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https://www.readbyqxmd.com/read/28531762/high-dose-testosterone-enanthate-supplementation-boosts-oxidative-stress-but-exerts-little-effect-on-the-antioxidant-barrier-in-sedentary-adolescent-male-rat-liver
#1
Ewa Sadowska-Krepaa, Barbara Klapcinępa, Barbara Kłapcińska, Sławomir Jagsz, Anna Nowara, Izabela Szołtysek-Bołdys, Małgorzata Chalimoniuk, Józef Langfort, Stanisław J Chrapusta
BACKGROUND: Anabolic-androgenic steroids abuse is on the rise among adolescent boys and young men, mostly in those seeking a 'shortcut' to an improved body image. This approach is associated with the risk of severe adverse health effects, some of which involve the liver and are linked to hepatic oxidative stress. Testosterone and its esters is a cornerstone of most anabolic-androgenic steroid stacking protocols. METHODS: We assessed and compared several hepatotoxicity and liver oxidative stress indices, as well as the contents of some components of the hepatic antioxidant barrier between sedentary adolescent male rats given a 6-week course of weekly im testosterone enanthate (TE, 8 or 80mg/kgBW/week) or vehicle (sesame oil) injections...
March 11, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28531761/3%C3%AE-hydroxy-urs-12-en-28-oic-acid-confers-protection-against-znonps-induced-adversity-in-caenorhabditis-elegans
#2
Hema Negi, Shilpi Khare Saikia, Ranjana Kanaujia, Satish Jaiswal, Rakesh Pandey
Despite their well reported potent risk towards human health and environment Zinc oxide nanoparticles (ZnONPs) find an extensive commercial usage due to their antimicrobial properties. Here, we evaluated the efficacy of a natural triterpene ursolic acid (3β-hydroxy-urs-12-en-28-oic acid; UA) for overcoming the cytotoxic challenges of ZnONPs employing Ceanorhabditis elegans. The 24h LC50 of Zn-ONPs (<50nm TEM) was deduced as 4.75mgL(-1). UA (25μM) was observed to defend against this toxicity by attenuating Reactive Oxygen Species (ROS) resulting into better survival at 2mgL(-1) in a time dependent behavior...
May 8, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28531190/real-time-cell-toxicity-profiling-of-tox21-10k-compounds-reveals-cytotoxicity-dependent-toxicity-pathway-linkage
#3
Jui-Hua Hsieh, Ruili Huang, Ja-An Lin, Alexander Sedykh, Jinghua Zhao, Raymond R Tice, Richard S Paules, Menghang Xia, Scott S Auerbach
Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U.S. Tox21 screening program, the cytotoxicity of ~10K chemicals was interrogated at 0, 8, 16, 24, 32, & 40 hours of exposure in a concentration dependent fashion in two cell lines (HEK293, HepG2) using two multiplexed, real-time assay technologies. One technology measures the metabolic activity of cells (i.e., cell viability, glo) while the other evaluates cell membrane integrity (i.e., cell death, flor). Using glo technology, more actives and greater temporal variations were seen in HEK293 cells, while results for the flor technology were more similar across the two cell types...
2017: PloS One
https://www.readbyqxmd.com/read/28528893/body-temperature-responses-to-handling-stress-in-wintering-black-capped-chickadees-poecile-atricapillus-l
#4
Agnès Lewden, Andreas Nord, Magali Petit, François Vézina
Body temperature variation in response to acute stress is typically characterized by peripheral vasoconstriction and a concomitant increase in core body temperature (stress-induced hyperthermia). It is poorly understood how this response differs between species and within individuals of the same species, and how it is affected by the environment. We therefore investigated stress-induced body temperature changes in a non-model species, the Black-capped Chickadee, in two environmental conditions: outdoors in low ambient temperature (mean: -6...
May 18, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28528799/a-multifactorial-obesity-model-developed-from-nationwide-public-health-exposome-data-and-modern-computational-analyses
#5
LisaAnn S Gittner, Barbara J Kilbourne, Ravi Vadapalli, Hafiz M K Khan, Michael A Langston
STATEMENT OF THE PROBLEM: Obesity is both multifactorial and multimodal, making it difficult to identify, unravel and distinguish causative and contributing factors. The lack of a clear model of aetiology hampers the design and evaluation of interventions to prevent and reduce obesity. METHODS: Using modern graph-theoretical algorithms, we are able to coalesce and analyse thousands of inter-dependent variables and interpret their putative relationships to obesity...
