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https://www.readbyqxmd.com/read/28945045/-real-world-analysis-to-explore-clinical-features-of-shenxiong-glucose-injection-combined-with-other-medications
#1
Gui-Qian Wang, Yan-Ming Xie, Huan Liu, Yin Zhang, Ping-Ping Jia, Yan Zhuang
To explore the real world clinical medication and combination characteristics of Shenxiong glucose injection. The basic information of patients with Shenxiong glucose injection, traditional Chinese and western medicine diagnosis information, doctor advice information and laboratory test information from the hospital information system(HIS) of 19 tertiary hospitals in China. Apriori algorithm was adopted to establish the models, and Clementine 12.0 was used for correlation analysis to analyze the real world clinical medication and combination characteristics of Shenxiong glucose injection...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945022/-progress-of-gene-editing-technologies-and-prospect-in-traditional-chinese-medicine
#2
REVIEW
Yan-Yan Ma, Jing-Zhe Li, Er-Ning Gao, Dan Qian, Ju-Ying Zhong, Chang-Zhen Liu
Gene editing is a kind of technologies that makes precise modification to the genome. It can be used to knock out/in and replace the specific DNA fragment, and make accurate gene editing on the genome level. The essence of the technique is the DNA sequence change with use of non homologous end link repair and homologous recombination repair, combined with specific DNA target recognition and endonuclease.This technology has wide range of development prospects and high application value in terms of scientific research, agriculture, medical treatment and other fields...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945005/differential-expression-of-myometrial-ap-1-proteins-during-gestation-and-labour
#3
Lubna Nadeem, Tali Farine, Anna Dorogin, Elzbieta Matysiak-Zablocki, Oksana Shynlova, Stephen Lye
Preterm labour (PTL) is a leading cause of perinatal mortality and postnatal morbidity. Contractions of the uterine muscle (myometrium) that determine the onset of labour depend on the expression of contraction-associated proteins (CAPs, i.e. connexin43) regulated by dimeric AP-1 transcription factors. Here, we examined subcellular (by immunoblotting) and tissue expression (by immunohistochemistry) of myometrial AP-1 proteins (cJUN, JUNB, JUND, cFOS, FOSB, FRA1, FRA2) throughout gestation and TL in different species (mouse, rat and human)...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28945001/organ-on-a-chip-technology-for-reproducing-multiorgan-physiology
#4
REVIEW
Seung Hwan Lee, Jong Hwan Sung
In the drug development process, the accurate prediction of drug efficacy and toxicity is important in order to reduce the cost, labor, and effort involved. For this purpose, conventional 2D cell culture models are used in the early phase of drug development. However, the differences between the in vitro and the in vivo systems have caused the failure of drugs in the later phase of the drug-development process. Therefore, there is a need for a novel in vitro model system that can provide accurate information for evaluating the drug efficacy and toxicity through a closer recapitulation of the in vivo system...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944865/middle-pregnancy-ultrasound-screening-for-fetal-chromosomal-diseases
#5
Li Liu, Ping Zhou, Zemin Cao, Xiaojun Tan
Prenatal examinations, including serological screening and ultrasound screening, are the methods determining a risk of fetal chromosomal disease. The current study is aimed to assess whether ultrasound screening can effectively assist the screening for fetal chromosomal disease among pregnant women with a single abnormal serum marker. Following serologic screening, pregnant women at 18‑32 weeks underwent systematic fetal ultrasound analysis. In this study, 99 pregnant women with an abnormal serum marker and fetal ultrasound abnormalities underwent prenatal diagnosis of amniotic fluid or umbilical cord blood, with confirmation by pathological examination performed following birth or induced labor...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944746/using-two-sex-life-tables-to-determine-fitness-parameters-of-four-bactrocera-species-diptera-tephritidae-reared-on-a-semi-artificial-diet
#6
W Jaleel, J Yin, D Wang, Y He, L Lu, H Shi
Fruit flies in the genus Bactrocera are global, economically important pests of agricultural food crops. However, basic life history information about these pests, which is vital for designing more effective control methods, is currently lacking. Artificial diets can be used as a suitable replacement for natural host plants for rearing fruit flies under laboratory conditions, and this study reports on the two-sex life-table parameters of four Bactrocera species (Bactrocera correcta, Bactrocera dorsalis, Bactrocera cucurbitae, and Bactrocera tau) reared on a semi-artificial diet comprising corn flour, banana, sodium benzoate, yeast, sucrose, winding paper, hydrochloric acid and water...
September 25, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28944724/rapid-prototyping-of-a-cyclic-olefin-copolymer-microfluidic-device-for-automated-oocyte-culturing
#7
Miguel Berenguel-Alonso, Maria Sabés-Alsina, Roser Morató, Oriol Ymbern, Laura Rodríguez-Vázquez, Oriol Talló-Parra, Julián Alonso-Chamarro, Mar Puyol, Manel López-Béjar
Assisted reproductive technology (ART) can benefit from the features of microfluidic technologies, such as the automation of time-consuming labor-intensive procedures, the possibility to mimic in vivo environments, and the miniaturization of the required equipment. To date, most of the proposed approaches are based on polydimethylsiloxane (PDMS) as platform substrate material due to its widespread use in academia, despite certain disadvantages, such as the elevated cost of mass production. Herein, we present a rapid fabrication process for a cyclic olefin copolymer (COC) monolithic microfluidic device combining hot embossing-using a low-temperature cofired ceramic (LTCC) master-and micromilling...
