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https://www.readbyqxmd.com/read/29137476/acute-glycemic-changes-in-brain-and-subcutaneous-tissue-measured-by-continuous-glucose-monitoring-system-in-hereditary-hypertriglyceridemic-rat
#1
M Žourek, P Kyselová, D Čechurová, Z Rušavý
Parallel glucose measurements in blood and other different tissues give us knowledge about dynamics of glycemia changes, which depend on vascularisation, distribution space and local utilization by tissues. Such information is important for the understanding of glucose homeostasis and regulation. The aim of our study was to determine the time-lag between blood, brain, and adipose tissue during rapid glucose changes in a male hHTG rat (n=15). The CGMS sensor Guardian RT (Minimed/Medtronic, USA) was inserted into the brain and into the abdominal subcutaneous tissue...
November 10, 2017: Physiological Research
https://www.readbyqxmd.com/read/29129244/the-risk-for-hypoglycemia-during-ramadan-fasting-in-patients-with-adrenal-insufficiency
#2
Melika Chihaoui, Wafa Grira, Jihene Bettaieb, Meriem Yazidi, Fatma Chaker, Ons Rejeb, Ibtissem Oueslati, Moncef Feki, Naziha Kaabachi, Hedia Slimane
OBJECTIVES: The risk for hypoglycemia during Ramadan fasting in patients with adrenal insufficiency (AI) is not fully known. The aims of this study were to evaluate this risk objectively and to determine the associated factors. METHODS: This prospective case-crossover study included 25 women and 5 men with known and treated AI and a median age of 38.5 y. Patients underwent clinical examination and a fasting blood sample was collected to measure glucose, urea, creatinine, sodium, potassium, cortisol, growth hormone and free thyroxine...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29106815/high-dose-glucocorticoids-treatment-does-not-induce-severe-hyperglycemia-in-young-patients-with-autoimmune-diseases-by-cgms
#3
Ying Zhou, Yan Zhao, Tao Yuan, Nan Jiang, Yingyue Dong, Yunjiao Yang, Li Wang, Jiuliang Zhao, Le Min, Weigang Zhao
INTRODUCTION: High-dose glucocorticoids (HDG) are used in the treatment of autoimmune diseases. Glucocorticoids-induced hyperglycemia (GIH) is often described in elderly patients. In young patients with autoimmune diseases, however, the risk for GIH has not been well characterized. METHODS: Twenty-four inpatients (median age 32 years (interquatile range 25-42)) with exacerbations of autoimmune diseases, receiving 1-2mg/kg/day prednisone or equivalent methylprednisone, were recruited...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29081069/different-methods-and-settings-for-glucose-monitoring-for-gestational-diabetes-during-pregnancy
#4
REVIEW
Puvaneswary Raman, Emily Shepherd, Therese Dowswell, Philippa Middleton, Caroline A Crowther
BACKGROUND: Incidence of gestational diabetes mellitus (GDM) is increasing worldwide. Blood glucose monitoring plays a crucial part in maintaining glycaemic control in women with GDM and is generally recommended by healthcare professionals. There are several different methods for monitoring blood glucose which can be carried out in different settings (e.g. at home versus in hospital). OBJECTIVES: The objective of this review is to compare the effects of different methods and settings for glucose monitoring for women with GDM on maternal and fetal, neonatal, child and adult outcomes, and use and costs of health care...
October 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29032494/the-effects-of-add-on-exenatide-to-insulin-on-glycemic-variability-and-hypoglycemia-in-patients-with-type-1-diabetes-mellitus
#5
L-L Jiang, S-Q Wang, B Ding, J Zhu, T Jing, L Ye, K-O Lee, J-D Wu, J-H Ma
OBJECTIVE: To investigate the effect of add-on exenatide to insulin on glycemic excursion and the counter-regulatory hormone in response to hypoglycemia in patients with type 1 diabetes mellitus (T1DM). METHODS: 30 patients with T1DM were recruited and randomly assigned to exenatide + insulin-treated group (group 1, n = 15) or insulin-only-treated group (group 2, n = 15) for 4 weeks. All patients had continuous glucose monitor system (CGMS) applied at before (week-0) and after (week-4) treatment to evaluate the glycemic variability...
