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https://www.readbyqxmd.com/read/29782509/maternal-cardiovascular-and-endothelial-function-from-first-trimester-to-postpartum
#1
Vassiliki Kolovetsiou-Kreiner, Manfred Georg Moertl, Ilona Papousek, Karin Schmid-Zalaudek, Uwe Lang, Dietmar Schlembach, Mila Cervar-Zivkovic, Helmut Karl Lackner
OBJECTIVE: To explore noninvasively the complex interactions of the maternal hemodynamic system throughout pregnancy and the resulting after-effect six weeks postpartum. METHODS: Eighteen women were tested beginning at the 12th week of gestation at six time-points throughout pregnancy and six weeks postpartum. Heart rate, heart rate variability, blood pressure, pulse transit time (PTT), respiration, and baroreceptor sensitivity were analyzed in resting conditions...
2018: PloS One
https://www.readbyqxmd.com/read/29781840/cardiovascular-autonomic-profile-in-women-with-constitutional-hypotension
#2
Giris Jacob, Franca Barbic, Meytal Glago, Franca Dipaola, Alberto Porta, Raffaello Furlan
BACKGROUND: Constitutional hypotension (CHT) is defined as a SBP below 105 mmHg. As autonomic-related symptoms are frequently reported in CHT, these symptoms suggest that the cardiovascular autonomic control is perturbed in individuals with CHT. METHODS: We investigated the autonomic cardiovascular control of 15 women with CHT and 12 women with NBP (SBP >110 mmHg). We monitored BP and ECG for autonomic function test. Supine and head up tilt (HUT) spectral analysis of RR interval and BP variability, baroreflex sensitivity and plasma levels of plasma renin activity and aldosterone were determined...
May 16, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29778242/cardiovascular-responses-to-isometric-handgrip-exercise-in-young-patients-with-recurrent-vasovagal-syncope
#3
Juan Idiaquez, Juan Francisco Idiaquez, Rodrigo Iturriaga
OBJECTIVE: Arterial blood pressure (BP) increased in healthy humans in response to isometric handgrip (IHG), but the pattern of the relative contribution of cardiac output (CO) and total peripheral resistance (TPR) changes to the pressor response is different among individuals. We investigated weather patients with recurrent vasovagal syncope (VVS) have a similar pattern of individual CO, TPR and pressor responses to IHG, as healthy subjects. METHODS: 32 patients (27...
July 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29775234/effects-of-whole-body-vibration-on-heart-rate-variability-acute-responses-and-training-adaptations
#4
REVIEW
Alexei Wong, Arturo Figueroa
Heart rate variability (HRV) is a noninvasive and practical measure of cardiac autonomic nervous system function, mainly the sympathetic and parasympathetic modulations of heart rate. A low HRV has been shown to be indicative of compromised cardiovascular health. Interventions that enhance HRV are therefore beneficial to cardiovascular health. Whole-body vibration (WBV) training has been proposed as an alternative time-efficient exercise intervention for the improvement of cardiovascular health. In this review, we discuss the effect of WBV both acute and after training on HRV...
May 18, 2018: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29763765/towards-understanding-the-complexity-of-cardiovascular-oscillations-insights-from-information-theory
#5
Michal Javorka, Jana Krohova, Barbora Czippelova, Zuzana Turianikova, Zuzana Lazarova, Radovan Wiszt, Luca Faes
Cardiovascular complexity is a feature of healthy physiological regulation, which stems from the simultaneous activity of several cardiovascular reflexes and other non-reflex physiological mechanisms. It is manifested in the rich dynamics characterizing the spontaneous heart rate and blood pressure variability (HRV and BPV). The present study faces the challenge of disclosing the origin of short-term HRV and BPV from the statistical perspective offered by information theory. To dissect the physiological mechanisms giving rise to cardiovascular complexity in different conditions, measures of predictive information, information storage, information transfer and information modification were applied to the beat-to-beat variability of heart period (HP), systolic arterial pressure (SAP) and respiratory volume signal recorded non-invasively in 61 healthy young subjects at supine rest and during head-up tilt (HUT) and mental arithmetics (MA)...