October 2017: SLAS Technology
https://www.readbyqxmd.com/read/28944721/early-life-sugar-consumption-has-long-term-negative-effects-on-memory-function-in-male-rats
#8
Emily E Noble, Ted M Hsu, Joanna Liang, Scott E Kanoski
OBJECTIVES: Added dietary sugars contribute substantially to the diet of children and adolescents in the USA, and recent evidence suggests that consuming sugar-sweetened beverages (SSBs) during early life has deleterious effects on hippocampal-dependent memory function. Here, we test whether the effects of early-life sugar consumption on hippocampal function persist into adulthood when access to sugar is restricted to the juvenile/adolescent phase of development. METHODS: Male rats were given ad libitum access to an 11% weight-by-volume sugar solution (made with high fructose corn syrup-55) throughout the adolescent phase of development (post-natal day (PN) 26-56)...
September 25, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28944715/balance-training-enhances-motor-coordination-during-a-perturbed-side-step-cutting-task
#9
Anderson Souza Oliveira, Priscila de Brito Silva, Morten Enemark Lund, Dario Farina, Uwe Gustav Kersting
Study Design Controlled laboratory study. Background Balance training (BTR) may improve motor coordination, however little is known about the changes in motor coordination during unexpected perturbations to postural control following BTR. Objectives To study the effects of BTR on motor coordination and knee mechanics during perturbed side-step cutting maneuvers in healthy adults. Methods Twenty-six healthy men were randomly assigned to a training group (TG) or control (CG). Before BTR, subjects performed unperturbed, 90° side-step cutting maneuvers and one unexpected perturbed cut (10-cm translation of a moveable platform)...
September 23, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28944703/hospital-costs-for-patients-with-lower-extremity-cellulitis-a-retrospective-population-based-study
#10
Douglas Challener, Jasmine Marcelin, Sue Visscher, Larry Baddour
BACKGROUND: Hospital admissions for non-purulent lower extremity cellulitis (NLEC) are common and can be prolonged and costly. Newer treatment options and preventive strategies are expected to result in cost savings before implementation, but few studies have quantified the cost of conventional treatment. METHODS: Using the Rochester Epidemiology Project, the incidence of NLEC in Olmsted County, MN in 2013 was 176.6 per 100,000 persons. The subset of patients who required hospitalization for NLEC in 2013 was determined...
September 23, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/28944651/salivary-immunoglobulin-a-in-healthy-adolescent-females-effects-of-maximal-exercise-physical-activity-body-composition-and-diet
#11
Hermann J Engels, Bradley J Kendall, Mariane M Fahlman, Neha P Gothe, Kelsey C Bourbeau
BACKGROUND: The primary purpose of this study was to examine the effect of acute maximal exercise (VO2max test) on salivary immunoglobulin A (SIgA) responses in adolescent females. A secondary aim was to examine the relationship between resting SIgA levels and VO2max, physical activity, body composition, and diet. METHODS: Fifty healthy female adolescents completed a laboratory based VO2max test, assessment of body composition via hydrodensitometry, a validated physical activity questionnaire (PAQ- A), and a 3-day food diary...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28944605/a-comparison-of-two-screening-tools-for-paediatric-obstructive-sleep-apnea
#12
Asmaa M Abumuamar, Sharon A Chung, Gili Kadmon, Colin M Shapiro
Untreated obstructive sleep apnea in children is associated with significant medical and psychological morbidities. Polysomnographic testing is the gold-standard method for diagnosis of obstructive sleep apnea. However, laboratory-based polysomnography is expensive and associated with a substantial healthcare burden. Thus, a simple valid tool to accurately identify those at high risk of obstructive sleep apnea is essential. We performed a retrospective cross-sectional study of children referred to the Youthdale Child and Adolescent Sleep Clinic...
September 25, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28944502/immune-reconstitution-inflammatory-syndrome-in-non-hiv-immunosuppressed-patients
#13
REVIEW
Hirohiko Sueki, Yoshiko Mizukawa, Yumi Aoyama
Immune reconstitution inflammatory syndrome (IRIS) represents a clinical phenomenon of immune-mediated inflammation against various antigens, including pathogenic microorganisms, drugs and unknown autoantigens, during recovery from immunosuppressed conditions. IRIS has become well recognized in HIV-infected populations. However, IRIS has seldom been recognized in HIV-negative immunocompromised patients. In the last 15 years, the immunopathogenesis of drug-induced hypersensitivity syndrome (DIHS) has been largely determined...
