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Intra-articular injection

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https://www.readbyqxmd.com/read/29134408/glucosamine-reduces-the-inhibition-of-proteoglycan-metabolism-caused-by-local-anaesthetic-solution-in-human-articular-cartilage-an-in-vitro-study
#1
Abhinav Gulihar, Shalin Shaunak, Pinelopi Linardatou Novak, Parthiban Vinayakam, Baljinder Dhinsa, Grahame Taylor
BACKGROUND: We assessed whether local anaesthetics caused inhibition of proteoglycan metabolism in human articular cartilage and whether the addition of Glucosamine sulphate could prevent or allow recovery from this adverse effect on articular cartilage metabolism. METHODS: Cartilage explants obtained from 13 femoral heads from fracture neck of femur patients (average age 80 years, 10 female) were exposed to either 1% Lidocaine, 2% Lidocaine, 0.25% Bupivacaine, 0...
November 13, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29134405/cell-type-specific-gene-expression-patterns-in-the-knee-cartilage-in-an-osteoarthritis-rat-model
#2
Michal Korostynski, Natalia Malek, Marcin Piechota, Katarzyna Starowicz
Osteoarthritis (OA) is a chronic degenerative disease that leads to joint failure, pain, and disability. Gene regulation is implicated as a driver of the imbalance between the expression of catabolic and anabolic factors that eventually leads to the degeneration of osteoarthritic cartilage. In our model, knee-joint OA was induced in male Wistar rats by intra-articular sodium monoiodoacetate (MIA) injections. Whole-genome microarrays were used to analyse the alterations in gene expression during the time-course of OA development (at 2, 14, and 28 days post-injection) in rat knee joints...
November 13, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29132341/can-hybrid-hyaluronic-acid-represent-a-valid-approach-to-treat-rizoarthrosis-a-retrospective-comparative-study
#3
Sara Tenti, Nicola Antonio Pascarelli, Stefano Giannotti, Mauro Galeazzi, Nicola Giordano, Antonella Fioravanti
BACKGROUND: Osteoarthritis (OA) of the trapeziometacarpal joint (TMJ) is a disabling condition with a significant impact on quality of life. The optimal management of hand OA requires a combination of non-pharmacological and pharmacological treatments that include intra-articular (i.a.) therapy. EULAR experts recommend corticosteroid injections in TMJ OA and underline the usefulness of hyaluronic acid (HA). The aim of this study was the assessment of the efficacy and tolerability of i...
November 13, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29129326/risk-factors-and-clinical-characteristics-of-deep-knee-infection-in-patients-with-intra-articular-injections-a-matched-retrospective-cohort-analysis
#4
Chi Xu, Haiwen Peng, Rui Li, Wei Chai, Xiang Li, Jun Fu, Kan Liu, Baozhan Yu, Chengqi Jia, Jiying Chen
BACKGROUND: Deep knee infection (DKI), consisting of sepsis arthritis (SA) and chronic low-grade infection (CLGI), is a rare but catastrophic adverse event that can result from intra-articular (IA) injections. The purpose of this study was to assess the risk factors for DKI and describe the clinical characteristics of DKI in patients who received IA injections. METHODS: Fifty patients with IA injection-induced DKI who underwent surgical treatment between January 2010 and May 2016 served as cases and were matched with non-infected controls who received IA injections in a proportion of 1:5 based on age, gender, and date of admission...
October 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29126382/analysis-of-medical-service-use-of-knee-osteoarthritis-and-knee-meniscal-and-ligament-injuries-in-korea-a-cross-sectional-study-of-national-patient-sample-data
#5
Chang Yong Suh, Yoon Jae Lee, Joon-Shik Shin, Jinho Lee, Me-Riong Kim, Wonil Koh, Yun-Yeop Cha, Byung-Cheul Shin, Eui-Hyoung Hwang, Kristin Suhr, Mia Kim, In-Hyuk Ha
BACKGROUND: Osteoarthritis (OA) and meniscal and ligament injuries of the knee are the two most common knee disorders in Korea. The aim of this study was to analyze the demographic characteristics, medical service use and related costs for these disorders, and the results are expected to help inform practitioners, researchers, and policy-makers. METHODS: The present study aimed to evaluate incidence and patient characteristics, and to assess current medical service use, usual care, and medical expenses of knee disorders by analyzing 2014 national patient sample data from the Korean Health Insurance Review and Assessment Service...
