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https://www.readbyqxmd.com/read/29050394/cortical-neurons-and-networks-are-dormant-but-fully-responsive-during-isoelectric-brain-state
#1
Tristan Altwegg-Boussac, Adrien E Schramm, Jimena Ballestero, Fanny Grosselin, Mario Chavez, Sarah Lecas, Michel Baulac, Lionel Naccache, Sophie Demeret, Vincent Navarro, Séverine Mahon, Stéphane Charpier
A continuous isoelectric electroencephalogram reflects an interruption of endogenously-generated activity in cortical networks and systematically results in a complete dissolution of conscious processes. This electro-cerebral inactivity occurs during various brain disorders, including hypothermia, drug intoxication, long-lasting anoxia and brain trauma. It can also be induced in a therapeutic context, following the administration of high doses of barbiturate-derived compounds, to interrupt a hyper-refractory status epilepticus...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050185/-optical-coherence-tomography-angiography-of-acute-vogt-koyanagi-harada-disease
#2
S S Jia, C Zhao, D Gong, Z Chen, M F Zhang
Objective: To measure vascular density in retinal and choroidal capillary layers by optical coherence tomography angiography (OCTA) and to explore their potential clinical values in Vogt-Koyanagi-Harada disease (VKH). Methods: This is a cross-sectional case-control study. Twenty-one acute VKH cases presented to Peking Union Medical College Hospital between April 2015 and July 2015 and 49 healthy controls were enrolled in this study. OCTA was performed with a split-spectrum amplitude-decorrelation angiography-optical coherence tomography (SSADA-OCT) system borrowed from Optovue Inc...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29049405/differences-in-pupillary-light-reflex-between-optic-neuritis-and-ischemic-optic-neuropathy
#3
Yung Ju Yoo, Jeong-Min Hwang, Hee Kyung Yang
OBJECTIVES: To determine the differences in pupillary light reflex (PLR) between the acute and chronic phases of optic neuritis (ON) and nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: The study included 30 patients with ON and 22 patients with NAION whose PLR were measured by a dynamic pupillometer (PLR-200; NeurOptics Inc., Irvine, USA). Age-matched controls included 58 healthy individuals with normal vision and optic nerve function. Pupil diameters, latency, constriction ratio, constriction velocity and dilation velocity were noted...
2017: PloS One
https://www.readbyqxmd.com/read/29048235/role-of-constant-random-and-blocked-practice-in-an-electromyography-based-oral-motor-learning-task
#4
Ramesh Kaipa, Roha Mariam Kaipa
PURPOSE: The role of principles of motor learning (PMLs) in speech has received much attention in the past decade. Oral motor learning, however, has not received similar consideration. This study evaluated the role of three practice conditions in an oral motor tracking task. METHOD: Forty-five healthy adult participants were randomly and equally assigned to one of three practice conditions (constant, blocked, and random) and participated in an electromyography-based task...
October 19, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29046936/localization-of-helotialean-fungi-on-ectomycorrhizae-of-castanopsis-cuspidata-visualized-by-in-situ-hybridization
#5
Noritaka Nakamura, Eiji Tanaka, Chihiro Tanaka, Yuko Takeuchi-Kaneko
Non-ectomycorrhizal fungi that associate with typical ectomycorrhizae often remain hidden, and their localization inside ectomycorrhizal (ECM) roots has remained uncharacterized. In this study, the fungal community associated with the ectomycorrhizae of Castanopsis cuspidata was investigated using a culture-dependent isolation technique. Additionally, the species composition and localization were determined using molecular techniques. The results of the isolation and identification of fungal species revealed the predominance of a few species belonging to the order Helotiales...
October 18, 2017: Mycorrhiza
https://www.readbyqxmd.com/read/29046428/spatio-temporal-characteristics-of-retinal-response-to-network-mediated-photovoltaic-stimulation
#6
Elton Ho, Richard Smith, Georges A Goetz, Xin Lei, Ludwig Galambos, Theodore I Kamins, James Harris, Keith Mathieson, Daniel Palanker, Alexander Sher
Subretinal prostheses aim at restoring sight to patients blinded by photoreceptor degeneration using electrical activation of the surviving inner retinal neurons. Today, such implants deliver visual information with low-frequency stimulation, resulting in discontinuous visual percepts. We measured retinal responses to complex visual stimuli delivered at video rate via a photovoltaic subretinal implant and by visible light. Using a multielectrode array to record from retinal ganglion cells (RGCs) in the healthy and degenerated rat retina ex-vivo, we estimated their spatio-temporal properties from the spike-triggered average (STA) responses to photovoltaic binary white noise stimulus with 70μm pixel size at 20Hz frame rate...
