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https://www.readbyqxmd.com/read/28931225/persistent-herpesvirus-infections-and-telomere-attrition-over-3-years-in-the-whitehall-ii-cohort
#1
Jennifer B Dowd, Jos A Bosch, Andrew Steptoe, Bamini Jayabalasingham, Jue Lin, Robert Yolken, Allison E Aiello
The determinants of telomere attrition, a potential marker of cellular aging, are not well understood. Persistent herpesvirus infections including cytomegalovirus (CMV) infection may be particularly important for telomere dynamics via mechanisms such as inflammation, oxidative stress, and their impact on peripheral blood lymphocyte composition. This study examined the association of 4 human herpesviruses (CMV, herpes simplex virus type 1, human herpesvirus type 6, and Epstein-Barr virus) with change in leukocyte telomere length (LTL) over 3 years in 400 healthy individuals (aged 53-76 years) from the Whitehall II cohort...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28931119/aging-in-the-republic-of-bulgaria
#2
Natalie Pitheckoff
Bulgaria, a southeastern European nation with 7.1 million inhabitants, is ranked 4th in the world for its rate of population aging. Bulgaria has one of the highest proportions of older adults in the world with approximately 20% aged 65 and older. Three main demographic factors have led to rapid population aging. These include emigration, high death rates, and low birth rates. This "perfect storm" of demographic factors has created numerous political, social, and economic challenges for Bulgaria. For example, informal support of older adults is declining as younger generations move abroad or to urban areas for greater employment opportunities...
October 1, 2017: Gerontologist
https://www.readbyqxmd.com/read/28931094/ethnicity-and-skin-autofluorescence-based-risk-engines-for-cardiovascular-disease-and-diabetes-mellitus
#3
Muhammad Saeed Ahmad, Torben Kimhofer, Sultan Ahmad, Mohammed Nabil AlAma, Hala Hisham Mosli, Salwa Ibrahim Hindawi, Dennis O Mook-Kanamori, Katarína Šebeková, Zoheir Abdullah Damanhouri, Elaine Holmes
Skin auto fluorescence (SAF) is used as a proxy for the accumulation of advanced glycation end products (AGEs) and has been proposed to stratify patients into cardiovascular disease (CVD) and diabetes mellitus (DM) risk groups. This study evaluates the effects of seven different ethnicities (Arab, Central-East African, Eastern Mediterranean, European, North African, South Asian and Southeast Asian) and gender on SAF as well as validating SAF assessment as a risk estimation tool for CVD and DM in an Arabian cohort...
2017: PloS One
https://www.readbyqxmd.com/read/28931089/advanced-glycation-end-products-dietary-restriction-effects-on-bacterial-gut-microbiota-in-peritoneal-dialysis-patients-a-randomized-open-label-controlled-trial
#4
Rabi Yacoub, Melinda Nugent, Weijin Cai, Girish N Nadkarni, Lee D Chaves, Sham Abyad, Amanda M Honan, Shruthi A Thomas, Wei Zheng, Sujith A Valiyaparambil, Mark A Bryniarski, Yijun Sun, Michael Buck, Robert J Genco, Richard J Quigg, John C He, Jaime Uribarri
The modern Western diet is rich in advanced glycation end products (AGEs). We have previously shown an association between dietary AGEs and markers of inflammation and oxidative stress in a population of end stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD). In the current pilot study we explored the effects of dietary AGEs on the gut bacterial microbiota composition in similar patients. AGEs play an important role in the development and progression of cardiovascular (CVD) disease. Plasma concentrations of different bacterial products have been shown to predict the risk of incident major adverse CVD events independently of traditional CVD risk factors, and experimental animal models indicates a possible role AGEs might have on the gut microbiota population...
2017: PloS One
https://www.readbyqxmd.com/read/28931027/characteristics-of-informal-caregivers-who-provide-transportation-assistance-to-older-adults
#5
David W Eby, Lisa J Molnar, Lidia P Kostyniuk, Renée M St Louis, Nicole Zanier
The study aim was to gain a better understanding of the characteristics of informal caregivers who provide transportation assistance and to explore the types and frequency of this assistance. A telephone survey was administered to a representative sample of 268 informal caregivers (age 45-80) who provide transportation assistance to older adults (age 70 and older) in Michigan. Responses were analyzed overall and by the caregiver sex and care recipient age. Informal transportation caregivers were: most often women; on average 61 years old; generally college educated; employed full- or part-time jobs; relatively healthy; providing care to a parent/family member 1-4 times per week, living close to the care recipient; and providing assistance by giving rides...
