraisal of identified articles was made using the combined tool based on the AMSTAR checklist developed to assess the methodological quality of SRs...
April 2017: Nutrition Research
https://www.readbyqxmd.com/read/28467580/how-to-avoid-negative-appendectomies-can-us-achieve-this
#14
Kinyas Kartal, Pınar Yazıcı, Taner Mehmet Ünlü, Mehmet Uludağ, Mehmet Mihmanlı
BACKGROUND: Clinical diagnosis of acute appendicitis is based primarily on symptoms and physical findings. However, diagnosis of appendicitis is not always straightforward. The aim of this study was to demonstrate the diagnostic effectiveness of ultrasonography (US) in these cases in combination with white blood cell count (WBC) and C-reactive protein (CRP) level. METHODS: Retrospective analysis of data collected on 470 consecutive patients who underwent appendectomy at the same institution between January 2014 and January 2016 was conducted...
March 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28463681/cerebral-amyloid-angiopathy-in-down-syndrome-and-sporadic-and-autosomal-dominant-alzheimer-s-disease
#15
María Carmona-Iragui, Mircea Balasa, Bessy Benejam, Daniel Alcolea, Susana Fernández, Laura Videla, Isabel Sala, María Belén Sánchez-Saudinós, Estrella Morenas-Rodriguez, Roser Ribosa-Nogué, Ignacio Illán-Gala, Sofía Gonzalez-Ortiz, Jordi Clarimón, Frederick Schmitt, David K Powell, Beatriz Bosch, Albert Lladó, Michael S Rafii, Elizabeth Head, José Luis Molinuevo, Rafael Blesa, Sebastián Videla, Alberto Lleó, Raquel Sánchez-Valle, Juan Fortea
INTRODUCTION: We aimed to investigate if cerebral amyloid angiopathy (CAA) is more frequent in genetically determined than in sporadic early-onset forms of Alzheimer's disease (AD) (early-onset AD [EOAD]). METHODS: Neuroimaging features of CAA, apolipoprotein (APOE), and cerebrospinal fluid amyloid β (Aβ) 40 levels were studied in subjects with Down syndrome (DS, n = 117), autosomal-dominant AD (ADAD, n = 29), sporadic EOAD (n = 42), and healthy controls (n = 68)...
April 29, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28462804/sca2-family-presenting-as-typical-parkinson-s-disease-34-year-follow-up
#16
Young Eun Kim, Beomseok Jeon, Matthew J Farrer, Erika Scott, Ilaria Guella, Sung Sup Park, Jong Min Kim, Hye Young Park, Aryun Kim, Young Don Son, Zang Hee Cho
OBJECTIVE: We describe a Korean family in SCA2 with long-duration levodopa-responsive parkinsonism without cerebellar ataxia. METHODS: Clinical evaluation, genetic testing, and extensive imaging studies were done. RESULTS: All family members showed a typical Parkinson's disease phenotype without cerebellar ataxia for a long disease duration (up to 34 years). Genetic testing showed 40 CAG repeats and 4 CAA interruptions which is the longest repeat number among the families or patients manifesting with a parkinsonian phenotype without ataxia...
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28462514/relationship-between-white-matter-connectivity-loss-and-cortical-thinning-in-cerebral-amyloid-angiopathy
#17
Yael D Reijmer, Panagiotis Fotiadis, Andreas Charidimou, Susanne J van Veluw, Li Xiong, Grace A Riley, Sergi Martinez-Ramirez, Kristin Schwab, Anand Viswanathan, M Edip Gurol, Steven M Greenberg
Patients with cerebral amyloid angiopathy (CAA) show loss of white matter connectivity and cortical thinning on MRI, primarily in posterior brain regions. Here we examined whether a potential causal relationship exists between these markers of subcortical and cortical brain injury by examining whether changes in cortical thickness progress in tandem with changes in their underlying connections. Thirty-one patients with probable CAA with brain MRI at two time points were included (follow-up time: 1.3 ± 0...
April 30, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28459238/efficacy-and-advantages-of-modified-traditional-chinese-medicine-treatments-based-on-kidney-reinforcing-for-chronic-aplastic-anemia-a-randomized-controlled-clinical-trial
#18
Dijiong Wu, Yiping Shen, Baodong Ye, Bingmu Fang, Shengyun Lin, Zhilu Chen, Huifang Jiang, Changwei Feng, Lüyuan He, Yanting Gao, Yonglin Liu, Yonghua Liu, Jiajia Zhu, Liqiang Wu, Keding Shao, Shao Keding, Yuhong Zhou
OBJECTIVE: To compare the efficacy of modified treatments based on "kidney reinforcing" in the management of chronic aplastic anemia (CAA), and explore their advantages and specialties. METHODS: One hundred and eleven patients with CAA were randomly divided into three groups: kidney reinforcing alone (KA), "kidney reinforcing and Qi tonifying" (KQ), and "kidney reinforcing and blood circulation invigorating" (KC). Normal and positive control groups were also formed...
August 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/28451859/effect-of-correction-surgery-for-cervical-kyphosis-on-compensatory-mechanisms-in-overall-spinopelvic-sagittal-alignment
#19
Hiroshi Miyamoto, Kazuki Hashimoto, Terumasa Ikeda, Masao Akagi
PURPOSE: Progression of kyphotic deformity at the middle/lower cervical spine can cause difficulty with horizontal gaze, so compensation at other spinopelvic parts may occur. However, the precise mechanism remains unclear. The present study investigated the effect of correction surgery for cervical kyphosis on the compensatory mechanisms in overall spinopelvic sagittal alignment. METHODS: Forty-one patients, comprising 23 males and 18 females (mean age 67 years), underwent correction surgery for cervical kyphosis using the posterior screw-rod system...
April 27, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28447454/mycochemical-changes-induced-by-selenium-enrichment-in-p-%C3%A2-ostreatus-fruiting-bodies
#20
Jorge A Carrasco-Gonzalez, Sergio O Serna-Saldívar, Janet A Gutierrez-Uribe
The effects of selenium enrichment on the biological efficiency, phenolic compounds, amino acid profile, antioxidant capacity, and cellular antioxidant activity (CAA) were evaluated in Pleurotus ostreatus fruiting bodies (FB) harvested during three sequential flushes. Sodium selenate was used to reach selenium content of 17.5 or 5.8 mg/kg in the sorghum straw substrate. Biological efficiency and total selenium content increased. One of the main differences among treatments was in ergothioneine content, an indicator of oxidative stress that was positively related with valine and isoleucine contents and negatively related to leucine and phenylalanine...
May 10, 2017: Journal of Agricultural and Food Chemistry
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