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Diabetes technology

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https://www.readbyqxmd.com/read/28726154/use-of-continuous-glucose-monitoring-in-youth-onset-type-2-diabetes
#1
REVIEW
Christine L Chan
PURPOSE OF REVIEW: Continuous glucose monitoring (CGM) technology has long been accepted as a tool for managing glycemia in type 1 diabetes (T1D) and is receiving increased attention as a tool for monitoring glucose patterns in patients with other forms of diabetes, in particular type 2 diabetes (T2D). Recent studies in adults with T2D have shown benefits of CGM in the investigation of glycemic variability, as well as utility as a tool for improving glycemic control. The literature on CGM use in youth-onset T2D, however, is sparse...
September 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28725914/vascular-complications-in-diabetes-old-messages-new-thoughts
#2
REVIEW
Josephine M Forbes, Amelia K Fotheringham
In parallel with the growing diabetes pandemic, there is an increasing burden of micro- and macrovascular complications, occurring in the majority of patients. The identification of a number of synergistic accelerators of disease, providing therapeutic pathways, has stabilised the incidence of complications in most western nations. However, the primary instigators of diabetic complications and, thus, prevention strategies, remain elusive. This has necessitated a refocus on natural history studies, where tissue and plasma samples are sequentially taken to determine when and how disease initiates...
July 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28724511/apps-for-health-related-education-in-pharmacy-practice-needs-assessment-survey-among-patients-within-a-large-metropolitan-area
#3
Sean M Mirk, Nicole Marie Wegrzyn
BACKGROUND: Patient education resources are crucial to the effectiveness of prescribed pharmacotherapy. However, user interest and patient preference for these materials is lacking. Regardless of the field, nearly every article on designing mHealth apps references the lack of end-user involvement as a key flaw to sustainable design. The traditional paper-based methods of patient education are difficult to tailor to a patient's specific needs and learning styles, but a customizable app might be beneficial...
July 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28724420/legal-access-to-medications-a-threat-to-brazil-s-public-health-system
#4
Ana Luiza Chieffi, Rita De Cassia Barata Barradas, Moisés Golbaum
BACKGROUND: In Brazil, health is fundamental human right guaranteed by the Constitution of 1988, which created the Brazilian Universal Health System (Sistema Único de Saúde - SUS). The SUS provides medications for outpatient care via policy of pharmaceutical assistance (PA) programmes. Despite the advances in PA policies which include the improvement in access to medications, there has been a significant increase in lawsuits related to health products and services. This study aimed to characterize the medication processes filed between 2010 and 2014 against the Secretary of State for Health of São Paulo (State Health Department of São Paulo - SES/SP), in Brazil, following PA policies...
July 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28722418/urine-metabonomics-reveals-early-biomarkers-in-diabetic-cognitive-dysfunction
#5
Lili Song, Pengwei Zhuang, Mengya Lin, Mingqin Kang, Hongyue Liu, Yuping Zhang, Zhen Yang, Yunlong Chen, Yanjun Zhang
Recently, increasing attention has been paid to diabetic encephalopathy which is one of frequent diabetic complications and affects nearly 30% diabetics. Since cognitive dysfunction from diabetic encephalopathy might develop irreversible dementia, early diagnosis and detection of this disease is of great significance for its prevention and treatment. This study is to investigate the early specific metabolites biomarkers in the urine prior to the onset of diabetic cognitive dysfunction (DCD) by using metabolomics technology...
July 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28720429/stable-isotope-based-flux-studies-in-nonalcoholic-fatty-liver-disease
#6
REVIEW
Arthur McCullough, Stephen Previs, Takhar Kasumov
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is associated with the worldwide epidemics of obesity, diabetes and cardiovascular diseases. NAFLD ranges from benign fat accumulation in the liver (steatosis) to non-alcoholic steatohepatitis (NASH), and cirrhosis which can progress to hepatocellular carcinoma and liver failure. Mass spectrometry and magnetic resonance spectroscopy-coupled stable isotope-based flux studies provide new insights into the understanding of NAFLD pathogenesis and the disease progression...