May 5, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29755228/effect-of-1-week-yoga-based-residential-program-on-cardiovascular-variables-of-hypertensive-patients-a-comparative-study
#6
Kashinath G Metri, Balaram Pradhan, Amit Singh, H R Nagendra
Introduction: Hypertension (HTN) is an important public health concern and a leading cause of morbidity and mortality worldwide. Yoga is a form of mind-body medicine shown to be effective in controlling blood pressure (BP) and reduces cardiac risk factors in HTN. Integrated approach of Yoga therapy (IAYT) is a residential yoga-based lifestyle intervention proven to be beneficial in several health conditions. Aim: To study the efficacy of 1 week of residential IAYT intervention on cardiovascular parameters in hypertensive patients...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29745800/interaction-between-graviception-and-carotid-baroreflex-function-in-humans-during-parabolic-flight-induced-microgravity
#7
Shigehiko Ogoh, Michaël Marais, Romain Lericollais, Pierre Denise, Peter B Raven, Hervé Normand
The aim of the present study was to assess carotid baroreflex (CBR) during acute changes in otolithic activity in humans. To address this question, we designed a set of experiments to identify the modulatory effects of microgravity on CBR function at a tilt angle of -2{degree sign}, which was identified to minimize changes in central blood volume during parabolic flight. During parabolic flight at 0g and 1g, CBR function curves were modelled from the heart rate (HR) and mean arterial pressure (MAP) responses to rapid pulse trains of neck pressure (NP) and neck suction (NS) ranging from +40 to -80 Torr; CBR control of HR (carotid-HR) and MAP (carotid-MAP) baroreflex function curves, respectively...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29744599/endovascular-baroreflex-amplification-for-resistant-hypertension
#8
REVIEW
Monique E A M van Kleef, Mark C Bates, Wilko Spiering
PURPOSE OF REVIEW: Most hypertension devices have been designed to interrupt or modify the sympathetic nervous system, which seems to be unbalanced in hypertension. Carotid baroreceptors play a pivotal role in maintaining adrenergic balance via a direct feedback interface and would be an exceptional target for intervention. The purpose of this review is to define the role of the baroreceptor in hypertension, to examine device-based therapies targeting the baroreflex and to explore future promises of endovascular baroreflex amplification (EBA)...
May 9, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29744528/device-therapy-in-heart-failure-with-reduced-ejection-fraction-cardiac-resynchronization-therapy-and-more
#9
D Duncker, C Veltmann
In patients with heart failure with reduced ejection fraction (HFrEF), optimal medical treatment includes beta-blockers, ACE inhibitors/angiotensinreceptor-neprilysin inhibitors (ARNI), mineralocorticoid receptor antagonists, and ivabradine when indicated. In device therapy of HFrEF, implantable cardioverter-defibrillators and cardiac resynchronization therapy (CRT) have been established for many years. CRT is the therapy of choice (class I indication) in symptomatic patients with HFrEF and a broad QRS complex with a left bundle branch block (LBBB) morphology...
May 9, 2018: Herz
https://www.readbyqxmd.com/read/29740334/autonomic-differentiation-map-a-novel-statistical-tool-for-interpretation-of-heart-rate-variability
#10
Daniela Lucini, Nadia Solaro, Massimo Pagani
In spite of the large body of evidence suggesting Heart Rate Variability (HRV) alone or combined with blood pressure variability (providing an estimate of baroreflex gain) as a useful technique to assess the autonomic regulation of the cardiovascular system, there is still an ongoing debate about methodology, interpretation, and clinical applications. In the present investigation, we hypothesize that non-parametric and multivariate exploratory statistical manipulation of HRV data could provide a novel informational tool useful to differentiate normal controls from clinical groups, such as athletes, or subjects affected by obesity, hypertension, or stress...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29726017/effect-of-cerebral-flow-autoregulation-function-on-cerebral-flow-rate-under-continuous-flow-left-ventricular-assist-device-support
#11
Selim Bozkurt
Neurological complications in continuous flow left ventricular assist device (CF-LVAD) patients are the second-leading risk of death after multi-organ failure. They are associated with altered blood flow in the cardiovascular system because of CF-LVAD support. Moreover, an impaired cerebral autoregulation function may also contribute to complications such as hyperperfusion in the cerebral circulation under mechanical circulatory support. The aim of this study is to evaluate the effect of cerebral autoregulatory function on cerebral blood flow rate under CF-LVAD support...