November 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29120821/an-injectable-electrostatically-interacting-drug-depot-for-the-treatment-of-rheumatoid-arthritis
#6
Ji Hoon Park, Seung Hun Park, Hye Yun Lee, Jin Woo Lee, Bo Keun Lee, Bun Yeoul Lee, Jae Ho Kim, Moon Suk Kim
To the best of our knowledge, no studies have yet examined the electrostatic interaction of polyelectrolytes with electrolyte drugs for the treatment of rheumatoid arthritis (RA). Here, an injectable, electrostatically interacting drug depot is described. We prepared methoxy polyethylene glycol-b-poly(ε-caprolactone)-ran-poly(l-lactic acid) (MC) diblock copolymers with a carboxylic acid group (MC-C) at the pendant position. MC-C was polyelectrolytes that exhibited negative zeta potentials. Sulfasalazine [Sul(-)] and minocycline [Min(+)], electrolyte RA drugs, exhibited negative and positive zeta potentials, respectively...
November 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/29118985/acute-development-of-cushing-syndrome-in-an-hiv-infected-child-on-atazanavir-ritonavir-based-antiretroviral-therapy
#7
Gueorgui Dubrocq, Andrea Estrada, Shannon Kelly, Natella Rakhmanina
An 11-year-old male with perinatally acquired human immune deficiency virus (HIV) infection on antiretroviral regimen, which included abacavir plus lamivudine (Epzicom), didanosine, ritonavir and atazanavir presented with bilateral axillary striae, increased appetite, fatigue, facial swelling and acute weight gain. Two months prior to presentation, the patient had received a diagnostic and therapeutic intra-articular triamcinolone injection in the knee for pain relief and subsequently became progressively swollen in the face, developed striae bilaterally at the axillae, experienced increased appetite, fatigue and an 8 pound weight gain...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29114635/early-efficacy-of-intra-articular-hyadd%C3%A2-4-hymovis%C3%A2-injections-for-symptomatic-knee-osteoarthritis
#8
Ferdinando Priano
Purpose  The aim of the study was to evaluate the clinical effects of HYADD® 4, an hydrogel based on a hyaluronic acid derivative, in patients with symptomatic knee osteoarthritis, on symptoms, and joint function. Methods  This retrospective study of patients with Kellgren-Lawrence grade II to IV knee osteoarthritis (American College of Rheumatology criteria) enrolled patients who had received two infiltrations of HYADD® 4, (24 mg/3 mL) 1 week apart, and evaluated: pain at rest, pain with movement, change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score; change in nonsteroidal anti-inflammatory drugs (NSAIDs)/acetaminophen use; satisfaction with therapy; tolerability...
June 2017: Joints
https://www.readbyqxmd.com/read/29114622/single-platelet-rich-plasma-injection-for-early-stage-of-osteoarthritis-of-the-knee
#9
Liborio Ingala Martini, Alessio Giai Via, Chiara Fossati, Filippo Randelli, Pietro Randelli, Davide Cucchi
Purpose  The purpose of this study was to determine the safety efficacy and outcomes of platelet-rich plasma (PRP) intra-articular injections for early stages of knee osteoarthritis (OA). Methods  Twenty-five patients affected by grade I and II knee primary OA according to the Kellgren-Lawrence scale received a single intra-articular PRP injection. Patients were prospectively evaluated for 6 months. Visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee injury and Osteoarthritis Outcome Score (KOOS) scoring scales were used to evaluate clinical outcomes...
March 2017: Joints
https://www.readbyqxmd.com/read/29108480/short-term-homing-of-hyaluronan-primed-cells-therapeutic-implications-for-osteoarthritis-treatment
#10
Giovanna Desando, Isabella Bartolotti, Carola Cavallo, Antonella Schiavinato, Cynthia Secchieri, Elizaveta Kon, Giuseppe Filardo, Maurizio Paro, Brunella Grigolo
The evaluation of key factors modulating cell homing following transplantation can provide new insights in the comprehension of unsolved biological questions about the use of cell therapies for osteoarthritis (OA). The main purpose of this in vivo study was to investigate the biodistribution of an intra-articular (IA) injection of mesenchymal stromal cells (MSCs) and bone marrow concentrate (BMC) in a rabbit OA model, and whether the additional use of sodium hyaluronate (HA) could modulate their migration and promote joint repair...
