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Cristina Cruz, Teresa Pinho, Carla Sousa, Cláudia Camila Dias, José Silva Cardoso, Maria Júlia Maciel
BACKGROUND: Late after tetralogy of Fallot (TOF) repair some patients exhibit aortic dilatation and stiffness. Noninvasive assessment of aortic stiffness could contribute to understand this aortopathy and may be important in risk stratification for major aortic event. METHODS: We included prospectively 82 adults after TOF repair and 41 age- and sex-matched normal controls. Aortic diameters were measured by two-dimensional transthoracic echocardiography and the aortic z-score was estimated...
June 13, 2018: Echocardiography
Lisa Ruth-Sahd, Melissa Schneider
When a patient presents with stroke-type symptoms, the correct diagnosis is imperative to determine appropriate treatment. Cerebral amyloid angiopathy (CAA), a buildup of amyloid proteins on the brain artery walls, is a cause of intracerebral hemorrhage. Improved diagnostic criteria and enhanced neuroimaging have resulted in earlier detection of CAA, which will hopefully lead to better outcomes for these patients. More research is being conducted, and neuroscience nurses need to stay informed about this condition to be able to appropriately care for and educate their patients who are diagnosed with CAA...
June 12, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
J R SoutoMaior, Sld de Moraes, Caa Lemos, Bc do E Vasconcelos, Majr Montes, E P Pellizzer
OBJECTIVE: A systematic review and meta-analyses were performed to evaluate the efficacy of tooth color change and sensitivity of teeth following in-office bleaching with and without light gel activation in adult patients. METHODS: This review was registered at PROSPERO (CRD 42017060574) and is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Electronic systematic searches of PubMed/MEDLINE, Web of Science, and the Cochrane Library were conducted for published articles...
June 12, 2018: Operative Dentistry
Finnbogi R Thormodsson, Ingvar H Olafsson, Dadi Th Vilhjalmsson
Cerebral amyloid angiopathy (CAA) results from amyloid accumulation within arteries of the cerebral cortex and leptomeninges. This condition is age-related, especially prevalent in Alzheimer's disease (AD), and the main feature of certain hereditary disorders (i.e., HCHWA-I). The vascular smooth muscle cells (VSMCs) appear to play a vital role in the development of CAA, which makes them well suited as an experimental model to study the disease and screen for possible remedies. We describe two different methods for isolating and culturing human VSMCs: First, using the human umbilical cord as an easy source of robust cells, and secondly, using brain tissue that provides the proper cerebral VSMCs, but is more problematic to work with...
2018: Methods in Molecular Biology
Fabiana Firetti, Alexandre Rizzo Zuntini, Jonas Weismann Gaiarsa, Renata Souza Oliveira, Lúcia G Lohmann, Marie-Anne Van Sluys
PREMISE OF THE STUDY: Bignoniaceae is an important component of neotropical forests and a model for evolutionary and biogeographical studies. A previous combination of molecular markers and morphological traits improved the phylogeny of the group. Here we demonstrate the value of next-generation sequencing (NGS) to assemble the chloroplast genome of eight Anemopaegma species and solve taxonomic problems. METHODS: Three NGS platforms were used to sequence total DNA of Anemopaegma species...
October 2017: American Journal of Botany
Kosuke Kusakabe, Akihiro Inoue, Shirabe Matsumoto, Mie Kurata, Riko Kitazawa, Hideaki Watanabe, Takeharu Kunieda
INTRODUCTION: Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare and treatable variant of cerebral amyloid angiopathy, lacks specific imaging and clinical features, and requires invasive brain biopsy to confirm the diagnosis. We report the case of a patient with nonconvulsive status epilepticus (NCSE) caused by CAA-ri in the right occipital lobe. PRESENTATION OF CASE: A 78-year-old man with a history of hypertension and rheumatoid arthritis was admitted to our hospital following an episode of seizures...
May 29, 2018: International Journal of Surgery Case Reports
Arianna Novati, Libo Yu-Taeger, Irene Gonzalez Menendez, Leticia Quintanilla Martinez, Huu Phuc Nguyen
BACKGROUND: Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene, which results in brain neurodegeneration and peripheral pathology affecting different organs including testis. Patients with HD suffer from motor and cognitive impairment, and multiple psychiatric symptoms. Among behavioral abnormalities in HD, sexual disturbances have often been reported, but scarcely investigated in animal models. The BACHD rat model of HD carries the human full-length mutated HTT (mHTT) genomic sequence with 97 CAG-CAA repeats and displays HD-like alterations at neuropathological and behavioral level...
