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Diabetes technology

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https://www.readbyqxmd.com/read/29334198/enzyme-based-glucose-sensor-from-invasive-to-wearable-device
#1
REVIEW
Hyunjae Lee, Yongseok Joseph Hong, Seungmin Baik, Taeghwan Hyeon, Dae-Hyeong Kim
Blood glucose concentration is a key indicator of patients' health, particularly for symptoms associated with diabetes mellitus. Because of the large number of diabetic patients, many approaches for glucose measurement have been studied to enable continuous and accurate glucose level monitoring. Among them, electrochemical analysis is prominent because it is simple and quantitative. This technology has been incorporated into commercialized and research-level devices from simple test strips to wearable devices and implantable systems...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29331301/marrow-adipose-tissue-imaging-in-humans
#2
Vibha Singhal, Miriam A Bredella
Bone strength is affected not only by bone mineral density (BMD) and bone microarchitecture but also its microenvironment. Recent studies have focused on the role of marrow adipose tissue (MAT) in the pathogenesis of bone loss. Osteoblasts and adipocytes arise from a common mesenchymal stem cell within bone marrow and many osteoporotic states, including aging, medication use, immobility, over - and undernutrition are associated with increased marrow adiposity. Advancements in imaging technology allow the non-invasive quantification of MAT...
January 10, 2018: Bone
https://www.readbyqxmd.com/read/29329023/women-s-experiences-with-using-a-smartphone-app-the-pregnant-app-to-manage-gestational-diabetes-mellitus-in-a-randomised-controlled-trial
#3
Jeanette B Skar, Lisa M Garnweidner-Holme, Mirjam Lukasse, Laura Terragni
OBJECTIVE: The purpose of this study was to explore the experiences of women with gestational diabetes mellitus (GDM) with controlling their blood glucose values and receiving health and nutrition information using a smartphone app (the Pregnant+ app). DESIGN AND PARTICIPANTS: The study utilised the interpretative phenomenological analysis method. Semi-structured interviews were conducted with 17 participants among those participating to the randomised controlled trial...
December 27, 2017: Midwifery
https://www.readbyqxmd.com/read/29325019/deep-molecular-phenotypes-link-complex-disorders-and-physiological-insult-to-cpg-methylation
#4
Shaza B Zaghlool, Dennis O Mook-Kanamori, Sara Kader, Nisha Stephan, Anna Halama, Rudolf Engelke, Hina Sarwath, Eman K Al-Dous, Yasmin A Mohamoud, Werner Roemisch-Margl, Jerzy Adamski, Gabi Kastenmüller, Nele Friedrich, Alessia Visconti, Pei-Chien Tsai, Tim Spector, Jordana Bell, Mario Falchi, Annika Wahl, Melanie Waldenberger, Annette Peters, Christian Gieger, Maija Pezer, Gordan Lauc, Johannes Graumann, Joel A Malek, Karsten Suhre
Epigenetic regulation of cellular function provides a mechanism for rapid organismal adaptation to changes in health, lifestyle, and environment. Associations of cytosine-guanine di-nucleotide (CpG) methylation with clinical endpoints that overlap with metabolic phenotypes suggest a regulatory role for these CpG sites in the body's response to disease or environmental stress. We previously identified 20 CpG sites in an epigenome-wide association study (EWAS) with metabolomics that were also associated in recent EWASs with diabetes-, obesity-, and smoking-related endpoints...
