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https://www.readbyqxmd.com/read/28644236/cyp1b1-cytopathy-uncommon-phenotype-of-a-homozygous-cyp1b1-deletion-as-internal-corneal-ulcer-of-von-hippel
#1
Valeria Oliva-Biénzobas, Alejandro Navas, Mirena C Astiazarán, Oscar Francisco Chacón-Camacho, Jose A Bermúdez-Magner, Mariana Takane, Enrique Graue-Hernández, Juan Carlos Zenteno
PURPOSE: To report a mutation of CYP1B1 in a newborn with a rare phenotype without the classic features of anterior segment dysgenesis or congenital glaucoma. METHODS: The newborn presented with diffuse corneal edema and bilaterally elevated intraocular pressure (IOP). Ophthalmological examination, ultrasound, and ultrasound biomicroscopy were performed; congenital infections were ruled out. Genetic analysis was performed. The patient underwent penetrating keratoplasty and goniotomy in a single surgical time...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28632946/emerging-biomarkers-of-illness-severity-urinary-metabolites-associated-with-sepsis-and-necrotizing-methicillin-resistant-staphylococcus-aureus-pneumonia
#2
Lilliam Ambroggio, Todd A Florin, Samir S Shah, Richard Ruddy, Larisa Yeomans, Julie Trexel, Kathleen A Stringer
STUDY OBJECTIVE: To illustrate the potential of metabolomics to identify novel biomarkers of illness severity in a child with fatal necrotizing pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA). DESIGN: Case report with two control groups and a metabolomics analysis. PATIENTS: An infant with fatal MRSA pneumonia, four children with influenza pneumonia (pneumonia control group), and seven healthy children with no known infections (healthy control group)...
June 20, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28624364/decision-making-in-swiss-home-like-childbirth-a-grounded-theory-study
#3
Yvonne Meyer, Franziska Frank, Franziska Schläppy Muntwyler, Valerie Fleming, Jessica Pehlke-Milde
BACKGROUND: Decision-making in midwifery, including a claim for shared decision-making between midwives and women, is of major significance for the health of mother and child. Midwives have little information about how to share decision-making responsibilities with women, especially when complications arise during birth. AIM: To increase understanding of decision-making in complex home-like birth settings by exploring midwives' and women's perspectives and to develop a dynamic model integrating participatory processes for making shared decisions...
June 14, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28587872/validation-of-an-automated-tractography-method-for-the-optic-radiations-as-a-biomarker-of-visual-acuity-in-neurofibromatosis-associated-optic-pathway-glioma
#4
REVIEW
Peter de Blank, Michael J Fisher, Haley Gittleman, Jill S Barnholtz-Sloan, Chaitra Badve, Jeffrey I Berman
INTRODUCTION: Fractional anisotropy (FA) of the optic radiations has been associated with vision deficit in multiple intrinsic brain pathologies including NF1 associated optic pathway glioma, but hand-drawn regions of interest used in previous tractography methods limit consistency of this potential biomarker. We created an automated method to identify white matter tracts in the optic radiations and compared this method to previously reported hand-drawn tractography. METHOD: Automated tractography of the optic radiation using probabilistic streamline fiber tracking between the lateral geniculate nucleus of the thalamus and the occipital cortex was compared to the hand-drawn method between regions of interest posterior to Meyer's loop and anterior to tract branching near the calcarine cortex...
June 3, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28578671/serious-child-and-adolescent-behaviour-disorders-a-valuation-study-by-professionals-youth-and-parents
#5
Karin M Vermeulen, Daniëlle E M C Jansen, Erik Buskens, Erik J Knorth, Sijmen A Reijneveld
BACKGROUND: In child and youth care, quantitative estimates of the impact of serious behaviour problems have not yet been made. Such input is needed to support decision making on investments in treatment. The aim of this paper was to elicit valuations of social and conduct disorders in children and adolescents from three different perspectives: professionals, youth, and parents. METHODS: We obtained valuations from 25 youth care professionals, 50 children (age 9-10) without serious behaviour problems and 36 adolescents (age 16-17) with and without serious behaviour disorders, and 46 parents with children in the aforementioned age categories...
June 2, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28448430/family-dog-assisted-adapted-physical-activity-a-case-study
#6
Amanda Tepfer, Samantha Ross, Megan MacDonald, Monique A R Udell, Craig Ruaux, Wendy Baltzer
Purpose: The aim of this case study was to examine the individual effects of an adapted physical activity, animal-assisted intervention (APA-AAI) with the family dog on motor skills, physical activity, and quality of life of a child with cerebral palsy (CP). Method: This study used an A-B-A single-subject design. The assessment phase (phase A) occurred pre- and post-intervention. This consisted of standardized assessments of motor skills, quality of life questionnaires, physical activity (measured using the GT3X+ accelerometer) and the human-animal bond...