November 6, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29100773/predictors-of-clinically-suspected-intra-articular-hip-symptoms-and-prevalence-of-hip-pathomorphologies-presenting-to-sports-medicine-and-hip-preservation-orthopaedic-surgeons
#11
Christopher M Larson, Marc R Safran, David A Brcka, Zackary D Vaughn, M Russell Giveans, Rebecca M Stone
PURPOSE: The first purpose of the study was to evaluate the prevalence of various radiographic parameters and pathomorphologies for patients presenting with the diagnosis of hip pain. The second purpose of this study was to identify those pathomorphologies and radiographic parameters that were predictive of clinically suspected intra-articular and hip joint-related symptoms. METHODS: A total of 998 hips (499 patients, 228 males, 271 females, mean age 38 years) presented to 2 orthopaedic surgeons with the diagnosis of hip pain...
October 31, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29098135/antidote-or-poison-a-case-of-anaphylactic-shock-after-intra-articular-corticosteroid-injection
#12
Pooja Sethi, Jennifer Treece, Chidinma Onweni, Vandana Pai
Although glucocorticoids are often used as an adjunct to epinephrine to treat anaphylactic shock, glucocorticoids can also be a rare cause of anaphylactic shock. Only through the administration of a challenge dose of different glucocorticoids and different substrates that glucocorticoids are delivered in can the determination be made about which glucocorticoid or accompanying solvent may be the culprit which caused the anaphylactic reaction. These challenge tests should only be performed in a controlled environment as repeat anaphylaxis is a risk, especially if the patient has a history of glucocorticoid-induced anaphylaxis...
August 29, 2017: Curēus
https://www.readbyqxmd.com/read/29095245/prospective-multicenter-randomized-crossover-clinical-trial-comparing-the-safety-and-effectiveness-of-cooled-radiofrequency-ablation-with-corticosteroid-injection-in-the-management-of-knee-pain-from-osteoarthritis
#13
Tim Davis, Eric Loudermilk, Michael DePalma, Corey Hunter, David Lindley, Nilesh Patel, Daniel Choi, Marc Soloman, Anita Gupta, Mehul Desai, Asokumar Buvanendran, Leonardo Kapural
BACKGROUND AND OBJECTIVES: Osteoarthritis (OA) of the knee affects the aging population and has an associated influence on the health care system. Rigorous studies evaluating radiofrequency ablation for OA-related knee pain are lacking. This study compared long-term clinical safety and effectiveness of cooled radiofrequency ablation (CRFA) with intra-articular steroid (IAS) injection in managing OA-related knee pain. METHODS: This is a prospective, multicenter, randomized trial with 151 subjects with chronic (≥6 months) knee pain that was unresponsive to conservative modalities...
November 1, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29094212/review-of-diabetic-frozen-shoulder
#14
REVIEW
C Whelton, C A Peach
Frozen shoulder is a painful debilitating condition which can be diagnosed clinically. It is a condition of chronic inflammation and proliferative fibrosis resulting in painful limitation of shoulder movements with classical clinical signs. Diabetic patients are more likely to develop the disease and more likely to require operative management. Diabetic frozen shoulder is a difficult condition to manage, and the clinician must strike a balance between improving range of movement and treating pain, but not over-treating what is an essentially self-resolving condition...