May 18, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28527764/differential-stress-response-of-saccharomyces-hybrids-revealed-by-monitoring-hsp104-aggregation-and-disaggregation
#6
Claudia Kempf, Klaus Lengeler, Jürgen Wendland
Proteotoxic stress may occur upon exposure of yeast cells to different stress conditions. The induction of stress response mechanisms is important for cells to adapt to changes in the environment and ensure survival. For example, during exposure to elevated temperatures the expression of heat shock proteins such as Hsp104 is induced in yeast. Hsp104 extracts misfolded proteins from aggregates to promote their refolding. We used an Hsp104-GFP reporter to analyze the stress profiles of Saccharomyces species hybrids...
July 2017: Microbiological Research
https://www.readbyqxmd.com/read/28527016/chemical-derivatization-of-metabolite-mass-profiling-of-the-recretohalophyte-aeluropus-lagopoides-revealing-salt-stress-tolerance-mechanism
#7
Murali Krishna Paidi, Parinita Agarwal, Prashant More, Pradeep K Agarwal
Plants are the primary producers of food for human being. Their intracellular environment alternation is influenced by abiotic stress factors such as drought, heat and soil salinity. Aeluropus lagopoides is a strong halophyte that grows with ease under high saline muddy banks of creeks of Gujarat, India. To study the response of salinity on metabolite changes in Aeluropus, three treatments, i.e. control, salinity and recovery, were selected for both shoot and root tissue. The cytosolic metabolite state was analysed by molecular chemical derivatization gas chromatography mass profiling...
May 19, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28526786/impact-of-acanthamoeba-cysts-on-stress-resistance-of-salmonella-enterica-serovar-typhimurium-yersinia-enterocolitica-4-o-3-listeria-monocytogenes-1-2a-and-escherichia-coli-o-26
#8
Ellen Lambrecht, Julie Baré, Koen Sabbe, Kurt Houf
The formation of robust resting cysts enables Acanthamoeba to resist harsh environmental conditions. This study investigated to what extent these cysts are resistant to physical and chemical stresses as applied in food industry cleaning and disinfection procedures. Moreover it was assessed whether certain intracystic meatborne bacterial pathogens are more stress-resistant than free-living bacterial monocultures and if intracystic passage and subsequent association with trophozoites induces cross-tolerance towards other stressors...
May 19, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28526328/acrylamide-induced-neurotoxicity-in-primary-astrocytes-and-microglia-roles-of-the-nrf2-are-and-nf-%C3%AE%C2%BAb-pathways
#9
Mengyao Zhao, Fu Sheng Lewis Wang, Xiaosong Hu, Fang Chen, Hing Man Chan
Acrylamide (AA) is a common food contaminant formed during food heat processing that has neurotoxic effects. We hypothesize that AA induces oxidative stress in astrocytes and microglia, leading to neurotoxicity. Oxidative status, translocation of Nrf2 and NF-κB, and related down-stream targets were measured in primary astrocytes and microglia obtained from BALB/c mice. The results showed that AA increased reactive oxygen species (ROS) formation and reduced glutathione levels, causing successive events associated with oxidative stress, including 4-hydroxynonenal and 8-hydroxy-2-deoxyguanosine adduct formation, in both cell types...
May 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28525284/intrinsically-disordered-proteins-as-important-players-during-desiccation-stress-of-the-soybean-radicles
#10
Yun Liu, Jiahui Wu, Nan Sun, Chengjian Tu, Xiaoying Shi, Hua Cheng, Simu Liu, Shuiming Li, Yong Wang, Yizhi Zheng, Vladimir N Uversky
Intrinsically disordered proteins (IDPs) play a variety of important physiological roles in all living organisms. However, there is no comprehensive analysis of the abundance of IDPs associated with environmental stress in plants. Here, we show that a set of heat-stable proteins (i.e., proteins that do not denature after boiling at 100°C for 10 min) was present in R0mm and R15mm radicles (i.e., before the radicle emergence and the 15 mm long radicles) of soybean (Glycine max) seeds. This set of 795 iTRAQ-quantified heat-stable proteins contained a high proportion of wholly or highly disordered proteins (15%), which was significantly higher than that estimated for the whole soybean proteome containing 55,787 proteins (9%)...
