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JOURNAL ARTICLE
Taylor M Mobley, Eleanor Hayes-Larson, Yingyan Wu, Rachel L Peterson, Kristen M George, Paola Gilsanz, M Maria Glymour, Marilyn D Thomas, Lisa L Barnes, Rachel A Whitmer, Elizabeth Rose Mayeda
For Black students in the United States, attending schools with a higher proportion of White students is associated with worse mental and physical health outcomes in adolescence/early adulthood. No prior studies evaluate K-12 school racial composition and later-life mental health. In a cohort of Black adults ages 50+ in Northern California who retrospectively self-reported school racial composition for grades 1, 6, 9, and 12, we assessed the association between attending a school with mostly Black students vs...
April 17, 2024: American Journal of Epidemiology
#22
JOURNAL ARTICLE
Junwei Wang, Aiwei Zhang, Cunming Zhang, Miaoyong Ye
BACKGROUND: The relationship between waist circumference and nocturia has not been previously studied. This study investigated the association between waist circumference and the occurrence of nocturia in adults. METHODS: We analyzed data from the National Health and Nutrition Examination Survey covering 2005-2020, encompassing 6287 adults aged ≥20. Nocturia was defined as the need to urinate two or more times during the night. First, we compared baseline characteristics between the nocturia and non-nocturia groups...
April 18, 2024: Neurourology and Urodynamics
#23
JOURNAL ARTICLE
Wenjing Zhang, Laixiang Wang, Bo Hu, Mengmeng Jin, Jinxing Zhou
To observe developmental changes in the ovarian tissue structure and distribution characteristics of oestrogen receptors (ERs) in the ovaries of Huanghuai goats at different ages, we selected healthy Huanghuai goats ewes and divided them into five groups (i.e. 3-, 30-, 60-, 90- and 120-day-old groups), with 10 animals in each group. The serum was separated after blood collection through the jugular vein, and the contents of oestrogen (E) and progesterone (P) in the serum of Huanghuai goats at each age were determined...
May 2024: Anatomia, Histologia, Embryologia
#24
JOURNAL ARTICLE
Niccolo' Tesi, Sven van der Lee, Marc Hulsman, Natasja M van Schoor, Martijn Huisman, Yolande Pijnenburg, Wiesje M van der Flier, Marcel Reinders, Henne Holstege
BACKGROUND: Alzheimer's disease (AD) prevalence increases with age, yet a small fraction of the population reaches ages > 100 years without cognitive decline. We studied the genetic factors associated with such resilience against AD. METHODS: Genome-wide association studies identified 86 single nucleotide polymorphisms (SNPs) associated with AD risk. We estimated SNP frequency in 2281 AD cases, 3165 age-matched controls, and 346 cognitively healthy centenarians...
April 18, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#25
JOURNAL ARTICLE
Sara Mazzucco, Linxin Li, Maria Assuncao Tuna, Peter M Rothwell
INTRODUCTION: Cerebral blood flow (CBF) declines with age and abnormalities in CBF are associated with age-related cerebrovascular disease and neurodegeneration. Women have higher CBF than men, although this sex-difference diminishes to some extent with age in healthy subjects. The physiological drivers of these age/sex differences are uncertain, but might be secondary to age and sex-differences in haemoglobin (Hb) level. Hb levels are inversely correlated with CBF, are lower in women, and decline with age in men, but the interrelations between these factors have not been explored systematically either in healthy subjects or across the full age-range in patients with vascular risk factors...
April 18, 2024: European Stroke Journal
#26
JOURNAL ARTICLE
Julian Macoveanu, Lydia Fortea, Hanne Lie Kjærstad, Klara Coello, Maria Faurholt-Jepsen, Patrick M Fisher, Gitte Moos Knudsen, Joaquim Radua, Eduard Vieta, Sophia Frangou, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak
BACKGROUND: There is a significant contribution of genetic factors to the etiology of bipolar disorder (BD). Unaffected first-degree relatives of patients (UR) with BD are at increased risk of developing mental disorders and may manifest cognitive impairments and alterations in brain functional and connective dynamics, akin to their affected relatives. METHODS: In this prospective longitudinal study, resting-state functional connectivity was used to explore stable and progressive markers of vulnerability i...