2017: PloS One
https://www.readbyqxmd.com/read/28930927/oral-behaviors-and-parafunctions-comparison-of-temporomandibular-dysfunction-patients-and-controls
#6
Marijus Leketas, Viktoras Šaferis, Ričardas Kubilius, Gabriele Cervino, Ennio Bramanti, Marco Cicciù
The aim of this study is to evaluate the frequency of oral behaviors in patients with temporomandibular disorders (TMD) and a control group without TMD.In this baseline case-control study, 260 controls and 260 subjects with TMD completed the oral behaviors checklist defined as a "self-report scale for identifying and quantifying the frequency of jaw overuse behavior" and underwent clinical examinations using the DC/TMJ international examination form (version May 12, 2013). Relationships of oral parafunctions' frequencies between groups were examined...
September 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28930922/why-and-when-social-support-predicts-older-adults-pain-related-disability-a-longitudinal-study
#7
Marta Matos, Sónia F Bernardes, Liesbet Goubert
Pain-related social support has been shown to be directly associated with pain-related disability, depending on whether it promotes functional autonomy or dependence. However, previous studies mostly relied on cross-sectional methods, precluding conclusions on the temporal relationship between pain-related social support and disability. Also, research on the behavioral and psychological processes that account for such a relationship is scarce. Therefore, this study aimed at investigating the following longitudinally: (1) direct effects of social support for functional autonomy/dependence on pain-related disability, (2) mediating role of physical functioning, pain-related self-efficacy, and fear, and (3) whether pain duration and pain intensity moderate such mediating processes...
October 2017: Pain
https://www.readbyqxmd.com/read/28930832/early-central-and-peripheral-corneal-microstructural-changes-in-type-2-diabetes-mellitus-patients-identified-using-in-vivo-confocal-microscopy-a-case-control-study
#8
Jing-Hao Qu, Lei Tian, Xiao-Yu Zhang, Xu-Guang Sun
The aim of this study was to find early central and peripheral corneal microstructural changes in healthy subjects and type 2 diabetes mellitus (T2DM) patients with/without cornea fluorescein dot staining.This is a prospective case-control study of T2DM patients with/without cornea fluorescein dot staining. Age, sex, duration of diabetes, and serum glycosylated hemoglobin A1c (HbA1c) levels were recorded. Keratograph 5 M (K5 M) and in vivo confocal microscopy were performed on all subjects. The cornea was divided into 5 zones: central, superior, temporal, nasal, and inferior...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930478/mechanical-ventilation-induced-diaphragm-atrophy-strongly-impacts-clinical-outcomes
#9
Ewan C Goligher, Martin Dres, Eddy Fan, Gordon D Rubenfeld, Damon C Scales, Margaret S Herridge, Stefannie Vorona, Michael C Sklar, Nuttapol Rittayamai, Ashley Lanys, Alistair Murray, Deborah Brace, Cristian Urrea, W Darlene Reid, George Tomlinson, Arthur S Slutsky, Brian P Kavanagh, Laurent J Brochard, Niall D Ferguson
Rationale Diaphragm dysfunction worsens outcomes in mechanically ventilated patients but the clinical impact of potentially preventable changes in diaphragm structure and function due to mechanical ventilation is unknown. Objectives To determine whether diaphragm atrophy developing during mechanical ventilation leads to prolonged ventilation. Methods Diaphragm thickness was measured daily by ultrasound in adults requiring invasive mechanical ventilation; inspiratory effort was assessed by thickening fraction...
