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https://www.readbyqxmd.com/read/28422556/the-acute-effects-of-breaking-up-seated-office-work-with-standing-or-light-intensity-walking-on-interstitial-glucose-concentration-a-randomised-crossover-trial
#1
Laura A Brocklebank, Rob C Andrews, Angie Page, Catherine L Falconer, Sam Leary, Ashley Cooper
BACKGROUND: The aim of this randomised, three-period, three-treatment crossover trial was to examine the acute effects of regularly breaking up seated office work with short bouts of standing or light-intensity walking on postprandial interstitial glucose concentration. METHODS: Seventeen middle-aged office workers performed three five-hour trial conditions at their workplace in a random order: 1) uninterrupted sitting; 2) sitting interrupted by two minutes of standing every 20 minutes; and 3) sitting interrupted by two minutes of light-intensity walking every 20 minutes...
April 19, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28344659/comparison-of-in-hospital-glycemic-variability-and-admission-blood-glucose-in-predicting-short-term-outcomes-in-non-diabetes-patients-with-st-elevation-myocardial-infarction-underwent-percutaneous-coronary-intervention
#2
Shu-Hua Mi, Gong Su, Hong-Xia Yang, Yun Zhou, Lei Tian, Tao Zhang, Hong Tao
AIMS: Admission hyperglycemia is associated with increased mortality and major adverse cardiac events (MACE) in patients with or without diabetes mellitus after acute myocardial infarction (AMI). However, effects of glycemic variability (GV) on outcomes of non-diabetes patients with AMI still remains unclear. The aim of this study is to compare the prognostic value of in-hospital GV with admission blood glucose (ABG) for 3-month MACE in non-diabetes patients with ST elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28332406/continuous-glucose-monitor-interference-with-commonly-prescribed-medications
#3
Ananda Basu, Michael Q Slama, Wayne T Nicholson, Loralie Langman, Thomas Peyser, Rickey Carter, Rita Basu
BACKGROUND: Reliability of continuous glucose monitors (CGM) is a prerequisite for therapeutic dosing of insulin without the need for confirmatory blood glucose meter measurements. Interference of CGMs with commonly prescribed substances has not been extensively evaluated. METHODS: We sought to undertake a novel pilot study to determine the susceptibility of FDA-approved CGM systems (Medtronic Guardian Sof-Sensor, Dexcom G4 Platinum) to erroneous readings in the presence of common medications...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28293303/characteristics-of-glucose-metabolism-indexes-and-continuous-glucose-monitoring-system-cgms-in-patients-with-insulinoma
#4
Weijun Gu, Yixin Liu, Hongyan Liu, Guoqing Yang, Qinghua Guo, Jin Du, Nan Jin, Li Zang, Zhaohui Lv, Jianming Ba, Yiming Mu, Jingtao Dou
AIMS: Analyze the clinical applicability of glucose metabolism indexes and continuous glucose monitoring data on the qualitative diagnosis of insulinoma. METHODS: Involve 22 patients with insulinoma (insulinoma group), 11 patients with hypoglycemia (hypoglycemia group) and 31 people with normal glucose tolerance (control group). HbA1c, fasting blood glucose (FBG), insulin (FINS) and C-peptide (FCP) was tested. Using CGMS to monitor the blood glucose for three consecutive days and selecting the monitoring data of 24 h thereof, figuring out, with the aid of EasyGV Version 9...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28264188/privacy-and-security-issues-surrounding-the-protection-of-data-generated-by-continuous-glucose-monitors
#5
Katherine E Britton, Jennifer D Britton-Colonnese
Being able to track, analyze, and use data from continuous glucose monitors (CGMs) and through platforms and apps that communicate with CGMs helps achieve better outcomes and can advance the understanding of diabetes. The risks to patients' expectation of privacy are great, and their ability to control how their information is collected, stored, and used is virtually nonexistent. Patients' physical security is also at risk if adequate cybersecurity measures are not taken. Currently, data privacy and security protections are not robust enough to address the privacy and security risks and stymies the current and future benefits of CGM and the platforms and apps that communicate with them...
