Yafei Jiang, Gangyang Wang, Haoran Mu, Xiaojun Ma, Zhuoying Wang, Yu Lv, Tao Zhang, Jing Xu, Jinzeng Wang, Yunqi Li, Jing Han, Mengkai Yang, Zongyi Wang, Ke Zeng, Xinmeng Jin, Song Xue, Mingzhu Yin, Wei Sun, Yingqi Hua, Zhengdong Cai
Osteosarcoma is the most common primary malignant bone tumor, and there are few ideal clinically available drugs. The bromodomain and extraterminal domain (BET) protein is an emerging target for aggressive cancer, but therapies targeting the BET in osteosarcoma have been unsuccessful in clinical trials to date, and further exploration of specific BET inhibitors is of great significance. In our study, we demonstrated that NHWD-870, a potent BET inhibitor in a phase I clinical trial, significantly inhibited tumor proliferation and promoted cell apoptosis by reversing the oncogenic signature in osteosarcoma...
2021: Frontiers in Oncology