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https://www.readbyqxmd.com/read/28723654/disrupted-small-world-brain-network-topology-in-pure-conduct-disorder
#1
Feng-Mei Lu, Jian-Song Zhou, Jiang Zhang, Xiao-Ping Wang, Zhen Yuan
OBJECTIVES: Conduct disorder (CD) is characterized by the violation of the rights of others or basic social rules and a repetitive, persistent pattern of antisocial and aggressive behaviors. A large number of functional and structural neuroimaging studies have identified widely abnormalities in specific brain regions in CD, but the alterations in the topological organization of functional networks among them remain largely unknown. METHODS: Resting-state functional magnetic resonance imaging was applied to investigate the intrinsic functional connectivity in 18 pure CD patients and eighteen typically developing healthy controls...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722821/sensory-strategies-of-postural-sway-during-quiet-stance-in-patients-with-haemophilic-arthropathy
#2
C Cruz-Montecinos, C De la Fuente, G Rivera-Lillo, S Morales-Castillo, V Soto-Arellano, F Querol, S Pérez-Alenda
INTRODUCTION: The sensory strategies of postural control in adult haemophilic arthropathy patients are still poorly understood. AIM: To determine sensorial posture-control strategies through postural sway frequency analysis when in a bipedal quiet stance with and without visual stimulus deprivation in healthy subjects and patients with haemophilic arthropathy. Secondarily, to determine the irregularity of postural balance control through sample entropy (SampEn)...
July 19, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28722347/foxo3-longevity-interactome-on-chromosome-6
#3
Timothy A Donlon, Brian J Morris, Randi Chen, Kamal H Masaki, Richard C Allsopp, D Craig Willcox, Ayako Elliott, Bradley J Willcox
FOXO3 has been implicated in longevity in multiple populations. By DNA sequencing in long-lived individuals, we identified all single nucleotide polymorphisms (SNPs) in FOXO3 and showed 41 were associated with longevity. Thirteen of these had predicted alterations in transcription factor binding sites. Those SNPs appeared to be in physical contact, via RNA polymerase II binding chromatin looping, with sites in the FOXO3 promoter, and likely function together as a cis-regulatory unit. The SNPs exhibited a high degree of LD in the Asian population, in which they define a specific longevity haplotype that is relatively common...
July 19, 2017: Aging Cell
https://www.readbyqxmd.com/read/28722267/simultaneous-bright-and-black-blood-whole-heart-mri-for-noncontrast-enhanced-coronary-lumen-and-thrombus-visualization
#4
Giulia Ginami, Radhouene Neji, Alkystis Phinikaridou, John Whitaker, René M Botnar, Claudia Prieto
PURPOSE: To develop a 3D whole-heart Bright-blood and black-blOOd phase SensiTive (BOOST) inversion recovery sequence for simultaneous noncontrast enhanced coronary lumen and thrombus/hemorrhage visualization. METHODS: The proposed sequence alternates the acquisition of two bright-blood datasets preceded by different preparatory pulses to obtain variations in blood/myocardium contrast, which then are combined in a phase-sensitive inversion recovery (PSIR)-like reconstruction to obtain a third, coregistered, black-blood dataset...
July 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28721992/comparative-evaluation-of-effectiveness-of-intra-pocket-anesthetic-gel-and-injected-local-anesthesia-during-scaling-and-root-planing-a-split-mouth-clinical-trial
#5
Kalyan Chintala, Sandhya Pavan Kumar, K Raja V Murthy
BACKGROUND AND AIM: Pain control is an important outcome measure for successful periodontal therapy. Injected local anesthesia has been used to secure anesthesia for scaling and root planing (SRP) and continues to be the anesthetic of choice for pain control. Alternatively, intra-pocket anesthetic gel has been used as an anesthetic during SRP. Hence, this clinical trial was done to compare the effectiveness of intra-pocket anesthetic gel and injected local anesthesia during SRP and also to assess the influence of intra-pocket anesthetic gel on treatment outcomes in chronic periodontitis patients...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28721740/clinical-features-and-subjective-physiological-responses-to-emotional-stimuli-in-the-presence-of-emotion-dysregulation-in-attention-deficit-hyperactivity-disorder
#6
Candan Taskiran, Serkan Karaismailoglu, Halime Tuna Cak Esen, Zeynep Tuzun, Aysen Erdem, Zeynep Dicle Balkanci, Anil Barak Dolgun, Sadriye Ebru Cengel Kultur
INTRODUCTION: Emotion dysregulation (ED) has long been recognized in clinical descriptions of attention-deficit hyperactivity disorder (ADHD), but a renewed interest in ED has advanced research on the overlap between the two entities. Autonomic reactivity (AR) is a neurobiological correlate of emotion regulation; however, the association between ADHD and AR remains unclear. Our aim was to explore the clinical differences, AR, and subjective emotional responses to visual emotional stimuli in ADHD children with and without ED...