January 8, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29320885/a-pilot-study-validating-select-research-grade-and-consumer-based-wearables-throughout-a-range-of-dynamic-exercise-intensities-in-persons-with-and-without-type-1-diabetes-a-novel-approach
#5
Loren Yavelberg, Dessi Zaharieva, Ali Cinar, Michael C Riddell, Veronica Jamnik
BACKGROUND: The increasing popularity of wearable technology necessitates the evaluation of their accuracy to differentiate physical activity (PA) intensities. These devices may play an integral role in customizing PA interventions for primary prevention and secondary management of chronic diseases. For example, in persons with type 1 diabetes (T1D), PA greatly affects glucose concentrations depending on the intensity, mode (ie, aerobic, anaerobic, mixed), and duration. This variability in glucose responses underscores the importance of implementing dependable wearable technology in emerging avenues such as artificial pancreas systems...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29317927/pharmacists-providing-care-in-the-outpatient-setting-through-telemedicine-models-a-narrative-review
#6
Sydney L Littauer, Dave L Dixon, Vimal K Mishra, Evan M Sisson, Teresa M Salgado
Telemedicine refers to the delivery of clinical services using technology that allows two-way, real time, interactive communication between the patient and the clinician at a distant site. Commonly, telemedicine is used to improve access to general and specialty care for patients in rural areas. This review aims to provide an overview of existing telemedicine models involving the delivery of care by pharmacists via telemedicine (including telemonitoring and video, but excluding follow-up telephone calls) and to highlight the main areas of chronic-disease management where these models have been applied...
October 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/29317385/development-and-evaluation-of-a-mobile-personalized-blood-glucose-prediction-system-for-patients-with-gestational-diabetes-mellitus
#7
Evgenii Pustozerov, Polina Popova, Aleksandra Tkachuk, Yana Bolotko, Zafar Yuldashev, Elena Grineva
BACKGROUND: Personalized blood glucose (BG) prediction for diabetes patients is an important goal that is pursued by many researchers worldwide. Despite many proposals, only a few projects are dedicated to the development of complete recommender system infrastructures that incorporate BG prediction algorithms for diabetes patients. The development and implementation of such a system aided by mobile technology is of particular interest to patients with gestational diabetes mellitus (GDM), especially considering the significant importance of quickly achieving adequate BG control for these patients in a short period (ie, during pregnancy) and a typically higher acceptance rate for mobile health (mHealth) solutions for short- to midterm usage...
January 9, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29316905/app-technology-to-increase-physical-activity-among-patients-with-diabetes-type-2-the-diacert-study-a-randomized-controlled-trial
#8
Stephanie E Bonn, Christina Alexandrou, Kristin Hjörleifsdottir Steiner, Klara Wiklander, Claes-Göran Östenson, Marie Löf, Ylva Trolle Lagerros
BACKGROUND: Physical activity can decrease the risk of complications related to diabetes type 2. Feasible and scalable strategies to implement support for a healthy lifestyle for patients in primary care are needed. The aim of the DiaCert-study is to evaluate a digital healthcare platform and the effect of a 12-week long smartphone-app physical activity intervention aiming at increasing physical activity (primary outcome) and improve levels of HbA1c (glycated hemoglobin), blood lipids, blood pressure, body composition, as well as other lifestyle factors and overall health in patients with diabetes type 2...
January 10, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29316609/development-of-a-communication-strategy-to-increase-interprofessional-collaboration-in-the-outpatient-setting
#9
Chelsea Phillips Renfro, Stefanie Ferreri, Tiffany Graham Barber, Stephanie Foley
Managing patient health is a complex task, requiring the support of an interprofessional healthcare team. Collaboration between neighboring community pharmacies and primary care practices can be an alternate solution for team-based patient care. The purpose of this project was to design and implement a communication strategy for patients with diabetes and hypertension between a community pharmacy and physician practice. An interprofessional team for the practice settings was formed to develop a strategy for collaboration...
January 6, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29316320/human-microbiota-blood-group-antigens-and-disease
#10
REVIEW
D Rose Ewald, Susan C J Sumner
Far from being just "bugs in our guts," the microbiota interacts with the body in previously unimagined ways. Research into the genome and the microbiome has revealed that the human body and the microbiota have a long-established but only recently recognized symbiotic relationship; homeostatic balance between them regulates body function. That balance is fragile, easily disturbed, and plays a fundamental role in human health-our very survival depends on the healthy functioning of these microorganisms. Increasing rates of cardiovascular, autoimmune, and inflammatory diseases, as well as epidemics in obesity and diabetes in recent decades are believed to be explained, in part, by unintended effects on the microbiota from vaccinations, poor diets, environmental chemicals, indiscriminate antibiotic use, and "germophobia...