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28236571/multicentre-randomized-controlled-trial-with-sensor-augmented-pump-vs-multiple-daily-injections-in-hospitalized-patients-with-type-2-diabetes-in-china-time-to-reach-target-glucose
#6
W Gu, Y Liu, Y Chen, W Deng, X Ran, L Chen, D Zhu, J Yang, J Shin, S W Lee, T L Cordero, Y Mu
AIM: Sensor-augmented pump (SAP) technology, which combines continuous subcutaneous insulin infusion (CSII) and real-time continuous glucose monitoring (RT-CGM), has been available for several years in China. In this study, the time required to reach predefined glycaemic targets with SAP vs multiple daily injection (MDI) therapy was compared in hospitalized patients with type 2 diabetes mellitus (T2DM). METHODS: Adults (aged 18-65 years) with T2DM treated with insulin and admitted to hospital for glucose management were randomized to either SAP (Medtronic MiniMed™ Paradigm™ 722 system) or MDI with blinded CGM (Medtronic MiniMed CGMS System Gold™) for a 2-week period...
February 21, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28163257/the-relation-of-glycaemic-variability-with-inflammatory-markers-in-obese-children-with-insulin-resistance-and-metabolic-syndrome
#7
Abdurrahman Kaya, Cemil Koçyiğit, Gönül Çatlı, Elif Büşra Özkan, Bumin Nuri Dündar
OBJECTIVE: To investigate the relationship between glycaemic variability and inflammatory parameters in obese children with insulin resistance and to elucidate their effects on the development of metabolic syndrome. METHODS: Fifty obese adolescents with insulin resistance were included in the study. All patients underwent anthropometric measurements, body fat analysis and continuous glucose monitoring system (CGMS) for 24 hours. Serum lipids, adiponectin and interleukin-6 (IL-6) levels were measured...
February 6, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28123707/re-evaluation-of-glycated-hemoglobin-and-glycated-albumin-with-continuous-glucose-monitoring-system-as-markers-of-glycemia-in-patients-with-liver-cirrhosis
#8
Hiroshi Isoda, Hirokazu Takahashi, Yuichiro Eguchi, Motoyasu Kojima, Kanako Inoue, Kenichiro Murayama, Yayoi Matsuda, Keizo Anzai
Liver cirrhosis (LC) is frequently accompanied by glucose intolerance. The present study was designed to determine whether glycated hemoglobin A1c (HbA1c) and glycated albumin (GA) were predictive markers of glycemia, as determined by a continuous glucose monitoring system (CGMS), in patients with LC. A total of 30 patients with LC, including 3, 19, 5, 2 and 1 with LC due to hepatitis B virus, hepatitis C virus, non-alcoholic steatohepatitis, alcohol and unknown causes, respectively, were assessed by CGMS. The average, maximum and minimum blood glucose (BG) levels were measured by CGMS, and correlated with HbA1c and GA...
January 2017: Biomedical Reports
https://www.readbyqxmd.com/read/27977404/sensitivity-and-specificity-of-different-methods-for-cystic-fibrosis-related-diabetes-screening-is-the-oral-glucose-tolerance-test-still-the-standard
#9
Catherine Mainguy, Gabriel Bellon, Véronique Delaup, Tiphanie Ginoux, Behrouz Kassai-Koupai, Stéphane Mazur, Muriel Rabilloud, Laurent Remontet, Philippe Reix
BACKGROUND: Cystic fibrosis-related diabetes (CFRD) is a late cystic fibrosis (CF)-associated comorbidity whose prevalence is increasing sharply lifelong. Guidelines for glucose metabolism (GM) monitoring rely on the oral glucose tolerance test (OGTT). However, this test is neither sensitive nor specific. The aim of this study was to compare sensitivity and specificity of different methods for GM monitoring in children and adolescents with CF. METHODS: Continuous glucose monitoring system (CGMS), used as the reference method, was compared with the OGTT, intravenous glucose tolerance test (IGTT), homeostasis model assessment index of insulin resistance (HOMA-IR), homeostasis model assessment index of β-cell function (HOMA-%B) and glycated haemoglobin A1C...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27899489/diabetes-device-use-in-adults-with-type-1-diabetes-barriers-to-uptake-and-potential-intervention-targets
#10
Molly L Tanenbaum, Sarah J Hanes, Kellee M Miller, Diana Naranjo, Rachel Bensen, Korey K Hood
OBJECTIVE: Diabetes devices (insulin pumps, continuous glucose monitors [CGMs]) are associated with benefits for glycemic control, yet uptake of these devices continues to be low. Some barriers to device uptake may be modifiable through psychosocial intervention, but little is known about which barriers and which patients to target. RESEARCH DESIGN AND METHODS: We surveyed 1,503 adult T1D Exchange participants (mean age 35.3 [SD 14.8] years, mean diagnosis duration 20...