May 3, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29723261/microvolt-t-wave-alternans-and-autonomic-nervous-system-parameters-can-be-helpful-in-the-identification-of-low-arrhythmic-risk-patients-with-ischemic-left-ventricular-systolic-dysfunction
#12
Ludmiła Daniłowicz-Szymanowicz, Damian Kaufmann, Katarzyna Rozwadowska, Maciej Kempa, Ewa Lewicka, Grzegorz Raczak
INTRODUCTION: The role of implantable cardioverter-defibrillator (ICD) placement in the primary prevention of sudden cardiac death (SCD) in all consecutive patients with left ventricular ejection fraction (LVEF) ≤ 35% is still a matter of hot debate due to the fact that the population of these patients is highly heterogeneous in terms of the SCD risk. Nevertheless, reduced LVEF is still the only established criterion during qualification of patients for ICD implantation in the primary prevention of SCD, therefore identification of persons with particularly high risk among patients with LVEF ≤35% is currently of lesser importance...
2018: PloS One
https://www.readbyqxmd.com/read/29718876/effects-of-slow-breathing-rate-on-heart-rate-variability-and-arterial-baroreflex-sensitivity-in-essential-hypertension
#13
Changjun Li, Qinghua Chang, Jia Zhang, Wenshu Chai
This study is to investigate the effects of slow breathing on heart rate variability (HRV) and arterial baroreflex sensitivity in essential hypertension.We studied 60 patients with essential hypertension and 60 healthy controls. All subjects underwent controlled breathing at 8 and 16 breaths per minute. Electrocardiogram, respiratory, and blood pressure signals were recorded simultaneously. We studied effects of slow breathing on heart rate, blood pressure and respiratory peak, high-frequency (HF) power, low-frequency (LF) power, and LF/HF ratio of HRV with traditional and corrected spectral analysis...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29713800/effect-of-flunitrazepam-as-an-oral-hypnotic-on-24-hour-blood-pressure-in-healthy-volunteers
#14
Daniele Bosone, Roberto Fogari, Annalisa Zoppi, Angela D'Angelo, Natascia Ghiotto, Giulia Perini, Matteo Cotta Ramusino, Alfredo Costa
PURPOSE: The present study was carried out in order to assess the effects of chronic administration of flunitrazepam (as an oral hypnotic) on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. MATERIALS AND METHODS: Following a 2-week placebo run-in period, 28 healthy volunteers (13 males and 15 females) between 21 and 30 years were randomized to receive either flunitrazepam 1 mg or placebo (both administered once a day in the evening) for 4 weeks in two cross-over periods; each separated by a 2-week placebo period...
April 30, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29705650/baroreflex-activation-therapy-for-the-treatment-of-heart-failure-with-reduced-ejection-fraction-in-patients-with-and-without-coronary-artery-disease
#15
Marcel Halbach, William T Abraham, Christian Butter, Anique Ducharme, Didier Klug, William C Little, Hannes Reuter, Jill E Schafer, Michele Senni, Vijay Swarup, Rolf Wachter, Fred A Weaver, Seth J Wilks, Michael R Zile, Jochen Müller-Ehmsen
BACKGROUND: In a randomized trial, baroreflex activation therapy (BAT) improved exercise capacity, quality of life and NT-proBNP in patients with heart failure with reduced ejection fraction (HFrEF). In view of different mechanisms underlying HFrEF, we performed a post-hoc subgroup analysis of efficacy and safety of BAT in patients with and without coronary artery disease (CAD). METHODS AND RESULTS: Patients with left ventricular ejection fraction <35% and NYHA Class III were randomized 1:1 to guideline-directed medical and device therapy alone or plus BAT...