July 19, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28719854/clinically-silent-alzheimer-s-and-vascular-pathologies-influence-brain-networks-supporting-executive-function-in-healthy-older-adults
#7
Brian T Gold, Christopher A Brown, Jonathan G Hakun, Leslie M Shaw, John Q Trojanowski, Charles D Smith
Aging is associated with declines in executive function. We examined how executive functional brain systems are influenced by clinically silent Alzheimer's disease (AD) pathology and cerebral white-matter hyperintensities (WMHs). Twenty-nine younger adults and 34 cognitively normal older adults completed a working memory paradigm while functional magnetic resonance imaging was performed. Older adults further underwent lumbar cerebrospinal fluid draw for the assessment of AD pathology and FLAIR imaging for the assessment of WMHs...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28719746/structure-activity-study-of-ghrelin-1-8-resulting-in-high-affinity-fluorine-bearing-ligands-for-the-ghrelin-receptor
#8
Carlie L Charron, Jin-Qiang Hou, Mark S McFarland, Savita Dhanvantari, Michael S Kovacs, Leonard G Luyt
The ghrelin receptor, also known as the growth hormone secretagogue receptor 1a (GHS-R1a), is a G-protein coupled receptor that is differentially expressed in healthy tissue and several cancers, including prostate, testicular, and ovarian. Selectively targeting the ghrelin receptor using fluorine-18 tagged entities would allow localization and visualization of ghrelin receptor expressing carcinomas using PET imaging. The endogenous ligand ghrelin, a 28 amino acid peptide with 3.1 nM affinity, has poor in vivo stability...
July 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28719550/does-an-annular-puncture-influence-the-herniation-path-an-in-vitro-mechanical-and-structural-investigation
#9
Vonne M van Heeswijk, Ashvin Thambyah, Peter A Robertson, Neil D Broom
STUDY DESIGN: A study of mechanically-induced herniation in punctured ovine discs followed by structural analysis. OBJECTIVE: To investigate whether an annular puncture influences the path that herniation takes by providing direct passage for nucleus through the annulus and therefore whether it increases the risk of acute herniation from overload at the site of damage independent of any longer-term degeneration. SUMMARY OF BACKGROUND DATA: 10 years after treatment with discography both degenerative changes and frequency of herniation have been shown to increase compared to untreated discs...
July 17, 2017: Spine
https://www.readbyqxmd.com/read/28716680/three-dimensional-adiabatic-inversion-recovery-prepared-ultrashort-echo-time-cones-3d-ir-ute-cones-imaging-of-cortical-bone-in-the-hip
#10
Amin Nazaran, Michael Carl, Yajun Ma, Saeed Jerban, Yanchun Zhu, Xing Lu, Jiang Du, Eric Y Chang
PURPOSE: We present three-dimensional adiabatic inversion recovery prepared ultrashort echo time Cones (3D IR-UTE-Cones) imaging of cortical bone in the hip of healthy volunteers using a clinical 3T scanner. METHODS: A 3D IR-UTE-Cones sequence, based on a short pulse excitation followed by a 3D Cones trajectory, with a nominal TE of 32μs, was employed for high contrast morphological imaging of cortical bone in the hip of heathy volunteers. Signals from soft tissues such as muscle and marrow fat were suppressed via adiabatic inversion and signal nulling...
July 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28716538/reliability-of-pelvic-floor-muscle-electromyography-tested-on-healthy-women-and-women-with-pelvic-floor-muscle-dysfunction
#11
Irene Koenig, Helena Luginbuehl, Lorenz Radlinger
OBJECTIVES: Electromyography (EMG) is a well-established method to quantify the relative pelvic floor muscle (PFM) activity. PFM EMG has shown good reliability in healthy women. However, its reliability has not been tested in women with PFM dysfunction. The reliability of EMG analysis methods concerning EMG normalization needs to be determined to assess specific therapeutic interventions. Therefore, the aim of this study was to investigate the intra-session reliability of PFM EMG variables by using 3 different analysis methods in women with PFM dysfunction...
July 14, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28716512/results-of-the-dubert-procedure-for-chronic-painful-fracture-dislocations-of-the-fifth-carpometacarpal-joint-a-report-of-6-cases
#12
N Meraghni, G Bacle, E Marteau, Y Bouju, J Laulan
Carpometacarpal (CMC) fracture-dislocations of the fifth ray are common. For chronic injuries, Dubert proposed combining resection arthroplasty of the base of the fifth metacarpal (M5) with synostosis with the fourth metacarpal (M4). Our aim was to evaluate the results of this procedure. Between 1994 and 2014, 7 men and 1 woman with an average age of 36 years (range, 27 to 45) were operated on. The right hand was involved in 6 of the 8 cases. All patients had symptomatic osteoarthritis secondary to isolated articular malunion and subluxation of the 5th CMC joint...
July 14, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28716057/the-peripheral-and-central-humphrey-visual-field-morphological-changes-during-aging
#13
Paul Rutkowski, Christian Albrecht May
BACKGROUND: To define age-related changes in the visual field by comparing 'standard' central and unique peripheral visual field measurements in healthy volunteers. METHODS: In a single center, retrospective, Cross-sectional, observational study, 20 volunteers with no retinal diseases or risk factors, ranging in age between 30 and 94 years (four age groups: 30's, 50's, 70's, 90's) were measured in one eye (preferentially the right one) using a Humphrey visual field 24-2 and 60-4...
