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https://www.readbyqxmd.com/read/29679484/the-role-of-autoimmune-reactivity-induced-by-heat-shock-protein-70-in-the-pathogenesis-of-essential-hypertension
#1
REVIEW
Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
Autoimmunity is increasingly recognized as having a central role in essential hypertension. Heat shock proteins are immunodominant molecules with high interspecies homology and autoimmune reactivity directed against HSP70 may play a role in the pathogenesis of hypertension. Autoimmunity to HSP70 may result from molecular mimicry between human HSP and bacterial HSP, or alternatively, as a response to HSP70-peptide complexes generated during cellular stress and delivered to the major histocompatibility complex in antigen presenting cells...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29678739/atpase-activity-of-groel-is-dependent-on-groes-and-it-is-response-for-environmental-stress-in-riemerella-anatipestifer
#2
Jibin Liu, Mingshu Wang, Haibo Yi, Mafeng Liu, Dekang Zhu, Ying Wu, Renyong Jia, Kunfeng Sun, Qiao Yang, Shun Chen, Xinxin Zhao, Xiaoyue Chen, Anchun Cheng
Riemerella anatipestifer (Ra) is a serious gram-negative pathogen of birds and can cause considerable economic losses. The survival mechanisms of R. anatipestifer in the host and environment remain largely unknown. Previous results have demonstrated that GroEL is a molecular chaperone and an important component of the response to various stresses in most bacteria. This study focused on whether GroEL is implicated in this process in R. anatipestifer. The 1629 bp groEL is highly conserved among other gram-negative bacteria (levels of sequence similarity > 60%)...
April 17, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29678721/acute-tissue-reactions-inner-segment-pathology-and-effects-of-the-antioxidant-%C3%AE-1-microglobulin-in-an-in-vitro-model-of-retinal-detachment
#3
Fredrik Ghosh, Bo Åkerström, Jesper Bergwik, Hodan Abdshill, Lina Gefors, Linnéa Taylor
The purpose of this study was to explore acute tissue reactions, ultrastructural photoreceptor morphology with emphasis on inner segments, and the effect of antioxidant treatment in an in vitro model of rhegmatogenous retinal detachment (RRD). A previously described method of RRD simulation was used with adult retinal porcine explants kept free-floating in culture medium with or without treatment with the radical scavenger α1 -microglobulin (A1M). Explants were examined at 5 time points from 1 to 24 h using transmission electron microscopy as well as quantitative real-time PCR (RT-PCR) to quantify gene expression of the cell stress marker heat shock protein 70 (Hsp70) and oxidative stress marker heme oxygenase (HO-1)...
April 17, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29677632/heat-shock-induced-cathepsin-b-activity-during-ivf-and-culture-compromises-the-developmental-competence-of-bovine-embryos
#4
Ken-Ichi Yamanaka, Hafiza Khatun, Junki Egashira, Ahmed Zaky Balboula, Hideki Tatemoto, Miki Sakatani, Naoki Takenouchi, Yasuhiko Wada, Masashi Takahashi
Heat stress can cause significant reproductive dysfunction in mammals and previous studies report that expression and activity of cathepsin B (CTSB), a lysosomal cysteine protease, is negatively correlated with the developmental competence of bovine oocytes and embryos. However, the relationship between heat shock (HS) and CTSB remains largely unknown. Here, we investigated the effects of HS during IVF and early embryonic stages of IVC on CTSB activity and developmental competence in bovine embryos. HS (40 °C for 6 h during IVF and 20 h during IVC) caused a significant increase in CTSB activity irrespective of the developmental stage or duration of HS...
April 6, 2018: Theriogenology
https://www.readbyqxmd.com/read/29677000/stress-resistance-and-lifespan-enhanced-by-downregulation-of-antimicrobial-peptide-genes-in-the-imd-pathway
#5
Yuh-Ru Lin, Hardik Parikh, Yongkyu Park
Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18°C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat) in the body than development at 25°C. Gene expression analysis between the flies developed at 18°C and 25°C revealed that the Immune deficiency (Imd) pathway, including the downstream antimicrobial peptides (AMPs), is downregulated in the flies developed at 18°C. When hypomorphic imd mutant flies with reduced AMP expressions were developed at 25°C, they showed induced stress resistance with higher fat content in the body similar to the wild-type flies developed at 18°C...