January 9, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29314827/macrophage-specific-in-vivo-gene-editing-using-cationic-lipid-assisted-polymeric-nanoparticles
#11
Ying-Li Luo, Cong-Fei Xu, Hong-Jun Li, Zhi-Ting Cao, Jing Liu, Ji-Long Wang, Xiao-Jiao Du, Xian-Zhu Yang, Zhen Gu, Jun Wang
The CRISPR/Cas9 gene editing technology holds promise for the treatment of multiple diseases. However, the inability to perform specific gene editing in targeted tissues and cells, which may cause off-target effects, is one of the critical bottlenecks for therapeutic application of CRISPR/Cas9. Herein, macrophage-specific promoter-driven Cas9 expression plasmids (pM458 and pM330) were constructed and encapsulated in cationic lipid-assisted PEG-b-PLGA nanoparticles (CLAN). The obtained nanoparticles encapsulating the CRISPR/Cas9 plasmids were able to specifically express Cas9 in macrophages as well as their precursor monocytes both in vitro and in vivo...
January 9, 2018: ACS Nano
https://www.readbyqxmd.com/read/29310448/motivations-for-participation-in-an-online-social-media-community-for-diabetes
#12
Katherine White, Achamyeleh Gebremariam, Dana Lewis, Weston Nordgren, James Wedding, Josh Pasek, Ashley Garrity, Emily Hirschfeld, Joyce M Lee
BACKGROUND: Our objectives were to describe individuals' motivations for participation in an online social media community and to assess their level of trust in medical information provided by medical professionals and community members. METHODS: A purposive survey was delivered to participants recruited through posts on the CGM in the Cloud group, Twitter, and blogs. Individuals were asked a series of demographic and social media use questions. RESULTS: A total of 1268 members of the CGM in the Cloud community responded to the survey...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29304148/the-effectiveness-of-smoking-cessation-physical-activity-diet-and-alcohol-reduction-interventions-delivered-by-mobile-phones-for-the-prevention-of-non-communicable-diseases-a-systematic-review-of-randomised-controlled-trials
#13
Melissa Palmer, Jennifer Sutherland, Sharmani Barnard, Aileen Wynne, Emma Rezel, Andrew Doel, Lily Grigsby-Duffy, Suzanne Edwards, Sophie Russell, Ellie Hotopf, Pablo Perel, Caroline Free
BACKGROUND: We conducted a systematic review to assess the effectiveness of smoking cessation, physical activity (PA), diet, and alcohol reduction interventions delivered by mobile technology to prevent non-communicable diseases (NCDs). METHODS: We searched for randomised controlled trials (RCTs) of mobile-based NCD prevention interventions using MEDLINE, EMBASE, Global Health, CINAHL (Jan 1990-Jan 2016). Two authors extracted data. FINDINGS: 71 trials were included: smoking cessation (n = 18); PA (n = 15), diet (n = 3), PA and diet (n = 25); PA, diet, and smoking cessation (n = 2); and harmful alcohol consumption (n = 8)...
2018: PloS One
https://www.readbyqxmd.com/read/29291433/the-electrochemical-behavior-of-a-fad-dependent-glucose-dehydrogenase-with-direct-electron-transfer-subunit-by-immobilization-on-self-assembled-monolayers
#14
Inyoung Lee, Noya Loew, Wakako Tsugawa, Chi-En Lin, David Probst, Jeffrey T La Belle, Koji Sode
Continuous glucose monitoring (CGM) is a vital technology for diabetes patients by providing tight glycemic control. Currently, many commercially available CGM sensors use glucose oxidase (GOD) as sensor element, but this enzyme is not able to transfer electrons directly to the electrode without oxygen or an electronic mediator. We previously reported a mutated FAD dependent glucose dehydrogenase complex (FADGDH) capable of direct electron transfer (DET) via an electron transfer subunit without involving oxygen or a mediator...