October 18, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29046290/re-establishing-brain-networks-in-patients-with-esrd-after-successful-kidney-transplantation
#7
Hui Juan Chen, Jiqiu Wen, Rongfeng Qi, Jianhui Zhong, U Joseph Schoepf, Akos Varga-Szemes, Virginia W Lesslie, Xiang Kong, Yun Fei Wang, Qiang Xu, Zhe Zhang, Xue Li, Guang Ming Lu, Long Jiang Zhang
BACKGROUND AND OBJECTIVES: Cognition in ESRD may be improved by kidney transplantation, but mechanisms are unclear. We explored patterns of resting-state networks with resting-state functional magnetic resonance imaging among patients with ESRD before and after kidney transplantation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Thirty-seven patients with ESRD scheduled for kidney transplantation and 22 age-, sex-, and education-matched healthy subjects underwent resting-state functional magnetic resonance imaging...
October 18, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29046028/-aria-2016-executive-summary-integrated-care-pathways-for-predictive-medicine-throughout-the-life-cycle-in-argentina
#8
Juan Carlos Ivancevich, Hugo Neffen, Mario E Zernotti, Estrella Asayag, Ariel Blua, Alberto Cicerán, Edgardo J Jares, Alberto J Lavrut, Jorge F Máspero, Ioana Agache, Claus Bachert, Anna Bedbrook, Giorgio W Canonica, Thomas B Casale, Álvaro A Cruz, Wytske J Fokkens, Peter W Hellings, Boleslaw Samolinski, Jean Bousquet
The ARIA initiative was started during a World Health Organization workshop in 1999. The initial goals were to propose a new classification for allergic rhinitis, to promote the concept of multi-morbidity in asthma and rhinitis and to develop guidelines with stakeholders for world-wide use. ARIA is now focused on the implementation of emerging technologies for individualized and predictive medicine. MASK: MACVIA-Aria Sentinel Network uses mobile technology to develop care pathways that enable management by a multidisciplinary group or by patients themselves...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045329/hybrid-deep-learning-on-single-wide-field-optical-coherence-tomography-scans-accurately-classifies-glaucoma-suspects
#9
Hassan Muhammad, Thomas J Fuchs, Nicole De Cuir, Carlos G De Moraes, Dana M Blumberg, Jeffrey M Liebmann, Robert Ritch, Donald C Hood
PURPOSE: Existing summary statistics based upon optical coherence tomographic (OCT) scans and/or visual fields (VFs) are suboptimal for distinguishing between healthy and glaucomatous eyes in the clinic. This study evaluates the extent to which a hybrid deep learning method (HDLM), combined with a single wide-field OCT protocol, can distinguish eyes previously classified as either healthy suspects or mild glaucoma. METHODS: In total, 102 eyes from 102 patients, with or suspected open-angle glaucoma, had previously been classified by 2 glaucoma experts as either glaucomatous (57 eyes) or healthy/suspects (45 eyes)...
October 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29045321/fundus-wide-subretinal-and-pigment-epithelial-abnormalities-in-macular-telangiectasia-type-2
#10
Michael B Powner, Sasha M Woods, Meidong Zhu, Mark C Gillies, Paul S Bernstein, Gregory S Hageman, Grant M Comer, Catherine Egan, Marcus Fruttiger
PURPOSE: Macular telangiectasia Type 2 (MacTel) causes glial and photoreceptor cell death in a small, oval patch in the central retina. Beyond this oval area, no disease manifestations have been described so far. Here, we describe a novel pathological aspect of MacTel in the retinal pigment epithelium (RPE) that is not restricted to the clinically affected area but covers the entire retina. METHODS: We have studied postmortem eyes from four patients with MacTel by immunohistochemistry and electron microscopy...
October 17, 2017: Retina
https://www.readbyqxmd.com/read/29044711/the-surgical-anatomy-of-the-sural-nerve-an-ultrasound-study
#11
Patrick Popieluszko, Ewa Mizia, Brandon Michael Henry, Przemysław A Pękala, Beatrice Sanna, Joyeeta Roy, Marios Loukas, Krzysztof A Tomaszewski
PURPOSE: The aim of this study was (a) to examine the anatomy of the sural nerve (SN) in a sample of ______ patients and (b) to analyze the incidence of different origins of the SN, and the distance of the SN from planned arthroscopic portals. METHODS: An ultrasound (USG) examination of the SN was performed bilaterally on thirty healthy patients with no history of surgery or trauma of the lower limb. The SNs were classified into six main types of pattern, with an additional category for new and unclassified types...