September 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28930378/the-risk-of-metabolic-syndrome-in-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#10
REVIEW
Samira Behboudi-Gandevani, Mina Amiri, Raziyeh Bidhendi Yarandi, Mahsa Noroozzadeh, Maryam Farahmand, Marziyeh Rostami Dovom, Fahimeh Ramezani Tehrani
BACKGROUND AND OBJECTIVE: Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder associated with metabolic syndrome (MetS). The aim of this systematic review and meta-analysis was to provide the most reliable estimate risk of MetS in women with PCOS, compared to healthy controls. METHODS: A comprehensive literature search was performed in PubMed [including Medline], Web of Science and Scopus databases for retrieving articles in English language on the prevalence/incidence and odds of MetS in women with PCOS compared to healthy controls...
September 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28930364/nutritional-risk-hospitalization-and-mortality-among-community-dwelling-canadians-aged-65-or-older
#11
Pamela L Ramage-Morin, Heather Gilmour, Michelle Rotermann
BACKGROUND: Nutritional risk has been associated with various negative health outcomes among older people. Limited longitudinal research has examined the relationship between nutritional risk and hospitalization and death in community-dwelling older people. DATA AND METHODS: Data from the 2008/2009 Canadian Community Health Survey-Healthy Aging (CCHS-HA) linked to the Discharge Abstract Database and the Canadian Mortality Database were used to estimate the prevalence of nutritional risk among seniors and examine its relationship with acute care hospitalization and death during the 25- to 36-month period following the CCHS-HA interview...
September 20, 2017: Health Reports
https://www.readbyqxmd.com/read/28930223/successful-pregnancy-after-treatment-with-chinese-herbal-medicine-in-a-43-year-old-woman-with-diminished-ovarian-reserve-and-multiple-uterus-fibrosis-a-case-report
#12
Benqi Teng, Jie Peng, Madeleine Ong, Xianqin Qu
OBJECTIVE: To highlight a natural approach to coexisting oligomenorrhea, subfertility, luteal phase insufficiency and multiple fibroids cohesively when in vitro fertilisation (IVF) has failed. CASE PRESENTATION: A 43-year-old woman with diminished ovarian reserve and multiple uterine fibroids had previously been advised to discontinue IVF treatment. According to Chinese Medicine diagnosis, herbal formulae were prescribed for improving age-related ovarian insufficiency as well as to control the growth of fibroids...
February 9, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929999/effects-of-cognitive-training-on-cognitive-performance-of-healthy-older-adults
#13
Mariana Teles Santos Golino, Carmen Flores Mendoza, Hudson Fernandes Golino
The purpose of this study was to determine the immediate effects of cognitive training on healthy older adults and verify the transfer effects of targeted and non-targeted abilities. The design consisted of a semi-randomized clinical controlled trial. The final sample was composed of 80 volunteers recruited from a Brazilian community (mean age = 69.69; SD = 7.44), which were separated into an intervention group (N = 47; mean age = 69.66, SD = 7.51) and a control group (N = 33; mean age = 69.73, SD = 7.45). Intervention was characterized by adaptive cognitive training with 12 individual training sessions of 60 to 90 minutes (once a week)...
September 20, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/28929941/long-term-predictors-of-stroke-in-healthy-middle-aged-men
#14
Erik Prestgaard, Christian Hodnesdal, Kristian Engeseth, Jan Erikssen, Johan Bodegård, Knut Liestøl, Knut Gjesdal, Sverre E Kjeldsen, Irene Grundvold, Eivind Berge
Background There are few data on risk factors for stroke during long-term follow-up of healthy individuals. Aims We aimed to investigate the long-term predictive impact on stroke risk of baseline variables including hemodynamic variables measured at rest and during exercise in middle-aged, healthy men. Methods We performed a prospective cohort study of 2014 healthy Norwegian men aged 40-59 years, recruited during the period 1972-1975 and followed until 2007. Participants underwent a comprehensive clinical assessment at baseline, including a bicycle exercise test...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28929866/culture-and-food-practices-of-african-american-women-with-type-2-diabetes
#15
Lisa L Sumlin, Sharon A Brown
Purpose The goals of this descriptive ethnographic study were to (1) describe the day-to-day selection, preparation, and consumption of food among African American women (AAW) with type 2 diabetes mellitus (T2DM); (2) identify their typical food selections and consumption practices when dining out at restaurants and at social gatherings (ie, church functions, holidays); (3) highlight the valued behaviors and beliefs that influence these women's food practices; and (4) determine how social interactions influence those food practices...