July 15, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28720103/an-information-and-communication-technology-based-centralized-clinical-trial-to-determine-the-efficacy-and-safety-of-insulin-dose-adjustment-education-based-on-a-smartphone-personal-health-record-application-a-randomized-controlled-trial
#7
Gyuri Kim, Ji Cheol Bae, Byoung Kee Yi, Kyu Yeon Hur, Dong Kyung Chang, Moon-Kyu Lee, Jae Hyeon Kim, Sang-Man Jin
BACKGROUND: A Personal Health Record (PHR) is an online application that allows patients to access, manage, and share their health data. PHRs not only enhance shared decision making with healthcare providers, but also enable remote monitoring and at-home-collection of detailed data. The benefits of PHRs can be maximized in insulin dose adjustment for patients starting or intensifying insulin regimens, as frequent self-monitoring of glucose, self-adjustment of insulin dose, and precise at-home data collection during the visit-to-visit period are important for glycemic control...
July 18, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28712822/association-study-of-hnf1a-polymorphisms-with-metabolic-syndrome-in-the-moroccan-population
#8
Imane Morjane, Rym Kefi, Hicham Charoute, Fouzia Lakbakbi El Yaagoubi, Meryem Hechmi, Rachid Saile, Sonia Abdelhak, Abdelhamid Barakat
AIMS: Variants in Hepatocyte Nuclear Factor 1 alpha (HNF1A) gene are associated with Metabolic Syndromeand its components independently. In this study, we aimed to assess the statistical association of the rs1169288, rs2464196 and rs735396 variants and haplotypes of HNF1A gene with metabolic syndrome (MS) and its components in a Moroccan population sample. METHODS: Three variants in the HNF1A gene were genotyped, rs1169288 A>C, rs2464196 G>A and rs735396 T>C in cases and controls from Moroccan population using KASPar(®) technology (KBioscience, UK)...
July 3, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28711971/innovative-technology-shows-impact-of-glycaemic-control-on-peripheral-retinal-vessels-in-adolescents-with-type-1-diabetes
#9
Valli Velayutham, Paul Z Benitez-Aguirre, Maria E Craig, Gerald Liew, Tien Y Wong, Alicia J Jenkins, Kim C Donaghue
AIMS/HYPOTHESIS: Retinal imaging enables non-invasive microvasculature assessment; however, only central retinal vessels have been studied in type 1 diabetes. Peripheral smaller vessels have a major haemodynamic role and may differ from central vessels in their response to the diabetic milieu. We hypothesise that diabetes has a greater impact on peripheral retinal vessels vs central vessels. METHODS: Retinal photographs from adolescents (n = 736; age 12-20 years) with type 1 diabetes were graded (Singapore I Vessel Assessment) with vessel calibres measured in the 'central zone' as central retinal arteriolar and venular equivalents (CRAE and CRVE, respectively) and the 'extended zone' as mean width of arterioles and venules (MWa and MWv, respectively)...
July 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28710094/perspectives-from-the-kidney-health-initiative-on-advancing-technologies-to-facilitate-remote-monitoring-of-patient-self-care-in-rrt
#10
Mitchell H Rosner, Susie Lew, Paul Conway, Jennifer Ehrlich, Robert Jarrin, Uptal D Patel, Karen Rheuban, R Brooks Robey, Neal Sikka, Eric Wallace, Patrick Brophy, James Sloand
Telehealth and remote monitoring of a patient's health status has become more commonplace in the last decade and has been applied to conditions such as heart failure, diabetes mellitus, hypertension, and chronic obstructive pulmonary disease. Conversely, uptake of these technologies to help engender and support home RRTs has lagged. Although studies have looked at the role of telehealth in RRT, they are small and single-centered, and both outcome and cost-effectiveness data are needed to inform future decision making...
