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https://www.readbyqxmd.com/read/29782986/antiglycation-study-of-hmg-r-inhibitors-and-tocotrienol-against-glycated-bsa-and-ldl-a-comparative-study
#1
Rabia Nabi, Sahir Sultan Alvi, Rizwan Khan, Shafeeque Ahmad, Saheem Ahmad, M Salman Khan
Non-enzymatic glycation mediated advanced glycation end products (AGEs) generation results in the pathogenesis of diabetic complications and atherosclerotic cardiovascular disease (ASCVD) which is greatly influenced by 3-hydroxy-3-methyl-glutaryl Co-A reductase (HMG-R) activity. HMG-R inhibitors, statins, are well known for reducing mortality and morbidity of ASCVD in patients with diabetes due to their pleiotropic effects independent of cholesterol lowering. Due to distinct chemical structures, various statins may play important role in the inhibition of AGEs mediated pathologies...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29777232/maternal-overnutrition-programs-epigenetic-changes-in-the-regulatory-regions-of-hypothalamic-pomc-in-the-offspring-of-rats
#2
Thanuja Gali Ramamoorthy, Tiffany-Jayne Allen, Alison Davies, Erika Harno, Charlotte Sefton, Christopher Murgatroyd, Anne White
BACKGROUND AND OBJECTIVE: Maternal overnutrition has been implicated in affecting the offspring by programming metabolic disorders such as obesity and diabetes, by mechanisms that are not clearly understood. This study aimed to determine the long-term impact of maternal high-fat (HF) diet feeding on epigenetic changes in the offspring's hypothalamic Pomc gene, coding a key factor in the control of energy balance. Further, it aimed to study the additional effects of postnatal overnutrition on epigenetic programming by maternal nutrition...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29769440/elevated-hepatic-expression-of-h19-long-noncoding-rna-contributes-to-diabetic-hyperglycemia
#3
Na Zhang, Tingting Geng, Zhangsheng Wang, Ruling Zhang, Tiefeng Cao, Joao Paulo Camporez, Shi-Ying Cai, Ya Liu, Luisa Dandolo, Gerald I Shulman, Gordon G Carmichael, Hugh S Taylor, Yingqun Huang
Excessive hepatic glucose production (HGP) contributes significantly to the hyperglycemia of type 2 diabetes; however, the molecular mechanism underlying this dysregulation remains poorly understood. Here, we show that fasting temporally increases the expression of H19 long noncoding RNA (lncRNA) in nondiabetic mouse liver, whereas its level is chronically elevated in diet-induced diabetic mice, consistent with the previously reported chronic hepatic H19 increase in diabetic patients. Importantly, liver-specific H19 overexpression promotes HGP, hyperglycemia, and insulin resistance, while H19 depletion enhances insulin-dependent suppression of HGP...
May 17, 2018: JCI Insight
https://www.readbyqxmd.com/read/29755552/efficacy-of-alpha-glucosidase-inhibitor-from-marine-actinobacterium-in-the-control-of-postprandial-hyperglycaemia-in-streptozotocin-stz-induced-diabetic-male-albino-wister-rats
#4
S R Sathish Kumar, K V Bhaskara Rao
The current study was carried out to evaluate the in-vitro and in-vivo efficiency of alpha glucosidase inhibitor of marine actinobacteria in the control of postprandial hyperglycaemia. Soil samples were collected from salterns, coastal area in Kothapatnam, Ongole, Andhra Pradesh, India. Among the actinobacterial isolates tested for yeastα-glucosidase inhibitory activity, only three isolates showed prominent inhibition. The patient isolate was selected and identified as Streptomyces coelicoflavus SRBVIT13 using 16S r-RNA gene sequencing...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29754148/age-prediction-of-children-and-adolescents-aged-6-17-years-an-epigenome-wide-analysis-of-dna-methylation
#5
Chunxiao Li, Wenjing Gao, Ying Gao, Canqing Yu, Jun Lv, Ruoran Lv, Jiali Duan, Ying Sun, Xianghui Guo, Weihua Cao, Liming Li
The DNA methylation age, a good reflection of human aging process, has been used to predict chronological age of adults and newborns. However, the prediction model for children and adolescents was absent. In this study, we aimed to generate a prediction model of chronological age for children and adolescents aged 6-17 years by using age-specific DNA methylation patterns from 180 Chinese twin individuals. We identified 6,350 age-related CpGs from the epigenome-wide association analysis (N=179). 116 known age-related sites in children were confirmed...