February 2017: Diabetes Care
https://www.readbyqxmd.com/read/27859522/reasoning-with-causal-cycles
#11
Bob Rehder
This article assesses how people reason with categories whose features are related in causal cycles. Whereas models based on causal graphical models (CGMs) have enjoyed success modeling category-based judgments as well as a number of other cognitive phenomena, CGMs are only able to represent causal structures that are acyclic. A number of new formalisms that allow cycles are introduced and evaluated. Dynamic Bayesian networks (DBNs) represent cycles by unfolding them over time. Chain graphs augment CGMs by allowing the presence of undirected links that model feedback relations between variables...
November 17, 2016: Cognitive Science
https://www.readbyqxmd.com/read/27708483/glycated-hemoglobin-hba1c-clinical-applications-of-a-mathematical-concept
#12
Melvin Khee Shing Leow
BACKGROUND AND PURPOSE: Glycated hemoglobin (HbA1c) reflects the cumulative glucose exposure of erythrocytes over a preceding time frame proportional to erythrocyte survival. HbA1c is thus an areal function of the glucose-time curve, an educationally useful concept to aid teaching and clinical judgment. METHODS: An ordinary differential equation is formulated as a parsimonious model of HbA1c. The integrated form yields HbA1c as an area-under-the-curve (AUC) of a glucose-time profile...
July 16, 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/27625296/masked-hypoglycemia-in-pregnancy
#13
Dukhabandhu Naik, Asha Hesarghatta Shyamasunder, Mahesh Doddabelavangala Mruthyunjaya, Rita Gupta Patil, Thomas Vizhalil Paul, Flory Christina, Mercy Inbakumari, Ruby Jose, Jessie Lionel, Annie Regi, P Visalakshi Jeyaseelan, Nihal Thomas
BACKGROUND: Hypoglycemia is a major hindrance for optimal glycemic control in women with gestational diabetes mellitus (GDM) on insulin. In the present study, masked hypoglycemia (glucose <2.77mmol/L for ≥30 min) was estimated in pregnant women using a continuous glucose monitoring (CGM) system. METHODS: Twenty pregnant women with GDM on insulin (cases) and 10 age-matched euglycemic pregnant women (controls) between 24 and 36 weeks gestation were recruited...
September 14, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27552834/prolonged-episodes-of-hypoglycaemia-in-hnf4a-mody-mutation-carriers-with-igt-evidence-of-persistent-hyperinsulinism-into-early-adulthood
#14
S Bacon, M P Kyithar, E M Condron, N Vizzard, M Burke, M M Byrne
AIMS: HNF4A is an established cause of maturity onset diabetes of the young (MODY). Congenital hyperinsulinism can also be associated with mutations in the HNF4A gene. A dual phenotype is observed in HNF4A-MODY with hyperinsulinaemic hypoglycaemia in the neonatal period progressing to diabetes in adulthood. The nature and timing of the transition remain poorly defined. We performed an observational study to establish changes in glycaemia and insulin secretion over a 6-year period. We investigated glycaemic variability and hypoglycaemia in HNF4A-MODY using a continuous glucose monitoring system (CGMS)...
December 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27506420/diabetes-induction-by-total-pancreatectomy-in-minipigs-with-simultaneous-splenectomy-a-feasible-approach-for-advanced-diabetes-research
#15
Sophie Heinke, Barbara Ludwig, Undine Schubert, Janine Schmid, Thomas Kiss, Anja Steffen, Stefan Bornstein, Stefan Ludwig
BACKGROUND: Safe and reliable diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents and also widely used in large animal models of non-human primates and minipigs. However, uncertain efficacy, the potential of beta-cell regeneration, and relevant side effects are debatable aspects particularly in large animals. Therefore, we aimed to evaluate a surgical approach of total pancreatectomy combined with splenectomy for diabetes induction in an exploratory study in Goettingen minipigs...