September 25, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28944469/probing-early-motion-processing-with-eye-movements-differences-of-vestibular-migraine-migraine-with-and-without-aura-in-the-attack-free-interval
#14
S Rogalinski, H A Rambold
BACKGROUND: Migraineurs, in between headache attacks, have a different sensitivity to sensory motion stimuli compared to non-migraineurs. METHODS: This cross-sectional laboratory study examines the motion processing in migraineurs using ocular following responses (OFR) elicited by large field random dot patterns and open-loop smooth pursuit eye movements (PS) elicited by a single target moving on a homogenous background. Eye movements were recorded with a video-oculographic system (EyeSeeTec(®) ) and stimuli presented on a CRT at 100 Hz repetition rate to horizontal stimuli of a velocity of 2...
September 25, 2017: Headache
https://www.readbyqxmd.com/read/28944437/no-effect-of-insect-repellents-on-the-behaviour-of-lymnaea-stagnalis-at-environmentally-relevant-concentrations
#15
Patrick Fink, Eric von Elert
Insect repellents are widely applied to various materials and to both human and animal skin to deter mosquitoes and ticks. The most common deterrent compounds applied are DEET, EBAAP and icaridin (picaridin, Bayrepel). Due to their extensive application, these repellents are frequently detected in surface waters in considerable concentrations. As these compounds are designed to alter invertebrates' behaviour rather than to intoxicate them, we hypothesised that insect repellents have the potential to modify the natural behaviour of non-target invertebrates in natural freshwater bodies...
September 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28944374/performance-of-cad-cam-monolithic-ceramic-implant-supported-restorations-bonded-to-titanium-inserts-a-systematic-review
#16
Julian Conejo, Toyoaki Kobayashi, Evantia Anadioti, Markus B Blatz
AIMS: This review assessed the available evidence on the performance of CAD/CAM monolithic implant-supported restorations bonded to titanium (Ti) inserts and bases, which has become a popular concept. MATERIALS AND METHODS: An electronic and manual search of PubMed databases was conducted to identify studies published in English between 2000 and 2016 on the performance of monolithic ceramic implant restorations with Ti inserts. RESULTS: The initial search revealed 505 titles...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28944329/course-of-sepsis-in-rats-with-thyroid-dysfunction
#17
Halil İbrahim Taşcı, Mehmet Erikoğlu, Hatice Toy, Adnan Karaibrahimoğlu
OBJECTIVE: Numerous studies show the relationship between sepsis and thyroid hormones. Virtually all these studies investigate changes in post-sepsis thyroid hormones and the relationship between these changes and the progression of the disease. Our aim in this study was to investigate the progression of sepsis in rats with thyroid dysfunction. MATERIAL AND METHODS: The study involved four groups, each containing seven female Wistar albino rats: Group 1: Sham, Group 2: Control (Sepsis), Group 3: Hyperthyroidism-Sepsis, and Group 4: Hypothyroidism-Sepsis...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28944300/proteomic-analysis-of-extracellular-vesicles-from-a-plasmodium-falciparum-kenyan-clinical-isolate-defines-a-core-parasite-secretome
#18
Abdirahman Abdi, Lu Yu, David Goulding, Martin K Rono, Philip Bejon, Jyoti Choudhary, Julian Rayner
BACKGROUND: Many pathogens secrete effector molecules to subvert host immune responses, to acquire nutrients, and/or to prepare host cells for invasion. One of the ways that effector molecules are secreted is through extracellular vesicles (EVs) such as exosomes. Recently, the malaria parasite P. falciparum has been shown to produce EVs that can mediate transfer of genetic material between parasites and induce sexual commitment. Characterizing the content of these vesicles may improve our understanding of P...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28944287/detection-of-pentosidine-cross-links-in-cell-secreted-decellularized-matrices-using-time-resolved-fluorescence-spectroscopy
#19
Debika Mitra, Hussain Fatakdawala, Michael Nguyen-Truong, Amy Creecy, Jeffry Nyman, Laura Marcu, J Kent Leach
Hyperglycemia-mediated, nonenzymatic collagen cross-links such as pentosidine (PENT) can have deleterious effects on cellular interactions with the extracellular matrix (ECM). Present techniques to quantify PENT are limited, motivating the need for improved methods to study the accumulation and contribution of PENT toward diabetic clinical challenges such as impaired bone healing. Current methods for studying PENT are destructive, laborious, and frequently employ oversimplified collagen films that lack the complexity of the native ECM...
September 11, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28944274/time-motion-analysis-as-a-novel-approach-for-evaluating-the-impact-of-environmental-heat-exposure-on-labor-loss-in-agriculture-workers
#20
Leonidas G Ioannou, Lydia Tsoutsoubi, George Samoutis, Lucka Kajfez Bogataj, Glen P Kenny, Lars Nybo, Tord Kjellstrom, Andreas D Flouris
Introduction: In this study we (i) introduced time-motion analysis for assessing the impact of workplace heat on the work shift time spent doing labor (WTL) of grape-picking workers, (ii) examined whether seasonal environmental differences can influence their WTL, and (iii) investigated whether their WTL can be assessed by monitoring productivity or the vineyard manager's estimate of WTL. Methods: Seven grape-picking workers were assessed during the summer and/or autumn via video throughout four work shifts...
2017: Temperature: Multidisciplinary Biomedical Journal
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