April 27, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28444501/validation-of-numerical-simulation-methods-in-aortic-arch-using-4d-flow-mri
#7
Shohei Miyazaki, Keiichi Itatani, Toyoki Furusawa, Teruyasu Nishino, Masataka Sugiyama, Yasuo Takehara, Satoshi Yasukochi
Computational fluid dynamics (CFD) are the gold standard in studying blood flow dynamics. However, CFD results are dependent on the boundary conditions and the computation model. The purpose of this study was to validate CFD methods using comparison with actual measurements of the blood flow vector obtained with four-dimensional (4D) flow magnetic resonance imaging (MRI). 4D Flow MRI was performed on a healthy adult and a child with double-aortic arch. The aortic lumen was segmented to visualize the blood flow...
April 25, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28432112/reduction-of-severe-visual-loss-and-complications-following-intra-arterial-chemotherapy-iac-for-refractory-retinoblastoma
#8
M Ashwin Reddy, Zishan Naeem, Catriona Duncan, Fergus Robertson, Jane Herod, Adam Rennie, Alki Liasis, Dorothy Ann Thompson, Mandeep Sagoo
BACKGROUND: Intra-arterial chemotherapy (IAC) for retinoblastoma has been documented as causing visual loss and ocular motility problems. A lack of safety data has precluded its acceptance in all centres. METHODS: Retrospective cohort study of patients with retinoblastoma from 2013 to 2015 who had a healthy foveola and relapsed following systemic chemotherapy. All required IAC. The correlation of complications with doses of melphalan +/- topotecan used and putative catheterisation complications was assessed...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28327110/an-assessment-of-the-impacts-of-child-oral-health-in-indonesia-and-associations-with-self-esteem-school-performance-and-perceived-employability
#9
Diah Ayu Maharani, Melissa Adiatman, Anton Rahardjo, Girvan Burnside, Cynthia Pine
BACKGROUND: Previous surveys have indicated that a majority of Indonesian children have poor oral health. However, little detailed information is available on underlying causation and none that examine impacts of oral health on child self-esteem, school performance and perceived employability. The aim of this study was to determine levels of child oral health in primary school children in Indonesia, the prevalence of key causal factors; and, to determine relationships between oral health, self-esteem and school academic performance...
March 21, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28104697/male-birthweight-semen-quality-and-birth-outcomes
#10
B W Whitcomb, M S Bloom, S Kim, Z Chen, G M Buck Louis
STUDY QUESTION: What are the relations among birthweight (BW), semen parameters and birth outcomes in a population-based sample? SUMMARY ANSWER: BW is unrelated to semen parameters, which are in turn unrelated to birth outcomes. WHAT IS KNOWN ALREADY: In clinical settings, there has been suggestion that semen parameters are related to BW when comparing fertile and infertile men; however, findings have been less clear in more general populations...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28103872/the-use-of-the-eq-5d-y-health-related-quality-of-life-outcome-measure-in-children-in-the-western-cape-south-africa-psychometric-properties-feasibility-and-usefulness-a-longitudinal-analytical-study
#11
Des Scott, Gillian D Ferguson, Jennifer Jelsma
BACKGROUND: The EQ-5D-Y, an outcome measure of Health Related Quality of Life (HRQoL) in children, was developed by an international task team in 2010. The multinational feasibility, reliability and validity study which followed was undertaken with mainly healthy children. The aim of this study was to investigate the psychometric properties of the EQ-5D-Y when used to assess the HRQoL of children with different health states. METHOD: A sample of 224 children between eight and twelve years were grouped according to their health state...
January 19, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27902832/association-of-irritability-and-anxiety-with-the-neural-mechanisms-of-implicit-face-emotion-processing-in-youths-with-psychopathology
#12
Joel Stoddard, Wan-Ling Tseng, Pilyoung Kim, Gang Chen, Jennifer Yi, Laura Donahue, Melissa A Brotman, Kenneth E Towbin, Daniel S Pine, Ellen Leibenluft
Importance: Psychiatric comorbidity complicates clinical care and confounds efforts to elucidate the pathophysiology of commonly occurring symptoms in youths. To our knowledge, few studies have simultaneously assessed the effect of 2 continuously distributed traits on brain-behavior relationships in children with psychopathology. Objective: To determine shared and unique effects of 2 major dimensions of child psychopathology, irritability and anxiety, on neural responses to facial emotions during functional magnetic resonance imaging...
January 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/27793520/influence-of-cartoon-media-characters-on-children-s-attention-to-and-preference-for-food-and-beverage-products
#13
Andrew D Ogle, Dan J Graham, Rachel G Lucas-Thompson, Christina A Roberto
BACKGROUND: Over-consuming unhealthful foods and beverages contributes to pediatric obesity and associated diseases. Food marketing influences children's food preferences, choices, and intake. OBJECTIVE: To examine whether adding licensed media characters to healthful food/beverage packages increases children's attention to and preference for these products. We hypothesized that children prefer less- (vs more-) healthful foods, and pay greater attention to and preferentially select products with (vs without) media characters regardless of nutritional quality...