September 2016: Xenotransplantation
https://www.readbyqxmd.com/read/27498504/biochemical-and-molecular-dissection-of-thermo-sensitive-genetic-male-sterility-in-diploid-cotton-gossypium-arboreum-l
#16
L Sekhar, B M Khadi, Rajesh S Patil, I S Katageri, Ganapati Mukri
Diploid cotton, due to its inherent problem of stamen brittleness, its found unsuitable for traditional method of hybrid seed production which involves hand emasculation followed by pollination. Due to shortfall in other methods viz., Genetic Male Sterility (GMS), as well as, Cytoplasmic Genetic Male Sterility (CGMS), hybrid seed production in diploid cotton becomes costly and thereby, covers less area among the total cotton grown area. Thermo-sensitive genetic male sterility, which overcomes the drawbacks of both GMS and CGMS can be an effective tool in coming years for hybrid cotton research...
July 2016: Journal of Environmental Biology
https://www.readbyqxmd.com/read/27470425/fine-mapping-of-restorer-of-fertility-in-pepper-capsicum-annuum-l-identified-a-candidate-gene-encoding-a-pentatricopeptide-repeat-ppr-containing-protein
#17
Yeong Deuk Jo, Yeaseong Ha, Joung-Ho Lee, Minkyu Park, Alex C Bergsma, Hong-Il Choi, Sandra Goritschnig, Bjorn Kloosterman, Peter J van Dijk, Doil Choi, Byoung-Cheorl Kang
Using fine mapping techniques, the genomic region co-segregating with Restorer - of - fertility ( Rf ) in pepper was delimited to a region of 821 kb in length. A PPR gene in this region, CaPPR6 , was identified as a strong candidate for Rf based on expression pattern and characteristics of encoding sequence. Cytoplasmic-genic male sterility (CGMS) has been used for the efficient production of hybrid seeds in peppers (Capsicum annuum L.). Although the mitochondrial candidate genes that might be responsible for cytoplasmic male sterility (CMS) have been identified, the nuclear Restorer-of-fertility (Rf) gene has not been isolated...
October 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27470137/diurnal-glycemic-fluctuation-is-associated-with-severity-of-coronary-artery-disease-in-prediabetic-patients-possible-role-of-nitrotyrosine-and-glyceraldehyde-derived-advanced-glycation-end-products
#18
Makoto Watanabe, Yasuyuki Kawai, Michihiko Kitayama, Hironubu Akao, Atsushi Motoyama, Minoru Wakasa, Ryuhei Saito, Hirofumi Aoki, Kousuke Fujibayashi, Taketsugu Tsuchiya, Hiroaki Nakanishi, Kazuyuki Saito, Masayoshi Takeuchi, Kouji Kajinami
BACKGROUND: Glucose fluctuation (GF) is a risk factor for coronary artery disease (CAD). However, it remains unknown whether specific indices of GF are risk factors for CAD. Therefore, we evaluated the relationship between GF, as determined by a continuous glucose monitoring system (CGMS) or the glucose level at 2h after a 75-g oral glucose tolerance test (75g OGTT 120), and the severity of CAD in prediabetic patients. We also evaluated whether nitrotyrosine (NT) and glyceraldehyde-derived advanced glycation end-products (Glycer-AGE) were induced by GF...
July 25, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27468313/use-of-a-real-time-continuous-glucose-monitoring-system-as-an-educational-tool-for-patients-with-gestational-diabetes
#19
Eman Alfadhli, Eman Osman, Taghreed Basri
BACKGROUND: Women with gestational diabetes mellitus (GDM) are required to control their blood glucose shortly after GDM diagnosis to minimize adverse pregnancy outcomes. A real time-continuous glucose monitoring system (RT-CGMS) provides the patient with continuous information about the alterations in levels of the blood glucose. This visibility may empower the patient to modify her lifestyle and engage in therapeutic management. The aim of this study was to determine whether a single application of RT-CGMS to pregnant women shortly after GDM diagnosis is useful as an educational and motivational tool...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27463543/effect-of-sensor-location-in-dogs-on-performance-of-an-interstitial-glucose-monitor
#20
Amie Koenig, Margarethe E Hoenig, David A Jimenez
OBJECTIVE To identify variations in glucose values concurrently obtained by use of a continuous glucose monitoring system (CGMS) at the same site, reliability of results for each site, lag time for each site, and influence of site thickness on CGMS accuracy. ANIMALS 8 random-source research dogs. PROCEDURES In experiment 1, 8 CGMS sensors were implanted bilaterally at 1 site (4 sensors/side) in 4 dogs. In experiment 2, 2 CGMS sensors were implanted bilaterally at each of 4 sites (1 sensor/side) in 8 dogs; 4 of those 8 dogs then were subjected to a glycemic clamp technique...
August 2016: American Journal of Veterinary Research
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