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https://www.readbyqxmd.com/read/27926760/epidermal-nerve-fiber-quantification-in-patients-with-erythromelalgia
#1
William G Mantyh, P James B Dyck, Peter J Dyck, Janean K Engelstad, William J Litchy, Paola Sandroni, Mark D P Davis
Importance: Erythromelalgia is a clinical diagnosis based on intermittent warmth, erythema, and pain in the distal extremities. One problem facing physicians is how to objectively test for this disease. Given that other painful conditions of the distal extremities (ie, neuropathy related to human immunodeficiency virus, diabetes, or Fabry disease) can be evaluated with a skin biopsy to visualize pathologically decreased densities of the small nerve fibers that innervate the epidermis, one hypothesis is that erythromelalgia could similarly be associated with a loss of epidermal nerve fiber density (ENFD)...
December 7, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27923277/reaction-time-for-processing-visual-stimulus-in-a-computer-assisted-rehabilitation-environment
#2
Yerly Sanchez, David Pinzon, Bin Zheng
PURPOSE: To examine the reaction time when human subjects process information presented in the visual channel under both a direct vision and a virtual rehabilitation environment when walking was performed. METHOD: Visual stimulus included eight math problems displayed on the peripheral vision to seven healthy human subjects in a virtual rehabilitation training (computer-assisted rehabilitation environment (CAREN)) and a direct vision environment. Subjects were required to verbally report the results of these math calculations in a short period of time...
December 7, 2016: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/27922659/eye-movement-analysis-and-cognitive-assessment-the-use-of-comparative-visual-search-tasks-in-a-non-immersive-vr-application
#3
Pedro J Rosa, Pedro Gamito, Jorge Oliveira, Diogo Morais, Matthew Pavlovic, Olivia Smyth, Inês Maia, Tiago Gomes
BACKGROUND: An adequate behavioral response depends on attentional and mnesic processes. When these basic cognitive functions are impaired, the use of non-immersive Virtual Reality Applications (VRAs) can be a reliable technique for assessing the level of impairment. However, most non-immersive VRAs use indirect measures to make inferences about visual attention and mnesic processes (e.g., time to task completion, error rate). OBJECTIVES: To examine whether the eye movement analysis through eye tracking (ET) can be a reliable method to probe more effectively where and how attention is deployed and how it is linked with visual working memory during comparative visual search tasks (CVSTs) in non-immersive VRAs...
December 6, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27922211/transrectal-ultrasonography-of-equine-lumbosacral-nerves-pilot-study-in-28-healthy-warmblood-horses
#4
Pablo Espinosa, Philippe Benoit, Isabel Salazar, Jesús de la Fuente, Philippe Heiles
A noninvasive method for visualizing lumbosacral nerves would be helpful for horses with suspected lumbosacral plexopathy or injury. The aim of this prospective descriptive pilot study was to characterize the ultrasonographic appearance of the lumbosacral nerves in a sample of healthy horses, and expand on the technique for image acquisition. Horses were recruited for inclusion if they were determined to be healthy and sound based on clinical and lameness evaluation. Transrectal ultrasound images of the lumbosacral nerves (L6, S1, and S2) were obtained for both sides...
December 6, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27921216/neural-correlates-of-rumination-in-adolescents-with-remitted-major-depressive-disorder-and-healthy-controls
#5
Katie L Burkhouse, Rachel H Jacobs, Amy T Peters, Olu Ajilore, Edward R Watkins, Scott A Langenecker
The aim of the present study was to use fMRI to examine the neural correlates of engaging in rumination among a sample of remitted depressed adolescents, a population at high risk for future depressive relapse. A rumination induction task was used to assess differences in the patterns of neural activation during rumination versus a distraction condition among 26 adolescents in remission from major depressive disorder (rMDD) and in 15 healthy control adolescents. Self-report depression and rumination, as well as clinician-rated depression, were also assessed among all participants...