May 12, 2018: Aging
https://www.readbyqxmd.com/read/29751837/antioxidant-and-antiapoptotic-effect-of-aqueous-extract-of-pueraria-tuberosa-roxb-ex-willd-dc-on-streptozotocin-induced-diabetic-nephropathy-in-rats
#6
Rashmi Shukla, Somanshu Banerjee, Yamini B Tripathi
BACKGROUND: Oxidative stress and renal apoptosis play a significant role in the progression of diabetic nephropathy. The tubers of Pueraria tuberosa (Roxb. ex Willd.) DC. has been traditionally used as anti-ageing and health promotive tonic. The purpose of this study was to investigate its nephroprotective effect and mechanism via antioxidant and antiapoptotic potential in Streptozotocin-induced diabetic nephropathy (DN) in rats. METHODS: The chemical composition of aqueous extract of Pueraria tuberosa (PTY-2r) was analyzed by gas chromatography-mass spectrometry (GC-MS)...
May 11, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29749435/spag6-silencing-induces-apoptosis-in-the-myelodysplastic-syndrome-cell-line-skm%C3%A2-1-via-the-pten-pi3k-akt-signaling-pathway-in-vitro-and-in-vivo
#7
Jiaxiu Yin, Xinxin Li, Zaili Zhang, Xiaohua Luo, Li Wang, Lin Liu
Apoptosis is a multi-step mechanism of cell self‑destruction for maintaining cellular homeostatic balance. Accumulating evidence indicates that abnormal apoptosis promotes the evolution and progression of myelodysplastic syndromes (MDS). As a novel cancer-testis antigen, sperm‑associated antigen 6 (SPAG6) has been reported to regulate apoptosis through the tumor necrosis factor-related apoptosis-inducing ligand signaling pathway in the MDS cell line SKM‑1. However, the mechanism of the intrinsic cell death pathway for apoptosis induction by SPAG6 silencing is unclear...
May 2, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29745447/dna-methylation-pattern-of-bovine-blastocysts-associated-to-hyperinsulinemia-in-vitro
#8
Denise Laskowski, Patrice Humblot, Marc-André Sirard, Ylva Sjunnesson, Naveed Jhamat, Renée Båge, Göran Andersson
Insulin functions as a regulator of metabolism and plays an important role in reproduction. Hyperinsulinemia is often observed in obesity and diabetes type 2 and is known to impair fertility, but the underlying molecular mechanisms are only partly understood. Metabolic programming through epigenetic mechanisms such as DNA methylation during embryonic development can lead to health implications for the offspring later in life. Our aim was to study the potential effect of hyperinsulinemia on gene expression and DNA methylation of embryos by adding insulin (0...
May 10, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29743320/prospective-longitudinal-study-of-the-pregnancy-dna-methylome-the-us-pregnancy-race-environment-genes-preg-study
#9
Dana M Lapato, Sara Moyer, Emily Olivares, Ananda B Amstadter, Patricia A Kinser, Shawn J Latendresse, Colleen Jackson-Cook, Roxann Roberson-Nay, Jerome F Strauss, Timothy P York
PURPOSE: The goal of the Pregnancy, Race, Environment, Genes study was to understand how social and environmental determinants of health (SEDH), pregnancy-specific environments (PSE) and biological processes influence the timing of birth and account for the racial disparity in preterm birth. The study followed a racially diverse longitudinal cohort throughout pregnancy and included repeated measures of PSE and DNA methylation (DNAm) over the course of gestation and up to 1 year into the postpartum period...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29740313/epigenome-wide-association-study-of-soluble-tumor-necrosis-factor-receptor-2-levels-in-the-framingham-heart-study
#10
Michael M Mendelson, Roby Johannes, Chunyu Liu, Tianxiao Huan, Chen Yao, Xiao Miao, Joanne M Murabito, Josée Dupuis, Daniel Levy, Emelia J Benjamin, Honghuang Lin
Background: Transmembrane tumor necrosis factor (TNF) receptors are involved in inflammatory, apoptotic, and proliferative processes. In the bloodstream, soluble TNF receptor II (sTNFR2) can modify the inflammatory response of immune cells and is predictive of cardiovascular disease risk. We hypothesize that sTNFR2 is associated with epigenetic modifications of circulating leukocytes, which may relate to the pathophysiology underlying atherogenic risk. Methods: We conducted an epigenome-wide association study of sTNFR2 levels in the Framingham Heart Study Offspring cohort (examination 8; 2005-2008)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29737531/specific-expression-network-analysis-of-diabetic-nephropathy-kidney-tissue-revealed-key-methylated-sites
#11
Yan-Zhe Wang, Wen-Wei Xu, Ding-Yu Zhu, Nan Zhang, Yong-Lan Wang, Miao Ding, Xin-Miao Xie, Lin-Lin Sun, Xiao-Xia Wang
Diabetic nephropathy (DN) is one of the most common and serious complication in diabetes patients. However, the evidences of gene regulation mechanism and epigenetic modification with DN remain unclear. Therefore, it is necessary to search regulating genes for early diagnosis on DN. We identified tissue specific genes through mining the gene expression omnibus (GEO) public database, enriched function by gene ontology (GO), and kyoto encyclopedia of genes and genomes (KEGG) analysis, and further compared tissue-specific network...
