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https://www.readbyqxmd.com/read/27231174/associations-of-human-leukocyte-antigen-drb1-alleles-with-nasopharyngeal-carcinoma-and-its-clinical-significance-in-xinjiang-uyghur-autonomous-region-of-china
#1
Xiao-Tao Geng, Yun-Hui Hu, Tao Dong, Ruo-Zheng Wang
BACKGROUND: Genetic susceptibility is one of the major etiological factors for nasopharyngeal carcinoma (NPC). Among the genetic predisposing factors, human leukocyte antigen (HLA) genes have been reported to be associated with NPC. This study aimed to investigate the associations of HLA-DRB1 alleles with NPC and the clinical significance of HLA-DRB1 alleles in NPC. METHODS: From January 2009 to December 2013, 140 NPC patients (118 Han patients and 22 Uyghur patients) and 158 healthy controls (81 Han individuals and 77 Uyghur individuals) from Xinjiang Province were genotyped for HLA-DRB1 using the polymerase chain reaction-sequence specific primer technique...
June 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/26097834/hla-class-ii-alleles-in-romanian-patients-with-chronic-hepatitis-c
#2
Loredana Gheorghe, Sorin Rugină, Irina Magdalena Dumitru, Irina Franciuc, Alina Martinescu, Iulia Balaş
INTRODUCTION: The objective of the study was to determine the association of host human leukocyte antigen (HLA) class II genotype DRB1 alleles with the response to interferon therapy, viral loads and extent of liver fibrosis in a group of Romanian patients diagnosed with chronic hepatitis C, with different clinical outcomes. Class II HLA genes, particularly the HLA-DRB1 and DQB1 genes, have been shown to have an important role in self-limiting or persistent viral infection, in different genetic populations...
June 2015: Germs
https://www.readbyqxmd.com/read/25706099/in-silico-analysis-for-structure-function-and-t-cell-epitopes-of-a-hypothetical-conserved-hp-c-protein-coded-by-pvx_092425-in-plasmodium-vivax
#3
Jinyu Mo, Jian Li
OBJECTIVE: Plasmodium spp. merozoite glycosylphosphatidylinositol-anchored proteins (GPI-APs) considered as protective immunogen in novel vaccines against malaria. To analyze the structure and function of a hypothetical conserved (HP-C) GPI-AP coded by gene PVX_092425 from Plasmodium vivax, and find its potential T-cell epitopes for further vivax malaria vaccine study. METHODS: The structure, function and T-cell epitopes of the HP-C protein named Pvx_092425 were analyzed and predicted by online and offline bioinformatics software...
March 2015: Pathogens and Global Health
https://www.readbyqxmd.com/read/23275687/selection-of-epitope-based-vaccine-targets-of-hcv-genotype-1-of-asian-origin-a-systematic-in-silico-approach
#4
Abida Shehzadi, Shahid Ur Rehman, Tayyab Husnain
UNLABELLED: Hepatitis C is the major health problem over the globe affecting approximately 200 million people worldwide and about 10 million Pakistani populations. Developing countries are especially facing the problems of HCV infection. Hence the goal of the study was to find out the antigenic epitopes that could be effective vaccine targets of HCV genotype 1 of Asian origin against HLA alleles frequently distributed in Asian countries. A total of 85 complete genome sequences of HCV 1 of Asian origin were retrieved from the HCV sequence database...
2012: Bioinformation
https://www.readbyqxmd.com/read/22874112/drug-induced-tinu-syndrome-and-genetic-characterization
#5
Domenico Santoro, Giuseppe Vita, Stefania Rovito, Lucia Venuto, Vittorio Cavallari, Roberto Vita, Vincenzo Savica, Guido Bellinghieri, Sebastiano Gangemi
Tubulointerstitial nephritis and uveitis (TINU) syndrome is due to a disregulation of cell-mediated immunity and genetical predisposition due a particular molecular characterization. We report the case of a 50-year-old woman who was admitted for acute renal failure. She had recently taken flurbiprofen for 10 d for recurrent bronchitis. A renal biopsy revealed acute tubulointerstitial nephritis. Prednisone was started and prognosis was favorable. Three months later the patient developed transitory blurred vision...