October 17, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/29044248/task-demands-tdcs-intensity-and-the-comt-val-158-met-polymorphism-impact-tdcs-linked-working-memory-training-gains
#12
Jaclyn A Stephens, Kevin T Jones, Marian E Berryhill
Working memory (WM) training paired with transcranial direct current stimulation (tDCS) can improve executive function in older adults. The unclear mechanism of tDCS likely depends on tDCS intensity, and task relevant genetic factors (e.g., for WM: COMT val(158)met, DAT, BDNF val(66)met). Higher tDCS intensity does not always lead to greater cognitive gains, and genetic polymorphisms may modulate tDCS-linked WM improvements. To evaluate these factors, 137 healthy older adults provided DNA samples and received Visual and Spatial WM training paired with tDCS (sham, 1, 1...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043761/exploring-sales-data-during-a-healthy-corner-store-intervention-in-toronto-the-food-retail-environments-shaping-health-fresh-project
#13
Leia M Minaker, Meghan Lynch, Brian E Cook, Catherine L Mah
INTRODUCTION: Population health interventions in the retail food environment, such as corner store interventions, aim to influence the kind of cues consumers receive so that they are more often directed toward healthier options. Research that addresses financial aspects of retail interventions, particularly using outcome measures such as store sales that are central to retail decision making, is limited. This study explored store sales over time and across product categories during a healthy corner store intervention in a lowincome neighbourhood in Toronto, Ontario...
October 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29042814/attenuated-serum-adiponectin-levels-are-associated-with-disease-severity-in-patients-with-non-traumatic-osteonecrosis-of-the-femoral-head
#14
Yong-Bin Yue, Xin Liu, Biao-Fang Wei
OBJECTIVE: Decreased adiponectin (APN) levels have been detected in patients with osteonecrosis of the femoral head (ONFH). The scope of this study was aimed to explore the relationship between serum APN levels and disease severity in nontraumatic ONFH patients. PATIENTS AND METHODS: Ninety two nontraumatic ONFH patients and 92 healthy controls were enrolled for this study following the estimation of sample size. Serum APN concentrations were examined by enzyme-linked immunosorbent assay (ELISA)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29042805/efficacy-of-the-combined-use-of-a-mild-foaming-cleanser-and-moisturizer-for-the-care-of-infant-skin
#15
Naoko Okamoto, Kaori Umehara, Junko Sonoda, Mitsuyuki Hotta, Hiroki Mizushima, Yutaka Takagi, Keiko Matsuo, Naoko Baba
OBJECTIVE: Despite the application of skin care treatments, many infants have skin problems such as dryness and erythema. We proposed a new combination skin care for infants which consisted of a foaming cleanser with lower surfactant activity and moisturizers that contained pseudo-ceramide. SUBJECTS AND METHODS: A total of 50 infants (age: 3-24 months) with insignificant levels of dry skin were enrolled in this usage trial. The parents washed the infants with the test cleanser while bathing and then applied the moisturizer (lotion or cream) containing pseudo-ceramide...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29042162/pronation-and-supination-analysis-based-on-biomechanical-signals-from-parkinson-s-disease-patients
#16
Alejandro Garza-Rodríguez, Luis Pastor Sánchez-Fernández, Luis Alejandro Sánchez-Pérez, Christopher Ornelas-Vences, Mariane Ehrenberg-Inzunza
In this work, a fuzzy inference model to evaluate hands pronation/supination exercises during the MDS-UPDRS motor examination is proposed to analyze different extracted features from the bio-mechanical signals acquired from patients with Parkinson's disease (PD) in different stages of severity. Expert examiners perform visual assessments to evaluate several aspects of the disease. Some previous work on this subject does not contemplate the MDS-UPDRS guidelines. The method proposed in this work quantifies the biomechanical features examiners evaluate...
October 14, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29041837/infective-keratitis-in-indian-patients-with-corneal-dystrophies
#17
Anita Ganger, Noopur Gupta, Ankit S Tomar, Murugesan Vanathi, Radhika Tandon
All eight patients seen with various types of corneal dystrophy, a rare hereditary corneal disease, presented with infective keratitis. Unilateral microbial invasion was seen in all patients and the visual acuity of the affected eyes was <6/60 at presentation. We highlight our impression that microbial invasion can occur with all types of epithelial and stromal corneal dystrophy, including macular corneal dystrophy. Regular follow-up to maintain a healthy ocular surface is recommended to avert blindness in such patients...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29040812/a-randomized-controlled-cross-over-study-of-appetite-related-sensations-after-consuming-snacks-made-from-buckwheat
#18
Danielle M Defries, Jay C Petkau, Terri Gregor, Heather Blewett
With the rising incidence of overweight and obesity in developed countries, there is an interest in developing food products that may aid in satiety and reduce energy intake. Buckwheat is a gluten-free edible seed that has been previously shown to induce changes in post-prandial concentrations of satiety hormones; however, subjective measures of appetite-related sensations and objective measures of energy intake at subsequent meals following buckwheat consumption have not been measured. Thirty eight healthy adults were recruited to participate in a randomized, controlled, cross-over trial with the main objective to determine if consuming snacks made from buckwheat would increase satiety and reduce energy intake compared to snacks comparable in serving size, physical characteristics, and nutrient composition...