April 19, 2018: Aging
https://www.readbyqxmd.com/read/29676863/nitrite-stress-disrupts-the-structural-integrity-and-induces-oxidative-stress-response-in-the-intestines-of-pacific-white-shrimp-litopenaeus-vannamei
#6
Yafei Duan, Jiasong Zhang, Yun Wang, Qingsong Liu, Dalin Xiong
The acute toxicity of nitrite on the mucosal morphology and oxidative stress response was investigated in the intestines of Litopenaeus vannamei after the exposure of 20 mg/L nitrite for 72 hr. The duration of nitrite stress influenced the shrimp survival, and the cumulative mortality rate was 36.7% at 72 hr. Hematoxylin and eosin (HE) stain showed that nitrite stress damaged the intestine connective and epithelium tissue. Specifically, nitrite stress increased the content of reactive oxygen species (ROS) production (O2 - generation capacity), lipid peroxidation (LPO), and malondialdehyde (MDA)...
April 20, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29676438/the-influence-of-digit-size-and-proportions-on-dexterity-during-cold-exposure
#7
Stephanie Payne, Alison Macintosh, Jay Stock
OBJECTIVES: The current study investigated whether size and proportions of the hands and digits affect dexterity during severe cold exposure. As wide hands are known to lose less heat than narrow hands, and narrow digits are associated with greater dexterity, this study aimed to test whether there was a direct trade-off between dexterity and thermoregulation that shapes hand morphology. METHODS: Participants (25 women, 15 men) carried out the Purdue Pegboard test before and after a 3-min ice-water immersion of the hand...
April 20, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29676416/self-plied-and-twist-stable-carbon-nanotube-yarn-artificial-muscles-driven-by-organic-solvent-adsorption
#8
Kaiyun Jin, Silan Zhang, Susheng Zhou, Jian Qiao, Yanhui Song, Jiangtao Di, Dengsong Zhang, Qingwen Li
Artificial yarn/fiber muscles have recently attracted considerable interest for various applications. These muscles can provide large-stroke tensile and torsional actuations, resulting from inserted twists. However, tensional tethering of twisted muscles is generally needed to avoid muscle snarling and untwisting. In this paper a carbon nanotube (CNT) yarn muscle that is tethering-free and twist-stable is reported. The yarn muscle is prepared by allowing the self-plying of a coiled CNT yarn. When driven by acetone adsorption, this muscle shows decoupled actuations, which provide fast and reversible ∼13...
April 20, 2018: Nanoscale
https://www.readbyqxmd.com/read/29675862/hemodialysis-a-model-for-extreme-physiology-in-a-vulnerable-patient-population
#9
REVIEW
Jeroen P Kooman, Krassimir Katzarski, Frank M van der Sande, Karel M Leunissen, Peter Kotanko
Hemodialysis (HD) is a lifesaving treatment for patients with end-stage renal disease, which is very efficient in the correction of abnormalities of the internal environment. However, this efficiency also induces significant hemodynamic, thermal, and respiratory stressors. These have parallels with the extreme physiologic demands which are normally mainly experienced by healthy subjects under adverse environmental conditions, with the difference that they must be endured by a vulnerable patient population. Hemodynamic stress induced by ultrafiltration leads to a decline in circulating blood volume, which may result in intradialytic hypotension (IDH) and changes in tissue perfusion, which may have long-term consequences for the function of vital organs such as the brain and the heart...
April 19, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29675858/effect-of-heat-treatment-on-the-microstructure-and-properties-of-ni-based-soft-magnetic-alloy
#10
Chunhong Li, Hui Ruan, Dengming Chen, Kejian Li, Donglin Guo, Bin Shao
A Ni-based alloy was heat treated by changing the temperature and ambient atmosphere of the heat treatment. Morphology, crystal structure, and physical performance of the Ni-based alloy were characterized via SEM, XRD, TEM, and PPMS. Results show that due to the heat treatment process, the grain growth of the Ni-based alloy and the removal of impurities and defects are promoted. Both the orientation and stress caused by rolling are reduced. The permeability and saturation magnetization of the alloy are improved...