September 2012: Clinical Nephrology
https://www.readbyqxmd.com/read/22723331/genetic-determinants-of-21-hydroxylase-autoantibodies-amongst-patients-of-the-type-1-diabetes-genetics-consortium
#6
Peter Baker, Pam Fain, Heinrich Kahles, Liping Yu, John Hutton, Janet Wenzlau, Marian Rewers, Klaus Badenhoop, George Eisenbarth
BACKGROUND: Autoantibodies to 21-hydroxylase (21OH-AA) precede the onset of autoimmune Addison's disease (AD) and are found in 1.5% of individuals with type 1 diabetes mellitus (T1DM). The greatest genetic risk for both disorders is found in the major histocompatibility complex (MHC), suggesting a common pathophysiology between AD and T1DM. Screening for 21OH-AA in newly diagnosed T1DM patients is a valuable prognostic tool, made stronger when MHC genotype is considered. METHODS: The Type 1 Diabetes Genetics Consortium has collected genotype data in T1DM subjects with tissue-specific autoantibody typing...
August 2012: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/21630107/a-peptide-epitope-derived-from-the-cancer-testis-antigen-hom-mel-40-ssx2-capable-of-inducing-cd4%C3%A2-%C2%BA-and-cd8%C3%A2-%C2%BA-t-cell-as-well-as-b-cell-responses
#7
Frank Neumann, Boris Kubuschok, Kubilay Ertan, Claudia Schormann, Stefan Stevanovic, Klaus-Dieter Preuss, Werner Schmidt, Michael Pfreundschuh
BACKGROUND: Antigen-derived HLA class I-restricted peptides can generate specific CD8(+) T-cell responses in vivo and are therefore often used as vaccines for patients with cancer. However, only occasional objective clinical responses have been reported suggesting the necessity of CD4(+) T-cell help and possibly antibodies for the induction of an effective anti-tumor immunity in vivo. The SSX2 gene encodes the cancer testis antigen (CTA) HOM-MEL-40/SSX2, which is frequently expressed in a wide spectrum of cancers...
September 2011: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/20492596/distribution-of-kir-genes-in-the-population-of-unrelated-individuals-homozygous-for-ancestral-haplotype-ah8-1-hla-a1b8dr3
#8
P Jindra, P Venigová, D Lysák, K Steinerova, V Koza
Despite the independent segregation of genes encoding killer immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA), there is some evidence of some kind of co-evolution. Therefore, one could expect reduced KIR diversity within the HLA restricted population. A total of 41 unrelated individuals homozygous for ancestral HLA haplotype AH8.1 (HLA-A*0101-Cw*0701-B*0801-DRB1*0301-DQB1*0201) were genotyped for KIRs. Over all, 14 different genotypes were identified. The KIR genes and genotypes repertoire generally mirror the published frequencies in Caucasians...
September 2010: Tissue Antigens
https://www.readbyqxmd.com/read/20207784/influence-of-hla-drb1-allele-heterogeneity-on-disease-risk-and-clinical-course-in-a-west-australian-ms-cohort-a-high-resolution-genotyping-study
#9
Jing-Shan Wu, Ian James, Wei Qiu, Alison Castley, Frank T Christiansen, William M Carroll, Frank L Mastaglia, Allan G Kermode
BACKGROUND: Previous studies on the influence of HLA-DRB1 alleles on multiple sclerosis (MS) susceptibility and clinical course have mostly employed the 2-point genotyping method. OBJECTIVE: To assess the influence of HLA-DRB1 alleles and allele interactions on disease risk and clinical course in a large West Australian MS patient cohort using high-resolution genotyping. METHODS: Four digit HLA-DRB1 genotyping was performed on a group of 466 clinically definite or probable MS patients from the Perth Demyelinating Diseases Database and 189 healthy Caucasian controls from the Busselton Community Health Study...
May 2010: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/19756183/hla-drb1-among-patients-with-vogt-koyanagi-harada-disease-in-saudi-arabia
#10
Alia Iqniebi, Ameera Gaafar, Atia Sheereen, Abdullah Al-Suliman, Gamal Mohamed, Khaled Al-Hussein, Khalid F Tabbara
PURPOSE: Vogt-Koyanagi-Harada (VKH) disease is an immune-mediated disorder with autoimmune insult directed against antigens associated with melanocytes. The genetic predisposition among VKH has not been explored in Saudi Arabia. So, the purpose of this study was to investigate the association of human leukocyte antigen (HLA)-DRB1 alleles to VKH patients and to clarify the molecular genetic mechanism underlying the susceptibility or resistance to VKH disease. METHODS: Genomic DNA from a total of 30 patients with VKH and 29 control subjects was extracted from peripheral blood, and HLA-DRB1 alleles were typed by polymerase chain reaction and sequence based typing (SBT)...