2018: PloS One
Yuling Shan, Zhijun Sui, Yian Zhu, Jinghong Zhou, Xinggui Zhou, De Chen
A strategy for making metal clusters encapsulated inside microporous solids selectively accessible to reactant molecules by manipulating the molecular sieve size and affinity for adsorbed molecule expands the catalytic capabilities of these materials to reactions demanding high selectivity and stability. Selective hydrogen combustion was achieved over Pt clusters encapsulated in LTA zeolite (KA, NaA, CaA) in a propene-rich mixture obtained from propane dehydrogenation and showed obvious pore-size dependent selectivity and coking rate...
June 6, 2018: Angewandte Chemie
María E Solesio, Pablo M Peixoto, Ludovic Debure, Stephen M Madamba, Mony J de Leon, Thomas Wisniewski, Evgeny V Pavlov, Silvia Fossati
Mounting evidence suggests that mitochondrial dysfunction plays a causal role in the etiology and progression of Alzheimer's disease (AD). We recently showed that the carbonic anhydrase inhibitor (CAI) methazolamide (MTZ) prevents amyloid β (Aβ)-mediated onset of apoptosis in the mouse brain. In this study, we used MTZ and, for the first time, the analog CAI acetazolamide (ATZ) in neuronal and cerebral vascular cells challenged with Aβ, to clarify their protective effects and mitochondrial molecular mechanism of action...
June 5, 2018: Aging Cell
Yasuhiko Hayashi, Masahiro Oishi, Yasuo Sasagawa, Daisuke Kita, Kazuto Kozaka, Mitsutoshi Nakada
INTRODUCTION: Chiari malformation type I (CM-I) is a well-known hindbrain disorder in which the cerebellar tonsils protrude through the foramen magnum. The soft tissues, including the transverse ligament and the tectorial membrane at the retro-odontoid space, can compress the cervicomedullary junction if they become hypertrophic. METHODS: Twenty-two symptomatic CM-I patients (aged 5 to 19 years) were treated between 2007 and 2017 at our institute. The retro-odontoid soft tissue was evaluated using T2-weighted magnetic resonance imaging...
June 2, 2018: World Neurosurgery
Andrew C Robinson, Yvonne S Davidson, Michael A Horan, Neil Pendleton, David M A Mann
The neuropathological changes responsible for cognitive impairment and dementia remain incompletely understood. Longitudinal studies with a brain donation end point allow the opportunity to examine relationships between cognitive status and neuropathology. We report on the first 97 participants coming to autopsy with sufficient clinical information from The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age. This study began in 1983 and recruited 6,542 healthy individuals between 1983 and 1994, 312 of whom consented to brain donation...
May 28, 2018: Journal of Alzheimer's Disease: JAD
Dimitri Renard, Lavinia Tatu, Eric Thouvenot
BACKGROUND: Cerebral microbleeds (CMBs) observed in hypertension-related arteriolosclerosis tend to occur in the supratentorial deep gray matter, whereas those in cerebral amyloid angiopathy (CAA) typically show a supratentorial lobar distribution. Recently, superficial spontaneous cerebellar intracerebral hemorrhage has been shown to be associated with strictly lobar CMBs. Few data exist on infratentorial CMBs in CAA. The purpose of this study was to describe the incidence, number, and characteristics of infratentorial CMBs in patients with CAA...
May 31, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
David C Hondius, Kristel N Eigenhuis, Tjado H J Morrema, Roel C van der Schors, Pim van Nierop, Marianna Bugiani, Ka Wan Li, Jeroen J M Hoozemans, August B Smit, Annemieke J M Rozemuller
Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) deposits as plaques in the parenchyma and in the walls of cortical and leptomeningeal blood vessels of the brain called cerebral amyloid angiopathy (CAA). It is suggested that CAA type-1, which refers to amyloid deposition in both capillaries and larger vessels, adds to the symptomatic manifestation of AD and correlates with disease severity. Currently, CAA cannot be diagnosed pre-mortem and disease mechanisms involved in CAA are elusive. To obtain insight in the disease mechanism of CAA and to identify marker proteins specifically associated with CAA we performed a laser dissection microscopy assisted mass spectrometry analysis of post-mortem human brain tissue of (I) AD cases with only amyloid deposits in the brain parenchyma and no vascular related amyloid, (II) AD cases with severe CAA type-1 and no or low numbers of parenchymal amyloid deposits and (III) cognitively healthy controls without amyloid deposits...
June 4, 2018: Acta Neuropathologica Communications
Wei-Lun Lin, Yu-Ruey Chen, Chun-Ting Lai, Shinya Yamada, Shin-Huei Liu, Yu-Hui Chou, Yun-Ching Fu, Cheryl C H Yang, Terry B J Kuo, Li-Wei Lo, Shih-Ann Chen
BACKGROUND: Sympathetic hyperactivity and poor sleep quality are reported in myocardial infarction (MI) patients and angiotensin-converting enzyme inhibitors (ACEI) can improve long-term survival in these patients. We aimed to evaluate ACEI effects on cardiac autonomic activity (CAA) and disordered sleep patterns in ambulatory rats after MI. METHODS: Polysomnographic recording was performed in sham (n = 8) and MI (n = 9) male rats during normal daytime sleep before and after captopril treatment...