October 17, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29038845/clinical-and-sonographic-evaluation-of-subpectoral-biceps-tenodesis-with-a-dual-suture-anchor-technique-demonstrates-improved-outcomes-and-a-low-failure-rate-at-a-minimum-2-year-follow-up
#19
Matthijs Jacxsens, Erin K Granger, Robert Z Tashjian
INTRODUCTION: The purpose of this study was to evaluate the clinical outcomes and integrity of an open subpectoral biceps tenodesis using a dual suture anchor construct. MATERIALS AND METHODS: Patients with at least 2 years of follow-up were retrospectively evaluated for simple shoulder test (SST), American Shoulder and Elbow Surgeons (ASES) score, and visual analog scales (VAS) for pain, function and satisfaction. A physical exam assessed shoulder range of motion and elbow strength...
October 16, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29038599/widespread-white-matter-microstructural-differences-in-schizophrenia-across-4322-individuals-results-from-the-enigma-schizophrenia-dti-working-group
#20
S Kelly, N Jahanshad, A Zalesky, P Kochunov, I Agartz, C Alloza, O A Andreassen, C Arango, N Banaj, S Bouix, C A Bousman, R M Brouwer, J Bruggemann, J Bustillo, W Cahn, V Calhoun, D Cannon, V Carr, S Catts, J Chen, J-X Chen, X Chen, C Chiapponi, Kl K Cho, V Ciullo, A S Corvin, B Crespo-Facorro, V Cropley, P De Rossi, C M Diaz-Caneja, E W Dickie, S Ehrlich, F-M Fan, J Faskowitz, H Fatouros-Bergman, L Flyckt, J M Ford, J-P Fouche, M Fukunaga, M Gill, D C Glahn, R Gollub, E D Goudzwaard, H Guo, R E Gur, R C Gur, T P Gurholt, R Hashimoto, S N Hatton, F A Henskens, D P Hibar, I B Hickie, L E Hong, J Horacek, F M Howells, H E Hulshoff Pol, C L Hyde, D Isaev, A Jablensky, P R Jansen, J Janssen, E G Jönsson, L A Jung, R S Kahn, Z Kikinis, K Liu, P Klauser, C Knöchel, M Kubicki, J Lagopoulos, C Langen, S Lawrie, R K Lenroot, K O Lim, C Lopez-Jaramillo, A Lyall, V Magnotta, R C W Mandl, D H Mathalon, R W McCarley, S McCarthy-Jones, C McDonald, S McEwen, A McIntosh, T Melicher, R I Mesholam-Gately, P T Michie, B Mowry, B A Mueller, D T Newell, P O'Donnell, V Oertel-Knöchel, L Oestreich, S A Paciga, C Pantelis, O Pasternak, G Pearlson, G R Pellicano, A Pereira, J Pineda Zapata, F Piras, S G Potkin, A Preda, P E Rasser, D R Roalf, R Roiz, A Roos, D Rotenberg, T D Satterthwaite, P Savadjiev, U Schall, R J Scott, M L Seal, L J Seidman, C Shannon Weickert, C D Whelan, M E Shenton, J S Kwon, G Spalletta, F Spaniel, E Sprooten, M Stäblein, D J Stein, S Sundram, Y Tan, S Tan, S Tang, H S Temmingh, L T Westlye, S Tønnesen, D Tordesillas-Gutierrez, N T Doan, J Vaidya, N E M van Haren, C D Vargas, D Vecchio, D Velakoulis, A Voineskos, J Q Voyvodic, Z Wang, P Wan, D Wei, T W Weickert, H Whalley, T White, T J Whitford, J D Wojcik, H Xiang, Z Xie, H Yamamori, F Yang, N Yao, G Zhang, J Zhao, T G M van Erp, J Turner, P M Thompson, G Donohoe
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies...
October 17, 2017: Molecular Psychiatry
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