February 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27756269/acute-multifocal-hemorrhagic-retinal-vasculitis-in-a-child-a-case-report
#14
Malik Y Ghannam, Mohammed Naseemuddin, Peter Weiser, John O Mason
BACKGROUND: Acute Multifocal Hemorrhagic Retinal Vasculitis (AMHRV) is a rare disease with unknown incidence that presents with abrupt onset of visual loss associated with retinal vasculitis, retinal hemorrhage, non-confluent posterior retinal infiltrates, vitreous cellular inflammation and papillitis in, otherwise, healthy adult individuals. The reported treatment options for Acute Multifocal Hemorrhagic Retinal Vasculitis are oral corticosteroids, intravitreal ganciclovir and laser photocoagulation or vitrectomy...
October 18, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27716964/immediate-neural-plasticity-involving-reaction-time-in-a-saccadic-eye-movement-task-is-intact-in-children-with-fetal-alcohol-spectrum-disorder
#15
Angelina Paolozza, Douglas P Munoz, Donald Brien, James N Reynolds
BACKGROUND: Saccades are rapid eye movements that bring an image of interest onto the retina. Previous research has found that in healthy individuals performing eye movement tasks, the location of a previous visual target can influence performance of the saccade on the next trial. This rapid behavioral adaptation represents a form of immediate neural plasticity within the saccadic circuitry. Our studies have shown that children with fetal alcohol spectrum disorder (FASD) are impaired on multiple saccade measures...
November 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27617181/feasibility-accuracy-and-repeatability-of-suprathreshold-saccadic-vector-optokinetic-perimetry
#16
Ian C Murray, Lorraine A Cameron, Alice D McTrusty, Antonios Perperidis, Harry M Brash, Brian W Fleck, Robert A Minns
PURPOSE: To evaluate feasibility, accuracy, and repeatability of suprathreshold Saccadic Vector Optokinetic Perimetry (SVOP) by comparison with Humphrey Field Analyzer (HFA) perimetry. METHODS: The subjects included children with suspected field defects (n = 10, age 5-15 years), adults with field defects (n = 33, age 39-78 years), healthy children (n = 12, age 6-14 years), and healthy adults (n = 30, age 16-61 years). The test protocol comprised repeat suprathreshold SVOP and HFA testing with the C-40 test pattern...
August 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27514723/school-meal-provision-health-and-cognitive-function-in-a-nordic-setting-the-promeal-study-description-of-methodology-and-the-nordic-context
#17
Maria Waling, Anna S Olafsdottir, Hanna Lagström, Hege Wergedahl, Bert Jonsson, Cecilia Olsson, Eldbjørg Fossgard, Asle Holthe, Sanna Talvia, Ingibjorg Gunnarsdottir, Agneta Hörnell
BACKGROUND: School meals, if both nutritious and attractive, provide a unique opportunity to improve health equality and public health. OBJECTIVE: To describe the study rationale, data collection, and background of participants in the study 'Prospects for promoting health and performance by school meals in Nordic countries' (ProMeal). The general aim was to determine whether overall healthiness of the diet and learning conditions in children can be improved by school lunches, and to capture the main concerns regarding school lunches among children in a Nordic context...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27479051/relationship-between-parental-feeding-practices-and-neural-responses-to-food-cues-in-adolescents
#18
Harriet A Allen, Alison Chambers, Jacqueline Blissett, Magdalena Chechlacz, Timothy Barrett, Suzanne Higgs, Arie Nouwen
Social context, specifically within the family, influences adolescent eating behaviours and thus their health. Little is known about the specific mechanisms underlying the effects of parental feeding practices on eating. We explored relationships between parental feeding practices and adolescent eating habits and brain activity in response to viewing food images. Fifty- seven adolescents (15 with type 2 diabetes mellitus, 21 obese and 21 healthy weight controls) underwent fMRI scanning whilst viewing images of food or matched control images...
2016: PloS One
https://www.readbyqxmd.com/read/27373939/a-case-of-optic-neuritis-concomitant-with-pituitary-tumor-during-pregnancy
#19
Rei Yamaguchi, Hideaki Kohga, Masahiko Tosaka, Akiko Sekine, Kazuyuki Mizushima, Yasuo Harigaya, Yuhei Yoshimoto
BACKGROUND: Optic neuritis (ON) is unilateral painful optic nerve inflammation in a young healthy female diagnosed by excluding glaucoma. ON onset during pregnancy is rare, with only 2 cases reported to date. CASE DESCRIPTION: A 35-year-old previously healthy parous woman who was pregnant with her second child suffered rapidly progressive visual acuity loss. Magnetic resonance imaging (MRI) revealed a pituitary tumor. Emergency surgery was performed for optic nerve compression; however, her visual impairment worsened...
September 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27349039/-cerebral-blood-flow-during-neurocardiogenic-syncopes-in-children
#20
Aleksandra Gergont, Katarzyna Kurdziel, Urszula Stolarska-Weryńska
BACKGROUND: Neurocardiogenic syncope, the most common episodic event in children results from global cerebral hypoperfusion. Monitoring of the blood flow during head-up tilt-induced syncope resulted in registration of preferential reduction of end-diastolic velocities in middle cerebral arteries (MCA). The significance of those changes was however not explained. The aim of this retrospective research was to establish the significance of visual inspection of spectra changes of cerebral blood flow in MCA during presyncope and syncope in children...
2016: Przegla̧d Lekarski
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