April 20, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29673612/molecular-mechanisms-of-combined-heat-and-drought-stress-resilience-in-cereals
#11
REVIEW
Lovely Mae F Lawas, Ellen Zuther, Sv Krishna Jagadish, Dirk K Hincha
Global climate change leads to increased temperatures and decreased precipitation in many parts of the world. The simultaneous occurrence of high temperature and water deficit results in heat stress damage in plants. Cereals provide the majority of calories for human consumption, making this stress scenario particularly threatening for global food security. Several studies in both dicots and cereals indicate that the molecular reactions of plants to combined stresses cannot be predicted from reactions to single stresses...
April 16, 2018: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29673428/ice-slurry-ingestion-and-physiological-strain-during-exercise-in-non-compensable-heat-stress
#12
Jason Ng, Jonathan E Wingo, Phillip A Bishop, Jason C Casey, Elizabeth K Aldrich
INTRODUCTION: Precooling with ice slurry ingestion attenuates the increase in rectal temperature (Tre) during subsequent running and cycling. It remains unclear how this cooling method affects physiological strain during work while wearing protective garments. This study investigated the effect of ice slurry ingestion on physiological strain during work in hot conditions while wearing firefighter protective clothing. METHODS: In three counterbalanced trials, eight men (mean ± SD; age = 21 ± 2 yr, height = 179...
May 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29673186/identification-expression-analysis-of-the-hsf-family-and-characterization-of-class-a4-in-sedum-alfredii-hance-under-cadmium-stress
#13
Shuang-Shuang Chen, Jing Jiang, Xiao-Jiao Han, Yun-Xing Zhang, Ren-Ying Zhuo
Sedum alfredii Hance, a cadmium (Cd)/zinc (Zn)/lead (Pb) co-hyperaccumulating species, is a promising phytoremediation candidate because it accumulates substantial amounts of heavy metal ions without showing any obvious signs of poisoning. The heat shock transcription factor (Hsf) family plays crucial roles in plant growth, development, and stress responses. Although the roles of some Hsfs in abiotic stress have been well studied in model plants, the Hsf family has not been systematically investigated in heavy metal hyperaccumulators...
April 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29672568/rna-seq-transcriptome-analysis-of-amaranthus-palmeri-with-differential-tolerance-to-glufosinate-herbicide
#14
Reiofeli A Salas-Perez, Christopher A Saski, Rooksana E Noorai, Subodh K Srivastava, Amy L Lawton-Rauh, Robert L Nichols, Nilda Roma-Burgos
Amaranthus palmeri (Amaranthaceae) is a noxious weed in several agroecosystems and in some cases seriously threatens the sustainability of crop production in North America. Glyphosate-resistant Amaranthus species are widespread, prompting the use of alternatives to glyphosate such as glufosinate, in conjunction with glufosinate-resistant crop cultivars, to help control glyphosate-resistant weeds. An experiment was conducted to analyze the transcriptome of A. palmeri plants that survived exposure to 0.55 kg ha-1 glufosinate...
2018: PloS One
https://www.readbyqxmd.com/read/29672544/stress-pre-conditioning-with-temperature-uv-and-gamma-radiation-induces-tolerance-against-phosphine-toxicity
#15
Saad M Alzahrani, Paul R Ebert
Phosphine is the only general use fumigant for the protection of stored grain, though its long-term utility is threatened by the emergence of highly phosphine-resistant pests. Given this precarious situation, it is essential to identify factors, such as stress preconditioning, that interfere with the efficacy of phosphine fumigation. We used Caenorhabditis elegans as a model organism to test the effect of pre-exposure to heat and cold shock, UV and gamma irradiation on phosphine potency. Heat shock significantly increased tolerance to phosphine by 3-fold in wild-type nematodes, a process that was dependent on the master regulator of the heat shock response, HSF-1...