April 18, 2024: Psychological Medicine
#27
JOURNAL ARTICLE
Rabeea Maqsood, Susie Schofield, Alexander N Bennett, Ahmed Khattab, Anthony M J Bull, Nicola T Fear, Christopher J Boos
BACKGROUND: Respiration is a crucial determinant of autonomic balance and heart rate variability (HRV). The comparative effect of spontaneous versus paced breathing on HRV has been almost exclusively explored in healthy adults and never been investigated in an injured military cohort. OBJECTIVE: To examine the effect of spontaneous versus paced breathing on HRV in veterans with combat-related traumatic injury (CRTI). DESIGN: Observational cohort study...
April 18, 2024: PM & R: the Journal of Injury, Function, and Rehabilitation
#28
JOURNAL ARTICLE
Atsuo Kondo, Osamu Kamihira, Tomonori Itoh, Momokazu Gotoh, Kumiko Kato
OBJECTIVES: This study evaluated patients with occult spinal dysraphism who underwent spinal cord untethering. METHODS: Twenty-four patients who visited us between 1983 and 2000 were followed-up for a mean duration of 31 years. We studied their lower urinary tract function, skin stigmata, fertility, and work participation. RESULTS: Questionnaires sent in 2022 revealed that 5 patients had normal voiding (Group A) and 19 patients had abnormal voiding (Group B)...
April 18, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
#29
JOURNAL ARTICLE
Andrew Keith Wills, Elisabet Rudjord Hillesund, Wendy Van Lippevelde, Mary Barker, Frøydis Nordgård Vik, Nina Cecilie Øverby
Our aim was to estimate associations of adolescent dietary patterns and meal habits with hypertensive disorders of pregnancy (HDP) and preterm birth. We used data from a prospective cohort study (Norwegian Young-HUNT1) where dietary information was collected during adolescence and pregnancy outcomes were obtained through record linkage to the Norwegian national birth registry. The outcomes were HDP, hypertension, preeclampsia/ eclampsia, and preterm birth in the first pregnancy and in any pregnancy. Diet was self-reported from validated questionnaires and exposures were dietary indexes (healthy; unhealthy; fruit and vegetable; fibre index) and meal habits...
April 18, 2024: British Journal of Nutrition
#30
JOURNAL ARTICLE
Giulia Rapezzano, Marco Marcatili, Richard Stephenson, Regina Pereira, Gayle Hallowell, Marco Duz
BACKGROUND: Peritoneal fluid lactate concentration is an important diagnostic tool in horses with abdominal pain. Information on peritoneal lactate concentrations is lacking following parturition in the mare. OBJECTIVES: To compare blood and peritoneal lactate concentrations in a population of mares within 36 h post-partum, report a normal reference range and identify any impact of retained foetal membranes (RFMs). METHODS: This is a retrospective study evaluating healthy mares from which blood and peritoneal samples had been obtained within 36 h of parturition...
May 2024: Veterinary Medicine and Science
#31
JOURNAL ARTICLE
Mildred Min, Silvia H Pérez Damonte, Raja K Sivamani
BACKGROUND: Skin photoaging and uneven pigmentation are common dermatological concerns. Tetrahexyldecyl ascorbate (THDA) and acetyl zingerone (AZ) are potent antioxidants that have been shown to have anti-photoaging and anti-pigmentation effects. THDA is a more stable and penetrable form of vitamin C. AZ is an antioxidant derived from ginger which has clinical evidence for improving photoaging. However, no studies have assessed how they may synergistically act on the skin. AIMS: This study aims to assess whether a serum containing both THDA and AZ can improve photoaging and the appearance of uneven facial pigmentation...