October 14, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28978579/nocturnal-reactive-hypoglycaemia-well-treated-subjectively-and-objectively-with-voglibose
#6
Hiroyuki Koyama, Hideomi Ohguchi, Takashi Yagi, Kenro Imaeda
Clinicians sometimes encounter difficulty in diagnosing hypoglycaemia. Here, we present a case report of a 53-year-old woman with recurrent nocturnal hypoglycaemia. A continuous glucose monitoring system (CGMS) revealed postprandial hyperglycaemia and subsequent hypoglycaemia, and an oral glucose tolerance test showed an impaired glycaemic and delayed hyperinsulinaemic pattern. On the basis of these clinical findings, we diagnosed her unexplained hypoglycaemia as reactive hypoglycaemia. CGMS showed a sharp contrast of diurnal variation in blood glucose levels including hypoglycaemia between before and after treatment with an alpha-glucosidase inhibitor, voglibose...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28967612/a-history-of-continuous-glucose-monitors-cgms-in-self-monitoring-of-diabetes-mellitus
#7
REVIEW
David Olczuk, Ronny Priefer
Self-monitoring of glucose for individuals afflicted with diabetes mellitus has allowed patients to take control of their disease and thus directly affect the outcomes related to it. It has been almost a century since the first test to monitor one's sugar was developed; that being a urine test. The most well-known and prominent medical device for monitor blood glucose for individuals with diabetes are the finger-prick devices. This itself is an approximately 50year old technology. More recently has been the introduction of continuous glucose monitors (CGMs) which entered the market place in the last year of the 20th century...
September 22, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28898340/-from-insulin-pump-and-continuous-glucose-monitoring-to-the-artificial-pancreas
#8
Pamela Apablaza, Néstor Soto, Ethel Codner
Technology for diabetes care has undergone major development during recent decades. These technological advances include continuous subcutaneous insulin infusion (CSII), also known as insulin pumps, and real-time continuous glucose monitoring system (RT-CGMS). The integration of CSII and RT-CGMS into a single device has led to sensor-augmented pump therapy and more recently, a technology that has automated delivery of basal insulin therapy, known as hybrid system. These new technologies have led to benefits in attaining better metabolic control and decreasing the incidence of severe hypoglycemia, especially in patients with type 1 diabetes...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28860506/differences-in-characteristics-of-glucose-intolerance-between-patients-with-nafld-and-chronic-hepatitis-c-as-determined-by-cgms
#9
Tsunehiro Ochi, Takumi Kawaguchi, Takashi Nakahara, Masafumi Ono, Shuhei Noguchi, Yuichi Koshiyama, Kensuke Munekage, Eisuke Murakami, Akira Hiramatsu, Mitsunari Ogasawara, Akira Hirose, Hiroshi Mizuta, Kosei Masuda, Nobuto Okamoto, Narufumi Suganuma, Kazuaki Chayama, Masahiro Yamaguchi, Takuji Torimura, Toshiji Saibara
Glucose intolerance frequently develops in accordance with the progression of chronic liver disease. However, differences in the characteristics of glucose intolerance between patients with nonalcoholic fatty liver disease (NAFLD) and those with chronic hepatitis C (C-CH) remain incompletely understood. To clarify these differences, patients with NAFLD (n = 37) and C-CH (n = 40) were evaluated with a continuous glucose monitoring system (CGMS). In the patients with NAFLD, Maximum blood glucose concentration and blood glucose swings were significantly correlated with hepatic fibrosis markers...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28643298/a-comparison-of-clinical-efficacy-and-economic-value-in-basalin-and-lantus-treated-patients-with-type-2-diabetes-using-continuous-glucose-monitoring-system
#10
H Q Li, C F Lu, J Wang, G P Yin, R Sun, X H Xu, B L Liu, F F Li, T Jing, K O Lee, L Ye, J H Ma, X F Su
AIM: To determine the clinical non-inferiority of recombinant glargine-Basalin vs glargine-Lantus, in treatment of type 2 diabetes mellitus (T2DM) using continuous glucose monitoring system (CGMS). METHODS: One hundred patients with T2DM were recruited. They were either regularly taking Basalin (Basalin group) or Lantus (Lantus group) (n = 50 each). CGMS was employed to real-time monitor blood glucose profile for 4 days (from day 1 to day 5). To exclude the effect of patient background, the study design was to have a blinded crossover from glargine-Basalin to glargine-Lantus on day 3, and vice versa...