2018: PloS One
https://www.readbyqxmd.com/read/29671811/shape-shifted-red-blood-cells-a-novel-red-blood-cell-stage
#16
Verónica Chico, Sara Puente-Marin, Iván Nombela, Sergio Ciordia, María Carmen Mena, Begoña Carracedo, Alberto Villena, Luis Mercado, Julio Coll, María Del Mar Ortega-Villaizan
Primitive nucleated erythroid cells in the bloodstream have long been suggested to be more similar to nucleated red cells of fish, amphibians, and birds than the red cells of fetal and adult mammals. Rainbow trout Ficoll-purified red blood cells (RBCs) cultured in vitro undergo morphological changes, especially when exposed to stress, and enter a new cell stage that we have coined shape-shifted RBCs (shRBCs). We have characterized these shRBCs using transmission electron microscopy (TEM) micrographs, Wright⁻Giemsa staining, cell marker immunostaining, and transcriptomic and proteomic evaluation...
April 19, 2018: Cells
https://www.readbyqxmd.com/read/29671321/a-comparative-metabolomics-approach-detects-stress-specific-responses-during-coral-bleaching-in-soft-corals
#17
Mohamed A Farag, Achim Meyer, Sara E Ali, Mohamed A Salem, Patrick Giavalisco, Hildegard Westphal, Ludger A Wessjohann
Chronic exposure to ocean acidification and elevated sea-surface temperatures pose significant stress to marine ecosystems. This in turn necessitates costly acclimation responses in corals in both the symbiont and host, with a re-organization of cell metabolism and structure. A large-scale untargeted metabolomics approach comprising gas chromatography mass spectrometry (GC-MS) and ultra performance liquid chromatography coupled to high resolution mass spectrometry (UPLC-MS) was applied to profile the metabolite composition of the soft coral Sarcophyton ehrenbergi and its dinoflagellate symbiont...
April 19, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29671254/co-enzyme-q10-upregulates-hsp70-and-protects-chicken-primary-myocardial-cells-under-in-vitro-heat-stress-via-pkc-mapk
#18
Jiao Xu, Shu Tang, Bin Yin, Jiarui Sun, Endong Bao
In this report, we investigate the protective mechanism of co-enzyme Q10 on chicken primary myocardial cells during heat stress. Morphological observations indicate that addition of co-enzyme Q10 protects myocardial cells from heat stress, reduces the damage of mitochondria and nucleus, and decreases the mean number of vacuolated mitochondria. We have previously shown that co-enzyme Q10 can protect myocardial cells by upregulating the expression of Hsp70. Therefore, signaling pathways involved in this process were explored...
April 18, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29670282/global-warming-transforms-coral-reef-assemblages
#19
Terry P Hughes, James T Kerry, Andrew H Baird, Sean R Connolly, Andreas Dietzel, C Mark Eakin, Scott F Heron, Andrew S Hoey, Mia O Hoogenboom, Gang Liu, Michael J McWilliam, Rachel J Pears, Morgan S Pratchett, William J Skirving, Jessica S Stella, Gergely Torda
Global warming is rapidly emerging as a universal threat to ecological integrity and function, highlighting the urgent need for a better understanding of the impact of heat exposure on the resilience of ecosystems and the people who depend on them 1 . Here we show that in the aftermath of the record-breaking marine heatwave on the Great Barrier Reef in 2016 2 , corals began to die immediately on reefs where the accumulated heat exposure exceeded a critical threshold of degree heating weeks, which was 3-4 °C-weeks...
April 18, 2018: Nature
https://www.readbyqxmd.com/read/29670149/impaired-photosynthesis-and-increased-leaf-construction-costs-may-induce-floral-stress-during-episodes-of-global-warming-over-macroevolutionary-timescales
#20
Matthew Haworth, Claire M Belcher, Dilek Killi, Rebecca A Dewhirst, Alessandro Materassi, Antonio Raschi, Mauro Centritto
Global warming events have coincided with turnover of plant species at intervals in Earth history. As mean global temperatures rise, the number, frequency and duration of heat-waves will increase. Ginkgo biloba was grown under controlled climatic conditions at two different day/night temperature regimes (25/20 °C and 35/30 °C) to investigate the impact of heat stress. Photosynthetic CO2 -uptake and electron transport were reduced at the higher temperature, while rates of respiration were greater; suggesting that the carbon balance of the leaves was adversely affected...
April 18, 2018: Scientific Reports
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