May 8, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29733914/photodynamic-therapy-of-necrobiosis-lipoidica-using-methyl-aminolevulinate-a-retrospective-follow-up-study
#12
Jeanette Kaae, Peter Alshede Philipsen, Hans Christian Wulf
INTRODUCTION: Necrobiosis lipoidica (NL) is a rare, treatment-resistant, granulomatous skin disease of unknown origin, frequently seen in patients with diabetes. METHODS: In this retrospective study we evaluated the long-term efficacy of methyl aminolaevulinate-based photodynamic therapy (MAL-PDT), including 80 treatments (70 conventional and 10 daylight PDT), on 65 unselected NL patients treated routinely in our clinic. Superficial curettage, avoiding skin oozing or bleeding, was performed prior to MAL application...
May 4, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29732466/novel-insights-into-the-regulation-of-mirna-transcriptional-control-implications-for-t2d-and-related-complications
#13
Lucia La Sala, Stefano Micheloni, Valeria De Nigris, Francesco Prattichizzo, Antonio Ceriello
In recent years, epigenetics has emerged as an important form of biological regulation involving chromatin control of gene expression. The mechanisms of this fine-tuned regulation are susceptible to changes forced by environmental stimuli and nutritional factors and may be potentially reversible. Dysregulation of epigenetic processes has important consequences for the pathogenesis of complex and multifactorial diseases such as type 2 diabetes (T2D) and vascular complications. Along with DNA methylation (DNA-me), histone modifications and RNA-based mechanisms as the major epigenetic controllers, small non-coding RNAs known as microRNAs (miRNAs) have their own important implications for the pathogenesis of diabetes...
May 7, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29730292/altered-expression-of-pgc-1%C3%AE-and-pdx1-and-their-methylation-status-are-associated-with-fetal-glucose-metabolism-in-gestational-diabetes-mellitus
#14
Lizhen Wang, Hailing Fan, Ludan Zhou, Yanjun Wu, Hongping Lu, Jing Luo
PURPOSE: To investigate the effect of gestational diabetes mellitus (GDM) on the expression and methylation of PGC-1α and PDX1 in placenta and their effects on fetal glucose metabolism. METHODS: 20 cases of full-term placenta without pregnancy complications and umbilical cord abnormalities and 20 cases of GDM group were collected. DNA and RNA were isolated from samples of tissue collected from the fetal side of the placenta immediately after delivery. DNA methylation was quantified at 7 CpG sites within the PGC-1α and PDX1 genes using PCR amplification of bisulfite treated DNA and subsequent DNA sequencing...
May 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29729383/ameliorative-potential-of-lavandula-stoechas-in-metabolic-syndrome-via-multitarget-interactions
#15
S S Kulabas, H Ipek, A R Tufekci, S Arslan, I Demirtas, R Ekren, U Sezerman, T B Tumer
ETHNOPHARMACOLOGICAL IMPORTANCE: Decoction and infusion prepared from aerial parts of Lavandula stoechas L. (L. stoechas) have been traditionally used as remedy against several components of metabolic syndrome (MetS) and associated disorders including type II diabetes and cardiovascular diseases by Anatolian people. AIM OF THE STUDY: The aim is to elucidate the potential ameliorative effects of L. stoechas aqueous extracts on insulin resistance and inflammation models through multitarget in vitro approaches and also to elucidate mechanism of action by analyzing transcriptional and metabolic responses...