December 20, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29291410/effect-of-frozen-thawed-embryo-transfer-on-birthweight-macrosomia-and-low-birthweight-rates-in-us-singleton-infants
#15
Julia F Litzky, Sheree L Boulet, Navid Esfandiari, Yujia Zhang, Dmitry M Kissin, Regan N Theiler, Carmen J Marsit
BACKGROUND: Singleton infants conceived using assisted reproductive technology have lower average birthweights than naturally-conceived infants and are more likely to be born low birthweight (<2500 grams). Lower birthweights are associated with increased infant and child mortality and poor adult health outcomes, including cardiovascular disease, hypertension, and diabetes. Data from registry and single center studies suggest that frozen/thawed embryo transfer may be associated with larger birthweights...
December 29, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29288733/ophthalmic-gels-past-present-and-future
#16
Ali A Al-Kinani, Ghada Zidan, Naba Elsaid, Ali Seyfoddin, Adam W G Alani, Raid G Alany
Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract increasing interest for various eye health-related applications. They allow the incorporation of a variety of ophthalmic pharmaceuticals to achieve sustained and therapeutic levels of drugs and bioactives at target ocular sites. The integration of sophisticated drug delivery technologies such as nanotechnology-based, intelligent and environment responsive systems can extend current treatment duration to provide more clinically relevant time courses (weeks and months instead of hours and days) which will inevitably reduce dose frequency, increase patient compliance and improve clinical outcomes...
December 27, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29286049/technology-watch-ai-can-diagnose-diabetic-retinopathy
#17
Alan Morris
No abstract text is available yet for this article.
December 22, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29279252/automated-blood-glucose-control-in-type-1-diabetes-a-review-of-progress-and-challenges
#18
Arthur Bertachi, Charrise M Ramkissoon, Jorge Bondia, Josep Vehí
Since the 2000s, research teams worldwide have been working to develop closed-loop (CL) systems able to automatically control blood glucose (BG) levels in patients with type 1 diabetes. This emerging technology is known as artificial pancreas (AP), and its first commercial version just arrived in the market. The main objective of this paper is to present an extensive review of the clinical trials conducted since 2011, which tested various implementations of the AP for different durations under varying conditions...
December 24, 2017: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29278712/a-national-survey-on-the-efficacy-and-safety-of-continuous-subcutaneous-insulin-infusion-in-patients-with-type-1-diabetes-in-spain
#19
P Beato-Víbora, Ana Chico-Ballesteros, Marga Giménez, Raquel Guerrero-Vázquez, Raquel Barrio-Castellanos, María José Goñi-Iriarte, Gonzalo Díaz-Soto, Juan Francisco Merino-Torres, Jesús Moreno-Fernández, María Asunción Martínez-Brocca
AIMS: To assess safety and benefits of continuous subcutaneous insulin infusion (CSII) therapy in a cohort of type 1 diabetes patients in Spain. METHODS: A web-based national registry was created by the Working Group of the Spanish Diabetes Association. All patients on CSII being followed at selected referral centers were included. A cross-sectional analysis was performed. RESULTS: A total of 1,275 patients were included. Data completion for patients on CSII was 67 ± 32%...
December 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29278370/a-component-based-approach-for-securing-indoor-home-care-applications
#20
Aitor Agirre, Aintzane Armentia, Elisabet Estévez, Marga Marcos
eHealth systems have adopted recent advances on sensing technologies together with advances in information and communication technologies (ICT) in order to provide people-centered services that improve the quality of life of an increasingly elderly population. As these eHealth services are founded on the acquisition and processing of sensitive data (e.g., personal details, diagnosis, treatments and medical history), any security threat would damage the public's confidence in them. This paper proposes a solution for the design and runtime management of indoor eHealth applications with security requirements...
December 26, 2017: Sensors
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