September 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28929726/-factors-associated-to-medical-visits-comparison-among-italians-and-immigrants-resident-in-italy
#16
Anteo Di Napoli, Monica Perez, Alessandra Rossi, Daniele Spizzichino, Laura Iannucci, Lidia Gargiulo, Daniela Panaccione, Concetta Mirisola, Alessio Petrelli
OBJECTIVES: to evaluate the role of factors potentially associated with the use of medical visits by the immigrant population living in Italy, making a comparison with the Italian population. DESIGN: cross-sectional study based on the representative sample of the population residing in Italy considered in the Survey "Health and use of health services" conducted by the Italian National Institute of Statistics (Istat) in 2013. SETTING AND PARTICIPANTS: the study was conducted on a sample of citizens aged 18-64 years (72,476 individuals) representing a population of 37,290,440 residents in Italy (33...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28929722/-self-perceived-health-status-among-immigrants-in-italy
#17
Alessio Petrelli, Anteo Di Napoli, Alessandra Rossi, Lidia Gargiulo, Concetta Mirisola, Gianfranco Costanzo
OBJECTIVES: to evaluate self-perceived health status of immigrants in Italy. DESIGN: cross-sectional study based on the representative national samples of the multipurpose surveys "Health conditions and use of health services" conducted in 2005 and 2013 by the Italian National Institute of Statistics (Istat). SETTING AND PARTICIPANTS: the study was conducted on the age group of 18-64: No. 80,661 in 2005, among which 3.2% were immigrants, and No...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28929716/-developing-an-algorithm-based-on-health-and-social-sources-to-stratify-general-population-in-different-levels-of-health-socio-sanitary-frailty-and-disability
#18
Laura Andreoni, Antonio Giampiero Russo
OBJECTIVES: to describe an innovative algorithm to classify the general population, in homogeneous groups of severity and complexity of disease and real needs, by using three dimensions: health, frailty, and disability. DESIGN: retrospective cohort study. SETTING AND PARTICIPANTS: the study includes the population covered by the Agency for health protection of Metropolitan Area of Milan (3,4 million of habitants). We identified two cohorts of residents: the first at 01...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28929564/prefronto-temporal-white-matter-microstructural-alterations-20%C3%A2-years-after-the-diagnosis-of-type-1-diabetes-mellitus
#19
Sujung Yoon, Jungyoon Kim, Gail Musen, Perry F Renshaw, Jaeuk Hwang, Nicolas R Bolo, Jieun E Kim, Donald C Simonson, Katie Weinger, Christopher M Ryan, In Kyoon Lyoo, Alan M Jacobson
OBJECTIVE: Microvascular pathophysiology that uniquely manifests as white matter (WM) abnormalities is often implicated in type 1 diabetes mellitus (T1DM)-related central nervous system (CNS) complications. This study sought to identify regional WM abnormalities in young adults diagnosed with T1DM and further examine their association with cognitive and emotional dysfunction. RESEARCH DESIGN AND METHODS: Diffusion tensor images (DTI) obtained from 34 young adults with T1DM for ≥15 years (mean duration, 20...
September 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28929532/the-impact-of-left-ventricular-deformation-and-dyssynchrony-on-improvement-of-left-ventricular-ejection-fraction-following-radiofrequency-catheter-ablation-in-wolff-parkinson-white-syndrome-a-comprehensive-study-by-speckle-tracking-echocardiography
#20
Tomoo Nagai, Akira Hamabe, Junko Arakawa, Hirotsugu Tabata, Toshihiko Nishioka
PURPOSE: The purpose of this study was to evaluate left ventricular (LV) deformation and LV dyssynchrony in patients with Wolff-Parkinson-White (WPW) syndrome and to identify the factors that affect the efficacy of radiofrequency catheter ablation (RFCA). METHODS: Thirty patients (26 men, mean age 40 ± 12 years) with WPW syndrome were prospectively recruited for this study. They underwent 2-dimensional transthoracic echocardiography with speckle tracking analysis before RFCA and again within 48 hours after RFCA...
September 19, 2017: Echocardiography
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