April 17, 2024: Journal of Cosmetic Dermatology
#32
JOURNAL ARTICLE
Qingwei Zheng, Feijie Wang, Chenzhipeng Nie, Kuiliang Zhang, Yujie Sun, Waleed Al-Ansi, Qiming Wu, Li Wang, Jun Du, Yan Li
Mitochondrial dysfunction increasingly becomes a target for promoting healthy aging and longevity. The dysfunction of mitochondria with age ultimately leads to a decline in physical functions. Among them, biogenesis dysfunction and the imbalances in the metabolism of reactive oxygen species and mitochondria as signaling organelles in the aging process have aroused our attention. Dietary intervention in mitochondrial dysfunction and physical decline during aging processes is essential, and greater attention should be directed toward healthful legume intake...
May 2024: Comprehensive Reviews in Food Science and Food Safety
#33
JOURNAL ARTICLE
Janice K Louie, Rocio Agraz-Lara, Gustavo E Velásquez, Allison Phillips, John D Szumowski
BACKGROUND: A multicountry randomized controlled trial has demonstrated that pan-susceptible pulmonary tuberculosis (TB) can be successfully treated with a 4-month regimen of daily isoniazid, rifapentine, moxifloxacin, and pyrazinamide (HPMZ). We piloted HPMZ in San Francisco (SF) using a modified version of the US Centers for Disease Control and Prevention HPMZ treatment guidelines. METHODS: In this retrospective cohort, patients consecutively referred to SF TB clinic were evaluated for HPMZ eligibility based on preestablished inclusion/exclusion criteria...
April 2024: Open Forum Infectious Diseases
#34
JOURNAL ARTICLE
Pauline Hotterbeex, Melanie Beeckman, Pieter-Jan Marent, Julie Latomme, Fien De Block, Lauren De Baets, Sebastien Chastin, Greet Cardon, Jannique G Z van Uffelen
Given the aging population, finding solutions to retain optimal cognitive capacity is a research priority. The potential of physical activity to reduce the risk of cognitive decline and to enhance cognitive functioning is established. Combining physical with cognitive activity has been put forward as a potentially even more effective way to promote healthy cognitive aging. Most studies on combined interventions have however been conducted in laboratory settings. This paper reports on a two-phased pilot study evaluating the acceptability and feasibility of a newly developed real-life cognitively enriched walking program for adults aged 65+ years...
2024: Journal of Aging Research
#35
JOURNAL ARTICLE
Hille J Torenvlied, Evelien Trip, Wouter Olthuis, Loes I Segerink, Jack J H Beck
OBJECTIVE: The objective of this study is to assess the impact of overnight environmental conditions on erectile penile temperature within a controlled setting, with the aim of investigating the feasibility of using temperature measurements for nocturnal erection detection in erectile dysfunction diagnostics. SUBJECTS/PATIENTS AND METHODS: We conducted a proof-of-concept study involving 10 healthy male participants aged 20 to 25. The study was carried out at the Department of Urology, St...