December 5, 2016: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/27920096/structural-pathways-supporting-swift-acquisition-of-new-visuomotor-skills
#6
Ari E Kahn, Marcelo G Mattar, Jean M Vettel, Nicholas F Wymbs, Scott T Grafton, Danielle S Bassett
Human skill learning requires fine-scale coordination of distributed networks of brain regions linked by white matter tracts to allow for effective information transmission. Yet how individual differences in these anatomical pathways may impact individual differences in learning remains far from understood. Here, we test the hypothesis that individual differences in structural organization of networks supporting task performance predict individual differences in the rate at which humans learn a visuomotor skill...
December 5, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27919482/the-association-of-cognitive-impairment-with-gray-matter-atrophy-and-cortical-lesion-load-in-clinically-isolated-syndrome
#7
Sevda Diker, Arzu Ceylan Has, Aslı Kurne, Rahşan Göçmen, Kader Karlı Oğuz, Rana Karabudak
BACKGROUND: Multiple sclerosis can impair cognition from the early stages and has been shown to be associated with gray matter damage in addition to white matter pathology. OBJECTIVES: To investigate the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline. METHODS: Thirty patients with clinically isolated syndrome and twenty demographically- matched healthy controls underwent neuropsychologic assessment through the Rao Brief Repeatable Battery, and brain magnetic resonance imaging with double inversion recovery using a 3T scanner...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27918970/-not-just-right-experiences-and-incompleteness-in-body-dysmorphic-disorder
#8
Berta J Summers, Natalie L Matheny, Jesse R Cougle
The current studies examined the role of 'not just right' experiences (NJREs) and incompleteness (INC) in body dysmorphic disorder (BDD). In Study 1, a clinical BDD sample endorsed more severe NJREs than healthy controls, when controlling co-occurring symptoms of depression and anxiety. In Study 2, INC predicted reactivity to an in vivo task designed to evoke BDD-related concerns in an unselected sample. Study 3 demonstrated a positive relationship between INC and BDD symptom severity in a community sample...
November 28, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27918827/optic-radiations-microstructural-changes-in-glaucoma-and-association-with-severity-a-study-using-3tesla-magnetic-resonance-diffusion-tensor-imaging
#9
Laury Tellouck, Muriel Durieux, Pierrick Coupé, Audrey Cougnard-Grégoire, Joy Tellouck, Thomas Tourdias, Fanny Munsch, Arnaud Garrigues, Catherine Helmer, Florence Malet, Jean-François Dartigues, Vincent Dousset, Cécile Delcourt, Cédric Schweitzer
Purpose: To compare microstructural changes along the optical radiations and brain structure volumes between glaucoma and control subjects using in vivo magnetic resonance imaging and to analyze their association with severity of the disease. Methods: A total of 50 open-angle glaucoma subjects and 50 healthy age- and sex-matched controls underwent detailed ophthalmologic examinations (including visual field testing [VF], funduscopy, and spectral-domain optical coherence tomography) as well as diffusion tensor imaging (DTI) using 3...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27918749/correlation-of-nasal-mucosal-temperature-with-subjective-nasal-patency-in-healthy-individuals
#10
Ryan S Bailey, Kevin P Casey, Sachin S Pawar, Guilherme J M Garcia
Importance: Historically, otolaryngologists have focused on nasal resistance to airflow and minimum airspace cross-sectional area as objective measures of nasal obstruction using methods such as rhinomanometry and acoustic rhinometry. However, subjective sensation of nasal patency may be more associated with activation of cold receptors by inspired air than with respiratory effort. Objective: To investigate whether subjective nasal patency correlates with nasal mucosal temperature in healthy individuals...
December 1, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27918231/a-3d-assessment-and-feedback-tool-for-ankylosing-spondylitis-from-the-perspective-of-healthcare-professionals
#11
Shijuan Li, Stephen Kay, Stuart Porter
To investigate the utility of 3D visualization technology to augment assessment and feedback for Ankylosing Spondylitis (AS), a visualization prototype was developed, and both subjective and objective measures of current assessment instruments were compared. To verify and establish a base-line for the prototype's effectiveness, motion data and measurement data from a healthy adult in a laboratory environment were collected. To validate the prototype, a qualitative evaluation was undertaken using multiple methods including a pilot study, focus groups, and individual interviews...