June 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28639756/-value-of-continuous-glucose-monitoring-in-type-2-diabetic-patients
#11
Antonella Corcillo, Sylvie Girardin, Magali Andrey, Olivier Le Dizès, François R Jornayvaz
Management of type 1 and type 2 diabetes mellitus is getting complex with the apparition of new treatments, but also new technologies. Among these, continuous glucose monitoring systems (CGMS) lead to a better glycemic control and less hypoglycemia in type 1 diabetic patients. Studies are scarce in type 2 diabetes but also seem to show a benefit, particularly in patients using insulin. Nevertheless, type 2 diabetic patients taking advantage of CGMS must be better defined. In any case, a multidisciplinary approach to the use of CGMS and interpretation of data is warranted...
May 31, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28604634/modeling-the-error-of-the-medtronic-paradigm-veo-enlite-glucose-sensor
#12
Lyvia Biagi, Charrise M Ramkissoon, Andrea Facchinetti, Yenny Leal, Josep Vehi
Continuous glucose monitors (CGMs) are prone to inaccuracy due to time lags, sensor drift, calibration errors, and measurement noise. The aim of this study is to derive the model of the error of the second generation Medtronic Paradigm Veo Enlite (ENL) sensor and compare it with the Dexcom SEVEN PLUS (7P), G4 PLATINUM (G4P), and advanced G4 for Artificial Pancreas studies (G4AP) systems. An enhanced methodology to a previously employed technique was utilized to dissect the sensor error into several components...
June 12, 2017: Sensors
https://www.readbyqxmd.com/read/28598101/-pancreatic-%C3%AE-cell-functions-measured-by-continuous-glucose-monitoring-in-han-chinese-with-varied-degree-of-glucose-tolerance
#13
Yu Yue, Hua He, Xiao-Jie Yang, Xiagn-Xun Zhang, Da-Wei Chen, Chun Wang, Guan-Jian Liu, Xing-Wu Ran
OBJECTIVES: To compare the pancreatic β-cell functions of Han people between those with normal glucose tolerance (NGT),prediabetes (PD),and newly-diagnosed type 2 diabetes mellitus (NDDM), and to evaluate the value of the continuous glucose monitoring system (CGMS) in determining β-cell functions. METHODS: A total of 169 volunteers of Han people (20-75 years old, 72 male and 97 female) without diagnosed diabetes were given 75-g oral glucose tolerance test (OGTT) and insulin release tests...
September 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28592062/-glucose-excursion-in-senior-patients-with-type-2-diabetes-mellitus-and-coronary-artery-disease
#14
J Liu, F H Liu, Y N Zhao, D E Yan, X Y Gao, L N Wen, J J Wei, S H Su, Y S Zhou
Objectives: To explore glucose excursion and incidence of hypoglycemia in senior patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) with different hemoglobin A1c (HbA1c) values. Methods: Eighty-nine outpatients [58 male, 31 female, aged 69.0 (66.0, 73.0) years] diagnosed with T2DM and CAD in Beijing Anzhen Hospital between June 2013 and March 2016 were divided into group A (HbA1c<6.5%, n=25) and group B (HbA1c≥6.5%, n=64). Every patient wore continuous glucose monitoring system (CGMS) for 72 h...
May 30, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28585876/cgm-pregnancy-and-remote-monitoring
#15
Sarit Polsky, Rachel Garcetti
The glycemic goals of pregnancy are very narrow to reduce excess risks for numerous maternal and fetal complications. Continuous glucose monitors (CGMs) may help women achieve glucose goals and reduce hypoglycemia. CGM use has been found to be safe and effective in pregnancies associated with diabetes. CGM use can accurately identify glycemic patterns among women with and without diabetes in pregnancy. The data on the effects of CGM use on maternal and fetal outcomes are conflicting. Using CGMs in conjunction with continuous subcutaneous insulin infusion therapy in pregnancies complicated by diabetes may improve outcomes...