May 1, 2018: Sleep Medicine
Antoine Rousseau, Céline Terrada, Sara Touhami, Emmanuel Barreau, Pierre-Raphaël Rothschild, Sophie Valleix, Farida Benoudiba, Marie-Hélène Errera, Cécile Cauquil, Anne Guiochon-Mantel, David Adams, Marc Labetoulle
PURPOSE: To describe abnormalities in choroidal and retinal vasculature associated with Val30Met familial transthyretin amyloidosis (V30M-FTA) using fluorescein and indocyanine green (ICG) angiography. DESIGN: Prospective, cross-sectional study. METHODS: This study was conducted at the French National Reference Center for FTA. We included 18 consecutive genetically confirmed V30M-FTA patients (36 eyes) who underwent complete neurological examination, including staging with Polyneuropathy Disability (PND) score, and complete ophthalmic evaluation, including staging of intraocular amyloid deposits, fluorescein (FA) and ICG angiograms (ICG-A)...
May 30, 2018: American Journal of Ophthalmology
Hatice Gül Dursun, Hüseyin Osman Yılmaz, Recep Dursun, Sevsen Kulaksızoğlu
Psoriasis is a common, chronic, and autoimmune skin disease in which dysregulation of immune cells, particularly T cells, is thought to play an important role in the pathogenesis. Cytotoxic T lymphocyte antigen-4 (CTLA-4) expressed only on activated T cells is an immunoregulatory molecule and plays a role in the pathogenesis of autoimmune disorders. We aimed to determine whether CTLA-4 gene polymorphisms are associated with development and/or clinical features of psoriasis vulgaris (Pv). Genotyping of SNPs (-318C>T, +49A>G, and CT60A>G) in CTLA-4 gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 103 Pv patients and 102 controls...
2018: Journal of Immunology Research
Monika Baranowska, Klaudia Suliborska, Wojciech Chrzanowski, Barbara Kusznierewicz, Jacek Namieśnik, Agnieszka Bartoszek
Redox homeostasis involves factors that ensure proper function of cells. The excess reactive oxygen species (ROS) leads to oxidative stress and increased risk of oxidative damage to cellular components. In contrast, upon reductive stress, insufficient ROS abundance may result in faulty cell signalling. It may be expected that dietary antioxidants, depending on their standard reduction potentials (E°), will affect both scenarios. In our study, for the first time, we systematically tested the relationship among E°, chemical properties, and biological effects in HT29 cells for a series of structurally different catechins and a major endogenous antioxidant - glutathione (GSH), at both physiological and dietary concentrations...
May 14, 2018: Redox Biology
Muthukumaran C, Kanmani B R, Sharmila G, Manoj Kumar N, Shanmugaprakash M
The sequential optimization of carboxymethylation of pectin by Plackett-Burman (PB) design and response surface methodology (RSM) was reported in this study. PB design was employed to screen the six process variables (ethanol concentration, liquid-polymer ratio, NaOH concentration, CAA concentration, temperature and time). Central composite design (CCD) was used to study the interaction effects of ethanol concentration, NaOH concentration, CAA concentration and time on degree of substitution (DS) in carboxymethylated pectin (CMP)...
August 15, 2018: Carbohydrate Polymers
Jamal Janjua, Esosa G Odigie-Okon, Premnauth Rabindranauth, Richard J Wittchow, Aiman Riaz
Giant coronary artery aneurysms (CAAs) are defined as having a diameter of greater than 2 cm. We report a case of an 82-year-old male with severe aortic stenosis incidentally diagnosed with giant right coronary artery aneurysm (gRCAA) while undergoing evaluation for transcather aortic valve replacement (TAVR). It was causing a mass effect on the right cardiac chambers but was otherwise asymptomatic. Our patient was successfully treated with surgical excision of aneurysm with concomitant coronary artery bypass grafting (CABG) and surgical aortic valve replacement (SAVR)...
2018: Case Reports in Cardiology
Stewart A Weber, Ranish K Patel, Helmi L Lutsep
Cerebral amyloid angiopathy (CAA) is characterized by the pathologic deposition of amyloid-beta within cortical and leptomeningeal arteries, arterioles, capillaries and, in rare cases, the venules of the brain. It is often associated with the development of lobar intracerebral hemorrhages but may cause other neurologic symptoms or be asymptomatic. Magnetic resonance imaging characteristics, such as lobar microbleeds, support a diagnosis of CAA and assist with hemorrhage risk assessments. Immunosuppressants are used to treat rarer inflammatory forms of CAA...
May 24, 2018: Expert Review of Neurotherapeutics
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