November 1, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29093340/intra-articular-retention-and-anti-arthritic-effects-in-collagen-induced-arthritis-model-mice-by-injectable-small-interfering-rna-containing-hydrogel
#15
Takanori Kanazawa, Kuniko Tamano, Kana Sogabe, Takahiro Endo, Hisako Ibaraki, Yuuki Takashima, Yasuo Seta
Small interfering RNAs (siRNAs) are expected to offer a means of treating rheumatoid arthritis (RA) because they allow the specific silencing of genes related to RA pathogenesis. In our previous study, we reported that the siRNA targeted against RelA (anti-RelA siRNA), an important nuclear factor-kappaB (NF-κB) subdomain, was an effective therapeutic in atopic dermatitis and RA model animals. In this study, to develop an intra-articular injectable gel formulation against RA, we prepared a hydrogel that contains anti-RelA siRNA, and determined the in vitro release profile (%) and in vivo intra-articular retention of fluorescence-labeled model siRNA, and the anti-arthritic effects of the anti-RelA siRelA containing hydrogel in RA model mice...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29081706/compared-efficacy-of-intra-articular-injection-of-methylprednisolone-and-triamcinolone
#16
Abdul Fettah Buyuk, Eray Kilinc, Ismet Yalkin Camurcu, Savas Camur, Hanifi Ucpunar, Adnan Kara
OBJECTIVE: To compare the effect of two different corticosteroid types in bilateral and symmetrical knee osteoarthritis (OA). METHODS: One hundred and twenty-six patients received injections of methylprednisolone acetate (MP) in one knee and triamcinolone hexacetonide (TH) in the contralateral knee. Patients were evaluated before injection and 2, 4, 8, 12, and 24 weeks after. RESULTS: Mean patient age was 68.5±9 years. Mean BMI was 26.3±2...
September 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/29075136/outcomes-of-c1-2-joint-injections
#17
Christopher M Aiudi, W Michael Hooten, Rebecca A Sanders, James C Watson, Susan M Moeschler, Halena M Gazelka, Bryan C Hoelzer, Jason S Eldrige, Wenchun Qu, Tim J Lamer
OBJECTIVE: Intra-articular injections of the C1-2 joint are an effective therapeutic option for pain generated from degenerative and inflammatory conditions affecting the joint. Limited information exists about the adverse events (AEs) associated with these injections. The primary aim of this study is to describe the frequency and type of AEs associated with C1-2 joint injections. The secondary aim is to identify clinical factors associated with the occurrence of AEs of C1-2 joint injections...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29073792/alendronate-loaded-biodegradable-smart-hydrogel-a-promising-injectable-depot-formulation-for-osteoporosis
#18
Noha Nafee, Mariam Zewail, Nabila Boraie
Alendronate (ALN) is a BCS III bone resorption inhibitor, with very poor oral bioavailability. Our approach is to develop a minimally invasive thermogelling system for prolonged local delivery of ALN. For this, different chitosan-based thermogels were developed and characterised in terms of gelation time, injectability, pH, viscosity and thermoreversibility. Chitosan/β-glycerophosphate (CS/βGP) hydrogel pursued temperature-dependent, thermoreversible gelation behaviour and was thus selected for drug loading...
October 26, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29072705/microrna-145-attenuates-tnf-%C3%AE-driven-cartilage-matrix-degradation-in-osteoarthritis-via-direct-suppression-of-mkk4
#19
Guoli Hu, Xiaoying Zhao, Chuandong Wang, Yiyun Geng, Jingyu Zhao, Jiajia Xu, Bin Zuo, Chen Zhao, Chenglong Wang, Xiaoling Zhang
Cartilage dyshomeostasis contributes to osteoarthritis (OA) pathogenesis, and tumor necrosis factor (TNF)-α has critical role in this process by driving inflammatory cascades and cartilage degradation. However, the negative regulation of TNF-α-mediated signaling remains undefined. Here we demonstrate the crucial role of miR-145 in the modulation of TNF-α-mediated signaling and cartilage matrix degradation. MicroRNA (miRNA) expression profiles of TNF-α-stimulated chondrocytes showed that miR-145 expression was rapidly downregulated by TNF-α...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29068480/phlpp-inhibitors-block-pain-and-cartilage-degradation-associated-with-osteoarthritis
#20
Soyun M Hwang, Marina Feigenson, Dana L Begun, Lomeli Carpio Shull, Kirsty L Culley, Miguel Otero, Mary B Goldring, Lauren E Ta, Sanjeev Kakar, Elizabeth W Bradley, Jennifer J Westendorf
Phlpp protein phosphatases are abnormally abundant within human osteoarthritic articular chondrocytes and may contribute to the development of osteoarthritis. Mice lacking Phlpp1 were previously shown to be resistant to post-traumatic osteoarthritis. Here a small molecule with therapeutic properties that inhibits Phlpp1 and Phlpp2 was tested for its ability to slow post-traumatic OA in mice and to stimulate anabolic pathways in human articular cartilage from OA joints. PTOA was induced in male C57Bl/6 mice by surgically destabilizing the meniscus...
October 25, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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