July 14, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28702091/educ-dom-comparative-study-of-the-telemonitoring-of-patients-with-type-2-diabetes-versus-standard-monitoring-study-protocol-for-a-randomized-controlled-study
#11
Marie-Christine Turnin, Solène Schirr-Bonnans, Jacques Martini, Jean-Christophe Buisson, Soumia Taoui, Marie-Christine Chauchard, Nadège Costa, Benoît Lepage, Laurent Molinier, Hélène Hanaire
BACKGROUND: The global prevalence of type 2 diabetes is considerable. To avoid or delay its chronic complications, patients with type 2 diabetes should improve blood glucose management by adapting their life style. This involves changing the way in which diabetes is controlled. We believe that, thanks to technological innovations in connected health-monitoring devices, the telemonitoring of type 2 diabetes patients using therapeutic educational tools is likely to help them adapt their treatment and lifestyle habits, and therefore improve blood glucose management...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28701620/comparative-analysis-of-the-intestinal-flora-in-type-2-diabetes-and-nondiabetic-mice
#12
Masanori Horie, Takamasa Miura, Satomi Hirakata, Akira Hosoyama, Sakiko Sugino, Aya Umeno, Kazutoshi Murotomi, Yasukazu Yoshida, Taisuke Koike
A relationship between type 2 diabetes mellitus (T2DM) and intestinal flora has been suggested since development of analysis technology for intestinal flora. An animal model of T2DM is important for investigation of T2DM. Although there are some animal models of T2DM, a comparison of the intestinal flora of healthy animals with that of T2DM animals has not yet been reported. The intestinal flora of Tsumura Suzuki Obese Diabetes (TSOD) mice was compared with that of Tsumura, Suzuki, Non Obesity (TSNO) mice in the present study...
July 12, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28698167/use-of-a-connected-glucose-meter-and-certified-diabetes-educator-coaching-to-decrease-the-likelihood-of-abnormal-blood-glucose-excursions-the-livongo-for-diabetes-program
#13
Janelle Downing, Jenna Bollyky, Jennifer Schneider
BACKGROUND: The Livongo for Diabetes Program offers members (1) a cellular technology-enabled, two-way messaging device that measures blood glucose (BG), centrally stores the glucose data, and delivers messages back to the individual in real time; (2) unlimited BG test strips; and (3) access to a diabetes coaching team for questions, goal setting, and automated support for abnormal glucose excursions. The program is sponsored by at-risk self-insured employers, health plans and provider organizations where it is free to members with diabetes or it is available directly to the person with diabetes where they cover the cost...
July 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28692442/current-issues-in-allogeneic-islet-transplantation
#14
Charles A Chang, Michael C Lawrence, Bashoo Naziruddin
PURPOSE OF REVIEW: Transplantation of allogenic pancreatic islets is a minimally invasive treatment option to control severe hypoglycemia and dependence on exogenous insulin among type 1 diabetes (T1D) patients. This overview summarizes the current issues and progress in islet transplantation outcomes and research. RECENT FINDINGS: Several clinical trials from North America and other countries have documented the safety and efficacy of clinical islet transplantation for T1D patients with impaired hypoglycemia awareness...
July 7, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28690856/it-supported-integrated-care-pathways-for-diabetes-a-compilation-and-review-of-good-practices
#15
Hubertus Jm Vrijhoef, Antonio Giulio de Belvis, Matias de la Calle, Maria Stella de Sabata, Bastian Hauck, Sabrina Montante, Annette Moritz, Dario Pelizzola, Markku Saraheimo, Nick A Guldemond
INTRODUCTION: Integrated Care Pathways (ICPs) are a method for the mutual decision-making and organization of care for a well-defined group of patients during a well-defined period. The aim of a care pathway is to enhance the quality of care by improving patient outcomes, promoting patient safety, increasing patient satisfaction, and optimizing the use of resources. To describe this concept, different names are used, e.g. care pathways and integrated care pathways. Modern information technologies (IT) can support ICPs by enabling patient empowerment, better management, and the monitoring of care provided by multidisciplinary teams...