December 5, 2016: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/27917850/an-assessment-of-marital-adjustment-in-patients-with-rheumatoid-arthritis
#12
Hatice Resorlu, Basak Sahin, Hulya Ertekin, Serhad Bilim, Yılmaz Savas
Aim To investigate marital adjustment in patients with rheumatoid arthritis and factors affecting this. Methods A total of 32 patients diagnosed with Steinbrocker class 1-2 rheumatoid arthritis and 32 healthy individuals from a similar age group were included. Sociodemographic characteristics, the Beck Depression Inventory (BDI), short-form 36(SF-36) and the dyadic adjustment scale (DAS) were evaluated in both groups. A visual analogue scale (VAS), the disease activity score 28(DAS28) and a health assessment questionnaire (HAQ) were also investigated in the patient group...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/27917468/dry-skin-conditions-are-related-to-the-recovery-rate-of-skin-temperature-after-cold-stress-rather-than-to-blood-flow
#13
Yasuko Yoshida-Amano, Tomoko Nomura, Yoshinori Sugiyama, Kayoko Iwata, Yuko Higaki, Masanori Tanahashi
BACKGROUND: Cutaneous blood flow plays an important role in the thermoregulation, oxygen supply, and nutritional support necessary to maintain the skin. However, there is little evidence for a link between blood flow and skin physiology. Therefore, we conducted surveys of healthy volunteers to determine the relationship(s) between dry skin properties and cutaneous vascular function. METHODS: Water content of the stratum corneum, transepidermal water loss, and visual dryness score were investigated as dry skin parameters...
December 4, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27917112/reproducibility-and-reliability-of-quantitative-and-weighted-t1-and-t2-%C3%A2-mapping-for-myelin-based-cortical-parcellation-at-7-tesla
#14
Roy A M Haast, Dimo Ivanov, Elia Formisano, Kâmil Uludaǧ
Different magnetic resonance (MR) parameters, such as R1 (=1/T1) or T2(∗), have been used to visualize non-invasively the myelin distribution across the cortical sheet. Myelin contrast is consistently enhanced in the primary sensory and some higher order cortical areas (such as MT or the cingulate cortex), which renders it suitable for subject-specific anatomical cortical parcellation. However, no systematic comparison has been performed between the previously proposed MR parameters, i.e., the longitudinal and transversal relaxation values (or their ratios), for myelin mapping at 7 Tesla...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27917105/eeg-negativity-in-fixations-used-for-gaze-based-control-toward-converting-intentions-into-actions-with-an-eye-brain-computer-interface
#15
Sergei L Shishkin, Yuri O Nuzhdin, Evgeny P Svirin, Alexander G Trofimov, Anastasia A Fedorova, Bogdan L Kozyrskiy, Boris M Velichkovsky
We usually look at an object when we are going to manipulate it. Thus, eye tracking can be used to communicate intended actions. An effective human-machine interface, however, should be able to differentiate intentional and spontaneous eye movements. We report an electroencephalogram (EEG) marker that differentiates gaze fixations used for control from spontaneous fixations involved in visual exploration. Eight healthy participants played a game with their eye movements only. Their gaze-synchronized EEG data (fixation-related potentials, FRPs) were collected during game's control-on and control-off conditions...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27916665/task-modulations-and-clinical-manifestations-in-the-brain-functional-connectome-in-1615-fmri-datasets
#16
Tobias Kaufmann, Dag Alnæs, Christine Lycke Brandt, Nhat Trung Doan, Karolina Kauppi, Francesco Bettella, Trine V Lagerberg, Akiah O Berg, Srdjan Djurovic, Ingrid Agartz, Ingrid S Melle, Torill Ueland, Ole A Andreassen, Lars T Westlye
OBJECTIVE: An abundance of experimental studies have motivated a range of models concerning the cognitive underpinnings of severe mental disorders, yet the conception that cognitive and brain dysfunction is confined to specific cognitive domains and contexts has limited ecological validity. Schizophrenia and bipolar spectrum disorders have been conceptualized as disorders of brain connectivity; yet little is known about the pervasiveness across cognitive tasks. METHOD: To address this outstanding issue of context specificity, we estimated functional network connectivity from fMRI data obtained during five cognitive tasks (0-back, 2-back, go/no-go, recognition of positive faces, negative faces) in 90 patients with schizophrenia, 97 patients with bipolar spectrum disorder, and 136 healthy controls, including 1615 fMRI datasets in total...