May 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28523389/effects-of-calving-season-on-the-voluntary-waiting-period-and-reproductive-performance-of-holstein-cows-in-the-tropical-savannah
#11
Thiago Vilar Silva, Benner Geraldo Alves, Kele Amaral Alves, Regiani Nascimento Gagno Porto, Maria Lucia Gambarini
The effects of calving season [rainy (RS) and dry (DS)] on the voluntary waiting period (VWP) of 58 Holstein cows raised in the tropical savannah were investigated using data of temperature humidity index (THI), total antioxidant status (TAS), respiratory rate (RR), rectal temperature (RT), glucose, total cholesterol (TC), triglycerides (TG), velocity of uterine regression, and subsequent reproductive performance. Blood samples and clinical data were taken once every week, from calving until the sixth postpartum week...
May 18, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28522415/behavioural-adaptation-of-the-rice-leaf-folder-cnaphalocrocis-medinalis-to-short-term-heat-stress
#12
Muhammad Adnan Bodlah, Ling-Ling Gu, Ye Tan, Xiang-Dong Liu
Under ongoing climate warming, both the degree and number of high-temperature events in summer may increase, and behavioural adaptation is an important ecological strategy employed by insects to cope with such events. The rice leaf folder, Cnaphalocrocis medinalis Güenée, is a serious insect pest of rice fields in summer. Population outbreaks have become more frequent in the last ten years. In addition to adult migration, rice leaf folders are thought to have other thermal adaptations. Therefore, the behaviours of larval and adult rice leaf folders, such as leaf folding (making shelter) and habitat selection for pupae and eggs, were observed on rice plants under heat stress...
May 15, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28522335/comparative-analysis-of-transcriptomic-responses-to-repeated-dose-exposure-to-2-mcpd-and-3-mcpd-in-rat-kidney-liver-and-testis
#13
Thorsten Buhrke, Katharina Schultrich, Albert Braeuning, Alfonso Lampen
3-Chloro-1,2-propanediol (3-MCPD) and its isomer 2-chloro-1,3-propanediol (2-MCPD) are heat-induced food contaminants present in oil- and fat-containing foodstuff. Kidney and testes are among the main target organs of 3-MCPD. Almost no data on 2-MCPD toxicity are available. Here, transcriptomic responses following repeated-dose exposure of rats to non-toxic doses of 10 mg/kg body weight 2-MCPD or 3-MCPD for 28 days were characterized by microarray analysis of kidney, liver, and testes. 3-MCPD exerted more pronounced effects than 2-MCPD in all organs...
May 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28521848/impacts-of-stocking-density-on-development-and-puberty-attainment-of-replacement-beef-heifers
#14
K M Schubach, R F Cooke, A P Brandão, K D Lippolis, L G T Silva, R S Marques, D W Bohnert
In all, 60 Angus×Hereford heifers were ranked by age and BW (210±2 days and 220±2 kg) on day 0, and assigned to: (a) one of three drylot pens (10×14 m pens; 10 heifers/pen) resulting in a stocking density of 14 m2/heifer (HIDENS; n=3), or (b) one of three pastures (25 ha pastures; 10 heifers/pasture), resulting in a stocking density of 25 000 m2/heifer (LOWDENS; n=3). Pastures were harvested for hay before the beginning of this experiment, and negligible forage was available for grazing to LOWDENS heifers during the experiment (days 0 to 182)...
May 19, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28521568/prion-based-memory-of-heat-stress-in-yeast
#15
Tatiana A Chernova, Yury O Chernoff, Keith D Wilkinson
Amyloids and amyloid-based prions are self-perpetuating protein aggregates which can spread by converting a normal protein of the same sequence into a prion form. They are associated with diseases in humans and mammals, and control heritable traits in yeast and other fungi. Some amyloids are implicated in biologically beneficial processes. As prion formation generates reproducible memory of a conformational change, prions can be considered as molecular memory devices.  We have demonstrated that in yeast, stress-inducible cytoskeleton-associated protein Lsb2 forms a metastable prion in response to high temperature...