July 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28715995/pacinian-signals-determine-the-direction-and-magnitude-of-the-effect-of-vibration-on-pain
#14
Mark Hollins, Christopher Corsi, Page Sloan
Although the ability of vibration to reduce pain has been extensively documented, an occasional participant reports that vibration increases pain. For pain patients, such reports may reflect pathophysiology, but this is unlikely in studies of experimental pain in healthy participants. In the present series of experiments on 27 pain-free individuals, we manipulated both the frequency (12, 50, and 80 Hz) and amplitude of vibration to more fully characterize vibratory pain modulation. The noxious stimulus was pressure applied to a finger, and vibration was delivered to the fleshy palmar pad at the base of the same finger...
August 2017: Perception
https://www.readbyqxmd.com/read/28715353/learned-expectations-and-uncertainty-facilitate-pain-during-classical-conditioning
#15
Veronique A Taylor, Luke Chang, Pierre Rainville, Mathieu Roy
Pain spontaneously activates adaptive and dynamic learning processes affecting the anticipation of, and the responses to, future pain. Computational models of associative learning effectively capture the production and ongoing changes in conditioned anticipatory responses (eg, skin conductance response), but the impact of this dynamic process on unconditional pain responses remains poorly understood. Here, we investigated the dynamic modulation of pain and the nociceptive flexion reflex by fear learning in healthy human adult participants undergoing a classical conditioning procedure involving an acquisition, reversal and extinction phase...
August 2017: Pain
https://www.readbyqxmd.com/read/28715331/the-importance-of-haptics-in-generating-exoskeleton-gait-trajectory-using-alternate-motor-inputs
#16
Kiran K Karunakaran, Kevin M Abbruzzese, Hao Xu, Richard A Foulds
Human gait requires both haptic and visual feedback to generate and control rhythmic movements, and navigate environmental obstacles. Current lower extremity wearable exoskeletons that restore gait to individuals with paraplegia due to spinal cord injury rely completely on visual feedback to generate limited pre-programmed gait-variations, and generally provide little control by the user over the gait cycle. As an alternative to this limitation, we propose user control of gait in real time using healthy upper extremities...
July 13, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28714838/lower-extremity-muscle-activity-kinematics-and-dynamic-postural-control-in-individuals-with-patellofemoral-pain
#17
Shiho Goto, Naoko Aminaka, Phillip A Gribble
CONTEXT: Altered lower extremity muscle activity has been suggested to be associated with lower extremity kinematics in individuals with patellofemoral pain (PFP). However, few studies examined these relationships and the results are inconsistent. OBJECTIVES: To compare the lower extremity muscle activity, kinematics, pain level, and reach distance during the anterior reach of the Star Excursion Balance Test (SEBT) between participants with PFP and healthy individuals (CON)...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28714584/oscillations-during-observations-dynamic-oscillatory-networks-serving-visuospatial-attention
#18
Alex I Wiesman, Elizabeth Heinrichs-Graham, Amy L Proskovec, Timothy J McDermott, Tony W Wilson
The dynamic allocation of neural resources to discrete features within a visual scene enables us to react quickly and accurately to salient environmental circumstances. A network of bilateral cortical regions is known to subserve such visuospatial attention functions; however the oscillatory and functional connectivity dynamics of information coding within this network are not fully understood. Particularly, the coding of information within prototypical attention-network hubs and the subsecond functional connections formed between these hubs have not been adequately characterized...
July 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28714429/structural-brain-correlations-of-visuospatial-and-visuoperceptual-tests-in-parkinson-s-disease
#19
Anna Isabel Garcia-Diaz, Barbara Segura, Hugo Cesar Baggio, Maria Jose Marti, Francesc Valldeoriola, Yaroslau Compta, Nuria Bargallo, Carme Uribe, Anna Campabadal, Alexandra Abos, Carme Junque
BACKGROUND: Diagnosis of mild cognitive impairment in Parkinson's disease (PD) is relevant because it is a marker for evolution to dementia. However, the selection of suitable tests to evaluate separate cognitive domains in mild cognitive impairment related to PD remains an open question. The current work aims to investigate the neuroanatomical correlates of several visuospatial/visuoperceptual tests using the same sample and a multimodal MRI approach. METHODS: The study included 36 PD patients and 20 healthy subjects matched for age, sex, and education...
July 17, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28713977/analysis-of-gene-expression-profile-microarray-data-in-complex-regional-pain-syndrome
#20
Wulin Tan, Yiyan Song, Chengqiang Mo, Shuangjian Jiang, Zhongxing Wang
The aim of the present study was to predict key genes and proteins associated with complex regional pain syndrome (CRPS) using bioinformatics analysis. The gene expression profiling microarray data, GSE47603, which included peripheral blood samples from 4 patients with CRPS and 5 healthy controls, was obtained from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) in CRPS patients compared with healthy controls were identified using the GEO2R online tool. Functional enrichment analysis was then performed using The Database for Annotation Visualization and Integrated Discovery online tool...
July 12, 2017: Molecular Medicine Reports
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