June 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28584075/application-of-zone-model-predictive-control-artificial-pancreas-during-extended-use-of-infusion-set-and-sensor-a-randomized-crossover-controlled-home-use-trial
#16
Gregory P Forlenza, Sunil Deshpande, Trang T Ly, Daniel P Howsmon, Faye Cameron, Nihat Baysal, Eric Mauritzen, Tatiana Marcal, Lindsey Towers, B Wayne Bequette, Lauren M Huyett, Jordan E Pinsker, Ravi Gondhalekar, Francis J Doyle, David M Maahs, Bruce A Buckingham, Eyal Dassau
OBJECTIVE: As artificial pancreas (AP) becomes standard of care, consideration of extended use of insulin infusion sets (IIS) and continuous glucose monitors (CGMs) becomes vital. We conducted an outpatient randomized crossover study to test the safety and efficacy of a zone model predictive control (zone-MPC)-based AP system versus sensor augmented pump (SAP) therapy in which IIS and CGM failures were provoked via extended wear to 7 and 21 days, respectively. RESEARCH DESIGN AND METHODS: A smartphone-based AP system was used by 19 adults (median age 23 years [IQR 10], mean 8...
August 2017: Diabetes Care
https://www.readbyqxmd.com/read/28560900/effect-of-bgm-accuracy-on-the-clinical-performance-of-cgm-an-in-silico-study
#17
Enrique Campos-Náñez, Marc D Breton
BACKGROUND: Standard management of type 1 diabetes (T1D) relies on blood glucose monitoring based on a range of technologies from self-monitoring of blood glucose (BGM) to continuous glucose monitoring (CGM). Even as CGM technology matures, patients utilize BGM for calibration and dosing. The question of how the accuracy of both technologies interact is still not well understood. METHODS: We use a recently developed data-driven simulation approach to characterize the relationship between CGM and BGM accuracy especially how BGM accuracy impacts CGM performance in four different use cases with increasing levels of reliance on twice daily calibrated CGM...
November 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28541134/clinical-implications-of-accuracy-measurements-of-continuous-glucose-sensors
#18
Timothy S Bailey
The accuracy of a continuous glucose monitor (CGM) now supports its use by persons with diabetes and clinicians caring for them. This article reviews measures of CGM accuracy, factors contributing to accuracy, comparative accuracy assessment, clinical implications of CGM sensor accuracy, and recent clinical trials that have demonstrated the utility of CGMs.
May 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28540756/nonadjunctive-use-of-continuous-glucose-monitors-for-insulin-dosing-is-it-safe
#19
Alan R Shapiro
With the increasing accuracy of continuous glucose monitors (CGM) have come calls for the Food and Drug Administration (FDA) to label these devices as safe for nonadjunctive dosing of insulin. However, there is evidence that these devices are subject to sporadic, unpredictable, large errors. A text analysis of reports to the FDA MAUDE database since 2015 reveals over 25 000 complaints of CGM sensor inaccuracy, with instances directly leading to serious outcomes. These new data were not considered at a recent FDA Advisory Panel meeting that voted to approve Dexcom G5 relabeling for nonadjunctive use...
July 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28464825/continuous-determination-of-blood-glucose-in-children-admitted-with-malaria-in-a-rural-hospital-in-mozambique
#20
Lola Madrid, Antonio Sitoe, Rosauro Varo, Tacilta Nhampossa, Miguel Lanaspa, Abel Nhama, Sozinho Acácio, Isolina Riaño, Aina Casellas, Quique Bassat
BACKGROUND: Hypoglycaemia is a frequent complication among admitted children, particularly in malaria-endemic areas. This study aimed to estimate the occurrence of hypoglycaemia not only upon admission but throughout the first 72 h of hospitalization in children admitted with malaria. METHODS: A simple pilot study to continuously monitor glycaemia in children aged 0-10 years, admitted with malaria in a rural hospital was conducted in Southern Mozambique by inserting continuous glucose monitors (CGMs) in subcutaneous tissue of the abdominal area, producing glycaemia readings every 5 min...
May 2, 2017: Malaria Journal
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