April 2024: BJUI compass
#36
Marijne Vandebergh, Eliana Marisa Ramos, Nick Corriveau-Lecavalier, Vijay K Ramanan, John Kornak, Carly Mester, Tyler Kolander, Danielle Brushaber, Adam M Staffaroni, Daniel Geschwind, Amy Wolf, Kejal Kantarci, Tania F Gendron, Leonard Petrucelli, Marleen Van den Broeck, Sarah Wynants, Matthew C Baker, Sergi Borrego-Écija, Brian Appleby, Sami Barmada, Andrea Bozoki, David Clark, R Ryan Darby, Bradford C Dickerson, Kimiko Domoto-Reilly, Julie A Fields, Douglas R Galasko, Nupur Ghoshal, Neill Graff-Radford, Ian M Grant, Lawrence S Honig, Ging-Yuek Robin Hsiung, Edward D Huey, David Irwin, David S Knopman, Justin Y Kwan, Gabriel C Léger, Irene Litvan, Joseph C Masdeu, Mario F Mendez, Chiadi Onyike, Belen Pascual, Peter Pressman, Aaron Ritter, Erik D Roberson, Allison Snyder, Anna Campbell Sullivan, M Carmela Tartaglia, Dylan Wint, Hilary W Heuer, Leah K Forsberg, Adam L Boxer, Howard J Rosen, Bradley F Boeve, Rosa Rademakers
BACKGROUND AND OBJECTIVES: TMEM106B has been proposed as a modifier of disease risk in FTLD-TDP, particularly in GRN mutation carriers. Furthermore, TMEM106B has been investigated as a disease modifier in the context of healthy aging and across multiple neurodegenerative diseases. The objective of this study is to evaluate and compare the effect of TMEM106B on gray matter volume and cognition in each of the common genetic FTD groups and in sporadic FTD patients. METHODS: Participants were enrolled through the ARTFL/LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study, which includes symptomatic and presymptomatic individuals with a pathogenic mutation in C9orf72, GRN, MAPT, VCP, TBK1, TARDBP, symptomatic non-mutation carriers, and non-carrier family controls...
April 5, 2024: medRxiv
#37
Yin Zhang, Sara Lindström, Peter Kraft, Yuxi Liu
IMPORTANCE: Early-onset cancer (diagnosed under 50 years of age) is associated with aggressive disease characteristics and its rising incidence is a global concern. The association between healthy lifestyle and early-onset cancer and whether it varies by common genetic variants is unknown. OBJECTIVE: To examine the associations between genetic risk, lifestyle, and risk of early-onset cancers. DESIGN SETTING AND PARTICIPANTS: We analyzed a prospective cohort of 66,308 white British participants who were under age 50 and free of cancer at baseline in the UK Biobank...
April 6, 2024: medRxiv
#38
JOURNAL ARTICLE
Lingming Kong, Liqin Miu, Wenwei Yao, Zhiyuan Shi
PURPOSE: Mild cognitive impairment (MCI) and depressive disorder (DD), which are associated with unhealthy lifestyles, are prevalent worldwide. This study aimed to investigate the effects of regular aerobic exercise on cognitive function, depression, and the regulatory role of neurotrophic growth factors for providing scientific basis in preventing MCI and DD in healthy individuals. PATIENTS AND METHODS: Eighty members of the fitness center and 80 community residents were recruited, who were administered by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Patient Health Questionnaire (PHQ-9)...
2024: Risk Management and Healthcare Policy
#39
JOURNAL ARTICLE
Ali Abdelfattah, Ayed Zureigat, Alhomidi Almotiri, Mohannad Alzughailat, Mutaz Jamal Al-Khreisat, Osama Abdel Fattah
BACKGROUND/OBJECTIVE: The practice of complementary and alternative medicine has significantly gained acceptance worldwide, such as Al-Hijama, also known as cupping therapy. Despite the growing popularity of therapeutic cupping among athletes, little is known about the impact of cupping therapy on sports fields. The current study was designed to explore the effect of wet cupping therapy on the haematological and inflammatory parameters in Jordanian national team players. METHODS: The procedure was carried out at a specialized centre for cupping in Amman on the morning of the 19th Rajab...
April 15, 2024: Heliyon
#40
Amanda J Bastien, Gene C Liu, Dennis M Tang, Abhita Reddy, Kyohei Itamura, Jack Green, Priya R Soni
A retropharyngeal abscess (RPA) in early childhood is not uncommon due to at-risk lymph nodes in this deep neck space and is typified by fever, odynophagia, and a constellation of respiratory manifestations. However, RPA is exceedingly rare in the neonatal subpopulation and not part of the usual differential diagnosis algorithm in this age range. Herein, we present a unique case of a previously healthy 5-week-old male infant with protracted "congestion" and difficulty in oral feeding, whose clinical course is confounded by intermittent, positional bradycardia and subsequent apnea...
September 2023: Infect Dis Clin Microbiol
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