April 21, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29701999/mechanisms-underlying-the-increased-cardiac-norepinephrine-spillover-in-heart-failure
#16
Rohit Ramchandra, Sally Hood, Daniel Xing, Gavin Lambert, Clive May
Patients with heart failure (HF) have increased levels of cardiac norepinephrine (NE) spillover, which is an independent predictor of mortality. We hypothesized that this increase in NE spillover in HF depends not only on increases in sympathetic nerve activity (SNA), but also on changes in the mechanisms controlling NE release and re-uptake. Such changes would lead to differences between the increases in directly recorded SNA and NE spillover to the heart in HF. Experiments were conducted in conscious sheep implanted with electrodes to record cardiac SNA (CSNA)...
April 27, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29700488/diagnosis-and-management-of-resistant-hypertension-state-of-the-art
#17
REVIEW
Fang-Fei Wei, Zhen-Yu Zhang, Qi-Fang Huang, Jan A Staessen
Resistant hypertension is defined as a lack of ambulatory blood pressure response to optimized medical treatment after exclusion of secondary hypertension in patients who are fully adherent to antihypertensive therapy. Patients with resistant hypertension are at high risk of complications, particularly cardiovascular events, and optimization of medical treatment remains the cornerstone of their management. Such optimization should be based on simple algorithms and include the use of aldosterone antagonists...
April 26, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29688913/the-possible-ameliorative-effect-of-ivabradine-on-the-autonomic-and-left-ventricular-dysfunction-induced-by-doxorubicin-in-male-rats
#18
Amany E El-Naggar, Sahar M El-Gowilly, Fouad M Sharabi
Heart failure is a common adverse effect associated with doxorubicin treatment. The aim of this study is to investigate the effect of ivabradine treatment on doxorubicin-induced heart failure in conscious rats. Rats were treated with doxorubicin (2.5 mg/kg/day) or ivabradine (10 mg/kg/day) alone or along with doxorubicin injections. Changes in heart rate variability (HRV), baroreflex sensitivity, left ventricular function, serum cardiac troponin T and cardiac histological features were taken as index parameters for the development of heart failure...
April 20, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29687617/noninvasive-assessment-of-autonomic-function-in-human-neonates-born-at-the-extremes-of-fetal-growth-spectrum
#19
Hasthi U Dissanayake, Rowena L McMullan, Adrienne Gordon, Ian D Caterson, David S Celermajer, Melinda Phang, Camille Raynes-Greenow, Michael R Skilton, Jaimie W Polson
Birth weight is associated with adult cardiovascular disease, such that those at both ends of the spectrum are at increased risk. This may be driven in part by modification to autonomic control, a mechanistic contributor to hypertension. However, birth weight is a relatively crude surrogate of fetal growth; and newborn body composition may more accurately identify the "at risk" infant. Accordingly, we sought to determine whether newborns with high or low body fat have altered autonomic control of vasomotor function and cardiac contractility...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29686011/direct-recording-of-cardiac-and-renal-sympathetic-nerve-activity-shows-differential-control-in-renovascular-hypertension
#20
Tycho R Tromp, Darvina Mahesh, Jaap A Joles, Rohit Ramchandra
There is increasing evidence that hypertension is initiated and maintained by elevated sympathetic tone. Increased sympathetic drive to the heart is linked to cardiac hypertrophy in hypertension and worsens prognosis. However, cardiac sympathetic nerve activity (SNA) has not previously been directly recorded in hypertension. We hypothesized that directly recorded cardiac SNA levels would be elevated during hypertension and that baroreflex control of cardiac SNA would be impaired during hypertension. Adult ewes either underwent unilateral renal artery clipping (n=12) or sham surgery (n=15)...
April 23, 2018: Hypertension
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