2009: Molecular Vision
https://www.readbyqxmd.com/read/19091022/evaluation-of-mhc-ii-peptide-binding-prediction-servers-applications-for-vaccine-research
#11
Hong Huang Lin, Guang Lan Zhang, Songsak Tongchusak, Ellis L Reinherz, Vladimir Brusic
BACKGROUND: Initiation and regulation of immune responses in humans involves recognition of peptides presented by human leukocyte antigen class II (HLA-II) molecules. These peptides (HLA-II T-cell epitopes) are increasingly important as research targets for the development of vaccines and immunotherapies. HLA-II peptide binding studies involve multiple overlapping peptides spanning individual antigens, as well as complete viral proteomes. Antigen variation in pathogens and tumor antigens, and extensive polymorphism of HLA molecules increase the number of targets for screening studies...
2008: BMC Bioinformatics
https://www.readbyqxmd.com/read/18930095/structural-and-immunological-analysis-of-circumsporozoite-protein-peptides-a-further-step-in-the-identification-of-potential-components-of-a-minimal-subunit-based-chemically-synthesised-antimalarial-vaccine
#12
Adriana Bermúdez, Magnolia Vanegas, Manuel Elkin Patarroyo
The Plasmodium falciparum circumsporozoite protein is considered a major antimalarial-vaccine target due to its involvement in sporozoite invasion of mosquito's salivary glands and human hepatocytes. The 4383, 4388 and 4389 CSP-conserved high activity hepatocyte binding peptides and their modified analogues were synthesised and their immunogenicity was tested in Aotus monkeys. Peptide 4388 modified analogues induced higher and more permanent antibody titers against sporozoites in approximately 40% of immunised monkeys; whilst peptides 4383 and 4389 modified analogues elicited high, long-lasting antibody titers as well as short-lived antibodies...
December 9, 2008: Vaccine
https://www.readbyqxmd.com/read/18502098/advances-in-the-pathogenesis-of-goodpasture-s-disease-from-epitopes-to-autoantibodies-to-effector-t-cells
#13
REVIEW
Joshua D Ooi, Stephen R Holdsworth, A Richard Kitching
Goodpasture's disease, an "organ-specific" autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of autoantibodies and cellular effectors in disease. The discovery of alpha3(IV)NC1 lead to studies that defined the structure and biology of type IV collagen and are defining B and T cell epitopes...
November 2008: Journal of Autoimmunity
https://www.readbyqxmd.com/read/18451182/comprehensive-analysis-of-hla-a-hla-b-hla-c-hla-drb1-and-hla-dqb1-loci-and-squamous-cell-cervical-cancer-risk
#14
Margaret M Madeleine, Lisa G Johnson, Anajane G Smith, John A Hansen, Brenda B Nisperos, Sue Li, Lue-Ping Zhao, Janet R Daling, Stephen M Schwartz, Denise A Galloway
Variation in human major histocompatibility genes may influence the risk of squamous cell cervical cancer (SCC) by altering the efficiency of the T-cell-mediated immune response to human papillomavirus (HPV) antigens. We used high-resolution methods to genotype human leukocyte antigen (HLA) class I (A, B, and Cw) and class II (DRB1 and DQB1) loci in 544 women with SCC and 542 controls. Recognizing that HLA molecules are codominantly expressed, we focused on co-occurring alleles. Among 137 allele combinations present at >5% in the case or control groups, 36 were significantly associated with SCC risk...
May 1, 2008: Cancer Research
https://www.readbyqxmd.com/read/18450004/toward-the-prediction-of-class-i-and-ii-mouse-major-histocompatibility-complex-peptide-binding-affinity-in-silico-bioinformatic-step-by-step-guide-using-quantitative-structure-activity-relationships
#15
Channa K Hattotuwagama, Irini A Doytchinova, Darren R Flower
Quantitative structure-activity relationship (QSAR) analysis is a cornerstone of modern informatics. Predictive computational models of peptide-major histocompatibility complex (MHC)-binding affinity based on QSAR technology have now become important components of modern computational immunovaccinology. Historically, such approaches have been built around semiqualitative, classification methods, but these are now giving way to quantitative regression methods. We review three methods--a 2D-QSAR additive-partial least squares (PLS) and a 3D-QSAR comparative molecular similarity index analysis (CoMSIA) method--which can identify the sequence dependence of peptide-binding specificity for various class I MHC alleles from the reported binding affinities (IC50) of peptide sets...