December 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/27916386/beneficial-effect-of-bilingualism-on-alzheimer-s-disease-csf-biomarkers-and-cognition
#17
Ainara Estanga, Mirian Ecay-Torres, Almudena Ibañez, Andrea Izagirre, Jorge Villanua, Maite Garcia-Sebastian, M Teresa Iglesias Gaspar, Ane Otaegui-Arrazola, Ane Iriondo, Monserrat Clerigue, Pablo Martinez-Lage
Bilingualism as a component of cognitive reserve has been claimed to delay the onset of Alzheimer's disease (AD). However, its effect on cerebrospinal fluid (CSF) AD-biomarkers has not been investigated. We assessed cognitive performance and CSF AD-biomarkers, and potential moderation effect of bilingualism on the association between age, CSF AD-biomarkers, and cognition. Cognitively healthy middle-aged participants classified as monolinguals (n = 100, nCSF = 59), early (n = 81, nCSF = 55) and late bilinguals (n = 97, nCSF = 52) were evaluated...
December 1, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27915067/the-feasibility-and-effects-of-acupuncture-in-an-adolescent-nordic-ski-population
#18
Kristin L Garlanger, William H Fredericks, Alexander Do, Brent A Bauer, Edward R Laskowski
BACKGROUND: Studies investigating the use and effectiveness of acupuncture in adults post exercise have been well documented. Fewer studies involving acupuncture have been completed in the adolescent athlete population. To our knowledge there are no published studies that investigate the use of acupuncture in adolescent athletes within their field of play. OBJECTIVE: To primarily assess the feasibility of performing acupuncture in adolescent Nordic skiers within their athletic environment, and secondarily to measure the effect of acupuncture on muscle soreness and sense of well-being...
November 30, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27913943/the-cost-effectiveness-of-interventions-targeting-lifestyle-change-for-the-prevention-of-diabetes-in-a-swedish-primary-care-and-community-based-prevention-program
#19
Anne Neumann, Lars Lindholm, Margareta Norberg, Olaf Schoffer, Stefanie J Klug, Fredrik Norström
BACKGROUND: Policymakers need to know the cost-effectiveness of interventions to prevent type 2 diabetes (T2D). The objective of this study was to estimate the cost-effectiveness of a T2D prevention initiative targeting weight reduction, increased physical activity and healthier diet in persons in pre-diabetic states by comparing a hypothetical intervention versus no intervention in a Swedish setting. METHODS: A Markov model was used to study the cost-effectiveness of a T2D prevention program based on lifestyle change versus a control group where no prevention was applied...
December 2, 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/27913591/temporal-expectations-guide-dynamic-prioritization-in-visual-working-memory-through-attenuated-alpha-oscillations
#20
Freek van Ede, Marcel Niklaus, Anna C Nobre
: While working memory is generally considered a highly dynamic mnemonic store, popular laboratory tasks employed to understand its psychological and neural mechanisms (such as change detection and continuous reproduction) often remain relatively "static", involving the retention of a set number of items throughout a shared delay interval. In the current study, we investigated visual working memory in a more dynamic setting, and assessed: 1) whether internally guided temporal expectations can dynamically and reversibly prioritize individual mnemonic items at specific times at which they are deemed most relevant and 2) the neural substrates that support such dynamic prioritization...
December 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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