May 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29724875/unusual-case-of-anti-n-methyl-d-aspartic-acid-receptor-nmda-r-encephalitis-and-autoimmune-polyglandular-syndrome-aps
#16
Simona Frunza-Stefan, Hilary B Whitlatch, Gautam G Rao, Rana Malek
Anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis is a novel disease discovered within the past 10 years. It is an autoimmune disease (AD) that has been associated with other ADs, such as Graves' disease. However, association with autoimmune polyglandular syndromes (APS) has not been previously described. A 58-year-old woman presented with altered mental status and an 8-month history of weight loss, apathy and somnolence. Laboratory evaluation confirmed Graves' disease with thyrotoxicosis and type 1 diabetes mellitus...
May 2, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29721587/prenatal-arsenic-exposure-and-dietary-folate-and-methylcobalamin-supplementation-alter-the-metabolic-phenotype-of-c57bl-6j-mice-in-a-sex-specific-manner
#17
Madelyn C Huang, Christelle Douillet, Ellen N Dover, Miroslav Stýblo
Inorganic arsenic (iAs) is an established environmental diabetogen. The link between iAs exposure and diabetes is supported by evidence from adult human cohorts and adult laboratory animals. The contribution of prenatal iAs exposure to the development of diabetes and underlying mechanisms are understudied. The role of factors that modulate iAs metabolism and toxicity in adults and their potential to influence diabetogenic effects of prenatal iAs exposure are also unclear. The goal of this study was to determine if prenatal exposure to iAs impairs glucose metabolism in mice and if maternal supplementation with folate and methylcobalamin (B12) can modify this outcome...
May 2, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29719458/molecular-signaling-of-ginsenosides-rb1-rg1-and-rg3-and-their-mode-of-actions
#18
REVIEW
Padmanaban Mohanan, Sathiyamoorthy Subramaniyam, Ramya Mathiyalagan, Deok-Chun Yang
Ginseng has gained its popularity as an adaptogen since ancient days because of its triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and classified as protopanaxatriol and protopanaxadiol saponins based on their glycosylation patterns. They play many protective roles in humans and are under intense research as various groups continue to study their efficacy at the molecular level in various disorders. Ginsenosides Rb1 and Rg1 are the most abundant ginsenosides present in ginseng roots, and they confer the pharmacological properties of the plant, whereas ginsenoside Rg3 is abundantly present in Korean Red Ginseng preparation, which is highly known for its anticancer effects...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29709239/cytosine-methylation-predicts-renal-function-decline-in-american-indians
#19
Chengxiang Qiu, Robert L Hanson, Gudeta Fufaa, Sayuko Kobes, Caroline Gluck, Jing Huang, Yong Chen, Dominic Raj, Robert G Nelson, William C Knowler, Katalin Susztak
Diabetic nephropathy accounts for most of the excess mortality in individuals with diabetes, but the molecular mechanisms by which nephropathy develops are largely unknown. Here we tested cytosine methylation levels at 397,063 genomic CpG sites for association with decline in the estimated glomerular filtration rate (eGFR) over a six year period in 181 diabetic Pima Indians. Methylation levels at 77 sites showed significant association with eGFR decline after correction for multiple comparisons. A model including methylation level at two probes (cg25799291 and cg22253401) improved prediction of eGFR decline in addition to baseline eGFR and the albumin to creatinine ratio with the percent of variance explained significantly improving from 23...
April 27, 2018: Kidney International
https://www.readbyqxmd.com/read/29705508/biosynthesis-of-iron-nanoparticles-using-trigonella-foenum-graecum-seed-extract-for-photocatalytic-methyl-orange-dye-degradation-and-antibacterial-applications
#20
Ibrahim Ali Radini, Nazim Hasan, Maqsood Ahmad Malik, Zaheer Khan
Trigonella foenum-graecum is the source of various biological and chemical constituents with a wide area of applications, especially in the treatment/prevention of diabetes and other chronic diseases such as cancer. Multiple biological and organic moieties in the aqueous or the organic phase of Trigonella foenum-graecum carry soft reduction properties to reduce the metal cations to nanoparticles. In this investigation, the Trigonella foenum-graecum was found in the seed extract for the first time in an aqueous medium...
April 17, 2018: Journal of Photochemistry and Photobiology. B, Biology
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