2007: Methods in Molecular Biology
https://www.readbyqxmd.com/read/18252895/hla-dr-dq-haplotypes-and-genotypes-and-type-1-diabetes-risk-analysis-of-the-type-1-diabetes-genetics-consortium-families
#16
MULTICENTER STUDY
Henry Erlich, Ana Maria Valdes, Janelle Noble, Joyce A Carlson, Mike Varney, Pat Concannon, Josyf C Mychaleckyj, John A Todd, Persia Bonella, Anna Lisa Fear, Eva Lavant, Anthony Louey, Priscilla Moonsamy
OBJECTIVE: The Type 1 Diabetes Genetics Consortium has collected type 1 diabetic families worldwide for genetic analysis. The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes. RESEARCH DESIGN AND METHODS: Six hundred and seven Caucasian families and 38 Asian families were typed at high resolution for the DRB1, DQA1, and DQB1 loci...
April 2008: Diabetes
https://www.readbyqxmd.com/read/18162709/meta-analysis-of-the-association-between-hla-drb1-allele-and-rheumatoid-arthritis-susceptibility-in-asian-populations
#17
Kyung Ran Jun, Sung Eun Choi, Choong Hwan Cha, Heung Bum Oh, Yong Seok Heo, Hong Yup Ahn, Kwan Jeh Lee
The aims of this study were to summarize results on the association of HLA-DRB1 with rheumatoid arthritis (RA) in Asians and to determine if the shared epitope (SE) hypothesis could explain the meta-analysis results. Among the papers published between January 1987 and July 2006 on RA susceptibility in Asian-Mongoloid populations (Korean, Japanese, Chinese, and Thai), 12 were selected for the metaanalysis. Mongoloid-Asian patients with RA had significantly higher frequencies of HLA-DRB1*0101, *0401, *0410, and *1001 than controls (OR 1...
December 2007: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/17234427/human-leukocyte-antigen-and-interleukin-2-10-and-12p40-cytokine-responses-to-measles-is-there-evidence-of-the-hla-effect
#18
Inna G Ovsyannikova, Jenna E Ryan, Robert M Jacobson, Robert A Vierkant, V Shane Pankratz, Gregory A Poland
HLA class I and class II associations were examined in relation to measles virus-specific cytokine responses in 339 healthy children who had received two doses of live attenuated measles vaccine. Multivariate linear regression modeling analysis revealed suggestions of associations between the expression of DPA1*0201 (p=0.03) and DPA1*0202 (p=0.09) alleles and interleukin-2 (IL-2) cytokine production (global p-value 0.06). Importantly, cytokine production and DQB1 allele associations (global p-value 0.04) revealed that the alleles with the strongest association with IL-10 secretion were DQB1*0302 (p=0...
November 2006: Cytokine
https://www.readbyqxmd.com/read/16829309/hla-alleles-and-haplotypes-in-french-north-african-immigrants
#19
COMPARATIVE STUDY
Béatrice Pédron, Karima Yakouben, Valérie Guérin, Enwar Borsali, Anne Auvrignon, Judith Landman, Corinne Alberti, Guy Leverger, André Baruchel, Ghislaine Sterkers
Human leukocyte antigen (HLA) haplotypes (n = 187) were genotyped and assigned by the mode of inheritance in migrant families from North Africa who reside in the Paris, France, area. The distribution of alleles and haplotypes in that population was compared with the one obtained in a control population of ancient French natives residing in the same area (248 independent haplotypes also assigned by the mode of inheritance were studied). The results in migrants reveal the following: (1) a higher diversity in the distribution of HLA-A and -DRB1 alleles; (2) lower frequencies of alleles common in our region, such as A*0201 B*1501, B*4001, and DRB1*0401 and increased frequencies of minor subtypes, such as A*3002 and DRB1*0402; and (3) distinct distributions of B/Cw, DRB1/DQB1 or B/Cw/DRB1/DQB1 haplotypes...
July 2006: Human Immunology
https://www.readbyqxmd.com/read/16595602/thyrotropin-receptor-epitopes-and-their-relation-to-histocompatibility-leukocyte-antigen-dr-molecules-in-graves-disease
#20
Hidefumi Inaba, William Martin, Anne S De Groot, Shuwen Qin, Leslie J De Groot
CONTEXT: Graves' disease (GD) is characterized by autoimmunity to the TSH receptor (TSHR). OBJECTIVE: We sought to identify T cell epitopes in TSHR that initiate this immune response and their interaction with human histocompatibility leukocyte antigen (HLA) molecules predisposing to GD. DESIGN: We examined the affinity of 31 overlapping peptides spanning the TSHR extracellular domain for binding in vitro to five purified HLA-DR molecules; DRB1*0101 (DR1), DRB1*1501 (DR2), DRB1*0301 (DR3), DRB1*1101 (DR5), and DRB1*0701 (DR7)...
June 2006: Journal of Clinical Endocrinology and Metabolism
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