June 2017: International Journal of Care Coordination
https://www.readbyqxmd.com/read/28690099/electrospun-polymeric-nanofibers-new-horizons-in-drug-delivery
#16
REVIEW
Shreya Thakkar, Manju Misra
Nanofibers obtained using electrospinning technique are being used since ages especially in fields of textile industry, sensors, filters, protective clothing and tissue engineering. Their use as drug delivery system is an emerging platform in the field of pharmaceuticals and now-a-days formulation scientists are paying great attention to the technology due to several advantages prime being easy modulation of drug release profile depending upon the properties of polymer/polymeric blends/other materials used...
July 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28688716/exercise-induced-glut4-transcription-via-inactivation-of-hdac4-5-in-mouse-skeletal-muscle-in-an-ampk%C3%AE-2-dependent-manner
#17
Yanmei Niu, Tianyi Wang, Sujuan Liu, Hairui Yuan, Huige Li, Li Fu
Abnormal glucose metabolism induces various metabolic disorders such as insulin resistance and type 2 diabetes. Regular exercise improved glucose uptake and enhanced glucose oxidation by increasing GLUT4 transcription in skeletal muscle. However, the regulatory mechanisms of GLUT4 transcription in response to exercise are poorly understood. AMPK is a sensor of exercise and upstream kinase of class II HDACs that act as transcriptional repressors. We used 6-week treadmill exercise or one single-bout exercise wild type or AMPKα2(-/-) C57BL/6J mice to explore how HDACs regulate GLUT4 transcription and the underlying molecular mechanisms mediated by AMPK in the physiologic process of exercise...
July 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28688267/factors-affecting-lumbar-surgery-outcome-a-nation-wide-population-based-retrospective-study
#18
Vincent Chin-Hung Chen, Yao-Hsu Yang, Pin-Yuan Chen, Jen-Tsung Yang, Carl P C Chen, Chi-Jen Chen, Mong Liang Lu, Yena Lee, Roger S McIntyre, Yin-Cheng Huang
BACKGROUND: Lower back pain is a very common symptom and treatment strategies vary according the severity and duration of illness. Surgical approaches are becoming increasingly popular with the advent of new and less invasive technologies; however, treatment outcomes are not yet well established on a population-based level. Taiwan's National Health Insurance Research Database (NHIRD) is longitudinal and includes 98% of the population since its inception in 1995. The database includes the ICD 9...
June 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28687554/innovative-models-for-providing-clinical-pharmacy-services-to-remote-locations-using-clinical-video-telehealth
#19
Cassie Perdew, Katie Erickson, Jessica Litke
PURPOSE: The use of videoconferencing and other telehealth technologies to expand access to clinical pharmacy services at multiple Veterans Affairs (VA) clinics in rural areas of Alaska and the northwestern United States is described. SUMMARY: Beginning in 2014, clinical pharmacy specialists at a regional VA Telehealth Hub based at Boise VA Medical Center in Idaho have provided telehealth services for 16 clinics. In one telehealth model, a pharmacist and other remotely located primary care team members (a medical provider, a medical support assistant, a social worker, and a psychologist) conduct telehealth visits with veterans located at VA clinics, with support provided by clinic-based nursing staff; this model has been used to improve medication management services for veterans in sparsely populated areas...
July 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28686045/challenges-of-diabetes-management-in-toddlers
#20
Asma Deeb
Toddlers with type 1 diabetes have distinctive combination of challenges to their families and healthcare providers. A major factor is the difficulty in achieving metabolic control without risking hypoglycemia. The rising incidence of type 1 diabetes in toddlers increases the magnitude of the problem and creates a greater need for providing specialized service to cater for this age group's unique need. Type 1 has a specific disease nature in younger children and its clinical presentation mimics common childhood diseases...
July 7, 2017: Diabetes Technology & Therapeutics
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