May 19, 2017: Prion
https://www.readbyqxmd.com/read/28521110/ethanol-induced-stress-response-of-staphylococcus-aureus
#16
Jasmine M Pando, Richard F Pfeltz, Jesus A Cuaron, Vijayaraj Nagarajan, Mukti N Mishra, Nathanial J Torres, Mohamed O Elasri, Brian J Wilkinson, John E Gustafson
Transcriptional profiles of two unrelated clinical methicillin-resistant S. aureus (MRSA) isolates were analyzed following 10 % v/v ethanol challenge (15 min), which arrested growth but did not reduce viability. Ethanol-induced stress (EIS) resulted in differential gene expression of 1091 genes, 600 common to both strains, of which 291 were up-regulated. With the exception of the down-regulation of genes involved with osmotic stress functions, EIS resulted in the up-regulation of genes that contribute to stress response networks, notably those altered by oxidative stress, protein quality control in general, and heat shock in particular...
May 18, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28520817/heat-in-the-southeastern-united-states-characteristics-trends-and-potential-health-impact
#17
Jeremy E Diem, Christine E Stauber, Richard Rothenberg
High summer temperatures in extratropical areas have an impact on the public's health, mainly through heat stress, high air pollution concentrations, and the transmission of tropical diseases. The purpose of this study is to examine the current characteristics of heat events and future projections of summer apparent temperature (AT)-and associated health concerns-throughout the southeastern United States. Synoptic climatology was used to assess the atmospheric characteristics of extreme heat days (EHDs) from 1979-2015...
2017: PloS One
https://www.readbyqxmd.com/read/28517368/testicular-thermoregulation-scrotal-surface-temperature-patterns-and-semen-quality-of-water-buffalo-bulls-reared-in-a-tropical-climate
#18
L K X Silva, J S Sousa, A O A Silva, J B Lourenço Junior, C Faturi, L G Martorano, I M Franco, M H A Pantoja, D V Barros, A R Garcia
This study evaluated the capacity of thermoregulation and its consequences on the scrotal surface temperature patterns and semen quality of buffalo bulls raised in a wet tropical climate. Eleven water buffaloes were evaluated in the rainiest, in the transitional and in the less rainy season. Air temperature and humidity were consistently high, but the animals did not show thermal stress in any season. The scrotal temperature gradient of buffalo bulls using infrared thermography was described, and three parallel and decreasing thermal bands were characterised...
May 18, 2017: Andrologia
https://www.readbyqxmd.com/read/28516732/diadenosine-tetraphosphate-ap4a-an-e-coli-alarmone-or-a-damage-metabolite
#19
Dragana Despotović, Alexander Brandis, Alon Savidor, Yishai Levin, Laura Fumagalli, Dan S Tawfik
Under stress, metabolism is changing: specific up- or down-regulation of proteins and metabolites occurs as well as side-effects. Distinguishing specific stress-signaling metabolites (alarmones) from side-products (damage metabolites) is not trivial. One example is diadenosine tetraphosphate, Ap4A - a side-product of aminoacyl-tRNA synthetases found in all domains of life. The earliest observations suggested that Ap4A serves as an alarmone for heat stress in E. coli. However, despite 50 years of research, the signaling mechanisms associated with Ap4A remain unknown...
May 18, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28516150/proteome-dataset-of-subcutaneous-adipose-tissue-obtained-from-late-pregnant-dairy-cows-during-summer-heat-stress-and-winter-seasons
#20
M Zachut, G Kra, L Livshitz, Y Portnick, S Yakoby, G Friedlander, Y Levin
Adipose tissue has a central role in the regulation of metabolism in dairy cows, and many proteins expressed in this tissue are involved in metabolic responses to stress (Peinado et al., 2012) [1]. Environmental heat stress is one of the main stressors limiting production in dairy cattle (Fuquay, 1981; West, 2003) [2], [3], and there is a complex interaction between heat stress and the transition period from late pregnancy to onset of lactation, which is manifested in heat-stressed late-gestation cows (Tao and Dahl, 2013) [4]...
June 2017: Data in Brief
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